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adenosine and Leukemia L 1210

adenosine has been researched along with Leukemia L 1210 in 88 studies

Research

Studies (88)

TimeframeStudies, this research(%)All Research%
pre-199071 (80.68)18.7374
1990's17 (19.32)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Allan, PW; Bennett, LL; Chang, CH; Montgomery, JA; Rose, LM; Secrist, JA1
Bordoni, T; Cristalli, G; Franchetti, P; Geroni, C; Grifantini, M; Vittori, S1
Montgomery, JA; Secrist, JA; Shortnacy, AT1
Clayton, SJ; Montgomery, JA; Secrist, JA1
Bussolari, JC; Chen, SF; Panzica, RP; Ramesh, K; Stoeckler, JD1
Abbasi, MM; Beisler, JA; Glazer, RI; Peale, AL1
Glazer, RI; Hartman, KD2
Bennett, LL; Brockman, RW; Cha, S; Chang, CH1
Arnett, G; Clayton, JD; Shannon, WM; Shealy, YF1
Ferro, AJ; Riscoe, MK; White, MW1
Carson, DA; Kamatani, N; Willis, EH1
Chang, Y; Hacker, B3
Hacker, MP; Newman, RA1
Chello, PL; Dorick, DM; Montgomery, JA; Sirotnak, FM1
Chello, PL; Dorick, DM; Montgomery, JA; Sirotnak, FM; Yang, CH1
Backlund, PS; Smith, RA1
Cybulski, RL; Fry, DW; Goldman, ID1
Cass, CE; Muhs, WH; Robins, MJ; Selner, M; Tan, TH1
Rabinovitz, M; Uehara, Y1
Chheda, GB; Dutta, SP; Mittelman, A1
Glazer, RI; Stern, HJ1
Fisher, JM; Rabinovitz, M; Uehara, Y1
Bernacki, RJ; Bullard, GA; Fleysher, MH1
Andrei, G; Balzarini, J; Chen, X; De Clercq, E; Ikeda, S; Rao, J; Schneller, SW; Siddiqi, SM; Snoeck, R1
Balzarini, J; Baraldi, PG; Bazzanini, R; De Clercq, E; Manfredini, S; Marangoni, M; Simoni, D1
Balzarini, J; Bohman, C; De Clercq, E; Fridland, A; Herdewijn, P; Horská, K; Karlsson, A; Van Aerschot, A; Votruba, I; Wang, L1
Balzarini, J; Borchardt, RT; De Clercq, E; Robins, MJ; Wnuk, SF; Yuan, CS2
Cory, AH; Cory, JG1
Andrei, G; Balzarini, J; Chen, X; De Clercq, E; Ikeda, S; Schneller, SW; Siddiqi, SM; Snoeck, R1
Kessel, D; Zemlicka, J1
Cass, CE; Ellison, MJ; Hogue, DL; Young, JD1
Geiger, JD; Mukherjee, K; Parkinson, FE1
Hakala, MT; Slocum, HK1
Dethmers, JK; Lemmen, KL; Lemmen, LJ; Mungall, WS; Norling, LL1
Glazer, RI; Peale, AL3
Glazer, RI; Legraverend, M1
Harrap, KR; Smyth, JF1
Mittelman, A; Nechaev, A; Tritsch, GL1
Chheda, GB; Cox, C; Dutta, SP; Hong, CI; Parthasarthy, R; Tritsch, GL1
Harrap, KR; Paine, RM1
Shavelson, LJ; Tritsch, GL1
Chheda, GB; Cox, C; Dutta, SP; Tritsch, GL1
Belt, JA; Cass, CE; Dagnino, L; Gati, WP; Paterson, AR; Vijayalakshmi, D1
Bennett, LL; Dagnino, L; Paterson, AR2
Bernacki, RJ; Borchardt, RT; Kramer, DL; Lee, YH; Libby, PR; Miller, JT; Porter, CW; Spiess, AJ; Sufrin, JR1
Borchardt, RT; Kramer, DL; Porter, CW; Sufrin, JR1
Cory, JG; Matsumoto, M; Rey, DA1
Fukukawa, K; Hoshi, A; Iigo, M; Tokuzen, R; Ueda, T; Yoshida, M1
Fukuyasu, H; Hoshi, A; Kazuno, Y; Nakajima, S; Sato, Y; Yoshida, M1
Kawakami, T; Komiyama, K; Omura, S; Tanaka, H; Yang, ZB1
Dagnino, L; Gati, WP; Paterson, AR1
Coward, JK; Pegg, AE; Poulin, R; Wechter, R; Woster, PM1
Matsumura, Y; Morizawa, Y; Nakayama, T; Uchida, K; Yasuda, A1
Arakawa, E; Kato, T; Ogawa, S; Suzumura, Y; Takamura, T1
Cory, JG; Weckbecker, G1
Allen, TM; Baer, HP; Cass, CE; Clanachan, AS; Cook, DA; Fathi-Afshar, R; Krueger, CA; Vriend, R1
Gaetjens, E; Lerner, LM; Sheid, B2
Davies, LC; Harrap, KR; Orr, RM; Powles, RL; Stock, JA; Taylor, GA1
Adamson, DJ; Bennett, LL; Rose, LM; Shaddix, SC; Smithers, D; Thomas, HJ1
Barlowe, CK; Goldman, ID; Matherly, LH; Phillips, VM1
Allan, PW; Bennett, LL; Brockman, RW; Clayton, JD; Rose, LM; Shaddix, SC; Shealy, YF1
Madhubala, R; Pegg, AE; Secrist, JA2
Jones, DB; Pegg, AE; Secrist, JA1
Allan, PW; Bennett, LL; Comber, RN; Rose, LM; Secrist, JA1
Phadtare, S; Zemlicka, J1
Arakawa, E; Kato, T; Ogawa, S; Suzumura, Y1
Plagemann, PG; Wohlhueter, RM1
Chu, MY; Chu, SH; Parks, RE; Savarese, TM1
Inaba, M; Nagashima, K; Sakurai, Y; Tsukagoshi, S1
Bloomer, LC; Patil, VD; Townsend, LB; Wise, DS; Wotring, LL1
Montgomery, JA; Shortnacy, AT; Thomas, HJ1
Fleysher, MH1
Bloch, A; Broom, AD; Christensen, LF; Robins, MJ1
Dodd, DC; Kessel, D1
Divekar, AY; Grindey, GB; Hakala, MT1
Heby, O; Russell, DH; Sauter, S1
Bloch, A; Coutsogeorgopoulos, C1
Mihich, E; Rustum, Y1
Chao, DL; Kimball, AP1

