adenosine has been researched along with Parkinson Disease in 71 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (2.82) | 18.7374 |
1990's | 3 (4.23) | 18.2507 |
2000's | 24 (33.80) | 29.6817 |
2010's | 19 (26.76) | 24.3611 |
2020's | 23 (32.39) | 2.80 |
Authors | Studies |
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Ishibashi, K; Ishii, K; Ishiwata, K; Miura, Y; Toyohara, J; Wagatsuma, K | 2 |
Medvedeva, MV; Muronetz, VI; Pozdyshev, DV; Zharikova, AA | 1 |
Catarzi, D; Colotta, V; Francucci, B; Lambertucci, C; Marucci, G; Spinaci, A; Varano, F; Volpini, R | 1 |
Borroto-Escuela, DO; Carlsson, J; Ciruela, F; Crans, RAJ; Fores-Pons, R; Fuxe, K; Lopez-Cano, M; Narváez, M; Romero-Fernandez, W; Taura, JJ | 1 |
Airas, L; Helin, S; Joutsa, J; Parkkola, R; Rinne, JO; Rissanen, E; Tuisku, J; Waggan, I | 1 |
Fathi, M; Hajibeygi, R; Jazi, K; Klegeris, A; McElhinney, A; Sayehmiri, F; Shool, S; Sodeifian, F; Tavasol, A; Tavirani, MR; Vakili, K; Yaghoobpoor, S | 1 |
Cunha, RA; Gonçalves, FQ; Gonçalves, N; Matheus, FC; Oses, JP; Prediger, RD; Real, JI; Rial, D; Rodrigues, RJ; Silva, AC; Silva, HB; Tomé, ÂR | 1 |
Han, YY; Huang, SY; Li, CH; Liu, L; Mai, ZF; Shang, YJ; Su, ZY; Zeng, ZW | 1 |
Gu, L; He, J; Jin, S; Li, R; Peng, Y; Wei, L | 1 |
Kerasidis, A; Nagle, B; Offit, M; Ozay, G; Pagan, F; Torres-Yaghi, Y; Zhang, I | 1 |
Garcia, CP; Licht-Murava, A; Orr, AG | 1 |
Jenner, P; Kanda, T; Mori, A | 1 |
Franco, R; Labandeira-García, JL; Lanciego, JL; Muñoz, A; Navarro, G; Reyes-Resina, I; Rico, AJ; Rivas-Santisteban, R; Rodríguez-Pérez, AI | 1 |
Agnati, LF; Guidolin, D; Marcoli, M; Maura, G; Tortorella, C | 1 |
Chen, JF; Cunha, RA | 1 |
Chen, C; Guo, J; Min, S; Pan, H; Qin, L; Shu, L; Sun, Q; Tang, B; Xu, Q; Yan, X; Zhong, J | 1 |
He, H; Huang, Y; Qiu, X; Wang, J; Xiao, Y | 1 |
Bansal, R; Chauhan, P; Kachler, S; Klotz, KN; Rohilla, S | 1 |
Aradi, SD; Hauser, RA; LeWitt, PA; Rascol, O | 1 |
Chen, JF; Schwarzschild, MA | 1 |
Aradi, SD; Hauser, RA; Jenner, P; Mori, A | 1 |
Ahmed, YR; Aziz, WM; Hamed, MAA; Khalil, WKB; Naser, AFA | 1 |
Amalfitano, J; Jabeen, I; Kadri, H; Lai, YC; Le Duff, CS; Mehellou, Y; Miccoli, A; Muqit, MMK; Osgerby, L; Thornton, PJ; Tucker, JHR | 1 |
Jamwal, S; Kumar, P | 1 |
Fathalla, AM; Moustafa, AA; Soliman, AM | 1 |
Chen, J; Duan, S; Gao, Z; Ge, Q; Guo, F; Guo, Z; Hu, Y; Lou, H; Mai, W; Meng, F; Zhang, B; Zhang, Z | 1 |
Ali, S; Chen, X; Guo, M; Huang, H; Huang, Y; Qie, S; Wang, J; Wang, S; Yu, C; Zhang, L; Zheng, X | 1 |
Borah, P; Deb, PK; Deka, S; Mailavaram, RP | 1 |
Allen, EG; Armstrong, MJ; Jin, P; Jin, Y | 1 |
Müller, T | 2 |
Capuano, B; Jorg, M; Scammells, PJ | 1 |
