adenosine has been researched along with Rheumatoid Arthritis in 68 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (5.88) | 18.7374 |
| 1990's | 11 (16.18) | 18.2507 |
| 2000's | 24 (35.29) | 29.6817 |
| 2010's | 21 (30.88) | 24.3611 |
| 2020's | 8 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, C; Li, J; Li, XF; Wu, S; Wu, YY; Yin, SQ | 1 |
| Chen, J; Lin, X; Tao, C; Wang, Q; Zhang, M; Zhang, R | 1 |
| Cai, X; Wang, R; Xiao, J; Ye, Z; Zhou, W | 1 |
| Cheng, T; Li, XF; Liu, J; Qiao, J; Song, S; Zhang, SX; Zhao, R | 1 |
| Hu, Z; Huang, C; Liu, J; Sun, G; Wan, L; Wang, K; Zhu, L; Zhu, Z | 1 |
| Cao, X; Deng, T; Fan, D; Geng, Q; Gu, X; Wang, Z; Xiao, C; Zhang, M; Zhang, Q | 1 |
| Bernardes, VM; da Silva, JLG; Leal, DBR; Passos, DF | 1 |
| Gallo, A; Gatsiou, A; Sfikakis, PP; Silvestris, DA; Stamatelopoulos, K; Stellos, K; Tektonidou, MG; Vlachogiannis, NI | 1 |
| Damnjanovic, T; Jekic, B; Maksimovic, N | 1 |
| Bedoui, Y; Gasque, P; Giry, C; Guillot, X; Guiraud, P; Jaffar-Bandjee, MC; Ralandison, S; Sélambarom, J | 1 |
| Deb, PK | 1 |
| Acosta Rodríguez, EV; Acosta, CDV; Amezcua Vesely, MC; Bossio, SN; Cadile, I; Ferrero, PV; Gruppi, A; Montes, CL; Mussano, E; Onetti, L; Ponce, NE; Zacca, ER | 1 |
| Borea, PA; Bortoluzzi, A; Gessi, S; Govoni, M; Merighi, S; Padovan, M; Pasquini, S; Ravani, A; Varani, K; Vincenzi, F | 1 |
| Benko, M; Bismuth, G; Blüml, S; Burkard, TR; Cavaco-Paulo, A; Charvet, C; Feuillet, V; Fischer, MB; Huppa, JB; Lager, F; Le Roux, D; Leksa, V; Machacek, C; Matsuyama, T; Mitulovic, G; Ohradanova-Repic, A; Platzer, R; Renault, G; Stockinger, H; Suchanek, M; Zlabinger, GJ | 1 |
| Colello, J; Dang, J; Fu, Q; Gu, J; Huang, F; Kandalam, U; Luo, Y; Wang, J; Wu, W; Xue, Y; Yuan, J; Zhang, X; Zheng, SG; Zheng, Y | 1 |
| Ahmed, S; Bandopadhyay, S; Bandyopadhyay, N; Pal, RS; Pal, Y | 1 |
| Almasri, IM; Kaur, A; Naik, RR; Shakya, AK | 1 |
| Dzierzbicka, K; Samsel, M; Trzonkowski, P | 1 |
| Almeida, SL; Alves-Filho, JC; Carregaro, V; Costa, DL; Cunha, FQ; Cunha, TM; Demarque, DP; Donate, PB; Ferreira, FI; Ferreira, SH; Figueiredo, F; França, RF; Gouvea, DR; Liew, FY; Lopes, NP; Louzada-Junior, P; Oliveira, RD; Peres, RS; Pinto, LG; Queiroz, RH; Silva, JS; Talbot, J | 1 |
| Brown, PM; Isaacs, JD; Pratt, AG | 1 |
| Amital, H; Bar-Yehuda, S; Barer, F; Cohen, S; Del Valle, L; Fishman, P; Gao, ZG; Jacobson, KA; Joshi, BV; Ochaion, A; Patoka, R; Perez-Liz, G | 1 |
| Camici, PG; Harari, OA; Kaski, JC; Mason, JC; Recio-Mayoral, A; Rubens, MB | 1 |
| Dervieux, T; Guchelaar, HJ; Kremer, JM; Moore, JH; Penrod, N; van der Straaten, T; Wessels, JA | 1 |
| Gabay, C; Nendaz, M; Schaller, D | 1 |
| Dolzan, V; Grabar, PB; Logar, D; Rojko, S | 1 |
| Borea, PA; Govoni, M; Padovan, M; Trotta, F; Varani, K; Vincenzi, F | 1 |
| Csóka, B; Haskó, G | 1 |
| Borea, PA; Govoni, M; Padovan, M; Targa, M; Trotta, F; Varani, K; Vincenzi, F | 1 |
| Chiocchia, G; Tourneur, L; Vilmont, V | 1 |
| Aránzazu, M; Cronstein, BN; Feig, JL; Mediero, A; Perez-Aso, M | 1 |
