agmatine has been researched along with Morphine Abuse in 17 studies
Agmatine: Decarboxylated arginine, isolated from several plant and animal sources, e.g., pollen, ergot, herring sperm, octopus muscle.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Agmatine is an imidazoline I(1) receptor endogenous ligand as well as its agonist, but more and more evidences suggest it has no influence on blood pressure." | 5.35 | Comparison of agmatine with moxonidine and rilmenidine in morphine dependence in vitro: role of imidazoline I(1) receptors. ( Li, F; Li, J; Liu, Y; Lu, XQ; Su, RB; Wu, N, 2009) |
| "Agmatine is an endogenous amine derived from arginine that potentiates morphine analgesia and blocks symptoms of naloxone-precipitated morphine withdrawal in rats." | 5.32 | Effect of agmatine on the development of morphine dependence in rats: potential role of cAMP system. ( Aricioglu, F; Means, A; Regunathan, S, 2004) |
| " In the present study, we investigated the role of agmatine in hippocampal neural progenitors in morphine dependence rats." | 3.88 | Agmatine inhibits chronic morphine exposure-induced impairment of hippocampal neural progenitor proliferation in adult rats. ( Chen, WQ; Li, J; Li, YF; Liu, Y; Lu, GY; Wu, N, 2018) |
| " In the present study, the effect of agmatine on the neuroadaptation of glutamate neurotransmission induced by morphine dependence, including changes of the extracellular glutamate level and glutamate receptors in the nucleus accumbens was investigated." | 3.77 | Agmatine modulates neuroadaptations of glutamate transmission in the nucleus accumbens of repeated morphine-treated rats. ( Li, J; Liu, Y; Lu, XQ; Su, RB; Wang, XF; Wu, N, 2011) |
| "Agmatine, an endogenous nitric oxide (NO) synthase inhibitor and ligand for imidazoline receptors, has been previously shown to prevent morphine dependence in rats." | 3.74 | Effect of agmatine on brain L-citrulline production during morphine withdrawal in rats: a microdialysis study in nucleus accumbens. ( Aricioğlu, F; Berkman, K; Gören, MZ; Yananli, H, 2007) |
| "Agmatine is an amine that is formed by decarboxylation of L-arginine by the enzyme arginine decarboxylase (ADC) and hydrolyzed by the enzyme agmatinase to putrescine." | 2.43 | Agmatine: biological role and therapeutic potentials in morphine analgesia and dependence. ( Regunathan, S, 2006) |
| "Agmatine itself was a weak analgesic which enhanced analgesic action of morphine and inhibited tolerance to and dependence on opioid." | 2.42 | A biphasic opioid function modulator: agmatine. ( Li, J; Qin, BY; Su, RB, 2003) |
| "Agmatine is an imidazoline I(1) receptor endogenous ligand as well as its agonist, but more and more evidences suggest it has no influence on blood pressure." | 1.35 | Comparison of agmatine with moxonidine and rilmenidine in morphine dependence in vitro: role of imidazoline I(1) receptors. ( Li, F; Li, J; Liu, Y; Lu, XQ; Su, RB; Wu, N, 2009) |
| " Both acute and chronic administration of agmatine reduced withdrawal signs in wild type mice and reduced only peripheral signs of morphine dependence in neuronal nitric oxide synthase knockout mice." | 1.32 | Agmatine reduces only peripheral-related behavioral signs, not the central signs, of morphine withdrawal in nNOS deficient transgenic mice. ( Aricioglu, F; Paul, IA; Regunathan, S, 2004) |
| "Agmatine is an endogenous amine derived from arginine that potentiates morphine analgesia and blocks symptoms of naloxone-precipitated morphine withdrawal in rats." | 1.32 | Effect of agmatine on the development of morphine dependence in rats: potential role of cAMP system. ( Aricioglu, F; Means, A; Regunathan, S, 2004) |
| "Agmatine is an endogenous amine derived from the decarboxylation of arginine by arginine decarboxylase (ADC), and metabolized to putrescine by agmatinase." | 1.31 | Effect of chronic morphine treatment on the biosynthesis of agmatine in rat brain and other tissues. ( Aricioglu-Kartal, F; Regunathan, S, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (23.53) | 18.2507 |
| 2000's | 10 (58.82) | 29.6817 |
| 2010's | 3 (17.65) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Y | 5 |
| Lu, GY | 1 |
| Chen, WQ | 1 |
| Li, YF | 1 |
| Wu, N | 5 |
| Li, J | 10 |
| Li, F | 2 |
| Su, RB | 5 |
| Lu, XQ | 3 |
| Wang, XF | 1 |
| Su, R | 1 |
| Chen, Y | 1 |
| Lu, X | 1 |
| Aricioglu-Kartal, F | 2 |
| Regunathan, S | 4 |
| Qin, BY | 5 |
| Aricioglu, F | 4 |
| Paul, IA | 1 |
| Ercil, E | 1 |
| Dulger, G | 1 |
| Means, A | 1 |
| Yananli, H | 1 |
| Gören, MZ | 1 |
| Berkman, K | 1 |
| Huang, Y | 1 |
| Gong, ZH | 1 |
| Wei, XL | 1 |
| Uzbay, IT | 1 |
| Li, X | 4 |
| Pei, G | 3 |
2 reviews available for agmatine and Morphine Abuse
| Article | Year |
|---|---|
A biphasic opioid function modulator: agmatine.
