adriamycin-aglycone and Kidney-Neoplasms

adriamycin-aglycone has been researched along with Kidney-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for adriamycin-aglycone and Kidney-Neoplasms

ArticleYear
Occurrence of circulating 7-deoxyaglycone metabolites of 4'-deoxydoxorubicin in man.
    Cancer chemotherapy and pharmacology, 1987, Volume: 20, Issue:3

    In five cancer patients we have determined the pharmacokinetics of 4'-deoxydoxorubicin (4'-DOX), its alcoholic metabolite 4'-deoxydoxorubicinol and the occurrence of circulating 7-deoxyaglycone metabolites. The 7-deoxyaglycone of the alcohol metabolite, the major aglycone of Adriamycin (ADR) present in man, was not detected in any serum sample. The 7-deoxyaglycone of the parent drug, which appears in concentrations in excess of 30 ng/ml after ADR administration, was detected in only 2/5 patients in trace amounts. These preliminary data indicate a difference in biotransformation between ADR and 4'-DOX despite their close structural similarities.

    Topics: Biotransformation; Chromatography, High Pressure Liquid; Doxorubicin; Female; Half-Life; Humans; Kidney Neoplasms; Male; Naphthacenes

1987