agmatine has been researched along with Depression in 30 studies
Agmatine: Decarboxylated arginine, isolated from several plant and animal sources, e.g., pollen, ergot, herring sperm, octopus muscle.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To examine the possible role of impramine and agmatine through a mTOR signal pathway on rat ovary after maternal separation stress-induced depression." | 8.31 | The effect of maternal separation stress-induced depression on ovarian reserve in Sprague Dawley Rats: The possible role of imipramine and agmatine through a mTOR signal pathway. ( Arıcıoğlu, F; Önel, T; Yaba, A; Yıldırım, E; Zortul, H, 2023) |
| "Agmatine is an endogenous polyamine synthesized by the enzyme arginine decarboxylase." | 6.53 | Agmatine, a potential novel therapeutic strategy for depression. ( Freitas, AE; Neis, VB; Rodrigues, ALS, 2016) |
| "Agmatine levels were significantly reduced in the hippocampus of T2DM rats as compared to the normal fed (NF) control animals." | 5.56 | Agmatine modulates anxiety and depression-like behaviour in diabetic insulin-resistant rats. ( Aglawe, MM; Kale, M; Kotagale, N; Nimje, N; Taksande, B; Umekar, M, 2020) |
| "Epilepsy is fourth most common neurological disorders associated with depression and cognitive deficits." | 5.46 | Agmatine for combined treatment of epilepsy, depression and cognitive impairment in chronic epileptic animals. ( Bagga, N; Gawande, DY; Goel, RK; Kaur, A; Kaur, N; Singh, T, 2017) |
| "Agmatine, an endogenous neuromodulator, is a potential candidate to constitute an adjuvant/monotherapy for the management of depression." | 3.83 | Agmatine, by Improving Neuroplasticity Markers and Inducing Nrf2, Prevents Corticosterone-Induced Depressive-Like Behavior in Mice. ( Buendia, I; Casas, AI; Cuadrado, A; Egea, J; Freitas, AE; Gómez-Rangel, V; Lopez, MG; Navarro, E; Ortiz, JA; Parada, E; Rodrigues, ALS; Ruiz-Nuño, A; Wojnicz, A, 2016) |
| "Agmatine has been recently emerged as a novel candidate to assist the conventional pharmacotherapy of depression." | 3.80 | Agmatine abolishes restraint stress-induced depressive-like behavior and hippocampal antioxidant imbalance in mice. ( Bettio, LE; Farina, M; Freitas, AE; Neis, VB; Ribeiro, CM; Rodrigues, AL; Rosa, PB; Santos, DB, 2014) |
| "Putrescine, a polyamine present at high concentrations in the mammalian brain, was suggested to play a role in the modulation of depression." | 3.73 | Putrescine produces antidepressant-like effects in the forced swimming test and in the tail suspension test in mice. ( Rodrigues, AL; Santos, AR; Zomkowski, AD, 2006) |
| "Agmatine is an endogenous polyamine synthesized by the enzyme arginine decarboxylase." | 2.53 | Agmatine, a potential novel therapeutic strategy for depression. ( Freitas, AE; Neis, VB; Rodrigues, ALS, 2016) |
| "Agmatine is an endogenous polyamine produced from l-arginine and degraded by agmatinase (AGMAT)." | 1.91 | The expression of agmatinase manipulates the affective state of rats subjected to chronic restraint stress. ( Bai, S; Cai, X; Cheng, Y; He, Z; Tong, Z; Wang, G; Wang, T; Wu, J; Xu, C; Xue, Z; Yan, S; Yang, M; Zhang, H, 2023) |
| "Agmatine levels were significantly reduced in the hippocampus of T2DM rats as compared to the normal fed (NF) control animals." | 1.56 | Agmatine modulates anxiety and depression-like behaviour in diabetic insulin-resistant rats. ( Aglawe, MM; Kale, M; Kotagale, N; Nimje, N; Taksande, B; Umekar, M, 2020) |