| Avenoso, A; Calatroni, A; Campo, GM; Campo, S; D'Ascola, A; Micali, A; Nastasi, G; Pisani, A; Prestipino, V; Puzzolo, D; Scuruchi, M | 1 |
| Borea, PA; Corciulo, C; Gessi, S; Giacuzzo, S; Govoni, M; Merighi, S; Padovan, M; Targa, M; Varani, K; Vincenzi, F | 1 |
| Arduino, N; Bertolotto, M; Cutolo, M; Dallegri, F; Frumento, G; Mancini, M; Ottonello, L; Sottofattori, E | 2 |
| Hatachi, S; Koshiba, M; Kumagai, S; Kurosaka, M; Kusaka, H; Nakamachi, Y; Nakazawa, T; Saura, R | 1 |
| KIVEL, F | 1 |
| ALBERTY, RA; BOCK, RM | 1 |
| Alarcón, GS; Baggott, JE; Lee, JY; Morgan, SL; Oster, RA | 1 |
| Barrera, P; Riksen, NP; Rongen, GA; Smits, P; van den Broek, PH; van Riel, PL | 1 |
| Cronstein, BN | 3 |
| Allaart, CF; Collee, G; De Jonge, R; De Sonnaville, P; De Vries-Bouwstra, JK; Guchelaar, HJ; Huizinga, TW; Kooloos, WM; Lindemans, J; Linssen, A; Wessels, JA | 1 |
| Darlington, LG; Forrest, CM; Harman, G; Mackay, GM; Oxford, L; Stone, TW; Stoy, N | 2 |
| Bar-Yehuda, S; Barer, F; Cohen, S; Fishman, P; Madi, L; Ochayin, A | 1 |
| Borschukova, O; Holoshitz, J; Li, Z; Ling, S; Pumpens, P; Xiao, L | 1 |
| Bar-Yehuda, S; Cohen, S; Fishman, P; Kerns, WD; Ochaion, A; Silverman, MH | 1 |
| Cronstein, BN; Tian, H | 1 |
| Guchelaar, HJ; Huizinga, TW; Wessels, JA | 1 |
| Adawi, M; Caspi, D; Cohen, S; Cohn, I; Farbstein, M; Fishman, P; Fishman-Furman, S; Friedman, J; Green, L; Kerns, WD; Langevitz, P; Mader, R; Markovits, D; Molad, Y; Nahir, M; Ochaion, A; Reitblat, T; Rosner, I; Rozenbaum, M; Rubinow, A; Silverman, MH; Strand, V; Tanay, A; Tishler, M; Yehuda, SB | 1 |
| Bazzichi, L; Bondi, F; Ciompi, ML; Fiorini, M; Lucacchini, A; Martini, C; Tacchi, P | 1 |
| Furst, DE | 1 |
| Cronstein, BN; Merrill, JT | 1 |
| Coffey, D; Cronstein, BN; Fisher, R; Lahita, RG; Merrill, JT; Salmon, J; Schreibman, D; Shen, C; Zakharenko, O | 1 |
| Cedoz, JP; Letroublon, MC; Niveleau, A; Reynaud, C; Tebib, JG | 1 |
| Ferraro, C; Fournel, S; Genestier, L; Miossec, P; Paillot, R; Revillard, JP | 1 |
| Seitz, M | 1 |
| Kremer, JM | 1 |
| Kaznowska, Z; Simmonds, HA; Smoleńska, Z; Smoleński, RT; Zarówny, D | 1 |
| Choi, I; Hong, JH; Hur, GM; Kang, HS; Lee, JH; Lee, JK; Lim, SD; Seok, JH; Sung, JY | 1 |
| Anzaldi, M; Ottonello, L; Sottofattori, E | 1 |
| Cutolo, M; Pizzorni, C; Seriolo, B; Straub, RH; Sulli, A | 1 |
| Brown, MA; Milicic, A; Wordsworth, BP | 1 |
| Hayashi, N; Kitamura, N; Kosaka, H; Koshiba, M; Kumagai, S; Nakazawa, T; Saura, R | 1 |
| Chan, ES; Cronstein, BN | 1 |
| Bazzichi, L; Ciompi, ML; Giannaccini, G; Lucacchini, A; Martini, C; Soletti, A | 1 |
| Agnello, V; Koffler, D; Kunkel, HG; Winchester, R | 1 |
21 review(s) available for adenosine and Rheumatoid Arthritis
| Article | Year |
|---|---|
Topics: Adenosine; Animals; Arthritis, Rheumatoid; Autoimmunity; Humans; Immune System; Joints; Methyltransferases; RNA Processing, Post-Transcriptional; RNA Splicing; RNA Splicing Factors; RNA Stability | 2021 |
