agmatine has been researched along with Seizures in 12 studies
Agmatine: Decarboxylated arginine, isolated from several plant and animal sources, e.g., pollen, ergot, herring sperm, octopus muscle.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Similar to lithium, agmatine plays a protective role in the central nervous system against seizures and has been reported to enhance the effect of different antiepileptic agents." | 7.76 | Agmatine enhances the anticonvulsant effect of lithium chloride on pentylenetetrazole-induced seizures in mice: Involvement of L-arginine/nitric oxide pathway. ( Bahremand, A; Dehpour, AR; Ghasemi, A; Ghasemi, M; Hedayat, T; Khodadad, TK; Payandemehr, B; Rahimian, R; Ziai, P, 2010) |
| "Agmatine pre-treatment significantly reduced the seizure grade and increased the onset time." | 5.33 | Agmatine reduces extracellular glutamate during pentylenetetrazole-induced seizures in rat brain: a potential mechanism for the anticonvulsive effects. ( Feng, Y; LeBlanc, MH; Regunathan, S, 2005) |
| "In PTZ-induced convulsions, the highest dose of agmatine (100 mg/kg) increased the seizure onset time and decreased percent survival." | 5.32 | Effect of agmatine on electrically and chemically induced seizures in mice. ( Aricioglu, F; Berkman, K; Kan, B; Korcegez, E; Yillar, O, 2003) |
| " Similar to lithium, agmatine also plays a protective role in the CNS against seizures and has been reported to enhance the effect of different antiepileptic agents." | 3.77 | Additive anticonvulsant effects of agmatine and lithium chloride on pentylenetetrazole-induced clonic seizure in mice: involvement of α₂-adrenoceptor. ( Amouzegar, A; Bahremand, A; Dehpour, AR; Ebrahimi, A; Ghasemi, A; Ghasemi, M; Khezrian, M; Meibodi, MA; Montaser-Kouhsari, L; Payandemehr, B; Rahimian, R; Ziai, P, 2011) |
| " This study investigated the effect of the interaction of melatonin and agmatine on seizure susceptibility in the mouse model of pentylenetetrazole (PTZ)-induced clonic seizures." | 3.77 | The interaction of melatonin and agmatine on pentylenetetrazole-induced seizure threshold in mice. ( Dehpour, AR; Hojati, A; Moezi, L; Shafaroodi, H, 2011) |
| " Similar to lithium, agmatine plays a protective role in the central nervous system against seizures and has been reported to enhance the effect of different antiepileptic agents." | 3.76 | Agmatine enhances the anticonvulsant effect of lithium chloride on pentylenetetrazole-induced seizures in mice: Involvement of L-arginine/nitric oxide pathway. ( Bahremand, A; Dehpour, AR; Ghasemi, A; Ghasemi, M; Hedayat, T; Khodadad, TK; Payandemehr, B; Rahimian, R; Ziai, P, 2010) |
| " The thresholds for the clonic seizures induced by the intravenous administration of gamma-aminobutyric acid (GABA)-antagonist, pentylenetetrazole (PTZ) were assessed in mice." | 3.73 | The synergistic anticonvulsant effect of agmatine and morphine: possible role of alpha 2-adrenoceptors. ( Dehpour, AR; Ebrahimkhani, MR; Ghaffari, K; Homayoun, H; Honar, H; Jannati, A; Kiani, S; Noorian, AR; Rashidi, N; Riazi, K, 2005) |
| "Agmatine also potentiates the anti-seizure activity of morphine." | 1.39 | Role of nitric oxide in additive anticonvulsant effects of agmatine and morphine. ( Bahremand, A; Dehpour, AR; Derakhshanian, H; Ebrahimi, A; Fadakar, K; Moghaddas, P; Payandemehr, B; Rahimian, R; Saadat, S, 2013) |
| "Agmatine pre-treatment significantly reduced the seizure grade and increased the onset time." | 1.33 | Agmatine reduces extracellular glutamate during pentylenetetrazole-induced seizures in rat brain: a potential mechanism for the anticonvulsive effects. ( Feng, Y; LeBlanc, MH; Regunathan, S, 2005) |
| "MES convulsion and glutamate convulsion were respectively induced by an electrical stimulation (110 V, 0." | 1.32 | Anticonvulsive effect of agmatine in mice. ( Li, J; Liu, Y; Lu, XQ; Su, RB; Wei, XL; Zheng, JQ, 2004) |
