Compounds > aica ribonucleotide

aica ribonucleotide and Carcinoma, Hepatocellular

aica ribonucleotide has been researched along with Carcinoma, Hepatocellular in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (7.14)18.2507
2000's5 (35.71)29.6817
2010's6 (42.86)24.3611
2020's2 (14.29)2.80

Authors

AuthorsStudies
Irokawa, H; Itoh, F; Kuge, S; Sasaki, M; Sekine, R; Shibata, N; Takeda, K; Tanaka, Y; Ueda, T; Yamamoto, K1
Ganapathy, V; Higuchi, K; Kopel, J; Ramachandran, S; Ristic, B; Sato, T1
Gao, J; Jiang, G; Xiong, D; Xiong, R; Yin, T; Yin, Z; Zhang, S; Zhang, X; Zhao, W1
Cai, B; Cai, X; Chen, X; Cheng, J; Hu, H; Hu, X; Huang, J; Jing, X; Li, Y; Tan, X; Wang, Q1
Chen, W; Cheng, J; Cheng, W; Guo, Y; Huang, J; Huang, T; Jing, X; Li, Y; Tan, X; Wang, Q; Yamamoto, T; Zhang, Y; Zhu, Y1
Gao, R; Goswami, R; Li, Q; Liu, L; Lv, Q; Yang, S; Zhen, Q; Zhou, H1
Ka, SO; Kim, JH; Kim, SJ; Park, BH; Park, JH; Shen, C1
Cooksey, RC; Landaker, E; McClain, D; Park, J; Patti, ME; Ruddock, MW; Stein, A1
Banerjee, S; Ghoshal, S; Porter, TD1
Araki, E; Igata, M; Kawashima, J; Kondo, T; Matsumoto, K; Miyamura, N; Motoshima, H; Murata, Y; Nakamaru, K; Suefuji, M; Taguchi, T; Toyonaga, T; Tsuruzoe, K1
Zhuge, J1
Doiron, B; Kahn, A; Leclerc, I1
Lewitt, MS1
Esumi, H; Imamura, K; Kaminishi, M; Kishimoto, A; Ogura, T1

Other Studies

14 other study(ies) available for aica ribonucleotide and Carcinoma, Hepatocellular

ArticleYear
One-carbon metabolizing enzyme ALDH1L1 influences mitochondrial metabolism through 5-aminoimidazole-4-carboxamide ribonucleotide accumulation and serine depletion, contributing to tumor suppression.
    Scientific reports, 2023, 08-18, Volume: 13, Issue:1

    Topics: Carbon; Carcinoma, Hepatocellular; Humans; Liver Neoplasms; Ribonucleotides

2023
The Hepatic Plasma Membrane Citrate Transporter NaCT (SLC13A5) as a Molecular Target for Metformin.
    Scientific reports, 2020, 05-22, Volume: 10, Issue:1

    Topics: Aminoimidazole Carboxamide; Carcinoma, Hepatocellular; Citric Acid; Gene Expression Regulation, Neoplastic; Glycolysis; Hep G2 Cells; Humans; Hypoglycemic Agents; Liver Neoplasms; Metformin; Molecular Targeted Therapy; Ribonucleotides; Signal Transduction; Symporters; TOR Serine-Threonine Kinases

2020
The Adenosine Monophosphate (AMP) Analog, 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Inhibits Hepatosteatosis and Liver Tumorigenesis in a High-Fat Diet Murine Model Treated with Diethylnitrosamine (DEN).
    Medical science monitor : international medical journal of experimental and clinical research, 2018, Nov-26, Volume: 24

    Topics: Adenosine Monophosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Diet, High-Fat; Diethylnitrosamine; Disease Models, Animal; Fatty Liver; Interleukin-6; Lipid Metabolism; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Ribonucleotides; STAT3 Transcription Factor; Triglycerides

2018
Metformin suppresses hepatocellular carcinoma cell growth through induction of cell cycle G1/G0 phase arrest and p21CIP and p27KIP expression and downregulation of cyclin D1 in vitro and in vivo.
    Oncology reports, 2013, Volume: 30, Issue:5

    Topics: Aminoimidazole Carboxamide; Animals; Carcinoma, Hepatocellular; Cell Survival; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Metformin; Mice; Ribonucleotides; Xenograft Model Antitumor Assays

2013
AMP-activated protein kinase suppresses the in vitro and in vivo proliferation of hepatocellular carcinoma.
    PloS one, 2014, Volume: 9, Issue:4

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Carcinoma, Hepatocellular; Cell Proliferation; Hep G2 Cells; Heterografts; Humans; Hypoglycemic Agents; Ki-67 Antigen; Liver Neoplasms; Metformin; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Proteins; Neoplasm Transplantation; Neovascularization, Pathologic; Ribonucleotides