ATP and adenosine: Role in the immunopathogenesis of rheumatoid arthritis.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Triphosphate; Animals; Apyrase; Arthritis, Rheumatoid; Biomarkers; GPI-Linked Proteins; Humans; Receptors, Purinergic P2X7; Signal Transduction | 2019 |
Methotrexate pharmacogenetics in the treatment of rheumatoid arthritis.
Topics: Adenosine; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Folic Acid; Humans; Methotrexate; Middle Aged; Pharmacogenetics; Polymorphism, Genetic | 2019 |
Methotrexate an Old Drug with New Tricks.
Topics: Adenosine; Alarmins; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis; Arthritis, Rheumatoid; Cytokines; Folic Acid; HMGB1 Protein; Humans; Immunity, Innate; Inflammation; Matrix Metalloproteinases; Methotrexate; NF-kappa B; Polyamines; Prostaglandins; Reactive Oxygen Species | 2019 |
Perspective and Potential of A2A and A3 Adenosine Receptors as Therapeutic Targets for the Treatment of Rheumatoid Arthritis.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Antagonists; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Receptor, Adenosine A2A; Receptor, Adenosine A3; Signal Transduction | 2019 |
Role and Function of Adenosine and its Receptors in Inflammation, Neuroinflammation, IBS, Autoimmune Inflammatory Disorders, Rheumatoid Arthritis and Psoriasis.
Topics: Adenosine; Arthritis, Rheumatoid; Autoimmune Diseases; Humans; Inflammation; Irritable Bowel Syndrome; Psoriasis; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1 | 2019 |
[Adenosine, its analogues and conjugates].
Topics: Adenosine; Anti-Arrhythmia Agents; Arthritis, Rheumatoid; Half-Life; Humans; Nephritis; Shock, Septic; Tachycardia, Supraventricular; Uveitis | 2013 |
Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers.
Topics: Adenosine; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Cell Adhesion Molecules; Cytokines; Eicosanoids; Folic Acid Antagonists; Humans; Metalloproteases; Methotrexate; Methylation; Pharmacogenomic Variants; Polymorphism, Single Nucleotide; Reactive Oxygen Species; Signal Transduction; Treatment Outcome | 2016 |
[Rheumatoid arthritis, methothrexate, and pulmonary fibrosis: which evidences?].
Topics: Adenosine; Animals; Arthritis, Rheumatoid; Humans; Liver Cirrhosis; Methotrexate; Pulmonary Fibrosis; Smoking | 2010 |
The role of adenosine receptors in rheumatoid arthritis.
Topics: Adenosine; Animals; Arthritis, Rheumatoid; Humans; Inflammation; Purinergic Agonists; Receptors, Purinergic P1 | 2010 |
Fas-associated death domain protein and adenosine partnership: fad in RA.
Topics: Adenosine; Arthritis, Rheumatoid; Fas-Associated Death Domain Protein; Humans; Signal Transduction | 2012 |
The anti-inflammatory effect of A3 adenosine receptor agonists: a novel targeted therapy for rheumatoid arthritis.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Leukocytes, Mononuclear; Membrane Proteins | 2007 |
Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis.