Other Studies

88 other study(ies) available for adenosine and Leukemia L 1210

ArticleYear
Synthesis and biochemical properties of 8-amino-6-fluoro-9-beta-D-ribofuranosyl-9H-purine.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:10

    Topics: Adenosine Deaminase Inhibitors; AMP Deaminase; Animals; Antineoplastic Agents; Cell Line; Cell Survival; Coformycin; Inosine Monophosphate; Kinetics; Leukemia L1210; Pentostatin; Purine Nucleosides

1986
Improved synthesis and antitumor activity of 1-deazaadenosine.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:9

    Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line; Female; HeLa Cells; Humans; Leukemia L1210; Leukemia P388; Mice; Ribonucleosides; Tubercidin; Uterine Cervical Neoplasms

1987
2-Fluoroformycin and 2-aminoformycin. Synthesis and biological activity.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:11

    Topics: Adenosine; Adenosine Deaminase; Animals; Antibiotics, Antineoplastic; Formycins; Kinetics; Leukemia L1210; Nucleotides; Phosphates; Substrate Specificity

1985
(+/-)-3-(4-Amino-1H-pyrrolo[2,3-d]pyrimidin-1-yl)-5-(hydroxymethyl)- (1 alpha,2 alpha,3 beta,5 beta)-1,2-cyclopentanediol, the carbocyclic analogue of tubercidin.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:4

    Topics: Animals; Antineoplastic Agents; Antiviral Agents; Carcinoma, Squamous Cell; Cell Line; Humans; Indicators and Reagents; Laryngeal Neoplasms; Leukemia L1210; Magnetic Resonance Spectroscopy; Mice; Ribonucleosides; Structure-Activity Relationship; Tubercidin

1984
Synthesis and biological evaluation of N4-substituted imidazo- and v-triazolo[4,5-d]pyridazine nucleosides.
    Journal of medicinal chemistry, 1993, Dec-10, Volume: 36, Issue:25

    Topics: Adenosine Deaminase Inhibitors; Animals; Antineoplastic Agents; Cattle; Humans; Leukemia L1210; Melanoma, Experimental; Mice; Nucleosides; Pyridazines; Structure-Activity Relationship; Tumor Cells, Cultured

1993
The effect of 5-azacytidine and dihydro-5-azacytidine on nuclear ribosomal RNA and poly(A) RNA synthesis in L1210 cells in vitro.
    Molecular pharmacology, 1980, Volume: 17, Issue:1

    Topics: Adenosine; Animals; Azacitidine; Cells, Cultured; Depression, Chemical; Dose-Response Relationship, Drug; Leukemia L1210; Methionine; Methylation; Mice; Poly A; RNA; RNA, Heterogeneous Nuclear; RNA, Messenger; RNA, Ribosomal; Uridine

1980
Evidence that the inhibitory effect of adenosine, but not cordycepin, on the methylation of nuclear RNA is mediated by S-adenosylhomocysteine hydrolase.
    Molecular pharmacology, 1980, Volume: 18, Issue:3

    Topics: Adenosine; Adenosylhomocysteinase; Adult; Animals; Cell Nucleus; Deoxyadenosines; Homocysteine; Humans; Hydrolases; Leukemia L1210; Methylation; RNA; S-Adenosylhomocysteine; S-Adenosylmethionine

1980
Kinetic studies of adenosine kinase from L1210 cells: a model enzyme with a two-site ping-pong mechanism.
    Biochemistry, 1983, Feb-01, Volume: 22, Issue:3

    Topics: Adenosine; Adenosine Diphosphate; Adenosine Kinase; Adenosine Monophosphate; Adenosine Triphosphate; Animals; In Vitro Techniques; Kinetics; Leukemia L1210; Magnesium; Mice; Models, Chemical; Phosphorylation; Phosphotransferases

1983
Synthesis and antiviral evaluation of carbocyclic analogues of ribofuranosides of 2-amino-6-substituted-purines and of 2-amino-6-substituted-8-azapurines.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:5

    Topics: Adenosine; Animals; Antiviral Agents; Drug Evaluation, Preclinical; Indicators and Reagents; Leukemia L1210; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Purine Nucleosides; Simplexvirus; Spectrophotometry; Structure-Activity Relationship; Vaccinia virus

1984
The comparative effects of 5'-methylthioadenosine and some of its analogs on cells containing, and deficient in, 5'-methylthioadenosine phosphorylase.
    Biochimica et biophysica acta, 1983, Jun-02, Volume: 762, Issue:3

    Topics: Adenosine; Animals; Cell Division; Cell Line; Deoxyadenosines; Leukemia L1210; Mice; Mice, Inbred AKR; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Thionucleosides

1983
Metabolism to methionine and growth stimulation by 5'-methylthioadenosine and 5'-methylthioinosine in mammalian cells.
    Biochemical and biophysical research communications, 1983, Apr-29, Volume: 112, Issue:2

    Topics: Adenosine; Animals; B-Lymphocytes; Cell Division; Cell Line; Deoxyadenosines; Humans; Inosine; Leukemia L1210; Methionine; Methylthioinosine; Mice; Thionucleosides

1983
Enhancement of the antitumor activity of N6-(delta 2-isopentenyl)adenosine against cultured L-1210 leukemia cells by pentostatin using a polymeric delivery system.
    Journal of pharmaceutical sciences, 1983, Volume: 72, Issue:8

