aflatoxin b1 has been researched along with Carcinoma, Hepatocellular in 261 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (8.05) | 18.7374 |
| 1990's | 58 (22.22) | 18.2507 |
| 2000's | 81 (31.03) | 29.6817 |
| 2010's | 77 (29.50) | 24.3611 |
| 2020's | 24 (9.20) | 2.80 |
| Authors | Studies |
|---|---|
| Santella, RM; Shen, J; Siegel, A; Wu, HC | 1 |
| Kang, Q; Liang, X; Liu, Q; Wang, W; Wang, Z | 1 |
| Cao, D; Cao, W; Yang, K; Yu, P | 1 |
| Ali, FI; Ilyas, R; Khan, R; Mustufa, MA; Naqvi, SNUH; Zia, Z | 1 |
| Abdelrady, YA; Abo-Hiemad, HM; Mohamed, MA; Nassar, AY; Sayed, AM; Shatat, AR; Soliman, M | 1 |
| Alvarez, CS; Brochier, M; Dean, M; Groopman, J; Higson, H; Jones, K; Lajous, M; Lino-Silva, LS; McGlynn, KA; Melchor-Ruan, J; Mohar, A; Romero-Martínez, M; Santiago-Ruiz, L; Smith, JW; Villalpando, S; Wang, M; Wu, D; Xie, Y | 1 |
| D'Errico, A; Fornari, F; Giovannini, C; Gnudi, F; Gramantieri, L; Mandrioli, D; Piscaglia, F; Suzzi, F; Tovoli, F; Vasuri, F; Vornoli, A | 1 |
| Adesogan, A; Havelaar, A; Saha Turna, N; Wu, F | 1 |
| Chhonker, SK; Koiri, RK; Rawat, D | 2 |
| Civil, O; Şen, L | 1 |
| Abdo, A; Afihene, M; Cunha, L; Desalegn, H; Dusheiko, G; Jonas, E; Kassianides, C; Katsidzira, L; Kramvis, A; Lam, P; Lesi, OA; Micah, EA; Musabeyezu, E; Ndow, G; Nnabuchi, CV; Ocama, P; Okeke, E; Rwegasha, J; Shewaye, AB; Some, FF; Sonderup, MW; Spearman, CW; Tzeuton, C | 1 |
| Akriviadis, E; Chatziioannou, A; Chourmouzi, D; Dedes, I; Giannakopoulou, L; Kalogeropoulou, L; Liava, C; Moumtzouoglou, A; Papadopoulou, E; Potsi, S; Sinakos, E; Stergioulas, L | 1 |
| Clausen, N; Elgart, B; Foley, JF; Gerrish, K; Gladwell, W; Mav, D; Merrick, BA; Phadke, D; Shah, R; Tripodi, I; Weick, M | 1 |
| Andric, N; Fa Nedeljkovic, S; Milošević, N; Samardzija Nenadov, D; Škrbić, S; Stanic, B; Sukur, N | 1 |
| Fathy, SA; Ghareeb, DA; Hamdy, GM; Khedr, SM | 1 |
| Abdel-Mageed, W; Abdel-Rahman, MH; Ezzat, S; Kohla, M; Mosbeh, A; Sultan, MM | 1 |
| Jin, J; Kesari, S; Kouznetsova, VL; Tsigelny, IF | 1 |
| Liu, M; Tang, D; Wang, B; Wang, Z; Zhang, Z | 1 |
| Fu, W; He, L; Huang, Y; Luo, J; Lv, C; Qiu, Z; Shu, W; Tan, Y; Wang, J; Wang, L; Zeng, H; Zheng, C | 1 |
| Bielenberg, DR; Deng, J; Fishbein, A; Gartung, A; Hallisey, VM; Hammock, BD; Huang, S; Hwang, SH; Kieran, MW; Panigrahy, D; Verheul, SML; Wang, W; Wang, Y; Yang, H; Yang, J | 1 |
| Chhonker, SK; Koiri, RK; Naik, RA; Rawat, D | 1 |
| Cvelbar, U; Filipič, M; Hojnik, N; Javornik, U; Modic, M; Plavec, J; Walsh, JL; Žegura, B; Žigon, D | 1 |
| He, K; Liu, F; Wang, H; Wang, S; Wang, X; Yang, X; Zhang, X | 1 |
| Cai, J; He, H; Jiao, Y; Li, M; Liang, J; Liu, M; Ma, Y; Qu, C; Wang, X; Wei, Z; Zeng, Y; Zhang, Y; Zhu, Q | 1 |
| Chen, JA; Feng, X; He, L; Huang, Y; Lin, H; Liu, W; Luo, J; Luo, Y; Pu, C; Qiu, Z; Shu, W; Tan, Y; Tian, Y; Wang, J; Wang, L; Wu, L; Xiao, G; Yang, X; Zeng, H; Zhang, R; Zheng, C | 1 |
| Abedi-Ardekani, B; Ardin, M; Boot, A; Heguy, A; Hollstein, M; Huang, MN; Jusakul, A; Myint, SS; Ng, AWT; Olivier, M; Othman, R; Poon, SL; Rozen, SG; Sabapathy, K; Tan, P; Teh, BT; Teoh, WW; Villar, S; Yu, W; Zavadil, J | 1 |
| Li, LQ; Ma, L; Qi, LN; Qin, HG; Wang, YY; Xiang, BD; Xiang, X; You, XM; Zhong, JH | 1 |
| He, L; Li, D; Liu, L; Liu, W; Shu, W; Tan, Y; Wang, J; Wang, L; Zhao, X; Zheng, C | 1 |
| Maurya, BK; Trigun, SK | 2 |
| Becker, RA; Moore, MM; Pottenger, LH; Schoeny, RS; White, K | 1 |
| Amougou Atsama, M; Atangana, PJA; Bekondi, C; Béré, A; Camengo-Police, SM; Komas, NP; Marchio, A; Njouom, R; Noah Noah, D; Pineau, P | 1 |
| Chen, XP; Chen, Y; Liu, KC; Mo, PL; Wang, J; Wei, YJ; Zhang, L; Zhang, ZG; Zhang, ZW | 1 |
| Amorim, RP; Cardoso, MV; de Souza Furtado, KM; Espíndola, KMM; Ferreira, RG; Monteiro, MC | 1 |
| Rushing, BR; Selim, MI | 1 |
| Engin, A; Engin, AB | 1 |
| Gao, Y; Wang, C; Xiao, P; Xu, H; Zhang, Y | 1 |
| Li, R; Liang, X; Liu, M; Su, M; Zhou, R | 1 |
| Jin, SL; Lin, YM; Lu, JW; Yang, WY; Yuh, CH | 1 |
| Auerbach, SS; Mav, D; Merrick, BA; Phadke, DP; Shah, RR; Stiegelmeyer, SM; Tice, RR | 1 |
| Huang, XY; Liu, M; Long, XD; Ma, Y; Mo, XQ; Wang, C; Wei, ZH; Xia, Q; Xue, F; Yao, JG; Zeng, LX; Zhai, B; Zhang, JJ; Zhao, D | 1 |
| Dejean, A; Generalov, MI; Granov, DA; Kalinina, O; Marchio, A; Pineau, P; Rebbani, K; Tarkova, AB; Urbanskii, AI | 1 |
| Chaudhary, H; Jena, PK; Seshadri, S | 1 |
| Chen, CJ; Santella, RM; Tsai, WY; Wang, Q; Wu, HC; Yang, HI | 1 |
| Dhanda, S; Moudgil, V; Redhu, D; Singh, J | 1 |
| Chen, Z; Ji, J; Li, J; Wang, H; Yang, L | 1 |
| Bai, T; Chen, YY; Chen, ZH; Han, ZG; Li, LQ; Li, S; Liu, TW; Liu, ZM; Mo, ZN; O'Brien, SJ; Peng, MH; Peng, T; Qi, LN; Qin, X; Santella, RM; Winkler, CA; Xiang, BD; Xiao, KY | 1 |
| Burgers, PM; Li, L; Lin, YC; Lloyd, RS; Makarova, AV; Stone, MP | 2 |
| Chen, S; Ding, ZB; Fan, J; Huang, XW; Peng, YF; Qiu, SJ; Ren, N; Shen, YH; Shi, YH; Yang, GH; Yi, Y; Zhou, J | 1 |
| Bai, T; Chen, YY; Chen, ZS; De Xiang, B; Han, ZG; Li, LQ; Peng, T; Qi, LN; Wu, FX | 1 |
| Feng, Y; Guo, Z; Lian, J; Srinivas, S; Wang, S; Yang, W; Zhong, H; Zhuang, Z | 1 |
| Baxter, VK; Egner, PA; Groopman, JD; Johnson, NM; Kensler, TW; Roebuck, BD; Sporn, MB; Sutter, TR; Wible, RS | 1 |
| Li, SQ; Luo, L; Lv, J; Wang, Q; Yu, YQ | 1 |
| Huang, XY; Liu, YX; Long, XD; Ma, Y; Wang, C; Xi, ZF; Xia, Q; Xing, TY; Yao, JG | 1 |
| Olden, K; Vulimiri, SV | 1 |
| Eaton, DL; Schaupp, CM | 1 |
| Chen, J; He, K; Lai, H; Lin, Y; Liu, C; Mo, X; Xiao, J; Yang, Y | 1 |
| Nault, JC | 1 |
| Huang, XY; Long, XD; Yao, JG | 1 |
| De Meulenaer, B; De Saeger, S; Jacxsens, L; Kolsteren, P; Lachat, C; Walpita, CN; Yogendrarajah, P | 1 |
| Goh, LK; Sabapathy, K; Teoh, WW; Tong, WM; Vijayaraghavan, A; Xie, M; Yaligar, J | 1 |
| Huang, XY; Liao, P; Long, XD; Ma, Y; Tang, YJ; Xia, Q; Yao, JG | 1 |
| Asiki, G; Kaleebu, P; Kang, MS; Lutalo, T; Muwanika, R; Nalugoda, F; Newton, R; Nkurunziza, P; Nkwata, A; Qian, G; Seeley, J; Serwadda, D; Song, X; Ssempebwa, J; Tang, L; Wang, JS; William, JH; Xue, K | 1 |
| Gao, J; Huang, K; Luo, Y; Xu, W; Zhang, B; Zhu, L | 1 |
| Huang, BC; Huang, XY; Long, XD; Ma, Y; Xia, Q; Yao, JG | 1 |
| Arumugam, P; Ju, H; Shim, Y; Song, JM | 1 |
| Bekers, O; Claessen, SM; de Kok, TM; Jennen, DG; Kleinjans, JC; Rieswijk, L; Theunissen, DH; van Breda, SG; van Herwijnen, M | 1 |
| Gores, G; Llovet, JM; Pikarsky, E; Sangro, B; Schwartz, M; Sherman, M; Zucman-Rossi, J | 1 |
| Fu, R; Wang, S; Yang, C; Zhuang, Z | 1 |
| Bai, XC; Chen, KH; Chen, ZX; Gao, T; Jia, CH; Lan, J; Pan, D; Pan, JF; Wei, HM | 1 |
| He, J; Jiang, C; Lin, J; Ou, C; Shi, J; Sun, F; Sun, X | 1 |
| Amin, S; Choi, B; Desai, D; Hu, Y; Lee, HW; Mehta, M; Tang, MS; Wang, HT; Weng, MW; Zheng, Y | 1 |
| Deng, ZL; Huang, YZ; Long, XD; Ma, Y; Wei, NB | 1 |
| Gong, YY; Groopman, JD; Kieszak, SM; McCoy, LF; Powers, CD; Rogers, HS; Schleicher, RL; Scholl, PF; Sutcliffe, AE; Wild, CP | 1 |
| Chen, SY; Chen, YM; Chou, TY; Darbha, R; Hsieh, LL; Hung, JH; Liu, HH; Liu, SP; Tsai, TF; Ueng, YF; Yen, CH | 1 |
| Fabregat, I | 1 |
| Ahsan, H; Chen, CJ; Chen, SY; Santella, RM; Tsai, WY; Wang, LY; Wang, Q; Wu, HC; Yang, HI | 2 |
| Li, FQ; Li, YW; Luo, XY; Wang, YR | 1 |
| Luka, Z; Mato, JM; Wagner, C | 1 |
| Ji, L; Yu, H | 1 |
| Gasbarrini, A; Pani, G; Petersen, BE; Piscaglia, AC; Shupe, TD; Tesori, V | 1 |
| Besaratinia, A; Hainaut, P; Kim, SI; Pfeifer, GP | 1 |
| Aguilar-Melero, P; Barrera, P; Bello, RI; de la Mata, M; Ferrín, G; González, R; González-Rubio, S; Hidalgo, AB; Linares, CI; Marchal, T; Muntané, J; Nakayama, KI; Ranchal, I | 1 |
| Crawford, D; Egner, PA; Ilic, Z; Sell, S; Vakharia, D | 1 |
| Ban, FZ; Huang, BC; Huang, YZ; Long, XD; Ma, Y; Yao, JG; Zhou, YF | 1 |
| Angeli, JP; Barbosa, F; Barcelos, GR; Mantovani, MS; Nersesyan, A; Serpeloni, JM | 1 |
| Drouin, R; Lacoste, S; Rochette, PJ | 1 |
| Kew, MC | 2 |
| Chen, YM; Chien, CH; Huang, SF; Lee, CM; Li, YS; Liao, YJ; Liu, SP; Yen, CH | 1 |
| Abedi-Ardekani, B; Caron de Fromentel, C; Chemin, IA; Egevad, LA; Galy, O; Gouas, DA; Hainaut, PL; Hantz, O; Hautefeuille, AH; Legros, PC; Ortiz-Cuaran, SL; Shi, H; Szymanska, KJ; Wiman, KG | 1 |
| Abdou, E; Boismenu, D; Hamel, N; Kearney, RE; Laboissière, S; Lanoix, J; Paiement, J; Roy, L; Taheri, M; Thibault, G | 1 |
| Choi, KC; Chung, WT; Jang, YS; Kwon, JK; Lee, JC; Lee, SY; Park, SM; Yu, JY | 1 |
| Qian, G; Su, J; Tang, L; Wang, JS; Xu, L | 1 |
| Fu, GH; Long, XD; Ma, AM; Ma, Y; Zhou, YF | 1 |
| Azeez, OI; Oyagbemi, AA; Saba, AB | 1 |
| Cunningham, K; Donnelly, KC; Guerra, F; Johnson, NM; Kaufman, L; Marroquin-Cardona, A; Phillips, TD; Qian, G; Robinson, A; Rodriguez, M; Tietze, D; Wang, JS; Williams, JH; Wittmer, J; Xu, L | 1 |
| Akano, A; Bah, E; Hainaut, P; Kirk, GD; Lesi, OA; Mendy, M; Umoh, NJ; Whittle, H | 1 |
| Gursoy-Yuzugullu, O; Ozturk, M; Yilmaz, M; Yuzugullu, H | 1 |
| Belanger, CL; Bouhenguel, JT; Croy, RG; Egner, PA; Essigmann, JM; Groopman, JD; Trudel, LJ; Wattanawaraporn, R; Wogan, GN; Woo, LL | 1 |
| Callegari, E; Elamin, BK; Gramantieri, L; Negrini, M; Sabbioni, S | 1 |
| Egashira, A; Harimoto, N; Kajiyama, K; Maehara, Y; Shirabe, K; Taguchi, K; Taketomi, A; Toshima, T; Uchiyama, H; Yoshizumi, T | 1 |
| Asim, M; Kar, P; Sarma, MP; Thayumanavan, L | 1 |
| Aggarwal, PK; Behare, PV; Gautam, SK; Grover, CR; Kumar, A; Kumar, M; Nagpal, R; Verma, V | 1 |
| Feng, Y; Huang, H; Li, HX; Li, P; Mao, QS; Rui, L; Sha, ZY; Xue, WJ | 1 |
| El-Serag, HB | 1 |
| Ding, C; Qin, H; Yu, H | 1 |
| Bah, E; Chemin, I; Ferro, G; Friesen, MD; Gouas, DA; Groopman, J; Hainaut, P; Kirk, GD; Legros, P; Lesi, OA; Mendy, M; Ortiz-Cuaran, S; Villar, S | 1 |
| Hua, H; Jiang, Y; Kong, Q; Luo, T; Ma, Y | 1 |
| Asim, M; Kar, P; Sarma, MP | 1 |
| Chen, J; Chen, T; Gail, MH; Hsia, CC; Huang, F; Liu, G; Lu, J; Lu, L; Lu, P; Ni, Z; Park, JH; Qu, C; Sun, Z; Thorgeirsson, SS; Wang, N; Wu, Y; Wu, Z; Xu, L; Zhan, Q; Zhang, Q; Zhu, Y | 1 |
| Huang, XY; Liu, M; Long, XD; Ma, Y; Wei, ZH; Xia, Q; Xue, F; Yao, JG; Zeng, Z; Zhai, B; Zhang, JJ | 1 |
| Ahsan, H; Chen, CJ; Chen, SY; Chen, Y; Lee, PH; Lunn, RM; Santella, RM; Wang, LY; Zhang, YJ | 1 |
| Groopman, JD; He, X; Jackson, PE; Kuang, SY; Qian, GS | 1 |
| Finegold, MJ; Madden, CR; Slagle, BL | 1 |
| Chen, CJ; Santella, RM; Sun, CA; Wang, LY; Wu, DM; You, SL | 1 |
| Ahsan, H; Chen, CJ; Chen, Y; Lee, PH; Lunn, RM; Santella, RM; Zhang, YJ | 1 |
| Chen, GC; Cheng, G; Harada, K; Huang, XE; Koide, T; Mizokami, M; Oda, H; Ohno, T; Sueoka, E; Tashiro, F; Tokudome, S; Ueno, Y; Xiang, J; Yu, SZ | 1 |
| Jun, HS; Kim, SE; Sung, MK | 1 |
| Ban, KC; Duan, XX; Li, Y; Li, YY; Ou, C; Qin, LL; Su, JJ; Wang, HY; Yan, RQ; Yang, C | 1 |
| Buetow, KH; Evans, AA; Hunter, K; LeVoyer, T; London, WT; McGlynn, KA; Michielli, RA; Roush, J; Shen, FM; Wise, P | 1 |