| "Depression is one of the most common psychiatric symptoms in Alzheimer's disease (AD), and several studies have shown that oxidative stress plays a key role in the etiopathology of both AD and depression." | 1.48 | Agmatine attenuates depressive-like behavior and hippocampal oxidative stress following amyloid β (Aβ1-40) administration in mice. ( de Souza, V; Farina, M; Gonçalves, CL; Guerra de Souza, AC; Hartwig, JM; Prediger, RD, 2018) |
| "Agmatine is a neuromodulator that has been proposed as a therapeutic strategy for the treatment of major depressive disorder (MDD)." | 1.48 | Single administration of agmatine reverses the depressive-like behavior induced by corticosterone in mice: Comparison with ketamine and fluoxetine. ( Bettio, LB; Fraga, DB; Freitas, AE; Gonçalves, FM; Heinrich, IA; Leal, RB; Lopes, MW; Moretti, M; Neis, VB; Olescowicz, G; Rodrigues, ALS; Rosa, PB, 2018) |
| "Epilepsy is fourth most common neurological disorders associated with depression and cognitive deficits." | 1.46 | Agmatine for combined treatment of epilepsy, depression and cognitive impairment in chronic epileptic animals. ( Bagga, N; Gawande, DY; Goel, RK; Kaur, A; Kaur, N; Singh, T, 2017) |
| "Agmatine pre-treatment at 40mg/kg ameliorated LPS-induced neuroinflammation by attenuating brain IL-1β and TNF-α level." | 1.43 | Agmatine ameliorates lipopolysaccharide induced depressive-like behaviour in mice by targeting the underlying inflammatory and oxido-nitrosative mediators. ( Bulani, VD; Chowdhury, AA; Deshpande, PS; Gawali, NB; Juvekar, AR; Nagmoti, DM, 2016) |
| "Agmatine treatment also normalized the elevated corticosterone levels and prevented the body weight changes in chronically stressed animals." | 1.39 | Agmatine attenuates chronic unpredictable mild stress induced behavioral alteration in mice. ( Aglawe, MM; Dixit, MP; Faldu, DS; Kotagale, NR; Sakaria, JN; Taksande, BG; Umekar, MJ, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (33.33) | 29.6817 |
| 2010's | 14 (46.67) | 24.3611 |
| 2020's | 6 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yan, S | 1 |
| Xu, C | 1 |
| Yang, M | 1 |
| Zhang, H | 1 |
| Cheng, Y | 1 |
| Xue, Z | 1 |
| He, Z | 1 |
| Wang, T | 1 |
| Bai, S | 1 |
| Wang, G | 1 |
| Wu, J | 1 |
| Tong, Z | 1 |
| Cai, X | 1 |
| Vinchurney, MD | 1 |
| Dhokne, MD | 1 |
| Kotagale, N | 3 |
| Umekar, MJ | 4 |
| Taksande, B | 3 |
| Önel, T | 1 |
| Arıcıoğlu, F | 3 |
| Yıldırım, E | 1 |
| Zortul, H | 1 |
| Yaba, A | 1 |
| Sahin Ozkartal, C | 1 |
| Tuzun, E | 1 |
| Kucukali, CI | 1 |
| Ulusoy, C | 1 |
| Giris, M | 1 |
| Deshmukh, R | 1 |
| Dixit, M | 1 |
| Fating, R | 1 |
| Umekar, M | 2 |
| Kale, M | 1 |
| Nimje, N | 1 |
| Aglawe, MM | 3 |
| Singh, T | 1 |
| Bagga, N | 1 |
| Kaur, A | 1 |
| Kaur, N | 1 |
| Gawande, DY | 1 |
| Goel, RK | 1 |
| Guerra de Souza, AC | 1 |
| Gonçalves, CL | 1 |
| de Souza, V | 1 |
| Hartwig, JM | 1 |
| Farina, M | 2 |
| Prediger, RD | 1 |
| Neis, VB | 4 |
| Bettio, LB | 1 |
| Moretti, M | 2 |
| Rosa, PB | 2 |
| Olescowicz, G | 1 |
| Fraga, DB | 1 |
| Gonçalves, FM | 1 |
| Freitas, AE | 5 |
| Heinrich, IA | 1 |
| Lopes, MW | 1 |
| Leal, RB | 1 |
| Rodrigues, ALS | 3 |
| Weiss, T | 1 |
| Bernard, R | 1 |
| Bernstein, HG | 1 |
| Veh, RW | 1 |
| Laube, G | 1 |
| Akasaka, N | 1 |
| Fujiwara, S | 1 |
| Kotagale, NR | 4 |
| Paliwal, NP | 1 |
| Taksande, BG | 4 |
| Faldu, DS | 1 |
| Dixit, MP | 1 |
| Sakaria, JN | 1 |
| Bettio, LE | 1 |
| Santos, DB | 1 |
| Ribeiro, CM | 1 |
| Rodrigues, AL | 5 |
| Manosso, LM | 1 |
| Daufenbach, J | 1 |
