ag 1879 has been researched along with Leukemia, Myelogenous, Chronic, BCR-ABL Positive in 3 studies
3-(4-chlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazolo(3,4-d)pyrimidin-4-amine: Fyn kinase inhibitor
Leukemia, Myelogenous, Chronic, BCR-ABL Positive: Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Williams, NK | 1 |
| Lucet, IS | 1 |
| Klinken, SP | 1 |
| Ingley, E | 1 |
| Rossjohn, J | 1 |
| Gamas, P | 1 |
| Marchetti, S | 1 |
| Puissant, A | 1 |
| Grosso, S | 1 |
| Jacquel, A | 1 |
| Colosetti, P | 1 |
| Pasquet, JM | 1 |
| Mahon, FX | 1 |
| Cassuto, JP | 1 |
| Auberger, P | 1 |
| Wilson, MB | 1 |
| Schreiner, SJ | 1 |
| Choi, HJ | 1 |
| Kamens, J | 1 |
| Smithgall, TE | 1 |
3 other studies available for ag 1879 and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
| Article | Year |
|---|---|
Crystal structures of the Lyn protein tyrosine kinase domain in its Apo- and inhibitor-bound state.
Topics: Adenylyl Imidodiphosphate; Animals; Apoenzymes; B-Lymphocytes; Catalytic Domain; Crystallography, X- | 2009 |
Inhibition of imatinib-mediated apoptosis by the caspase-cleaved form of the tyrosine kinase Lyn in chronic myelogenous leukemia cells.
Topics: Antineoplastic Agents; Apoptosis; Benzamides; Caspase 3; Caspase 9; Caspase Inhibitors; Enzyme Activ | 2009 |
Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis.
Topics: Apoptosis; Cell Division; Cell Transformation, Neoplastic; DNA-Binding Proteins; Dose-Response Relat | 2002 |