agn-193836 and Breast-Neoplasms

agn-193836 has been researched along with Breast-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for agn-193836 and Breast-Neoplasms

ArticleYear
Synthesis and biological activity of retinoic acid receptor-alpha specific amides.
    Bioorganic & medicinal chemistry letters, 2002, Nov-04, Volume: 12, Issue:21

    Retinoids are analogues of all-trans-retinoic acid, a powerful hormone that mediates many fundamental biological processes. Cancer and other serious hyperproliferative diseases are attractive therapeutic targets for retinoids, but the therapeutic use of retinoids is limited due to severe toxicity. We report here the design of retinoid receptor-alpha specific ligands with growth inhibitory activity in breast cancer cell lines, and which do not cause the cutaneous toxicity associated with the currently available nonselective retinoid agonists.

    Topics: Amides; Antineoplastic Agents; Breast Neoplasms; Female; Humans; Hydrogen Bonding; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Retinoids; Structure-Activity Relationship

2002