adenosine-kinase has been researched along with Hypothyroidism* in 2 studies
2 other study(ies) available for adenosine-kinase and Hypothyroidism
| Article | Year |
|---|---|
Changes in the activities of adenosine-metabolizing enzymes in six regions of the rat brain on chemical induction of hypothyroidism.
1. Rats (4 weeks old) were made hypothyroid by treatment with propylthiouracil and a low-iodine diet for a further period of 4 weeks. Synaptosomal membranes, myelin and 105,000 g soluble fractions were obtained from six regions of the brain. 2. Hypothyroidism resulted in 2-5-fold increases in membrane-bound 5'-nucleotidase activity in synaptosomal fractions obtained from cerebellum, cortex, striatum and hippocampus. By contrast, myelin 5'-nucleotidase activity was slightly increased only in the medulla oblongata. 3. Hypothyroidism did not change adenosine deaminase activity, but decreased adenosine kinase activity by approx. 40% in soluble fractions obtained from cerebellum, hippocampus, striatum and hypothalamus. 4. It is suggested that these changes in hypothyroidism, in particular the increases in 5'-nucleotidase activity, could enhance the neuromodulatory effect of adenosine to decrease neurotransmitter release. Topics: 5'-Nucleotidase; Adenosine Deaminase; Adenosine Kinase; Animals; Brain; Hypothyroidism; Male; Nucleoside Deaminases; Nucleotidases; Phosphotransferases; Propylthiouracil; Rats; Rats, Inbred Strains; Synaptosomes | 1989 |
Enzymes involved in adenosine metabolism in rat white and brown adipocytes. Effects of streptozotocin-diabetes, hypothyroidism, age and sex differences.
1. Adipocytes were isolated from epididymal white fat and interscapular brown fat of male rats, and activities of 5'-nucleotidase, adenosine deaminase and adenosine kinase were measured in cell extracts. 2. 5'-Nucleotidase activity in white adipocytes was increased in streptozotocin-diabetes, decreased in hypothyroidism and increased with age. That activity in brown adipocytes was unchanged in diabetes, decreased in hypothyroidism and increased with age. 5'-Nucleotidase activity was higher in white adipocytes from female rats. 3. Adenosine deaminase activity in white adipocytes was increased in diabetes, decreased in hypothyroidism and increased with age. That activity in brown adipocytes was decreased in diabetes and hypothyroidism. 4. Adenosine kinase activity in both cell types was unchanged in diabetes or hypothyroidism, but increased with age. Topics: 5'-Nucleotidase; Adenosine; Adenosine Deaminase; Adenosine Kinase; Adipose Tissue; Adipose Tissue, Brown; Age Factors; Animals; Diabetes Mellitus, Experimental; Hypothyroidism; In Vitro Techniques; Male; Nucleotidases; Rats; Rats, Inbred Strains; Sex Factors | 1987 |