agar and Edema

We have previously reported that agaro-oligosaccharides (AGOs) suppressed the elevated levels of nitric oxide (NO), prostaglandin E₂(PGE₂), and pro-inflammatory cytokines in activated monocytes/macrophages, via heme oxygenase-1 induction. In this report, we initially demonstrated that AGOs intake inhibited NO production in activated peritoneal macrophages. Then, we tested for the ability of AGOs to prevent tumor promotion on the two-stage mouse skin carcinogenesis model. As a result, AGOs feeding led to delayed tumor appearance and decreased tumor number. It is known that PGE₂ is one of key players in carcinogenesis. Thus, we confirmed that PGE₂ production was suppressed by AGOs intake in TPA-induced ear edema model. We also demonstrated that cyclooxygenase-2 and microsomal PGE synthase-1, rate-limiting enzymes in PGE₂ production, were down-regulated by AGOs in human monocytes. Consequently, AGOs are expected to prevent tumor promotion by inhibiting PGE₂ elevation in chronic inflammation site.

Topics: 9,10-Dimethyl-1,2-benzanthracene; Agar; Animals; Antineoplastic Agents; Carcinogens; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Edema; Humans; Intramolecular Oxidoreductases; Leukocytes, Mononuclear; Macrophages, Peritoneal; Male; Mice; Mice, Inbred ICR; Nitric Oxide; Nitrites; Oligosaccharides; Prostaglandin-E Synthases; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate

Frost sutures are temporary suspension sutures conventionally used in oculoplastics. The case is presented here of a patient with multiple orbital fractures who developed worsening conjunctival chemosis and pseudoproptosis. This patient was managed successfully with Frost sutures. To the best of the authors' knowledge, there is no documented use of Frost sutures in this type of case. It is emphasized that this technique should only be considered following rigorous exclusion of retrobulbar pathology and careful attention towards early detection of raised intraocular pressure.

Topics: Acrylamides; Adult; Agar; Bandages; Conjunctival Diseases; Edema; Exophthalmos; Eyelids; Gels; Humans; Male; Orbital Fractures; Suture Techniques; Sutures; Wound Healing

Topics: Agar; Animals; Animals, Newborn; Carpal Bones; Cattle; Cattle Diseases; Edema; Fibrin; Histological Techniques; Inflammation; Injections, Intra-Articular; Joints; Mycoplasma; Mycoplasma mycoides; Radius; Synovial Fluid; Synovitis; Tarsal Joints; Time Factors

Topics: Academic Dissertations as Topic; Agar; Animals; Argon; Blood; Blood Proteins; Choroid; Coloring Agents; Edema; Epithelium; Eye Diseases; Fluoresceins; Fundus Oculi; Krypton; Laser Therapy; Lasers; Methods; Ophthalmoscopy; Optics and Photonics; Photoreceptor Cells; Rabbits; Radiation Injuries, Experimental; Retina; Retinal Pigments; Spectrophotometry

Topics: Agar; Animals; Anti-Inflammatory Agents; Capillary Permeability; Carrageenan; Dextrans; Edema; Formaldehyde; Granuloma; Histamine; Kaolin; Mice; Phenylbutazone; Rats; Serotonin

Topics: Agar; Animals; Dextrans; Edema; Histamine Release; Rats; Sulfonic Acids; Vasomotor System