Borroto-Escuela, DO; Franco, R; Fuxe, K; Navarro, G | 1 |
Boyle, CD; Chackalamannil, S; Cohen-Williams, ME; Greenlee, WJ; Higgins, GA; Lachowicz, JE; Lankin, CM; Neustadt, BR; Ng, K; Shah, U; Varty, GB; Zhang, H | 1 |
Betz, AJ; Correa, M; Farrar, AM; Font, L; Hockemeyer, J; Ishiwari, K; Mingote, SM; Müller, CE; Salamone, JD | 1 |
Chen, JF; Fredholm, BB; Hauser, R; Jenner, P; Morelli, M; Mori, A | 1 |
Chung, EJ; Kim, BJ; Lee, GH; Lee, WY; Yoon, WT | 1 |
Borea, PA; Casetta, I; Fazio, P; Gessi, S; Granieri, E; Granieri, G; Leung, E; MacLennan, S; Tosi, A; Varani, K; Vincenzi, F | 1 |
Carta, AR; Kachroo, A; Morelli, M; Schwarzschild, MA | 1 |
Che, PL; Du, J; Ha, B; Wang, Z; Yarema, KJ | 1 |
Sperlágh, B; Vizi, ES | 1 |
Burnstock, G; Fredholm, BB; Verkhratsky, A | 1 |
Guo, KW; Hsu, LF; Tan, JK | 1 |
Ahmed, I; Bose, SK; Brooks, DJ; Pavese, N; Ramlackhansingh, AF; Turkheimer, FE | 1 |
Alexander, E; Beeler, JA; Bernandez, MS; Bernardez Sarria, MS; Frank, MJ; McDaid, J; McGehee, DS; Turkson, S; Zhuang, X | 1 |
Górska, A; Gołembiowska, K; Kamińska, K; Noworyta-Sokołowska, K; Wardas, J | 1 |
Aceves, J; Barajas, C; Erlij, D; Florán, B; Florán, L | 1 |
Morelli, M | 1 |
Fredholm, BB; Svenningsson, P | 1 |
Mori, A; Shindou, T | 1 |
Chen, JF | 1 |
Agnati, LF; Ferré, S; Franco, R; Fuxe, K; Hockemeyer, J; Leo, G; Lluis, C; Martínez, E; Vergoni, AV | 1 |
Cristalli, G; Morelli, M; Pinna, A; Volpini, R | 1 |
Agnati, L; Antonelli, T; Ferraro, L; Fuxe, K; Mazzoni, E; Tanganelli, S; Tomasini, MC | 1 |
Cacciari, B; Cristalli, G; Dal Ben, D; Lambertucci, C; Moro, S; Spalluto, G; Volpini, R | 1 |
Chern, Y; Franco, R; Fredholm, BB; Sitkovsky, M | 1 |
Boison, D | 1 |
Pamplona, FA; Prediger, RD; Takahashi, RN | 1 |
Asaad, W; Eskandar, E | 1 |
Ramkumar, V; Toth, LA; Xie, X | 1 |
Adami, M; Bertorelli, R; Ferri, C; Ongini, E | 1 |
Ikeda, K; Jackson, MJ; Jenner, PG; Kanda, T; Kase, H; Koga, K; Kurokawa, M; Kuwana, Y; Ochi, M; Pearce, RK; Shiozaki, S; Smith, LA | 1 |
Camp, DM; Harel, E; Juneau, PL; LeWitt, PA; Loeffler, DA | 1 |
Ferré, S; Fuxe, K; Müller, CE; Popoli, P; Strömberg, I | 1 |
Silkis, I | 1 |
Sil'kis, IG | 1 |
Kase, H | 1 |
Martinez-Mir, MI; Palacios, JM; Probst, A | 1 |
Ceccato, S; Passeri, M | 1 |
Lipinski, J; Matthysse, S; Shih, V | 1 |
32 review(s) available for adenosine and Parkinson Disease
Article | Year |
---|---|
A
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Humans; Neuroprotective Agents; Parkinson Disease; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A2A | 2022 |
Dynamic changes in metabolites of the kynurenine pathway in Alzheimer's disease, Parkinson's disease, and Huntington's disease: A systematic Review and meta-analysis.
