ag-879 has been researched along with Glioma* in 1 studies
1 other study(ies) available for ag-879 and Glioma
Article | Year |
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delta-Opioid receptors stimulate ERK1/2 activity in NG108-15 hybrid cells by integrin-mediated transactivation of TrkA receptors.
This study demonstrates that activation of delta-opioid receptors (DORs) in neuroblastomaxglioma (NG108-15) hybrid cells by [D-Ala2, D-Leu5]enkephalin (DADLE) and etorphine significantly enhances cell adhesion to fibronectin-coated wells. This effect is blocked by both naloxone and integrin binding RGDT peptides. In addition, cell adhesion turned out to be a prerequisite for DOR-stimulated transactivation of Tropomyosin-related kinase A (TrkA) and extracellular signal-regulated kinases 1/2 (ERK1/2). Because inhibition of TrkA activation by AG879 completely blocked DOR- and integrin-mediated ERK1/2 signaling, the present results indicate that in NG108-15 cells DOR-stimulated ERK1/2 activation is mediated by integrin-induced transactivation of TrkA. Topics: Cell Adhesion; Enkephalin, Leucine-2-Alanine; Etorphine; Glioma; Humans; Hybrid Cells; Integrins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Naloxone; Neuroblastoma; Neurons; Oligopeptides; Protein Kinase Inhibitors; Receptor, trkA; Receptors, Opioid, delta; Transcriptional Activation; Tyrphostins | 2008 |