| Chopde, CT | 2 |
| Egea, J | 1 |
| Buendia, I | 1 |
| Gómez-Rangel, V | 1 |
| Parada, E | 1 |
| Navarro, E | 1 |
| Casas, AI | 1 |
| Wojnicz, A | 1 |
| Ortiz, JA | 1 |
| Cuadrado, A | 1 |
| Ruiz-Nuño, A | 1 |
| Lopez, MG | 1 |
| Gawali, NB | 2 |
| Bulani, VD | 2 |
| Chowdhury, AA | 1 |
| Deshpande, PS | 2 |
| Nagmoti, DM | 1 |
| Juvekar, AR | 2 |
| Gursahani, MS | 1 |
| Kothavade, PS | 1 |
| Jiang, XZ | 1 |
| Li, YF | 2 |
| Zhang, YZ | 1 |
| Chen, HX | 1 |
| Li, J | 2 |
| Wang, NP | 1 |
| Tripathi, SJ | 1 |
| Ugale, RR | 1 |
| Gong, ZH | 1 |
| Cao, JB | 1 |
| Wang, HL | 1 |
| Luo, ZP | 1 |
| Halaris, A | 1 |
| Piletz, JE | 1 |
| Altunbas, H | 1 |
| Dias Elpo Zomkowski, A | 1 |
| Oscar Rosa, A | 1 |
| Lin, J | 2 |
| Santos, AR | 4 |
| Calixto, JB | 2 |
| Lúcia Severo Rodrigues, A | 1 |
| Zomkowski, AD | 3 |
| Krass, M | 1 |
| Wegener, G | 1 |
| Vasar, E | 1 |
| Volke, V | 1 |
| Hammes, L | 1 |
3 reviews available for agmatine and Depression
| Article | Year |
|---|---|
The therapeutic and nutraceutical potential of agmatine, and its enhanced production using Aspergillus oryzae.
Topics: Agmatine; Animals; Aspergillus oryzae; Depression; Dietary Supplements; Humans; Metabolic Diseases; | 2020 |
Agmatine, a potential novel therapeutic strategy for depression.
Topics: Agmatine; Animals; Antidepressive Agents; Depression; Depressive Disorder, Major; Humans; Neurotrans | 2016 |
Relevance of imidazoline receptors and agmatine to psychiatry: a decade of progress.
Topics: Agmatine; Blood Platelets; Brain; Depression; Humans; Imidazoline Receptors; Integrins; Nervous Syst | 2003 |
27 other studies available for agmatine and Depression
| Article | Year |
|---|---|
The expression of agmatinase manipulates the affective state of rats subjected to chronic restraint stress.
Topics: Agmatine; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Depression; Hippocampus; Hum | 2023 |
Agmatine prevents the manifestation of impulsive burying and depression-like behaviour in progesterone withdrawn female rats.
Topics: Agmatine; Animals; Calcium Carbonate; Depression; Female; Humans; Premenstrual Dysphoric Disorder; P | 2023 |
The effect of maternal separation stress-induced depression on ovarian reserve in Sprague Dawley Rats: The possible role of imipramine and agmatine through a mTOR signal pathway.
Topics: Agmatine; Animals; Depression; Female; Imipramine; Maternal Deprivation; Ovarian Reserve; Rats; Rats | 2023 |
Antidepressant-like effects of agmatine and NOS inhibitors in chronic unpredictable mild stress model of depression in rats: The involvement of NLRP inflammasomes.
Topics: Agmatine; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Inflammasomes; Male; N | 2019 |
Agmatine ameliorates manifestation of depression-like behavior and hippocampal neuroinflammation in mouse model of Alzheimer's disease.
Topics: Agmatine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Depression; Disease Models, Animal; Hip | 2020 |
Agmatine modulates anxiety and depression-like behaviour in diabetic insulin-resistant rats.
Topics: Agmatine; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal; Cytokines; | 2020 |
Agmatine for combined treatment of epilepsy, depression and cognitive impairment in chronic epileptic animals.
Topics: Agmatine; Animals; Cognitive Dysfunction; Depression; Epilepsy; Male; Mice; Pentylenetetrazole | 2017 |
Agmatine attenuates depressive-like behavior and hippocampal oxidative stress following amyloid β (Aβ1-40) administration in mice.
