adozelesin has been researched along with Leukemia-P388* in 1 studies
1 other study(ies) available for adozelesin and Leukemia-P388
| Article | Year |
|---|---|
Stereoelectronic factors influencing the biological activity and DNA interaction of synthetic antitumor agents modeled on CC-1065.
The synthesis, physicochemical properties, and biological activities of a series of novel spiro cyclopropyl compounds, modeled on the potent antitumor antibiotic CC-1065 (1), are described. Many of these synthetic analogues are significantly more effective than 1 against murine tumors. In particular, compound 27 exhibits high activity and potency. Structure-activity analysis supports a molecular mechanism for biological action involving hydrophobic interaction of the drug with DNA and acid-catalyzed alkylation of DNA. Topics: Animals; Antibiotics, Antineoplastic; Chemical Phenomena; Chemistry, Physical; Circular Dichroism; DNA; Duocarmycins; Female; Indoles; Leucomycins; Leukemia L1210; Leukemia P388; Mice; Mice, Inbred DBA; Solubility | 1988 |