adrenocorticotropin-zinc and Hypopituitarism

Topics: ACTH Syndrome, Ectopic; Addison Disease; Adrenocorticotropic Hormone; Corticotropin-Releasing Hormone; Cosyntropin; Cushing Syndrome; Delayed-Action Preparations; Dexamethasone; Evaluation Studies as Topic; Humans; Hypopituitarism; Immunoradiometric Assay; Nelson Syndrome; Reagent Kits, Diagnostic; Reproducibility of Results; Sensitivity and Specificity

We present the endocrine parameters of two adult patients with partial hypopituitarism documented at 6 and 8 months after chemotherapy, single fraction total body irradiation (10.5 Gy) and autologous bone marrow transplantation. The hormone profiles demonstrate severe somatotroph insufficiency and impaired adrenocorticotroph secretory capacity, despite sparing of the gonadotroph compartment. We recommend stimulatory testing of hypothalamic-pituitary function from 3 months post-transplant, as basal hormonal concentrations may be equivocal, and supplementation may significantly improve quality of life.

Topics: Adult; Bone Marrow Transplantation; Cosyntropin; Hormones; Humans; Hydrocortisone; Hypopituitarism; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radioimmunoassay; Transplantation, Autologous; Whole-Body Irradiation

Topics: Adrenal Cortex; Adrenal Cortex Function Tests; Adult; Aldosterone; Cosyntropin; Female; Humans; Hypopituitarism; Male; Metoclopramide; Middle Aged; Pituitary Gland, Anterior