adenosine has been researched along with Leukemia L 1210 in 88 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 71 (80.68) | 18.7374 |
1990's | 17 (19.32) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Allan, PW; Bennett, LL; Chang, CH; Montgomery, JA; Rose, LM; Secrist, JA | 1 |
Bordoni, T; Cristalli, G; Franchetti, P; Geroni, C; Grifantini, M; Vittori, S | 1 |
Montgomery, JA; Secrist, JA; Shortnacy, AT | 1 |
Clayton, SJ; Montgomery, JA; Secrist, JA | 1 |
Bussolari, JC; Chen, SF; Panzica, RP; Ramesh, K; Stoeckler, JD | 1 |
Abbasi, MM; Beisler, JA; Glazer, RI; Peale, AL | 1 |
Glazer, RI; Hartman, KD | 2 |
Bennett, LL; Brockman, RW; Cha, S; Chang, CH | 1 |
Arnett, G; Clayton, JD; Shannon, WM; Shealy, YF | 1 |
Ferro, AJ; Riscoe, MK; White, MW | 1 |
Carson, DA; Kamatani, N; Willis, EH | 1 |
Chang, Y; Hacker, B | 3 |
Hacker, MP; Newman, RA | 1 |
Chello, PL; Dorick, DM; Montgomery, JA; Sirotnak, FM | 1 |
Chello, PL; Dorick, DM; Montgomery, JA; Sirotnak, FM; Yang, CH | 1 |
Backlund, PS; Smith, RA | 1 |
Cybulski, RL; Fry, DW; Goldman, ID | 1 |
Cass, CE; Muhs, WH; Robins, MJ; Selner, M; Tan, TH | 1 |
Rabinovitz, M; Uehara, Y | 1 |
Chheda, GB; Dutta, SP; Mittelman, A | 1 |
Glazer, RI; Stern, HJ | 1 |
Fisher, JM; Rabinovitz, M; Uehara, Y | 1 |
Bernacki, RJ; Bullard, GA; Fleysher, MH | 1 |
Andrei, G; Balzarini, J; Chen, X; De Clercq, E; Ikeda, S; Rao, J; Schneller, SW; Siddiqi, SM; Snoeck, R | 1 |
Balzarini, J; Baraldi, PG; Bazzanini, R; De Clercq, E; Manfredini, S; Marangoni, M; Simoni, D | 1 |
Balzarini, J; Bohman, C; De Clercq, E; Fridland, A; Herdewijn, P; Horská, K; Karlsson, A; Van Aerschot, A; Votruba, I; Wang, L | 1 |
Balzarini, J; Borchardt, RT; De Clercq, E; Robins, MJ; Wnuk, SF; Yuan, CS | 2 |
Cory, AH; Cory, JG | 1 |
Andrei, G; Balzarini, J; Chen, X; De Clercq, E; Ikeda, S; Schneller, SW; Siddiqi, SM; Snoeck, R | 1 |
Kessel, D; Zemlicka, J | 1 |
Cass, CE; Ellison, MJ; Hogue, DL; Young, JD | 1 |
Geiger, JD; Mukherjee, K; Parkinson, FE | 1 |
Hakala, MT; Slocum, HK | 1 |
Dethmers, JK; Lemmen, KL; Lemmen, LJ; Mungall, WS; Norling, LL | 1 |
Glazer, RI; Peale, AL | 3 |
Glazer, RI; Legraverend, M | 1 |
Harrap, KR; Smyth, JF | 1 |
Mittelman, A; Nechaev, A; Tritsch, GL | 1 |
Chheda, GB; Cox, C; Dutta, SP; Hong, CI; Parthasarthy, R; Tritsch, GL | 1 |
Harrap, KR; Paine, RM | 1 |
Shavelson, LJ; Tritsch, GL | 1 |
Chheda, GB; Cox, C; Dutta, SP; Tritsch, GL | 1 |
Belt, JA; Cass, CE; Dagnino, L; Gati, WP; Paterson, AR; Vijayalakshmi, D | 1 |
Bennett, LL; Dagnino, L; Paterson, AR | 2 |
Bernacki, RJ; Borchardt, RT; Kramer, DL; Lee, YH; Libby, PR; Miller, JT; Porter, CW; Spiess, AJ; Sufrin, JR | 1 |
Borchardt, RT; Kramer, DL; Porter, CW; Sufrin, JR | 1 |
Cory, JG; Matsumoto, M; Rey, DA | 1 |
Fukukawa, K; Hoshi, A; Iigo, M; Tokuzen, R; Ueda, T; Yoshida, M | 1 |
Fukuyasu, H; Hoshi, A; Kazuno, Y; Nakajima, S; Sato, Y; Yoshida, M | 1 |
Kawakami, T; Komiyama, K; Omura, S; Tanaka, H; Yang, ZB | 1 |
Dagnino, L; Gati, WP; Paterson, AR | 1 |
Coward, JK; Pegg, AE; Poulin, R; Wechter, R; Woster, PM | 1 |
Matsumura, Y; Morizawa, Y; Nakayama, T; Uchida, K; Yasuda, A | 1 |
Arakawa, E; Kato, T; Ogawa, S; Suzumura, Y; Takamura, T | 1 |
Cory, JG; Weckbecker, G | 1 |
Allen, TM; Baer, HP; Cass, CE; Clanachan, AS; Cook, DA; Fathi-Afshar, R; Krueger, CA; Vriend, R | 1 |
Gaetjens, E; Lerner, LM; Sheid, B | 2 |
Davies, LC; Harrap, KR; Orr, RM; Powles, RL; Stock, JA; Taylor, GA | 1 |
Adamson, DJ; Bennett, LL; Rose, LM; Shaddix, SC; Smithers, D; Thomas, HJ | 1 |
Barlowe, CK; Goldman, ID; Matherly, LH; Phillips, VM | 1 |
Allan, PW; Bennett, LL; Brockman, RW; Clayton, JD; Rose, LM; Shaddix, SC; Shealy, YF | 1 |