Topics: Adenosine; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Interactions; Humans; Methotrexate; Pharmacogenetics | 2007 |
Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis.
Topics: Adenosine; Animals; Apoptosis; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Proliferation; Clinical Trials as Topic; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Folic Acid; Humans; Immunity, Cellular; Immunosuppression Therapy; Male; Methotrexate; Reactive Oxygen Species; Sensitivity and Specificity; Treatment Outcome | 2008 |
A novel approach to the development of anti-inflammatory agents: adenosine release at inflamed sites.
Topics: Adenosine; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Humans; Inflammation; Methotrexate; Sulfasalazine | 1995 |
Should methotrexate be used to treat early rheumatoid arthritis?
Topics: Adenosine; Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Leukotriene B4; Lymphocytes; Meta-Analysis as Topic; Methotrexate; Neutrophils | 1994 |
The mechanism of action of methotrexate.
Topics: Adenosine; Animals; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Methotrexate; Methylation | 1997 |
Molecular and cellular effects of methotrexate.
Topics: Adenosine; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Cytokines; Humans; Methotrexate; Methylation | 1999 |
Methotrexate and leflunomide: biochemical basis for combination therapy in the treatment of rheumatoid arthritis.
Topics: Adenosine; Arthritis, Rheumatoid; Cell Division; Cytokines; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocytes; Methotrexate; Molecular Structure; Purines; Pyrimidines; Treatment Outcome | 1999 |
Anti-inflammatory mechanisms of methotrexate in rheumatoid arthritis.
Topics: Adenosine; Animals; Antirheumatic Agents; Apoptosis; Arthritis, Rheumatoid; Cell Cycle; Cyclic AMP; Cyclooxygenase Inhibitors; Cytokines; fas Receptor; Humans; Metalloendopeptidases; Methotrexate; Rats | 2001 |
Molecular action of methotrexate in inflammatory diseases.
Topics: Adenosine; Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Methotrexate; Receptors, Purinergic P1 | 2002 |
6 trial(s) available for adenosine and Rheumatoid Arthritis
| Article | Year |
|---|---|
The effect of folic acid and folinic acid supplements on purine metabolism in methotrexate-treated rheumatoid arthritis.
Topics: Adenosine; Aminoimidazole Carboxamide; Arthritis, Rheumatoid; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Purines; Pyridoxine; Ribonucleotides; Treatment Outcome; Vitamin B 12 | 2004 |
Relationship between genetic variants in the adenosine pathway and outcome of methotrexate treatment in patients with recent-onset rheumatoid arthritis.
Topics: Adenosine; Adult; Aged; AMP Deaminase; Antirheumatic Agents; Arthritis, Rheumatoid; DNA; Female; Gene Expression Regulation, Enzymologic; Genetic Variation; Humans; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Single-Blind Method | 2006 |
Adenosine and cytokine levels following treatment of rheumatoid arthritis with dipyridamole.
Topics: Adenosine; Adolescent; Adult; Aged; Arthritis, Rheumatoid; Cytokines; Dipyridamole; Dose-Response Relationship, Drug; Humans; Interleukin-1beta; Interleukin-6; Lipid Peroxidation; Middle Aged; Neopterin; Platelet Aggregation Inhibitors; Treatment Outcome; Tumor Necrosis Factor-alpha; Young Adult | 2006 |
Purine metabolism and clinical status of patients with rheumatoid arthritis treated with dipyridamole.
Topics: Adenosine; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Chromatography, High Pressure Liquid; Cytokines; Dipyridamole; Humans; Middle Aged; Placebos; Purines; Surveys and Questionnaires; Vasodilator Agents | 2006 |
Clinical evidence for utilization of the A3 adenosine receptor as a target to treat rheumatoid arthritis: data from a phase II clinical trial.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Adult; Aged; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Receptor, Adenosine A3; Severity of Illness Index; Treatment Outcome | 2008 |
Effect of methotrexate on blood purine and pyrimidine levels in patients with rheumatoid arthritis.
