aflatoxin b1 has been researched along with Cell Transformation, Neoplastic in 56 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 23 (41.07) | 18.7374 |
1990's | 13 (23.21) | 18.2507 |
2000's | 11 (19.64) | 29.6817 |
2010's | 8 (14.29) | 24.3611 |
2020's | 1 (1.79) | 2.80 |
Authors | Studies |
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Clausen, N; Elgart, B; Foley, JF; Gerrish, K; Gladwell, W; Mav, D; Merrick, BA; Phadke, D; Shah, R; Tripodi, I; Weick, M | 1 |
Auerbach, SS; Mav, D; Merrick, BA; Phadke, DP; Shah, RR; Stiegelmeyer, SM; Tice, RR | 1 |
Huan, F; Lu, H; Meghan, C; Wang, SL; Wang, X; Wang, Y; Yang, X; Zhang, Z | 1 |
Chen, Z; Ji, J; Li, J; Wang, H; Yang, L | 1 |
Feng, Y; Guo, Z; Lian, J; Srinivas, S; Wang, S; Yang, W; Zhong, H; Zhuang, Z | 1 |
Gao, W; Ji, M; Sun, Z; Wang, C; Wang, H; Wang, SL; Wang, Y; Xu, H; Zhang, Y; Zhang, Z | 1 |
Accardi, R; Cosset, FL; Fusil, F; Gheit, T; Gruffat, H; Hernandez-Vargas, H; Le Calvez-Kelm, F; Manet, E; Sirand, C; Tommasino, M; Traverse-Glehen, A; Wild, CP | 1 |
Baumgartner, KJ; Dinkova-Kostova, AT; Egner, PA; Gribble, GW; Groopman, JD; Honda, T; Kensler, TW; Liby, K; Risingsong, R; Roebuck, BD; Royce, DB; Sporn, MB; Stephenson, KK; Sundararajan, C; Williams, CR; Yates, MS; Yore, MM; Yoshizawa, H | 1 |
Chen, L; Chen, W; Ji, W; Lai, Y; Li, D; Li, W; Lin, Y; Ma, R; Pang, Y; Tang, S; Wang, Q; Wei, Q; Xiao, Y; Yang, P; Zheng, Y; Zhuang, Z | 1 |
Dedon, PC; Doernte, AL; Essigmann, JM; Feng, Y; Fiala, JL; Fox, JG; Fry, RC; Lemon, SM; McFaline, JL; Raczynski, AR; Rogers, AB; Schauer, DB; Tannenbaum, SR; Theve, EJ; Weinman, SA; Williams, M | 1 |
Drouin, R; Lacoste, S; Rochette, PJ | 1 |
Anpo, M; Barrett, JC; Kanai, H; Kato, T; Kumakura, S; Tahara, H; Tamura, Y; Tsutsui, T; Yamamoto, A | 1 |
Farmer, PB; Sharma, RA | 1 |
Gopalan-Kriczky, P; Kimura, M; Lehmann, K; Lotlikar, PD | 1 |
Galendo, D; Lee, MK; Sabapathy, K; Tong, WM; Wang, ZQ | 1 |
Dixon, KR; Lian, M; Liu, Y; Qian, GS; Wan, SG; Yu, SZ | 1 |
Bailey, GS; Hendricks, JD; Orner, GA; Pereira, CB; Tilton, SC; Williams, DE | 1 |
Ban, KC; Cao, J; Chen, MW; Jiao, Y; Su, JJ; Yue, HY | 1 |
Cortesi, E; Donovan, PJ; Kakunaga, T; Rice, JM; Saffiotti, U | 1 |
Enwonwu, CO | 1 |
Boynton, AL; Kleine, LP; Whitfield, JF | 1 |
Curtis, G; Garland, H; Nesnow, S | 1 |
Amstad, PA; Cerutti, PA; Wang, TV | 1 |
Billings, PC; Heidelberger, C; Uwaifo, AO | 2 |
Frayssinet, C; Lafarge-Frayssinet, C; Morel-Chany, E; Trincal, G | 1 |
Schaeffer, WI | 1 |
Balwierz, PS; Oshiro, Y | 1 |
Abernethy, DJ; Boreiko, CJ; Frazelle, JH; Ragan, DL | 1 |
Blum, HE | 1 |
Aguilar, F; Cerutti, P; Hussain, P; Pourzand, C | 1 |