    Topics: Adenosine; Animals; Antineoplastic Agents; Cells, Cultured; Chromatography, High Pressure Liquid; Coformycin; Drug Synergism; Isopentenyladenosine; Leukemia L1210; Mice; Pentostatin; Polymers; Ribonucleosides

1983
Increased cytotoxicity of N6-(delta 2-isopentenyl)adenosine in combination with pentostatin against L-1210 leukemia cells.
    Journal of pharmaceutical sciences, 1983, Volume: 72, Issue:10

    Topics: Adenosine; Animals; Antineoplastic Agents; Cell Division; Cells, Cultured; Coformycin; Isopentenyladenosine; Leukemia L1210; Mice; Pentostatin; Ribonucleosides

1983
Reduction of acute adriamycin toxicity in mice treated with adenosine.
    European journal of cancer & clinical oncology, 1983, Volume: 19, Issue:8

    Topics: Adenosine; Animals; Body Weight; Dose-Response Relationship, Drug; Doxorubicin; Leukemia L1210; Male; Mice; Mice, Inbred Strains; Time Factors

1983
Specificity of systems mediating transport of adenosine, 9-beta-d-arabinofuranosyl-2-fluoroadenine, and other purine nucleoside analogues in L1210 cells.
    Cancer research, 1983, Volume: 43, Issue:1

    Topics: Adenosine; Animals; Biological Transport; Kinetics; Leukemia L1210; Mice; Purine Nucleosides; Temperature; Time Factors; Vidarabine

1983
Initial rate kinetics and evidence for duality of mediated transport of adenosine, related purine nucleosides, and nucleoside analogues in L1210 cells.
    Cancer research, 1983, Volume: 43, Issue:1

    Topics: Adenosine; Animals; Biological Transport; Cell Membrane; Kinetics; Leukemia L1210; Mice; Purine Nucleosides; Temperature; Time Factors; Vidarabine

1983
5'-Methylthioadenosine metabolism and methionine synthesis in mammalian cells grown in culture.
    Biochemical and biophysical research communications, 1982, Sep-30, Volume: 108, Issue:2

    Topics: Adenosine; Animals; Breast; Cell Division; Cell Line; Deoxyadenosines; Fibroblasts; HeLa Cells; Humans; Leukemia L1210; Leukemia, Myeloid; Methionine; Mice; Spleen; Thionucleosides

1982
Adenosine stimulation of uphill adenine transport in L1210 leukemia cells. Evidence for a novel countertransport mechanism.
    The Journal of biological chemistry, 1981, May-10, Volume: 256, Issue:9

    Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Biological Transport; Coformycin; Dipyridamole; Kinetics; Leukemia L1210; Mice; Mice, Inbred Strains; Pentostatin

1981
Comparison of the effects on cultured L1210 leukemia cells of the ribosyl, 2'-deoxyribosyl, and xylosyl homologs of tubercidin and adenosine alone or in combination with 2'-deoxycoformycin.
    Cancer treatment reports, 1982, Volume: 66, Issue:2

    Topics: Adenosine; Amino Acids; Animals; Cell Division; Cell Survival; Cells, Cultured; Coformycin; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Leukemia L1210; Mice; Mice, Inbred Strains; Nucleotides; Pentostatin; Ribonucleosides; Tubercidin

1982
Antineoplastic effects of N6-(delta 2-isopentenyl)adenosine against L-1210 mouse lymphocytic leukemic cells using a polymeric delivery system.
    Journal of pharmaceutical sciences, 1982, Volume: 71, Issue:3

    Topics: Adenosine; Animals; Antineoplastic Agents; Cells, Cultured; Chromatography, High Pressure Liquid; Isopentenyladenosine; Leukemia L1210; Mice; Polymers

1982
Transport-dependent membrane damage and the irreversible inactivation of nucleoside transport by showdomycin.
    Biochemical pharmacology, 1981, Dec-01, Volume: 30, Issue:23

    Topics: Adenosine; Animals; Antibiotics, Antineoplastic; Biological Transport, Active; Cell Survival; Cells, Cultured; Leukemia L1210; Membranes; Mice; Nucleosides; Showdomycin; Thioinosine; Time Factors

1981
The effect of 5-fluorouracil on the synthesis and methylation of low molecular weight nuclear RNA in L1210 cells.
    Molecular pharmacology, 1980, Volume: 17, Issue:2

    Topics: Adenosine; Animals; Cell Nucleus; Cells, Cultured; Dose-Response Relationship, Drug; Fluorouracil; Leukemia L1210; Methylation; Mice; Molecular Weight; RNA, Neoplasm; Time Factors

1980
Metabolism of 1,N6-ethenoadenosine.
    Biochemical medicine, 1980, Volume: 23, Issue:2

    Topics: Adenine; Adenosine; Animals; Cells, Cultured; Leukemia L1210; Male; Mice; Rats; Sarcoma 180

1980
Inhibition of methylation of nuclear ribonucleic acid in L1210 cells by tubercidin, 8-azaadenosine and formycin.
    Biochemical pharmacology, 1980, Jun-01, Volume: 29, Issue:11

    Topics: Adenosine; Animals; Antineoplastic Agents; Cell Nucleus; Cells, Cultured; DNA, Neoplasm; Formycins; Leukemia L1210; Methylation; Mice; RNA, Neoplasm; Tubercidin

1980
Showdomycin and its reactive moiety, maleimide. A comparison in selective toxicity and mechanism of action in vitro.
    Biochemical pharmacology, 1980, Aug-15, Volume: 29, Issue:16

    Topics: Adenosine; Animals; Antibiotics, Antineoplastic; Biological Transport; Cell Line; Cysteine; Leukemia L1210; Male; Maleimides; Mice; Nucleosides; Showdomycin

1980
Some short-chain N6-substituted adenosine analogues with antitumor properties.
    Journal of medicinal chemistry, 1980, Volume: 23, Issue:12

    Topics: Adenosine; Animals; Antineoplastic Agents; Cells, Cultured; Chemical Phenomena; Chemistry; Female; Leukemia L1210; Mice; Neoplasms, Experimental; Rats