Madhubala, R; Pegg, AE; Secrist, JA | 2 |
Jones, DB; Pegg, AE; Secrist, JA | 1 |
Allan, PW; Bennett, LL; Comber, RN; Rose, LM; Secrist, JA | 1 |
Phadtare, S; Zemlicka, J | 1 |
Arakawa, E; Kato, T; Ogawa, S; Suzumura, Y | 1 |
Plagemann, PG; Wohlhueter, RM | 1 |
Chu, MY; Chu, SH; Parks, RE; Savarese, TM | 1 |
Inaba, M; Nagashima, K; Sakurai, Y; Tsukagoshi, S | 1 |
Bloomer, LC; Patil, VD; Townsend, LB; Wise, DS; Wotring, LL | 1 |
Montgomery, JA; Shortnacy, AT; Thomas, HJ | 1 |
Fleysher, MH | 1 |
Bloch, A; Broom, AD; Christensen, LF; Robins, MJ | 1 |
Dodd, DC; Kessel, D | 1 |
Divekar, AY; Grindey, GB; Hakala, MT | 1 |
Heby, O; Russell, DH; Sauter, S | 1 |
Bloch, A; Coutsogeorgopoulos, C | 1 |
Mihich, E; Rustum, Y | 1 |
Chao, DL; Kimball, AP | 1 |
88 other study(ies) available for adenosine and Leukemia L 1210
Article | Year |
---|---|
Synthesis and biochemical properties of 8-amino-6-fluoro-9-beta-D-ribofuranosyl-9H-purine.
Topics: Adenosine Deaminase Inhibitors; AMP Deaminase; Animals; Antineoplastic Agents; Cell Line; Cell Survival; Coformycin; Inosine Monophosphate; Kinetics; Leukemia L1210; Pentostatin; Purine Nucleosides | 1986 |
Improved synthesis and antitumor activity of 1-deazaadenosine.
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line; Female; HeLa Cells; Humans; Leukemia L1210; Leukemia P388; Mice; Ribonucleosides; Tubercidin; Uterine Cervical Neoplasms | 1987 |
2-Fluoroformycin and 2-aminoformycin. Synthesis and biological activity.
Topics: Adenosine; Adenosine Deaminase; Animals; Antibiotics, Antineoplastic; Formycins; Kinetics; Leukemia L1210; Nucleotides; Phosphates; Substrate Specificity | 1985 |
(+/-)-3-(4-Amino-1H-pyrrolo[2,3-d]pyrimidin-1-yl)-5-(hydroxymethyl)- (1 alpha,2 alpha,3 beta,5 beta)-1,2-cyclopentanediol, the carbocyclic analogue of tubercidin.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Carcinoma, Squamous Cell; Cell Line; Humans; Indicators and Reagents; Laryngeal Neoplasms; Leukemia L1210; Magnetic Resonance Spectroscopy; Mice; Ribonucleosides; Structure-Activity Relationship; Tubercidin | 1984 |
Synthesis and biological evaluation of N4-substituted imidazo- and v-triazolo[4,5-d]pyridazine nucleosides.
Topics: Adenosine Deaminase Inhibitors; Animals; Antineoplastic Agents; Cattle; Humans; Leukemia L1210; Melanoma, Experimental; Mice; Nucleosides; Pyridazines; Structure-Activity Relationship; Tumor Cells, Cultured | 1993 |
The effect of 5-azacytidine and dihydro-5-azacytidine on nuclear ribosomal RNA and poly(A) RNA synthesis in L1210 cells in vitro.
Topics: Adenosine; Animals; Azacitidine; Cells, Cultured; Depression, Chemical; Dose-Response Relationship, Drug; Leukemia L1210; Methionine; Methylation; Mice; Poly A; RNA; RNA, Heterogeneous Nuclear; RNA, Messenger; RNA, Ribosomal; Uridine | 1980 |
Evidence that the inhibitory effect of adenosine, but not cordycepin, on the methylation of nuclear RNA is mediated by S-adenosylhomocysteine hydrolase.
Topics: Adenosine; Adenosylhomocysteinase; Adult; Animals; Cell Nucleus; Deoxyadenosines; Homocysteine; Humans; Hydrolases; Leukemia L1210; Methylation; RNA; S-Adenosylhomocysteine; S-Adenosylmethionine | 1980 |
Kinetic studies of adenosine kinase from L1210 cells: a model enzyme with a two-site ping-pong mechanism.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Kinase; Adenosine Monophosphate; Adenosine Triphosphate; Animals; In Vitro Techniques; Kinetics; Leukemia L1210; Magnesium; Mice; Models, Chemical; Phosphorylation; Phosphotransferases | 1983 |
Synthesis and antiviral evaluation of carbocyclic analogues of ribofuranosides of 2-amino-6-substituted-purines and of 2-amino-6-substituted-8-azapurines.
