agmatine has been researched along with Disease Models, Animal in 74 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (1.35) | 18.2507 |
| 2000's | 26 (35.14) | 29.6817 |
| 2010's | 36 (48.65) | 24.3611 |
| 2020's | 11 (14.86) | 2.80 |
| Authors | Studies |
|---|---|
| Braisted, J; Dranchak, P; Earnest, TW; Gu, X; Hoon, MA; Inglese, J; Oliphant, E; Solinski, HJ | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Gajda, M; Jawień, J; Kiepura, A; Kuś, K; Olszanecki, R; Stachowicz, A; Stachyra, K; Suski, M; Totoń-Żurańska, J; Ulatowska-Białas, M; Wiśniewska, A | 1 |
| Corrêa, T; da Silva-Santos, JE; de Souza, BS; França, AP; Izídio, GS; Prediger, RD; Schamne, MG | 1 |
| Abdelaziz, RR; Elmahdi, HS; Suddek, GM; Еlmahdy, MK | 1 |
| Bae, HJ; Chung, HJ; Gonzales, EL; Jeon, SJ; Kim, DH; Kim, J; Kwon, H; Ryu, JH; Shin, CY | 1 |
| Asadi-Shekaari, M; Asadikaram, G; Ganjalikhan-Hakemi, S; Nozari, M; Pourjafari, F | 1 |
| Aricioglu, F; Giris, M; Kucukali, CI; Sahin Ozkartal, C; Tuzun, E; Ulusoy, C | 1 |
| Deshmukh, R; Dixit, M; Fating, R; Kotagale, N; Taksande, B; Umekar, M | 1 |
| Avci, B; Bilge, SS; Bozkurt, A; Günaydin, C; Önger, ME | 1 |
| Chauragade, S; Chopde, C; Dixit, M; Kotagale, N; Rahmatkar, S; Taksande, B; Umekar, M | 1 |
| Hirasawa, Y; Matsumura, Y; Sugiura, T; Toyoshi, T | 1 |
| Akman, Ö; Arıcıoğlu, F; Ateş, N; Güllü, K; Karson, A; Utkan, T | 1 |
| El-Awady, MS; Nader, MA; Sharawy, MH | 1 |
| Azevedo, DP; Brocardo, PS; Fraga, DB; Gil-Mohapel, J; Melleu, FF; Neis, VB; Olescowicz, G; Rodrigues, ALS; Rosa, PB | 1 |
| Araslı, M; Barut, F; Ozacmak, HS; Ozacmak, VH; Turan, I | 1 |
| Bahremand, T; Dehpour, AR; Noorian, AR; Payandemehr, B; Payandemehr, P; Riazi, K; Sharifzadeh, M | 1 |
| Aydin, S; Cengelli Unel, C; Donertas, B; Erol, K; Kaygisiz, B; Ozatik, O; Ulupinar, E; Yildirim, E | 1 |
| de Souza, V; Farina, M; Gonçalves, CL; Guerra de Souza, AC; Hartwig, JM; Prediger, RD | 1 |
| Ahmed, A; El-Sayed, EK; Morsy, EE; Nofal, S | 1 |
| Andjus, P; Arsenijevic, L; Jovanovic, M; Jovanovic, N; Leontijevic, M; Radenkovic, M; Radenovic, L; Selakovic, V; Sivcev, S; Stojanovic, M | 1 |
| Evert, C; Gilbertsen, AJ; Hunter, RC; McCurtain, JL; Williams, BJ | 1 |
| Cynober, L; De Bandt, JP; Ramani, D | 1 |
| Daufenbach, J; Freitas, AE; Manosso, LM; Moretti, M; Neis, VB; Rodrigues, AL | 1 |
| Ammar, EM; El-Agamy, DS; Sharawy, MH | 1 |
| Bokara, KK; Cho, HJ; Hur, BE; Lee, JE; Lee, KM; Lee, WT; Park, KA; Song, J; Yang, W | 1 |
| Cakir, M; Coban, MK; Guclu, B; Kazanci, B; Sezer, A | 1 |
| Ahn, KJ; Ahn, SS; Choi, HS; Kim, DJ; Kim, J; Kim, SH; Lee, JE; Lee, SK; Shin, NY | 1 |
| Blackwell, TS; Dalluge, JJ; Gilbertsen, AJ; Han, W; Hughes, J; Laguna, TA; Paulson, NB; Welchlin, CW; Williams, BJ | 1 |
| Cheon, SY; Kam, EH; Kim, JM; Kim, SY; Koo, BN; Lee, JE; Lee, JH | 1 |
| Bugatti, A; Cagno, V; Cavalli, R; Chiuppesi, F; Donalisio, M; Ferruti, P; Lembo, D; Pistello, M; Quaranta, P; Ranucci, E; Rusnati, M; Volante, M | 1 |
| Blum-Silva, CH; Colle, D; Cunha, AS; Cunha, MP; Farina, M; Matheus, FC; Moretti, M; Poli, A; Prediger, RD; Reginatto, FH; Rodrigues, AL; Sampaio, TB; Sandjo, LP; Santos, DB | 1 |