1980
3-deaza- and 7-deaza-5'-noraristeromycin and their antiviral properties.
    Journal of medicinal chemistry, 1995, Mar-17, Volume: 38, Issue:6

    Topics: Adenosine; Animals; Antiviral Agents; Cattle; Cell Division; Cells, Cultured; Chlorocebus aethiops; HeLa Cells; HIV-1; HIV-2; Humans; Leukemia L1210; Male; Methylation; Mice; Microbial Sensitivity Tests; T-Lymphocytes; Vero Cells

1995
Synthesis and cytotoxic activity of 6-vinyl- and 6-ethynyluridine and 8-vinyl-and 8-ethynyladenosine.
    Journal of medicinal chemistry, 1995, Jan-06, Volume: 38, Issue:1

    Topics: Adenosine; Animals; Antineoplastic Agents; Cell Division; Drug Screening Assays, Antitumor; Humans; Leukemia L1210; Mammary Neoplasms, Experimental; Mice; Organosilicon Compounds; T-Lymphocytes; Tumor Cells, Cultured; Uridine; Vinyl Compounds

1995
Eicar (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide). A novel potent inhibitor of inosinate dehydrogenase activity and guanylate biosynthesis.
    The Journal of biological chemistry, 1993, Nov-25, Volume: 268, Issue:33

    Topics: Adenosine; Animals; Antineoplastic Agents; Cell Division; Deoxyguanine Nucleotides; Guanine; Guanosine; Guanosine Triphosphate; Humans; IMP Dehydrogenase; Leukemia L1210; Lymphocytes; Mice; Mycophenolic Acid; Purine Nucleotides; Ribavirin; Ribonucleosides; Ribonucleotides; Tumor Cells, Cultured

1993
Nucleic acid related compounds. 84. Synthesis of 6'-(E and Z)-halohomovinyl derivatives of adenosine, inactivation of S-adenosyl-L-homocysteine hydrolase, and correlation of anticancer and antiviral potencies with enzyme inhibition.
    Journal of medicinal chemistry, 1994, Oct-14, Volume: 37, Issue:21

    Topics: Adenosine; Adenosylhomocysteinase; Alkynes; Animals; Antineoplastic Agents; Antiviral Agents; Deoxyadenosines; Dideoxyadenosine; Humans; Hydrolases; Leukemia L1210; Mammary Neoplasms, Experimental; Mice; Structure-Activity Relationship; Tumor Cells, Cultured; Vaccinia virus; Vesicular stomatitis Indiana virus

1994
Use of nucleoside kinase-deficient mouse leukemia L1210 cell lines to determine metabolic routes of activation of antitumor nucleoside analogs.
    Advances in enzyme regulation, 1994, Volume: 34

    Topics: Adenosine; Adenosine Kinase; Animals; Antineoplastic Agents; Arabinonucleosides; Cell Division; Cytarabine; Deoxyguanosine; Leukemia L1210; Mice; Phosphotransferases (Alcohol Group Acceptor); Substrate Specificity

1994
Antiviral enantiomeric preference for 5'-noraristeromycin.
    Journal of medicinal chemistry, 1994, Feb-18, Volume: 37, Issue:4

    Topics: Adenosine; Adenosylhomocysteinase; Animals; Antiviral Agents; Humans; Hydrolases; Leukemia L1210; Mice; Microbial Sensitivity Tests; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured

1994
Accumulation and metabolism of adenallene by murine leukemia L1210 cells.
    Archives of biochemistry and biophysics, 1994, Volume: 308, Issue:1

    Topics: Adenine; Adenosine; Animals; Antiviral Agents; Biological Transport; Biotransformation; Cytosine; Kinetics; Leukemia L1210; Mice; Temperature; Thymine; Tritium; Tumor Cells, Cultured

1994
Identification of a novel membrane transporter associated with intracellular membranes by phenotypic complementation in the yeast Saccharomyces cerevisiae.
    The Journal of biological chemistry, 1996, Apr-19, Volume: 271, Issue:16

    Topics: Adenosine; Amino Acid Sequence; Animals; Base Sequence; Biological Transport; Carrier Proteins; Cell Membrane; DNA Primers; DNA, Complementary; Female; Genetic Complementation Test; Humans; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Mice; Molecular Sequence Data; Oocytes; Phenotype; Polymerase Chain Reaction; Rats; RNA, Messenger; Saccharomyces cerevisiae; Sequence Deletion; Sequence Homology, Amino Acid; Subcellular Fractions; Thymidine; Tumor Cells, Cultured; Uridine; Xenopus laevis

1996
[3H]adenosine transport in DDT1 MF-2 smooth muscle cells: inhibition by metabolites of propentofylline.
    European journal of pharmacology, 1996, Jul-11, Volume: 308, Issue:1

    Topics: Adenosine; Animals; Binding Sites; Biological Transport; Cricetinae; Dilazep; Dipyridamole; Genital Neoplasms, Male; Kinetics; Leiomyosarcoma; Leukemia L1210; Male; Mesocricetus; Muscle, Smooth; Rats; Thioinosine; Tumor Cells, Cultured; Vas Deferens; Xanthines

1996
Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.
    Journal of medicinal chemistry, 1997, May-23, Volume: 40, Issue:11

    Topics: Adenosine; Adenosylhomocysteinase; Aldehydes; Animals; Antineoplastic Agents; Antiviral Agents; Carbohydrates; Cell Line; Cytomegalovirus; Dogs; Enzyme Inhibitors; Humans; Hydrolases; Leukemia L1210; Mammary Neoplasms, Experimental; Oximes; Tumor Cells, Cultured; Vaccinia virus

1997
Mechanism of natural resistance to N6-(delta2-isopentenyl)adenosine in cultured cells.
    Cancer research, 1975, Volume: 35, Issue:2

