Page last updated: 2024-10-16

adipic acid and Acute Hepatic Failure

adipic acid has been researched along with Acute Hepatic Failure in 1 studies

adipic acid : An alpha,omega-dicarboxylic acid that is the 1,4-dicarboxy derivative of butane.

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rudnick, DA1
Dietzen, DJ1
Turmelle, YP1
Shepherd, R1
Zhang, S1
Belle, SH1
Squires, R1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Multi-Center Group to Study Acute Liver Failure in Children[NCT00986648]158 participants (Actual)Observational2000-01-31Completed
A Multi-center Study of the Safety and Efficacy of N-acetylcysteine in the Treatment of Acute Liver Failure in Pediatric Patients Not Caused by Acetaminophen.[NCT00248625]Phase 3184 participants (Actual)Interventional2000-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Cumulative Percent Incidence of Transplantation by 1 Year

(NCT00248625)
Timeframe: Within 1 year of randomization

Interventionpercentage of participants (Number)
N-acetylcysteine (NAC)45
Placebo35

Infectious Complication

(NCT00248625)
Timeframe: Within 7 days of randomization

InterventionParticipants (Number)
N-acetylcysteine (NAC)20
Placebo21

Length of Hospital Stay

(NCT00248625)
Timeframe: Randomization to hospital discharge

Interventiondays (Median)
N-acetylcysteine (NAC)103
Placebo21

Spontaneous Recovery

Survival without liver transplantation (NCT00248625)
Timeframe: One year following randomization

Interventionparticipants (Number)
N-acetylcysteine (NAC)33
Placebo49

Survival

Spontaneous survival without transplant plus survival following transplantation (NCT00248625)
Timeframe: One year following randomization

InterventionParticipants (Number)
N-acetylcysteine (NAC)68
Placebo76

Categorized Length of ICU Stay

The length of ICU stay was categorized as number of days in ICU within 7 days of randomization, unless participant either died or received an LTx within this time period. Special categories were created for these cases. (NCT00248625)
Timeframe: Within 7 days of randomization

,
Interventionparticipants (Number)
0 days1 day2 days3 days4 days5 days6 days7 daysunderwent LTx w/i 7 days of randomizationdied w/o LTx w/i 7 days of randomization
N-acetylcysteine (NAC)293321459288
Placebo3444033314225

Highest Coma Grade of Hepatic Encephalopathy

West Haven Criteria for hepatic encephalopathy (Grade 0 - IV ) is used for participants > 3 year of age. Coma grade IV indicates a participant who is comatose , with no reflexes, is decerebrate and has abnormal EEG changes with very slow delta activity. For participants less than 3 years the Whittington Scale was used. The Whittington scale does not use EEG changes and has only 3 levels, early (grades I and II), Mid (III) with somnolence, stupor, combativeness and Late (IV) for participants who are comatose with absent reflexes and decerebrate or decorticate posturing. (NCT00248625)
Timeframe: Within 7 days of randomization

,
Interventionparticipants (Number)
0IIIIIIIV
N-acetylcysteine (NAC)2816201511
Placebo272119176

Number of Organ Systems Failing

(NCT00248625)
Timeframe: Within 7 days of randomization

,
Interventionparticipants (Number)
01234
N-acetylcysteine (NAC)442115111
Placebo46231283

Other Studies

1 other study available for adipic acid and Acute Hepatic Failure

ArticleYear
Serum alpha-NH-butyric acid may predict spontaneous survival in pediatric acute liver failure.
    Pediatric transplantation, 2009, Volume: 13, Issue:2

    Topics: Adipates; Adolescent; Animals; Biomarkers; Butyric Acid; Child; Child, Preschool; Female; Hepatectom

2009
Serum alpha-NH-butyric acid may predict spontaneous survival in pediatric acute liver failure.
    Pediatric transplantation, 2009, Volume: 13, Issue:2

    Topics: Adipates; Adolescent; Animals; Biomarkers; Butyric Acid; Child; Child, Preschool; Female; Hepatectom

2009
Serum alpha-NH-butyric acid may predict spontaneous survival in pediatric acute liver failure.
    Pediatric transplantation, 2009, Volume: 13, Issue:2

    Topics: Adipates; Adolescent; Animals; Biomarkers; Butyric Acid; Child; Child, Preschool; Female; Hepatectom

2009
Serum alpha-NH-butyric acid may predict spontaneous survival in pediatric acute liver failure.
    Pediatric transplantation, 2009, Volume: 13, Issue:2

    Topics: Adipates; Adolescent; Animals; Biomarkers; Butyric Acid; Child; Child, Preschool; Female; Hepatectom

2009