| Aras, M; Cabuk, M; Can, M; Elri, T; Gulle, K; Ozacmak, HS; Salihoglu, YS | 1 |
| Banerjee, S; Gonzales, ELT; Han, SH; Kim, JW; Kim, KC; Ko, MJ; Oh, HA; Seung, H; Shin, CY; Yang, SM | 1 |
| Akar, A; Aydin, IH; Erdogan, F; Kadioglu, HH; Malcok, UA; Sengul, G; Takci, E | 1 |
| Cheng, JT; Chung, HH; Ko, WC; Liu, IM | 1 |
| Li, J; Liu, ZM; Lu, XQ; Su, RB; Wang, WP; Wu, N | 1 |
| Cheng, JT; Chung, HH; Liu, IM; Su, CH | 1 |
| Hong, S; Kim, CY; Lee, WS; Seong, GJ; Shim, J; Yeom, HY | 1 |
| Jiang, XZ; Li, J; Li, YF; Liu, YQ; Zhang, LM; Zhang, YZ | 1 |
| Bahremand, A; Dehpour, AR; Ghasemi, A; Ghasemi, M; Hedayat, T; Khodadad, TK; Payandemehr, B; Rahimian, R; Ziai, P | 1 |
| Ahn, SK; Hong, S; Lee, JE; Lee, WT; Park, KA; Park, YM | 1 |
| Cowan, A; Hirsch, DD; Kim, J; Lisek, R; Rawls, SM; Raymondi, N; Rosenthal, A | 1 |
| Kim, JH; Lee, JE; Lee, WT; Lee, YW; Park, KA; Park, SH; Park, YM | 1 |
| Dehpour, AR; Hojati, A; Moezi, L; Shafaroodi, H | 1 |
| Li, JX; Winter, JC; Zhang, Y | 1 |
| Chopde, CT; Gawande, DY; Hadole, PN; Kotagale, NR; Mendhi, SM; Palhade, MW; Taksande, BG; Wadhwani, PJ | 1 |
| Bao, YX; Fan, X; Gu, Y; Liang, HP; Yang, X; Zhang, C | 1 |
| Hara, H; Hong, S; Hyakkoku, K; Kim, CY; Seong, GJ; Shimazawa, M | 1 |
| Al Masri, AA; El Eter, E | 1 |
| Aguiar, AS; Castro, AA; Ferreira, J; Figueiredo, CP; Matheus, FC; Prediger, RD; Santos, AR; Tasca, CI; Villarinho, JG; Walz, R | 1 |
| Chen, MF; Cheng, JT; Chiu, NH; Chou, MT; Chung, HH; Mar, GY | 1 |
| Colombatto, S; Dudkowska, M; Gardini, G; Grzelakowska-Sztabert, B; Lai, J; Manteuffel-Cymborowska, M; Stachurska, A | 1 |
| Dominiak, P; Häuser, W; Jungbluth, B; Raasch, W; Schäfer, U | 1 |
| Li, J; Liu, Y; Su, RB; Wei, XL | 1 |
| Fairbanks, CA; Wilcox, GL; Yezierski, RP; Yu, CG | 1 |
| Cho, SW; Giffard, RG; Kim, JH; Lee, JE; Park, KA; Yenari, MA | 1 |
| Calixto, JB; Dias Elpo Zomkowski, A; Lin, J; Lúcia Severo Rodrigues, A; Oscar Rosa, A; Santos, AR | 1 |
| Rodrigues, AL; Santos, AR; Zomkowski, AD | 2 |
| Feng, Y; LeBlanc, MH; Regunathan, S | 1 |
| Berenholz, L; Eviatar, E; Gilad, GM; Gilad, VH; Kessler, A; Klein, C; Segal, S; Yehezkeli, E | 1 |
| Chung, TS; Kim, DI; Kim, DJ; Kim, J; Lee, JE; Lee, SK; Lee, YJ; Suh, SH | 1 |
| Akçetin, M; Bilge, T; Kirali, M; Kotil, K; Kuscuoglu, U; Uzun, H | 1 |
| Benedek, G; Horvath, G; Kekesi, G; Tuboly, G | 1 |
| Calixto, JB; Gadotti, VM; Paszcuk, AF; Quintão, NL; Rodrigues, AL; Santos, AR; Tibola, D | 1 |
| Anderson, JR; Jones, BW; Kinard, K; Lucas, RJ; Marc, RE; Marshak, DW; Wensel, T; Wilson, JH | 1 |
| Chang, CP; Chio, CC; Kuo, JR; Lin, MT; Lo, CJ | 1 |
| Barron, S; Lewis, B; Wellmann, KA | 1 |
| Jia, LS; Song, DW; Xing, WX | 1 |
| Krass, M; Vasar, E; Volke, V; Wegener, G | 1 |
| Gilad, GM; Gilad, VH; Rabey, JM; Salame, K | 1 |
| Fairbanks, CA; Marcillo, AE; Wilcox, GL; Yezierski, RP; Yu, CG | 1 |
| Calixto, JB; Hammes, L; Lin, J; Rodrigues, AL; Santos, AR; Zomkowski, AD | 1 |
1 review(s) available for agmatine and Disease Models, Animal
| Article | Year |
|---|---|
Aliphatic polyamines in physiology and diseases.
