adrenomedullin and Vitreoretinopathy--Proliferative

To investigate the expression of adrenomedullin (ADM) and ADM receptor (ADMR) in epiretinal membranes (ERM) of proliferative vitreoretinopathy (PVR).. The expression of ADM and ADMR in 10 ERM were studied by in situ hybridization analysis (ISH).. ADM and ADMR mRNAs were expressed in 7 of 10 specimens. The positive signals were distributed unevenly in positive cells. Some cells expressed mainly in the cytoplasm and the others expressed mainly in the nucleus.. ADM and ADMR are expressed in the ERM of PVR, indicating that ADM and ADMR may play a role in the pathogenesis of PVR.

Topics: Adrenomedullin; Humans; Receptors, Adrenomedullin; Receptors, Peptide; Retina; RNA, Messenger; Vitreoretinopathy, Proliferative

To clarify possible involvement of adrenomedullin in the pathophysiology of inflammation of eyes, we measured immunoreactive-adrenomedullin concentrations in the aqueous humor and plasma obtained from 14 control subjects and 56 patients with uveitis or vitreoretinal disorders. Immunoreactive-adrenomedullin levels in the aqueous humor were significantly elevated in patients with active uveitis, proliferative vitreoretinopathy and proliferative diabetic retinopathy, as compared with control subjects. The plasma immunoreactive-adrenomedullin levels were not significantly correlated with the aqueous humor levels. These findings suggest that adrenomedullin produced locally in the eyes is involved in the pathophysiology of uveitis and some proliferative vitreoretinal disorders.

Topics: Adrenomedullin; Adult; Aged; Aqueous Humor; Calcitonin Gene-Related Peptide; Diabetic Retinopathy; Female; Humans; Male; Middle Aged; Peptides; Uveitis; Vitreoretinopathy, Proliferative

To explore the possible involvement of adrenomedullin in the pathophysiology of proliferative vitreoretinopathy.. The radioimmunoassay technique was used to determine immunoreactive adrenomedullin concentrations in the vitreous fluid from 41 eyes of 41 patients undergoing vitrectomy for a variety of retinal conditions, including proliferative vitreoretinopathy, proliferative diabetic retinopathy, age-related macular degeneration, and macular hole.. Immunoreactive adrenomedullin levels in the vitreous of patients with proliferative vitreoretinopathy were significantly higher than those of patients with proliferative diabetic retinopathy (P < .005), age-related macular degeneration (P < .001), and macular hole (P < .0001).. Adrenomedullin may be involved in the pathophysiology of proliferative vitreoretinopathy.

Topics: Adrenomedullin; Diabetic Retinopathy; Female; Humans; Macular Degeneration; Male; Middle Aged; Peptides; Radioimmunoassay; Retinal Perforations; Vasodilator Agents; Vitrectomy; Vitreoretinopathy, Proliferative; Vitreous Body