ag-213 has been researched along with Hepatitis--Viral--Animal* in 1 studies
1 other study(ies) available for ag-213 and Hepatitis--Viral--Animal
| Article | Year |
|---|---|
Induction of macrophage procoagulant activity by murine hepatitis virus strain 3: role of tyrosine phosphorylation.
The induction of a unique macrophage procoagulant molecule by murine hepatitis virus strain 3 correlates with the severity of viral hepatitis. The role of tyrosine phosphorylation in the signalling pathway leading to procoagulant expression was studied. Murine hepatitis virus strain 3 initiated a rapid increase in phosphotyrosine accumulation. Tyrosine kinase inhibition precluded this increase and abrogated expression of the virus-induced procoagulant mouse fibrinogen-like protein (musfiblp) gene. These findings suggest that manipulation of this signalling pathway in vivo might represent a novel approach to treating this disease. Topics: Animals; Benzoquinones; Catechols; Cells, Cultured; Female; Genistein; Hepatitis, Viral, Animal; Isoflavones; Kinetics; Lactams, Macrocyclic; Macrophages, Peritoneal; Mice; Murine hepatitis virus; Nitriles; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tyrosine; Tyrphostins | 1995 |