adrenomedullin and Respiratory-Distress-Syndrome--Newborn

Delivery room (DR) management may play an important role in the development and prevention of lung injury. Therefore, in a cohort of low birth weight infants (LBW), we investigated the effects of two different lung recruitment maneuvers, such as positive pressure ventilation (PPV) and sustained inflation (SI) on adrenomedullin (AM), a well-established lung-specific vasoactive agent.. This is a prospective case-control randomized study in 44 LBW infants spontaneously breathing with respiratory failure at birth requiring respiratory support. LBW were randomized to receive PPV (. No significant differences in AM (. The present data, showing the absence of any differences in AM blood and urine levels, suggest that PPV and SI are both feasible and equally effective DR maneuvers. The findings open the way to further studies evaluating the effects of PPV and SI on short-/long-term respiratory outcome through biomarkers assessment.

Topics: Adrenomedullin; Biomarkers; Case-Control Studies; Continuous Positive Airway Pressure; Female; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant, Premature; Male; Positive-Pressure Respiration; Prospective Studies; Respiratory Distress Syndrome, Newborn; Respiratory Insufficiency