ag 1879 has been researched along with Disease Models, Animal in 15 studies
3-(4-chlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazolo(3,4-d)pyrimidin-4-amine: Fyn kinase inhibitor
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "After measures of mechanical allodynia returned to baseline, vehicle or the SFK inhibitor PP2 were injected intrathecally." | 1.56 | A Src family kinase maintains latent sensitization in rats, a model of inflammatory and neuropathic pain. ( Chen, W; Marvizón, JC, 2020) |
| "Previously, we have shown that brain hypoxia-induced production of caspases 1, 3, 8, and 9 is Src kinase mediated, a nonreceptor intracellular family of kinases." | 1.46 | Effects of Src kinase inhibition on expression of pro-caspase-2 after brain hypoxia in a piglet animal model. ( Angelis, D; Delivoria-Papadopoulos, M, 2017) |
| "Leishmaniasis is a devastating disease that disfigures or kills nearly two million people each year." | 1.43 | The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection. ( Koleske, AJ; Li, S; McMahon-Pratt, D; Rhodes, EL; Wetzel, DM, 2016) |
| "Papillary thyroid carcinoma is the most common thyroid malignancy." | 1.40 | Src inhibitors in suppression of papillary thyroid carcinoma growth. ( Chen, Y; Clayman, GL; Frederick, MJ; Gallick, GE; Henderson, YC; Lai, SY; Ryu, J; Toro-Serra, R; Zhou, G, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 9 (60.00) | 24.3611 |
| 2020's | 3 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Chen, W | 1 |
| Marvizón, JC | 1 |
| Pak, ES | 1 |
| Uddin, MJ | 1 |
| Ha, H | 1 |
| Angelis, D | 1 |
| Delivoria-Papadopoulos, M | 1 |
| Liu, ST | 1 |
| Zhong, SM | 1 |
| Li, XY | 1 |
| Gao, F | 2 |
| Li, F | 2 |
| Zhang, ML | 1 |
| Zhu, K | 1 |
| Sun, XH | 2 |
| Wang, X | 2 |
| Miao, Y | 2 |
| Yang, XL | 2 |
| Wang, Z | 2 |
| Henderson, YC | 1 |
| Toro-Serra, R | 1 |
| Chen, Y | 1 |
| Ryu, J | 1 |
| Frederick, MJ | 1 |
| Zhou, G | 1 |
| Gallick, GE | 1 |
| Lai, SY | 1 |
| Clayman, GL | 1 |
| Dong, LD | 1 |
| Wang, XH | 1 |
| Wang, SY | 1 |
| Wu, Y | 1 |
| Wu, J | 1 |
| Cheng, XL | 1 |
| Fan, GP | 1 |
| Wang, W | 1 |
| Zhao, H | 1 |
| Cai, L | 1 |
| Zhang, PD | 1 |
| Yang, ZH | 1 |
| Zhang, J | 1 |
| Wu, H | 1 |
| Shi, Y | 1 |
| Deng, X | 1 |
| Su, Y | 1 |
| Du, C | 1 |
| Wei, J | 1 |
| Ren, Y | 1 |
| Wu, M | 1 |
| Hou, Y | 1 |
| Duan, H | 1 |
| Wetzel, DM | 1 |
| Rhodes, EL | 1 |
| Li, S | 1 |
| McMahon-Pratt, D | 1 |
| Koleske, AJ | 1 |
| Liu, DZ | 1 |
| Waldau, B | 1 |
| Ander, BP | 1 |
| Zhan, X | 1 |
| Stamova, B | 1 |
| Jickling, GC | 1 |
| Lyeth, BG | 1 |
| Sharp, FR | 1 |
| Han, Y | 1 |
| Yuan, N | 1 |
| Zhang, SJ | 1 |
| Gao, J | 1 |
| Shi, Z | 1 |
| Zhou, YB | 1 |
| Gao, XY | 1 |
| Zhu, GQ | 1 |
| Kusaka, G | 1 |
| Kimura, H | 1 |
| Kusaka, I | 1 |
| Perkins, E | 1 |
| Nanda, A | 1 |
| Zhang, JH | 1 |
| Lennmyr, F | 1 |
| Ericsson, A | 1 |
| Gerwins, P | 1 |
| Akterin, S | 1 |
| Ahlström, H | 1 |
| Terént, A | 1 |
| Thobe, BM | 1 |
| Frink, M | 1 |
| Choudhry, MA | 1 |
| Schwacha, MG | 1 |
| Bland, KI | 1 |
| Chaudry, IH | 1 |
15 other studies available for ag 1879 and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
A Src family kinase maintains latent sensitization in rats, a model of inflammatory and neuropathic pain.