Topics: Agmatine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antidepressive Agents; Antioxidants; De | 2018 |
Single administration of agmatine reverses the depressive-like behavior induced by corticosterone in mice: Comparison with ketamine and fluoxetine.
Topics: Agmatine; Animals; Antidepressive Agents; Brain; Corticosterone; Depression; Disks Large Homolog 4 P | 2018 |
Agmatine modulates spontaneous activity in neurons of the rat medial habenular complex-a relevant mechanism in the pathophysiology and treatment of depression?
Topics: Action Potentials; Agmatine; Animals; Benzofurans; Depression; Female; Habenula; Humans; Idazoxan; I | 2018 |
Possible involvement of neuropeptide Y Y1 receptors in antidepressant like effect of agmatine in rats.
Topics: Agmatine; Animals; Antidepressive Agents; Arginine; Behavior, Animal; Depression; Dose-Response Rela | 2013 |
Agmatine attenuates chronic unpredictable mild stress induced behavioral alteration in mice.
Topics: Agmatine; Animals; Antidepressive Agents; Behavior, Animal; Body Weight; Corticosterone; Depression; | 2013 |
Agmatine abolishes restraint stress-induced depressive-like behavior and hippocampal antioxidant imbalance in mice.
Topics: Agmatine; Animals; Antidepressive Agents; Antioxidants; Depression; Female; Hippocampus; Immobility | 2014 |
Depressive-like behavior induced by tumor necrosis factor-α is abolished by agmatine administration.
Topics: Agmatine; Analysis of Variance; Animals; Antidepressive Agents; Depression; Disease Models, Animal; | 2014 |
Chronic agmatine treatment prevents behavioral manifestations of nicotine withdrawal in mice.
Topics: Agmatine; Animals; Anxiety; Behavior, Animal; Brain; Depression; Infusions, Intraventricular; Male; | 2015 |
Agmatine, by Improving Neuroplasticity Markers and Inducing Nrf2, Prevents Corticosterone-Induced Depressive-Like Behavior in Mice.
Topics: Agmatine; Anhedonia; Animals; Antidepressive Agents; Astrocytes; Behavior, Animal; Biomarkers; Corti | 2016 |
Agmatine ameliorates lipopolysaccharide induced depressive-like behaviour in mice by targeting the underlying inflammatory and oxido-nitrosative mediators.
Topics: Agmatine; Animals; Depression; Drug Delivery Systems; Inflammation Mediators; Lipopolysaccharides; M | 2016 |
Agmatine attenuates chronic unpredictable mild stress-induced anxiety, depression-like behaviours and cognitive impairment by modulating nitrergic signalling pathway.
Topics: Agmatine; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal; Chronic Di | 2017 |
[5-HT1A/1B receptors, alpha2-adrenoceptors and the post-receptor adenylate cyclase activation in the mice brain are involved in the antidepressant-like action of agmatine].
Topics: Adenylyl Cyclases; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Agmatine; Animals; Ant | 2008 |
Antidepressant like effect of selective serotonin reuptake inhibitors involve modulation of imidazoline receptors by agmatine.
Topics: Agmatine; Animals; Antidepressive Agents; Arginine; Brain; Carboxy-Lyases; Depression; Dose-Response | 2009 |
Antidepressant-like effect of agmatine and its possible mechanism.
Topics: Agmatine; Animals; Antidepressive Agents; Biogenic Monoamines; Depression; Dose-Response Relationshi | 2003 |
Is agmatine an endogenous anxiolytic/antidepressant agent?
Topics: Agmatine; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal; Depression | 2003 |
Evidence for serotonin receptor subtypes involvement in agmatine antidepressant like-effect in the mouse forced swimming test.
Topics: Agmatine; Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Depression; Diseas | 2004 |
Evidence for the involvement of the opioid system in the agmatine antidepressant-like effect in the forced swimming test.
Topics: Agmatine; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Female; Male; Mice; Mo | 2005 |
Putrescine produces antidepressant-like effects in the forced swimming test and in the tail suspension test in mice.
Topics: Agmatine; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Female; Imipramine; Im | 2006 |
Antidepressant-like effect of agmatine is not mediated by serotonin.
Topics: Agmatine; Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Depression; Diseas | 2008 |
Agmatine produces antidepressant-like effects in two models of depression in mice.
Topics: Agmatine; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Depression; Disease Mode | 2002 |