| Ban, KC; Cao, J; Gu, JR; Li, Y; Ou, C; Ou, SJ; Qiu, XK; Su, JJ; Wan, DF; Wei, W; Yang, C; Yue, HF; Zhang, LS | 1 |
| Ban, KC; Cao, J; Gu, JR; Li, Y; Luo, D; Ou, C; Qin, LL; Qiu, XK; Su, JJ; Wan, DF; Yang, C; Yue, HF; Zhang, LS | 1 |
| Sell, S; Shupe, T | 1 |
| Nayak, NC | 1 |
| Chen Ban, K; Fong Seow, H; Krishnan, R; Singh, H | 1 |
| Farmer, PB; Sharma, RA | 1 |
| Cecere, A; Gattoni, A; Marotta, F; Vangieri, B | 1 |
| Brockmöller, J; Hustert, E; Kirk, G; Mendy, M; Pedersen, B; Turner, PC; Whittle, HC; Wild, CP; Wojnowski, L | 1 |
| Ahsan, H; Chen, CJ; Chen, SY; Chen, Y; Lee, PH; Lunn, RM; Santella, RM; Zhang, YJ | 1 |
| Choon-Nam, O; Han-Ming, S; Le-Qun, L; Lian-Wen, W; Lu-Nam, Y; Min-Hao, P; Qiao, W; Ren-Xiang, L; Santella, RM; Tang-Wei, L; Tao, P; Xue, Q; Zhi-Ming, L; Zong-Liang, W | 1 |
| Xue, KX | 1 |
| Choi, EH; Chun, HS; Lee, JK; Lee, KG | 1 |
| Bailey, GS; Bayne, CJ; Corley-Smith, G; Gerwick, LG; Givan, SA; Hendricks, JD; Rosato, CS; Tilton, SC; Williams, DE | 1 |
| Deng, ZL; Long, XD; Ma, Y; Wei, YP | 2 |
| Aninat, C; Glaise, D; Guguen-Guillouzo, C; Guillouzo, A; Langouët, S; Le Charpentier, T; Morel, F; Piton, A | 1 |
| Gormally, E; Hainaut, P; Le Roux, E | 1 |
| Billam, M; Kendall, RJ; McKean, C; Tang, L; Tang, M; Theodorakis, CW; Wang, JS; Wang, Z | 1 |
| Agrawal, M; Ahsan, H; Chen, Y; Lee, PH; Rossner, P; Santella, RM; Wang, L; Wang, Q; Yu, MW; Zhang, YJ | 1 |
| Belloir, C; Daurat, C; Le Bon, AM; Siess, MH; Singh, V | 1 |
| Abdel-Hadi, AA; Abu Zikri, NB; El-Ansary, M; El-Raai, A; El-Shanawani, FM; Ismail, A | 1 |
| El-Nezami, HS; Juvonen, RO; Ling, W; Ma, J; Mykkänen, HM; Polychronaki, NN; Poussa, T; Salminen, EK; Salminen, SJ; Zhu, H | 1 |
| Dixon, KR; Lian, M; Liu, Y; Qian, GS; Wan, SG; Yu, SZ | 1 |
| Han, EH; Jeong, HG; Kang, KW; Kim, JY; Kim, SK; Oh, SJ; Pokharel, YR; Woo, ER | 1 |
| Awad, AT; Habib, SL; Mostafa, MH; Said, B; Shank, RC | 1 |
| Ahsan, H; Chen, CJ; Chen, SY; Santella, RM; Tsai, WY; Wang, LW; Wang, LY; Wang, Q; Wu, HC; Yang, HI | 1 |
| Li, LQ; Liang, RX; Liu, TW; Liu, ZM; Ong, CN; Peng, MH; Peng, T; Santella, RM; Shen, HM; Wang, KB; Wang, L; Wang, Q; Wei, ZL; Yan, LN | 1 |
| DePinho, RA; Farazi, PA | 1 |
| Aninat, C; Corlu, A; Glaise, D; Guguen-Guillouzo, C; Guillouzo, A; Morel, F | 1 |
| Bailey, GS; Hendricks, JD; Orner, GA; Pereira, CB; Tilton, SC; Williams, DE | 1 |
| Harris, CC; Hussain, SP; Schwank, J; Staib, F; Wang, XW | 1 |
| Feng, XL; Feng, ZB; Lu, HX | 1 |
| Ban, KC; Cao, J; Chen, MW; Jiao, Y; Su, JJ; Yue, HY | 1 |
| Jayanthi, V; Mathews, S; Murali, A; Murugavel, KG; Naranatt, PP; Palaniswamy, KR; Raghuram, K; Rajasambandam, P; Shankar, EM; Srikumari, D; Srinivas, U; Surendran, R; Thyagarajan, SP | 1 |
| Egner, P; Fasullo, M; Sun, M | 1 |
| Sachdanandam, P; Shanthi, P; Umarani, M | 1 |
| Guo, Y; Li, LQ; Li, S; Liang, RX; Liu, TW; Liu, ZM; Mo, XS; Ong, CN; Peng, MH; Peng, T; Qin, X; Qin, Z; Santella, RM; Shen, HM; Wang, KB; Wang, L; Wang, Q; Wei, ZL; Xiao, KY; Yan, LN; Ye, XP | 1 |
| Cao, J; Cui, J; Dai, Z; Duan, X; Kang, X; Li, Y; Liu, Y; Ou, C; Qin, X; Su, J; Yang, C; Yue, H; Zhang, Y | 1 |
| Begum, VH; Sivanesan, D | 1 |
| Su, H; Xiong, Y; Xu, T; Yuan, Y; Zhang, Y; Zhao, J; Zhou, F; Zhuang, SM | 1 |
| Battiston, C; Cordina, E; Dejean, A; Marchio, A; Mazzaferro, V; Pineau, P; Qin, LX; Russo, A; Tang, ZY; Terris, B; Turlin, B | 1 |
| Huang, YZ; Huang, ZQ; Lin, ZH; Liu, YG; Long, XD; Ma, Y; Qu, DY; Wei, NB; Zhou, SC | 1 |
| Kanisawa, M | 1 |
| Ding, ZR | 1 |
| Garner, JV; Garner, RC; Martin, CN; Montesano, R; Ryder, RW; Sizaret, P; Tursi, F; Whittle, HC | 1 |
| Enwonwu, CO | 1 |
| Lambiotte, M; Thierry, N | 1 |
| Hayes, AW; Hogan, GR; Ryan, NJ; Siraj, MY; Unger, PD; Wray, BB | 1 |
| Bréchot, C; Castaing, D; Franco, D; Morin, J | 1 |
| Lindsay, DG; Watson, DH | 1 |
| Ogbadu, GH; Onyemelukwe, GC; Salifu, A | 1 |
| Huh, N; Nemoto, N; Utakoji, T | 1 |
| Abe, S; Nemoto, N; Sasaki, M | 1 |
| Dutton, MF; McLean, M | 1 |
| Liang, TJ | 1 |
| Lee, HP; Li, B; Lin, Y; Ong, CN; Phang, TW; Shi, CY; Wee, A | 1 |
| Ghebranious, N; Knoll, BJ; Lozano, G; Sell, S; Wu, H | 1 |
| Bloodworth, BC; Chao, TC; Gunasegaram, R; Koh, TH; Lo, DS; Ng, HS | 1 |
| Ozturk, M | 1 |
| Blum, HE | 1 |
| Baffoe-Bonnie, A; Clapper, ML; Hu, Y; Lustbader, ED; McGlynn, KA; Ofori-Adjei, D; Rosvold, EA; Wild, CP; Xia, XL; Zhou, T | 1 |
| Aguilar, F; Cerutti, P; Hussain, P; Pourzand, C | 1 |
| Cullen, JM; Marion, PL; Rivkina, MB; Robinson, WS | 1 |
| Sun, WM; Yu, S; Zhao, N | 1 |
| Heck, R; Jennings, GS; Oesch, F; Steinberg, P | 1 |
| Murakami, Y | 1 |
| Aguilar, F; Cerutti, P; Harris, CC; Hollstein, M; Sun, T | 1 |
| Cova, L; Duflot, A; Prave, M; Trepo, C | 1 |
| Cao, SF; Chutimataewin, S; Cova, L; Duflot, A; Mehrotra, R; Montesano, R; Prave, M; Trepo, C; Wild, CP; Yu, SZ | 1 |
| Bleicher, F; Chutimataewin, S; Harris, CC; Hollstein, MC; Montesano, R; Srivatanakul, P; Wild, CP | 1 |
| Chen, ZY; Eaton, DL; Hulla, JE | 1 |
| Cao, Y; Gu, JR; He, L; Li, D; Wang, NJ | 1 |
| Hsieh, LL; Hsieh, TT | 1 |
| Cova, L; Jansen, LA; Montesano, R; Wild, CP | 1 |
| Chen, CJ; Feitelson, M; Haghighi, B; Hsieh, LL; Lee, CS; Santella, RM; Wang, LW; Yang, GY; Zhang, YJ | 1 |
| Aguilar, F; Cerutti, P; Hussain, SP | 1 |
| Lanoix, J; Paiement, J | 1 |
| Bruijntjes-Rozier, GC; Evertz, SJ; Rompelberg, CJ; van den Heuvel, PD; Verhagen, H | 1 |
| Bennett, WP; Bergasa, NV; Calderon, IE; Cawley, H; Chia, SC; DeBenedetti, VM; DiBisceglie, AM; Groopman, JD; Hansen, C; Harris, CC; Jones, EA; Munoz Espinosa, LE; Sandoval, CA; Soini, Y; Trivers, GE; Wang, JS; Welsh, JA | 1 |
| Bailey, EA; Essigmann, JM; Harris, TM; Iyer, RS; Stone, MP | 1 |
| Bell, DA; Chen, CJ; Chiamprasert, S; Hirvonen, A; Liaw, YF; Matin, F; Santella, RM; Wang, LW; Yu, MW | 1 |
| Yap, I | 1 |
| Soussi, T | 1 |
| Chen, CJ; Liaw, YF; Lien, JP; Yu, MW | 1 |
| Buetow, K; Clapper, M; Evans, AA; Litwin, S; London, WT; McGlynn, K; Ross, E; Shen, FM; Wild, C; Zhou, T | 1 |
| Groopman, JD; Scholl, P; Wang, JS | 1 |
| Ong, CN; Shen, HM | 1 |
| Cote, PJ; Marion, PL; Rivkina, M; Robinson, WS; Tennant, BC | 1 |
| Chen, CJ; Lee, CS; Lee, PH; Lunn, RM; Santella, RM; Tsai, WY; Wang, LY; Zhang, YJ | 1 |
| Essigmann, JM; Kobertz, WR; Wang, D; Wogan, GN | 1 |
| Premalatha, B; Sachdanandam, P; Sujatha, V | 1 |
| Peng, W; Yao, J; Zhou, Y | 1 |
| de Oliveira, CA; Germano, PM | 1 |
| Denissenko, MF; Koudriakova, TB; O'Connor, TR; Pfeifer, GP; Riggs, AD; Smith, L | 1 |
| Han, F; Ishikawa, T; Oda, H; Shimizu, Y; Zhu, JJ | 1 |
| Premalatha, B; Sachdanandam, P | 1 |
| Chao, HK; Lin, CS; Su, TS; Tsai, TF | 1 |
| Greenblatt, MS; Groopman, JD; Hoque, A; Patt, YZ; Santella, RM; Yoffe, B; Zhang, YJ | 1 |
| Deng, Z; Ma, Y; Pan, L | 1 |
| Ban, KC; Lee, EH; Lee, YI; Park, US; Qin, L; Su, JJ | 1 |
| Das, GC; Lee, S; Lee, YI; Park, SM; Park, US | 1 |
| Blum, HE; Moradpour, D | 1 |
| Bailey, EA; Currier, SS; Essigmann, JM; Smela, ME | 1 |
| London, SJ; Stern, MC; Taylor, JA; Umbach, DM; Yu, MC; Zhang, ZQ | 1 |
| Das, BC; Guptan, RC; Malhotra, V; Saigal, S; Sarin, SK; Thakur, V; Thyagarajan, SP | 1 |
| Devereux, TR; Flake, GP; London, SJ; Stern, MC; Taylor, JA; Yu, MC; Zhang, ZQ | 1 |
| Kawamura, O; Li, FQ; Li, YW; Luo, XY; Yoshizawa, T | 1 |
| Ahsan, H; Chen, CJ; Chen, SY; Lin, JT; Liu, TY; Santella, RM; Tsai, WY | 1 |
| Balabaud, C; Bayer, J; Capron, F; Degott, C; Gressin, L; Legoix, P; Tubacher, E; Vaury, C; Yakicier, MC; Zucman-Rossi, J | 1 |
| Devesa, SS; Fraumeni, JF; Hsing, AW; McGlynn, KA; Tsao, L | 1 |
| Bailey, GS; Egner, PA; Gange, SJ; Groopman, JD; Helzlsouer, KJ; Jacobson, LP; Kensler, TW; Kuang, SY; Qian, GS; Wang, JB; Wu, Y; Zhang, BC; Zhang, QN; Zhu, YR | 1 |
| Itsubo, M; Saito, A; Toda, G | 1 |
| Yu, S; Zhao, N; Zi, X | 1 |
| Jiang, W; Lu, Q; Pan, G | 1 |
| Essigmann, JM; Hamm, ML; Harris, CM; Harris, TM; Henderson, PT; Smela, ME | 1 |
| Castagnetta, LA; Cervello, M; Dantona, F; Giannitrapani, L; Montalto, G; Terranova, A | 1 |
| Wogan, GN | 1 |
| Kolars, JC | 1 |
| Akao, M; Gonoi, T; Kishikawa, S; Kuroda, K | 1 |
| Thomas, D; Wu-Williams, AH; Zeise, L | 1 |
| Chen, CJ; Lu, SN; Santella, RM; Zhang, YJ | 1 |
| Duimstra, JR; Hendricks, JD; Nunez, O | 1 |
| Chen, CJ; Feitelson, M; Haghighi, B; Lee, CS; Santella, R; Wang, LW; Yang, GY; Zhang, YJ | 1 |
| Cullen, JM; Hong, X; Marion, PL; Newbold, JE; Sherman, GJ | 1 |
| Li, DR; Li, YD; Liu, ZH; Qin, BB; Tu, WS; Xie, CH; Yang, YZ | 1 |
| Aoyama, T; Gelboin, HV; Gonzalez, FJ; Guzelian, PS; Yamano, S | 1 |
| Best, SJ; Cameron, RG; Crane, TL; Farber, E; Hayes, MA; Kocal, TE; Quinn, BA; Rushmore, TH | 1 |
| Tabor, E | 1 |
| Henderson, BE; Luo, S; Mo, CC; Tong, MJ; Yeh, FS; Yu, MC | 1 |
| Lee, HS; Sarosi, I; Vyas, GN | 1 |
| Dvorackova, I; Garner, RC; Tursi, F | 1 |
| Mo, CC; Yeh, FS; Yen, RC | 1 |
| Blum, HE; Busch, MP; Rajagopalan, MS; Vyas, GN | 1 |
| Dvorackova, I; Stora, C | 2 |
| Autrup, H; Seremet, T; Wakhisi, J; Wasunna, A | 1 |
| Harris, CC; Sun, TT | 1 |
47 review(s) available for aflatoxin b1 and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Aflatoxin B1: metabolism, toxicology, and its involvement in oxidative stress and cancer development.
Topics: Aflatoxin B1; Aflatoxins; Animals; Carcinoma, Hepatocellular; DNA; Humans; Liver Neoplasms; Oxidative Stress | 2022 |
Hepatocellular carcinoma: measures to improve the outlook in sub-Saharan Africa.
Topics: Aflatoxin B1; Africa South of the Sahara; Carcinoma, Hepatocellular; Hepatitis C; Humans; Liver Neoplasms | 2022 |
Liver Imaging Reporting and Data System criteria for the diagnosis of hepatocellular carcinoma in clinical practice: A pictorial minireview.
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; Contrast Media; Humans; Liver Neoplasms; Magnetic Resonance Imaging; Retrospective Studies; Sensitivity and Specificity | 2022 |
Synergism in actions of HBV with aflatoxin in cancer development.
Topics: Aflatoxin B1; Aflatoxins; Animals; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Neoplasms | 2023 |
Development of an adverse outcome pathway for chemically induced hepatocellular carcinoma: case study of AFB1, a human carcinogen with a mutagenic mode of action.
Topics: Adverse Outcome Pathways; Aflatoxin B1; Animals; Carcinogens; Carcinoma, Hepatocellular; DNA Adducts; Humans; Liver Neoplasms; Mutagens; Mutation | 2018 |
Epigenetic alterations caused by aflatoxin b1: a public health risk in the induction of hepatocellular carcinoma.
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; DNA Methylation; Epigenesis, Genetic; Histones; Humans; Liver Neoplasms; MicroRNAs; Protein Biosynthesis; Public Health; Risk; RNA, Long Noncoding | 2019 |
Aflatoxin B1: A review on metabolism, toxicity, occurrence in food, occupational exposure, and detoxification methods.
