adenosine-kinase has been researched along with Renal-Insufficiency--Chronic* in 1 studies
1 review(s) available for adenosine-kinase and Renal-Insufficiency--Chronic
| Article | Year |
|---|---|
The effect of energy restriction on development and progression of chronic kidney disease: review of the current evidence.
Energy restriction (ER) has anti-ageing effects and probably protects from a range of chronic diseases including cancer, diabetes and chronic kidney disease (CKD). Specifically, ER has a positive impact on experimental kidney ageing, CKD (diabetic nephropathy, polycystic kidney disease) and acute kidney injury (nephrotoxic, ischaemia-reperfusion injury) through such mechanisms as increased autophagy, mitochondrial biogenesis and DNA repair, and decreased inflammation and oxidative stress. Key molecules contributing to ER-mediated kidney protection include adenosine monophosphate-activated protein kinase, sirtuin-1 and PPAR-γ coactivator 1α. However, CKD is a complex condition, and ER may potentially worsen CKD complications such as protein-energy wasting, bone-mineral disorders and impaired wound healing. ER mimetics are drugs, such as metformin and Na-glucose co-transporter-2 which mimic the action of ER. This review aims to provide comprehensive data regarding the effect of ER on CKD progression and outcomes. Topics: Adenosine Kinase; Animals; Caloric Restriction; Disease Progression; DNA Repair; Energy Intake; Humans; Kidney; Organelle Biogenesis; Oxidative Stress; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Protective Factors; Renal Insufficiency, Chronic; Sirtuin 1 | 2021 |