Topics: Adenosine; Adenosine Triphosphate; Adult; Aminoimidazole Carboxamide; Antirheumatic Agents; Arthritis, Rheumatoid; Chromatography, High Pressure Liquid; Chronic Disease; Cytidine Triphosphate; Erythrocytes; Female; Guanosine Triphosphate; Humans; Hypoxanthine; Methotrexate; Middle Aged; Ribonucleotides; Uric Acid; Uridine | 1999 |
41 other study(ies) available for adenosine and Rheumatoid Arthritis
| Article | Year |
|---|---|
N6-methyladenosine modification of TGM2 mRNA contributes to the inhibitory activity of sarsasapogenin in rheumatoid arthritis fibroblast-like synoviocytes.
Topics: Adenosine; Arthritis, Rheumatoid; Cell Proliferation; Cells, Cultured; Fibroblasts; Humans; RNA, Messenger; Spirostans; Synovial Membrane; Synoviocytes | 2022 |
Identification of Synovial Fibroblast-Associated Neuropeptide Genes and m6A Factors in Rheumatoid Arthritis Using Single-Cell Analysis and Machine Learning.
Topics: Adenosine; Arthritis, Rheumatoid; Fibroblasts; Humans; Machine Learning; Neuropeptides; Single-Cell Analysis; Synovial Membrane | 2022 |
Predictive value of drug efficacy by M6A modification patterns in rheumatoid arthritis patients.
Topics: Adenosine; Arthritis, Rheumatoid; Humans; Infliximab; RNA; RNA-Seq | 2022 |
Comprehensive Analysis and Functional Characteristics of Differential Expression of N6-Methyladenosine Methylation Modification in the Whole Transcriptome of Rheumatoid Arthritis.
Topics: Adenosine; Animals; Arthritis, Rheumatoid; Inflammation; Methylation; Phosphatidylinositol 3-Kinases; RNA, Messenger; Transcriptome | 2022 |
Diagnostic gene signatures and aberrant pathway activation based on m6A methylation regulators in rheumatoid arthritis.
Topics: Adenosine; Arthritis, Rheumatoid; Autoimmune Diseases; Consensus; Humans; Methylation | 2022 |
Increased adenosine-to-inosine RNA editing in rheumatoid arthritis.
Topics: Adenosine; Adenosine Deaminase; Arthritis, Rheumatoid; Female; Gene Expression Regulation; Humans; Inosine; Leukocytes, Mononuclear; Male; Middle Aged; Protein Isoforms; RNA; RNA Editing; RNA-Binding Proteins; Transcriptome; Up-Regulation | 2020 |
Therapeutic Potentials of Adenosine Receptors: The State of The Art.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Arthritis, Rheumatoid; Central Nervous System Diseases; Humans; Neoplasms; Receptor, Adenosine A1; Receptor, Adenosine A2A; Signal Transduction | 2019 |
B cells from Patients with Rheumatoid Arthritis Show Conserved CD39-Mediated Regulatory Function and increased CD39 Expression After Positive Response to Therapy.
Topics: Adenosine; Apyrase; Arthritis, Rheumatoid; B-Lymphocytes; B-Lymphocytes, Regulatory; Case-Control Studies; Cytokines; Disease Management; Disease Susceptibility; Gene Expression; Humans; Immunomodulation; Lymphocyte Activation; Lymphocyte Count; T-Lymphocytes; Treatment Outcome | 2021 |
Role and Function of A
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Arthritis, Psoriatic; Arthritis, Rheumatoid; Case-Control Studies; Cytokines; Female; Humans; Kinetics; Lymphocytes; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Middle Aged; NF-kappa B; Phenethylamines; Pyrazoles; Pyrimidines; Receptor, Adenosine A2A; Receptor, Adenosine A3; RNA, Messenger; Spondylitis, Ankylosing | 2017 |
Extracellular Purine Metabolism Is the Switchboard of Immunosuppressive Macrophages and a Novel Target to Treat Diseases With Macrophage Imbalances.
Topics: Adenosine; Animals; Arthritis, Rheumatoid; Cell Differentiation; Cell Proliferation; Disease Models, Animal; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunosuppressive Agents; Inflammation; Macrophage Colony-Stimulating Factor; Macrophages; Male; Methotrexate; Mice; Monocytes; Purines; Synovial Fluid | 2018 |
Human gingival tissue-derived MSC suppress osteoclastogenesis and bone erosion via CD39-adenosine signal pathway in autoimmune arthritis.