Topics: Agmatine; Animals; Disease Models, Animal; Humans; Neoplasms; Ornithine; Putrescine; Spermidine; Spermine | 2014 |
1 trial(s) available for agmatine and Disease Models, Animal
| Article | Year |
|---|---|
Neuroprotective effects of agmatine in experimental peripheral nerve injury in rats: a prospective randomized and placebo-controlled trial.
Topics: Agmatine; Animals; Disease Models, Animal; Male; Neuroprotective Agents; Nitric Oxide Synthase Type II; Peripheral Nerve Injuries; Prospective Studies; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sciatic Nerve | 2014 |
72 other study(ies) available for agmatine and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Inhibition of Atherosclerosis and Liver Steatosis by Agmatine in Western Diet-Fed apoE-Knockout Mice Is Associated with Decrease in Hepatic De Novo Lipogenesis and Reduction in Plasma Triglyceride/High-Density Lipoprotein Cholesterol Ratio.
Topics: Agmatine; Animals; Atherosclerosis; Biomarkers; Cholesterol, HDL; Diet, Western; Disease Models, Animal; Disease Susceptibility; Fatty Liver; Female; Immunohistochemistry; Lipid Metabolism; Lipids; Lipogenesis; Mice; Mice, Knockout, ApoE; Triglycerides | 2021 |
Agmatine improves olfactory and cognitive deficits in Spontaneously Hypertensive Rats (SHR): An animal model of Attention Deficit Hyperactivity Disorder (ADHD).
Topics: Adult; Agmatine; Animals; Attention Deficit Disorder with Hyperactivity; Cognition; Cognitive Dysfunction; Disease Models, Animal; Humans; Male; Rats; Rats, Inbred SHR; Rats, Wistar | 2022 |
Effect of Agmatine on a mouse model of allergic airway inflammation: A comparative study.
Topics: Agmatine; Animals; Anti-Asthmatic Agents; Beclomethasone; Cytokines; Disease Models, Animal; Inflammation; Interleukin-13; Interleukin-5; Lung; Malondialdehyde; Mice; Mice, Inbred BALB C; Nitrates; Nitrites; Ovalbumin; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2022 |
Agmatine relieves behavioral impairments in Fragile X mice model.
Topics: Agmatine; Animals; Calcium Carbonate; Disease Models, Animal; Fragile X Mental Retardation Protein; Fragile X Syndrome; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Polyamines; Valproic Acid | 2022 |
Agmatine improves liver function, balance performance, and neuronal damage in a hepatic encephalopathy induced by bile duct ligation.
Topics: Agmatine; Animals; Bile Ducts; Disease Models, Animal; Hepatic Encephalopathy; Rats; Rats, Wistar | 2023 |
Antidepressant-like effects of agmatine and NOS inhibitors in chronic unpredictable mild stress model of depression in rats: The involvement of NLRP inflammasomes.
Topics: Agmatine; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Inflammasomes; Male; Nitric Oxide Synthase; NLR Proteins; Rats, Sprague-Dawley; RNA, Messenger; Stress, Psychological | 2019 |
Agmatine ameliorates manifestation of depression-like behavior and hippocampal neuroinflammation in mouse model of Alzheimer's disease.
Topics: Agmatine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Depression; Disease Models, Animal; Hippocampus; Inflammation Mediators; Male; Mice; Peptide Fragments | 2020 |
Neuroprotective action of agmatine in rotenone-induced model of Parkinson's disease: Role of BDNF/cREB and ERK pathway.
Topics: Agmatine; Animals; Apoptosis; Brain; Brain-Derived Neurotrophic Factor; Cell Survival; Corpus Striatum; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Male; MAP Kinase Signaling System; Neuronal Plasticity; Neurons; Neuroprotection; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone; Signal Transduction | 2020 |
Involvement of hippocampal agmatine in β
Topics: Agmatine; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cognition; Disease Models, Animal; Hippocampus; Inflammation Mediators; Male; Maze Learning; Memory; Memory Disorders; Mice; Nootropic Agents; Open Field Test; Peptide Fragments; Signal Transduction | 2020 |
Effects of Agmatine on Contrast-Induced Nephropathy in Rats and Rabbits.
