adriamycin-aglycone has been researched along with Kidney-Neoplasms* in 1 studies
1 other study(ies) available for adriamycin-aglycone and Kidney-Neoplasms
Article | Year |
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Occurrence of circulating 7-deoxyaglycone metabolites of 4'-deoxydoxorubicin in man.
In five cancer patients we have determined the pharmacokinetics of 4'-deoxydoxorubicin (4'-DOX), its alcoholic metabolite 4'-deoxydoxorubicinol and the occurrence of circulating 7-deoxyaglycone metabolites. The 7-deoxyaglycone of the alcohol metabolite, the major aglycone of Adriamycin (ADR) present in man, was not detected in any serum sample. The 7-deoxyaglycone of the parent drug, which appears in concentrations in excess of 30 ng/ml after ADR administration, was detected in only 2/5 patients in trace amounts. These preliminary data indicate a difference in biotransformation between ADR and 4'-DOX despite their close structural similarities. Topics: Biotransformation; Chromatography, High Pressure Liquid; Doxorubicin; Female; Half-Life; Humans; Kidney Neoplasms; Male; Naphthacenes | 1987 |