Topics: Adenosine; Animals; Antiviral Agents; Drug Evaluation, Preclinical; Indicators and Reagents; Leukemia L1210; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Purine Nucleosides; Simplexvirus; Spectrophotometry; Structure-Activity Relationship; Vaccinia virus | 1984 |
The comparative effects of 5'-methylthioadenosine and some of its analogs on cells containing, and deficient in, 5'-methylthioadenosine phosphorylase.
Topics: Adenosine; Animals; Cell Division; Cell Line; Deoxyadenosines; Leukemia L1210; Mice; Mice, Inbred AKR; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Thionucleosides | 1983 |
Metabolism to methionine and growth stimulation by 5'-methylthioadenosine and 5'-methylthioinosine in mammalian cells.
Topics: Adenosine; Animals; B-Lymphocytes; Cell Division; Cell Line; Deoxyadenosines; Humans; Inosine; Leukemia L1210; Methionine; Methylthioinosine; Mice; Thionucleosides | 1983 |
Enhancement of the antitumor activity of N6-(delta 2-isopentenyl)adenosine against cultured L-1210 leukemia cells by pentostatin using a polymeric delivery system.
Topics: Adenosine; Animals; Antineoplastic Agents; Cells, Cultured; Chromatography, High Pressure Liquid; Coformycin; Drug Synergism; Isopentenyladenosine; Leukemia L1210; Mice; Pentostatin; Polymers; Ribonucleosides | 1983 |
Increased cytotoxicity of N6-(delta 2-isopentenyl)adenosine in combination with pentostatin against L-1210 leukemia cells.
Topics: Adenosine; Animals; Antineoplastic Agents; Cell Division; Cells, Cultured; Coformycin; Isopentenyladenosine; Leukemia L1210; Mice; Pentostatin; Ribonucleosides | 1983 |
Reduction of acute adriamycin toxicity in mice treated with adenosine.
Topics: Adenosine; Animals; Body Weight; Dose-Response Relationship, Drug; Doxorubicin; Leukemia L1210; Male; Mice; Mice, Inbred Strains; Time Factors | 1983 |
Specificity of systems mediating transport of adenosine, 9-beta-d-arabinofuranosyl-2-fluoroadenine, and other purine nucleoside analogues in L1210 cells.
Topics: Adenosine; Animals; Biological Transport; Kinetics; Leukemia L1210; Mice; Purine Nucleosides; Temperature; Time Factors; Vidarabine | 1983 |
Initial rate kinetics and evidence for duality of mediated transport of adenosine, related purine nucleosides, and nucleoside analogues in L1210 cells.
Topics: Adenosine; Animals; Biological Transport; Cell Membrane; Kinetics; Leukemia L1210; Mice; Purine Nucleosides; Temperature; Time Factors; Vidarabine | 1983 |
5'-Methylthioadenosine metabolism and methionine synthesis in mammalian cells grown in culture.
Topics: Adenosine; Animals; Breast; Cell Division; Cell Line; Deoxyadenosines; Fibroblasts; HeLa Cells; Humans; Leukemia L1210; Leukemia, Myeloid; Methionine; Mice; Spleen; Thionucleosides | 1982 |
Adenosine stimulation of uphill adenine transport in L1210 leukemia cells. Evidence for a novel countertransport mechanism.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Biological Transport; Coformycin; Dipyridamole; Kinetics; Leukemia L1210; Mice; Mice, Inbred Strains; Pentostatin | 1981 |
Comparison of the effects on cultured L1210 leukemia cells of the ribosyl, 2'-deoxyribosyl, and xylosyl homologs of tubercidin and adenosine alone or in combination with 2'-deoxycoformycin.
Topics: Adenosine; Amino Acids; Animals; Cell Division; Cell Survival; Cells, Cultured; Coformycin; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Leukemia L1210; Mice; Mice, Inbred Strains; Nucleotides; Pentostatin; Ribonucleosides; Tubercidin | 1982 |
Antineoplastic effects of N6-(delta 2-isopentenyl)adenosine against L-1210 mouse lymphocytic leukemic cells using a polymeric delivery system.
Topics: Adenosine; Animals; Antineoplastic Agents; Cells, Cultured; Chromatography, High Pressure Liquid; Isopentenyladenosine; Leukemia L1210; Mice; Polymers | 1982 |
Transport-dependent membrane damage and the irreversible inactivation of nucleoside transport by showdomycin.
Topics: Adenosine; Animals; Antibiotics, Antineoplastic; Biological Transport, Active; Cell Survival; Cells, Cultured; Leukemia L1210; Membranes; Mice; Nucleosides; Showdomycin; Thioinosine; Time Factors | 1981 |
The effect of 5-fluorouracil on the synthesis and methylation of low molecular weight nuclear RNA in L1210 cells.
Topics: Adenosine; Animals; Cell Nucleus; Cells, Cultured; Dose-Response Relationship, Drug; Fluorouracil; Leukemia L1210; Methylation; Mice; Molecular Weight; RNA, Neoplasm; Time Factors | 1980 |
Metabolism of 1,N6-ethenoadenosine.
