adenosine-kinase and Sclerosis

adenosine-kinase has been researched along with Sclerosis* in 2 studies

Other Studies

2 other study(ies) available for adenosine-kinase and Sclerosis

ArticleYear
Ectopic expression of neuronal adenosine kinase, a biomarker in mesial temporal lobe epilepsy without hippocampal sclerosis.
    Neuropathology and applied neurobiology, 2023, Volume: 49, Issue:4

    Mesial temporal lobe epilepsy without hippocampal sclerosis (no-HS MTLE) refers to those MTLE patients who have neither magnetic resonance imaging (MRI) lesions nor definite pathological evidence of hippocampal sclerosis. They usually have resistance to antiepileptic drugs, difficulties in precise seizure location and poor surgical outcomes. Adenosine is a neuroprotective neuromodulator that acts as a seizure terminator in the brain. The role of adenosine in no-HS MTLE is still unclear. Further research to explore the aetiology and pathogenesis of no-HS MTLE may help to find new therapeutic targets.. In surgically resected hippocampal specimens, we examined the maladaptive changes of the adenosine system of patients with no-HS MTLE. In order to better understand the dysregulation of the adenosine pathway in no-HS MTLE, we developed a rat model based on the induction of focal cortical lesions through a prenatal freeze injury.. We first examined the adenosine system in no-HS MTLE patients who lack hippocampal neuronal loss and found ectopic expression of the astrocytic adenosine metabolising enzyme adenosine kinase (ADK) in hippocampal pyramidal neurons, as well as downregulation of neuronal A. Ectopic expression of neuronal ADK might be a pathological hallmark of no-HS MTLE. Maladaptive changes in adenosine metabolism might be a novel target for therapeutic intervention in no-HS MTLE.

    Topics: Adenosine Kinase; Animals; Biomarkers; Ectopic Gene Expression; Epilepsy, Temporal Lobe; Hippocampal Sclerosis; Hippocampus; Magnetic Resonance Imaging; Rats; Sclerosis; Seizures

2023
Adenosine kinase and adenosine receptors A
    Epilepsia, 2020, Volume: 61, Issue:4

    In 75 cases, patients were stratified into high-risk (n = 16), medium-risk (n = 11) and low-risk (n = 48) categories according to the frequency of generalized seizures before surgery. Using whole-slide scanning Definiens image analysis we quantified the labeling index (LI) for ADK, A. A. Reduced cortical A

    Topics: Adenosine Kinase; Adult; Epilepsy, Temporal Lobe; Female; Hippocampus; Humans; Male; Receptor, Adenosine A1; Receptor, Adenosine A2A; Risk Factors; Sclerosis; Sudden Unexpected Death in Epilepsy

2020