Topics: Adenosine; Animals; Antigens, CD; Apyrase; Arthritis, Experimental; Arthritis, Rheumatoid; Autoimmune Diseases; Biomarkers; Cell Line; Female; Fibroblasts; Gingiva; Humans; Mesenchymal Stem Cells; Mice; Osteoclasts; Osteogenesis; Signal Transduction; Tomography, X-Ray Computed | 2019 |
Low expression of CD39 on regulatory T cells as a biomarker for resistance to methotrexate therapy in rheumatoid arthritis.
Topics: 5'-Nucleotidase; Adenosine; Animals; Antigens, CD; Apyrase; Arthritis, Experimental; Arthritis, Rheumatoid; Biomarkers; Drug Resistance; Humans; Lymphocyte Count; Methotrexate; Mice, Inbred C57BL; T-Lymphocytes, Regulatory; Th1 Cells; Th17 Cells | 2015 |
The A3 adenosine receptor agonist CF502 inhibits the PI3K, PKB/Akt and NF-kappaB signaling pathway in synoviocytes from rheumatoid arthritis patients and in adjuvant-induced arthritis rats.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Arthritis; Arthritis, Rheumatoid; Disease Models, Animal; Humans; Inflammation; NF-kappa B; Phosphatidylinositol 3-Kinases; Protein Kinases; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Synovial Membrane | 2008 |
Chronic inflammation and coronary microvascular dysfunction in patients without risk factors for coronary artery disease.
Topics: Adenosine; Adult; Arthritis, Rheumatoid; Case-Control Studies; Coronary Artery Disease; Coronary Circulation; Endothelium, Vascular; Female; Fractional Flow Reserve, Myocardial; Humans; Inflammation; Lupus Erythematosus, Systemic; Male; Microcirculation; Positron-Emission Tomography; Prospective Studies; Risk Assessment; Vasodilator Agents | 2009 |
Gene-gene interactions in folate and adenosine biosynthesis pathways affect methotrexate efficacy and tolerability in rheumatoid arthritis.
Topics: Adenosine; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biosynthetic Pathways; Epistasis, Genetic; Female; Folic Acid; Humans; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide | 2009 |
Genetic determinants of methotrexate treatment in rheumatoid arthritis patients: a study of polymorphisms in the adenosine pathway.
Topics: Adenosine; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Polymorphism, Single Nucleotide; Severity of Illness Index; Treatment Outcome | 2010 |
Adenosine, inflammation pathways and therapeutic challenges.
Topics: Adenosine; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Inflammation; Signal Transduction; Spinal Cord Injuries | 2011 |
A2A and A3 adenosine receptor expression in rheumatoid arthritis: upregulation, inverse correlation with disease activity score and suppression of inflammatory cytokine and metalloproteinase release.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Aged; Arthritis, Rheumatoid; Blotting, Western; Cells, Cultured; Cytokines; Female; Gene Expression; Humans; Inflammation Mediators; Linear Models; Lymphocytes; Male; Metalloproteases; Middle Aged; NF-kappa B; Phenethylamines; Radioligand Assay; Receptor, Adenosine A2A; Receptor, Adenosine A3; Reverse Transcriptase Polymerase Chain Reaction; Severity of Illness Index; Signal Transduction; Up-Regulation | 2011 |
Adenosine A2A receptor and TNF-α regulate the circadian machinery of the human monocytic THP-1 cells.
Topics: Adenosine; ARNTL Transcription Factors; Arthritis, Rheumatoid; Cell Line; Circadian Clocks; Circadian Rhythm; CLOCK Proteins; Cryptochromes; Fatigue; Humans; Inflammation; Interleukin-1; Interleukin-10; Methotrexate; Monocytes; Period Circadian Proteins; Phenethylamines; Receptor, Adenosine A2A; RNA, Messenger; Tumor Necrosis Factor-alpha | 2013 |
Combined treatment with hyaluronan inhibitor Pep-1 and a selective adenosine A2 receptor agonist reduces inflammation in experimental arthritis.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cells, Cultured; Cytokines; Gene Expression Regulation; Humans; Hyaluronan Receptors; Hyaluronic Acid; Inflammation Mediators; Joints; Male; Matrix Metalloproteinase 13; Mice; Mice, Inbred DBA; Models, Animal; Nitric Oxide Synthase Type II; Peptides; Proteolysis; Receptor, Adenosine A2B; Toll-Like Receptor 2; Toll-Like Receptor 4 | 2013 |
A(2A) adenosine receptors are differentially modulated by pharmacological treatments in rheumatoid arthritis patients and their stimulation ameliorates adjuvant-induced arthritis in rats.