Topics: 3-Hydroxyanthranilic Acid; Adenosine; Alzheimer Disease; Humans; Huntington Disease; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; NAD; Niacinamide; Parkinson Disease; Tryptophan | 2022 |
Effects of adenosine A
Topics: Adenosine; Animals; Brain Injuries; Cognition; Cognitive Dysfunction; Humans; Parkinson Disease | 2023 |
Adenosine A
Topics: Adenosine; Allosteric Site; Animals; Astrocytes; Central Nervous System; Computational Biology; Dopamine; Humans; Mice; Neurons; Parkinson Disease; Protein Binding; Protein Conformation; Protein Multimerization; Receptor, Adenosine A2A; Receptors, Dopamine D2; Schizophrenia; Signal Transduction | 2020 |
The belated US FDA approval of the adenosine A
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Humans; Parkinson Disease; Purines; Receptor, Adenosine A2A; United States; United States Food and Drug Administration | 2020 |
Do caffeine and more selective adenosine A
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Disease Models, Animal; Humans; Neuroprotective Agents; Parkinson Disease; Receptor, Adenosine A2A | 2020 |
Istradefylline - a first generation adenosine A
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Humans; Parkinson Disease; Purines | 2021 |
Insight Into the Emerging Role of Striatal Neurotransmitters in the Pathophysiology of Parkinson's Disease and Huntington's Disease: A Review.
Topics: Acetylcholine; Adenosine; Animals; Basal Ganglia; Cannabinoids; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Huntington Disease; Neuropeptides; Parkinson Disease; Synaptic Transmission | 2019 |
Adenosine role in brain functions: Pathophysiological influence on Parkinson's disease and other brain disorders.
Topics: Adenosine; Brain Diseases; Caffeine; Dopamine; Humans; Parkinson Disease | 2018 |
P1 Receptor Agonists/Antagonists in Clinical Trials - Potential Drug Candidates of the Future.
Topics: Adenosine; Asthma; Cardiovascular Diseases; Clinical Trials as Topic; Humans; Ligands; Neoplasms; Parkinson Disease; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Pyrazoles; Receptors, Purinergic P1 | 2019 |
Diverse and dynamic DNA modifications in brain and diseases.
Topics: Adenosine; Alzheimer Disease; Animals; Ataxia; Brain; Chromatin; Cytosine; DNA; DNA Methylation; Epigenesis, Genetic; Histones; Humans; Mice; Neurodegenerative Diseases; Parkinson Disease | 2019 |
Suitability of the adenosine antagonist istradefylline for the treatment of Parkinson's disease: pharmacokinetic and clinical considerations.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Blood-Brain Barrier; Disease Models, Animal; Dopamine Agonists; Dyskinesias; Half-Life; Humans; Levodopa; Parkinson Disease; Purines; Treatment Outcome | 2013 |
The dopamine D2 and adenosine A2A receptors: past, present and future trends for the treatment of Parkinson's disease.
Topics: Adenosine; Animals; Dopamine; Drug Discovery; History, 19th Century; History, 20th Century; History, 21st Century; Humans; Parkinson Disease; Receptor, Adenosine A2A; Receptors, Dopamine D2 | 2014 |
Purinergic signaling in Parkinson's disease. Relevance for treatment.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Basal Ganglia; Corpus Striatum; Humans; Parkinson Disease; Purine Nucleotides; Purines; Pyrimidines; Receptor, Adenosine A2A; Receptors, Dopamine D2; Signal Transduction; Triazoles | 2016 |
Dopamine/adenosine interactions related to locomotion and tremor in animal models: possible relevance to parkinsonism.
