afn-1252 and Gram-Negative-Bacterial-Infections

afn-1252 has been researched along with Gram-Negative-Bacterial-Infections* in 1 studies

Other Studies

1 other study(ies) available for afn-1252 and Gram-Negative-Bacterial-Infections

Article	Year
Implementation of permeation rules leads to a FabI inhibitor with activity against Gram-negative pathogens. Nature microbiology, 2020, Volume: 5, Issue:1 Gram-negative bacterial infections are a significant public health concern, and the lack of new drug classes for these pathogens is linked to the inability of most drug leads to accumulate inside Gram-negative bacteria Topics: Animals; Anti-Bacterial Agents; Benzofurans; Cell Line; Cell Survival; Drug Discovery; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Enzyme Inhibitors; Escherichia coli; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Humans; Mice; Microbial Sensitivity Tests; Pyrones; Software; Structure-Activity Relationship	2020

Article

Year

Implementation of permeation rules leads to a FabI inhibitor with activity against Gram-negative pathogens.

Nature microbiology, 2020, Volume: 5, Issue:1

Gram-negative bacterial infections are a significant public health concern, and the lack of new drug classes for these pathogens is linked to the inability of most drug leads to accumulate inside Gram-negative bacteria

Topics: Animals; Anti-Bacterial Agents; Benzofurans; Cell Line; Cell Survival; Drug Discovery; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Enzyme Inhibitors; Escherichia coli; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Humans; Mice; Microbial Sensitivity Tests; Pyrones; Software; Structure-Activity Relationship

2020