Topics: Adenine; Adenosine; Animals; Cells, Cultured; Leukemia L1210; Male; Mice; Rats; Sarcoma 180 | 1980 |
Inhibition of methylation of nuclear ribonucleic acid in L1210 cells by tubercidin, 8-azaadenosine and formycin.
Topics: Adenosine; Animals; Antineoplastic Agents; Cell Nucleus; Cells, Cultured; DNA, Neoplasm; Formycins; Leukemia L1210; Methylation; Mice; RNA, Neoplasm; Tubercidin | 1980 |
Showdomycin and its reactive moiety, maleimide. A comparison in selective toxicity and mechanism of action in vitro.
Topics: Adenosine; Animals; Antibiotics, Antineoplastic; Biological Transport; Cell Line; Cysteine; Leukemia L1210; Male; Maleimides; Mice; Nucleosides; Showdomycin | 1980 |
Some short-chain N6-substituted adenosine analogues with antitumor properties.
Topics: Adenosine; Animals; Antineoplastic Agents; Cells, Cultured; Chemical Phenomena; Chemistry; Female; Leukemia L1210; Mice; Neoplasms, Experimental; Rats | 1980 |
3-deaza- and 7-deaza-5'-noraristeromycin and their antiviral properties.
Topics: Adenosine; Animals; Antiviral Agents; Cattle; Cell Division; Cells, Cultured; Chlorocebus aethiops; HeLa Cells; HIV-1; HIV-2; Humans; Leukemia L1210; Male; Methylation; Mice; Microbial Sensitivity Tests; T-Lymphocytes; Vero Cells | 1995 |
Synthesis and cytotoxic activity of 6-vinyl- and 6-ethynyluridine and 8-vinyl-and 8-ethynyladenosine.
Topics: Adenosine; Animals; Antineoplastic Agents; Cell Division; Drug Screening Assays, Antitumor; Humans; Leukemia L1210; Mammary Neoplasms, Experimental; Mice; Organosilicon Compounds; T-Lymphocytes; Tumor Cells, Cultured; Uridine; Vinyl Compounds | 1995 |
Eicar (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide). A novel potent inhibitor of inosinate dehydrogenase activity and guanylate biosynthesis.
Topics: Adenosine; Animals; Antineoplastic Agents; Cell Division; Deoxyguanine Nucleotides; Guanine; Guanosine; Guanosine Triphosphate; Humans; IMP Dehydrogenase; Leukemia L1210; Lymphocytes; Mice; Mycophenolic Acid; Purine Nucleotides; Ribavirin; Ribonucleosides; Ribonucleotides; Tumor Cells, Cultured | 1993 |
Nucleic acid related compounds. 84. Synthesis of 6'-(E and Z)-halohomovinyl derivatives of adenosine, inactivation of S-adenosyl-L-homocysteine hydrolase, and correlation of anticancer and antiviral potencies with enzyme inhibition.
Topics: Adenosine; Adenosylhomocysteinase; Alkynes; Animals; Antineoplastic Agents; Antiviral Agents; Deoxyadenosines; Dideoxyadenosine; Humans; Hydrolases; Leukemia L1210; Mammary Neoplasms, Experimental; Mice; Structure-Activity Relationship; Tumor Cells, Cultured; Vaccinia virus; Vesicular stomatitis Indiana virus | 1994 |
Use of nucleoside kinase-deficient mouse leukemia L1210 cell lines to determine metabolic routes of activation of antitumor nucleoside analogs.
Topics: Adenosine; Adenosine Kinase; Animals; Antineoplastic Agents; Arabinonucleosides; Cell Division; Cytarabine; Deoxyguanosine; Leukemia L1210; Mice; Phosphotransferases (Alcohol Group Acceptor); Substrate Specificity | 1994 |
Antiviral enantiomeric preference for 5'-noraristeromycin.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Antiviral Agents; Humans; Hydrolases; Leukemia L1210; Mice; Microbial Sensitivity Tests; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured | 1994 |
Accumulation and metabolism of adenallene by murine leukemia L1210 cells.
Topics: Adenine; Adenosine; Animals; Antiviral Agents; Biological Transport; Biotransformation; Cytosine; Kinetics; Leukemia L1210; Mice; Temperature; Thymine; Tritium; Tumor Cells, Cultured | 1994 |
Identification of a novel membrane transporter associated with intracellular membranes by phenotypic complementation in the yeast Saccharomyces cerevisiae.
Topics: Adenosine; Amino Acid Sequence; Animals; Base Sequence; Biological Transport; Carrier Proteins; Cell Membrane; DNA Primers; DNA, Complementary; Female; Genetic Complementation Test; Humans; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Mice; Molecular Sequence Data; Oocytes; Phenotype; Polymerase Chain Reaction; Rats; RNA, Messenger; Saccharomyces cerevisiae; Sequence Deletion; Sequence Homology, Amino Acid; Subcellular Fractions; Thymidine; Tumor Cells, Cultured; Uridine; Xenopus laevis | 1996 |
[3H]adenosine transport in DDT1 MF-2 smooth muscle cells: inhibition by metabolites of propentofylline.