Casto, BC; Chen, J; Li, D; Milo, GE; Noyes, I; Shuler, C; Theil, K | 1 |
Yap, I | 1 |
Guengerich, FP; Kim, MS; Lowe, LG; Müller, M | 1 |
Benjamin, T; Hoang, T; Luo, LD; Wirth, PJ | 1 |
Dolan, PM; Egner, PA; Gange, SJ; Groopman, JD; Kensler, TW; Muñoz, A; Roebuck, BD; Rogers, AE | 1 |
Higginson, FM; Judah, DJ; Mandel, HG; Neal, GE; Riley, J; Sinha, S; Stanley, LA | 1 |
Sun, Z; Yuan, B | 1 |
Guengerich, FP | 1 |
Lotlikar, PD; Ning, Y; Qin, G | 1 |
Carthew, P; Green, JA; Heuillet, E; Manson, MM; Simpson, JL | 1 |
Dunn, JA; Faletto, MB; Gurtoo, HL; Kasper, SJ | 1 |
Ramesh, HP; Rati, ER; Shantha, T | 1 |
Ersing, N; Faletto, MB; Gurtoo, HL; Kouli, F; Maccubbin, AE; Vangalio, JA | 1 |
Faletto, MB; Gurtoo, HL; Koser, PL; Maccubbin, AE; Vangalio, JA | 1 |
Maeura, Y; Tanaka, T; Williams, GM | 1 |
Hockin, LJ; Neal, GE; Sinha, S | 1 |
Boix, J; Callaghan, R; Gil, R; Llombart-Bosch, A; Pellin, A | 1 |
Modali, R; Taub, JV; Vieira, W; Yang, GC; Yang, SS; Yasei, P | 1 |
Hayashi, K; Horikoshi, N; Kawamura, H; Makino, R; Morimura, S; Nemoto, K; Ohtsubo, K; Sugimura, T; Tashiro, F; Ueno, Y | 1 |
Lubet, RA; McCarvill, JT; Putman, DL; Schechtman, LM; Schwartz, JL | 1 |
del Campo, AA; McMahon, JB; Richards, WL; Song, MK; Thorgeirsson, SS | 1 |
Hanson, L; Lee, JJ; McMahon, G; Wogan, GN | 1 |
Davis, E; McMahon, G; Wogan, GN | 1 |
Manson, MM; Neal, GE; Power, C; Sinha, S; Webber, C | 1 |
Kiss, E; Kouri, RE; Lubet, RA; McCarvill, J; Nims, R; Schechtman, LM | 1 |
6 review(s) available for aflatoxin b1 and Cell Transformation, Neoplastic
Article | Year |
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[Mapping DNA damage to understand somatic mutagenesis].
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aflatoxin B1; Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Codon; DNA; DNA Damage; DNA Methylation; DNA Repair; Genes, p53; Humans; Liver Neoplasms; Lung Neoplasms; Mutagenesis; Neoplasms, Radiation-Induced; Polymerase Chain Reaction; Skin Neoplasms; Sunlight; Ultraviolet Rays | 2010 |
Biological relevance of adduct detection to the chemoprevention of cancer.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aflatoxin B1; Anticarcinogenic Agents; Antioxidants; Biomarkers, Tumor; Carcinogens; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Clinical Trials as Topic; Deoxyguanosine; Diet; DNA; DNA Adducts; DNA Damage; DNA Repair; Humans; Immunochemistry; Male; Mass Spectrometry; Models, Chemical; Neoplasms; Oxidative Stress; Oxygen; Prostatic Neoplasms; Proteins; Risk; Sensitivity and Specificity | 2004 |
[Hepatocellular carcinoma: molecular biology aspects].