Topics: Acute Kidney Injury; Agmatine; Animals; Contrast Media; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Nitric Oxide Synthase; Rabbits; Rats; Rats, Sprague-Dawley; Treatment Outcome | 2020 |
Agmatine has beneficial effect on harmaline-induced essential tremor in rat.
Topics: Agmatine; Animals; Central Nervous System Stimulants; Disease Models, Animal; Essential Tremor; Harmaline; Humans; Male; Neuroprotective Agents; Rats; Severity of Illness Index | 2021 |
The inhibition of inducible nitric oxide synthase and oxidative stress by agmatine attenuates vascular dysfunction in rat acute endotoxemic model.
Topics: Agmatine; Animals; Antioxidants; Disease Models, Animal; Down-Regulation; Endothelium, Vascular; Endotoxemia; Gene Expression Regulation, Enzymologic; Lipid Peroxidation; Lipopolysaccharides; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2017 |
Antidepressant and pro-neurogenic effects of agmatine in a mouse model of stress induced by chronic exposure to corticosterone.
Topics: Agmatine; Anhedonia; Animals; Antidepressive Agents; Cell Proliferation; Corticosterone; Depressive Disorder; Disease Models, Animal; Female; Fluoxetine; Hippocampus; Mice; Motor Activity; Neurogenesis; Neuronal Plasticity; Random Allocation; Stress, Psychological | 2018 |
Agmatine attenuates intestinal ischemia and reperfusion injury by reducing oxidative stress and inflammatory reaction in rats.
Topics: Agmatine; Animals; Carbachol; Disease Models, Animal; Inflammation; Intestine, Small; Male; Malondialdehyde; Oxidative Stress; Peroxidase; Potassium Chloride; Rats; Rats, Wistar; Reperfusion Injury | 2017 |
Modulation of the anticonvulsant effect of swim stress by agmatine.
Topics: Agmatine; Analgesics, Opioid; Animals; Anticonvulsants; Arginine; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pentylenetetrazole; Seizures; Signal Transduction; Swimming | 2018 |
Agmatine co-treatment attenuates allodynia and structural abnormalities in cisplatin-induced neuropathy in rats.
Topics: Agmatine; Analgesics; Animals; Animals, Newborn; Behavior, Animal; Cells, Cultured; Cisplatin; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Ganglia, Spinal; Hyperalgesia; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peripheral Nervous System Diseases; Primary Cell Culture; Rats, Sprague-Dawley; Sciatic Nerve | 2018 |
Agmatine attenuates depressive-like behavior and hippocampal oxidative stress following amyloid β (Aβ1-40) administration in mice.
Topics: Agmatine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antidepressive Agents; Antioxidants; Depression; Disease Models, Animal; Hippocampus; Humans; Male; Mice; Oxidative Stress; Peptide Fragments | 2018 |
Neuroprotective effect of agmatine (decarboxylated l-arginine) against oxidative stress and neuroinflammation in rotenone model of Parkinson's disease.
Topics: Agmatine; Animals; Cytokines; Disease Models, Animal; Glial Fibrillary Acidic Protein; Glutathione; Male; Malondialdehyde; Mesencephalon; Neuroprotective Agents; Oxidative Stress; Parkinson Disease, Secondary; Rats, Sprague-Dawley; Rotenone; Tyrosine 3-Monooxygenase | 2019 |
Functional and pharmacological analysis of agmatine administration in different cerebral ischemia animal models.
Topics: Agmatine; Animals; Brain; Brain Ischemia; Carotid Artery, Common; Disease Models, Animal; Gerbillinae; Lipid Peroxidation; Male; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2019 |
Agmatine accumulation by Pseudomonas aeruginosa clinical isolates confers antibiotic tolerance and dampens host inflammation.
Topics: Adaptation, Physiological; Agmatine; Animals; Anti-Bacterial Agents; Cystic Fibrosis; Disease Models, Animal; Drug Resistance, Bacterial; Epithelial Cells; Female; Humans; Hydrolases; Inflammation; Mice; Microbial Sensitivity Tests; Mutation; Neutrophils; Phenotype; Pneumonia, Bacterial; Pseudomonas aeruginosa; Pseudomonas Infections; Sputum | 2019 |
Depressive-like behavior induced by tumor necrosis factor-α is abolished by agmatine administration.
Topics: Agmatine; Analysis of Variance; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Hindlimb Suspension; Immobility Response, Tonic; Indazoles; Mice; Tumor Necrosis Factor-alpha | 2014 |
Agmatine attenuates silica-induced pulmonary fibrosis.