Topics: Adenosine; Animals; Binding Sites; Biological Transport; Cricetinae; Dilazep; Dipyridamole; Genital Neoplasms, Male; Kinetics; Leiomyosarcoma; Leukemia L1210; Male; Mesocricetus; Muscle, Smooth; Rats; Thioinosine; Tumor Cells, Cultured; Vas Deferens; Xanthines | 1996 |
Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.
Topics: Adenosine; Adenosylhomocysteinase; Aldehydes; Animals; Antineoplastic Agents; Antiviral Agents; Carbohydrates; Cell Line; Cytomegalovirus; Dogs; Enzyme Inhibitors; Humans; Hydrolases; Leukemia L1210; Mammary Neoplasms, Experimental; Oximes; Tumor Cells, Cultured; Vaccinia virus | 1997 |
Mechanism of natural resistance to N6-(delta2-isopentenyl)adenosine in cultured cells.
Topics: Adenocarcinoma; Adenosine; Alkenes; Animals; Carcinoma, Ehrlich Tumor; Cell Line; Cells, Cultured; Chromatography, Paper; Drug Resistance; Humans; Kidney; Leukemia L1210; Mammary Neoplasms, Experimental; Mice; Pentosyltransferases; Phosphates; Phosphotransferases; Sarcoma 180; Tritium | 1975 |
Nucleoside 5'-monophosphate analogues. Synthesis of 5'-sulfamino-5'-deoxynucleosides.
Topics: Adenosine; Animals; Cells, Cultured; Deoxyadenosines; Enterococcus faecalis; Escherichia coli; Leukemia L1210; Microbial Sensitivity Tests; Simplexvirus; Thymidine; Virus Replication | 1978 |
Cordycepin and xylosyladenine: inhibitors of methylation of nuclear RNA.
Topics: Adenosine; Animals; Cell Nucleus; Deoxyadenosines; Leukemia L1210; Methylation; Mice; RNA, Neoplasm; Xylose | 1978 |
Inhibition of the phosphorylation of nonhistone chromosomal proteins by cordycepin and xylosyladenine in L1210 cells in vitro.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Animals; Chromosomal Proteins, Non-Histone; Coformycin; Deoxyadenosines; In Vitro Techniques; Isoelectric Focusing; Leukemia L1210; Mice; Neoplasm Proteins; Phosphorylation; RNA, Neoplasm; Xylose | 1978 |
Evidence that xylosyladenine affects methylation by inhibition of S-adenosyl-L-methionine synthesis.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Animals; Cell Nucleus; Coformycin; Deoxyadenosines; In Vitro Techniques; Leukemia L1210; Methylation; Mice; RNA, Neoplasm; S-Adenosylmethionine; Xylose | 1979 |
Deoxyribonucleoside triphosphate pools and adenosine toxicity.
Topics: Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Anti-Bacterial Agents; Azepines; Cells, Cultured; Deoxyribonucleotides; Leukemia L1210; Ribonucleosides | 1977 |
Synergism between the antiproliferative activities of arabinosyladenine and N6-benzyladenosine.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Animals; Cell Division; Cells, Cultured; Drug Synergism; Drug Therapy, Combination; Leukemia L1210; Vidarabine | 1977 |
Synthesis and biological activities of some N6- and N9-carbamoyladenines and related ribonucleosides.
Topics: Adenine; Adenosine; Animals; Cell Division; Cell Line; Chemical Phenomena; Chemistry; Leukemia L1210; Mice; Structure-Activity Relationship | 1977 |
Potentiation by 2'-deoxycoformycin of the inhibitory effect of xylosyladenine on nuclear RNA synthesis in L1210 cells in vitro.
Topics: Adenosine; Adenosine Deaminase; Animals; Cell Nucleus; Coformycin; Leukemia L1210; Mice; Ribonucleosides; RNA, Neoplasm; Time Factors; Xylose | 1978 |
Adenosine metabolism in cultured lymphoid cells.
Topics: Adenosine; Adenosine Deaminase; Animals; Cell Survival; Cells, Cultured; Deoxyribonucleosides; DNA, Neoplasm; Formycins; Humans; In Vitro Techniques; Leukemia L1210; Lymphocyte Activation; Lymphocytes; Mice; Neoplasm Proteins; Ribonucleosides; RNA, Neoplasm | 1976 |
Effect of N6-(delta2-isopentenyl)adenosine treatment in vivo on hexokinase activity of mouse L 1210 cells.
Topics: Adenosine; Adenosine Triphosphate; Animals; Cells, Cultured; Glucose; Hexokinase; Hot Temperature; Isoenzymes; Isopentenyladenosine; Kinetics; Leukemia L1210; Mice; Mice, Inbred DBA; Protein Conformation; Protein Denaturation | 1975 |
Synthesis and biological activities of some N6-(nitro- and -aminobenzyl)adenosines.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Animals; Benzyl Compounds; Benzylamines; Cattle; Cell Division; Cells, Cultured; Humans; Intestinal Mucosa; Leukemia L1210; Leukemia, Myeloid, Acute; Mice; Nitro Compounds | 1975 |
L1210/B23.1 cells express equilibrative, inhibitor-sensitive nucleoside transport activity and lack two parental nucleoside transport activities.
