afimoxifene and Uterine-Cervical-Neoplasms

Growth of the human squamous cervical carcinoma cell line, HOG-I, was stimulated in response to oestradiol in serum-containing and chemically defined medium. The oestradiol-stimulated growth could be inhibited by 4-OH tamoxifen, progesterone and medroxyprogesterone acetate; the last 2 compounds also inhibited basal cell growth in serum-containing and chemically defined media. The data are consistent with the sensitivity of human squamous cervical cancer to sex-steroid hormones and suggest that endocrine therapies may be of benefit in this disease.

Topics: Adult; Carcinoma, Squamous Cell; Cell Division; Culture Media; Estradiol; Female; Humans; Medroxyprogesterone; Medroxyprogesterone Acetate; Tamoxifen; Tumor Cells, Cultured; Uterine Cervical Neoplasms