    Topics: Adenocarcinoma; Adenosine; Alkenes; Animals; Carcinoma, Ehrlich Tumor; Cell Line; Cells, Cultured; Chromatography, Paper; Drug Resistance; Humans; Kidney; Leukemia L1210; Mammary Neoplasms, Experimental; Mice; Pentosyltransferases; Phosphates; Phosphotransferases; Sarcoma 180; Tritium

1975
Nucleoside 5'-monophosphate analogues. Synthesis of 5'-sulfamino-5'-deoxynucleosides.
    Journal of medicinal chemistry, 1978, Volume: 21, Issue:7

    Topics: Adenosine; Animals; Cells, Cultured; Deoxyadenosines; Enterococcus faecalis; Escherichia coli; Leukemia L1210; Microbial Sensitivity Tests; Simplexvirus; Thymidine; Virus Replication

1978
Cordycepin and xylosyladenine: inhibitors of methylation of nuclear RNA.
    Biochemical and biophysical research communications, 1978, Mar-30, Volume: 81, Issue:2

    Topics: Adenosine; Animals; Cell Nucleus; Deoxyadenosines; Leukemia L1210; Methylation; Mice; RNA, Neoplasm; Xylose

1978
Inhibition of the phosphorylation of nonhistone chromosomal proteins by cordycepin and xylosyladenine in L1210 cells in vitro.
    Molecular pharmacology, 1978, Volume: 14, Issue:6

    Topics: Adenosine; Adenosine Deaminase Inhibitors; Animals; Chromosomal Proteins, Non-Histone; Coformycin; Deoxyadenosines; In Vitro Techniques; Isoelectric Focusing; Leukemia L1210; Mice; Neoplasm Proteins; Phosphorylation; RNA, Neoplasm; Xylose

1978
Evidence that xylosyladenine affects methylation by inhibition of S-adenosyl-L-methionine synthesis.
    Cancer letters, 1979, Volume: 6, Issue:4-5

    Topics: Adenosine; Adenosine Deaminase Inhibitors; Animals; Cell Nucleus; Coformycin; Deoxyadenosines; In Vitro Techniques; Leukemia L1210; Methylation; Mice; RNA, Neoplasm; S-Adenosylmethionine; Xylose

1979
Deoxyribonucleoside triphosphate pools and adenosine toxicity.
    Biochemical pharmacology, 1977, Dec-15, Volume: 26, Issue:24

    Topics: Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Anti-Bacterial Agents; Azepines; Cells, Cultured; Deoxyribonucleotides; Leukemia L1210; Ribonucleosides

1977
Synergism between the antiproliferative activities of arabinosyladenine and N6-benzyladenosine.
    Cancer biochemistry biophysics, 1977, Volume: 2, Issue:2

    Topics: Adenosine; Adenosine Deaminase Inhibitors; Animals; Cell Division; Cells, Cultured; Drug Synergism; Drug Therapy, Combination; Leukemia L1210; Vidarabine

1977
Synthesis and biological activities of some N6- and N9-carbamoyladenines and related ribonucleosides.
    Journal of medicinal chemistry, 1977, Volume: 20, Issue:12

    Topics: Adenine; Adenosine; Animals; Cell Division; Cell Line; Chemical Phenomena; Chemistry; Leukemia L1210; Mice; Structure-Activity Relationship

1977
Potentiation by 2'-deoxycoformycin of the inhibitory effect of xylosyladenine on nuclear RNA synthesis in L1210 cells in vitro.
    Biochemical pharmacology, 1978, Volume: 27, Issue:21

    Topics: Adenosine; Adenosine Deaminase; Animals; Cell Nucleus; Coformycin; Leukemia L1210; Mice; Ribonucleosides; RNA, Neoplasm; Time Factors; Xylose

1978
Adenosine metabolism in cultured lymphoid cells.
    Advances in enzyme regulation, 1976, Volume: 15

    Topics: Adenosine; Adenosine Deaminase; Animals; Cell Survival; Cells, Cultured; Deoxyribonucleosides; DNA, Neoplasm; Formycins; Humans; In Vitro Techniques; Leukemia L1210; Lymphocyte Activation; Lymphocytes; Mice; Neoplasm Proteins; Ribonucleosides; RNA, Neoplasm

1976
Effect of N6-(delta2-isopentenyl)adenosine treatment in vivo on hexokinase activity of mouse L 1210 cells.
    Journal of medicine, 1975, Volume: 6, Issue:2

    Topics: Adenosine; Adenosine Triphosphate; Animals; Cells, Cultured; Glucose; Hexokinase; Hot Temperature; Isoenzymes; Isopentenyladenosine; Kinetics; Leukemia L1210; Mice; Mice, Inbred DBA; Protein Conformation; Protein Denaturation

1975
Synthesis and biological activities of some N6-(nitro- and -aminobenzyl)adenosines.
    Journal of medicinal chemistry, 1975, Volume: 18, Issue:8

    Topics: Adenosine; Adenosine Deaminase Inhibitors; Animals; Benzyl Compounds; Benzylamines; Cattle; Cell Division; Cells, Cultured; Humans; Intestinal Mucosa; Leukemia L1210; Leukemia, Myeloid, Acute; Mice; Nitro Compounds

1975
L1210/B23.1 cells express equilibrative, inhibitor-sensitive nucleoside transport activity and lack two parental nucleoside transport activities.
    The Journal of biological chemistry, 1992, Aug-25, Volume: 267, Issue:24

    Topics: Adenine; Adenosine; Animals; Antiviral Agents; Biological Transport; Carrier Proteins; Cell Membrane; Clone Cells; Formycins; Kinetics; Leukemia L1210; Membrane Proteins; Mice; Mutagenesis; Nucleoside Transport Proteins; Nucleosides; Thioinosine; Thymidine; Tumor Cells, Cultured; Vidarabine

1992
Substrate specificity, kinetics, and stoichiometry of sodium-dependent adenosine transport in L1210/AM mouse leukemia cells.
    The Journal of biological chemistry, 1991, Apr-05, Volume: 266, Issue:10

