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ag 1879 and Neoplasm Metastasis

ag 1879 has been researched along with Neoplasm Metastasis in 4 studies

3-(4-chlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazolo(3,4-d)pyrimidin-4-amine: Fyn kinase inhibitor

Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.

Research Excerpts

ExcerptRelevanceReference
"We tested the hypotheses that Src tyrosine kinase overactivity represents a chemoresistance mechanism and that Src inhibition may enhance gemcitabine cytotoxicity in pancreatic adenocarcinoma cells."7.72Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells. ( Ashley, SW; Duxbury, MS; Ito, H; Whang, EE; Zinner, MJ, 2004)
"We tested the hypotheses that Src tyrosine kinase overactivity represents a chemoresistance mechanism and that Src inhibition may enhance gemcitabine cytotoxicity in pancreatic adenocarcinoma cells."3.72Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells. ( Ashley, SW; Duxbury, MS; Ito, H; Whang, EE; Zinner, MJ, 2004)
"Although ErbB2 is known to enhance breast cancer metastasis, the signaling events responsible for this remain elusive."1.33Upregulation and activation of PKC alpha by ErbB2 through Src promotes breast cancer cell invasion that can be blocked by combined treatment with PKC alpha and Src inhibitors. ( Li, P; Sun, M; Tan, M; Yin, G; Yu, D, 2006)
"KM12L4A human metastatic colon cancer cells were stably transfected with two distinct kinase-defective mutants of c-src."1.32Expression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-xL and increases oxaliplatin- and Fas-induced apoptosis. ( Brunton, VG; Cawthorne, C; Dive, C; Frame, MC; Greaves, M; Griffiths, GJ; Koh, MY; Ottley, CJ; Pearson, DG; Reeves, NA; Tilby, MJ; Workman, P, 2004)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (75.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Liu, X1
Feng, R1
Duxbury, MS1
Ito, H1
Zinner, MJ1
Ashley, SW1
Whang, EE1
Griffiths, GJ1
Koh, MY1
Brunton, VG1
Cawthorne, C1
Reeves, NA1
Greaves, M1
Tilby, MJ1
Pearson, DG1
Ottley, CJ1
Workman, P1
Frame, MC1
Dive, C1
Tan, M1
Li, P1
Sun, M1
Yin, G1
Yu, D1

Other Studies

4 other studies available for ag 1879 and Neoplasm Metastasis

ArticleYear
Inhibition of epithelial to mesenchymal transition in metastatic breast carcinoma cells by c-Src suppression.
    Acta biochimica et biophysica Sinica, 2010, Volume: 42, Issue:7

    Topics: Biomarkers, Tumor; Blotting, Western; Breast Neoplasms; Cadherins; Cell Line; Cell Line, Tumor; Cell

2010
Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Apr-01, Volume: 10, Issue:7

    Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Blotting

2004
Expression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-xL and increases oxaliplatin- and Fas-induced apoptosis.
    The Journal of biological chemistry, 2004, Oct-29, Volume: 279, Issue:44

    Topics: Apoptosis; bcl-X Protein; Caspase 8; Caspases; Cell Line, Tumor; Colonic Neoplasms; CSK Tyrosine-Pro

2004
Upregulation and activation of PKC alpha by ErbB2 through Src promotes breast cancer cell invasion that can be blocked by combined treatment with PKC alpha and Src inhibitors.
    Oncogene, 2006, Jun-01, Volume: 25, Issue:23

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carbazoles; Cell Line, Tumor; Enzy

2006