Topics: Aflatoxin B1; Animals; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Cytochrome P-450 Enzyme System; Decontamination; DNA Adducts; Food Contamination; Gamma Rays; Growth Disorders; Humans; Immunologic Factors; Liver Neoplasms; Malnutrition; Occupational Exposure | 2019 |
DNA damage checkpoint response to aflatoxin B1.
Topics: Aflatoxin B1; Animals; Ataxia Telangiectasia Mutated Proteins; Carcinogenesis; Carcinoma, Hepatocellular; DNA Damage; Humans; Liver Neoplasms; Oxidative Stress; Receptors, Death Domain | 2019 |
Hepatocellular carcinoma in the noncirrhotic liver: a literature review.
Topics: Aflatoxin B1; Age Distribution; Alcohol Drinking; beta Catenin; Carcinogenesis; Carcinoma, Hepatocellular; Cyclin-Dependent Kinase Inhibitor p21; DNA Methylation; Environmental Exposure; Food Contamination; Genes, Tumor Suppressor; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Liver Neoplasms; Non-alcoholic Fatty Liver Disease; Oncogene Proteins; Prognosis | 2019 |
A review of molecular mechanisms in the development of hepatocellular carcinoma by aflatoxin and hepatitis B and C viruses.
Topics: Aflatoxin B1; Animals; Carcinoma, Hepatocellular; DNA Adducts; Hepacivirus; Hepatitis B virus; Humans; Lipid Peroxidation; Liver Neoplasms; Mutation; Tumor Suppressor Protein p53 | 2013 |
Quantitative assessment of the effect of glutathione S-transferase genes GSTM1 and GSTT1 on hepatocellular carcinoma risk.
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; Epistasis, Genetic; Genetic Predisposition to Disease; Genotype; Glutathione Transferase; Humans; Liver Neoplasms; Polymorphism, Genetic; Risk; Serum Albumin | 2014 |
Pathogenesis of hepatocellular carcinoma according to aetiology.
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; Hepatitis B; Hepatitis C; Humans; Liver Cirrhosis; Liver Neoplasms; Mutagenesis, Insertional; Point Mutation; Risk Factors; Tumor Suppressor Protein p53 | 2014 |
Hepatocellular carcinoma.
Topics: Aflatoxin B1; Alcohol Drinking; Carcinoma, Hepatocellular; Fibrosis; Hepatitis B; Hepatitis B Vaccines; Hepatitis C; Humans; Hypoglycemic Agents; Life Style; Metformin; Risk Factors | 2016 |
Dysregulation of apoptosis in hepatocellular carcinoma cells.
Topics: Aflatoxin B1; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Death; Cell Division; Cell Survival; Gene Expression Regulation, Neoplastic; Humans; Inflammation; Kinetics; Liver Neoplasms; Mice; Mice, Transgenic; Receptors, Death Domain; Transforming Growth Factor beta; Tumor Suppressor Protein p53 | 2009 |
[Relationship of single nucleotide polymorphism, environmental factors and the hereditary susceptibility of hepatocellular carcinoma].
Topics: Aflatoxin B1; Animals; Carcinoma, Hepatocellular; Genetic Predisposition to Disease; Hepatitis B, Chronic; Humans; Liver Neoplasms; Polymorphism, Single Nucleotide | 2009 |
[Mapping DNA damage to understand somatic mutagenesis].
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aflatoxin B1; Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Codon; DNA; DNA Damage; DNA Methylation; DNA Repair; Genes, p53; Humans; Liver Neoplasms; Lung Neoplasms; Mutagenesis; Neoplasms, Radiation-Induced; Polymerase Chain Reaction; Skin Neoplasms; Sunlight; Ultraviolet Rays | 2010 |
MicroRNA response to environmental mutagens in liver.
Topics: Aflatoxin B1; Animals; Arsenic; Benzo(a)pyrene; Carcinoma, Hepatocellular; Environmental Pollutants; Ethanol; Gene Expression Regulation; Hepacivirus; Hepatitis B virus; Humans; Liver; Liver Neoplasms; MicroRNAs; Mutagens; Nicotiana; Poisons; Risk Factors; Rodenticides; Triazines | 2011 |
Epidemiology of viral hepatitis and hepatocellular carcinoma.
Topics: Aflatoxin B1; Biomarkers; Carcinoma, Hepatocellular; Coinfection; Cost of Illness; DNA, Viral; Epidemiologic Studies; Genotype; Global Health; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Incidence; Liver Cirrhosis; Liver Neoplasms; Meta-Analysis as Topic; Prevalence; Risk Assessment; Risk Factors; United States; Virus Replication | 2012 |
TP53 codon 72 polymorphism with hepatocellular carcinoma: a metaanalysis.
Topics: Aflatoxin B1; Alcohol Drinking; Asian People; Carcinoma, Hepatocellular; Case-Control Studies; Female; Gene Frequency; Genes, p53; Genetic Predisposition to Disease; Genotype; Hepatitis B; Hepatitis C; Humans; Liver Neoplasms; Male; Polymorphism, Single Nucleotide; Risk; Risk Factors; Tumor Suppressor Protein p53 | 2012 |
Synergistic interaction between aflatoxin B1 and hepatitis B virus in hepatocarcinogenesis.
Topics: Aflatoxin B1; Animals; Carcinoma, Hepatocellular; Cocarcinogenesis; Food Contamination; Fungi; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Neoplasms | 2003 |
Hepatocellular carcinoma--a model of human cancer: clinico-pathological features, etiology and pathogenesis.
Topics: Aflatoxin B1; Alcohol Drinking; Carcinoma, Hepatocellular; Hepatitis B; Hepatitis C; Humans; Liver Neoplasms; Risk Factors | 2003 |
Biological relevance of adduct detection to the chemoprevention of cancer.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aflatoxin B1; Anticarcinogenic Agents; Antioxidants; Biomarkers, Tumor; Carcinogens; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Clinical Trials as Topic; Deoxyguanosine; Diet; DNA; DNA Adducts; DNA Damage; DNA Repair; Humans; Immunochemistry; Male; Mass Spectrometry; Models, Chemical; Neoplasms; Oxidative Stress; Oxygen; Prostatic Neoplasms; Proteins; Risk; Sensitivity and Specificity | 2004 |
The pathogenesis of hepatocellular carcinoma is multifactorial event. Novel immunological treatment in prospect.
Topics: Aflatoxin B1; Animals; Carcinoma, Hepatocellular; Controlled Clinical Trials as Topic; Gene Expression; Genes, p53; Genetic Therapy; Hepatectomy; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Immunotherapy; Immunotherapy, Active; Interferon-alpha; Liver Cirrhosis; Liver Neoplasms; Liver Regeneration; Mice; Mice, Transgenic; Multicenter Studies as Topic; Mutation; Prognosis; Prospective Studies; Randomized Controlled Trials as Topic; Retrospective Studies; T-Lymphocytes, Cytotoxic; Transforming Growth Factor beta | 2004 |
[Molecular genetic and epigenetic mechanisms of hepatocarcinogenesis].
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; Cyclin-Dependent Kinase Inhibitor p16; Gene Expression Regulation, Neoplastic; Genes, p53; Genetic Predisposition to Disease; Hepatitis B; Hepatitis C; Humans; Liver Cirrhosis, Alcoholic; Liver Neoplasms; Retinoblastoma Protein; Signal Transduction; Tumor Suppressor Protein p53; Wnt Proteins | 2005 |
Somatic mutations in human cancer: applications in molecular epidemiology.
Topics: Aflatoxin B1; Apoptosis; Breast Neoplasms; Carcinoma, Hepatocellular; Codon; Disease Progression; DNA Damage; DNA Fingerprinting; DNA Repair; DNA, Neoplasm; Female; Genes, p53; Hepatitis B; Humans; Liver Neoplasms; Male; Molecular Epidemiology; Mutagens; Mutation; Mutation, Missense; Neoplasms; Precancerous Conditions; Prognosis; Risk Factors; Time Factors; Tumor Suppressor Proteins | 2005 |
The genetic and environmental basis of hepatocellular carcinoma.
Topics: Aflatoxin B1; Alcoholism; Carcinoma, Hepatocellular; Genetic Predisposition to Disease; Genomic Instability; Hepatitis C; Humans; Liver Neoplasms; Models, Biological | 2006 |
The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics.
Topics: Aflatoxin B1; Biomarkers; Carcinoma, Hepatocellular; Cell Differentiation; Cell Line, Tumor; Constitutive Androstane Receptor; Cytochrome P-450 Enzyme System; Female; Hepatocytes; Humans; Inhibitory Concentration 50; Liver Neoplasms; Metabolic Detoxication, Phase I; Metabolic Detoxication, Phase II; Models, Biological; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; RNA, Messenger; Transcription Factors; Xenobiotics | 2007 |
TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer.
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; Genetic Predisposition to Disease; Hepatitis Viruses; Hepatitis, Chronic; Humans; Incidence; Liver Neoplasms; Mutagenesis; Mutation; Tumor Suppressor Protein p53 | 2007 |
A critical review of biological methods for the detection of fungal toxins in foods and foodstuffs.
Topics: Aflatoxin B1; Aflatoxins; Animals; Artemia; Bacillus subtilis; Biological Assay; Carcinoma, Hepatocellular; Chick Embryo; Chromatography; False Positive Reactions; Fatty Acids; Food Contamination; Gas Chromatography-Mass Spectrometry; Humans; Liver Neoplasms; Mutagenicity Tests; Mycotoxins; T-2 Toxin; Time Factors; Trout | 1982 |
Cellular interactions and metabolism of aflatoxin: an update.
Topics: Abnormalities, Drug-Induced; Aflatoxin B1; Aflatoxins; Animals; Carcinogens; Carcinoma, Hepatocellular; Cytochrome P-450 Enzyme System; DNA; Humans; Liver Neoplasms; Mutation; Mycotoxicosis; Proteins; RNA; Structure-Activity Relationship | 1995 |
p53 proteins and aflatoxin b1: the good, the bad, and the ugly.
Topics: Aflatoxin B1; Carcinogens; Carcinoma, Hepatocellular; Genes, p53; Humans; Liver Neoplasms; Mutation | 1995 |
[Hepatocellular carcinoma: molecular biology aspects].
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Hepatitis B; Hepatitis C; Humans; Liver Cirrhosis, Alcoholic; Liver Neoplasms | 1994 |
Mutagenesis of the H-ras protooncogene and the p53 tumor suppressor gene.
Topics: Aflatoxin B1; Base Sequence; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Codon; DNA Primers; Ethylnitrosourea; Genes, p53; Genes, ras; Humans; Liver Neoplasms; Molecular Sequence Data; Mutagenesis; Neoplasms; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Proto-Oncogenes; Urinary Bladder Neoplasms | 1994 |
[Co-inactivation of the p53 and RB genes in human hepato cellular carcinoma].
Topics: Aflatoxin B1; Animals; Carcinoma, Hepatocellular; Chromosome Aberrations; Gene Deletion; Genes, p53; Genes, Retinoblastoma; Heterozygote; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Mutation; Polymorphism, Restriction Fragment Length; Risk Factors | 1993 |
Duck hepatitis B virus infection, aflatoxin B1 and liver cancer in ducks.
Topics: Aflatoxin B1; Aging; Animals; Carcinoma, Hepatocellular; Carrier State; Ducks; Hepadnaviridae Infections; Hepatitis B Virus, Duck | 1993 |
Molecular dosimetry of aflatoxin exposure: contribution to understanding the multifactorial etiopathogenesis of primary hepatocellular carcinoma with particular reference to hepatitis B virus.
Topics: Aflatoxin B1; Aflatoxins; Animals; Carcinoma, Hepatocellular; Cocarcinogenesis; DNA; DNA Adducts; Epidemiologic Methods; Hepatitis B; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Mice; Mice, Transgenic; Serum Albumin | 1993 |
Hepatocellular carcinoma--carcinogenesis updated.
Topics: Aflatoxin B1; Carcinogens, Environmental; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Hepatitis B; Humans; Liver; Liver Neoplasms; Risk Factors | 1995 |
The p53 tumour suppressor gene: a model for molecular epidemiology of human cancer.
Topics: Aflatoxin B1; Animals; Carcinogens; Carcinoma, Hepatocellular; Dinucleoside Phosphates; Genes, p53; Genes, Tumor Suppressor; Genetic Markers; Genome; Humans; Lung Neoplasms; Molecular Epidemiology; Mutation; Skin Neoplasms; Smoking; Ultraviolet Rays | 1996 |
Molecular and genetic epidemiology of hepatocellular carcinoma: studies in China and Senegal.
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; China; Hepatitis, Viral, Human; Humans; Liver Neoplasms; Male; Senegal | 1995 |
Mutations of the p53 tumor suppressor gene and ras oncogenes in aflatoxin hepatocarcinogenesis.
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; Diet; DNA Adducts; DNA, Neoplasm; Genes, p53; Genes, ras; Humans; Liver Neoplasms; Oxidation-Reduction | 1996 |
[Aflatoxins: current concepts on mechanisms of toxicity and their involvement in the etiology of hepatocellular carcinoma].
Topics: Aflatoxin B1; Carcinogens; Carcinoma, Hepatocellular; Food Contamination; Humans; Incidence; Liver Neoplasms; Risk Factors | 1997 |
The chemistry and biology of aflatoxin B(1): from mutational spectrometry to carcinogenesis.
Topics: Aflatoxin B1; Animals; Carcinogens; Carcinoma, Hepatocellular; Fishes; Genes, p53; Hepatitis B virus; Humans; Liver Neoplasms; Models, Biological; Models, Chemical; Mutagens; Mutation; Rats; Species Specificity | 2001 |
Hepatitis B, aflatoxin B(1), and p53 codon 249 mutation in hepatocellular carcinomas from Guangxi, People's Republic of China, and a meta-analysis of existing studies.
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; China; Diet; DNA Mutational Analysis; DNA, Neoplasm; Environmental Exposure; Genes, p53; Hepatitis B; Hepatitis B virus; Humans; Incidence; Liver Neoplasms; Point Mutation | 2001 |
[Hepatocellular carcinoma without hepatitis virus markers].
Topics: Aflatoxin B1; Alcoholism; Carcinoma, Hepatocellular; DNA Virus Infections; Flaviviridae Infections; GB virus C; Glycogen Storage Disease; Hemochromatosis; Hepatitis, Viral, Human; Humans; Liver Neoplasms; Torque teno virus | 2001 |
Aflatoxins as risk factors for hepatocellular carcinoma in humans.
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; Codon; DNA, Neoplasm; Genes, ras; Hepatitis B; Humans; Liver Neoplasms; Risk Factors; Serum Albumin | 1992 |
Hepatocellular carcinoma: possible etiologies in patients without serologic evidence of hepatitis B virus infection.
Topics: Aflatoxin B1; Aflatoxins; Alcoholism; alpha 1-Antitrypsin Deficiency; Carcinoma, Hepatocellular; Contraceptives, Oral; Hepatitis B; Hepatitis C; Humans; Liver Neoplasms; Schistosomiasis; Smoking | 1989 |
Interactive effects of chemical carcinogens and hepatitis B virus in the pathogenesis of hepatocellular carcinoma.
Topics: Aflatoxin B1; Aflatoxins; Animals; Carcinogens; Carcinoma, Hepatocellular; Disease Models, Animal; Hepatitis B; Hepatitis B virus; Humans; Liver Neoplasms | 1986 |
3 trial(s) available for aflatoxin b1 and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Probiotic supplementation reduces a biomarker for increased risk of liver cancer in young men from Southern China.
Topics: Aflatoxin B1; Biomarkers, Tumor; Carcinoma, Hepatocellular; China; DNA Adducts; Double-Blind Method; Guanine; Humans; Lacticaseibacillus rhamnosus; Liver Neoplasms; Placebos; Probiotics; Propionibacterium; Risk Factors | 2006 |
[Interaction among the relative risk factors of primary liver cancer in a case-control study].
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; Case-Control Studies; China; Hepatitis B; Hepatitis B Surface Antigens; Humans; Liver Neoplasms; Logistic Models; Risk Factors; Water Pollution | 1994 |
Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer.
Topics: Adult; Aflatoxin B1; Aflatoxins; Aged; Animals; Biomarkers; Carcinoma, Hepatocellular; China; Chlorophyllides; DNA Adducts; Female; Food Contamination; Guanine; Humans; Liver Neoplasms; Male; Middle Aged; Risk Factors | 2001 |
211 other study(ies) available for aflatoxin b1 and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Environmental exposure and clinical correlates of hepatocellular carcinoma in New York City: a case only study.
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; Environmental Exposure; Humans; Liver Neoplasms; New York City | 2022 |
Protective role of naringin loaded solid nanoparticles against aflatoxin B1 induced hepatocellular carcinoma.
Topics: Aflatoxin B1; Animals; Anti-Inflammatory Agents; Antioxidants; Carcinoma, Hepatocellular; Drug Carriers; Drug Liberation; Flavanones; Liver; Liver Neoplasms; Male; Nanoparticles; Rats, Wistar; Silymarin | 2022 |
Exposure to aflatoxin B
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; Follow-Up Studies; Hepacivirus; Hepatitis C; Humans; Liver Neoplasms; Pakistan; Risk Factors | 2021 |
Protective effect of copper II-albumin complex against aflatoxin B1- induced hepatocellular toxicity: The impact of Nrf2, PPAR-γ, and NF-kB in these protective effects.
Topics: Aflatoxin B1; Albumins; Animals; Biomarkers; Carcinoma, Hepatocellular; Copper; Liver Neoplasms; NF-E2-Related Factor 2; NF-kappa B; PPAR gamma; Rats | 2022 |
Aflatoxin levels and prevalence of TP53 aflatoxin-mutations in hepatocellular carcinomas in Mexico.