Topics: Animals; Central Nervous System Sensitization; Disease Models, Animal; Hyperalgesia; Inflammation; M | 2020 |
Inhibition of Src Family Kinases Ameliorates LPS-Induced Acute Kidney Injury and Mitochondrial Dysfunction in Mice.
Topics: Acute Kidney Injury; Animals; Cells, Cultured; Disease Models, Animal; Lipopolysaccharides; Male; Mi | 2020 |
Effects of Src kinase inhibition on expression of pro-caspase-2 after brain hypoxia in a piglet animal model.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Blotting, Western; Caspase 2; Cerebral Cortex; Cy | 2017 |
EphrinB/EphB forward signaling in Müller cells causes apoptosis of retinal ganglion cells by increasing tumor necrosis factor alpha production in rat experimental glaucomatous model.
Topics: Animals; Animals, Newborn; Antioxidants; Apoptosis; Cells, Cultured; Chromones; Disease Models, Anim | 2018 |
Src inhibitors in suppression of papillary thyroid carcinoma growth.
Topics: Animals; Carcinoma; Carcinoma, Papillary; Cell Proliferation; Dasatinib; Disease Models, Animal; Ind | 2014 |
GluA2 trafficking is involved in apoptosis of retinal ganglion cells induced by activation of EphB/EphrinB reverse signaling in a rat chronic ocular hypertension model.
Topics: Animals; Apoptosis; Disease Models, Animal; Ephrin-B2; Excitatory Postsynaptic Potentials; In Situ N | 2015 |
Pharmacological Inhibition of Focal Adhesion Kinase Attenuates Cardiac Fibrosis in Mice Cardiac Fibroblast and Post-Myocardial-Infarction Models.
Topics: Animals; Animals, Newborn; Cell Differentiation; Cell Hypoxia; Disease Models, Animal; Fibroblasts; | 2015 |
Inhibition of c-Src/p38 MAPK pathway ameliorates renal tubular epithelial cells apoptosis in db/db mice.
Topics: Animals; Apoptosis; Cell Line; Diabetic Nephropathies; Disease Models, Animal; Drug Administration S | 2015 |
The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection.
Topics: Aniline Compounds; Animals; Cytokines; Disease Models, Animal; Imatinib Mesylate; Immunoglobulin G; | 2016 |
Inhibition of Src family kinases improves cognitive function after intraventricular hemorrhage or intraventricular thrombin.
Topics: Animals; Cerebral Ventricles; Cognitive Dysfunction; Disease Models, Animal; Enzyme Inhibitors; Fema | 2017 |
c-Src in paraventricular nucleus modulates sympathetic activity and cardiac sympathetic afferent reflex in renovascular hypertensive rats.
Topics: Angiotensin II; Animals; Blood Pressure; Capsaicin; CSK Tyrosine-Protein Kinase; Disease Models, Ani | 2011 |
Contribution of Src tyrosine kinase to cerebral vasospasm after subarachnoid hemorrhage.
Topics: Animals; Anthraquinones; Blotting, Western; Cerebral Angiography; Disease Models, Animal; Dogs; Fema | 2003 |
Src family kinase-inhibitor PP2 reduces focal ischemic brain injury.
Topics: Animals; Brain; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Infarction, Middle Cere | 2004 |
Src family kinases regulate p38 MAPK-mediated IL-6 production in Kupffer cells following hypoxia.
Topics: Animals; Cell Separation; Chemokine CCL2; Disease Models, Animal; Hypoxia; Interleukin-6; Kupffer Ce | 2006 |