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agmatine and Morphine Abuse

agmatine has been researched along with Morphine Abuse in 17 studies

Agmatine: Decarboxylated arginine, isolated from several plant and animal sources, e.g., pollen, ergot, herring sperm, octopus muscle.

Research Excerpts

ExcerptRelevanceReference
"Agmatine is an imidazoline I(1) receptor endogenous ligand as well as its agonist, but more and more evidences suggest it has no influence on blood pressure."5.35Comparison of agmatine with moxonidine and rilmenidine in morphine dependence in vitro: role of imidazoline I(1) receptors. ( Li, F; Li, J; Liu, Y; Lu, XQ; Su, RB; Wu, N, 2009)
"Agmatine is an endogenous amine derived from arginine that potentiates morphine analgesia and blocks symptoms of naloxone-precipitated morphine withdrawal in rats."5.32Effect of agmatine on the development of morphine dependence in rats: potential role of cAMP system. ( Aricioglu, F; Means, A; Regunathan, S, 2004)
" In the present study, we investigated the role of agmatine in hippocampal neural progenitors in morphine dependence rats."3.88Agmatine inhibits chronic morphine exposure-induced impairment of hippocampal neural progenitor proliferation in adult rats. ( Chen, WQ; Li, J; Li, YF; Liu, Y; Lu, GY; Wu, N, 2018)
" In the present study, the effect of agmatine on the neuroadaptation of glutamate neurotransmission induced by morphine dependence, including changes of the extracellular glutamate level and glutamate receptors in the nucleus accumbens was investigated."3.77Agmatine modulates neuroadaptations of glutamate transmission in the nucleus accumbens of repeated morphine-treated rats. ( Li, J; Liu, Y; Lu, XQ; Su, RB; Wang, XF; Wu, N, 2011)
"Agmatine, an endogenous nitric oxide (NO) synthase inhibitor and ligand for imidazoline receptors, has been previously shown to prevent morphine dependence in rats."3.74Effect of agmatine on brain L-citrulline production during morphine withdrawal in rats: a microdialysis study in nucleus accumbens. ( Aricioğlu, F; Berkman, K; Gören, MZ; Yananli, H, 2007)
"Agmatine is an amine that is formed by decarboxylation of L-arginine by the enzyme arginine decarboxylase (ADC) and hydrolyzed by the enzyme agmatinase to putrescine."2.43Agmatine: biological role and therapeutic potentials in morphine analgesia and dependence. ( Regunathan, S, 2006)
"Agmatine itself was a weak analgesic which enhanced analgesic action of morphine and inhibited tolerance to and dependence on opioid."2.42A biphasic opioid function modulator: agmatine. ( Li, J; Qin, BY; Su, RB, 2003)
"Agmatine is an imidazoline I(1) receptor endogenous ligand as well as its agonist, but more and more evidences suggest it has no influence on blood pressure."1.35Comparison of agmatine with moxonidine and rilmenidine in morphine dependence in vitro: role of imidazoline I(1) receptors. ( Li, F; Li, J; Liu, Y; Lu, XQ; Su, RB; Wu, N, 2009)
" Both acute and chronic administration of agmatine reduced withdrawal signs in wild type mice and reduced only peripheral signs of morphine dependence in neuronal nitric oxide synthase knockout mice."1.32Agmatine reduces only peripheral-related behavioral signs, not the central signs, of morphine withdrawal in nNOS deficient transgenic mice. ( Aricioglu, F; Paul, IA; Regunathan, S, 2004)
"Agmatine is an endogenous amine derived from arginine that potentiates morphine analgesia and blocks symptoms of naloxone-precipitated morphine withdrawal in rats."1.32Effect of agmatine on the development of morphine dependence in rats: potential role of cAMP system. ( Aricioglu, F; Means, A; Regunathan, S, 2004)
"Agmatine is an endogenous amine derived from the decarboxylation of arginine by arginine decarboxylase (ADC), and metabolized to putrescine by agmatinase."1.31Effect of chronic morphine treatment on the biosynthesis of agmatine in rat brain and other tissues. ( Aricioglu-Kartal, F; Regunathan, S, 2002)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (23.53)18.2507
2000's10 (58.82)29.6817
2010's3 (17.65)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Liu, Y5
Lu, GY1
Chen, WQ1
Li, YF1
Wu, N5
Li, J10
Li, F2
Su, RB5
Lu, XQ3
Wang, XF1
Su, R1
Chen, Y1
Lu, X1
Aricioglu-Kartal, F2
Regunathan, S4
Qin, BY5
Aricioglu, F4
Paul, IA1
Ercil, E1
Dulger, G1
Means, A1
Yananli, H1
Gören, MZ1
Berkman, K1
Huang, Y1
Gong, ZH1
Wei, XL1
Uzbay, IT1
Li, X4
Pei, G3

Reviews

2 reviews available for agmatine and Morphine Abuse

ArticleYear
A biphasic opioid function modulator: agmatine.
    Acta pharmacologica Sinica, 2003, Volume: 24, Issue:7

    Topics: Agmatine; Analgesia; Analgesics, Opioid; Animals; Drug Interactions; Drug Tolerance; Morphine; Morph