Topics: Agmatine; Animals; Biomarkers; Bronchoalveolar Lavage Fluid; Cytoprotection; Disease Models, Animal; Enzyme Inhibitors; Glutathione; Hydroxyproline; Lipid Peroxidation; Lung; Male; Malondialdehyde; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Pneumonia; Pulmonary Edema; Pulmonary Fibrosis; Rats, Sprague-Dawley; Silicon Dioxide; Superoxide Dismutase; Time Factors | 2014 |
Agmatine improves cognitive dysfunction and prevents cell death in a streptozotocin-induced Alzheimer rat model.
Topics: Agmatine; Alzheimer Disease; Animals; Cognition Disorders; Disease Models, Animal; Male; Rats; Streptozocin | 2014 |
Effects of agmatine on blood-brain barrier stabilization assessed by permeability MRI in a rat model of transient cerebral ischemia.
Topics: Agmatine; Animals; Blood-Brain Barrier; Capillary Permeability; Disease Models, Animal; Infarction, Middle Cerebral Artery; Magnetic Resonance Imaging; Male; Rats; Rats, Sprague-Dawley | 2015 |
The arginine decarboxylase pathways of host and pathogen interact to impact inflammatory pathways in the lung.
Topics: Agmatine; Animals; Biofilms; Carboxy-Lyases; Chromatography, High Pressure Liquid; Disease Models, Animal; Female; Host-Pathogen Interactions; Humans; Inflammation; Longitudinal Studies; Lung; Mice; Mice, Inbred BALB C; Mutagenesis; Mutation; NF-kappa B; Nitric Oxide Synthase; Phenotype; Pneumonia, Bacterial; Prospective Studies; Pseudomonas aeruginosa; Sputum | 2014 |
The Anti-inflammatory Effects of Agmatine on Transient Focal Cerebral Ischemia in Diabetic Rats.
Topics: Agmatine; Animals; Blotting, Western; Brain; Diabetes Mellitus, Experimental; Disease Models, Animal; Inflammation; Ischemic Attack, Transient; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction | 2016 |
The AGMA1 poly(amidoamine) inhibits the infectivity of herpes simplex virus in cell lines, in human cervicovaginal histocultures, and in vaginally infected mice.
Topics: Agmatine; Animals; Anti-Infective Agents, Local; Antiviral Agents; Cell Survival; Cervix Uteri; Chlorocebus aethiops; Disease Models, Animal; Female; Herpes Simplex; Herpesvirus 1, Human; Herpesvirus 2, Human; Human papillomavirus 16; Humans; Mice; Mice, Inbred C57BL; Polyamines; Vero Cells | 2016 |
Agmatine attenuates reserpine-induced oral dyskinesia in mice: Role of oxidative stress, nitric oxide and glutamate NMDA receptors.
Topics: Agmatine; Animals; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Dizocilpine Maleate; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Dopamine Plasma Membrane Transport Proteins; Dyskinesia, Drug-Induced; Dyskinesias; Excitatory Amino Acid Antagonists; Locomotion; Male; Mice; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate; Reserpine; Tyrosine 3-Monooxygenase | 2016 |
Evaluation of the protective effect of agmatine against cisplatin nephrotoxicity with 99mTc-DMSA renal scintigraphy and cystatin-C.
Topics: Acute Kidney Injury; Agmatine; Animals; Cisplatin; Cystatin C; Disease Models, Animal; Female; Kidney; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Wistar; Technetium Tc 99m Dimercaptosuccinic Acid | 2016 |
Agmatine rescues autistic behaviors in the valproic acid-induced animal model of autism.
Topics: Agmatine; Animals; Autism Spectrum Disorder; Disease Models, Animal; Grooming; Hippocampus; Hyperkinesis; Male; MAP Kinase Signaling System; Mice; Mice, Transgenic; Neural Stem Cells; Neurons; Prefrontal Cortex; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures; Social Behavior; Valproic Acid | 2017 |
A preliminary histopathological study of the effect of agmatine on diffuse brain injury in rats.
Topics: Agmatine; Animals; Axons; Brain; Brain Injuries; Cerebrovascular Circulation; Disease Models, Animal; Head Injuries, Closed; Male; Neurons; Neuroprotective Agents; Neurotransmitter Agents; Random Allocation; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Time Factors; Treatment Outcome | 2008 |
Activation of I(2)-imidazoline receptors may ameliorate insulin resistance in fructose-rich chow-fed rats.
Topics: Agmatine; Analysis of Variance; Animals; Area Under Curve; Behavior, Animal; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Diet; Disease Models, Animal; Dose-Response Relationship, Drug; Fructose; Imidazoles; Imidazoline Receptors; Insulin; Insulin Resistance; Ligands; Male; Rats; Rats, Wistar | 2008 |
Agmatine blocks acquisition and re-acquisition of intravenous morphine self-administration in rats.
