ag 1879 has been researched along with Metastase in 4 studies
3-(4-chlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazolo(3,4-d)pyrimidin-4-amine: Fyn kinase inhibitor
| Excerpt | Relevance | Reference |
|---|---|---|
| "We tested the hypotheses that Src tyrosine kinase overactivity represents a chemoresistance mechanism and that Src inhibition may enhance gemcitabine cytotoxicity in pancreatic adenocarcinoma cells." | 7.72 | Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells. ( Ashley, SW; Duxbury, MS; Ito, H; Whang, EE; Zinner, MJ, 2004) |
| "We tested the hypotheses that Src tyrosine kinase overactivity represents a chemoresistance mechanism and that Src inhibition may enhance gemcitabine cytotoxicity in pancreatic adenocarcinoma cells." | 3.72 | Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells. ( Ashley, SW; Duxbury, MS; Ito, H; Whang, EE; Zinner, MJ, 2004) |
| "Although ErbB2 is known to enhance breast cancer metastasis, the signaling events responsible for this remain elusive." | 1.33 | Upregulation and activation of PKC alpha by ErbB2 through Src promotes breast cancer cell invasion that can be blocked by combined treatment with PKC alpha and Src inhibitors. ( Li, P; Sun, M; Tan, M; Yin, G; Yu, D, 2006) |
| "KM12L4A human metastatic colon cancer cells were stably transfected with two distinct kinase-defective mutants of c-src." | 1.32 | Expression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-xL and increases oxaliplatin- and Fas-induced apoptosis. ( Brunton, VG; Cawthorne, C; Dive, C; Frame, MC; Greaves, M; Griffiths, GJ; Koh, MY; Ottley, CJ; Pearson, DG; Reeves, NA; Tilby, MJ; Workman, P, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, X | 1 |
| Feng, R | 1 |
| Duxbury, MS | 1 |
| Ito, H | 1 |
| Zinner, MJ | 1 |
| Ashley, SW | 1 |
| Whang, EE | 1 |
| Griffiths, GJ | 1 |
| Koh, MY | 1 |
| Brunton, VG | 1 |
| Cawthorne, C | 1 |
| Reeves, NA | 1 |
| Greaves, M | 1 |
| Tilby, MJ | 1 |
| Pearson, DG | 1 |
| Ottley, CJ | 1 |
| Workman, P | 1 |
| Frame, MC | 1 |
| Dive, C | 1 |
| Tan, M | 1 |
| Li, P | 1 |
| Sun, M | 1 |
| Yin, G | 1 |
| Yu, D | 1 |
4 other studies available for ag 1879 and Metastase
| Article | Year |
|---|---|
Inhibition of epithelial to mesenchymal transition in metastatic breast carcinoma cells by c-Src suppression.
Topics: Biomarkers, Tumor; Blotting, Western; Breast Neoplasms; Cadherins; Cell Line; Cell Line, Tumor; Cell | 2010 |
Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Blotting | 2004 |
Expression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-xL and increases oxaliplatin- and Fas-induced apoptosis.
Topics: Apoptosis; bcl-X Protein; Caspase 8; Caspases; Cell Line, Tumor; Colonic Neoplasms; CSK Tyrosine-Pro | 2004 |
Upregulation and activation of PKC alpha by ErbB2 through Src promotes breast cancer cell invasion that can be blocked by combined treatment with PKC alpha and Src inhibitors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carbazoles; Cell Line, Tumor; Enzy | 2006 |