adrenomedullin and Pulmonary-Edema

adrenomedullin has been researched along with Pulmonary-Edema* in 2 studies

Other Studies

2 other study(ies) available for adrenomedullin and Pulmonary-Edema

Article	Year
A role for adrenomedullin in the pathogenesis of alveolar edema. Critical care (London, England), 2006, Volume: 10, Issue:4 Topics: Adrenomedullin; Humans; Nitric Oxide; Peptides; Pulmonary Edema	2006
Adrenomedullin reduces endothelial hyperpermeability. Circulation research, 2002, Oct-04, Volume: 91, Issue:7 Endothelial hyperpermeability induced by inflammatory mediators is a hallmark of sepsis and adult respiratory distress syndrome. Increased levels of the regulatory peptide adrenomedullin (ADM) have been found in patients with systemic inflammatory response. We analyzed the effect of ADM on the permeability of cultured human umbilical vein endothelial cell (HUVEC) and porcine pulmonary artery endothelial cell monolayers. ADM dose-dependently reduced endothelial hyperpermeability induced by hydrogen peroxide (H2O2), thrombin, and Escherichia coli hemolysin. Moreover, ADM pretreatment blocked H2O2-related edema formation in isolated perfused rabbit lungs and increased cAMP levels in lung perfusate. ADM bound specifically to HUVECs and porcine pulmonary artery endothelial cells and increased cellular cAMP levels. Simultaneous inhibition of cAMP-degrading phosphodiesterase isoenzymes 3 and 4 potentiated ADM-dependent cAMP accumulation and synergistically enhanced ADM-dependent reduction of thrombin-induced hyperpermeability. However, ADM showed no effect on endothelial cGMP content, basal intracellular Ca2+ levels, or the H2O2-stimulated, thrombin-stimulated, or Escherichia coli hemolysin-stimulated Ca2+ increase. ADM diminished thrombin- and H2O2-related myosin light chain phosphorylation as well as stimulus-dependent stress fiber formation and gap formation in HUVECs, suggesting that ADM may stabilize the barrier function by cAMP-dependent relaxation of the microfilament system. These findings identify a new function of ADM and point to ADM as a potential interventional agent for the reduction of vascular leakage in sepsis and adult respiratory distress syndrome. Topics: Actin Cytoskeleton; Adrenomedullin; Animals; Calcium; Cell Membrane Permeability; Cells, Cultured; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Hydrogen Peroxide; Lung; Myosin Light Chains; Peptides; Phosphorylation; Pulmonary Edema; Rabbits; Swine	2002

Article

Year

A role for adrenomedullin in the pathogenesis of alveolar edema.

Critical care (London, England), 2006, Volume: 10, Issue:4

Topics: Adrenomedullin; Humans; Nitric Oxide; Peptides; Pulmonary Edema

2006

Adrenomedullin reduces endothelial hyperpermeability.

Circulation research, 2002, Oct-04, Volume: 91, Issue:7

Endothelial hyperpermeability induced by inflammatory mediators is a hallmark of sepsis and adult respiratory distress syndrome. Increased levels of the regulatory peptide adrenomedullin (ADM) have been found in patients with systemic inflammatory response. We analyzed the effect of ADM on the permeability of cultured human umbilical vein endothelial cell (HUVEC) and porcine pulmonary artery endothelial cell monolayers. ADM dose-dependently reduced endothelial hyperpermeability induced by hydrogen peroxide (H2O2), thrombin, and Escherichia coli hemolysin. Moreover, ADM pretreatment blocked H2O2-related edema formation in isolated perfused rabbit lungs and increased cAMP levels in lung perfusate. ADM bound specifically to HUVECs and porcine pulmonary artery endothelial cells and increased cellular cAMP levels. Simultaneous inhibition of cAMP-degrading phosphodiesterase isoenzymes 3 and 4 potentiated ADM-dependent cAMP accumulation and synergistically enhanced ADM-dependent reduction of thrombin-induced hyperpermeability. However, ADM showed no effect on endothelial cGMP content, basal intracellular Ca2+ levels, or the H2O2-stimulated, thrombin-stimulated, or Escherichia coli hemolysin-stimulated Ca2+ increase. ADM diminished thrombin- and H2O2-related myosin light chain phosphorylation as well as stimulus-dependent stress fiber formation and gap formation in HUVECs, suggesting that ADM may stabilize the barrier function by cAMP-dependent relaxation of the microfilament system. These findings identify a new function of ADM and point to ADM as a potential interventional agent for the reduction of vascular leakage in sepsis and adult respiratory distress syndrome.

Topics: Actin Cytoskeleton; Adrenomedullin; Animals; Calcium; Cell Membrane Permeability; Cells, Cultured; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Hydrogen Peroxide; Lung; Myosin Light Chains; Peptides; Phosphorylation; Pulmonary Edema; Rabbits; Swine

2002