Topics: Adenine; Adenosine; Animals; Antiviral Agents; Biological Transport; Carrier Proteins; Cell Membrane; Clone Cells; Formycins; Kinetics; Leukemia L1210; Membrane Proteins; Mice; Mutagenesis; Nucleoside Transport Proteins; Nucleosides; Thioinosine; Thymidine; Tumor Cells, Cultured; Vidarabine | 1992 |
Substrate specificity, kinetics, and stoichiometry of sodium-dependent adenosine transport in L1210/AM mouse leukemia cells.
Topics: 4-Chloromercuribenzenesulfonate; Adenosine; Animals; Biological Transport; Ethylmaleimide; Kinetics; Leukemia L1210; Mice; Showdomycin; Sodium; Substrate Specificity; Temperature; Tumor Cells, Cultured; Vidarabine | 1991 |
Targeting 5'-deoxy-5'-(methylthio)adenosine phosphorylase by 5'-haloalkyl analogues of 5'-deoxy-5'-(methylthio)adenosine.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Antineoplastic Agents; Cell Division; Chemical Phenomena; Chemistry; Deoxyadenosines; Drug Stability; Humans; Hydrolases; Leukemia L1210; Leukemia, Experimental; Liver; Mice; Molecular Structure; Polyamines; Purine-Nucleoside Phosphorylase; Structure-Activity Relationship; Thionucleosides; Tumor Cells, Cultured | 1991 |
Sodium-dependent nucleoside transport in mouse leukemia L1210 cells.
Topics: Adenosine; Animals; Biological Transport; Formycins; Furosemide; Leukemia L1210; Mice; Nucleosides; Nystatin; Sodium; Thioinosine; Tumor Cells, Cultured | 1991 |
Combined modulation of S-adenosylmethionine biosynthesis and S-adenosylhomocysteine metabolism enhances inhibition of nucleic acid methylation and L1210 cell growth.
Topics: Adenosine; Animals; Cell Division; DNA, Neoplasm; Homocysteine; Leukemia L1210; Methylation; Polyamines; RNA, Neoplasm; S-Adenosylhomocysteine; S-Adenosylmethionine; Time Factors | 1990 |
Effects of cytosine arabinoside and hydroxyurea on the synthesis of deoxyribonucleotides and DNA replication in L1210 cells.
Topics: Adenosine; Animals; Cytarabine; Cytidine; Deoxyribonucleotides; DNA Replication; Hydroxyurea; Leukemia L1210; Mice; RNA, Neoplasm; Tumor Cells, Cultured | 1990 |
Antitumor activity of derivatives of neplanocin A in vivo and in vitro.
Topics: Adenosine; Animals; Antibiotics, Antineoplastic; Cells, Cultured; Female; Leucine; Leukemia L1210; Male; Mice; Neoplasms, Experimental; RNA; Sarcoma 180; Uridine | 1986 |
A simple method for predicting modes of actions of antitumor agents.
Topics: Adenosine; Animals; Antineoplastic Agents; DNA Replication; Guanosine; Leukemia L1210; Mitosis; Nucleosides; Protein Synthesis Inhibitors; RNA; Thymidine; Tumor Cells, Cultured; Uridine | 1988 |
Potentiation of cytotoxicity and antitumor activity of adenosine analogs by the adenosine deaminase inhibitor adecypenol.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Animals; Antineoplastic Agents; Cyclopentanes; Deoxyadenosines; Drug Synergism; HeLa Cells; Humans; Leukemia L1210; Mice; Molecular Structure; Nucleoside Deaminases; Purines; Vidarabine | 1989 |
Enantiomeric selectivity of adenosine transport systems in mouse erythrocytes and L1210 cells.
Topics: Adenosine; Animals; Biological Transport; Erythrocyte Membrane; In Vitro Techniques; Kinetics; Leukemia L1210; Mice; Sodium; Stereoisomerism; Thioinosine | 1989 |
Effect of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase, on polyamine metabolism in mammalian cells.
Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Cell Division; Cell Line, Transformed; Deoxyadenosines; Dose-Response Relationship, Drug; Fibroblasts; Leukemia L1210; Mice; Polyamines; S-Adenosylmethionine; Spermine Synthase; Thionucleosides; Transferases; Tumor Cells, Cultured | 1989 |
New fluorinated carbocyclic nucleosides: synthesis and bioactivity.
Topics: Adenosine; Animals; Antineoplastic Agents; Leukemia L1210; Mice; Tumor Cells, Cultured | 1989 |
Syntheses and antitumor activities of N6,N6-dimethyladenosine carboxylate analogues.
Topics: Adenosine; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Division; Chemical Phenomena; Chemistry; Leukemia L1210; Mice; Mice, Inbred ICR; Tumor Cells, Cultured | 1989 |
Metabolic activation of 2,6-diaminopurine and 2,6-diaminopurine-2'-deoxyriboside to antitumor agents.
Topics: Adenosine; Animals; Antineoplastic Agents; Biotransformation; Cell Aggregation; Cell Cycle; Cell Division; Chromatography, High Pressure Liquid; Deoxyadenosines; Kinetics; Leukemia L1210; Mice; Ribonucleotides | 1989 |
Some pharmacological activities of novel adenine-related compounds isolated from a marine sponge Agelas mauritiana.