Topics: Aflatoxin B1; Aflatoxins; Carcinoma, Hepatocellular; Female; Humans; Liver Neoplasms; Male; Mexico; Mutation; Prevalence; Tumor Suppressor Protein p53 | 2022 |
Aflatoxin B1 DNA-Adducts in Hepatocellular Carcinoma from a Low Exposure Area.
Topics: Aflatoxin B1; Animals; Carcinoma, Hepatocellular; Cholangiocarcinoma; DNA Adducts; Liver Cirrhosis; Liver Neoplasms; Rats | 2022 |
Aflatoxin M1 in milk does not contribute substantially to global liver cancer incidence.
Topics: Aflatoxin B1; Aflatoxin M1; Animal Feed; Animals; Carcinoma, Hepatocellular; Food Contamination; Humans; Incidence; Liver Neoplasms; Milk | 2022 |
Repurposing PDE5 inhibitor tadalafil and sildenafil as anticancer agent against hepatocellular carcinoma via targeting key events of glucose metabolism and multidrug resistance.
Topics: Aflatoxin B1; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Carbolines; Carcinoma, Hepatocellular; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Repositioning; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Glucose; Imidazoles; Liver Neoplasms; Neoplasm Proteins; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Rats; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2022 |
Presence of aflatoxins in hazelnut paste in Turkey and a risk assessment study.
Topics: Adult; Aflatoxin B1; Aflatoxins; Carcinoma, Hepatocellular; Chromatography, High Pressure Liquid; Corylus; Food Contamination; Humans; Liver Neoplasms; Risk Assessment; Turkey | 2022 |
Whole exome and transcript profiling of liver following aflatoxin B1 exposure in rats.
Topics: Aflatoxin B1; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Exome; Liver; Liver Neoplasms; Rats; Rats, Inbred F344 | 2023 |
An
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; Humans; Liver Neoplasms; Toxicogenetics | 2023 |
Berberine-loaded albumin nanoparticles reverse aflatoxin B1-induced liver hyperplasia.
Topics: Aflatoxin B1; Albumins; Animals; Berberine; Carcinoma, Hepatocellular; Hyperplasia; Liver Neoplasms; Nanoparticles; Rats | 2023 |
Low Frequency of Aflatoxin Induced TP53 Gene Codon 249 Mutation in Hepatocellular Carcinoma from Egyptian Patients Living in the Nile Delta Region.
Topics: Aflatoxin B1; Aflatoxins; Animals; Carcinoma, Hepatocellular; Codon; Egypt; Genes, p53; Humans; Liver Neoplasms; Mutation; Rabbits; Tumor Suppressor Protein p53 | 2023 |
Analysis of miRNA-mRNA regulatory network revealed key genes induced by aflatoxin B1 exposure in primary human hepatocytes.
Topics: Aflatoxin B1; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cells, Cultured; Computational Biology; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Hepatocytes; Humans; Liver Neoplasms; MicroRNAs; Poisons; Protein Interaction Maps; RNA, Messenger; Transcriptome | 2019 |
Low-dose microcystin-LR antagonizes aflatoxin B1 induced hepatocarcinogenesis through decreasing cytochrome P450 1A2 expression and aflatoxin B1-DNA adduct generation.
Topics: Aflatoxin B1; Animals; Carcinoma, Hepatocellular; Cytochrome P-450 CYP1A2; DNA Adducts; Hepatocytes; Humans; Liver; Liver Neoplasms; Male; Marine Toxins; Microcystins; Oxidative Stress; Rats | 2020 |
Resolution of eicosanoid/cytokine storm prevents carcinogen and inflammation-initiated hepatocellular cancer progression.
Topics: Aflatoxin B1; Animals; Apoptosis; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Cell Line; Cyclooxygenase 2; Cytokines; Disease Progression; Eicosanoids; Epoxide Hydrolases; Hep G2 Cells; Humans; Inflammation; Liver Neoplasms; Macrophages; Mice; Neoplastic Processes | 2020 |
Modulation of antioxidant enzymes, SIRT1 and NF-κB by resveratrol and nicotinamide in alcohol-aflatoxin B1-induced hepatocellular carcinoma.
Topics: Aflatoxin B1; Animals; Antioxidants; Carcinoma, Hepatocellular; Ethanol; Liver Neoplasms, Experimental; Male; Neoplasm Proteins; NF-kappa B; Niacinamide; Rats; Resveratrol; Sirtuin 1 | 2021 |
Protective and therapeutic effects of sildenafil and tadalafil on aflatoxin B1-induced hepatocellular carcinoma.
Topics: Aflatoxin B1; Animals; Antioxidants; Carcinoma, Hepatocellular; Lipid Peroxidation; Liver Neoplasms, Experimental; Male; Phosphodiesterase 5 Inhibitors; Poisons; Rats; Sildenafil Citrate; Tadalafil; Vasodilator Agents | 2021 |
Unravelling the pathways of air plasma induced aflatoxin B
Topics: Aflatoxin B1; Aflatoxins; Carcinoma, Hepatocellular; Humans; Liver Neoplasms; Mass Spectrometry | 2021 |
Comprehensive Metabolomic Analysis Reveals Dynamic Metabolic Reprogramming in Hep3B Cells with Aflatoxin B1 Exposure.
Topics: Aflatoxin B1; Amino Acids; Apoptosis; Carcinoma, Hepatocellular; Humans; Lipid Metabolism; Liver Neoplasms; Metabolic Networks and Pathways; Metabolomics; Oxidative Stress; Purines; Pyrimidines; Tandem Mass Spectrometry; Tumor Cells, Cultured | 2021 |
AHR mediates the aflatoxin B1 toxicity associated with hepatocellular carcinoma.
Topics: Active Transport, Cell Nucleus; Aflatoxin B1; Animals; B7-H1 Antigen; Carcinoma, Hepatocellular; Cell Line, Tumor; CRISPR-Cas Systems; Genome, Human; Hepatitis Viruses; Hepatocytes; Humans; Liver Neoplasms; Mice; Receptors, Aryl Hydrocarbon; Xenograft Model Antitumor Assays | 2021 |
Prevalence of metabolic syndrome among adults with liver function injury in rural area of Southwest China: A cross-sectional study.
Topics: Adult; Aflatoxin B1; Aged; Aged, 80 and over; Carcinoma, Hepatocellular; China; Cross-Sectional Studies; DNA, Viral; Female; Hepatitis B; Humans; Liver; Liver Neoplasms; Logistic Models; Male; Metabolic Syndrome; Middle Aged; Prevalence; Risk Factors; Rural Population | 2017 |
Genome-scale mutational signatures of aflatoxin in cells, mice, and human tumors.
Topics: Aflatoxin B1; Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Line, Tumor; China; DNA Mutational Analysis; Hepatitis B Surface Antigens; Humans; Liver Neoplasms; Mice; Mutation | 2017 |
Expression of P62 in hepatocellular carcinoma involving hepatitis B virus infection and aflatoxin B1 exposure.
Topics: Adult; Aflatoxin B1; Biomarkers; Carcinoma, Hepatocellular; Cell Line, Tumor; Female; Follow-Up Studies; Gene Expression; Hepatitis B; Hepatitis B virus; Humans; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Neoplasm Staging; Neovascularization, Pathologic; NF-E2-Related Factor 2; Prognosis; RNA-Binding Proteins; RNA, Messenger; Signal Transduction; Survival Analysis; Tumor Burden | 2017 |
Microcystin-LR increases genotoxicity induced by aflatoxin B1 through oxidative stress and DNA base excision repair genes in human hepatic cell lines.
Topics: Aflatoxin B1; Animals; Carcinoma, Hepatocellular; Catalase; Comet Assay; DNA; DNA Damage; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; Glutathione; Guanine; Hepatocytes; Humans; Liver Neoplasms; Marine Toxins; Microcystins; Oxidative Stress; Superoxide Dismutase; Toxicity Tests | 2018 |
Fisetin Attenuates AKT Associated Growth Promoting Events in AflatoxinB1 Induced Hepatocellular Carcinoma.
Topics: Aflatoxin B1; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Proliferation; Drug Screening Assays, Antitumor; Flavonoids; Flavonols; Liver Neoplasms; Male; Proto-Oncogene Proteins c-akt; Rats; Structure-Activity Relationship | 2018 |
Droplet digital PCR detects high rate of TP53 R249S mutants in cell-free DNA of middle African patients with hepatocellular carcinoma.
Topics: Adolescent; Adult; Aflatoxin B1; Aged; Aged, 80 and over; alpha-Fetoproteins; Cameroon; Carcinoma, Hepatocellular; Case-Control Studies; Cell-Free Nucleic Acids; Central African Republic; DNA, Viral; Female; Gene Expression; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Neoplasms; Male; Middle Aged; Mutation Rate; Polymerase Chain Reaction; Tumor Suppressor Protein p53; Viral Load | 2018 |
1α,25-Dihydroxyvitamin D
Topics: Acyltransferases; Adaptor Proteins, Signal Transducing; Aflatoxin B1; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Dedifferentiation; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Hepatocytes; Humans; Liver Neoplasms; Mice; Mice, Inbred ICR; Phosphatidylinositol 3-Kinases; Phosphoproteins; Poisons; Proto-Oncogene Proteins c-akt; Stem Cells; Transcription Factors; Tumor Cells, Cultured; Vitamin D; Xenograft Model Antitumor Assays; YAP-Signaling Proteins | 2018 |
Clinical features of aflatoxin B1-exposed patients with liver cancer and the molecular mechanism of aflatoxin B1 on liver cancer cells.
Topics: Aflatoxin B1; Aldo-Keto Reductases; Biomarkers, Tumor; Carcinoma, Hepatocellular; Case-Control Studies; Cell Culture Techniques; Cell Proliferation; Environmental Pollutants; Female; Hep G2 Cells; Humans; Lipid Metabolism; Lipids; Liver; Liver Neoplasms; Male; Middle Aged | 2019 |
Hepatitis B virus X antigen and aflatoxin B1 synergistically cause hepatitis, steatosis and liver hyperplasia in transgenic zebrafish.
Topics: Aflatoxin B1; Animals; Animals, Genetically Modified; Carcinoma, Hepatocellular; Caspase 3; Cell Cycle Proteins; Fatty Liver; Gene Expression; Glycogen; Hepatitis B; Humans; Hyperplasia; Immunohistochemistry; Injections, Intraperitoneal; Lipid Metabolism; Liver; Polymerase Chain Reaction; Proliferating Cell Nuclear Antigen; Trans-Activators; Viral Regulatory and Accessory Proteins; Zebrafish | 2013 |
RNA-Seq profiling reveals novel hepatic gene expression pattern in aflatoxin B1 treated rats.
Topics: Aflatoxin B1; Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; E2F1 Transcription Factor; Exons; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Glucuronosyltransferase; High-Throughput Nucleotide Sequencing; Liver; Liver Neoplasms, Experimental; Male; Oligonucleotide Array Sequence Analysis; Precancerous Conditions; Principal Component Analysis; Rats; RNA, Messenger; Sequence Analysis, RNA; Transcriptome | 2013 |
Genetic polymorphisms in DNA repair genes XRCC4 and XRCC5 and aflatoxin B1-related hepatocellular carcinoma.
Topics: Adult; Aflatoxin B1; Aged; Carcinoma, Hepatocellular; Case-Control Studies; Codon; DNA Helicases; DNA-Binding Proteins; Environmental Exposure; Female; Follow-Up Studies; Gene-Environment Interaction; Genetic Predisposition to Disease; Humans; Ku Autoantigen; Liver Neoplasms; Male; Middle Aged; Polymorphism, Genetic; Risk Assessment; Time Factors | 2013 |
Somatic changes in primary liver cancer in Russia: a pilot study.
Topics: Adult; Aflatoxin B1; Aged; Aged, 80 and over; Axin Protein; beta Catenin; Carcinoma, Hepatocellular; Cholangiocarcinoma; Chromosomal Instability; Chromosomes, Human, Pair 18; Cohort Studies; Comorbidity; Female; Genes, p53; Genes, ras; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Liver Neoplasms; Loss of Heterozygosity; Male; Middle Aged; Monosomy; NF-E2-Related Factor 2; Pilot Projects; Point Mutation; Proto-Oncogene Proteins B-raf; PTEN Phosphohydrolase; Risk Factors; Russia; Young Adult | 2013 |
Evaluation of hydro-alcoholic extract of Eclipta alba for its multidrug resistance reversal potential: an in vitro study.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Cell Proliferation; Chromatography, High Pressure Liquid; Doxorubicin; Drug Resistance, Neoplasm; Eclipta; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liquid-Liquid Extraction; Liver Neoplasms; Neoplasms; Plant Extracts; Transfection; Xenobiotics | 2013 |
Global DNA methylation in a population with aflatoxin B1 exposure.
Topics: Acetyltransferases; Adult; Aflatoxin B1; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cohort Studies; DNA Methylation; Epigenesis, Genetic; Female; Genome, Human; Humans; Leukocytes; Long Interspersed Nucleotide Elements; Male; Middle Aged; Risk Factors | 2013 |
Transcriptome profiling of malignant transformed rat hepatic stem-like cells by aflatoxin B1.
Topics: Aflatoxin B1; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Neoplastic Stem Cells; Rats; Signal Transduction | 2014 |
Genome-wide and differential proteomic analysis of hepatitis B virus and aflatoxin B1 related hepatocellular carcinoma in Guangxi, China.
Topics: Adult; Aflatoxin B1; Aged; Aldehyde Reductase; Aldo-Keto Reductases; Carcinoma, Hepatocellular; China; Chromosome Aberrations; Comparative Genomic Hybridization; Disease-Free Survival; Female; Gene Dosage; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm Proteins; Proteomics; Risk; RNA, Messenger; RNA, Neoplasm; Young Adult | 2013 |
Molecular basis of aflatoxin-induced mutagenesis-role of the aflatoxin B1-formamidopyrimidine adduct.
Topics: Aflatoxin B1; Animals; Carcinoma, Hepatocellular; Chlorocebus aethiops; COS Cells; DNA Adducts; DNA Replication; DNA, Single-Stranded; Humans; Liver Neoplasms; Mutagenesis, Site-Directed; Mutation; Polymerase Chain Reaction; Pyrimidines | 2014 |
The p53 mutation spectrum in hepatocellular carcinoma from Guangxi, China : role of chronic hepatitis B virus infection and aflatoxin B1 exposure.
Topics: Adult; Aflatoxin B1; Carcinogenesis; Carcinoma, Hepatocellular; Case-Control Studies; Female; Genes, p53; Hepatitis B, Chronic; Humans; Liver Neoplasms; Male; Middle Aged; Mutation; Neoplasm Recurrence, Local; Prospective Studies; Tumor Suppressor Protein p53 | 2015 |
Genome-wide miRNA-profiling of aflatoxin B1-induced hepatic injury using deep sequencing.
Topics: Aflatoxin B1; Animals; Base Sequence; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Chemical and Drug Induced Liver Injury; Computational Biology; Databases, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genetic Markers; High-Throughput Nucleotide Sequencing; Liver; Liver Neoplasms; Male; MicroRNAs; Molecular Sequence Data; Rats; Rats, Inbred F344; Reproducibility of Results; RNA Precursors | 2014 |
Complete protection against aflatoxin B(1)-induced liver cancer with a triterpenoid: DNA adduct dosimetry, molecular signature, and genotoxicity threshold.
Topics: Aflatoxin B1; Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; DNA Adducts; DNA Damage; Dose-Response Relationship, Drug; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glutathione S-Transferase pi; Imidazoles; Liver Neoplasms, Experimental; Male; Oleanolic Acid; Oligonucleotide Array Sequence Analysis; Poisons; Precancerous Conditions; Rats; Rats, Inbred F344 | 2014 |
Aflatoxin B1 promotes cell growth and invasion in hepatocellular carcinoma HepG2 cells through H19 and E2F1.
Topics: Aflatoxin B1; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Chromatin Immunoprecipitation; E2F1 Transcription Factor; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Poisons; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Long Noncoding; RNA, Messenger; RNA, Small Interfering | 2014 |
MicroRNA-24 modulates aflatoxin B1-related hepatocellular carcinoma prognosis and tumorigenesis.
Topics: Adolescent; Adult; Aflatoxin B1; Aged; Carcinogenesis; Carcinoma, Hepatocellular; Gene Expression Regulation; Humans; Liver Neoplasms; MicroRNAs; Mycotoxins; Tumor Cells, Cultured; Young Adult | 2014 |
Error-prone replication bypass of the primary aflatoxin B1 DNA adduct, AFB1-N7-Gua.
Topics: Aflatoxin B1; Animals; Carcinoma, Hepatocellular; Chlorocebus aethiops; COS Cells; DNA Adducts; DNA Damage; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; Humans; Liver Neoplasms; Point Mutation | 2014 |
Laboratory to community: chemoprevention is the answer.
Topics: Aflatoxin B1; Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; DNA Adducts; Gene Expression Regulation, Neoplastic; Glutathione S-Transferase pi; Imidazoles; Liver Neoplasms, Experimental; Male; Oleanolic Acid | 2014 |
Of mice, rats, and men: could Nrf2 activation protect against aflatoxin heptocarcinogenesis in humans?
Topics: Aflatoxin B1; Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; DNA Adducts; Gene Expression Regulation, Neoplastic; Glutathione S-Transferase pi; Imidazoles; Liver Neoplasms, Experimental; Male; Oleanolic Acid | 2014 |
Association between aflatoxin B1 occupational airway exposure and risk of hepatocellular carcinoma: a case-control study.
Topics: Adult; Aflatoxin B1; Aflatoxins; Albumins; Carcinoma, Hepatocellular; Case-Control Studies; Dust; Enzyme-Linked Immunosorbent Assay; Female; Humans; Inhalation Exposure; Liver Neoplasms; Male; Manufacturing Industry; Occupational Exposure; Paper; Risk Factors; Saccharum | 2014 |
Interaction of DNA repair gene polymorphisms and aflatoxin B1 in the risk of hepatocellular carcinoma.
