afimoxifene has been researched along with Insulinoma* in 1 studies
1 other study(ies) available for afimoxifene and Insulinoma
| Article | Year |
|---|---|
Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.
To explore the role of c-Myc in carcinogenesis, we have developed a reversible transgenic model of pancreatic beta cell oncogenesis using a switchable form of the c-Myc protein. Activation of c-Myc in adult, mature beta cells induces uniform beta cell proliferation but is accompanied by overwhelming apoptosis that rapidly erodes beta cell mass. Thus, the oncogenic potential of c-Myc in beta cells is masked by apoptosis. Upon suppression of c-Myc-induced beta cell apoptosis by coexpression of Bcl-x(L), c-Myc triggers rapid and uniform progression into angiogenic, invasive tumors. Subsequent c-Myc deactivation induces rapid regression associated with vascular degeneration and beta cell apoptosis. Our data indicate that highly complex neoplastic lesions can be both induced and maintained in vivo by a simple combination of two interlocking molecular lesions. Topics: 3T3 Cells; Animals; Apoptosis; bcl-X Protein; Cadherins; Cell Division; Cell Line; Cell Nucleus; Estrogen Antagonists; Genes, myc; Humans; Insulinoma; Islets of Langerhans; Mice; Mice, Inbred Strains; Mice, Transgenic; Mutation; Pancreatic Neoplasms; Promoter Regions, Genetic; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Receptors, Estrogen; Tamoxifen | 2002 |