Topics: Adenosine; Animals; Disease Models, Animal; Dopamine; Humans; Locomotion; Parkinson Disease; Tremor | 2008 |
Adenosine, adenosine A 2A antagonists, and Parkinson's disease.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Basal Ganglia; Clinical Trials as Topic; Humans; Parkinson Disease; Purines; Receptors, Purinergic P1 | 2009 |
Pathophysiological roles for purines: adenosine, caffeine and urate.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Caffeine; Dopamine; Humans; Neuroprotective Agents; Parkinson Disease; Purines; Receptor, Adenosine A2A; Uric Acid | 2010 |
The role of extracellular adenosine in chemical neurotransmission in the hippocampus and Basal Ganglia: pharmacological and clinical aspects.
Topics: Adenosine; Adenosine Triphosphate; Animals; Basal Ganglia; Extracellular Space; Gene Expression; Hippocampus; Humans; Ischemia; Mice; Nerve Net; Neuroglia; Neurons; Neurotransmitter Agents; Parkinson Disease; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Receptors, Purinergic P1; Synaptic Transmission | 2011 |
Adenosine and ATP receptors in the brain.
Topics: Adenosine; Adenosine Triphosphate; Animals; Brain; Dogs; Epilepsy; Female; Gene Expression; Humans; Ischemia; Mice; Neuralgia; Neuroglia; Neurons; Neurotransmitter Agents; Parkinson Disease; Rabbits; Rats; Receptors, Purinergic P1; Receptors, Purinergic P2; Synaptic Transmission | 2011 |
Adenosine A2A antagonists: potential preventive and palliative treatment for Parkinson's disease.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Caffeine; Central Nervous System Stimulants; Humans; Neuroprotective Agents; Palliative Care; Parkinson Disease; Parkinson Disease, Secondary; Rats | 2003 |
Adenosine-dopamine interactions: development of a concept and some comments on therapeutic possibilities.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Corpus Striatum; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Humans; Mice; Nerve Tissue Proteins; Parkinson Disease; Phosphoproteins; Phosphorylation; Pyrimidines; Receptor, Adenosine A2A; Receptors, Dopamine D2; Signal Transduction; Triazoles | 2003 |
The adenosine A(2A) receptor as an attractive target for Parkinson's disease treatment.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Brain; Caffeine; Dopamine; Humans; Levodopa; Neuroprotective Agents; Parkinson Disease; Receptor, Adenosine A2A; Treatment Failure | 2003 |
Aspects of the general biology of adenosine A2A signaling.
Topics: Adenosine; Animals; Dimerization; Encephalitis; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia, Brain; Parkinson Disease; Receptor, Adenosine A2A; Receptors, G-Protein-Coupled; Signal Transduction | 2007 |
Adenosine as a neuromodulator in neurological diseases.
Topics: Adenosine; Adenosine Kinase; Alzheimer Disease; Animals; Brain Diseases; Brain Ischemia; Epilepsy; Humans; Huntington Disease; Pain; Parkinson Disease; Schizophrenia; Synaptic Transmission | 2008 |
Adenosine receptor antagonists for cognitive dysfunction: a review of animal studies.
Topics: Adenosine; Alzheimer Disease; Animals; Attention Deficit Disorder with Hyperactivity; Cognition Disorders; Disease Models, Animal; Humans; Learning; Memory; Parkinson Disease; Purinergic P1 Receptor Antagonists; Rats; Rats, Inbred SHR; Receptors, Purinergic P1 | 2008 |
Adenosine and dopamine receptor interactions in striatum and caffeine-induced behavioral activation.
Topics: Adenosine; Animals; Behavior, Animal; Caffeine; Corpus Striatum; Dopamine; Humans; Locomotion; Models, Biological; Parkinson Disease; Parkinsonian Disorders; Receptors, Dopamine; Receptors, Purinergic P1; Rodentia; Signal Transduction | 2007 |
Adenosine A2A receptors and neuroprotection.