Topics: Adenine; Adenosine; Animals; Aorta; Cell Cycle; Erythrocytes; In Vitro Techniques; Kinetics; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Mice; Muscle Relaxation; Muscle, Smooth, Vascular; Naphthols; Porifera; Rabbits; Rats; Rats, Inbred Strains; Receptors, Purinergic | 1989 |
Antiproliferative effects of 4',5'-unsaturated adenine nucleosides on leukemia L1210 cells in vitro.
Topics: Adenine Nucleotides; Adenosine; Animals; Antineoplastic Agents; Cell Division; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Cytosine Nucleotides; Guanine Nucleotides; Leukemia L1210; Tumor Cells, Cultured; Uracil Nucleotides | 1989 |
Inhibition of human leukaemic thymidylate kinase and L1210 ribonucleotide reductase by dinucleotides of adenosine and thymidine and their phosphonate analogues.
Topics: Adenosine; Animals; Dose-Response Relationship, Drug; Humans; Kinetics; Leukemia L1210; Leukemia, Myeloid, Acute; Nucleoside-Phosphate Kinase; Oligonucleotides; Organophosphonates; Phosphotransferases; Ribonucleoside Diphosphate Reductase; Ribonucleotide Reductases; Thymidine | 1988 |
Metabolism and metabolic effects of 2-azahypoxanthine and 2-azaadenosine.
Topics: Adenosine; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line; Chromatography, High Pressure Liquid; Deoxyribonucleotides; Humans; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; IMP Dehydrogenase; Laryngeal Neoplasms; Leukemia L1210; Macromolecular Substances; Mice; Polynucleotides; Ribonucleotides | 1985 |
The effects on 4-aminoantifolates on 5-formyltetrahydrofolate metabolism in L1210 cells. A biochemical basis of the selectivity of leucovorin rescue.
Topics: Adenosine; Animals; Cell Division; Floxuridine; Folic Acid; Kinetics; Leucovorin; Leukemia L1210; Mice; Thymidine | 1987 |
Inhibition of utilization of hypoxanthine and guanine in cells treated with the carbocyclic analog of adenosine. Phosphates of carbocyclic nucleoside analogs as inhibitors of hypoxanthine (guanine) phosphoribosyltransferase.
Topics: Adenosine; Animals; Carcinoma, Squamous Cell; Cell Line; Coformycin; Colonic Neoplasms; Cyclic GMP; Cyclic IMP; Guanine; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Inosine Nucleotides; Kinetics; Leukemia L1210; Mice; Pentosyltransferases; Ribonucleotides | 1985 |
Properties of L1210 cells resistant to alpha-difluoromethylornithine.
Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Deoxyadenosines; Drug Resistance; Eflornithine; Leukemia L1210; Ornithine Decarboxylase; Polyamines; Putrescine; RNA, Messenger; Thionucleosides; Tumor Cells, Cultured | 1988 |
Effect of inhibitors of S-adenosylmethionine decarboxylase on the contents of ornithine decarboxylase and S-adenosylmethionine decarboxylase in L1210 cells.
Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Deoxyadenosines; Leukemia L1210; Ornithine Decarboxylase; Polyamines; Proteins; RNA, Messenger; Spermidine; Spermine; Tumor Cells, Cultured | 1988 |
Effect of inhibitors of S-adenosylmethionine decarboxylase on polyamine content and growth of L1210 cells.
Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cell Division; Cells, Cultured; Deoxyadenosines; Enzyme Inhibitors; Kinetics; Leukemia L1210; Male; Mice; Polyamines; Prostate; Rats; Structure-Activity Relationship | 1988 |
Preparation and antileukemic screening of some new 6'-deoxyhexopyranosyladenine nucleosides.
Topics: Adenosine; Animals; Chemical Phenomena; Chemistry; Deoxyribonucleosides; Leukemia L1210; Mice; Molecular Conformation; Structure-Activity Relationship | 1987 |
Differences in the metabolism and metabolic effects of the carbocyclic adenosine analogs, neplanocin A and aristeromycin.
Topics: Adenosine; Adenosine Deaminase; Adenosine Triphosphate; AMP Deaminase; Animals; Cell Division; Cell Line; Guanine; Guanosine Triphosphate; Hypoxanthine; Hypoxanthines; Isomerism; Kinetics; Leukemia L1210; Mice | 1986 |
Synthesis and biological properties of 9-(trans-4-hydroxy-2-buten-1-yl)adenine and guanine: open-chain analogues of neplanocin A.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Antibiotics, Antineoplastic; Guanine; Indicators and Reagents; Leukemia L1210; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 1987 |
Studies on compounds related to antitumor agents. Synthesis of 8-substituted N6,N6-dimethyladenosine derivatives.
Topics: Adenosine; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Chemical Phenomena; Chemistry; Leukemia L1210; Mice | 1986 |
Effects of nucleoside transport inhibitors on the salvage and toxicity of adenosine and deoxyadenosine in L1210 and P388 mouse leukemia cells.
Topics: Adenosine; Animals; Biological Transport; Coformycin; Deoxyadenosines; Dipyridamole; Inosine; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Mice; Pentostatin; Thioinosine | 1985 |
5'-Deoxy-5'-methylthioadenosine phosphorylase--III. Role of the enzyme in the metabolism and action of 5'-halogenated adenosine analogs.
