ah-21-132 has been researched along with Pulmonary-Eosinophilia* in 1 studies
1 other study(ies) available for ah-21-132 and Pulmonary-Eosinophilia
| Article | Year |
|---|---|
Human recombinant lymphokines and cytokines induce pulmonary eosinophilia in the guinea pig which is inhibited by ketotifen and AH 21-132.
Subcutaneous or intraperitoneal injection of recombinant human granulocyte-macrophage colony-stimulating factor, interleukin 3, or mouse tumour necrosis factor alpha, but not recombinant human interferon gamma, platelet-derived growth factor, or transforming growth factor beta caused selective eosinophilia of the pulmonary airways in the guinea pig. Unlike responses to platelet-activating factor, there was no attendant detectable airway hyperreactivity, but in common with responses to platelet-activating factor, eosinophilia of the airways was prevented by pretreatment with ketotifen or AH21-132. Cytokines or lymphokines may contribute to pulmonary eosinophilia in diseases such as asthma. Topics: Airway Resistance; Animals; Bronchoalveolar Lavage Fluid; Cytokines; Guinea Pigs; Ketotifen; Leukocyte Count; Lymphokines; Male; Naphthyridines; Pulmonary Eosinophilia; Recombinant Proteins; Respiratory Function Tests | 1990 |