ag 1879 has been researched along with Invasiveness, Neoplasm in 17 studies
3-(4-chlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazolo(3,4-d)pyrimidin-4-amine: Fyn kinase inhibitor
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here we study the role of SFKs catalytic activity in triple-negative/basal-like and metastatic human breast cancer MDA-MB-231 cells employing three well-established inhibitors: Dasatinib, PP2 and SU6656." | 3.78 | Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells. ( Calcabrini, A; Gómez-Domínguez, D; Gómez-López, G; Martín-Forero, E; Martín-Pérez, J; Molinari, A; Morte, B; Sánchez-Bailón, MP; Wagner, KU, 2012) |
| "Knockdown of the SFKs in pancreatic cancer cells was achieved by transfecting small interfering RNAs, and its effects were investigated using proliferation, wound, and invasion assays." | 1.40 | The inhibition of SRC family kinase suppresses pancreatic cancer cell proliferation, migration, and invasion. ( Cho, Y; Je, DW; Ji, YG; Lee, DH; O, YM, 2014) |
| "BGC-823 gastric cancer cells were used to investigate migration following treatment of these cells with the c-Src inhibitors, PP2 and SU6656." | 1.40 | Role of c-Src activity in the regulation of gastric cancer cell migration. ( Bai, ZG; Wu, GC; Yang, Y; Yin, J; Zhang, ZT, 2014) |
| "Cell surface HSP90 promotes human prostate cancer cell invasion through a FAK/c-Src signaling, with may be a novel therapeutic target against metastatic tumors." | 1.37 | [FAK/c-Src signaling pathway mediates the expression of cell surface HSP90 in cultured human prostate cancer cells and its association with their invasive capability]. ( Guo, CA; Guo, MY; Guo, Y; Liu, XG; Yan, ZQ; Zhang, ZG, 2011) |
| "Although ErbB2 is known to enhance breast cancer metastasis, the signaling events responsible for this remain elusive." | 1.33 | Upregulation and activation of PKC alpha by ErbB2 through Src promotes breast cancer cell invasion that can be blocked by combined treatment with PKC alpha and Src inhibitors. ( Li, P; Sun, M; Tan, M; Yin, G; Yu, D, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (47.06) | 29.6817 |
| 2010's | 9 (52.94) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Isaías-Tizapa, R | 1 |
| Acosta, E | 1 |
| Tacuba-Saavedra, A | 1 |
| Mendoza-Catalán, M | 1 |
| Navarro-Tito, N | 1 |
| Ho, HC | 1 |
| Huang, CC | 1 |
| Lu, YT | 1 |
| Yeh, CM | 1 |
| Ho, YT | 1 |
| Yang, SF | 1 |
| Hsin, CH | 1 |
| Lin, CW | 1 |
| Gomes, C | 1 |
| Osório, H | 1 |
| Pinto, MT | 1 |
| Campos, D | 1 |
| Oliveira, MJ | 1 |
| Reis, CA | 1 |
| Komiya, E | 1 |
| Ohnuma, K | 1 |
| Yamazaki, H | 1 |
| Hatano, R | 1 |
| Iwata, S | 1 |
| Okamoto, T | 1 |
| Dang, NH | 1 |
| Yamada, T | 1 |
| Morimoto, C | 1 |
| Je, DW | 1 |
| O, YM | 1 |
| Ji, YG | 1 |
| Cho, Y | 1 |
| Lee, DH | 1 |
| Yang, Y | 1 |
| Bai, ZG | 1 |
| Yin, J | 1 |
| Wu, GC | 1 |
| Zhang, ZT | 1 |
| Yang, SZ | 1 |
| Zhang, LD | 1 |
| Zhang, Y | 1 |
| Xiong, Y | 1 |
| Zhang, YJ | 1 |
| Li, HL | 1 |
| Li, XW | 1 |
| Dong, JH | 1 |
| Enomoto, M | 1 |
| Hayakawa, S | 1 |
| Itsukushima, S | 1 |
| Ren, DY | 1 |
| Matsuo, M | 1 |
| Tamada, K | 1 |
| Oneyama, C | 1 |
| Okada, M | 1 |
| Takumi, T | 1 |
| Nishita, M | 1 |
| Minami, Y | 1 |
| Liu, XG | 1 |
| Guo, Y | 1 |
| Yan, ZQ | 1 |
| Guo, MY | 1 |
| Zhang, ZG | 1 |
| Guo, CA | 1 |
| Sánchez-Bailón, MP | 1 |
| Calcabrini, A | 1 |
| Gómez-Domínguez, D | 1 |
| Morte, B | 1 |
| Martín-Forero, E | 1 |
| Gómez-López, G | 1 |
| Molinari, A | 1 |
| Wagner, KU | 1 |
| Martín-Pérez, J | 1 |
| Bartscht, T | 1 |
| Lehnert, H | 1 |
| Gieseler, F | 1 |
| Ungefroren, H | 1 |
| Carlomagno, F | 1 |
| Vitagliano, D | 1 |
| Guida, T | 1 |
| Basolo, F | 1 |
| Castellone, MD | 1 |
| Melillo, RM | 1 |
| Fusco, A | 1 |
| Santoro, M | 1 |
| Boyd, DD | 1 |
| Wang, H | 1 |
| Avila, H | 1 |
| Parikh, NU | 1 |
| Kessler, H | 1 |
| Magdolen, V | 1 |
| Gallick, GE | 1 |
| Angers-Loustau, A | 1 |
| Hering, R | 1 |
| Werbowetski, TE | 1 |
| Kaplan, DR | 1 |
| Del Maestro, RF | 1 |
| Chiang, GJ | 1 |
| Billmeyer, BR | 1 |
| Canes, D | 1 |
| Stoffel, J | 1 |
| Moinzadeh, A | 1 |
| Austin, CA | 1 |
| Kosakowski, M | 1 |
| Rieger-Christ, KM | 1 |