    Topics: 4-Chloromercuribenzenesulfonate; Adenosine; Animals; Biological Transport; Ethylmaleimide; Kinetics; Leukemia L1210; Mice; Showdomycin; Sodium; Substrate Specificity; Temperature; Tumor Cells, Cultured; Vidarabine

1991
Targeting 5'-deoxy-5'-(methylthio)adenosine phosphorylase by 5'-haloalkyl analogues of 5'-deoxy-5'-(methylthio)adenosine.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:8

    Topics: Adenosine; Adenosylhomocysteinase; Animals; Antineoplastic Agents; Cell Division; Chemical Phenomena; Chemistry; Deoxyadenosines; Drug Stability; Humans; Hydrolases; Leukemia L1210; Leukemia, Experimental; Liver; Mice; Molecular Structure; Polyamines; Purine-Nucleoside Phosphorylase; Structure-Activity Relationship; Thionucleosides; Tumor Cells, Cultured

1991
Sodium-dependent nucleoside transport in mouse leukemia L1210 cells.
    The Journal of biological chemistry, 1991, Apr-05, Volume: 266, Issue:10

    Topics: Adenosine; Animals; Biological Transport; Formycins; Furosemide; Leukemia L1210; Mice; Nucleosides; Nystatin; Sodium; Thioinosine; Tumor Cells, Cultured

1991
Combined modulation of S-adenosylmethionine biosynthesis and S-adenosylhomocysteine metabolism enhances inhibition of nucleic acid methylation and L1210 cell growth.
    Cancer research, 1990, Jul-01, Volume: 50, Issue:13

    Topics: Adenosine; Animals; Cell Division; DNA, Neoplasm; Homocysteine; Leukemia L1210; Methylation; Polyamines; RNA, Neoplasm; S-Adenosylhomocysteine; S-Adenosylmethionine; Time Factors

1990
Effects of cytosine arabinoside and hydroxyurea on the synthesis of deoxyribonucleotides and DNA replication in L1210 cells.
    Advances in enzyme regulation, 1990, Volume: 30

    Topics: Adenosine; Animals; Cytarabine; Cytidine; Deoxyribonucleotides; DNA Replication; Hydroxyurea; Leukemia L1210; Mice; RNA, Neoplasm; Tumor Cells, Cultured

1990
Antitumor activity of derivatives of neplanocin A in vivo and in vitro.
    Journal of pharmacobio-dynamics, 1986, Volume: 9, Issue:2

    Topics: Adenosine; Animals; Antibiotics, Antineoplastic; Cells, Cultured; Female; Leucine; Leukemia L1210; Male; Mice; Neoplasms, Experimental; RNA; Sarcoma 180; Uridine

1986
A simple method for predicting modes of actions of antitumor agents.
    Journal of pharmacobio-dynamics, 1988, Volume: 11, Issue:4

    Topics: Adenosine; Animals; Antineoplastic Agents; DNA Replication; Guanosine; Leukemia L1210; Mitosis; Nucleosides; Protein Synthesis Inhibitors; RNA; Thymidine; Tumor Cells, Cultured; Uridine

1988
Potentiation of cytotoxicity and antitumor activity of adenosine analogs by the adenosine deaminase inhibitor adecypenol.
    The Journal of antibiotics, 1989, Volume: 42, Issue:11

    Topics: Adenosine; Adenosine Deaminase Inhibitors; Animals; Antineoplastic Agents; Cyclopentanes; Deoxyadenosines; Drug Synergism; HeLa Cells; Humans; Leukemia L1210; Mice; Molecular Structure; Nucleoside Deaminases; Purines; Vidarabine

1989
Enantiomeric selectivity of adenosine transport systems in mouse erythrocytes and L1210 cells.
    The Biochemical journal, 1989, Nov-01, Volume: 263, Issue:3

    Topics: Adenosine; Animals; Biological Transport; Erythrocyte Membrane; In Vitro Techniques; Kinetics; Leukemia L1210; Mice; Sodium; Stereoisomerism; Thioinosine

1989
Effect of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase, on polyamine metabolism in mammalian cells.
    Biochemistry, 1989, Oct-17, Volume: 28, Issue:21

    Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Cell Division; Cell Line, Transformed; Deoxyadenosines; Dose-Response Relationship, Drug; Fibroblasts; Leukemia L1210; Mice; Polyamines; S-Adenosylmethionine; Spermine Synthase; Thionucleosides; Transferases; Tumor Cells, Cultured

1989
New fluorinated carbocyclic nucleosides: synthesis and bioactivity.
    Nucleic acids symposium series, 1989, Issue:21

    Topics: Adenosine; Animals; Antineoplastic Agents; Leukemia L1210; Mice; Tumor Cells, Cultured

1989
Syntheses and antitumor activities of N6,N6-dimethyladenosine carboxylate analogues.
    Chemical & pharmaceutical bulletin, 1989, Volume: 37, Issue:10

    Topics: Adenosine; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Division; Chemical Phenomena; Chemistry; Leukemia L1210; Mice; Mice, Inbred ICR; Tumor Cells, Cultured

1989
Metabolic activation of 2,6-diaminopurine and 2,6-diaminopurine-2'-deoxyriboside to antitumor agents.
    Advances in enzyme regulation, 1989, Volume: 28

    Topics: Adenosine; Animals; Antineoplastic Agents; Biotransformation; Cell Aggregation; Cell Cycle; Cell Division; Chromatography, High Pressure Liquid; Deoxyadenosines; Kinetics; Leukemia L1210; Mice; Ribonucleotides

1989
Some pharmacological activities of novel adenine-related compounds isolated from a marine sponge Agelas mauritiana.
    Canadian journal of physiology and pharmacology, 1989, Volume: 67, Issue:4

    Topics: Adenine; Adenosine; Animals; Aorta; Cell Cycle; Erythrocytes; In Vitro Techniques; Kinetics; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Mice; Muscle Relaxation; Muscle, Smooth, Vascular; Naphthols; Porifera; Rabbits; Rats; Rats, Inbred Strains; Receptors, Purinergic