Topics: Adenosine; Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Models, Animal; Humans; Inflammation; Longitudinal Studies; Lymphocytes; Male; Methotrexate; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Receptors, Purinergic P1; Rituximab; Tumor Necrosis Factor-alpha; Up-Regulation | 2013 |
Delayed neutrophil apoptosis induced by synovial fluid in rheumatoid arthritis: role of cytokines, estrogens, and adenosine.
Topics: Adenosine; Adenosine Deaminase; Antigen-Antibody Complex; Apoptosis; Arthritis, Rheumatoid; Cytokines; Depression, Chemical; Estradiol; Estrogens; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukins; Knee Joint; Neutrophils; Oxidative Stress; Respiratory Burst; Superoxides; Synovial Fluid; Tumor Necrosis Factor-alpha | 2002 |
Synovial fluid from patients with rheumatoid arthritis inhibits neutrophil apoptosis: role of adenosine and proinflammatory cytokines.
Topics: Adenosine; Adult; Apoptosis; Arthritis, Rheumatoid; Cells, Cultured; Culture Media; Cytokines; Female; Flow Cytometry; Fluorescent Antibody Technique; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-15; Interleukin-2; Interleukin-8; Knee Joint; Male; Middle Aged; Neutrophils; Sensitivity and Specificity; Synovial Fluid; Tumor Necrosis Factor-alpha | 2002 |
Specific increase in enzymatic activity of adenosine deaminase 1 in rheumatoid synovial fibroblasts.
Topics: Adenosine; Adenosine Deaminase; Arthritis, Rheumatoid; Cells, Cultured; Fibroblasts; Humans; Isoenzymes; Leukocytes, Mononuclear; Monokines; Neutrophils; Osteoarthritis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Synovial Fluid | 2003 |
[Experiences with the treatment of arthrosis of the knee with phosadene].
Topics: Adenosine; Arthritis; Arthritis, Rheumatoid; Disease; Humans; Knee; Knee Joint; Osteoarthritis | 1956 |
Analysis of mixtures of adenosinephosphates by the moving boundary method.
Topics: Adenosine; Arthritis; Arthritis, Rheumatoid; Humans; Phosphates | 1951 |
Methotrexate modulates the kinetics of adenosine in humans in vivo.
Topics: Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dipyridamole; Dose-Response Relationship, Drug; Drug Synergism; Female; Forearm; Hemodynamics; Humans; Male; Methotrexate; Middle Aged; Regional Blood Flow; Severity of Illness Index; Vasodilation; Vasodilator Agents | 2006 |
Going with the flow: methotrexate, adenosine, and blood flow.
Topics: Adenosine; Antirheumatic Agents; Arthritis, Rheumatoid; Forearm; Humans; Methotrexate; Regional Blood Flow | 2006 |
Overexpression of A3 adenosine receptor in peripheral blood mononuclear cells in rheumatoid arthritis: involvement of nuclear factor-kappaB in mediating receptor level.
Topics: Adenosine; Arthritis, Rheumatoid; Gene Expression Regulation; Humans; Interleukin-2; Leukocytes, Mononuclear; Middle Aged; Mitogens; NF-kappa B; Promoter Regions, Genetic; Receptor, Adenosine A3; Tumor Necrosis Factor-alpha | 2007 |
The rheumatoid arthritis shared epitope increases cellular susceptibility to oxidative stress by antagonizing an adenosine-mediated anti-oxidative pathway.
