adipic acid has been researched along with Acute Hepatic Failure in 1 studies
adipic acid : An alpha,omega-dicarboxylic acid that is the 1,4-dicarboxy derivative of butane.
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (100.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Rudnick, DA | 1 |
Dietzen, DJ | 1 |
Turmelle, YP | 1 |
Shepherd, R | 1 |
Zhang, S | 1 |
Belle, SH | 1 |
Squires, R | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
A Multi-Center Group to Study Acute Liver Failure in Children[NCT00986648] | 158 participants (Actual) | Observational | 2000-01-31 | Completed | |||
A Multi-center Study of the Safety and Efficacy of N-acetylcysteine in the Treatment of Acute Liver Failure in Pediatric Patients Not Caused by Acetaminophen.[NCT00248625] | Phase 3 | 184 participants (Actual) | Interventional | 2000-01-31 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
(NCT00248625)
Timeframe: Within 1 year of randomization
Intervention | percentage of participants (Number) |
---|---|
N-acetylcysteine (NAC) | 45 |
Placebo | 35 |
(NCT00248625)
Timeframe: Within 7 days of randomization
Intervention | Participants (Number) |
---|---|
N-acetylcysteine (NAC) | 20 |
Placebo | 21 |
(NCT00248625)
Timeframe: Randomization to hospital discharge
Intervention | days (Median) |
---|---|
N-acetylcysteine (NAC) | 103 |
Placebo | 21 |
Survival without liver transplantation (NCT00248625)
Timeframe: One year following randomization
Intervention | participants (Number) |
---|---|
N-acetylcysteine (NAC) | 33 |
Placebo | 49 |
Spontaneous survival without transplant plus survival following transplantation (NCT00248625)
Timeframe: One year following randomization
Intervention | Participants (Number) |
---|---|
N-acetylcysteine (NAC) | 68 |
Placebo | 76 |
The length of ICU stay was categorized as number of days in ICU within 7 days of randomization, unless participant either died or received an LTx within this time period. Special categories were created for these cases. (NCT00248625)
Timeframe: Within 7 days of randomization
Intervention | participants (Number) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
0 days | 1 day | 2 days | 3 days | 4 days | 5 days | 6 days | 7 days | underwent LTx w/i 7 days of randomization | died w/o LTx w/i 7 days of randomization | |
N-acetylcysteine (NAC) | 29 | 3 | 3 | 2 | 1 | 4 | 5 | 9 | 28 | 8 |
Placebo | 34 | 4 | 4 | 0 | 3 | 3 | 3 | 14 | 22 | 5 |
West Haven Criteria for hepatic encephalopathy (Grade 0 - IV ) is used for participants > 3 year of age. Coma grade IV indicates a participant who is comatose , with no reflexes, is decerebrate and has abnormal EEG changes with very slow delta activity. For participants less than 3 years the Whittington Scale was used. The Whittington scale does not use EEG changes and has only 3 levels, early (grades I and II), Mid (III) with somnolence, stupor, combativeness and Late (IV) for participants who are comatose with absent reflexes and decerebrate or decorticate posturing. (NCT00248625)
Timeframe: Within 7 days of randomization
Intervention | participants (Number) | ||||
---|---|---|---|---|---|
0 | I | II | III | IV | |
N-acetylcysteine (NAC) | 28 | 16 | 20 | 15 | 11 |
Placebo | 27 | 21 | 19 | 17 | 6 |
(NCT00248625)
Timeframe: Within 7 days of randomization
Intervention | participants (Number) | ||||
---|---|---|---|---|---|
0 | 1 | 2 | 3 | 4 | |
N-acetylcysteine (NAC) | 44 | 21 | 15 | 11 | 1 |
Placebo | 46 | 23 | 12 | 8 | 3 |
1 other study available for adipic acid and Acute Hepatic Failure
Article | Year |
---|---|
Serum alpha-NH-butyric acid may predict spontaneous survival in pediatric acute liver failure.
Topics: Adipates; Adolescent; Animals; Biomarkers; Butyric Acid; Child; Child, Preschool; Female; Hepatectom | 2009 |
Serum alpha-NH-butyric acid may predict spontaneous survival in pediatric acute liver failure.
Topics: Adipates; Adolescent; Animals; Biomarkers; Butyric Acid; Child; Child, Preschool; Female; Hepatectom | 2009 |
Serum alpha-NH-butyric acid may predict spontaneous survival in pediatric acute liver failure.
Topics: Adipates; Adolescent; Animals; Biomarkers; Butyric Acid; Child; Child, Preschool; Female; Hepatectom | 2009 |
Serum alpha-NH-butyric acid may predict spontaneous survival in pediatric acute liver failure.
Topics: Adipates; Adolescent; Animals; Biomarkers; Butyric Acid; Child; Child, Preschool; Female; Hepatectom | 2009 |