agar has been researched along with Hepatitis* in 14 studies
14 other study(ies) available for agar and Hepatitis
Article | Year |
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Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation.
The central role of T cell activation in hepatocellular injury has been well documented. In this article, we provide evidence suggesting that T cells may also play a protective role in liver disease by releasing interleukin-22 (IL-22), a recently identified T cell-derived cytokine whose biological significance is unclear. IL-22 messenger RNA and protein expression are significantly elevated in T cell-mediated hepatitis induced by concanavalin A (ConA) but are less extensively elevated in the carbon tetrachloride-induced liver injury model. Activated CD3(+) T cells are likely responsible for the production of IL-22 in the liver after injection of ConA. The IL-22 receptor is normally expressed at high levels by hepatocytes and further induced after ConA injection. IL-22 blockade with a neutralizing antibody reduces signal transducer and activator of transcription factor 3 (STAT3) activation and worsens liver injury in T cell-mediated hepatitis, whereas injection of recombinant IL-22 attenuates such injury. In vitro treatment with recombinant IL-22 or overexpression of IL-22 promotes cell growth and survival in human hepatocellular carcinoma HepG2 cells. Stable overexpression of IL-22 in HepG2 cells constitutively activates STAT3 and induces expression of a variety of antiapoptotic (e.g., Bcl-2, Bcl-xL, Mcl-1) and mitogenic (e.g., c-myc, cyclin D1, Rb2, CDK4) proteins. Blocking STAT3 activation abolishes the antiapoptotic and mitogenic actions of IL-22 in hepatic cells. In conclusion, the T cell-derived cytokine IL-22 is a survival factor for hepatocytes; this suggests that T cell activation may also prevent and repair liver injury by releasing hepatoprotective cytokine IL-22 in addition to its previously documented central role in hepatocellular injury. Topics: Agar; Animals; Carcinoma, Hepatocellular; Cell Division; Cell Line, Tumor; Cell Survival; Chemical and Drug Induced Liver Injury; Concanavalin A; DNA-Binding Proteins; Hepatitis; Hepatocytes; Humans; Interleukin-22; Interleukins; Liver Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Receptors, Interleukin; STAT3 Transcription Factor; T-Lymphocytes; Trans-Activators | 2004 |
[Changes of the coefficient of lactate dehydrogenase LDG5-LDG4 isoenzymes in liver diseases].
Topics: Agar; Chemical and Drug Induced Liver Injury; Colorimetry; Electrophoresis; Hepatitis; Hepatitis A; Humans; Isoenzymes; L-Lactate Dehydrogenase | 1974 |
Association between C'3 phenotypes and various diseases.
Topics: Agar; Alleles; Arthritis, Rheumatoid; Diabetes Mellitus; Electrophoresis; Gels; Hepatitis; Humans; Hyperlipidemias; Leprosy; Phenotype; Polymorphism, Genetic; Serologic Tests | 1972 |
[Agar-electrophoretic protein determination in liver homogenates].
Topics: Agar; Animals; Biopsy; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Electrophoresis; Gels; Hepatitis; Histocytochemistry; Humans; Liver Cirrhosis; Liver Diseases; Proteins; Rabbits; Rats; Thioacetamide | 1972 |
Change of serum -glutamyl transpeptidase level and isoenzyme pattern in hepatobiliary pancreatic disease.
Topics: Acyltransferases; Agar; Bile Duct Neoplasms; Biliary Tract Diseases; Cholelithiasis; Electrophoresis; Glutamates; Hepatitis; Humans; Isoenzymes; Jaundice; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Pancreatic Diseases; Pancreatic Neoplasms; Pancreatitis | 1972 |
Sensitive matrix gel diffusion test for the detection of Australia antigen.
A matrix gel diffusion (MGD) procedure with a sensitivity comparable to the complement fixation test (CF) has been developed for detecting Australia antigen in serum. The test utilizes a thin layer of agar (0.1 mm) with an applied plastic matrix. Reactants are introduced directly onto the surface of the agar through wells in the plastic matrix. End points obtained by CF with a panel of 11 sera varied from 1:8 to 1:512. When these sera were tested by MGD, end points for detection of antigen were within one dilution of that obtained by CF. Topics: Agar; Animals; Complement Fixation Tests; Erythrocytes; Haplorhini; Hepatitis; Hepatitis B virus; Hepatitis, Animal; Humans; Immune Sera; Immunodiffusion; Methods; Plastics; Sheep; Staining and Labeling; Tannins; Thiazines | 1971 |
[Arylamidase and its isoenzymes in diseases of the pancreas and liver].
Topics: Acute Disease; Agar; Alanine; Alkaline Phosphatase; Amides; Aminohydrolases; Anilides; Cholestasis; Chronic Disease; Electrophoresis; Hepatitis; Humans; Isoenzymes; Leucine; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Naphthalenes; Nitro Compounds; Pancreatic Diseases; Pancreatitis | 1971 |
[Lipoproteid electrophoresis in agarose gel].
Topics: Agar; Cellulose; Cholestasis; Diabetes Mellitus; Electrophoresis; Follow-Up Studies; Gels; Hepatitis; Humans; Lipoproteins; Liver Cirrhosis; Medical Records; Methods; Nephrosis | 1971 |
[Quantitative immunoglobulin determination in liver diseases].
Topics: Agar; Alcoholism; Diabetes Complications; Fatty Liver; gamma-Globulins; Hepatitis; Humans; Immunodiffusion; Immunoglobulin G; Immunoglobulin M; Liver Cirrhosis; Liver Diseases; Liver Function Tests; Methods; Time Factors | 1970 |
The detection of Australia antigen and anti-Au antibodies by a rapid procedure combining electrophoresis and immunoprecipitation.
Topics: Agar; Antibodies; Antibody Formation; Blood Transfusion; Electrophoresis; Hemophilia A; Hepatitis; Hepatitis B Antigens; Hepatitis B virus; Humans; Immune Sera; Methods; Precipitin Tests; Thalassemia | 1969 |
[Immunological studies on the serum of cases of hepatitis and liver tissue by means of an agar diffusion method].
Topics: Agar; Antigen-Antibody Reactions; Hepatitis; Hepatitis A; Immune Sera; Liver Diseases | 1963 |
[APROPOS OF THE IMMUNODIAGNOSIS OF EPIDEMIC HEPATITIS. 1. USE OF THE AGAR PRECIPITATION REACTION FOR DIAGNOSIS].
Topics: Agar; Antigen-Antibody Reactions; Clinical Laboratory Techniques; Communicable Diseases; Hepatitis; Hepatitis A; Humans; Immunologic Tests | 1963 |
[APROPOS OF THE IMMUNODIAGNOSIS OF EPIDEMIC HEPATITIS. 2. COMPARATIVE STUDY OF THE AGAR PRECIPITATION REACTION, HETEROHEMAGGLUTINATION REACTION AND BILIRUBINEMIA LEVEL IN EPIDEMIC HEPATITIS].
Topics: Agar; Antigen-Antibody Reactions; Bilirubin; Blood Chemical Analysis; Communicable Diseases; Hemagglutination; Hepatitis; Hepatitis A; Humans; Hyperbilirubinemia; Immunologic Tests | 1963 |
[On increased beta-lipoproteins following epidemic hepatitis. 3. Determination of beta-lipoproteins with K-agar].
Topics: Agar; Epidemics; Hepatitis; Hepatitis A; Humans; Lipoproteins; Lipoproteins, LDL | 1961 |