ag 1879 has been researched along with Breast Cancer in 18 studies
3-(4-chlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazolo(3,4-d)pyrimidin-4-amine: Fyn kinase inhibitor
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have examined the effect of Apc loss in MMTV-PyMT mouse breast cancer cells on gene expression changes of ATP-binding cassette transporters and immunofluorescence to determine proliferative and apoptotic response of cells to cisplatin, doxorubicin and paclitaxel." | 3.81 | APC selectively mediates response to chemotherapeutic agents in breast cancer. ( Bedalov, CO; Prosperi, JR; Soto, KF; VanKlompenberg, MK, 2015) |
| " Here we study the role of SFKs catalytic activity in triple-negative/basal-like and metastatic human breast cancer MDA-MB-231 cells employing three well-established inhibitors: Dasatinib, PP2 and SU6656." | 3.78 | Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells. ( Calcabrini, A; Gómez-Domínguez, D; Gómez-López, G; Martín-Forero, E; Martín-Pérez, J; Molinari, A; Morte, B; Sánchez-Bailón, MP; Wagner, KU, 2012) |
| " In the present study, we used transferrin (Tf), a known ligand of TfR1, and gambogic acid (GA), an apoptosis-inducing agent and newly identified TfR1 ligand to investigate the signaling role of TfR1 in breast cancer cells." | 3.77 | Src regulates Tyr(20) phosphorylation of transferrin receptor-1 and potentiates breast cancer cell survival. ( Huang, X; Jian, J; Yang, Q, 2011) |
| "Triple-negative breast cancer (TNBC) cell lines with a mesenchymal phenotype are sensitive to TRAIL, whereas other breast cancer cell lines are resistant." | 1.40 | Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening. ( Caplen, NJ; Chakka, S; Dine, JL; Garimella, SV; Gehlhaus, K; Grandin, M; Lipkowitz, S; Nau, MM; Pitt, JJ, 2014) |
| "Cultured breast cancer Hs578T cells were treated with various concentrations of pp2 (0,1,2,4,8,16,32 μmol/L) for 24h." | 1.39 | [PP2 enhances intercellular communication of gap junction in breast cancer Hs578T cells]. ( Dong, SY; Han, X; Jiang, GJ; Tong, XH; Zheng, C, 2013) |
| "Here we report that in MTLy breast cancer cells CD24 interacts with and augments the kinase activity of c-src, a protein strongly implicated in promoting invasion and metastasis." | 1.38 | CD24 interacts with and promotes the activity of c-src within lipid rafts in breast cancer cells, thereby increasing integrin-dependent adhesion. ( Allgayer, H; Baumann, P; Cremers, N; Diefenbacher, M; Frame, M; Kassel, O; Krachulec, J; Mudduluru, G; Muppala, S; Sleeman, JP; Thiele, W, 2012) |
| "Although ErbB2 is known to enhance breast cancer metastasis, the signaling events responsible for this remain elusive." | 1.33 | Upregulation and activation of PKC alpha by ErbB2 through Src promotes breast cancer cell invasion that can be blocked by combined treatment with PKC alpha and Src inhibitors. ( Li, P; Sun, M; Tan, M; Yin, G; Yu, D, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (27.78) | 29.6817 |
| 2010's | 13 (72.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Carraro, F | 1 |
| Pucci, A | 1 |
| Naldini, A | 1 |
| Schenone, S | 1 |
| Bruno, O | 1 |
| Ranise, A | 1 |
| Bondavalli, F | 1 |
| Brullo, C | 1 |
| Fossa, P | 1 |
| Menozzi, G | 1 |
| Mosti, L | 1 |
| Manetti, F | 1 |
| Botta, M | 1 |
| Kumar, A | 1 |
| Ahmad, I | 1 |
| Chhikara, BS | 1 |
| Tiwari, R | 1 |
| Mandal, D | 1 |
| Parang, K | 1 |
| Dong, SY | 1 |
| Zheng, C | 1 |
| Jiang, GJ | 1 |
| Han, X | 1 |
| Tong, XH | 1 |
| Fan, P | 2 |
| Agboke, FA | 1 |
| McDaniel, RE | 2 |
| Sweeney, EE | 1 |
| Zou, X | 1 |
| Creswell, K | 1 |
| Jordan, VC | 2 |
| Garimella, SV | 1 |
| Gehlhaus, K | 1 |
| Dine, JL | 1 |
| Pitt, JJ | 1 |
| Grandin, M | 1 |
| Chakka, S | 1 |
| Nau, MM | 1 |
| Caplen, NJ | 1 |
| Lipkowitz, S | 1 |
| VanKlompenberg, MK | 1 |
| Bedalov, CO | 1 |
| Soto, KF | 1 |
| Prosperi, JR | 1 |
| Mitra, PS | 1 |
| Basu, NK | 1 |
| Owens, IS | 1 |
| Strell, C | 1 |
| Lang, K | 1 |
| Niggemann, B | 1 |
| Zaenker, KS | 1 |
| Entschladen, F | 1 |
| Liu, X | 1 |
| Feng, R | 1 |
| Zhang, XT | 1 |
| Kang, LG | 1 |
| Ding, L | 1 |
| Vranic, S | 1 |
| Gatalica, Z | 1 |
| Wang, ZY | 1 |
| Mitchell, C | 1 |
| Hamed, HA | 1 |
| Cruickshanks, N | 1 |
| Tang, Y | 1 |
| Bareford, MD | 1 |
| Hubbard, N | 1 |
| Tye, G | 1 |
| Yacoub, A | 1 |
| Dai, Y | 1 |
| Grant, S | 1 |
| Dent, P | 1 |
| Baumann, P | 1 |
| Thiele, W | 1 |
| Cremers, N | 1 |
| Muppala, S | 1 |
| Krachulec, J | 1 |
| Diefenbacher, M | 1 |
| Kassel, O | 1 |
