agar and Waldenstrom-Macroglobulinemia

Topics: Agar; Aged; Alkylating Agents; Anemia, Hemolytic; Blood Coagulation Disorders; Blood Protein Disorders; Blood Viscosity; Chlorambucil; Clinical Trials as Topic; Electrophoresis; Female; gamma-Globulins; Hemolysis; Humans; Immunoelectrophoresis; Immunoglobulin G; Immunoglobulin M; Male; Middle Aged; Multiple Myeloma; Prednisone; Waldenstrom Macroglobulinemia

Topics: Agar; Animals; Blood Protein Electrophoresis; Electrophoresis; Humans; Immunoelectrophoresis; Immunoglobulin M; Liver Cirrhosis; Molecular Weight; Osmosis; Polysaccharides; Rabbits; Waldenstrom Macroglobulinemia

Topics: Acetates; Adult; Agar; Age Factors; Aged; Alpha-Globulins; Beta-Globulins; Blood Protein Disorders; Blood Protein Electrophoresis; Cellulose; Electrophoresis; Electrophoresis, Paper; gamma-Globulins; Gels; Humans; Middle Aged; Multiple Myeloma; Plasmacytoma; Waldenstrom Macroglobulinemia

The frequency of M-components was studied by agar gel electrophoresis in sera from 807 patients, 467 (57%) females and 340 (43%) males with histologically proven solid malignant neoplasms.M-components were found in the sera of 40 male and 20 female patients. Apart from two known cases of multiple myeloma and one case of Waldenström's macroglobulinaemia, none of the patients were found to be suffering from these diseases. The frequency of M-components increased with age, and this was more evident in males. Twenty-two of 60 patients with M-components did not exhibit abnormalities on immunoelectrophoresis. Of the 35 remaining patients, 27 had an abnormal component of the IgG class, 6 of the IgA and 2 of the IgM class. M-components were found in the sera of patients with a wide variety of neoplasms. There appeared to be no evidence of an increased frequency of M-components in the sera of patients with solid malignant neoplasms compared with normal adult population.

Topics: Adolescent; Adult; Agar; Aged; Child; Electrophoresis; Female; Gastrointestinal Neoplasms; Genital Neoplasms, Female; Humans; Immunoelectrophoresis; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Immunoglobulins; Lung Neoplasms; Male; Middle Aged; Multiple Myeloma; Neoplasms; Urinary Bladder Neoplasms; Waldenstrom Macroglobulinemia

Topics: Agar; Amino Acid Sequence; Antibody-Producing Cells; Bence Jones Protein; Centrifugation, Density Gradient; Chromatography, Gel; Clone Cells; Electrophoresis; Epitopes; Humans; Immunodiffusion; Immunoelectrophoresis; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Immunoglobulins; Peptide Chain Termination, Translational; Waldenstrom Macroglobulinemia

Topics: Agar; Aged; Bence Jones Protein; Blood Protein Disorders; Blood Protein Electrophoresis; Female; Humans; Immunodiffusion; Immunoelectrophoresis; Immunoglobulin Fragments; Immunoglobulin G; Immunoglobulin Heavy Chains; Immunoglobulin kappa-Chains; Immunoglobulin lambda-Chains; Immunoglobulin M; Plasmacytoma; Ultracentrifugation; Waldenstrom Macroglobulinemia

Topics: Acrylamides; Agar; Animals; Chromatography, Gel; Humans; Immune Sera; Immunodiffusion; Immunoglobulin Fragments; Immunoglobulin G; Immunoglobulin M; Protein Conformation; Rabbits; Waldenstrom Macroglobulinemia

Topics: Absorption; Agar; Antigens; Bence Jones Protein; Blood Protein Electrophoresis; Chromatography, Gel; Chromatography, Ion Exchange; gamma-Globulins; Immune Sera; Immunodiffusion; Immunoglobulins; Macroglobulins; Multiple Myeloma; Neoplasm Proteins; Serum Albumin; Waldenstrom Macroglobulinemia

Topics: Agar; Animals; Antigen-Antibody Reactions; Antigens; Binding Sites; Dinitrophenols; Enterobacteriaceae; Epitopes; Hemocyanins; Humans; Immune Sera; Immunochemistry; Immunodiffusion; Immunoelectrophoresis; Immunoglobulin M; Klebsiella; Papain; Polysaccharides, Bacterial; Precipitin Tests; Rabbits; Trypsin; Ultracentrifugation; Waldenstrom Macroglobulinemia

Topics: Agar; Animals; Antibodies; Arthritis, Rheumatoid; Cellulose; Chromatography; Complement System Proteins; Erythrocytes; Gels; Hemolysin Proteins; Hemolysis; Hemolytic Plaque Technique; Humans; Immune Sera; Immunodiffusion; Immunoglobulin G; Immunoglobulin M; Mercaptoethanol; Rabbits; Rheumatoid Factor; Sheep; Waldenstrom Macroglobulinemia

Topics: Agar; Aged; Electrophoresis; Gels; Humans; Immunoelectrophoresis; Lymphoma, Non-Hodgkin; Male; Nephrotic Syndrome; Pelvic Neoplasms; Waldenstrom Macroglobulinemia

Topics: Agar; Animals; gamma-Globulins; Goats; Humans; Immune Sera; Immunoelectrophoresis; Liver Cirrhosis; Polysaccharides; Rabbits; Transferrin; Waldenstrom Macroglobulinemia

Topics: Agammaglobulinemia; Agar; Antibodies; Bence Jones Protein; Equipment and Supplies; gamma-Globulins; Humans; Immunodiffusion; Immunoglobulin G; Immunoglobulins; Precipitin Tests; Research; Waldenstrom Macroglobulinemia

Topics: Agar; Electrophoresis; Glycoproteins; Humans; Immunoelectrophoresis; In Vitro Techniques; Macroglobulins; Multiple Myeloma; Neoplasm Proteins; Waldenstrom Macroglobulinemia

Topics: Agar; Animals; Chromatography; Chromatography, Gel; Humans; Immunodiffusion; Immunoelectrophoresis; Lipoproteins; Macroglobulins; Rabbits; Research; Rheumatoid Factor; Serum Globulins; Waldenstrom Macroglobulinemia

Topics: Agar; Animals; Blood; Immunoelectrophoresis; Multiple Myeloma; Polysaccharides; Precipitin Tests; Rabbits; Sepharose; Waldenstrom Macroglobulinemia

Topics: Agar; Globulins; Humans; Serum Globulins; Waldenstrom Macroglobulinemia

Topics: Agar; Blood Proteins; Cryoglobulinemia; Multiple Myeloma; Plasma Cells; Serum Globulins; Waldenstrom Macroglobulinemia