Topics: Adult; Aflatoxin B1; Aged; Carcinoma, Hepatocellular; Case-Control Studies; Chi-Square Distribution; China; DNA Damage; DNA Repair; DNA Repair Enzymes; Female; Gene-Environment Interaction; Humans; Liver Neoplasms; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Polymorphism, Genetic; Risk Factors | 2014 |
Public health risk associated with the co-occurrence of mycotoxins in spices consumed in Sri Lanka.
Topics: Aflatoxin B1; Capsicum; Carcinogens; Carcinoma, Hepatocellular; Diet; Food Contamination; Humans; Liver Neoplasms; Mycotoxins; Piper; Public Health; Risk Assessment; Spices; Sri Lanka | 2014 |
Molecular characterization of hepatocarcinogenesis using mouse models.
Topics: Aflatoxin B1; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Disease Models, Animal; Female; Gene Expression Profiling; Hepatitis B; Hepatitis B Surface Antigens; Humans; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic | 2015 |
Polymorphisms in the precursor microRNAs and aflatoxin B1-related hepatocellular carcinoma.
Topics: ADAMTS4 Protein; Aflatoxin B1; Carcinoma, Hepatocellular; Case-Control Studies; Cell Line, Tumor; China; Female; Genetic Predisposition to Disease; Hep G2 Cells; Humans; Liver Neoplasms; Male; MicroRNAs; Mutation; Polymorphism, Single Nucleotide; Prognosis; Survival Analysis; Tumor Suppressor Protein p53 | 2016 |
Longitudinal evaluation of aflatoxin exposure in two cohorts in south-western Uganda.
Topics: Adult; Aflatoxin B1; Aflatoxins; Carcinoma, Hepatocellular; Cohort Studies; Environmental Exposure; Female; Food Contamination; Humans; Liver Neoplasms; Longitudinal Studies; Lysine; Male; Middle Aged; Rural Population; Serum Albumin; Uganda | 2015 |
miR-34a screened by miRNA profiling negatively regulates Wnt/β-catenin signaling pathway in Aflatoxin B1 induced hepatotoxicity.
Topics: Aflatoxin B1; beta Catenin; Carcinoma, Hepatocellular; Cluster Analysis; Cyclin D1; DEAD-box RNA Helicases; Down-Regulation; Hep G2 Cells; Humans; Liver Neoplasms; MicroRNAs; Oligonucleotides, Antisense; Proto-Oncogene Proteins c-myc; Real-Time Polymerase Chain Reaction; Ribonuclease III; RNA-Binding Proteins; RNA, Messenger; S Phase Cell Cycle Checkpoints; Sequence Analysis, RNA; Up-Regulation; Wnt Signaling Pathway | 2015 |
Polymorphisms of a Disintegrin and Metalloproteinase with Thrombospondin Motifs 5 and Aflatoxin B1-Related Hepatocellular Carcinoma.
Topics: ADAMTS5 Protein; Aflatoxin B1; Carcinoma, Hepatocellular; Case-Control Studies; Disintegrins; Female; Humans; Liver Neoplasms; Male; Metalloproteases; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Prognosis; Thrombospondins | 2016 |
Fisetin Modulates Antioxidant Enzymes and Inflammatory Factors to Inhibit Aflatoxin-B1 Induced Hepatocellular Carcinoma in Rats.
Topics: Aflatoxin B1; Animals; Antioxidants; Carcinoma, Hepatocellular; Flavonoids; Flavonols; Interleukin-1alpha; Liver Neoplasms, Experimental; Male; Neoplasm Proteins; Oxidative Stress; Oxidoreductases; Rats; Tumor Necrosis Factor-alpha | 2016 |
Crosstalk-eliminated quantitative determination of aflatoxin B1-induced hepatocellular cancer stem cells based on concurrent monitoring of CD133, CD44, and aldehyde dehydrogenase1.
Topics: AC133 Antigen; Aflatoxin B1; Aldehyde Dehydrogenase; Antigens, CD; Carcinoma, Hepatocellular; DNA Adducts; Glycoproteins; Hep G2 Cells; Humans; Hyaluronan Receptors; Liver Neoplasms; Mutation; Neoplastic Stem Cells; Peptides | 2016 |
Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma.
Topics: Aflatoxin B1; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; DNA Methylation; Epigenesis, Genetic; Epigenomics; Gene Expression Profiling; Hepatocytes; Humans; Liver Neoplasms; Oligonucleotide Array Sequence Analysis; RNA, Messenger; Time Factors | 2016 |
Studies on the biological functions of CPS1 in AFB1 induced hepatocarcinogenesis.
Topics: Aflatoxin B1; Albumins; Carbamoyl-Phosphate Synthase (Ammonia); Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Immunoprecipitation; Keratin-1; Liver Neoplasms; Mass Spectrometry; Protein Binding | 2016 |
[Docosahexaenoic acid inhibits aflatoxin B1-induced migration and invasion in hepatocellular carcinoma cells in vitro].
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; Cell Cycle; Cell Movement; Docosahexaenoic Acids; Golgi Apparatus; Hep G2 Cells; Humans; Liver Neoplasms; Mitochondria; Neoplasm Invasiveness | 2016 |
Distinct response of the hepatic transcriptome to Aflatoxin B1 induced hepatocellular carcinogenesis and resistance in rats.
Topics: Aflatoxin B1; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Adhesion; Cell Proliferation; Drug Resistance; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; High-Throughput Nucleotide Sequencing; Liver; Liver Neoplasms; Male; Rats; RNA, Long Noncoding; Sequence Analysis, RNA | 2016 |
AFB1 hepatocarcinogenesis is via lipid peroxidation that inhibits DNA repair, sensitizes mutation susceptibility and induces aldehyde-DNA adducts at p53 mutational hotspot codon 249.
Topics: Aflatoxin B1; Aldehydes; Carcinoma, Hepatocellular; Codon; DNA Adducts; DNA Repair; Genes, p53; Hep G2 Cells; Humans; Lipid Peroxidation; Liver Neoplasms; Mutation | 2017 |
[Association of the Thr241Met polymorphism of DNA repair gene XRCC3 with genetic susceptibility to AFB1-related hepatocellular carcinoma in Guangxi population].
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; Case-Control Studies; China; DNA-Binding Proteins; Genetic Predisposition to Disease; Genotype; Humans; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length | 2008 |
Human aflatoxin albumin adducts quantitatively compared by ELISA, HPLC with fluorescence detection, and HPLC with isotope dilution mass spectrometry.
Topics: Aflatoxin B1; Biomarkers, Tumor; Carcinoma, Hepatocellular; Chromatography, High Pressure Liquid; Environmental Exposure; Enzyme-Linked Immunosorbent Assay; Humans; Incidence; Kenya; Liver Neoplasms; Lysine; Mass Spectrometry; Reproducibility of Results | 2008 |
Glycine N-methyltransferase affects the metabolism of aflatoxin B1 and blocks its carcinogenic effect.
Topics: Aflatoxin B1; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; DNA Adducts; Female; Glycine N-Methyltransferase; Humans; Liver Neoplasms, Experimental; Male; Mice; Mice, Transgenic | 2009 |
Aflatoxin B1 exposure, hepatitis B virus infection, and hepatocellular carcinoma in Taiwan.
Topics: Aflatoxin B1; Biomarkers, Tumor; Carcinoma, Hepatocellular; Case-Control Studies; Chi-Square Distribution; Female; Hepatitis B; Humans; Liver Neoplasms; Logistic Models; Male; Middle Aged; Risk Factors; Taiwan | 2009 |
Natural occurrence of aflatoxins in Chinese peanut butter and sesame paste.
Topics: Aflatoxin B1; Aflatoxins; Arachis; Carcinogens; Carcinoma, Hepatocellular; China; European Union; Food Contamination; Liver Neoplasms; Seeds; Sesamum | 2009 |
Hepatocellular carcinoma in GNMT-/- mice.
Topics: Aflatoxin B1; Animals; Carcinoma, Hepatocellular; Female; Glycine N-Methyltransferase; Liver Neoplasms, Experimental; Male; Mice; Mice, Transgenic; Publications | 2009 |
Establishment of cancer cell lines from rat hepatocholangiocarcinoma and assessment of the role of granulocyte-colony stimulating factor and hepatocyte growth factor in their growth, motility and survival.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cholangiocarcinoma; Granulocyte Colony-Stimulating Factor; Hepatectomy; Hepatocyte Growth Factor; Liver Neoplasms; Male; Neoplasm Metastasis; Proto-Oncogene Proteins c-met; Rats; Rats, Inbred F344; Receptors, Granulocyte Colony-Stimulating Factor | 2009 |
In vitro recapitulating of TP53 mutagenesis in hepatocellular carcinoma associated with dietary aflatoxin B1 exposure.
Topics: Aflatoxin B1; Animals; Carcinogens; Carcinoma, Hepatocellular; Cells, Cultured; DNA Adducts; DNA Damage; Dose-Response Relationship, Drug; Fibroblasts; Genes, p53; Liver Neoplasms; Mice; Mice, Transgenic; Mutagenicity Tests; Mutation | 2009 |
The reduction of cell death and proliferation by p27(Kip1) minimizes DNA damage in an experimental model of genotoxicity.
Topics: Aflatoxin B1; Animals; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Disease Models, Animal; DNA Damage; Hepatocytes; Humans; Immunoenzyme Techniques; Intracellular Signaling Peptides and Proteins; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Protein Serine-Threonine Kinases; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Protein S6 Kinases, 90-kDa; RNA, Messenger; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2009 |
Glutathione-S-transferase A3 knockout mice are sensitive to acute cytotoxic and genotoxic effects of aflatoxin B1.
Topics: Aflatoxin B1; Animals; Blotting, Southern; Blotting, Western; Carcinoma, Hepatocellular; Female; Glutathione Transferase; Humans; Liver Neoplasms; Male; Mice; Mice, Knockout; Models, Animal; Mutagenicity Tests; Mutagens; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; Species Specificity | 2010 |
XPD codon 312 and 751 polymorphisms, and AFB1 exposure, and hepatocellular carcinoma risk.
Topics: Adult; Aflatoxin B1; Aged; Asian People; Carcinoma, Hepatocellular; Case-Control Studies; Female; Genetic Predisposition to Disease; Genotype; Hepatitis B; Hepatitis C; Humans; Liver Neoplasms; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Risk Factors; Sex Factors; Xeroderma Pigmentosum Group D Protein | 2009 |
Evaluation of the genotoxic and anti-genotoxic activities of silybin in human hepatoma cells (HepG2).
Topics: Aflatoxin B1; Benzo(a)pyrene; Bleomycin; Carcinoma, Hepatocellular; Cell Death; Cell Division; Cell Line, Tumor; DNA; DNA Damage; DNA-Formamidopyrimidine Glycosylase; Endonucleases; Escherichia coli Proteins; Humans; Intracellular Space; Liver Neoplasms; Micronuclei, Chromosome-Defective; Mutagens; Reactive Oxygen Species; Silybin; Silymarin | 2010 |
Epidemiology of chronic hepatitis B virus infection, hepatocellular carcinoma, and hepatitis B virus-induced hepatocellular carcinoma.
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; Endemic Diseases; Female; Hepatitis B Vaccines; Hepatitis B, Chronic; Humans; Liver Neoplasms; Male; Risk; Sex Factors | 2010 |
Higher susceptibility to aflatoxin B(1)-related hepatocellular carcinoma in glycine N-methyltransferase knockout mice.
Topics: Aflatoxin B1; Animals; ATP-Binding Cassette Transporters; Autopsy; Carcinoma, Hepatocellular; Crosses, Genetic; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; DNA Primers; Female; Genetic Carrier Screening; Genetic Predisposition to Disease; Glutathione Transferase; Glycine N-Methyltransferase; Liver; Male; Mice; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Transcription, Genetic | 2011 |
Effects of the TP53 p.R249S mutant on proliferation and clonogenic properties in human hepatocellular carcinoma cell lines: interaction with hepatitis B virus X protein.
Topics: Aflatoxin B1; Africa, Western; Asia, Southeastern; Carcinoma, Hepatocellular; Cell Division; Cell Line, Tumor; DNA Primers; Gene Silencing; Humans; Liver Neoplasms; Mutation; Polymorphism, Single Nucleotide; Risk Factors; RNA Interference; Trans-Activators; Tumor Suppressor Protein p53; Viral Regulatory and Accessory Proteins | 2010 |
Proteomic analysis of the transitional endoplasmic reticulum in hepatocellular carcinoma: an organelle perspective on cancer.
Topics: Aflatoxin B1; Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Endoplasmic Reticulum; Humans; Liver Neoplasms; Male; Organelles; Poisons; Proteome; Rats; Rats, Inbred F344; Tandem Mass Spectrometry | 2010 |
Inhibitory effects of quercetin on aflatoxin B1-induced hepatic damage in mice.
Topics: Aflatoxin B1; Animals; Body Weight; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Flavonols; Glutathione; Humans; Liver; Male; Malondialdehyde; Mice; Mice, Inbred ICR; Organ Size; Quercetin; Reactive Oxygen Species | 2010 |
Genetic variations of hepatitis B virus and serum aflatoxin-lysine adduct on high risk of hepatocellular carcinoma in Southern Guangxi, China.
Topics: Adult; Aflatoxin B1; Carcinoma, Hepatocellular; Case-Control Studies; China; Environmental Exposure; Female; Genotype; Hepatitis B virus; Humans; Liver Neoplasms; Lysine; Male; Middle Aged; Risk Factors | 2010 |
Polymorphism in xeroderma pigmentosum complementation group C codon 939 and aflatoxin B1-related hepatocellular carcinoma in the Guangxi population.
Topics: Aflatoxin B1; Asian People; Carcinoma, Hepatocellular; Case-Control Studies; China; Codon; DNA-Binding Proteins; Humans; Liver Neoplasms; Polymorphism, Genetic | 2010 |
Hepatocellular carcinoma and the underlying mechanisms.
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; DNA Repair; Hepacivirus; Hepatitis B; Hepatitis B virus; Hepatitis C; Humans; Incidence; Liver Neoplasms; Mutation; Risk Factors; Trans-Activators; Tumor Suppressor Protein p53; Viral Regulatory and Accessory Proteins | 2010 |
Aflatoxin and PAH exposure biomarkers in a U.S. population with a high incidence of hepatocellular carcinoma.
Topics: Adolescent; Adult; Aflatoxin B1; Aflatoxins; Aged; Biomarkers; Carcinoma, Hepatocellular; Creatinine; Diet; Environmental Exposure; Environmental Pollutants; Female; Hepatitis, Viral, Human; Humans; Liver Neoplasms; Lysine; Male; Middle Aged; Polycyclic Aromatic Hydrocarbons; Pyrenes; Texas; Young Adult | 2010 |
Aetiological differences in demographical, clinical and pathological characteristics of hepatocellular carcinoma in The Gambia.
Topics: Adult; Aflatoxin B1; Aged; Carcinoma, Hepatocellular; Demography; Female; Gambia; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis C; Hepatitis C Antigens; Humans; Liver Neoplasms; Male; Middle Aged; Mutation, Missense; Prevalence; Sex Factors; Tumor Suppressor Protein p53 | 2011 |
Aflatoxin genotoxicity is associated with a defective DNA damage response bypassing p53 activation.
Topics: Aflatoxin B1; beta-Galactosidase; Blotting, Western; Bromodeoxyuridine; Carcinoma, Hepatocellular; Cell Line, Tumor; Comet Assay; DNA Damage; Doxorubicin; Fluorescent Antibody Technique, Indirect; Humans; Immunoenzyme Techniques; Liver Neoplasms; Mutagenicity Tests; Mutation; Phosphorylation; Tumor Suppressor Protein p53 | 2011 |
Aflatoxin B1-DNA adduct formation and mutagenicity in livers of neonatal male and female B6C3F1 mice.
Topics: Aflatoxin B1; Age Factors; Animals; Animals, Newborn; Base Sequence; Carcinogenicity Tests; Carcinoma, Hepatocellular; DNA Adducts; Female; Guanine; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Sequence Data; Mutagens; Mutation Rate; Sequence Analysis, DNA; Sex Factors | 2011 |
Hepatic aflatoxin B1-DNA adducts and TP53 mutations in patients with hepatocellular carcinoma despite low exposure to aflatoxin B1 in southern Japan.
Topics: Adolescent; Adult; Aflatoxin B1; Aged; Aged, 80 and over; Carcinoma, Hepatocellular; Chi-Square Distribution; DNA Adducts; DNA Mutational Analysis; Female; Hepatitis B Surface Antigens; Hepatitis C Antibodies; Humans; Immunohistochemistry; Japan; Liver Neoplasms; Male; Middle Aged; Mutation; Risk Assessment; Risk Factors; Tumor Suppressor Protein p53; Young Adult | 2011 |
Role of aflatoxin B1 as a risk for primary liver cancer in north Indian population.
Topics: Adult; Aflatoxin B1; Alcohol Drinking; Carcinoma, Hepatocellular; Case-Control Studies; Chronic Disease; Female; Food Analysis; Food Microbiology; Guanine; Hepatitis B; Hepatitis C; Humans; India; Liver Diseases; Liver Neoplasms; Male; Middle Aged; Risk Factors | 2011 |
Effect of probiotic fermented milk and chlorophyllin on gene expressions and genotoxicity during AFB₁-induced hepatocellular carcinoma.