1989
Antiproliferative effects of 4',5'-unsaturated adenine nucleosides on leukemia L1210 cells in vitro.
    Experientia, 1989, Aug-15, Volume: 45, Issue:8

    Topics: Adenine Nucleotides; Adenosine; Animals; Antineoplastic Agents; Cell Division; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Cytosine Nucleotides; Guanine Nucleotides; Leukemia L1210; Tumor Cells, Cultured; Uracil Nucleotides

1989
Inhibition of human leukaemic thymidylate kinase and L1210 ribonucleotide reductase by dinucleotides of adenosine and thymidine and their phosphonate analogues.
    Biochemical pharmacology, 1988, Feb-15, Volume: 37, Issue:4

    Topics: Adenosine; Animals; Dose-Response Relationship, Drug; Humans; Kinetics; Leukemia L1210; Leukemia, Myeloid, Acute; Nucleoside-Phosphate Kinase; Oligonucleotides; Organophosphonates; Phosphotransferases; Ribonucleoside Diphosphate Reductase; Ribonucleotide Reductases; Thymidine

1988
Metabolism and metabolic effects of 2-azahypoxanthine and 2-azaadenosine.
    Biochemical pharmacology, 1985, Apr-15, Volume: 34, Issue:8

    Topics: Adenosine; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line; Chromatography, High Pressure Liquid; Deoxyribonucleotides; Humans; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; IMP Dehydrogenase; Laryngeal Neoplasms; Leukemia L1210; Macromolecular Substances; Mice; Polynucleotides; Ribonucleotides

1985
The effects on 4-aminoantifolates on 5-formyltetrahydrofolate metabolism in L1210 cells. A biochemical basis of the selectivity of leucovorin rescue.
    The Journal of biological chemistry, 1987, Jan-15, Volume: 262, Issue:2

    Topics: Adenosine; Animals; Cell Division; Floxuridine; Folic Acid; Kinetics; Leucovorin; Leukemia L1210; Mice; Thymidine

1987
Inhibition of utilization of hypoxanthine and guanine in cells treated with the carbocyclic analog of adenosine. Phosphates of carbocyclic nucleoside analogs as inhibitors of hypoxanthine (guanine) phosphoribosyltransferase.
    Molecular pharmacology, 1985, Volume: 27, Issue:6

    Topics: Adenosine; Animals; Carcinoma, Squamous Cell; Cell Line; Coformycin; Colonic Neoplasms; Cyclic GMP; Cyclic IMP; Guanine; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Inosine Nucleotides; Kinetics; Leukemia L1210; Mice; Pentosyltransferases; Ribonucleotides

1985
Properties of L1210 cells resistant to alpha-difluoromethylornithine.
    Cancer research, 1988, May-15, Volume: 48, Issue:10

    Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Deoxyadenosines; Drug Resistance; Eflornithine; Leukemia L1210; Ornithine Decarboxylase; Polyamines; Putrescine; RNA, Messenger; Thionucleosides; Tumor Cells, Cultured

1988
Effect of inhibitors of S-adenosylmethionine decarboxylase on the contents of ornithine decarboxylase and S-adenosylmethionine decarboxylase in L1210 cells.
    The Biochemical journal, 1988, Aug-15, Volume: 254, Issue:1

    Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Deoxyadenosines; Leukemia L1210; Ornithine Decarboxylase; Polyamines; Proteins; RNA, Messenger; Spermidine; Spermine; Tumor Cells, Cultured

1988
Effect of inhibitors of S-adenosylmethionine decarboxylase on polyamine content and growth of L1210 cells.
    Biochemistry, 1988, Mar-08, Volume: 27, Issue:5

    Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cell Division; Cells, Cultured; Deoxyadenosines; Enzyme Inhibitors; Kinetics; Leukemia L1210; Male; Mice; Polyamines; Prostate; Rats; Structure-Activity Relationship

1988
Preparation and antileukemic screening of some new 6'-deoxyhexopyranosyladenine nucleosides.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:8

    Topics: Adenosine; Animals; Chemical Phenomena; Chemistry; Deoxyribonucleosides; Leukemia L1210; Mice; Molecular Conformation; Structure-Activity Relationship

1987
Differences in the metabolism and metabolic effects of the carbocyclic adenosine analogs, neplanocin A and aristeromycin.
    Molecular pharmacology, 1986, Volume: 29, Issue:4

    Topics: Adenosine; Adenosine Deaminase; Adenosine Triphosphate; AMP Deaminase; Animals; Cell Division; Cell Line; Guanine; Guanosine Triphosphate; Hypoxanthine; Hypoxanthines; Isomerism; Kinetics; Leukemia L1210; Mice

1986
Synthesis and biological properties of 9-(trans-4-hydroxy-2-buten-1-yl)adenine and guanine: open-chain analogues of neplanocin A.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:2

    Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Antibiotics, Antineoplastic; Guanine; Indicators and Reagents; Leukemia L1210; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Spectrophotometry, Ultraviolet; Structure-Activity Relationship

1987
Studies on compounds related to antitumor agents. Synthesis of 8-substituted N6,N6-dimethyladenosine derivatives.
    Chemical & pharmaceutical bulletin, 1986, Volume: 34, Issue:9

    Topics: Adenosine; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Chemical Phenomena; Chemistry; Leukemia L1210; Mice

1986
Effects of nucleoside transport inhibitors on the salvage and toxicity of adenosine and deoxyadenosine in L1210 and P388 mouse leukemia cells.
    Cancer research, 1985, Volume: 45, Issue:12 Pt 1

    Topics: Adenosine; Animals; Biological Transport; Coformycin; Deoxyadenosines; Dipyridamole; Inosine; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Mice; Pentostatin; Thioinosine

1985
5'-Deoxy-5'-methylthioadenosine phosphorylase--III. Role of the enzyme in the metabolism and action of 5'-halogenated adenosine analogs.
    Biochemical pharmacology, 1985, Feb-01, Volume: 34, Issue:3

