ag 1879 has been researched along with Pancreatic Neoplasms in 7 studies
3-(4-chlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazolo(3,4-d)pyrimidin-4-amine: Fyn kinase inhibitor
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "We tested the hypotheses that Src tyrosine kinase overactivity represents a chemoresistance mechanism and that Src inhibition may enhance gemcitabine cytotoxicity in pancreatic adenocarcinoma cells." | 7.72 | Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells. ( Ashley, SW; Duxbury, MS; Ito, H; Whang, EE; Zinner, MJ, 2004) |
| "We tested the hypotheses that Src tyrosine kinase overactivity represents a chemoresistance mechanism and that Src inhibition may enhance gemcitabine cytotoxicity in pancreatic adenocarcinoma cells." | 3.72 | Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells. ( Ashley, SW; Duxbury, MS; Ito, H; Whang, EE; Zinner, MJ, 2004) |
| "Knockdown of the SFKs in pancreatic cancer cells was achieved by transfecting small interfering RNAs, and its effects were investigated using proliferation, wound, and invasion assays." | 1.40 | The inhibition of SRC family kinase suppresses pancreatic cancer cell proliferation, migration, and invasion. ( Cho, Y; Je, DW; Ji, YG; Lee, DH; O, YM, 2014) |
| "In two human pancreatic cancer cell lines, PK-9 and MIA PaCa-2, we found that a selective Src protein tyrosine kinase inhibitor, PP2, inhibited gemcitabine-induced cell growth suppression." | 1.35 | Inhibition of Src reduces gemcitabine-induced cytotoxicity in human pancreatic cancer cell lines. ( Ichihara, N; Kitanaka, A; Kubota, Y; Taminato, T; Tanaka, T, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Li, Z | 1 |
| Xie, X | 1 |
| Tan, G | 1 |
| Xie, F | 1 |
| Liu, N | 1 |
| Li, W | 1 |
| Sun, X | 1 |
| Je, DW | 1 |
| O, YM | 1 |
| Ji, YG | 1 |
| Cho, Y | 1 |
| Lee, DH | 1 |
| Ischenko, I | 1 |
| Camaj, P | 1 |
| Seeliger, H | 1 |
| Kleespies, A | 1 |
| Guba, M | 1 |
| De Toni, EN | 1 |
| Schwarz, B | 1 |
| Graeb, C | 1 |
| Eichhorn, ME | 1 |
| Jauch, KW | 1 |
| Bruns, CJ | 1 |
| Ma, YC | 1 |
| Shi, C | 1 |
| Zhang, YN | 1 |
| Wang, LG | 1 |
| Liu, H | 1 |
| Jia, HT | 1 |
| Zhang, YX | 1 |
| Sarkar, FH | 1 |
| Wang, ZS | 1 |
| Duxbury, MS | 1 |
| Ito, H | 1 |
| Zinner, MJ | 1 |
| Ashley, SW | 1 |
| Whang, EE | 1 |
| Di Florio, A | 1 |
| Capurso, G | 1 |
| Milione, M | 1 |
| Panzuto, F | 1 |
| Geremia, R | 1 |
| Delle Fave, G | 1 |
| Sette, C | 1 |
| Ichihara, N | 1 |
| Kubota, Y | 1 |
| Kitanaka, A | 1 |
| Tanaka, T | 1 |
| Taminato, T | 1 |
7 other studies available for ag 1879 and Pancreatic Neoplasms
| Article | Year |
|---|---|
Disulfiram Synergizes with SRC Inhibitors to Suppress the Growth of Pancreatic Ductal Adenocarcinoma Cells in Vitro and in Vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Pancreatic Ductal; Cell Line, Tu | 2021 |
The inhibition of SRC family kinase suppresses pancreatic cancer cell proliferation, migration, and invasion.
Topics: Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Humans; Neoplasm | 2014 |
Inhibition of Src tyrosine kinase reverts chemoresistance toward 5-fluorouracil in human pancreatic carcinoma cells: an involvement of epidermal growth factor receptor signaling.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Cell Line, Tu | 2008 |
The tyrosine kinase c-Src directly mediates growth factor-induced Notch-1 and Furin interaction and Notch-1 activation in pancreatic cancer cells.
Topics: Animals; Becaplermin; Blotting, Western; Cell Line, Tumor; Female; Furin; HeLa Cells; Humans; Interc | 2012 |
Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Blotting | 2004 |
Src family kinase activity regulates adhesion, spreading and migration of pancreatic endocrine tumour cells.
Topics: Adult; Aged; Cell Adhesion; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; | 2007 |
Inhibition of Src reduces gemcitabine-induced cytotoxicity in human pancreatic cancer cell lines.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Lin | 2008 |