Page last updated: 2024-08-24

adenosine and Intraocular Pressure

adenosine has been researched along with Intraocular Pressure in 39 studies

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's12 (30.77)18.2507
2000's15 (38.46)29.6817
2010's10 (25.64)24.3611
2020's2 (5.13)2.80

Authors

AuthorsStudies
Chen, CC; Fu, HI; Hsu, JH; Lee, LY; Tung, KC1
Aires, ID; Ambrósio, AF; Boia, R; Ferreira-Silva, J; Santiago, AR1
Ahmed, F; Albers, DS; Baumgartner, RA; Li, G; Navarro, ID; Stamer, WD; Torrejon, KY; Unser, AM1
Bar-Yehuda, S; Cohen, S; Fishman, P1
Nagaoka, T; Nakabayashi, S; Tani, T; Yoshida, A; Yoshioka, T1
Agarwal, P; Agarwal, R1
Civan, MM; Do, CW; Karl, MO; Leung, CT; Li, A; Macknight, AD; McLaughlin, CW; Stone, RA; Wang, Z; Zellhuber-McMillan, S1
Avila, MY; Besada, P; Civan, MM; Do, CW; Gao, ZG; Jacobson, KA; Jeong, LS; Joshi, B; Peterson-Yantorno, K; Stone, RA; Wang, Z1
Avni, I; Bakshi, E; Barequet, IS; Bristol, DR; Chetrit, N; Cohn, I; Farbstein, M; Fishman, P; Fishman, S; Garzozi, HJ; Harpaz, Z; Jacobson, KA; Kerns, WD; Litvin, G; Sartani, G; Segev, F; Silverman, MH; Tomkins, O; Varssano, D; Yehuda, SB; Zadok, D1
Civan, MM; Leung, CT; Li, A; Mitchell, CH; Peterson-Yantorno, K; Stamer, WD1
Dorner, GT; Garhofer, G; Kolodjaschna, J; Resch, H; Schmetterer, L; Schmidl, D; Weigert, G; Wolzt, M1
Epstein, DL; Gonzalez, P; Li, G; Luna, C; Spasojevic, I; Wu, J1
Huang, WC; Luo, X; Yang, Z; Zhong, Y1
Avila, MY; Civan, MM; Stone, RA2
Crosson, CE; Daines, BS; Kent, AR; McAleer, MS1
Ehrlich, P; Fuchsjäger-Mayrl, G; Luksch, A; Polska, E; Schmetterer, L1
Endo, K; Hosokawa, T; Kogi, K; Konno, T; Nagai, A; Nakahata, N; Ohnuma, SY; Uchibori, T; Uemoto, K1
Konno, T1
Kogi, K; Konno, T; Murakami, A; Nagai, A; Nakahata, N; Uchibori, T1
Kogi, K; Konno, T; Nagai, A; Nakahata, N; Uchibori, T2
Avila, MY; Civan, MM; Coca-Prados, M; Jacobson, KA; Peterson-Yantorno, K; Stone, RA; Yang, H1
Kogi, K; Konno, T; Nagai, A; Nakahata, N; Sato, A; Uchibori, T1
Avila, MY; Civan, MM; Do, CW; Jacobson, KA; Stone, RA; Wang, Z1
Crosson, CE2
Crosson, CE; Gray, T2
Sugrue, MF1
Crosson, CE; Gabelt, BT; Kaufman, PL; Tian, B1
Caicedo, M; Cepelík, J; Dedina, M; Hynie, S1
Crosson, CE; Petrovich, M1
Crosson, CE; Niazi, Z1
Hennes, HJ; Jantzen, JP; Rochels, R; Wallenfang, T1
Araie, M; Kiuchi, Y; Mishima, HK1
Kiuchi, Y; Mishima, HK; Yamazaki, M; Yasumoto, T; Yokoyama, T1
Fukami, S; Iijima, Y; Kaneko, M; Kiuchi, Y; Mishima, H; Yamazaki, M; Yasumoto, T; Yokoyama, T1
Kiuchi, Y1

Reviews

5 review(s) available for adenosine and Intraocular Pressure

ArticleYear
Targeting the A3 adenosine receptor for glaucoma treatment (review).
    Molecular medicine reports, 2013, Volume: 7, Issue:6

    Topics: Adenosine; Adenosine A3 Receptor Agonists; Anti-Inflammatory Agents; Apoptosis; Dry Eye Syndromes; Glaucoma; Humans; Intraocular Pressure; Receptor, Adenosine A3; Retinal Ganglion Cells