    Topics: Adenine Nucleotides; Adenosine; Animals; Antineoplastic Agents; Biotransformation; Cell Line; Deoxyadenosines; Humans; Kinetics; Leukemia L1210; Leukemia L5178; Leukemia, Experimental; Mice; Pentosyltransferases; Purine-Nucleoside Phosphorylase

1985
Biochemical mode of cytotoxic action of neplanocin A in L1210 leukemic cells.
    Cancer research, 1986, Volume: 46, Issue:3

    Topics: Adenosine; Adenosine Kinase; Animals; Biotransformation; Cell Survival; DNA, Neoplasm; Drug Resistance; Kinetics; Leukemia L1210; Leukemia P388; Mice; RNA, Neoplasm

1986
Synthesis and biological activity of a novel adenosine analogue, 3-beta-D-ribofuranosylthieno[2,3-d]pyrimidin-4-one.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:4

    Topics: Adenosine; Adenosine Kinase; Animals; Antineoplastic Agents; Biotransformation; In Vitro Techniques; Leukemia L1210; Mice; Pyrimidine Nucleosides

1985
Analogs of 5'-deoxy-5'-(methylthio)adenosine.
    Journal of medicinal chemistry, 1974, Volume: 17, Issue:11

    Topics: Adenosine; Animals; Antineoplastic Agents; Carcinoma; Carcinoma, Squamous Cell; Cell Line; Humans; Laryngeal Neoplasms; Leukemia L1210; Mice; Mouth Neoplasms; Structure-Activity Relationship; Sulfides

1974
N 6 -Substituted adenosines: synthesis, biological activity, and some structure-activity relationships.
    Journal of medicinal chemistry, 1972, Volume: 15, Issue:2

    Topics: Adenocarcinoma; Adenosine; Animals; Antineoplastic Agents; Cells, Cultured; Chromatography, Paper; Escherichia coli; Female; Leukemia L1210; Mammary Neoplasms, Experimental; Mice; Nicotiana; Optical Rotation; Plants, Toxic; Sarcoma 180; Spectrum Analysis; Structure-Activity Relationship; Ultraviolet Rays

1972
Synthesis and biological activity of selected 2,6-disubstituted-(2-deoxy- -and- -D-erythro-pentofuranosyl)purines.
    Journal of medicinal chemistry, 1972, Volume: 15, Issue:7

    Topics: Adenosine; Animals; Cells, Cultured; Deoxyadenosines; Depression, Chemical; Enterococcus faecalis; Escherichia coli; Leukemia L1210; Magnetic Resonance Spectroscopy; Nucleosides; Optical Rotation; Purine Nucleotides; Purines; Spectrum Analysis; Stereoisomerism; Structure-Activity Relationship; Ultraviolet Rays

1972
Effects of persantin on several transport systems of murine leukemias.
    Biochimica et biophysica acta, 1972, Oct-23, Volume: 288, Issue:1

    Topics: Adenine; Adenosine; Amino Acids; Animals; Biological Transport; Cell Line; Cyclopentanes; Cytidine; Depression, Chemical; Dipyridamole; Fucose; Glucose; Glycerol; Leukemia L1210; Leukemia, Experimental; Mice; Phosphates; Uracil; Uridine

1972
Antitumor activity of N6-phenyladenosine, and inhibitor of adenosine utilization, in combination with related purine analogs.
    Cancer research, 1973, Volume: 33, Issue:10

    Topics: Adenosine; Animals; Benzene Derivatives; Carcinoma 256, Walker; Cell Division; Cells, Cultured; Drug Synergism; Evaluation Studies as Topic; Leukemia L1210; Mercaptopurine; Mice; Mice, Inbred DBA; Rats; Sarcoma 180; Thioguanine

1973
Stimulation of ornithine decarboxylase activity and inhibition of S-adenosyl-L-methionine decarboxylase activity in leukaemic mice by methylglyoxal bis(guanylhydrazone).
    The Biochemical journal, 1973, Volume: 136, Issue:4

    Topics: Adenosine; Amidines; Animals; Carboxy-Lyases; Depression, Chemical; Glyoxal; Hydrazones; Leukemia L1210; Male; Methionine; Mice; Ornithine; Polyamines; S-Adenosylmethionine; Spermidine; Stimulation, Chemical

1973
Inhibition of protein synthesis by 5'-sulfamoyladenosine.
    Biochemistry, 1971, Nov-23, Volume: 10, Issue:24

    Topics: Adenine Nucleotides; Adenosine; Aminohydrolases; Animals; Bacterial Proteins; Carbon Isotopes; Cells, Cultured; Deoxyadenosines; DNA, Bacterial; Escherichia coli; Inosine; Intestinal Mucosa; Leukemia L1210; Lysine; Mice; Muscles; Nucleosides; Phenylalanine; Proline; Rabbits; Rats; RNA, Bacterial; RNA, Transfer; Streptococcus; Structure-Activity Relationship; Sulfonamides

1971
Tissue-specific effects of N 6 -( 2 -isopentenyl) adenosine on the incorporation of precursors into nucleic acids and protein in rats and mice.
    Cancer research, 1972, Volume: 32, Issue:6

    Topics: Adenosine; Alkenes; Animals; Cell Division; DNA; Female; Intestinal Mucosa; Leukemia L1210; Liver; Mice; Mice, Inbred Strains; Nucleic Acids; Phenylalanine; Proteins; Rats; Rats, Inbred Strains; RNA; Spleen; Thymidine; Thymus Gland; Time Factors; Tritium; Uridine

1972
Deamination of arabinosyladenine by adenosine deaminase and inhibition by arabinosyl-6-mercaptopurine.
    Cancer research, 1972, Volume: 32, Issue:8

    Topics: Adenine; Adenosine; Aminohydrolases; Animals; Antibiotics, Antineoplastic; Arabinose; Cell Fractionation; Cell Line; Deamination; Drug Resistance; Female; Leukemia L1210; Mercaptopurine; Mice; Mice, Inbred Strains; Mutation; Nucleosides

1972