ag 1879 has been researched along with Scleroderma, Systemic in 1 studies
3-(4-chlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazolo(3,4-d)pyrimidin-4-amine: Fyn kinase inhibitor
Scleroderma, Systemic: A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fibrotic diseases such as SSc (systemic sclerosis, scleroderma) are characterized by the abnormal presence of the myofibroblast, a specialized type of fibroblast that overexpresses the highly contractile protein α-smooth muscle actin." | 1.38 | Focal adhesion kinase and reactive oxygen species contribute to the persistent fibrotic phenotype of lesional scleroderma fibroblasts. ( Abraham, DJ; Baron, M; Denton, CP; Khan, K; Leask, A; Liu, S; Murphy-Marshman, H; Shi-wen, X; Thompson, K, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shi-wen, X | 1 |
| Thompson, K | 1 |
| Khan, K | 1 |
| Liu, S | 1 |
| Murphy-Marshman, H | 1 |
| Baron, M | 1 |
| Denton, CP | 1 |
| Leask, A | 1 |
| Abraham, DJ | 1 |
1 other study available for ag 1879 and Scleroderma, Systemic
| Article | Year |
|---|---|
Focal adhesion kinase and reactive oxygen species contribute to the persistent fibrotic phenotype of lesional scleroderma fibroblasts.
Topics: Animals; Cells, Cultured; Female; Focal Adhesion Protein-Tyrosine Kinases; Humans; Male; Mice; Myofi | 2012 |