Topics: Adenine Nucleotides; Adenosine; Animals; Antineoplastic Agents; Biotransformation; Cell Line; Deoxyadenosines; Humans; Kinetics; Leukemia L1210; Leukemia L5178; Leukemia, Experimental; Mice; Pentosyltransferases; Purine-Nucleoside Phosphorylase | 1985 |
Biochemical mode of cytotoxic action of neplanocin A in L1210 leukemic cells.
Topics: Adenosine; Adenosine Kinase; Animals; Biotransformation; Cell Survival; DNA, Neoplasm; Drug Resistance; Kinetics; Leukemia L1210; Leukemia P388; Mice; RNA, Neoplasm | 1986 |
Synthesis and biological activity of a novel adenosine analogue, 3-beta-D-ribofuranosylthieno[2,3-d]pyrimidin-4-one.
Topics: Adenosine; Adenosine Kinase; Animals; Antineoplastic Agents; Biotransformation; In Vitro Techniques; Leukemia L1210; Mice; Pyrimidine Nucleosides | 1985 |
Analogs of 5'-deoxy-5'-(methylthio)adenosine.
Topics: Adenosine; Animals; Antineoplastic Agents; Carcinoma; Carcinoma, Squamous Cell; Cell Line; Humans; Laryngeal Neoplasms; Leukemia L1210; Mice; Mouth Neoplasms; Structure-Activity Relationship; Sulfides | 1974 |
N 6 -Substituted adenosines: synthesis, biological activity, and some structure-activity relationships.
Topics: Adenocarcinoma; Adenosine; Animals; Antineoplastic Agents; Cells, Cultured; Chromatography, Paper; Escherichia coli; Female; Leukemia L1210; Mammary Neoplasms, Experimental; Mice; Nicotiana; Optical Rotation; Plants, Toxic; Sarcoma 180; Spectrum Analysis; Structure-Activity Relationship; Ultraviolet Rays | 1972 |
Synthesis and biological activity of selected 2,6-disubstituted-(2-deoxy- -and- -D-erythro-pentofuranosyl)purines.
Topics: Adenosine; Animals; Cells, Cultured; Deoxyadenosines; Depression, Chemical; Enterococcus faecalis; Escherichia coli; Leukemia L1210; Magnetic Resonance Spectroscopy; Nucleosides; Optical Rotation; Purine Nucleotides; Purines; Spectrum Analysis; Stereoisomerism; Structure-Activity Relationship; Ultraviolet Rays | 1972 |
Effects of persantin on several transport systems of murine leukemias.
Topics: Adenine; Adenosine; Amino Acids; Animals; Biological Transport; Cell Line; Cyclopentanes; Cytidine; Depression, Chemical; Dipyridamole; Fucose; Glucose; Glycerol; Leukemia L1210; Leukemia, Experimental; Mice; Phosphates; Uracil; Uridine | 1972 |
Antitumor activity of N6-phenyladenosine, and inhibitor of adenosine utilization, in combination with related purine analogs.
Topics: Adenosine; Animals; Benzene Derivatives; Carcinoma 256, Walker; Cell Division; Cells, Cultured; Drug Synergism; Evaluation Studies as Topic; Leukemia L1210; Mercaptopurine; Mice; Mice, Inbred DBA; Rats; Sarcoma 180; Thioguanine | 1973 |
Stimulation of ornithine decarboxylase activity and inhibition of S-adenosyl-L-methionine decarboxylase activity in leukaemic mice by methylglyoxal bis(guanylhydrazone).
Topics: Adenosine; Amidines; Animals; Carboxy-Lyases; Depression, Chemical; Glyoxal; Hydrazones; Leukemia L1210; Male; Methionine; Mice; Ornithine; Polyamines; S-Adenosylmethionine; Spermidine; Stimulation, Chemical | 1973 |
Inhibition of protein synthesis by 5'-sulfamoyladenosine.
Topics: Adenine Nucleotides; Adenosine; Aminohydrolases; Animals; Bacterial Proteins; Carbon Isotopes; Cells, Cultured; Deoxyadenosines; DNA, Bacterial; Escherichia coli; Inosine; Intestinal Mucosa; Leukemia L1210; Lysine; Mice; Muscles; Nucleosides; Phenylalanine; Proline; Rabbits; Rats; RNA, Bacterial; RNA, Transfer; Streptococcus; Structure-Activity Relationship; Sulfonamides | 1971 |
Tissue-specific effects of N 6 -( 2 -isopentenyl) adenosine on the incorporation of precursors into nucleic acids and protein in rats and mice.
Topics: Adenosine; Alkenes; Animals; Cell Division; DNA; Female; Intestinal Mucosa; Leukemia L1210; Liver; Mice; Mice, Inbred Strains; Nucleic Acids; Phenylalanine; Proteins; Rats; Rats, Inbred Strains; RNA; Spleen; Thymidine; Thymus Gland; Time Factors; Tritium; Uridine | 1972 |
Deamination of arabinosyladenine by adenosine deaminase and inhibition by arabinosyl-6-mercaptopurine.
Topics: Adenine; Adenosine; Aminohydrolases; Animals; Antibiotics, Antineoplastic; Arabinose; Cell Fractionation; Cell Line; Deamination; Drug Resistance; Female; Leukemia L1210; Mercaptopurine; Mice; Mice, Inbred Strains; Mutation; Nucleosides | 1972 |