2014
AMP-kinase pathway is involved in tumor necrosis factor alpha-induced lipid accumulation in human hepatoma cells.
    Life sciences, 2015, Jun-15, Volume: 131

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Carcinoma, Hepatocellular; Hep G2 Cells; Humans; Lipid Metabolism; Liver Neoplasms; Metformin; Phosphorylation; Ribonucleotides; Sterol Regulatory Element Binding Protein 1; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha

2015
Metformin and AICAR regulate NANOG expression via the JNK pathway in HepG2 cells independently of AMPK.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016, Volume: 37, Issue:8

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antineoplastic Agents; Blotting, Western; Carcinoma, Hepatocellular; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Hep G2 Cells; Humans; Hypoglycemic Agents; Liver Neoplasms; MAP Kinase Signaling System; Metformin; Nanog Homeobox Protein; Real-Time Polymerase Chain Reaction; Ribonucleotides

2016
Saturated fatty acids inhibit hepatic insulin action by modulating insulin receptor expression and post-receptor signalling.
    Journal of biochemistry, 2008, Volume: 144, Issue:5

    Topics: Aminoimidazole Carboxamide; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Enzyme Activation; Enzyme Inhibitors; Epoxy Compounds; Extracellular Signal-Regulated MAP Kinases; Fatty Acids; Fatty Acids, Nonesterified; Forkhead Transcription Factors; Glycogen Synthase Kinase 3; Hypoglycemic Agents; Insulin; Insulin Receptor Substrate Proteins; Liver; Liver Neoplasms; Mice; Mice, Knockout; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Palmitic Acid; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Receptor, Insulin; Ribonucleotides; Signal Transduction; Triazenes

2008
Activation of AMP-kinase by policosanol requires peroxisomal metabolism.
    Lipids, 2011, Volume: 46, Issue:4

    Topics: Adenylate Kinase; Aldehyde Oxidoreductases; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Anticholesteremic Agents; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Carcinoma, Hepatocellular; Cells, Cultured; Enzyme Activation; Fatty Alcohols; Female; Humans; Hydroxymethylglutaryl CoA Reductases; Hypoglycemic Agents; Liver; Metformin; Mice; Mice, Inbred C57BL; Peroxisomes; Protein Serine-Threonine Kinases; Rats; Ribonucleotides

2011
AICAR, an activator of AMP-activated protein kinase, down-regulates the insulin receptor expression in HepG2 cells.
    Biochemical and biophysical research communications, 2005, Mar-11, Volume: 328, Issue:2

    Topics: 3T3-L1 Cells; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Mice; Multienzyme Complexes; Protein Serine-Threonine Kinases; Receptor, Insulin; Ribonucleotides

2005
Overexpression of CYP2E1 induces HepG2 cells death by the AMP kinase activator 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR).
    Cell biology and toxicology, 2009, Volume: 25, Issue:3

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytochrome P-450 CYP2E1; DNA, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Hepatocytes; Humans; L-Lactate Dehydrogenase; Necrosis; Rats; Reactive Oxygen Species; Ribonucleotides; Transfection; Tubercidin

2009
The 5'-AMP-activated protein kinase inhibits the transcriptional stimulation by glucose in liver cells, acting through the glucose response complex.
    FEBS letters, 1998, Jul-17, Volume: 431, Issue:2

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Carcinoma, Hepatocellular; Cells, Cultured; Enzyme Activation; Fatty Acid Synthases; Glucose; Glucose-6-Phosphate; Liver; Mice; Mice, Transgenic; Multienzyme Complexes; Nuclear Proteins; Phosphorylation; Promoter Regions, Genetic; Protein Kinases; Protein Serine-Threonine Kinases; Proteins; Pyruvate Kinase; Ribonucleotides; RNA, Messenger; Transcription Factors; Transcriptional Activation; Transfection; Tumor Cells, Cultured

1998
Stimulation of IGF-binding protein-1 secretion by AMP-activated protein kinase.
    Biochemical and biophysical research communications, 2001, Apr-20, Volume: 282, Issue:5

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Arsenic Trioxide; Arsenicals; Carcinoma, Hepatocellular; Culture Media, Conditioned; Dexamethasone; Dose-Response Relationship, Drug; Drug Antagonism; Glucocorticoids; Insulin; Insulin Antagonists; Insulin-Like Growth Factor Binding Protein 1; Multienzyme Complexes; Oxides; Protein Serine-Threonine Kinases; Rats; Ribonucleotides; Signal Transduction; Tumor Cells, Cultured

2001
Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line.
    Biochemical and biophysical research communications, 2001, Sep-21, Volume: 287, Issue:2

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Carcinoma, Hepatocellular; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Activation; G1 Phase; Humans; Hypoglycemic Agents; Multienzyme Complexes; Phosphorylation; Protein Serine-Threonine Kinases; Ribonucleotides; S Phase; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2001