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Hepatitis B; Hepatitis C; Humans; Liver Cirrhosis, Alcoholic; Liver Neoplasms | 1994 |
Mutagenesis of the H-ras protooncogene and the p53 tumor suppressor gene.
Topics: Aflatoxin B1; Base Sequence; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Codon; DNA Primers; Ethylnitrosourea; Genes, p53; Genes, ras; Humans; Liver Neoplasms; Molecular Sequence Data; Mutagenesis; Neoplasms; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Proto-Oncogenes; Urinary Bladder Neoplasms | 1994 |
Hepatocellular carcinoma--carcinogenesis updated.
Topics: Aflatoxin B1; Carcinogens, Environmental; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Hepatitis B; Humans; Liver; Liver Neoplasms; Risk Factors | 1995 |
Chemical mechanisms of formation of DNA-carcinogen adducts, elucidation of potential of adducts for mutagenicity, and mechanisms of polymerase fidelity and mutation in the presence of adducts.
Topics: Aflatoxin B1; Animals; Base Sequence; Carcinogens; Cell Transformation, Neoplastic; DNA Adducts; DNA Polymerase II; DNA-Directed DNA Polymerase; Escherichia coli; Humans; Kinetics; Models, Biological; Mutagenesis; Substrate Specificity | 1997 |
50 other study(ies) available for aflatoxin b1 and Cell Transformation, Neoplastic
Article | Year |
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Whole exome and transcript profiling of liver following aflatoxin B1 exposure in rats.
Topics: Aflatoxin B1; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Exome; Liver; Liver Neoplasms; Rats; Rats, Inbred F344 | 2023 |
RNA-Seq profiling reveals novel hepatic gene expression pattern in aflatoxin B1 treated rats.
Topics: Aflatoxin B1; Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; E2F1 Transcription Factor; Exons; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Glucuronosyltransferase; High-Throughput Nucleotide Sequencing; Liver; Liver Neoplasms, Experimental; Male; Oligonucleotide Array Sequence Analysis; Precancerous Conditions; Principal Component Analysis; Rats; RNA, Messenger; Sequence Analysis, RNA; Transcriptome | 2013 |
Cytochrome P450 2A13 mediates the neoplastic transformation of human bronchial epithelial cells at a low concentration of aflatoxin B1.
Topics: Aflatoxin B1; Animals; Apoptosis; Aryl Hydrocarbon Hydroxylases; Ataxia Telangiectasia Mutated Proteins; bcl-2-Associated X Protein; Bronchi; Caspase 3; Cell Line; Cell Movement; Cell Transformation, Neoplastic; Cytochrome P-450 Enzyme System; DNA Adducts; DNA Repair; Epithelial Cells; Humans; Mice; Mice, Nude; Poly(ADP-ribose) Polymerases; Up-Regulation | 2014 |
Transcriptome profiling of malignant transformed rat hepatic stem-like cells by aflatoxin B1.
Topics: Aflatoxin B1; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Neoplastic Stem Cells; Rats; Signal Transduction | 2014 |
Genome-wide miRNA-profiling of aflatoxin B1-induced hepatic injury using deep sequencing.
Topics: Aflatoxin B1; Animals; Base Sequence; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Chemical and Drug Induced Liver Injury; Computational Biology; Databases, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genetic Markers; High-Throughput Nucleotide Sequencing; Liver; Liver Neoplasms; Male; MicroRNAs; Molecular Sequence Data; Rats; Rats, Inbred F344; Reproducibility of Results; RNA Precursors | 2014 |
miR-138-1* regulates aflatoxin B1-induced malignant transformation of BEAS-2B cells by targeting PDK1.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; 3' Untranslated Regions; Aflatoxin B1; Aryl Hydrocarbon Hydroxylases; Binding Sites; Bronchi; Cell Line; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Epithelial Cells; Gene Expression Profiling; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; MicroRNAs; RNA Interference; Signal Transduction; Time Factors; Transfection | 2016 |
The mycotoxin aflatoxin B1 stimulates Epstein-Barr virus-induced B-cell transformation in in vitro and in vivo experimental models.