Topics: Aflatoxin B1; Animals; Carcinoma, Hepatocellular; Chlorophyllides; Comet Assay; Cultured Milk Products; DNA Damage; Gene Expression; Liver Neoplasms; Male; Mutagens; Probiotics; Rats; Rats, Wistar | 2011 |
RASSF1A hypermethylation is associated with aflatoxin B1 and polycyclic aromatic hydrocarbon exposure in hepatocellular carcinoma.
Topics: Aflatoxin B1; Carcinogens, Environmental; Carcinoma, Hepatocellular; Chi-Square Distribution; China; DNA Adducts; DNA Methylation; Environmental Exposure; Female; Gene Expression Regulation, Neoplastic; Gene-Environment Interaction; Genetic Predisposition to Disease; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Liver Neoplasms; Male; Middle Aged; Multivariate Analysis; Polycyclic Aromatic Hydrocarbons; Prognosis; Risk Assessment; Risk Factors; RNA, Messenger; Time Factors; Tumor Suppressor Proteins | 2012 |
TP53 R249S mutation, genetic variations in HBX and risk of hepatocellular carcinoma in The Gambia.
Topics: Adult; Aflatoxin B1; Carcinoma, Hepatocellular; Case-Control Studies; Female; Gambia; Genes, p53; Genetic Variation; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Polymorphism, Single Nucleotide; Risk Factors; Trans-Activators; Tumor Suppressor Protein p53; Viral Regulatory and Accessory Proteins | 2012 |
Aflatoxin B1 up-regulates insulin receptor substrate 2 and stimulates hepatoma cell migration.
Topics: Aflatoxin B1; Carcinogens; Carcinoma, Hepatocellular; Cell Line; Cell Movement; Hep G2 Cells; Humans; Insulin Receptor Substrate Proteins; Liver; Liver Neoplasms; Receptor, IGF Type 1; Signal Transduction | 2012 |
Etiological and molecular profile of hepatocellular cancer from India.
Topics: Adult; Aflatoxin B1; Aged; Carcinoma, Hepatocellular; DNA, Viral; Female; Fibrosis; Genotype; Hepacivirus; Hepatitis B; Hepatitis B virus; Hepatitis C; Humans; India; Liver Neoplasms; Male; Middle Aged; Odds Ratio; Phylogeny; Prognosis; Retrospective Studies; Risk Factors; RNA, Viral; Viral Load | 2013 |
Dramatic reduction of liver cancer incidence in young adults: 28 year follow-up of etiological interventions in an endemic area of China.
Topics: Adult; Aflatoxin B1; Carcinoma, Hepatocellular; China; Endemic Diseases; Follow-Up Studies; Hepatitis B; Hepatitis B Vaccines; Humans; Incidence; Liver Neoplasms; Male; Middle Aged; Vaccination; Young Adult | 2013 |
Polymorphisms in the coding region of X-ray repair complementing group 4 and aflatoxin B1-related hepatocellular carcinoma.
Topics: Aflatoxin B1; Biomarkers, Tumor; Carcinoma, Hepatocellular; DNA Adducts; DNA-Binding Proteins; Humans; Liver Neoplasms; Neoplasm Metastasis; Prognosis | 2013 |
High frequency of promoter hypermethylation of RASSF1A and p16 and its relationship to aflatoxin B1-DNA adduct levels in human hepatocellular carcinoma.
Topics: Aflatoxin B1; Alternative Splicing; Carcinoma, Hepatocellular; Chromosomes, Human, Pair 3; CpG Islands; Cyclin-Dependent Kinase Inhibitor p16; DNA Adducts; DNA Methylation; Female; Genes, Tumor Suppressor; HeLa Cells; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm Proteins; Promoter Regions, Genetic; Protein Isoforms; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2002 |
Sensitivity of electrospray ionization mass spectrometry detection of codon 249 mutations in the p53 gene compared with RFLP.
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; Codon; DNA Mutational Analysis; Genes, p53; Humans; Liver Neoplasms; Mutation, Missense; Polymorphism, Restriction Fragment Length; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2002 |
Altered DNA mutation spectrum in aflatoxin b1-treated transgenic mice that express the hepatitis B virus x protein.
Topics: Aflatoxin B1; Animals; Bacteriophage lambda; Carcinoma, Hepatocellular; DNA; Female; Hepatitis B, Chronic; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Transgenic; Mutation; Trans-Activators; Transgenes; Viral Regulatory and Accessory Proteins | 2002 |
Determinants of formation of aflatoxin-albumin adducts: a seven-township study in Taiwan.
Topics: Adult; Aflatoxin B1; Aflatoxins; Albumins; Carcinoma, Hepatocellular; Case-Control Studies; Cross-Sectional Studies; Environmental Exposure; Enzyme-Linked Immunosorbent Assay; Female; Glutathione Transferase; Hepatitis B Surface Antigens; Hepatitis C Antibodies; Humans; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Taiwan | 2002 |
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation and its relationship to aflatoxin B1-DNA adducts and p53 mutation in hepatocellular carcinoma.
Topics: Aflatoxin B1; Carcinogens; Carcinoma, Hepatocellular; CpG Islands; DNA; DNA Adducts; DNA Methylation; Gene Silencing; Genes, p53; Humans; Immunohistochemistry; Liver Neoplasms; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Odds Ratio; Promoter Regions, Genetic; Risk Factors; Tumor Cells, Cultured | 2003 |
Hepatitis B and C viruses infection, lifestyle and genetic polymorphisms as risk factors for hepatocellular carcinoma in Haimen, China.
Topics: Adult; Aflatoxin B1; Aged; Alcohol Drinking; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Carcinoma, Hepatocellular; Cytochrome P-450 CYP2E1; Female; Food Contamination; Hepatitis B; Hepatitis C; Humans; Life Style; Liver Neoplasms; Male; Middle Aged; Polymorphism, Genetic; Risk Factors; Smoking | 2002 |
Protective effect of soybean saponins and major antioxidants against aflatoxin B1-induced mutagenicity and DNA-adduct formation.
Topics: Aflatoxin B1; alpha-Tocopherol; Anticarcinogenic Agents; Antioxidants; Ascorbic Acid; Butylated Hydroxytoluene; Carcinoma, Hepatocellular; DNA Adducts; Dose-Response Relationship, Drug; Glycine max; Humans; Liver Neoplasms; Mutagenicity Tests; Mutagens; Mutation; Saponins; Treatment Outcome; Tumor Cells, Cultured | 2002 |
[Alteration of p53 gene during tree shrews' hepatocarcinogenesis].
Topics: Aflatoxin B1; Animals; Carcinoma, Hepatocellular; Cocarcinogenesis; Gene Expression Regulation, Neoplastic; Genetic Variation; Hepatitis B; Hepatitis B virus; Liver Neoplasms, Experimental; Point Mutation; RNA, Neoplasm; Tumor Suppressor Protein p53; Tupaiidae | 2003 |
Susceptibility to aflatoxin B1-related primary hepatocellular carcinoma in mice and humans.
Topics: Aflatoxin B1; Amino Acid Sequence; Animals; Carcinoma, Hepatocellular; Case-Control Studies; Cocarcinogenesis; Conserved Sequence; Female; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Mice, Transgenic; Middle Aged; Molecular Sequence Data | 2003 |
[Differentially expressed genes in hepatocellular carcinoma of tree shrew induced by different factors].
Topics: Aflatoxin B1; Animals; Carcinoma, Hepatocellular; Female; Gene Expression Profiling; Hepatitis B; Humans; Liver Neoplasms, Experimental; Male; Tupaiidae | 2003 |
Differential expression of genes during aflatoxin B(1)-induced hepatocarcinogenesis in tree shrews.
Topics: Aflatoxin B1; Animals; Carcinoma, Hepatocellular; Gene Expression Regulation, Neoplastic; Liver Neoplasms; Oligonucleotide Array Sequence Analysis; Tupaiidae | 2004 |
Low hepatic glutathione S-transferase and increased hepatic DNA adduction contribute to increased tumorigenicity of aflatoxin B1 in newborn and partially hepatectomized mice.
Topics: Aflatoxin B1; Animals; Animals, Newborn; Carcinoma, Hepatocellular; DNA Adducts; Glutathione Transferase; Hepatectomy; Hepatocytes; Liver Neoplasms; Mice | 2004 |
Comparison of the expression of beta-catenin in hepatocellular carcinoma in areas with high and low levels of exposure to aflatoxin B1.
Topics: Adult; Aflatoxin B1; Aged; beta Catenin; Carcinoma, Hepatocellular; China; Cytoskeletal Proteins; Environmental Exposure; Female; Hepatitis B; Humans; Immunohistochemistry; Liver Neoplasms; Malaysia; Male; Middle Aged; Mutation; Sequence Analysis, DNA; Trans-Activators; Tumor Suppressor Protein p53 | 2004 |
Increased levels of aflatoxin-albumin adducts are associated with CYP3A5 polymorphisms in The Gambia, West Africa.
Topics: Adolescent; Adult; Aflatoxin B1; Aflatoxins; Aged; Albumins; Base Sequence; Carcinoma, Hepatocellular; Child; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA; Female; Gambia; Gene Expression; Gene Frequency; Genetic Variation; Haplotypes; Humans; Liver Neoplasms; Male; Middle Aged; Mutagens; Polymorphism, Genetic; Risk Factors | 2004 |
Silencing of glutathione S-transferase P1 by promoter hypermethylation and its relationship to environmental chemical carcinogens in hepatocellular carcinoma.
Topics: Aflatoxin B1; Carcinogens, Environmental; Carcinoma, Hepatocellular; DNA Adducts; DNA Methylation; DNA, Neoplasm; Environmental Exposure; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Gene Silencing; Glutathione S-Transferase pi; Glutathione Transferase; Humans; Isoenzymes; Liver Neoplasms; Male; Middle Aged; Polycyclic Aromatic Hydrocarbons; Promoter Regions, Genetic; Risk Factors; Taiwan | 2005 |
Associated factors in modulating aflatoxin B1-albumin adduct level in three Chinese populations.
Topics: Aflatoxin B1; Aflatoxins; Age Distribution; Albumins; Analysis of Variance; Biomarkers; Carcinoma, Hepatocellular; Chi-Square Distribution; China; Cohort Studies; Endemic Diseases; Female; Hepatitis, Viral, Human; Humans; Incidence; Linear Models; Liver Neoplasms; Male; Probability; Registries; Severity of Illness Index; Sex Distribution | 2005 |
Alleviation of aflatoxin B1-induced oxidative stress in HepG2 cells by volatile extract from Allii Fistulosi Bulbus.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aflatoxin B1; Allium; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Deoxyguanosine; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Glutathione; Glutathione Transferase; Hepatocytes; Humans; Lipid Peroxidation; Liver Neoplasms; Oxidative Stress; Plant Extracts; Reactive Oxygen Species; Thiobarbituric Acid Reactive Substances; Volatilization | 2005 |
Use of a rainbow trout oligonucleotide microarray to determine transcriptional patterns in aflatoxin B1-induced hepatocellular carcinoma compared to adjacent liver.
Topics: Aflatoxin B1; Animals; Carcinoma, Hepatocellular; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Liver; Liver Neoplasms; Oligonucleotide Array Sequence Analysis; Oncorhynchus mykiss; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Transcription, Genetic | 2005 |
[A study about the association of detoxication gene GSTM1 polymorphism and the susceptibility to aflatoxin B1-related hepatocellular carcinoma].
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; Genetic Predisposition to Disease; Glutathione Transferase; Humans; Liver Neoplasms; Polymorphism, Genetic | 2005 |
Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells.
Topics: Acetaminophen; Aflatoxin B1; Amiodarone; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Chlorpromazine; Cytochrome P-450 Enzyme System; Dimethyl Sulfoxide; Gene Expression; Gene Expression Profiling; Glucuronosyltransferase; Hepatocytes; Humans; Inhibitory Concentration 50; Isoenzymes; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Xenobiotics | 2006 |
Comparative acute and combinative toxicity of aflatoxin B1 and fumonisin B1 in animals and human cells.
Topics: Aflatoxin B1; Animals; Bronchi; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Cell Survival; Cyprinodontiformes; Drug Interactions; Epithelial Cells; Food Contamination; Fumonisins; Humans; Liver Neoplasms; Male; Mycotoxins; Rats; Rats, Inbred F344 | 2006 |
[Study on the detoxication gene gstM1-gstT1-null and susceptibility to aflatoxin B1 related hepatocellular carcinoma in Guangxi].
Topics: Adult; Aflatoxin B1; Aged; Alleles; Asian People; Carcinoma, Hepatocellular; Case-Control Studies; China; Environmental Exposure; Female; Genetic Predisposition to Disease; Genotype; Glutathione Transferase; Hepatitis B; Humans; Liver Neoplasms; Male; Middle Aged; Polymorphism, Genetic | 2005 |
Aflatoxin B1 and polycyclic aromatic hydrocarbon adducts, p53 mutations and p16 methylation in liver tissue and plasma of hepatocellular carcinoma patients.
Topics: Adult; Aflatoxin B1; Aged; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cyclin-Dependent Kinase Inhibitor p16; DNA Adducts; DNA Methylation; Female; Genes, p16; Genes, p53; Humans; Immunohistochemistry; Liver; Liver Neoplasms; Male; Middle Aged; Mutation; Polycyclic Aromatic Hydrocarbons; Tumor Suppressor Protein p53 | 2006 |
Protective effects of garlic sulfur compounds against DNA damage induced by direct- and indirect-acting genotoxic agents in HepG2 cells.
Topics: Aflatoxin B1; Allyl Compounds; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Cysteine; Disulfides; DNA Damage; Garlic; Humans; Liver Neoplasms; Mutagens; Sulfhydryl Compounds; Sulfides; Sulfinic Acids; Sulfur Compounds | 2006 |
Clinical significance of aflatoxin, mutant P53 gene and sIL-2 receptor in liver cirrhosis and hepatocellular carcinoma.
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; DNA Mutational Analysis; Female; Genes, p53; Hepatitis B, Chronic; Humans; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Mutation; Receptors, Interleukin-2; Risk Factors | 2006 |
Hepatitis B virus x gene and cyanobacterial toxins promote aflatoxin B1-induced hepatotumorigenesis in mice.
Topics: Aflatoxin B1; Animals; Bacterial Toxins; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cyanobacteria Toxins; Dose-Response Relationship, Drug; Drug Synergism; Liver Neoplasms; Male; Marine Toxins; Mice; Mice, Transgenic; Microcystins; Peptides, Cyclic; Poisons; Polymerase Chain Reaction; Time Factors; Trans-Activators; Viral Regulatory and Accessory Proteins | 2006 |
Potent protective effect of isoimperatorin against aflatoxin B1-inducible cytotoxicity in H4IIE cells: bifunctional effects on glutathione S-transferase and CYP1A.
Topics: Aflatoxin B1; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Cytochrome P-450 CYP1A1; Drugs, Chinese Herbal; Furocoumarins; Glutathione Transferase; Liver Neoplasms; Rats | 2006 |
Novel adenine adducts, N7-guanine-AFB1 adducts, and p53 mutations in patients with schistosomiasis and aflatoxin exposure.
Topics: Adult; Aflatoxin B1; Animals; Carcinoma, Hepatocellular; DNA Adducts; Female; Genes, p53; Humans; Liver Neoplasms; Male; Mass Spectrometry; Middle Aged; Mutation; Schistosoma haematobium; Schistosoma mansoni; Schistosomiasis | 2006 |
Urinary 8-oxodeoxyguanosine, aflatoxin B1 exposure and hepatitis B virus infection and hepatocellular carcinoma in Taiwan.
Topics: Adult; Aflatoxin B1; Carcinoma, Hepatocellular; Case-Control Studies; Cohort Studies; Deoxyadenine Nucleotides; DNA Damage; Female; Hepatitis B; Humans; Liver Neoplasms; Male; Middle Aged; Oxidative Stress; Risk; Sex Factors; Taiwan | 2007 |
Is correction for protein concentration appropriate for protein adduct dosimetry? Hypothesis and clues from an aflatoxin B1-exposed population.
Topics: Adult; Aflatoxin B1; Albumins; Biomarkers; Carcinoma, Hepatocellular; China; Environmental Exposure; Female; Humans; Male; Models, Biological; Oxidative Stress; Risk Factors | 2007 |
Gene expression analysis during tumor enhancement by the dietary phytochemical, 3,3'-diindolylmethane, in rainbow trout.
Topics: Aflatoxin B1; Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Dietary Supplements; Estradiol; Gene Expression Profiling; Indoles; Liver; Liver Neoplasms; Oligonucleotide Array Sequence Analysis; Oncorhynchus mykiss; Plant Preparations | 2007 |
[A case-control study on the association of hepatocellular carcinoma with genetic polymorphisms of CYP3A5 in a highly aflatoxin B1 contaminated Guangxi area].
Topics: Adult; Aflatoxin B1; Carcinoma, Hepatocellular; Case-Control Studies; China; Cytochrome P-450 CYP3A; Female; Food Contamination; Genotype; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide | 2007 |
[Changes of beta catenin in carcinogenesis in rat livers induced by aflatoxin B1].
Topics: Aflatoxin B1; Animals; beta Catenin; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Liver; Male; Rats; Rats, Sprague-Dawley | 2007 |
Prevalence of aflatoxin B1 in liver biopsies of proven hepatocellular carcinoma in India determined by an in-house immunoperoxidase test.
Topics: Adult; Aflatoxin B1; Aged; Aged, 80 and over; Biopsy; Carcinoma, Hepatocellular; Enzyme-Linked Immunosorbent Assay; Female; Hepatitis B Surface Antigens; Hepatitis C Antibodies; Humans; India; Liver; Male; Middle Aged; Serum | 2007 |
Stimulation of sister chromatid exchanges and mutation by aflatoxin B1-DNA adducts in Saccharomyces cerevisiae requires MEC1 (ATR), RAD53, and DUN1.
