agn-193836 has been researched along with Breast-Neoplasms* in 1 studies
1 other study(ies) available for agn-193836 and Breast-Neoplasms
Article | Year |
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Synthesis and biological activity of retinoic acid receptor-alpha specific amides.
Retinoids are analogues of all-trans-retinoic acid, a powerful hormone that mediates many fundamental biological processes. Cancer and other serious hyperproliferative diseases are attractive therapeutic targets for retinoids, but the therapeutic use of retinoids is limited due to severe toxicity. We report here the design of retinoid receptor-alpha specific ligands with growth inhibitory activity in breast cancer cell lines, and which do not cause the cutaneous toxicity associated with the currently available nonselective retinoid agonists. Topics: Amides; Antineoplastic Agents; Breast Neoplasms; Female; Humans; Hydrogen Bonding; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Retinoids; Structure-Activity Relationship | 2002 |