Topics: Aflatoxin B1; Animals; B-Lymphocytes; Burkitt Lymphoma; Carcinogenesis; Cell Transformation, Neoplastic; Cells, Cultured; Environmental Exposure; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Humans; Male; Mice, Inbred NOD; Mice, SCID; Signal Transduction; Virus Activation; Virus Replication | 2015 |
A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin.
Topics: Administration, Oral; Aflatoxin B1; Animals; Apoptosis; Cell Differentiation; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; DNA Adducts; Heme Oxygenase-1; Humans; Imidazoles; Leukemia; Liver Neoplasms; Macrophages; Male; Mice; Molecular Structure; NAD(P)H Dehydrogenase (Quinone); Nitric Oxide; Nitric Oxide Synthase Type II; Oleanolic Acid; Phenanthrenes; Rats; Rats, Inbred F344; Reactive Oxygen Species | 2008 |
Development of human cell models for assessing the carcinogenic potential of chemicals.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aflatoxin B1; Animals; Benzo(a)pyrene; Bronchi; Carcinogenicity Tests; Cell Line; Cell Transformation, Neoplastic; Chromosome Aberrations; Cytochrome P-450 CYP1A1; Genes, myc; Genes, ras; Humans; Mice; Mice, Inbred BALB C; Nickel | 2008 |
Gut microbes define liver cancer risk in mice exposed to chemical and viral transgenic hepatocarcinogens.
Topics: Adaptive Immunity; Aflatoxin B1; Animals; Cell Proliferation; Cell Transformation, Neoplastic; Chemokines; Cocarcinogenesis; Female; Helicobacter hepaticus; Helicobacter Infections; Hepatitis B; Immunity, Innate; Interleukin-12 Subunit p40; Intestines; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Transgenic; Oxidative Stress; Sex Factors; Signal Transduction; Th1 Cells | 2010 |
Association of p16(INK4a) and pRb inactivation with immortalization of human cells.
Topics: 4-Nitroquinoline-1-oxide; Aflatoxin B1; Carcinogens; Cell Cycle; Cell Line; Cell Transformation, Neoplastic; Cobalt Radioisotopes; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA-Binding Proteins; DNA, Complementary; Fibroblasts; Humans; Keratinocytes; Oncogene Proteins, Viral; Phosphorylation; Repressor Proteins; Retinoblastoma Protein; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Telomerase; Telomere; Time Factors; Tumor Cells, Cultured; X-Rays | 2002 |
Effect of diet on aflatoxin B1-DNA binding and aflatoxin B1-induced glutathione S-transferase placental form positive hepatic foci in the rat.
Topics: Aflatoxin B1; Animals; Cell Transformation, Neoplastic; Cytochrome P-450 Enzyme System; Diet; DNA; Glutathione Transferase; Hepatocytes; Liver Neoplasms; Microsomes, Liver; Rats | 2004 |
Aflatoxin-B exposure does not lead to p53 mutations but results in enhanced liver cancer of Hupki (human p53 knock-in) mice.
Topics: Aflatoxin B1; Animals; Base Sequence; Cell Transformation, Neoplastic; DNA, Complementary; Humans; Liver Neoplasms; Mice; Mice, Transgenic; Molecular Sequence Data; Mutation; Survival Rate; Tumor Suppressor Protein p53 | 2006 |
Hepatitis B virus x gene and cyanobacterial toxins promote aflatoxin B1-induced hepatotumorigenesis in mice.