2003
Agmatine: biological role and therapeutic potentials in morphine analgesia and dependence.
    The AAPS journal, 2006, Jul-21, Volume: 8, Issue:3

    Topics: Agmatine; Analgesia; Analgesics, Opioid; Animals; Drug Tolerance; Morphine; Morphine Dependence; Pai

2006

Other Studies

15 other studies available for agmatine and Morphine Abuse

ArticleYear
Agmatine inhibits chronic morphine exposure-induced impairment of hippocampal neural progenitor proliferation in adult rats.
    European journal of pharmacology, 2018, Jan-05, Volume: 818

    Topics: Agmatine; Animals; Brain-Derived Neurotrophic Factor; Cell Proliferation; Cyclic AMP; Cyclic AMP Res

2018
Comparison of agmatine with moxonidine and rilmenidine in morphine dependence in vitro: role of imidazoline I(1) receptors.
    European journal of pharmacology, 2009, Jun-10, Volume: 612, Issue:1-3

    Topics: Agmatine; Animals; Antihypertensive Agents; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Dose-Resp

2009
Agmatine modulates neuroadaptations of glutamate transmission in the nucleus accumbens of repeated morphine-treated rats.
    European journal of pharmacology, 2011, Jan-10, Volume: 650, Issue:1

    Topics: Adaptation, Physiological; Agmatine; Animals; Biological Transport; Extracellular Space; Gene Expres

2011
Imidazoline receptor antisera-selected/Nischarin regulates the effect of agmatine on the development of morphine dependence.
    Addiction biology, 2012, Volume: 17, Issue:2

    Topics: Adenosine Monophosphate; Adrenergic alpha-Antagonists; Agmatine; Animals; Benzofurans; Cells, Cultur

2012
Effect of chronic morphine treatment on the biosynthesis of agmatine in rat brain and other tissues.
    Life sciences, 2002, Aug-23, Volume: 71, Issue:14

    Topics: Agmatine; Analgesics, Opioid; Animals; Brain; Brain Chemistry; Carboxy-Lyases; Male; Morphine; Morph

2002
Agmatine reduces only peripheral-related behavioral signs, not the central signs, of morphine withdrawal in nNOS deficient transgenic mice.
    Neuroscience letters, 2004, Jan-09, Volume: 354, Issue:2

    Topics: Agmatine; Animals; Behavior, Animal; Central Nervous System; Drug Interactions; Female; Male; Mice;

2004
Agmatine inhibits naloxone-induced contractions in morphine-dependent Guinea pig ileum.
    Annals of the New York Academy of Sciences, 2003, Volume: 1009

    Topics: Adrenergic alpha-Antagonists; Agmatine; Analgesics, Opioid; Animals; Dose-Response Relationship, Dru

2003
Effect of agmatine on the development of morphine dependence in rats: potential role of cAMP system.
    European journal of pharmacology, 2004, Nov-19, Volume: 504, Issue:3

    Topics: Agmatine; Animals; Cyclic AMP; In Vitro Techniques; Locus Coeruleus; Male; Morphine Dependence; Nalo

2004
Effect of agmatine on brain L-citrulline production during morphine withdrawal in rats: a microdialysis study in nucleus accumbens.
    Brain research, 2007, Feb-09, Volume: 1132, Issue:1

    Topics: Agmatine; Animals; Citrulline; Down-Regulation; Enzyme Inhibitors; Extracellular Fluid; Male; Microd

2007
Effects of intragastric agmatine on morphine-induced physiological dependence in beagle dogs and rhesus monkeys.
    European journal of pharmacology, 2008, Jun-10, Volume: 587, Issue:1-3

    Topics: Agmatine; Analgesics, Opioid; Animals; Behavior, Animal; Dogs; Dose-Response Relationship, Drug; Int

2008
Inhibitory effect of agmatine on naloxone-precipitated abstinence syndrome in morphine dependent rats.
    Life sciences, 1997, Volume: 61, Issue:18

    Topics: Agmatine; Animals; Behavior, Animal; Male; Morphine Dependence; Naloxone; Rats; Rats, Wistar; Substa

1997
Agmatine inhibited tolerance to and dependence on morphine in guinea pig ileum in vitro.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1998, Volume: 19, Issue:6

    Topics: Agmatine; Analgesics, Opioid; Animals; Drug Tolerance; Guinea Pigs; Ileum; Imidazoles; Imidazoline R

1998
Effects of agmatine on tolerance to and substance dependence on morphine in mice.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1999, Volume: 20, Issue:3

    Topics: Adrenergic alpha-Antagonists; Agmatine; Analgesics, Opioid; Animals; Drug Tolerance; Female; Idazoxa

1999
Correlation between inhibitions of morphine withdrawal and nitric-oxide synthase by agmatine.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1999, Volume: 20, Issue:4

    Topics: Agmatine; Animals; Brain; Male; Mice; Morphine Dependence; Nitric Oxide Synthase; Nitric Oxide Synth

1999
Down-regulation of MAO-B activity and imidazoline receptors in rat brain following chronic treatment of morphine.
    Acta pharmacologica Sinica, 2001, Volume: 22, Issue:7

    Topics: Agmatine; Animals; Brain; Chromatography, High Pressure Liquid; Down-Regulation; Idazoxan; Imidazoli

2001