Topics: Agmatine; Animals; Disease Models, Animal; Extinction, Psychological; Infusions, Intravenous; Male; Morphine; Narcotics; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration; Substance-Related Disorders | 2009 |
Activation of I2-imidazoline receptors by agmatine improved insulin sensitivity through two mechanisms in type-2 diabetic rats.
Topics: Adrenalectomy; Agmatine; Analysis of Variance; Animals; beta-Endorphin; Blood Glucose; Diabetes Mellitus, Type 2; Diet; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Fructose; Glucose Clamp Technique; Hypoglycemic Agents; Imidazoles; Imidazoline Receptors; Insulin; Insulin Resistance; Male; Rats; Rats, Wistar | 2009 |
Ocular hypotensive effects of topically administered agmatine in a chronic ocular hypertensive rat model.
Topics: Administration, Topical; Agmatine; Animals; Antihypertensive Agents; Cell Count; Chronic Disease; Disease Models, Animal; Intraocular Pressure; Male; Neuroprotective Agents; Ocular Hypertension; Ophthalmic Solutions; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells | 2010 |
[Neonatal fluoxetine exposure induced depression-like behaviors in adult Kunming mice and the antidepressant-like effect of agmatine].
Topics: Agmatine; Animals; Antidepressive Agents; Depressive Disorder; Disease Models, Animal; Female; Fluoxetine; Male; Mice; Mice, Inbred Strains | 2009 |
Agmatine enhances the anticonvulsant effect of lithium chloride on pentylenetetrazole-induced seizures in mice: Involvement of L-arginine/nitric oxide pathway.
Topics: Agmatine; Analysis of Variance; Animals; Antidepressive Agents; Arginine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Indazoles; Lithium Chloride; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pentylenetetrazole; Seizures; Signal Transduction | 2010 |
Effects of agmatine on hypoxic microglia and activity of nitric oxide synthase.
Topics: Agmatine; Analysis of Variance; Animals; Calcium-Binding Proteins; Cell Hypoxia; Cell Line, Transformed; Cerebrovascular Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Infarction, Middle Cerebral Artery; L-Lactate Dehydrogenase; Male; Mice; Microfilament Proteins; Microglia; Nitric Oxide Synthase Type II; Nitrites; Prosencephalon; Rats; Rats, Sprague-Dawley | 2011 |
Icilin-evoked behavioral stimulation is attenuated by alpha₂-adrenoceptor activation.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Agmatine; Analysis of Variance; Animals; Behavior, Animal; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Head Movements; Male; Movement Disorders; Pyrimidinones; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Time Factors; Yohimbine | 2011 |
Agmatine-reduced collagen scar area accompanied with surface righting reflex recovery after complete transection spinal cord injury.
Topics: Agmatine; Animals; Bone Morphogenetic Protein 7; Cicatrix; Collagen; Disease Models, Animal; Immunohistochemistry; Male; Mice; Mice, Inbred ICR; Motor Activity; Recovery of Function; Reflex, Righting; Spinal Cord; Spinal Cord Injuries; Thoracic Vertebrae; Transforming Growth Factor beta2 | 2011 |
The interaction of melatonin and agmatine on pentylenetetrazole-induced seizure threshold in mice.
Topics: Agmatine; Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Male; Melatonin; Mice; Pentylenetetrazole; Prazosin; Receptors, Melatonin; Seizures; Time Factors; Tryptamines | 2011 |
Morphine-induced antinociception in the rat: supra-additive interactions with imidazoline I₂ receptor ligands.
Topics: Adrenergic alpha-2 Receptor Antagonists; Agmatine; Analgesics; Analgesics, Opioid; Animals; Benzofurans; Disease Models, Animal; Drug Synergism; Idazoxan; Imidazoles; Imidazoline Receptors; Ligands; Male; Morphine; Pain; Rats; Rats, Sprague-Dawley; Saline Solution, Hypertonic; Yohimbine | 2011 |
Psychopharmacological study of agmatine in behavioral tests of schizophrenia in rodents.
Topics: Agmatine; Animals; Antipsychotic Agents; Avoidance Learning; Behavior, Animal; Catalepsy; Disease Models, Animal; Dopamine Agents; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Dyskinesia, Drug-Induced; Male; Mice; Molecular Targeted Therapy; Prolactin; Random Allocation; Rats; Rats, Sprague-Dawley; Schizophrenia | 2012 |
[The protective effects of agmatine in zymosan induced acute lung injury in mice].
Topics: Acute Lung Injury; Agmatine; Animals; Disease Models, Animal; Inflammation; Interleukin-6; Lung; Male; Mice; Mice, Inbred C57BL; Tumor Necrosis Factor-alpha; Zymosan | 2011 |
Retinal protective effects of topically administered agmatine on ischemic ocular injury caused by transient occlusion of the ophthalmic artery.