| Mudduluru, G | 1 |
| Allgayer, H | 1 |
| Frame, M | 1 |
| Sleeman, JP | 1 |
| Jian, J | 1 |
| Yang, Q | 1 |
| Huang, X | 1 |
| Sánchez-Bailón, MP | 1 |
| Calcabrini, A | 1 |
| Gómez-Domínguez, D | 1 |
| Morte, B | 1 |
| Martín-Forero, E | 1 |
| Gómez-López, G | 1 |
| Molinari, A | 1 |
| Wagner, KU | 1 |
| Martín-Pérez, J | 1 |
| Kim, HR | 1 |
| Clagett, D | 1 |
| Haddad, B | 1 |
| Lynch, L | 1 |
| Vodyanik, PI | 1 |
| Boettiger, D | 1 |
| Guvakova, MA | 1 |
| Tan, M | 1 |
| Li, P | 1 |
| Sun, M | 1 |
| Yin, G | 1 |
| Yu, D | 1 |
| Ishizawar, RC | 1 |
| Miyake, T | 1 |
| Parsons, SJ | 1 |
18 other studies available for ag 1879 and Breast Cancer
| Article | Year |
|---|---|
Pyrazolo[3,4-d]pyrimidines endowed with antiproliferative activity on ductal infiltrating carcinoma cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Cell Line, Tumor; Drug Screening Assays, Ant | 2004 |
Synthesis of 3-phenylpyrazolopyrimidine-1,2,3-triazole conjugates and evaluation of their Src kinase inhibitory and anticancer activities.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Fe | 2011 |
[PP2 enhances intercellular communication of gap junction in breast cancer Hs578T cells].
Topics: Breast Neoplasms; Cell Line, Tumor; Female; Gap Junctions; Humans; Pyrimidines; src-Family Kinases | 2013 |
Inhibition of c-Src blocks oestrogen-induced apoptosis and restores oestrogen-stimulated growth in long-term oestrogen-deprived breast cancer cells.
Topics: Animals; Apoptosis; Breast Neoplasms; Cadherins; Cell Proliferation; Estradiol; Estrogens; Fulvestra | 2014 |
Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening.
Topics: Apoptosis; bcl-X Protein; Biphenyl Compounds; Breast Neoplasms; Caspase 3; Caspase 7; Caspase 8; Cel | 2014 |
APC selectively mediates response to chemotherapeutic agents in breast cancer.
Topics: Adenomatous Polyposis Coli Protein; Animals; Anthracenes; Apoptosis; Breast Neoplasms; Carcinogenesi | 2015 |
Src supports UDP-glucuronosyltransferase-2B7 detoxification of catechol estrogens associated with breast cancer.
Topics: Animals; Benzoquinones; Breast Neoplasms; Chlorocebus aethiops; COS Cells; DNA Damage; Estrogens, Ca | 2009 |
Neutrophil granulocytes promote the migratory activity of MDA-MB-468 human breast carcinoma cells via ICAM-1.
Topics: Antibodies, Monoclonal; Breast Neoplasms; Calcium Signaling; Cell Communication; Cell Line, Tumor; C | 2010 |
Inhibition of epithelial to mesenchymal transition in metastatic breast carcinoma cells by c-Src suppression.
Topics: Biomarkers, Tumor; Blotting, Western; Breast Neoplasms; Cadherins; Cell Line; Cell Line, Tumor; Cell | 2010 |
A positive feedback loop of ER-α36/EGFR promotes malignant growth of ER-negative breast cancer cells.
Topics: Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Cell Prolif | 2011 |
Simultaneous exposure of transformed cells to SRC family inhibitors and CHK1 inhibitors causes cell death.
Topics: Animals; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; bcl-X Protein; Benz | 2011 |
CD24 interacts with and promotes the activity of c-src within lipid rafts in breast cancer cells, thereby increasing integrin-dependent adhesion.
Topics: Anti-Bacterial Agents; Breast Neoplasms; CD24 Antigen; Cell Adhesion; Cell Line, Tumor; Cell Movemen | 2012 |
Src regulates Tyr(20) phosphorylation of transferrin receptor-1 and potentiates breast cancer cell survival.
Topics: Animals; Antigens, CD; Apoptosis; Breast Neoplasms; Caspase 3; Cell Line, Tumor; Cell Survival; CHO | 2011 |
Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dasatinib; Female; Humans; In | 2012 |
Modulating therapeutic effects of the c-Src inhibitor via oestrogen receptor and human epidermal growth factor receptor 2 in breast cancer cell lines.
Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Divis | 2012 |
Insulin-like growth factor I controls adhesion strength mediated by alpha5beta1 integrins in motile carcinoma cells.
Topics: Actins; Amides; Blotting, Western; Breast Neoplasms; Butadienes; Carcinoma; Catalysis; Cell Adhesion | 2005 |
Upregulation and activation of PKC alpha by ErbB2 through Src promotes breast cancer cell invasion that can be blocked by combined treatment with PKC alpha and Src inhibitors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carbazoles; Cell Line, Tumor; Enzy | 2006 |
c-Src modulates ErbB2 and ErbB3 heterocomplex formation and function.
Topics: Animals; Breast Neoplasms; Cell Movement; Cells, Cultured; CSK Tyrosine-Protein Kinase; Enzyme Inhib | 2007 |