Topics: Aflatoxin B1; Animals; Bacterial Toxins; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cyanobacteria Toxins; Dose-Response Relationship, Drug; Drug Synergism; Liver Neoplasms; Male; Marine Toxins; Mice; Mice, Transgenic; Microcystins; Peptides, Cyclic; Poisons; Polymerase Chain Reaction; Time Factors; Trans-Activators; Viral Regulatory and Accessory Proteins | 2006 |
Gene expression analysis during tumor enhancement by the dietary phytochemical, 3,3'-diindolylmethane, in rainbow trout.
Topics: Aflatoxin B1; Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Dietary Supplements; Estradiol; Gene Expression Profiling; Indoles; Liver; Liver Neoplasms; Oligonucleotide Array Sequence Analysis; Oncorhynchus mykiss; Plant Preparations | 2007 |
[Changes of beta catenin in carcinogenesis in rat livers induced by aflatoxin B1].
Topics: Aflatoxin B1; Animals; beta Catenin; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Liver; Male; Rats; Rats, Sprague-Dawley | 2007 |
Dose-response studies on neoplastic transformation of BALB/3T3 clone A31-1-1 cells by aflatoxin B1, benzidine, benzo[a]pyrene, 3-methylcholanthrene, and N-methyl-N'-nitro-N-nitrosoguanidine.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzidines; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Clone Cells; Methylcholanthrene; Methylnitronitrosoguanidine; Mice; Mice, Inbred BALB C | 1983 |
The role of dietary aflatoxin in the genesis of hepatocellular cancer in developing countries.
Topics: Aflatoxin B1; Aflatoxins; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Child; Cocarcinogenesis; Developing Countries; Dietary Proteins; DNA Replication; Food Contamination; Hepatitis B; Humans; Kwashiorkor; Liver; Liver Neoplasms; Microsomes, Liver; Mixed Function Oxygenases | 1984 |
Ca2+/phospholipid-dependent protein kinase activity correlates to the ability of transformed liver cells to proliferate in Ca2+-deficient medium.
Topics: Aflatoxin B1; Aflatoxins; Animals; Calcium Chloride; Carcinogens; Cell Division; Cell Line; Cell Transformation, Neoplastic; DNA Replication; Kinetics; Liver; Liver Neoplasms; Precancerous Conditions; Protein Kinase C; Protein Kinases; Rats | 1983 |
Improved transformation of C3H10T1/2CL8 cells by direct- and indirect-acting carcinogens.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Methylnitronitrosoguanidine; Mice; Probability | 1982 |
Removal of aflatoxin B1-DNA adducts and in vitro transformation in mouse embryo fibroblasts C3H/10T1 1/2.
Topics: Aflatoxin B1; Aflatoxins; Animals; Carbon Radioisotopes; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Chromatography, High Pressure Liquid; DNA; DNA Replication; Embryo, Mammalian; Kinetics; Mice; Mice, Inbred C3H; Tritium | 1983 |
Mutation of Chinese Hamster V79 cells and transformation and mutation of mouse fibroblast C3H/10T1/2 clone 8 cells by aflatoxin B1 and four other furocoumarins isolated from two Nigerian medicinal plants.
Topics: Aflatoxin B1; Aflatoxins; Animals; Cell Survival; Cell Transformation, Neoplastic; Coumarins; Cricetinae; Cricetulus; Fibroblasts; Furocoumarins; Lung; Methoxsalen; Mice; Mice, Inbred C3H; Nigeria; Plants, Medicinal | 1983 |
Promoting effect of biliverdin for liver cells initiated by aflatoxin B1.
Topics: Aflatoxin B1; Aflatoxins; Animals; Bilirubin; Biliverdine; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinogenesis; Contact Inhibition; Liver; Rats; Rats, Inbred Strains | 1983 |
Influence of benzoflavone on aflatoxin B1-induced cytotoxicity, mutation, and transformation of C3H/10T1/2 cells.