Topics: Agmatine; Animals; Arterial Occlusive Diseases; Disease Models, Animal; Ischemia; Male; Mice; Neuroprotective Agents; Ophthalmic Artery; Retinal Diseases | 2012 |
Agmatine induces gastric protection against ischemic injury by reducing vascular permeability in rats.
Topics: Agmatine; Androstadienes; Angiopoietin-1; Angiopoietin-2; Animals; Capillary Permeability; Chemokine CCL2; Cytoprotection; Disease Models, Animal; Down-Regulation; Gastric Mucosa; Immunohistochemistry; Male; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Protective Agents; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Reperfusion Injury; Stomach; Vascular Endothelial Growth Factor A; Wortmannin | 2012 |
Neuroprotective effects of agmatine in mice infused with a single intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Administration, Intranasal; Agmatine; Analysis of Variance; Animals; Disease Models, Animal; Dopaminergic Neurons; Drug Administration Schedule; Drug Interactions; Exploratory Behavior; Female; Glutamic Acid; Hippocampus; Mice; Mice, Inbred C57BL; Motor Activity; Neurologic Examination; Neuroprotective Agents; Parkinsonian Disorders; Recognition, Psychology; Social Behavior; Substantia Nigra; Survival Analysis; Tritium; Tyrosine 3-Monooxygenase | 2012 |
Changes of imidazoline receptors in spontaneously hypertensive rats.
Topics: Agmatine; Animals; Antihypertensive Agents; Aorta, Thoracic; Benzofurans; Blood Pressure; Blotting, Western; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Hypertension; Imidazoles; Imidazoline Receptors; KATP Channels; Male; Potassium Channel Blockers; Protein Kinase Inhibitors; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Up-Regulation; Vasodilation; Vasodilator Agents | 2013 |
Agmatine modulates the in vivo biosynthesis and interconversion of polyamines and cell proliferation.
Topics: Acetyltransferases; Agmatine; Animals; Cell Division; Disease Models, Animal; DNA Replication; Epithelial Cells; Eukaryotic Initiation Factor-4E; Folic Acid Antagonists; Kidney Diseases; Mice; Ornithine Decarboxylase; Polyamines; Protein Biosynthesis; Proteins | 2003 |
Modification of noradrenaline release in pithed spontaneously hypertensive rats by I1-binding sites in addition to alpha2-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Agmatine; Animals; Antihypertensive Agents; Benzofurans; Binding Sites; Blood Pressure; Disease Models, Animal; Heart Rate; Idazoxan; Imidazoles; Male; Norepinephrine; Phenoxybenzamine; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2 | 2003 |
Antimalarial effect of agmatine on Plasmodium berghei K173 strain.
Topics: Agmatine; Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Resistance; Eflornithine; Female; Malaria; Male; Mice; Ornithine Decarboxylase Inhibitors; Parasitemia; Parasitic Sensitivity Tests; Plasmodium berghei | 2003 |
Effects of agmatine, interleukin-10, and cyclosporin on spontaneous pain behavior after excitotoxic spinal cord injury in rats.
Topics: Agmatine; Animals; Cyclosporine; Disease Models, Animal; Excitatory Amino Acid Agonists; Grooming; Immunosuppressive Agents; Interleukin-10; Male; Pain; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries; Time Factors | 2003 |
Agmatine reduces infarct area in a mouse model of transient focal cerebral ischemia and protects cultured neurons from ischemia-like injury.
Topics: Agmatine; Analysis of Variance; Animals; Animals, Newborn; Blotting, Western; Brain Infarction; Cell Count; Cell Hypoxia; Cells, Cultured; Disease Models, Animal; Functional Laterality; Gene Expression Regulation; Glucose; Hypoxia; Immunohistochemistry; Ischemic Attack, Transient; L-Lactate Dehydrogenase; Male; Mice; Mice, Inbred ICR; Neurons; Neuroprotective Agents; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitrites; Tetrazolium Salts; Time Factors | 2004 |
Evidence for serotonin receptor subtypes involvement in agmatine antidepressant like-effect in the mouse forced swimming test.
Topics: Agmatine; Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Fenclonine; Fluoxetine; Immobility Response, Tonic; Male; Methysergide; Mice; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Serotonin Receptor Agonists; Swimming | 2004 |
Evidence for the involvement of the opioid system in the agmatine antidepressant-like effect in the forced swimming test.
Topics: Agmatine; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Female; Male; Mice; Motor Activity; Narcotic Antagonists; Receptors, Opioid; Swimming | 2005 |
Agmatine reduces extracellular glutamate during pentylenetetrazole-induced seizures in rat brain: a potential mechanism for the anticonvulsive effects.
Topics: Agmatine; Animals; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Drug Interactions; Extracellular Space; Glutamic Acid; Male; Microdialysis; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Time Factors | 2005 |
Agmatine treatment and vein graft reconstruction enhance recovery after experimental facial nerve injury.
