agar and Hyperthermia

Swarming motility is a virulence factor for. Thirty-one. The median MPT value was determined as 44 °C. In the disk diffusion assay, susceptibility development was observed in 94% of isolates for at least one antibiotic. In the time-kill assay, we observed a significant killing effect of hyperthermia in combination with meropenem. Under the microscope, we observed the formation of spherical cells by the effect of heat.. We conclude that these findings might be useful when employing the hyperthermia method to treat infectious diseases caused by

Topics: Agar; Anti-Bacterial Agents; Humans; Hyperthermia; Proteus mirabilis

Magnetic nanoparticles have recently been the subject of intensive research for biomedical applications. In particular, injecting colloidal magnetic nanoparticles into the cancerous tissues and heating them by heat dissipation from magnetic nanoparticles with applying an alternating magnetic field have been expected as a new cancer treatment (magnetic fluid hyperthermia). In this study, iron oxide nanoparticles were dispersed in an agar phantom in order to use them to mimic tumor tissue that is surrounded by normal tissue. Their heat transfer properties were investigated to study magnetic fluid hyperthermia. Magnetite nanoparticles with a median diameter of 13.8 nm fixed in an agar matrix showed a specific absorption rate of 5.6 W/g in a field of 5.0 kA/m, and a concentration of 5 wt.% was sufficient to increase the temperature above the temperature required for magnetic hyperthermia treatment. The simulated temperature profile inside the phantom shows reasonable agreement with the temperature distribution obtained by experiments. These results offer a guide for preventing the overheating of normal tissues during hyperthermia treatment.

Topics: Agar; Hot Temperature; Humans; Hyperthermia; Hyperthermia, Induced; Magnetic Iron Oxide Nanoparticles; Magnetite Nanoparticles