Topics: Aflatoxin B1; Aflatoxins; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Flavonoids; Mice; Mice, Inbred C3H; Mutagenicity Tests; Mutation | 1983 |
The long-term culture of a diploid rat hepatocyte cell strain.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzopyrenes; Carcinoma; Cell Division; Cell Line; Cell Transformation, Neoplastic; Diploidy; Karyotyping; Liver; Neoplasms, Experimental; Rats; Sarcoma; Time Factors | 1980 |
Morphological transformation of C3H/10T1/2 CL8 cells by procarcinogens.
Topics: 2-Acetylaminofluorene; 2-Naphthylamine; 4-Nitroquinoline-1-oxide; Aflatoxin B1; Aflatoxins; Animals; Benz(a)Anthracenes; Biotransformation; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Drug Evaluation, Preclinical; Embryo, Mammalian; Mice; Time Factors | 1982 |
Initiation of C3H/10T1/2 cell transformation by N-methyl-N'-nitro-N-nitrosoguanidine and aflatoxin B1.
Topics: Aflatoxin B1; Aflatoxins; Animals; Cell Line; Cell Transformation, Neoplastic; Methylcholanthrene; Methylnitronitrosoguanidine; Mice; Tetradecanoylphorbol Acetate | 1982 |
Malignant conversion of chemically transformed normal human cells.
Topics: Aflatoxin B1; Animals; Avian Sarcoma Viruses; Base Sequence; Blotting, Southern; Carcinogens; Carcinoma; Cell Adhesion; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Chromosome Mapping; Chromosomes, Human, Pair 7; DNA Primers; Epithelium; Gene Conversion; Humans; Infant, Newborn; Male; Methyl Methanesulfonate; Mice; Mice, Nude; Molecular Sequence Data; Polymerase Chain Reaction; Skin; Thiophenes; Transcription, Genetic; Transfection; Transplantation, Heterologous | 1996 |
Two-dimensional polyacrylamide gel electrophoresis of cancer-associated proteins.
Topics: Aflatoxin B1; Amino Acid Sequence; Animals; Autoradiography; Carcinogens; Cell Line, Transformed; Cell Transformation, Neoplastic; Electrophoresis, Polyacrylamide Gel; Epithelium; Female; Isoelectric Focusing; Liver; Molecular Sequence Data; Neoplasm Proteins; Oncogenes; Phosphoproteins; Phosphorus Radioisotopes; Rats; Rats, Inbred F344; Sequence Homology, Amino Acid; Tropomyosin | 1997 |
Predictive value of molecular dosimetry: individual versus group effects of oltipraz on aflatoxin-albumin adducts and risk of liver cancer.
Topics: Aflatoxin B1; Animals; Anticarcinogenic Agents; Biomarkers, Tumor; Carcinogens; Cell Transformation, Neoplastic; DNA Adducts; Dose-Response Relationship, Drug; Drug Administration Schedule; Liver Neoplasms, Experimental; Male; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes | 1997 |
Mutations associated with in vivo aflatoxin B1-induced carcinogenesis need not be present in the in vitro transformations by this toxin.
Topics: 3T3 Cells; Aflatoxin B1; Animals; Blotting, Southern; Carcinogenicity Tests; Cell Line; Cell Transformation, Neoplastic; DNA Mutational Analysis; Epithelial Cells; Genes, p53; Genes, ras; Liver; Male; Mice; Mice, Nude; Mutagens; Mutation; Rats; Rats, Inbred F344; Sequence Analysis, DNA; Transfection | 1999 |
[Transformation of rat hepatocytes in an in vitro primary culture by aflatoxin B1].
Topics: Aflatoxin B1; Animals; Animals, Newborn; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Cytochrome P-450 CYP1A2; Epithelial Cells; Genes, myc; Humans; Liver; Rats; Rats, Wistar; Transfection | 1997 |
Forging the links between metabolism and carcinogenesis.