| "In PTZ-induced convulsions, the highest dose of agmatine (100 mg/kg) increased the seizure onset time and decreased percent survival." | 1.32 | Effect of agmatine on electrically and chemically induced seizures in mice. ( Aricioglu, F; Berkman, K; Kan, B; Korcegez, E; Yillar, O, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (50.00) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bahremand, T | 1 |
| Payandemehr, P | 1 |
| Riazi, K | 3 |
| Noorian, AR | 2 |
| Payandemehr, B | 4 |
| Sharifzadeh, M | 1 |
| Dehpour, AR | 7 |
| Rahimian, R | 3 |
| Bahremand, A | 3 |
| Ebrahimi, A | 2 |
| Saadat, S | 1 |
| Moghaddas, P | 1 |
| Fadakar, K | 1 |
| Derakhshanian, H | 1 |
| Kim, JW | 1 |
| Seung, H | 1 |
| Kim, KC | 1 |
| Gonzales, ELT | 1 |
| Oh, HA | 1 |
| Yang, SM | 1 |
| Ko, MJ | 1 |
| Han, SH | 1 |
| Banerjee, S | 1 |
| Shin, CY | 1 |
| Ziai, P | 2 |
| Khodadad, TK | 1 |
| Ghasemi, A | 2 |
| Ghasemi, M | 2 |
| Hedayat, T | 1 |
| Amouzegar, A | 1 |
| Khezrian, M | 1 |
| Montaser-Kouhsari, L | 1 |
| Meibodi, MA | 1 |
| Moezi, L | 1 |
| Shafaroodi, H | 1 |
| Hojati, A | 1 |
| Demehri, S | 1 |
| Homayoun, H | 2 |
| Honar, H | 2 |
| Vafaie, K | 1 |
| Roushanzamir, F | 1 |
| Su, RB | 1 |
| Wei, XL | 1 |
| Zheng, JQ | 1 |
| Liu, Y | 1 |
| Lu, XQ | 1 |
| Li, J | 1 |
| Aricioglu, F | 1 |
| Kan, B | 1 |
| Yillar, O | 1 |
| Korcegez, E | 1 |
| Berkman, K | 1 |
| Rashidi, N | 1 |
| Kiani, S | 1 |
| Ebrahimkhani, MR | 1 |
| Ghaffari, K | 1 |
| Jannati, A | 1 |
| Feng, Y | 1 |
| LeBlanc, MH | 1 |
| Regunathan, S | 1 |
| Luszczki, JJ | 1 |
| Czernecki, R | 1 |
| Wojtal, K | 1 |
| Borowicz, KK | 1 |
| Czuczwar, SJ | 1 |
12 other studies available for agmatine and Seizures
| Article | Year |
|---|---|
Modulation of the anticonvulsant effect of swim stress by agmatine.
Topics: Agmatine; Analgesics, Opioid; Animals; Anticonvulsants; Arginine; Disease Models, Animal; Dose-Respo | 2018 |
Role of nitric oxide in additive anticonvulsant effects of agmatine and morphine.
Topics: Agmatine; Animals; Anticonvulsants; Arginine; Convulsants; Dose-Response Relationship, Drug; Enzyme | 2013 |
Agmatine rescues autistic behaviors in the valproic acid-induced animal model of autism.
Topics: Agmatine; Animals; Autism Spectrum Disorder; Disease Models, Animal; Grooming; Hippocampus; Hyperkin | 2017 |
Agmatine enhances the anticonvulsant effect of lithium chloride on pentylenetetrazole-induced seizures in mice: Involvement of L-arginine/nitric oxide pathway.
Topics: Agmatine; Analysis of Variance; Animals; Antidepressive Agents; Arginine; Disease Models, Animal; Do | 2010 |
Additive anticonvulsant effects of agmatine and lithium chloride on pentylenetetrazole-induced clonic seizure in mice: involvement of α₂-adrenoceptor.
Topics: Agmatine; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Synergism; Lithium Chlori | 2011 |
The interaction of melatonin and agmatine on pentylenetetrazole-induced seizure threshold in mice.
Topics: Agmatine; Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Rela | 2011 |
Agmatine exerts anticonvulsant effect in mice: modulation by alpha 2-adrenoceptors and nitric oxide.
Topics: Adrenergic alpha-2 Receptor Antagonists; Agmatine; Animals; Anticonvulsants; Dose-Response Relations | 2003 |
Anticonvulsive effect of agmatine in mice.
Topics: Agmatine; Animals; Anticonvulsants; Dizocilpine Maleate; Electroshock; Excitatory Amino Acid Antagon | 2004 |
Effect of agmatine on electrically and chemically induced seizures in mice.
Topics: Agmatine; Animals; Convulsants; Dose-Response Relationship, Drug; Electroshock; Female; Male; Mice; | 2003 |
The synergistic anticonvulsant effect of agmatine and morphine: possible role of alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Agmatine; Analysis of Variance; Animals; Anticonvulsants; Dose-Respons | 2005 |
Agmatine reduces extracellular glutamate during pentylenetetrazole-induced seizures in rat brain: a potential mechanism for the anticonvulsive effects.
Topics: Agmatine; Animals; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Drug Interac | 2005 |
Agmatine enhances the anticonvulsant action of phenobarbital and valproate in the mouse maximal electroshock seizure model.
Topics: Agmatine; Animals; Anticonvulsants; Avoidance Learning; Drug Interactions; Drug Synergism; Electrosh | 2008 |