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; Cell Cycle Proteins; Checkpoint Kinase 2; Cytochrome P-450 CYP1A2; DNA Adducts; DNA Replication; Intracellular Signaling Peptides and Proteins; Mutagens; Mutation; Phenotype; Protein Kinases; Protein Serine-Threonine Kinases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sister Chromatid Exchange; Spectrometry, Mass, Electrospray Ionization; Ultraviolet Rays | 2008 |
Protective effect of Kalpaamruthaa in combating the oxidative stress posed by aflatoxin B1-induced hepatocellular carcinoma with special reference to flavonoid structure-activity relationship.
Topics: Aflatoxin B1; Analysis of Variance; Animals; Carcinoma, Hepatocellular; Catalase; Glutathione Peroxidase; Lipid Peroxidation; Male; Malondialdehyde; Oxidative Stress; Plant Extracts; Rats; Rats, Wistar; Superoxide Dismutase; Uric Acid | 2008 |
Hepatitis B virus infection contributes to oxidative stress in a population exposed to aflatoxin B1 and high-risk for hepatocellular carcinoma.
Topics: Adult; Aflatoxin B1; Biomarkers; Carcinoma, Hepatocellular; Female; Hepatitis B; Humans; Liver Neoplasms; Male; Middle Aged; Oxidative Stress; Risk | 2008 |
Urinary 15-F2t-isoprostane, aflatoxin B1 exposure and hepatitis B virus infection and hepatocellular carcinoma in Taiwan.
Topics: Aflatoxin B1; Biomarkers; Carcinoma, Hepatocellular; Death Certificates; Dinoprost; Hepatitis B; Humans; Interviews as Topic; Lipid Peroxidation; Liver Neoplasms; Mass Screening; Odds Ratio; Reference Values; Registries; Taiwan | 2008 |
Proteome analysis of aflatoxin B1-induced hepatocarcinogenesis in tree shrew (Tupaia belangeri chinensis) and functional identification of candidate protein peroxiredoxin II.
Topics: Adult; Aflatoxin B1; Aged; Animals; Carcinoma, Hepatocellular; Electrophoresis, Gel, Two-Dimensional; Female; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Mass Spectrometry; Middle Aged; Peroxiredoxins; Reverse Transcriptase Polymerase Chain Reaction; Tupaia | 2008 |
Modulatory effect of Gynandropsis gynandra L. on glucose metabolizing enzymes in aflatoxin B1-induced hepatocellular carcinoma in rats.
Topics: Aflatoxin B1; Animals; Carcinoma, Hepatocellular; Fructose-Bisphosphatase; Gluconeogenesis; Glucose; Glucose-6-Phosphatase; Glucose-6-Phosphate Isomerase; Glycolysis; Hexokinase; Liver Neoplasms; Male; Plant Extracts; Rats; Rats, Wistar | 2007 |
Large-scale analysis of the genetic and epigenetic alterations in hepatocellular carcinoma from Southeast China.
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; China; Cyclin-Dependent Kinase Inhibitor p16; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Hepatitis B; Hepatitis B virus; Hepatocytes; Humans; Liver; Liver Neoplasms; Male; Membrane Glycoproteins; Middle Aged; Mutation; Neoplasm Recurrence, Local; Survival Rate; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2008 |
Chromosome instability in human hepatocellular carcinoma depends on p53 status and aflatoxin exposure.
Topics: Adult; Aflatoxin B1; Aged; Amino Acid Substitution; Asian People; beta Catenin; Carcinoma, Hepatocellular; China; Chromosomal Instability; Chromosomes, Human, Pair 13; Female; France; Hepatitis B; Hepatitis B virus; Humans; Italy; Loss of Heterozygosity; Male; Middle Aged; Mutagens; Mutation, Missense; Poisons; Risk Factors; Tumor Suppressor Protein p53; White People | 2008 |
The polymorphism of XRCC3 codon 241 and AFB1-related hepatocellular carcinoma in Guangxi population, China.
Topics: Adult; Aflatoxin B1; Aged; Carcinoma, Hepatocellular; Case-Control Studies; China; Codon; DNA Damage; DNA Repair; DNA-Binding Proteins; Female; Genetic Predisposition to Disease; Humans; Liver Neoplasms; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic | 2008 |
[Pathogenesis of human cancer development due to environmental factors].
Topics: Adult; Aflatoxin B1; Aflatoxins; Animals; Bronchi; Carcinogens; Carcinoma, Hepatocellular; Carcinoma, Renal Cell; Female; Humans; Kidney Neoplasms; Liver Neoplasms; Lung Neoplasms; Male; Metaproterenol; Mice; Microscopy, Electron; Microscopy, Electron, Scanning; Ochratoxins; p-Dimethylaminoazobenzene; Rats | 1984 |
[Epidemiological analysis of the etiological relationship between primary hepatocarcinoma and hepatitis B virus].
Topics: Adolescent; Adult; Aflatoxin B1; Aflatoxins; Age Factors; Aged; Carcinoma, Hepatocellular; Child; Child, Preschool; China; Female; Food Contamination; Hepatitis B; Hepatitis B Surface Antigens; Humans; Infant; Infant, Newborn; Liver Neoplasms; Male; Middle Aged; Sex Factors | 1984 |
An enzyme-linked immunosorbent procedure for assaying aflatoxin B1.
Topics: Aflatoxin B1; Aflatoxins; Carcinoma, Hepatocellular; Enzyme-Linked Immunosorbent Assay; Gambia; Humans; Liver Neoplasms; Radioimmunoassay | 1984 |
The role of dietary aflatoxin in the genesis of hepatocellular cancer in developing countries.
Topics: Aflatoxin B1; Aflatoxins; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Child; Cocarcinogenesis; Developing Countries; Dietary Proteins; DNA Replication; Food Contamination; Hepatitis B; Humans; Kwashiorkor; Liver; Liver Neoplasms; Microsomes, Liver; Mixed Function Oxygenases | 1984 |
Glucocorticoid enhancement of aflatoxin B1 cytotoxicity in differentiated rat hepatoma cultures.
Topics: Aflatoxin B1; Aflatoxins; Animals; Biotransformation; Carcinoma, Hepatocellular; Cell Differentiation; Cell Division; Cell Line; Dexamethasone; Hybrid Cells; Liver Neoplasms; Methylcholanthrene; Rats | 1980 |
Analysis of aflatoxin B1 in human tissues with high-pressure liquid chromatography.
Topics: Aflatoxin B1; Aflatoxins; Animals; Carcinoma, Hepatocellular; Chromatography, High Pressure Liquid; Humans; Liver; Liver Neoplasms; Mice; Reye Syndrome | 1981 |
[Is aflatoxin B1 a hepatic carcinogen in man?].
Topics: Aflatoxin B1; Aflatoxins; Animals; Carcinoma, Hepatocellular; Humans; Liver Neoplasms; Rats | 1982 |
Aflatoxins, B1, B2, G1, G2 in primary liver cell carcinoma.
Topics: Adult; Aflatoxin B1; Aflatoxins; Carcinoma, Hepatocellular; Female; Hepatitis B virus; Humans; Liver Neoplasms; Male | 1982 |
Metabolic activation of benzo[a]pyrene, aflatoxin B1, and dimethylnitrosamine by a human hepatoma cell line.
Topics: Aflatoxin B1; Aflatoxins; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Carcinogens; Carcinoma, Hepatocellular; Cell Line; Dimethylnitrosamine; Humans; Liver Neoplasms; Middle Aged; Sister Chromatid Exchange | 1982 |
Sister-chromatid exchange induction by indirect mutagens/carcinogens, aryl hydrocarbon hydroxylase activity and benzo[alpha]pyrene metabolism in cultured human hepatoma cells.
Topics: Aflatoxin B1; Aflatoxins; Aryl Hydrocarbon Hydroxylases; Benz(a)Anthracenes; Benzopyrenes; Carcinoma, Hepatocellular; Cell Line; Crossing Over, Genetic; Cyclophosphamide; Enzyme Induction; Humans; Liver Neoplasms; Mutagenicity Tests; Sister Chromatid Exchange | 1983 |
Codon 249 mutation of the p53 gene is a rare event in hepatocellular carcinomas from ethnic Chinese in Singapore.
Topics: Adult; Aflatoxin B1; Aged; Base Sequence; Carcinoma, Hepatocellular; China; Codon; Female; Genes, p53; Humans; Liver Neoplasms; Male; Middle Aged; Molecular Sequence Data; Point Mutation; Singapore | 1995 |
Characterization of a murine p53ser246 mutant equivalent to the human p53ser249 associated with hepatocellular carcinoma and aflatoxin exposure.
Topics: Aflatoxin B1; Amino Acid Sequence; Animals; Arginine; Base Sequence; Carcinoma, Hepatocellular; Codon; Creatine Kinase; Genes, p53; Hepatitis B; Humans; Liver Neoplasms; Mice; Molecular Sequence Data; Mutation; Neoplastic Stem Cells; Osteosarcoma; Promoter Regions, Genetic; Protein Conformation; Sequence Homology, Amino Acid; Serine; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1995 |
Aflatoxin exposure in Singapore: blood aflatoxin levels in normal subjects, hepatitis B virus carriers and primary hepatocellular carcinoma patients.
Topics: Adult; Aflatoxin B1; Aflatoxins; Carcinoma, Hepatocellular; Chromatography, High Pressure Liquid; Environmental Exposure; Female; Food Contamination; Hepatitis B; Humans; Liver Neoplasms; Male; Middle Aged; Singapore | 1994 |
p53 mutations in nonmalignant human liver: fingerprints of aflatoxins?
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; Genes, p53; Humans; Liver Neoplasms; Mutation | 1995 |
Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1.
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; Case-Control Studies; China; Codon; DNA; Epoxide Hydrolases; Genes, p53; Genetic Predisposition to Disease; Genetic Variation; Genotype; Glutathione Transferase; Hepatitis B Surface Antigens; Humans; Inactivation, Metabolic; Liver Neoplasms; Point Mutation; Polymerase Chain Reaction; Reference Values; Risk Factors; Serum Albumin | 1995 |
State of the p53 gene in hepatocellular carcinomas of ground squirrels and woodchucks with past and ongoing infection with hepadnaviruses.
Topics: Aflatoxin B1; Amino Acid Sequence; Animals; Base Sequence; Blotting, Southern; Carcinoma, Hepatocellular; DNA, Complementary; Genes, p53; Hepadnaviridae Infections; Hepatitis B; Hepatitis B Virus, Woodchuck; Hepatitis, Viral, Animal; Marmota; Molecular Sequence Data; Mutation; Orthohepadnavirus; Sciuridae; Species Specificity | 1994 |
Metabolism and cytotoxicity of aflatoxin B1 in cultured rat hepatocytes and nonparenchymal cells: implications for tumorigenesis.
Topics: Aflatoxin B1; Animals; Binding Sites; Carcinogenicity Tests; Carcinoma, Hepatocellular; Cell Count; Cells, Cultured; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Dose-Response Relationship, Drug; Drug Storage; Glutathione Transferase; Kupffer Cells; L-Lactate Dehydrogenase; Liver; Liver Neoplasms; Male; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Solubility; Water | 1994 |
Geographic variation of p53 mutational profile in nonmalignant human liver.
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; China; Codon; Genes, p53; Humans; Liver; Liver Neoplasms; Point Mutation; Thailand; United States | 1994 |
Duck hepatitis B virus infection, aflatoxin B1 and liver cancer in domestic Chinese ducks.
Topics: Aflatoxin B1; Animals; Base Sequence; Carcinoma, Hepatocellular; China; DNA Damage; DNA, Neoplasm; DNA, Viral; Ducks; Hepadnaviridae Infections; Hepatitis B Virus, Duck; Liver; Liver Neoplasms; Molecular Sequence Data; Polymerase Chain Reaction; Poultry Diseases; Risk Factors | 1994 |
p53 mutations and aflatoxin B1 exposure in hepatocellular carcinoma patients from Thailand.
Topics: Adolescent; Adult; Aflatoxin B1; Aged; Amino Acid Sequence; Carcinoma, Hepatocellular; DNA, Neoplasm; Female; Genes, p53; Genotype; Glutathione Transferase; Humans; Liver Neoplasms; Male; Middle Aged; Molecular Sequence Data; Mutation; Prevalence | 1993 |
Aflatoxin B1-induced rat hepatic hyperplastic nodules do not exhibit a site-specific mutation within the p53 gene.
Topics: Aflatoxin B1; Animals; Base Sequence; Carcinoma, Hepatocellular; Codon; Disease Models, Animal; Genes, p53; Humans; Hyperplasia; Liver; Liver Neoplasms, Experimental; Male; Molecular Sequence Data; Mutation; Rats; Rats, Inbred F344 | 1993 |
Aberrations of p53 gene in human hepatocellular carcinoma from China.
Topics: Aflatoxin B1; Base Sequence; Blotting, Southern; Carcinoma, Hepatocellular; China; Chromosome Aberrations; DNA, Neoplasm; DNA, Single-Stranded; Environmental Exposure; Genes, p53; Hepatitis B; Humans; Liver Neoplasms; Methylation; Molecular Sequence Data; Mutation; Polymerase Chain Reaction; Risk Factors | 1993 |
Detection of aflatoxin B1-DNA adducts in human placenta and cord blood.
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; DNA; DNA Adducts; Enzyme-Linked Immunosorbent Assay; Female; Fetal Blood; Humans; Liver Neoplasms; Placenta; Pregnancy | 1993 |
Immunohistochemical detection of aflatoxin B1-DNA adducts and hepatitis B virus antigens in hepatocellular carcinoma and nontumorous liver tissue.
Topics: Aflatoxin B1; Animals; Carcinoma, Hepatocellular; DNA; DNA Adducts; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Hepatitis B Antigens; Hepatitis B Surface Antigens; Humans; Immunohistochemistry; Liver; Liver Neoplasms; Rats; Trans-Activators; Viral Regulatory and Accessory Proteins | 1993 |
Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes.
Topics: Aflatoxin B1; Animals; Base Composition; Base Sequence; Biotransformation; Carcinoma, Hepatocellular; Codon; DNA Mutational Analysis; Genes, p53; Humans; Liver; Liver Neoplasms; Microsomes, Liver; Molecular Sequence Data; Mutagens; Point Mutation; Rats; Tumor Cells, Cultured | 1993 |
Changes in GTP-dependent fusion and ras-related proteins in membranes from rat hepatocellular carcinomas.
Topics: Aflatoxin B1; Animals; Carcinoma, Hepatocellular; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum, Rough; Golgi Apparatus; Guanosine Triphosphate; Intracellular Membranes; Liver Neoplasms; Male; Membrane Fusion; Microsomes, Liver; Protein Binding; ras Proteins; Rats; Rats, Inbred F344; Subcellular Fractions | 1995 |
Effect of eugenol on the genotoxicity of established mutagens in the liver.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aflatoxin B1; Animals; Antimutagenic Agents; Benzo(a)pyrene; Carcinoma, Hepatocellular; Cytochrome P-450 Enzyme System; DNA; Electrophoresis, Agar Gel; Eugenol; Glutathione Transferase; Humans; Liver; Liver Neoplasms; Male; Micronucleus Tests; Mutagenicity Tests; Mutagens; Rats; Rats, Wistar; Salmonella typhimurium; Tumor Cells, Cultured | 1996 |
An aflatoxin-associated mutational hotspot at codon 249 in the p53 tumor suppressor gene occurs in hepatocellular carcinomas from Mexico.
Topics: Adult; Aflatoxin B1; Aged; Animals; Base Sequence; Carcinogens; Carcinoma, Hepatocellular; Codon; Female; Genes, p53; Hepatitis B; Hepatitis C; Humans; Liver Neoplasms; Male; Middle Aged; Molecular Sequence Data; Mutation; Rabbits; Serum Albumin | 1996 |
Mutational properties of the primary aflatoxin B1-DNA adduct.
Topics: Aflatoxin B1; Bacteriophage M13; Base Sequence; Carcinoma, Hepatocellular; DNA Adducts; DNA, Viral; Escherichia coli; Guanine; Humans; Liver Neoplasms; Models, Molecular; Molecular Sequence Data; Mutagenesis; SOS Response, Genetics; Structure-Activity Relationship | 1996 |
Chronic hepatitis B carriers with null genotypes of glutathione S-transferase M1 and T1 polymorphisms who are exposed to aflatoxin are at increased risk of hepatocellular carcinoma.
Topics: Adult; Aflatoxin B1; Aflatoxins; Aged; Albumins; Carcinoma, Hepatocellular; Carrier State; Cohort Studies; Genotype; Glutathione Transferase; Hepatitis B; Hepatitis B Surface Antigens; Humans; Liver Neoplasms; Male; Middle Aged; Polymorphism, Genetic; Risk Factors; Taiwan | 1996 |
Effects of multiple risk factors for hepatocellular carcinoma on formation of aflatoxin B1-DNA adducts.
Topics: Aflatoxin B1; Age Factors; Alcohol Drinking; Biomarkers; Carcinogens; Carcinoma, Hepatocellular; Carrier State; DNA Adducts; Guanine; Hepatitis B; Hepatitis B Surface Antigens; Humans; Liver Neoplasms; Logistic Models; Male; Multivariate Analysis; Prospective Studies; Risk Factors; Smoking; Taiwan | 1996 |
Epidemiology of human aflatoxin exposures and their relationship to liver cancer.
Topics: Adult; Aflatoxin B1; Arachis; Biomarkers; Carcinogens, Environmental; Carcinoma, Hepatocellular; Case-Control Studies; Diet; DNA Damage; Edible Grain; Environmental Exposure; Food Contamination; Food Microbiology; Genes, p53; Humans; Liver Neoplasms | 1996 |
Absence of mutations in the p53 tumor suppressor gene in woodchuck hepatocellular carcinomas associated with hepadnavirus infection and intake of aflatoxin B1.