Topics: Aflatoxin B1; Animals; Biotransformation; Carcinogens; Cell Transformation, Neoplastic; Cytochrome P-450 Enzyme System; DNA; DNA Adducts; DNA Damage; Genetic Predisposition to Disease; History, 20th Century; Humans; Isoenzymes; Microsomes, Liver; Molecular Biology; Mutagenesis; Neoplasms; Structure-Activity Relationship | 2001 |
Chemoprevention of aflatoxin B1-initiated and carbon tetrachloride-promoted hepatocarcinogenesis in the rat by green tea.
Topics: Aflatoxin B1; Animals; Carbon Tetrachloride; Cell Division; Cell Transformation, Neoplastic; Fibrosis; gamma-Glutamyltransferase; Glutathione Transferase; Immunohistochemistry; Lipid Peroxidation; Liver; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred F344; Tea | 2000 |
Cytokeratin expression during AFB1-induced carcinogenesis.
Topics: Aflatoxin B1; Aflatoxins; Animals; Antibodies, Monoclonal; Antibodies, Neoplasm; Cell Transformation, Neoplastic; Cross Reactions; Cytoskeleton; Intermediate Filaments; Keratins; Liver; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred F344; Tumor Cells, Cultured | 1990 |
Aflatoxin-transformed C3H/10T1/2 cells overexpress protein kinase C and have an altered response to phorbol ester treatments.
Topics: Aflatoxin B1; Animals; Arachidonic Acid; Blotting, Western; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Division; Cell Line; Cell Transformation, Neoplastic; Isoenzymes; Kinetics; Mice; Mice, Inbred C3H; Phorbol 12,13-Dibutyrate; Protein Kinase C; Receptors, Drug | 1992 |
Effect of long term feeding and withdrawal of aflatoxin B1 and ochratoxin A on kidney cell transformation in albino rats.
Topics: Administration, Oral; Aflatoxin B1; Animals; Carcinogens; Cell Transformation, Neoplastic; Kidney; Male; Ochratoxins; Rats; Rats, Inbred Strains | 1991 |
Altered benzo[a]pyrene metabolism in C3H/10T1/2 cells transformed by aflatoxin B1 or 3-methylcholanthrene.
Topics: Aflatoxin B1; Aflatoxins; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Cell Cycle; Cell Line; Cell Transformation, Neoplastic; DNA; DNA Adducts; gamma-Glutamyltransferase; Glucuronosyltransferase; Glutathione Transferase; Inactivation, Metabolic; Methylcholanthrene | 1990 |
Induction of aryl hydrocarbon hydroxylase and DNA adduct formation in parental and carcinogen transformed C3H/10T1/2 clone 8 cells by benzo[a]pyrene.
Topics: Aflatoxin B1; Aflatoxins; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; Clone Cells; Cytochrome P-450 Enzyme System; DNA; DNA Adducts; Enzyme Induction; Fibroblasts; Male; Mice; Phosphorus Radioisotopes; Rats; Rats, Inbred Strains | 1989 |
Dose-related inhibition of aflatoxin B1 induced hepatocarcinogenesis by the phenolic antioxidants, butylated hydroxyanisole and butylated hydroxytoluene.
Topics: Aflatoxin B1; Aflatoxins; Animals; Anisoles; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Cell Transformation, Neoplastic; Dimethyl Sulfoxide; gamma-Glutamyltransferase; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred F344 | 1986 |
A system for transformation of rat liver cells in vitro by acute treatment with aflatoxin.
Topics: Aflatoxin B1; Aflatoxins; Animals; Carcinogens; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; gamma-Glutamyltransferase; Liver; Methods; Mice; Mice, Nude; Rats | 1987 |
Morphometric and cytophotometric nuclear analysis of altered hepatocyte foci induced by N-nitrosomorpholine (NNM) and aflatoxin B1 (AFB1) in liver of Wistar rats.
