ag 1879 has been researched along with Osteosarcoma in 3 studies
3-(4-chlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazolo(3,4-d)pyrimidin-4-amine: Fyn kinase inhibitor
Osteosarcoma: A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We show that the treatment of human osteosarcoma cell lines with a new pyrazolo[3,4-d]pyrimidine derivative Src inhibitor, namely SI-83, impaired cell viability, with a half-maximal inhibitory concentration of 12 microM in nonstarved cells and a kinetic different from that known for the Src inhibitor PP2." | 1.35 | Antiproliferative and proapoptotic activities of new pyrazolo[3,4-d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells. ( Angelucci, A; Bernardini, G; Bologna, M; Botta, M; Collodel, G; Di Stefano, A; Magrini, D; Manetti, F; Orlandini, M; Santucci, A; Schenone, S; Serchi, T; Spreafico, A; Tintori, C, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Manetti, F | 2 |
| Santucci, A | 2 |
| Locatelli, GA | 1 |
| Maga, G | 1 |
| Spreafico, A | 2 |
| Serchi, T | 2 |
| Orlandini, M | 2 |
| Bernardini, G | 2 |
| Caradonna, NP | 1 |
| Spallarossa, A | 1 |
| Brullo, C | 1 |
| Schenone, S | 2 |
| Bruno, O | 1 |
| Ranise, A | 1 |
| Bondavalli, F | 1 |
| Hoffmann, O | 1 |
| Bologna, M | 2 |
| Angelucci, A | 2 |
| Botta, M | 2 |
| Enomoto, M | 1 |
| Hayakawa, S | 1 |
| Itsukushima, S | 1 |
| Ren, DY | 1 |
| Matsuo, M | 1 |
| Tamada, K | 1 |
| Oneyama, C | 1 |
| Okada, M | 1 |
| Takumi, T | 1 |
| Nishita, M | 1 |
| Minami, Y | 1 |
| Magrini, D | 1 |
| Collodel, G | 1 |
| Di Stefano, A | 1 |
| Tintori, C | 1 |
3 other studies available for ag 1879 and Osteosarcoma
| Article | Year |
|---|---|
Identification of a novel pyrazolo[3,4-d]pyrimidine able to inhibit cell proliferation of a human osteogenic sarcoma in vitro and in a xenograft model in mice.
Topics: Animals; Bone Neoplasms; Bone Resorption; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Dru | 2007 |
Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signaling.
Topics: Cell Line, Tumor; Cell Movement; CSK Tyrosine-Protein Kinase; Enzyme Activation; Extracellular Matri | 2009 |
Antiproliferative and proapoptotic activities of new pyrazolo[3,4-d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; Male; Mice; Middle | 2008 |