Topics: Aflatoxin B1; Animals; Carcinogens; Carcinoma, Hepatocellular; DNA, Viral; Exons; Genes, p53; Hepatitis B; Hepatitis B Virus, Woodchuck; Liver Neoplasms; Marmota; Mutation | 1996 |
p53 mutations, chronic hepatitis B virus infection, and aflatoxin exposure in hepatocellular carcinoma in Taiwan.
Topics: Aflatoxin B1; Biomarkers, Tumor; Carcinoma, Hepatocellular; DNA Adducts; DNA, Neoplasm; Female; Genes, p53; Genetic Markers; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm Staging; Point Mutation | 1997 |
An intercalation inhibitor altering the target selectivity of DNA damaging agents: synthesis of site-specific aflatoxin B1 adducts in a p53 mutational hotspot.
Topics: Aflatoxin B1; Binding Sites; Carcinogens; Carcinoma, Hepatocellular; DNA Damage; Humans; Liver Neoplasms; Mutagenesis, Site-Directed; Mutation; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1997 |
Modulating effect of Semecarpus anacardium Linn. nut extract on glucose metabolizing enzymes in aflatoxin B1-induced experimental hepatocellular carcinoma.
Topics: Aflatoxin B1; Animals; Carcinoma, Hepatocellular; Glucose; Glucose-6-Phosphatase; Hexokinase; Liver; Male; Medicine, Ayurvedic; Nuts; Phytotherapy; Plant Extracts; Rats; Rats, Wistar | 1997 |
[Synergism of three risk factors in hepatocellular carcinogenicity].
Topics: Adult; Aflatoxin B1; Carcinoma, Hepatocellular; DNA, Viral; Female; Hepacivirus; Hepatitis B virus; Humans; Liver Neoplasms; Male; Middle Aged; Risk Factors; RNA, Viral | 1996 |
The p53 codon 249 mutational hotspot in hepatocellular carcinoma is not related to selective formation or persistence of aflatoxin B1 adducts.
Topics: Aflatoxin B1; Animals; Binding Sites; Carcinoma, Hepatocellular; Codon; DNA Adducts; Genes, p53; Humans; Mutagens; Mutation; Rats; Tumor Cells, Cultured | 1998 |
Different frequencies of p53 codon-249 hot-spot mutations in hepatocellular carcinomas in Jiang-su province of China.
Topics: Adult; Aflatoxin B1; Aged; Carcinoma, Hepatocellular; China; Cluster Analysis; DNA Mutational Analysis; DNA, Neoplasm; Female; Food Contamination; Genes, p53; Humans; Liver Neoplasms; Male; Middle Aged; Mutation; Retrospective Studies | 1999 |
Semecarpus anacardium L. nut extract administration induces the in vivo antioxidant defence system in aflatoxin B1 mediated hepatocellular carcinoma.
Topics: Aflatoxin B1; Animals; Antioxidants; Ascorbic Acid; Carcinogens; Carcinoma, Hepatocellular; Cytochrome P-450 Enzyme System; India; Liver Neoplasms, Experimental; Male; Nuts; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Uric Acid; Vitamin E | 1999 |
Evidence that mutational activation of the ras genes may not be involved in aflatoxin B(1)-induced human hepatocarcinogenesis, based on sequence analysis of the ras and p53 genes.
Topics: Aflatoxin B1; Animals; Carcinoma, Hepatocellular; Codon; Gene Expression Regulation, Neoplastic; Genes, p53; Genes, ras; Genetic Predisposition to Disease; Humans; Liver Neoplasms; Mutation; Nucleic Acid Hybridization; Polymerase Chain Reaction; Rats; Sequence Analysis, DNA | 1999 |
Does aflatoxin B1 play a role in the etiology of hepatocellular carcinoma in the United States?
Topics: Adult; Aflatoxin B1; Aged; Carcinogens; Carcinoma, Hepatocellular; DNA Primers; Female; Hepacivirus; Hepatitis B virus; Humans; Immunohistochemistry; Liver Neoplasms; Male; Middle Aged; Polymerase Chain Reaction; Tumor Suppressor Protein p53; United States | 1999 |
[Sequence alterations in p53 gene of hepatocellular carcinoma from high aflatoxin risk area in Guangxi].
Topics: Adult; Aflatoxin B1; Carcinoma, Hepatocellular; Female; Food Microbiology; Genes, p53; Hepatitis B Surface Antigens; Humans; Liver Neoplasms; Male; Middle Aged; Point Mutation; Tumor Suppressor Protein p53; Zea mays | 1997 |
Mutations in the p53 tumor suppressor gene in tree shrew hepatocellular carcinoma associated with hepatitis B virus infection and intake of aflatoxin B1.
Topics: Aflatoxin B1; Amino Acid Sequence; Animals; Base Sequence; Carcinoma, Hepatocellular; Cloning, Molecular; Disease Models, Animal; DNA Mutational Analysis; DNA, Complementary; Genes, Tumor Suppressor; Hepatitis B; Hepatitis B virus; Liver; Liver Neoplasms; Molecular Sequence Data; Mutation; Point Mutation; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Tumor Suppressor Protein p53; Tupaiidae | 2000 |
Activation of the insulin-like growth factor II transcription by aflatoxin B1 induced p53 mutant 249 is caused by activation of transcription complexes; implications for a gain-of-function during the formation of hepatocellular carcinoma.
Topics: Aflatoxin B1; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line; Cell Line, Transformed; DNA-Binding Proteins; Drosophila; Electrophoresis, Polyacrylamide Gel; Gene Expression; Hepatitis B Antigens; Humans; Insulin-Like Growth Factor II; Liver Neoplasms; Mutagenesis; Mutagens; Promoter Regions, Genetic; Sp1 Transcription Factor; TATA-Box Binding Protein; Trans-Activators; Transcription Factors; Transcriptional Activation; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53; Viral Regulatory and Accessory Proteins | 2000 |
[Molecular aspects of hepatocellular carcinoma].
Topics: Adult; Aflatoxin B1; Age Factors; Alcoholism; Animals; Carcinoma, Hepatocellular; Child; Cohort Studies; DNA; DNA Repair; Enzyme Activation; Genes, p53; Growth Substances; Hepatitis B, Chronic; Humans; Liver Cirrhosis; Liver Neoplasms; Marmota; Mice; Mice, Transgenic; Middle Aged; Mutation; Risk Factors; Telomerase | 2000 |
Profile of hepatocellular carcinoma in India: an insight into the possible etiologic associations.
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; DNA, Viral; Female; Genes, p53; Hepacivirus; Hepatitis Antibodies; Hepatitis B virus; Hepatitis B, Chronic; Hepatitis C; Humans; India; Liver Neoplasms; Male; Middle Aged; Risk Factors; RNA, Viral | 2001 |
CTNNB1 mutations and beta-catenin protein accumulation in human hepatocellular carcinomas associated with high exposure to aflatoxin B1.
Topics: Adult; Aflatoxin B1; Aged; beta Catenin; Carcinoma, Hepatocellular; Codon; Cytoskeletal Proteins; DNA Mutational Analysis; Exons; Female; Genes, p53; Humans; Immunohistochemistry; Infant; Liver Neoplasms; Male; Middle Aged; Mutation; Polymorphism, Single-Stranded Conformational; Signal Transduction; Trans-Activators | 2001 |
Aflatoxins and fumonisins in corn from the high-incidence area for human hepatocellular carcinoma in Guangxi, China.
Topics: Aflatoxin B1; Aflatoxins; Carboxylic Acids; Carcinoma, Hepatocellular; China; Food Contamination; Fumonisins; Fusarium; Humans; Incidence; Liver Neoplasms; Mycotoxins; Safety; Zea mays | 2001 |
Associations of plasma aflatoxin B1-albumin adduct level with plasma selenium level and genetic polymorphisms of glutathione S-transferase M1 and T1.
Topics: Adult; Aflatoxin B1; Aged; Aged, 80 and over; Carcinoma, Hepatocellular; Diet; DNA Adducts; Enzyme-Linked Immunosorbent Assay; Female; Genetic Predisposition to Disease; Genotype; Glutathione Transferase; Hepatitis B; Hepatitis B Surface Antigens; Humans; Liver Neoplasms; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Risk Factors; Selenium; Serum Albumin; Sex Factors; Spectrophotometry, Atomic; Taiwan | 2000 |
Identification of homozygous deletions at chromosome 16q23 in aflatoxin B1 exposed hepatocellular carcinoma.
Topics: Aflatoxin B1; Alleles; Carcinogens; Carcinoma, Hepatocellular; Chromosome Deletion; Chromosome Mapping; Chromosomes, Human, Pair 16; Exons; Flow Cytometry; Genes, p53; Genotype; Homozygote; Humans; Liver Neoplasms; Loss of Heterozygosity; Microsatellite Repeats; Models, Genetic; Mutation; RNA, Messenger; Tumor Cells, Cultured | 2001 |
International trends and patterns of primary liver cancer.
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; Cholangiocarcinoma; Female; Hepatitis C, Chronic; Humans; Incidence; Liver Neoplasms; Male; Registries; Time Factors | 2001 |
[The relationship between cyanotoxin (microcystin, MC) in pond-ditch water and primary liver cancer in China].
Topics: Aflatoxin B1; Animals; Animals, Genetically Modified; Carcinoma, Hepatocellular; Child; China; Fresh Water; Glutathione Transferase; Hepatectomy; Humans; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Microcystins; Peptides, Cyclic; Rats; Rats, Inbred F344; Trans-Activators; Viral Regulatory and Accessory Proteins | 2001 |
[p53 gene mutation in hepatocellular carcinoma].
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; DNA Mutational Analysis; DNA, Neoplasm; Environmental Exposure; Hepatitis B; Hepatitis B Surface Antigens; Humans; Liver Neoplasms; Mutation; Polymorphism, Single-Stranded Conformational; Tumor Suppressor Protein p53 | 1998 |
The aflatoxin B(1) formamidopyrimidine adduct plays a major role in causing the types of mutations observed in human hepatocellular carcinoma.
Topics: Aflatoxin B1; Bacteriophage M13; Carcinoma, Hepatocellular; DNA Adducts; DNA, Neoplasm; DNA, Viral; Guanine; Humans; Liver Neoplasms; Molecular Structure; Mutagenesis; Mutagens; Pyrimidines; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2002 |
Epidemiology, risk factors, and natural history of hepatocellular carcinoma.
Topics: Aflatoxin B1; Alcohols; Carcinoma, Hepatocellular; Hepacivirus; Hepatitis B; Hepatitis B virus; Hepatitis C; Humans; Liver Neoplasms; Risk Factors; Viral Hepatitis Vaccines | 2002 |
Aflatoxin and hepatocellular carcinoma: a useful paradigm for environmentally induced carcinogenesis.
Topics: Aflatoxin B1; Animals; Carcinoma, Hepatocellular; Confounding Factors, Epidemiologic; Cytochrome P-450 Enzyme System; Genes, p53; Humans; Liver Neoplasms; Mutation; Smoking | 1992 |
Isolation of a metastasizing cancer cell line from an aflatoxin B1-induced rat liver tumor.
Topics: Aflatoxin B1; Animals; Carcinoma, Hepatocellular; Liver Neoplasms, Experimental; Male; Neoplasm Metastasis; Rats; Rats, Inbred F344; Tumor Cells, Cultured | 1992 |
Risk assessment for aflatoxin B1: a modeling approach.
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; China; Dose-Response Relationship, Drug; Female; Hepatitis B virus; Humans; Liver Neoplasms; Male; Models, Biological; Models, Statistical; Risk Factors | 1992 |
Aflatoxin B1 DNA adducts in smeared tumor tissue from patients with hepatocellular carcinoma.
Topics: Adult; Aflatoxin B1; Aged; Aged, 80 and over; alpha-Fetoproteins; Carcinoma, Hepatocellular; DNA; DNA Adducts; Female; Fluorescein-5-isothiocyanate; Fluorescent Antibody Technique; Fluorescent Dyes; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Humans; Liver Neoplasms; Male; Middle Aged; Phenylenediamines | 1992 |
Ultrastructure of hepatocellular neoplasms in aflatoxin B1 (AFB1)-initiated rainbow trout (Oncorhynchus mykiss).
Topics: Adenoma; Aflatoxin B1; Aflatoxins; Animals; Carcinoma, Hepatocellular; Fish Diseases; Liver; Liver Neoplasms, Experimental; Microscopy, Electron; Trout | 1991 |
Aflatoxin B1-DNA adducts and hepatitis B virus antigens in hepatocellular carcinoma and non-tumorous liver tissue.
Topics: Aflatoxin B1; Carcinoma, Hepatocellular; DNA; Female; Fluorescent Antibody Technique; Hepatitis B Antigens; Humans; Liver; Liver Neoplasms; Male; Middle Aged; Staining and Labeling; Trans-Activators; Viral Regulatory and Accessory Proteins | 1991 |
Hepatic neoplasms in aflatoxin B1-treated, congenital duck hepatitis B virus-infected, and virus-free pekin ducks.
Topics: Aflatoxin B1; Aflatoxins; Amyloidosis; Animals; Carcinoma, Hepatocellular; DNA, Neoplasm; DNA, Viral; Ducks; Female; gamma-Glutamyltransferase; Hepatitis B Virus, Duck; Hepatitis, Viral, Animal; Liver Diseases; Liver Neoplasms; Ovarian Neoplasms; Splenic Diseases | 1990 |
A new method for the quantitation of aflatoxin M1 in urine by high performance liquid chromatography and its application to the etiologic study of hepatoma.
Topics: Aflatoxin B1; Aflatoxin M1; Aflatoxins; Animals; Carcinoma, Hepatocellular; China; Chromatography, High Pressure Liquid; Humans; Liver Neoplasms; Microchemistry; Quality Control; Tupaia | 1990 |
Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1.
Topics: Aflatoxin B1; Aflatoxins; Biotransformation; Carcinoma, Hepatocellular; Cell Line; Cytochrome P-450 Enzyme System; DNA, Neoplasm; Gene Expression; Genetic Vectors; Humans; Kinetics; Liver; Liver Neoplasms; Microsomes, Liver; Protein Binding; Tumor Cells, Cultured; Vaccinia virus | 1990 |
Protective activity of different hepatic cytosolic glutathione S-transferases against DNA-binding metabolites of aflatoxin B1.
Topics: Aflatoxin B1; Aflatoxins; Animals; Carcinogens; Carcinoma, Hepatocellular; Cytosol; DNA; Electrophoresis, Polyacrylamide Gel; Glutathione Transferase; Humans; Isoenzymes; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Mice; Microsomes, Liver; Polychlorinated Biphenyls; Rats; Sodium Dodecyl Sulfate; Trout | 1990 |
Hepatitis B virus, aflatoxins, and hepatocellular carcinoma in southern Guangxi, China.
Topics: Adolescent; Adult; Aflatoxin B1; Aflatoxins; Aged; Carcinoma, Hepatocellular; China; Female; Hepatitis B; Hepatitis B Surface Antigens; Humans; Liver Neoplasms; Male; Middle Aged | 1989 |
Aflatoxin B1 formamidopyrimidine adducts in human hepatocarcinogenesis: a preliminary report.
Topics: Aflatoxin B1; Aflatoxins; Antibodies, Monoclonal; Carcinogens; Carcinoma, Hepatocellular; DNA; DNA, Neoplasm; Humans; Immunoblotting; Liver Neoplasms; Pyrimidines | 1989 |
Immunoassay procedures to detect exposure to aflatoxin B1 and benzo(a)pyrene in animals and man at the DNA level.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Hepatocellular; DNA; Enzyme-Linked Immunosorbent Assay; Humans; Liver; Liver Neoplasms; Lung; Male; Rats; Rats, Inbred Strains | 1988 |
Risk factors for hepatocellular carcinoma in Guangxi, People's Republic of China.
Topics: Aflatoxin B1; Aflatoxins; Carcinoma, Hepatocellular; China; Food Contamination; Hepatitis B; Hepatitis B Surface Antigens; Humans; Liver Cirrhosis; Liver Neoplasms; Risk | 1985 |
Interaction of aflatoxin and hepatitis B virus in the pathogenesis of hepatocellular carcinoma.
Topics: Aflatoxin B1; Aflatoxins; Carcinoma, Hepatocellular; DNA, Neoplasm; DNA, Viral; Hepatitis B; Hepatitis B virus; Humans; Liver Neoplasms; Models, Biological | 1986 |
[Respective roles of aflatoxin and hepatitis B in the etiology of primary cancer of the liver in man].
Topics: Adenoma, Bile Duct; Adolescent; Adult; Aflatoxin B1; Aflatoxins; Age Factors; Aged; Aged, 80 and over; Carcinoma, Hepatocellular; Child; Child, Preschool; Female; Hepatitis B; Humans; Liver Neoplasms; Male; Middle Aged; Sex Factors | 1986 |
Aflatoxin exposure measured by urinary excretion of aflatoxin B1-guanine adduct and hepatitis B virus infection in areas with different liver cancer incidence in Kenya.
Topics: Aflatoxin B1; Aflatoxins; Carcinoma, Hepatocellular; DNA Damage; Female; Guanine; Hepatitis B; Hepatitis B Surface Antigens; Humans; Kenya; Liver Neoplasms; Male; Sex Factors | 1987 |
Aflatoxin, viral hepatitis and primary liver cancer.
Topics: Adenoma, Bile Duct; Aflatoxin B1; Aflatoxins; Carcinogens; Carcinoma, Hepatocellular; Female; Hepatitis B; Hepatitis B Surface Antigens; Humans; Liver Neoplasms; Male; Middle Aged | 1987 |