Topics: Agmatine; Analysis of Variance; Animals; Disease Models, Animal; Electric Stimulation; Facial Nerve Injuries; Immunohistochemistry; Male; Neural Conduction; Neurofilament Proteins; Rats; Rats, Sprague-Dawley; Reaction Time; Recovery of Function; Time Factors; Transplantation, Autologous; Treatment Outcome; Veins; Vibrissae | 2005 |
Protective effect of agmatine on a reperfusion model after transient cerebral ischemia: Temporal evolution on perfusion MR imaging and histopathologic findings.
Topics: Agmatine; Animals; Cats; Cerebrovascular Circulation; Disease Models, Animal; Ischemic Attack, Transient; Magnetic Resonance Imaging; Time Factors | 2006 |
Investigation of the dose-dependent neuroprotective effects of agmatine in experimental spinal cord injury: a prospective randomized and placebo-control trial.
Topics: Agmatine; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Laminectomy; Lipid Peroxidation; Male; Malondialdehyde; Motor Activity; Motor Skills; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; Postural Balance; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Spinal Cord Injuries; Thiobarbituric Acid Reactive Substances | 2006 |
Putrescine produces antidepressant-like effects in the forced swimming test and in the tail suspension test in mice.
Topics: Agmatine; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Female; Imipramine; Immobilization; Male; Mice; Putrescine; Restraint, Physical; Swimming; Tail | 2006 |
Antinociceptive interactions of triple and quadruple combinations of endogenous ligands at the spinal level.
Topics: Adenosine; Agmatine; Analgesics; Animals; Area Under Curve; Disease Models, Animal; Drug Combinations; Injections, Spinal; Kynurenic Acid; Ligands; Male; Motor Activity; Oligopeptides; Pain; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Opioid, mu; Spinal Cord | 2007 |
Anti-hypernociceptive properties of agmatine in persistent inflammatory and neuropathic models of pain in mice.
Topics: Agmatine; Analgesics; Analysis of Variance; Animals; Behavior, Animal; Cytokines; Disease Models, Animal; Edema; Female; Freund's Adjuvant; Inflammation; Mice; Neutrophils; Pain; Pain Measurement; Peroxidase; Sciatic Neuropathy | 2007 |
Neural reprogramming in retinal degeneration.
Topics: Agmatine; Amacrine Cells; Animals; Disease Models, Animal; Female; Humans; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Mutant Strains; Neuronal Plasticity; Papio anubis; Phenotype; Receptors, AMPA; Receptors, Metabotropic Glutamate; Retinal Bipolar Cells; Retinal Cone Photoreceptor Cells; Retinal Degeneration; Retinal Ganglion Cells; Retinal Rod Photoreceptor Cells | 2007 |
Resuscitation from experimental traumatic brain injury by agmatine therapy.
Topics: Agmatine; Animals; Brain Injuries; Disease Models, Animal; Glutamic Acid; Hippocampus; Infusions, Parenteral; Male; Microdialysis; Neuroprotective Agents; Nitric Oxide; Rats; Rats, Sprague-Dawley; Resuscitation; Time Factors | 2007 |
Agmatine reduces balance deficits in a rat model of third trimester binge-like ethanol exposure.
Topics: Agmatine; Alcoholism; Animals; Animals, Newborn; Area Under Curve; Body Weight; Central Nervous System Depressants; Cerebellum; Disease Models, Animal; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Humans; Male; Postural Balance; Pregnancy; Pregnancy Trimester, Third; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2007 |
[Concentration of endogenous agmatine in normal and injured spinal cord: experiment with rats].
Topics: Agmatine; Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Nitric Oxide Synthase; Random Allocation; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries | 2007 |
Antidepressant-like effect of agmatine is not mediated by serotonin.
Topics: Agmatine; Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Fenclonine; Hydroxyindoleacetic Acid; Imipramine; Immobility Response, Tonic; Male; Mice; Mice, Inbred C57BL; Motor Activity; Serotonin; Swimming | 2008 |
Agmatine treatment is neuroprotective in rodent brain injury models.
Topics: Agmatine; Animals; Brain Injuries; Brain Ischemia; Cells, Cultured; Disease Models, Animal; Gerbillinae; Male; Neurons; Rats; Rats, Wistar | 1996 |
Agmatine improves locomotor function and reduces tissue damage following spinal cord injury.
Topics: Agmatine; Animals; Disease Models, Animal; Female; Gait Disorders, Neurologic; Myelitis; Nerve Degeneration; Neuroprotective Agents; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Recovery of Function; Spinal Cord Injuries | 2000 |
Agmatine produces antidepressant-like effects in two models of depression in mice.
Topics: Agmatine; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Imipramine; Male; Mice; Nitric Oxide Synthase; Receptors, N-Methyl-D-Aspartate | 2002 |