Topics: Adenosine; Animals; Brain; Brain Diseases; Brain Ischemia; Dopamine; Humans; Neuroprotective Agents; Parkinson Disease; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A2A; Receptors, Purinergic P1; Seizures | 1997 |
Antiparkinsonian activity of adenosine A2A antagonists in experimental models.
Topics: Adenosine; Antiparkinson Agents; Humans; Motor Activity; Parkinson Disease; Phenethylamines; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Xanthines | 1999 |
The cortico-basal ganglia-thalamocortical circuit with synaptic plasticity. II. Mechanism of synergistic modulation of thalamic activity via the direct and indirect pathways through the basal ganglia.
Topics: Adenosine; Basal Ganglia; Cerebral Cortex; Dopamine; Humans; Huntington Disease; Long-Term Potentiation; Models, Neurological; Movement Disorders; Neural Pathways; Parkinson Disease; Signal Transduction; Synapses; Thalamus | 2001 |
[Mechanisms of effects of adenosine and dopamine on modification of synapses in striato-nigral and striato-pallidal neurons].
Topics: Adenosine; Animals; Dopamine; Dopamine Agonists; Dopamine Antagonists; Globus Pallidus; Huntington Disease; Motor Activity; Parkinson Disease; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A2A; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Purinergic P1; Substantia Nigra; Synapses; Synaptic Transmission | 2001 |
Non-dopaminergic drug treatment of Parkinson's disease.
Topics: Adenosine; Adrenergic alpha-Antagonists; Body Weight; Cholinergic Antagonists; Homocysteine; Humans; Levodopa; Methionine; N-Methylaspartate; Parkinson Disease; Piperidines; Serotonin Receptor Agonists | 2001 |
New aspects of physiological and pathophysiological functions of adenosine A2A receptor in basal ganglia.
Topics: Adenosine; Animals; Basal Ganglia; gamma-Aminobutyric Acid; Humans; Models, Neurological; Neurotransmitter Agents; Parkinson Disease; Parkinsonian Disorders; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A2A; Receptors, Purinergic P1; Synaptic Transmission | 2001 |
1 trial(s) available for adenosine and Parkinson Disease
Article | Year |
---|---|
MIBG scintigraphy for differentiating Parkinson's disease with autonomic dysfunction from Parkinsonism-predominant multiple system atrophy.
Topics: 3-Iodobenzylguanidine; Adenosine; Aged; Autonomic Nervous System Diseases; Diagnosis, Differential; Female; Galvanic Skin Response; Heart; Heart Rate; Humans; Iodine Radioisotopes; Male; Middle Aged; Multiple System Atrophy; Parkinson Disease; Parkinsonian Disorders; Predictive Value of Tests; Prospective Studies; Radiopharmaceuticals; Respiration; Sensitivity and Specificity; Sympathetic Fibers, Postganglionic; Tomography, Emission-Computed, Single-Photon; Valsalva Maneuver | 2009 |
38 other study(ies) available for adenosine and Parkinson Disease
Article | Year |
---|---|
Adenosine A
Topics: Adenosine; Caffeine; Coffee; Humans; Parkinson Disease; Receptor, Adenosine A2A | 2022 |
Differential Analysis of A-to-I mRNA Edited Sites in Parkinson's Disease.
Topics: Adenosine; Aged; Humans; Inosine; Male; Mitochondria; Parkinson Disease; Prefrontal Cortex; Proteome; RNA; RNA Editing; RNA, Messenger; Sequence Analysis, RNA; Transcriptome | 2021 |
The mGlu
Topics: Adenosine; Animals; Catalepsy; Dopamine; Haloperidol; HEK293 Cells; Humans; Mice; Parkinson Disease; Protein Subunits; Rats; Receptor, Adenosine A2A; Receptors, Dopamine D2 | 2022 |
Adenosine A
Topics: Adenosine; Dyskinesias; Humans; Levodopa; Parkinson Disease; Receptor, Adenosine A2A | 2023 |
Increased ATP Release and Higher Impact of Adenosine A
Topics: Adenosine; Adenosine Triphosphate; Animals; Humans; Long-Term Potentiation; Mice; Neuronal Plasticity; Parkinson Disease; Rats | 2023 |
Cordycepin improved the cognitive function through regulating adenosine A
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adenosine; Animals; Cognition; Disease Models, Animal; Mice; Mice, Inbred C57BL; Parkinson Disease | 2023 |
Exercise attenuates neuronal degeneration in Parkinson's disease rat model by regulating the level of adenosine 2A receptor.