Topics: Adenosine; Antioxidants; Arthritis, Rheumatoid; B-Lymphocytes; Disease Susceptibility; Epitopes, B-Lymphocyte; Humans; Oxidative Stress; Reactive Oxygen Species; Signal Transduction | 2007 |
A2 adenosine receptors in neutrophils from healthy volunteers and patients with rheumatoid arthritis.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Arthritis, Rheumatoid; Binding, Competitive; Cell Membrane; Humans; Kinetics; Neutrophils; Phenethylamines; Radioligand Assay; Receptors, Purinergic P1; Reference Values; Tritium | 1994 |
Mechanisms of the effects of methotrexate.
Topics: Adenosine; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Methylation; Rheumatoid Nodule | 1996 |
Adenosine A1 receptor promotion of multinucleated giant cell formation by human monocytes: a mechanism for methotrexate-induced nodulosis in rheumatoid arthritis.
Topics: Adenosine; Antirheumatic Agents; Arthritis, Rheumatoid; Cells, Cultured; Humans; Methotrexate; Monocytes; Receptors, Purinergic P1; Rheumatoid Nodule; Tetradecanoylphorbol Acetate; Theobromine; Xanthines | 1997 |
Relationship between urinary excretion of modified nucleosides and rheumatoid arthritis process.
Topics: Adenosine; Aged; Arthritis, Rheumatoid; Biomarkers; Cytidine; Female; Follow-Up Studies; Guanosine; Humans; Inosine; Male; Middle Aged; Nucleosides; Pseudouridine; RNA Caps; RNA, Ribosomal; RNA, Transfer | 1997 |
Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells.
Topics: Adenosine; Apoptosis; Arthritis, Rheumatoid; Cell Cycle; Cells, Cultured; Clonal Deletion; Culture Media; Folic Acid Antagonists; Humans; Immunosuppressive Agents; Leukocytes, Mononuclear; Lymphocyte Activation; Methotrexate; Mitogens; Phytohemagglutinins; S Phase; T-Lymphocytes; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 1998 |
Methotrexate suppresses the interleukin-6 induced generation of reactive oxygen species in the synoviocytes of rheumatoid arthritis.
Topics: Adenosine; Arthritis, Rheumatoid; Cell Culture Techniques; Cell Division; Dose-Response Relationship, Drug; Gene Expression; Humans; Inflammation Mediators; Interleukin-1; Interleukin-6; Knee Joint; Methotrexate; Reactive Oxygen Species; RNA, Messenger; Synovial Fluid; Tumor Necrosis Factor-alpha | 2000 |
HPLC determination of adenosine in human synovial fluid.
Topics: Adenosine; Arthritis, Rheumatoid; Calibration; Chromatography, High Pressure Liquid; Humans; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Synovial Fluid | 2001 |
Polymorphism in codon 17 of the CTLA-4 gene (+49 A/G) is not associated with susceptibility to rheumatoid arthritis in British Caucasians.
Topics: Abatacept; Adenosine; Antigens, CD; Antigens, Differentiation; Arthritis, Rheumatoid; Codon; CTLA-4 Antigen; Genetic Predisposition to Disease; Guanosine; Humans; Immunoconjugates; Polymorphism, Genetic; United Kingdom; White People | 2001 |
2-Chloroadenosine but not adenosine induces apoptosis in rheumatoid fibroblasts independently of cell surface adenosine receptor signalling.
Topics: 2-Chloroadenosine; Adenosine; Analgesics; Apoptosis; Arthritis, Rheumatoid; Fibroblasts; HeLa Cells; Humans; Receptors, Cell Surface; Receptors, Purinergic P1; Signal Transduction; Synovial Membrane; Tumor Cells, Cultured | 2002 |
A1 and A2 adenosine receptors in synovial cells from patients with rheumatic diseases.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Arthritis, Rheumatoid; Humans; Receptors, Purinergic; Rheumatic Diseases; Synovial Fluid | 1989 |
The occurrence of single-stranded DNA in the serum of patients with systemic lupus erythematosus and other diseases.
Topics: Adenosine; Animals; Antigen-Antibody Complex; Antigens; Arthritis, Rheumatoid; Cattle; DNA; DNA, Single-Stranded; Glomerulonephritis; Hemagglutination Inhibition Tests; Humans; Immunodiffusion; Leukemia; Lupus Erythematosus, Systemic; Methods; Neoplasms; Rabbits; Serum Albumin; Thymidine | 1973 |