| Libertino, JA | 1 |
| Summerhayes, IC | 1 |
| Tan, M | 1 |
| Li, P | 1 |
| Sun, M | 1 |
| Yin, G | 1 |
| Yu, D | 1 |
| Lin, CY | 1 |
| Lin, CJ | 1 |
| Chen, KH | 1 |
| Wu, JC | 1 |
| Huang, SH | 1 |
| Wang, SM | 1 |
17 other studies available for ag 1879 and Invasiveness, Neoplasm
| Article | Year |
|---|---|
The Leptin induced Hic-5 expression and actin puncta formation by the FAK/Src-dependent pathway in MCF10A mammary epithelial cells
Topics: Actins; Cell Line; Epithelial Cells; Epithelial-Mesenchymal Transition; Fanconi Anemia Complementati | 2019 |
Epigallocatechin-3-gallate inhibits migration of human nasopharyngeal carcinoma cells by repressing MMP-2 expression.
Topics: Catechin; Cell Line, Tumor; Cell Movement; Cell Survival; Humans; MAP Kinase Signaling System; Matri | 2019 |
Expression of ST3GAL4 leads to SLe(x) expression and induces c-Met activation and an invasive phenotype in gastric carcinoma cells.
Topics: Animals; beta-Galactoside alpha-2,3-Sialyltransferase; Cell Adhesion; Cell Line, Tumor; Chick Embryo | 2013 |
CD26-mediated regulation of periostin expression contributes to migration and invasion of malignant pleural mesothelioma cells.
Topics: Active Transport, Cell Nucleus; Cell Adhesion Molecules; Cell Line, Tumor; Cell Movement; Dipeptidyl | 2014 |
The inhibition of SRC family kinase suppresses pancreatic cancer cell proliferation, migration, and invasion.
Topics: Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Humans; Neoplasm | 2014 |
Role of c-Src activity in the regulation of gastric cancer cell migration.
Topics: Cell Line, Tumor; Cell Movement; CSK Tyrosine-Protein Kinase; Furin; Gene Expression Regulation, Neo | 2014 |
HBx protein induces EMT through c-Src activation in SMMC-7721 hepatoma cell line.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Epithelium; Hepatitis B virus; Humans; Liver Neoplasms; | 2009 |
Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signaling.
Topics: Cell Line, Tumor; Cell Movement; CSK Tyrosine-Protein Kinase; Enzyme Activation; Extracellular Matri | 2009 |
[FAK/c-Src signaling pathway mediates the expression of cell surface HSP90 in cultured human prostate cancer cells and its association with their invasive capability].
Topics: Antibodies; Cell Line, Tumor; Cell Membrane; Focal Adhesion Protein-Tyrosine Kinases; Gene Knockdown | 2011 |
Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dasatinib; Female; Humans; In | 2012 |
The Src family kinase inhibitors PP2 and PP1 effectively block TGF-beta1-induced cell migration and invasion in both established and primary carcinoma cells.
Topics: Cell Line, Tumor; Cell Movement; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neo | 2012 |
Efficient inhibition of RET/papillary thyroid carcinoma oncogenic kinases by 4-amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2).
Topics: 3T3 Cells; Animals; Carcinoma, Papillary; Cell Line, Transformed; Drosophila Proteins; Enzyme Activa | 2003 |
Combination of an SRC kinase inhibitor with a novel pharmacological antagonist of the urokinase receptor diminishes in vitro colon cancer invasiveness.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Blotting, Northern; Blotting, | 2004 |
SRC regulates actin dynamics and invasion of malignant glial cells in three dimensions.
Topics: Actin Cytoskeleton; Actins; Animals; Brain Neoplasms; Cell Line, Tumor; Cell Surface Extensions; CSK | 2004 |
The src-family kinase inhibitor PP2 suppresses the in vitro invasive phenotype of bladder carcinoma cells via modulation of Akt.
Topics: beta Catenin; Blotting, Western; Cadherins; Cell Line, Tumor; Cytoskeletal Proteins; Desmoplakins; g | 2005 |
Upregulation and activation of PKC alpha by ErbB2 through Src promotes breast cancer cell invasion that can be blocked by combined treatment with PKC alpha and Src inhibitors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carbazoles; Cell Line, Tumor; Enzy | 2006 |
Macrophage activation increases the invasive properties of hepatoma cells by destabilization of the adherens junction.
Topics: Adherens Junctions; Animals; beta Catenin; Cadherins; Carcinoma, Hepatocellular; Cell Movement; Cult | 2006 |