Topics: Adenosine; Animals; Cytokines; Parkinson Disease; Phenethylamines; Rats | 2023 |
Adenosine A
Topics: Acetylcholine; Adenosine; Dopamine; Dopamine Agonists; Humans; Parkinson Disease | 2023 |
How and why the adenosine A
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Basal Ganglia; Brain; Dopamine; Humans; Parkinson Disease; Receptor, Adenosine A2A | 2023 |
Boolean analysis shows a high proportion of dopamine D
Topics: Adenosine; Animals; Corpus Striatum; Dopamine; Medium Spiny Neurons; Parkinson Disease; Primates; Rats; Receptor, Adenosine A2A; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Purinergic P1; Reproducibility of Results | 2023 |
Genetic analysis of N6-methyladenosine modification genes in Parkinson's disease.
Topics: Adenosine; Aged; Aged, 80 and over; Asian People; Brain; Cell Cycle Proteins; Female; Genetic Association Studies; Genetic Variation; Humans; Male; Methyltransferases; Middle Aged; Parkinson Disease; Risk; RNA Processing, Post-Transcriptional; RNA Splicing Factors | 2020 |
Genome-wide identification of m
Topics: Adenosine; AlkB Homolog 5, RNA Demethylase; Databases, Genetic; Gene Expression; Gene Expression Regulation; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Intracellular Signaling Peptides and Proteins; Parkinson Disease; Polymorphism, Single Nucleotide; Protein Serine-Threonine Kinases; Quantitative Trait Loci | 2020 |
A New Series of 1,3-Dimethylxanthine Based Adenosine A
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Molecular Docking Simulation; Parkinson Disease; Rats; Receptor, Adenosine A2A; Structure-Activity Relationship; Theophylline | 2021 |
Adenosine A
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Antiparkinson Agents; Humans; Parkinson Disease; Purines; Receptor, Adenosine A2A | 2021 |
The challenge of developing adenosine A
Topics: Adenosine; Animals; Antiparkinson Agents; Benzothiazoles; Humans; Levodopa; Parkinson Disease; Purines | 2020 |
Parkinsonism-like Disease Induced by Rotenone in Rats: Treatment Role of Curcumin, Dopamine Agonist and Adenosine A
Topics: Adenosine; Aged; Animals; Curcumin; Disease Models, Animal; Dopamine Agonists; Humans; Inflammation Mediators; Mice; Neuroprotective Agents; Parkinson Disease; Parkinsonian Disorders; Rats; Receptor, Adenosine A2A; Rotenone | 2022 |
Kinetin Riboside and Its ProTides Activate the Parkinson's Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent of Mitochondrial Depolarization.
Topics: Adenosine; Animals; Carbon-13 Magnetic Resonance Spectroscopy; Humans; Kinetin; Mitochondria; Parkinson Disease; Protein Kinases; Proton Magnetic Resonance Spectroscopy; Spectrometry, Mass, Electrospray Ionization | 2017 |
CD73-derived adenosine controls inflammation and neurodegeneration by modulating dopamine signalling.
Topics: 5'-Nucleotidase; Adenosine; Animals; Disease Models, Animal; Dopamine; Dopaminergic Neurons; GPI-Linked Proteins; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Neurodegenerative Diseases; Parkinson Disease; Receptor, Adenosine A2A; Signal Transduction | 2019 |
Down-Regulation of m6A mRNA Methylation Is Involved in Dopaminergic Neuronal Death.