Topics: Agmatine; Analgesia; Analgesics, Opioid; Animals; Drug Interactions; Drug Tolerance; Morphine; Morph | 2003 |
Agmatine: biological role and therapeutic potentials in morphine analgesia and dependence.
Topics: Agmatine; Analgesia; Analgesics, Opioid; Animals; Drug Tolerance; Morphine; Morphine Dependence; Pai | 2006 |
15 other studies available for agmatine and Morphine Abuse
| Article | Year |
|---|---|
Agmatine inhibits chronic morphine exposure-induced impairment of hippocampal neural progenitor proliferation in adult rats.
Topics: Agmatine; Animals; Brain-Derived Neurotrophic Factor; Cell Proliferation; Cyclic AMP; Cyclic AMP Res | 2018 |
Comparison of agmatine with moxonidine and rilmenidine in morphine dependence in vitro: role of imidazoline I(1) receptors.
Topics: Agmatine; Animals; Antihypertensive Agents; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Dose-Resp | 2009 |
Agmatine modulates neuroadaptations of glutamate transmission in the nucleus accumbens of repeated morphine-treated rats.
Topics: Adaptation, Physiological; Agmatine; Animals; Biological Transport; Extracellular Space; Gene Expres | 2011 |
Imidazoline receptor antisera-selected/Nischarin regulates the effect of agmatine on the development of morphine dependence.
Topics: Adenosine Monophosphate; Adrenergic alpha-Antagonists; Agmatine; Animals; Benzofurans; Cells, Cultur | 2012 |
Effect of chronic morphine treatment on the biosynthesis of agmatine in rat brain and other tissues.
Topics: Agmatine; Analgesics, Opioid; Animals; Brain; Brain Chemistry; Carboxy-Lyases; Male; Morphine; Morph | 2002 |
Agmatine reduces only peripheral-related behavioral signs, not the central signs, of morphine withdrawal in nNOS deficient transgenic mice.
Topics: Agmatine; Animals; Behavior, Animal; Central Nervous System; Drug Interactions; Female; Male; Mice; | 2004 |
Agmatine inhibits naloxone-induced contractions in morphine-dependent Guinea pig ileum.
Topics: Adrenergic alpha-Antagonists; Agmatine; Analgesics, Opioid; Animals; Dose-Response Relationship, Dru | 2003 |
Effect of agmatine on the development of morphine dependence in rats: potential role of cAMP system.
Topics: Agmatine; Animals; Cyclic AMP; In Vitro Techniques; Locus Coeruleus; Male; Morphine Dependence; Nalo | 2004 |
Effect of agmatine on brain L-citrulline production during morphine withdrawal in rats: a microdialysis study in nucleus accumbens.
Topics: Agmatine; Animals; Citrulline; Down-Regulation; Enzyme Inhibitors; Extracellular Fluid; Male; Microd | 2007 |
Effects of intragastric agmatine on morphine-induced physiological dependence in beagle dogs and rhesus monkeys.
Topics: Agmatine; Analgesics, Opioid; Animals; Behavior, Animal; Dogs; Dose-Response Relationship, Drug; Int | 2008 |
Inhibitory effect of agmatine on naloxone-precipitated abstinence syndrome in morphine dependent rats.
Topics: Agmatine; Animals; Behavior, Animal; Male; Morphine Dependence; Naloxone; Rats; Rats, Wistar; Substa | 1997 |
Agmatine inhibited tolerance to and dependence on morphine in guinea pig ileum in vitro.
Topics: Agmatine; Analgesics, Opioid; Animals; Drug Tolerance; Guinea Pigs; Ileum; Imidazoles; Imidazoline R | 1998 |
Effects of agmatine on tolerance to and substance dependence on morphine in mice.
Topics: Adrenergic alpha-Antagonists; Agmatine; Analgesics, Opioid; Animals; Drug Tolerance; Female; Idazoxa | 1999 |
Correlation between inhibitions of morphine withdrawal and nitric-oxide synthase by agmatine.
Topics: Agmatine; Animals; Brain; Male; Mice; Morphine Dependence; Nitric Oxide Synthase; Nitric Oxide Synth | 1999 |
Down-regulation of MAO-B activity and imidazoline receptors in rat brain following chronic treatment of morphine.
Topics: Agmatine; Animals; Brain; Chromatography, High Pressure Liquid; Down-Regulation; Idazoxan; Imidazoli | 2001 |