Topics: Aflatoxin B1; Aflatoxins; Animals; Carcinogens; Cell Nucleus; Cell Transformation, Neoplastic; Liver; Liver Neoplasms, Experimental; Male; Nitrosamines; Precancerous Conditions; Rats; Rats, Inbred Strains | 1988 |
Dose dependency of aflatoxin B1 binding on human high molecular weight DNA in the activation of proto-oncogene.
Topics: Aflatoxin B1; Aflatoxins; Animals; Carcinogens; Cell Transformation, Neoplastic; DNA; DNA Restriction Enzymes; DNA-Directed DNA Polymerase; Dose-Response Relationship, Drug; Humans; Kinetics; Liver; Mice; Mice, Inbred Strains; Molecular Weight; Nucleic Acid Hybridization; Protein Biosynthesis; Proto-Oncogene Mas; Proto-Oncogenes | 1985 |
Expression of the c-Ha-ras and c-myc genes in aflatoxin B1-induced hepatocellular carcinomas.
Topics: Aflatoxin B1; Aflatoxins; Animals; Carcinogens; Cell Transformation, Neoplastic; DNA Restriction Enzymes; Gene Amplification; Liver Neoplasms, Experimental; Male; Nucleic Acid Hybridization; Oncogenes; Plasmids; Protein Biosynthesis; Rats; Rats, Inbred F344; Transcription, Genetic | 1986 |
Effects of 3-aminobenzamide on the induction of morphologic transformation by diverse compounds in Balb/3T3 cells in vitro.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzamides; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Clone Cells; Ethyl Methanesulfonate; Kinetics; Methylcholanthrene; Methylnitronitrosoguanidine; Mice; Mice, Inbred BALB C | 1986 |
Differential effects of transforming growth factor-beta on proliferation of normal and malignant rat liver epithelial cells in culture.
Topics: Aflatoxin B1; Aflatoxins; Animals; Cell Cycle; Cell Transformation, Neoplastic; Cells, Cultured; Epithelial Cells; Growth Inhibitors; Liver; Liver Neoplasms; Microscopy, Electron; Peptides; Rats; Transforming Growth Factors | 1986 |
Identification of an activated c-Ki-ras oncogene in rat liver tumors induced by aflatoxin B1.
Topics: Aflatoxin B1; Aflatoxins; Animals; Cell Line; Cell Transformation, Neoplastic; DNA, Neoplasm; Gene Expression Regulation; GTP-Binding Proteins; Liver Neoplasms; Mice; Proto-Oncogene Proteins; Proto-Oncogenes; Rats; Transfection | 1986 |
Characterization of c-Ki-ras oncogene alleles by direct sequencing of enzymatically amplified DNA from carcinogen-induced tumors.
Topics: Aflatoxin B1; Aflatoxins; Alleles; Animals; Base Sequence; Cell Line; Cell Transformation, Neoplastic; DNA, Neoplasm; Enzyme Induction; Fibroblasts; Liver Neoplasms, Experimental; Male; Mice; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Rats; Rats, Inbred F344 | 1987 |
Transformation related expression of glutathione-S-transferase P in rat liver cells.
Topics: Aflatoxin B1; Aflatoxins; Animals; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Cytosol; Enzyme Induction; Glutathione Transferase; Histocytochemistry; Isoenzymes; Liver; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred F344 | 1987 |
A method for the amplification of chemically induced transformation in C3H/10T1/2 clone 8 cells: its use as a potential screening assay.
Topics: 2-Naphthylamine; Aflatoxin B1; Aflatoxins; Animals; Biotransformation; Carcinogens; Cell Transformation, Neoplastic; Clone Cells; Diethylnitrosamine; Dimethylnitrosamine; Male; Methylcholanthrene; Methylnitronitrosoguanidine; Rats; Rats, Inbred F344 | 1987 |