Topics: Adenosine; Animals; Apoptosis; Brain; Cell Death; Disease Models, Animal; Dopaminergic Neurons; Down-Regulation; Epigenesis, Genetic; Male; Methylation; Oxidopamine; Parkinson Disease; PC12 Cells; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sympatholytics | 2019 |
Design, synthesis, and evaluation of fused heterocyclic analogs of SCH 58261 as adenosine A2A receptor antagonists.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Administration, Oral; Animals; Area Under Curve; Chemistry, Pharmaceutical; Disease Models, Animal; Drug Design; Hydrogen-Ion Concentration; Models, Chemical; Parkinson Disease; Pyrimidines; Rats; Solubility; Triazoles; Water | 2008 |
A2A adenosine receptor overexpression and functionality, as well as TNF-alpha levels, correlate with motor symptoms in Parkinson's disease.
Topics: Adenosine; Aged; Aged, 80 and over; Animals; Autopsy; Cyclic AMP; Dopamine; Female; Humans; Lymphocytes; Male; Middle Aged; Neutrophils; Parkinson Disease; PC12 Cells; Putamen; Rats; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptor, Adenosine A3; Receptors, Dopamine D2; RNA, Messenger; Tumor Necrosis Factor-alpha | 2010 |
Static magnetic field exposure reproduces cellular effects of the Parkinson's disease drug candidate ZM241385.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine Triphosphate; Analysis of Variance; Animals; Blotting, Western; Calcium; Cell Proliferation; Cyclic AMP; Iron; Magnetic Field Therapy; Magnetics; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurites; Parkinson Disease; PC12 Cells; Phenethylamines; Phosphorylation; Rats; Receptor, Adenosine A2A; Triazines; Triazoles | 2010 |
Palpitations and narrow-complex tachycardia.
Topics: Adenosine; Diagnosis, Differential; Dyspnea; Electric Countershock; Electrocardiography; Humans; Hypertension; Male; Middle Aged; Parkinson Disease; Tachycardia; Treatment Outcome | 2011 |
Adenosine 2A receptor availability in dyskinetic and nondyskinetic patients with Parkinson disease.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Aged; Animals; Antiparkinson Agents; Corpus Striatum; Dyskinesia, Drug-Induced; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Positron-Emission Tomography; Pyrazoles; Pyrimidines; Receptor, Adenosine A2A | 2011 |
A role for dopamine-mediated learning in the pathophysiology and treatment of Parkinson's disease.
Topics: Adenosine; Animals; Behavior, Animal; Dopamine; Dopamine D2 Receptor Antagonists; Learning; Mice; Mice, Transgenic; Motor Activity; Parkinson Disease; Receptors, Dopamine D2; Signal Transduction | 2012 |
Effects of adenosine receptor antagonists on the in vivo LPS-induced inflammation model of Parkinson's disease.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Corpus Striatum; Dopamine; Dopaminergic Neurons; Glutamic Acid; Hydroxyl Radical; Inflammation; Lipopolysaccharides; Male; Microinjections; Parkinson Disease; Purines; Rats; Receptor, Adenosine A2A | 2013 |
Adenosine A1 receptors control dopamine D1-dependent [(3)H]GABA release in slices of substantia nigra pars reticulata and motor behavior in the rat.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Animals; Calcium Signaling; Dopamine Agonists; Dopamine Antagonists; gamma-Aminobutyric Acid; Male; Motor Activity; Neural Inhibition; Neurons; Organ Culture Techniques; Parkinson Disease; Potassium; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Purinergic P1; Substantia Nigra; Synaptic Transmission; Tritium; Xanthines | 2002 |
Modulation of GABAergic transmission in the striatopallidal system by adenosine A2A receptors: a potential mechanism for the antiparkinsonian effects of A2A antagonists.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Corpus Striatum; gamma-Aminobutyric Acid; Globus Pallidus; In Vitro Techniques; Neurons; Parkinson Disease; Patch-Clamp Techniques; Phenethylamines; Rats; Receptor, Adenosine A2A; Synaptic Transmission | 2003 |
Neuroprotective effect of L-DOPA co-administered with the adenosine A2A receptor agonist CGS 21680 in an animal model of Parkinson's disease.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Analysis of Variance; Animals; Antiparkinson Agents; Apomorphine; Cell Count; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Drug Therapy, Combination; Dyskinesias; Immunohistochemistry; Levodopa; Male; Oxidopamine; Parkinson Disease; Phenethylamines; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Sympatholytics; Time Factors; Tyrosine 3-Monooxygenase | 2004 |
New adenosine A2A receptor antagonists: actions on Parkinson's disease models.
Topics: Adenine; Adenosine; Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Behavior, Animal; Binding, Competitive; Catalepsy; CHO Cells; Cricetinae; Cricetulus; Disease Models, Animal; Drug Synergism; Levodopa; Male; Molecular Structure; Parkinson Disease; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Tritium | 2005 |
Experimental studies and theoretical aspects on A2A/D2 receptor interactions in a model of Parkinson's disease. Relevance for L-dopa induced dyskinesias.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Adrenergic Agents; Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Interactions; Electrochemistry; gamma-Aminobutyric Acid; Globus Pallidus; Male; Microdialysis; Models, Biological; Oxidopamine; Parkinson Disease; Phenethylamines; Quinpirole; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Dopamine D2 | 2006 |
Highlights on the development of A(2A) adenosine receptor agonists and antagonists.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Drug Design; Humans; Parkinson Disease; Receptors, G-Protein-Coupled; Spinal Cord Injuries; Structure-Activity Relationship | 2007 |
The movers and shakers of deep brain stimulation.
Topics: Adenosine; Animals; Cerebellum; Deep Brain Stimulation; Humans; Mice; Models, Biological; Parkinson Disease; Thalamus; Tremor | 2008 |
Purine-induced alterations of dopamine metabolism in rat pheochromocytoma PC12 cells.
Topics: Adenine; Adenosine; Animals; Disease Models, Animal; Dopamine; Guanine; Guanosine; Hypoxanthine; Neostriatum; Neural Pathways; Neurons; Parkinson Disease; PC12 Cells; Purines; Rats; Substantia Nigra; Uric Acid; Xanthine | 2000 |
Electrophysiological and behavioural evidence for an antagonistic modulatory role of adenosine A2A receptors in dopamine D2 receptor regulation in the rat dopamine-denervated striatum.
Topics: Adenosine; Animals; Corpus Striatum; Denervation; Disease Models, Animal; Dopamine; Functional Laterality; Humans; Male; Oxidopamine; Parkinson Disease; Phenethylamines; Purinergic P1 Receptor Antagonists; Quinpirole; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Dopamine D2; Receptors, Purinergic P1; Reference Values | 2000 |
Adenosine A2 receptors: selective localization in the human basal ganglia and alterations with disease.
Topics: Adenosine; Aged; Aged, 80 and over; Animals; Basal Ganglia; Corpus Striatum; Female; Guinea Pigs; Humans; Huntington Disease; Male; Middle Aged; Nerve Degeneration; Organ Specificity; Oxidopamine; Parkinson Disease; Quinolinic Acid; Quinolinic Acids; Receptors, Purinergic | 1991 |
[Significance of transmethylation and S-adenosylmethionine (SAM) in the management of Parkinson's disease with L-dopa].
Topics: Adenosine; Aged; Brain; Digestive System; Dihydroxyphenylalanine; Feeding and Eating Disorders; Female; Gastrointestinal Diseases; Humans; Injections, Intramuscular; Injections, Intravenous; Kidney; Male; Methionine; Methylation; Nausea; Parkinson Disease; S-Adenosylmethionine; Vomiting | 1972 |
L-dopa and S-adenosylmethionine.
Topics: Adenosine; Carbon Isotopes; Dihydroxyphenylalanine; Humans; Methionine; Parkinson Disease; S-Adenosylmethionine; Time Factors; Tritium | 1971 |