2013
Newer targets for modulation of intraocular pressure: focus on adenosine receptor signaling pathways.
    Expert opinion on therapeutic targets, 2014, Volume: 18, Issue:5

    Topics: Adenosine; Aqueous Humor; Ciliary Body; Drug Design; Gene Expression Regulation; Glaucoma; GTP-Binding Proteins; Humans; Intracellular Signaling Peptides and Proteins; Intraocular Pressure; Models, Molecular; Molecular Targeted Therapy; Protein Conformation; Protein Kinases; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Signal Transduction; Trabecular Meshwork

2014
Adenosine, adenosine receptors and glaucoma: an updated overview.
    Biochimica et biophysica acta, 2013, Volume: 1830, Issue:4

    Topics: Adenosine; Animals; Aqueous Humor; Glaucoma; Humans; Intraocular Pressure; Receptors, Purinergic P1

2013
[Role of adenosine in intraocular pressure].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2004, Volume: 123, Issue:4

    Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Drug Design; Glaucoma; Humans; Intraocular Pressure; Ocular Hypertension; Phenethylamines; Rabbits; Receptors, Adenosine A2

2004
New approaches to antiglaucoma therapy.
    Journal of medicinal chemistry, 1997, Aug-29, Volume: 40, Issue:18

    Topics: Adenosine; Animals; Antihypertensive Agents; Cannabinoids; Drug Design; Endothelins; Glaucoma; Guanylate Cyclase; Humans; Intraocular Pressure; Neuroprotective Agents

1997

Trials

3 trial(s) available for adenosine and Intraocular Pressure

ArticleYear
Treatment of dry eye syndrome with orally administered CF101: data from a phase 2 clinical trial.
    Ophthalmology, 2010, Volume: 117, Issue:7

    Topics: Adenosine; Adenosine A3 Receptor Agonists; Administration, Oral; Cornea; Double-Blind Method; Dry Eye Syndromes; Electrocardiography; Female; Fluorophotometry; Humans; Intraocular Pressure; Male; Middle Aged; Tears; Treatment Outcome

2010
Role of adenosine in the control of choroidal blood flow during changes in ocular perfusion pressure.
    Investigative ophthalmology & visual science, 2011, Jul-29, Volume: 52, Issue:8

    Topics: Adenosine; Adult; Choroid; Cross-Over Studies; Homeostasis; Humans; Injections, Intravenous; Intraocular Pressure; Male; Placebos; Regional Blood Flow; Suction; Vascular Resistance; Vasodilator Agents; Young Adult

2011
Effects of adenosine on intraocular pressure, optic nerve head blood flow, and choroidal blood flow in healthy humans.
    Investigative ophthalmology & visual science, 2003, Volume: 44, Issue:7

    Topics: Adenosine; Adult; Blood Flow Velocity; Choroid; Cross-Over Studies; Double-Blind Method; Humans; Interferometry; Intraocular Pressure; Laser-Doppler Flowmetry; Lasers; Male; Optic Disk; Regional Blood Flow; Vasodilation; Vasodilator Agents

2003

Other Studies

31 other study(ies) available for adenosine and Intraocular Pressure

ArticleYear
Lowering the Intraocular Pressure in Rats and Rabbits by
    Molecules (Basel, Switzerland), 2022, Jan-21, Volume: 27, Issue:3

    Topics: Adenosine; Animals; Apoptosis; Cordyceps; Disease Models, Animal; Glaucoma; Intraocular Pressure; Male; Mycelium; Rabbits; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells

2022
Activation of Adenosine A
    International journal of molecular sciences, 2020, Sep-30, Volume: 21, Issue:19

    Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Cell Death; Cell Movement; Cell Proliferation; Glaucoma; Humans; Intraocular Pressure; Microglia; Optic Nerve; Optic Nerve Injuries; Phagocytosis; Rats; Receptor, Adenosine A3; Retinal Degeneration; Retinal Ganglion Cells

2020
Trabodenoson, an Adenosine Mimetic With A1 Receptor Selectivity Lowers Intraocular Pressure by Increasing Conventional Outflow Facility in Mice.
    Investigative ophthalmology & visual science, 2018, 01-01, Volume: 59, Issue:1

    Topics: Adenosine; Administration, Ophthalmic; Animals; Antihypertensive Agents; Aqueous Humor; Biomimetics; Blotting, Western; Cell Line; Collagen Type IV; Fibronectins; Humans; Immunohistochemistry; Intraocular Pressure; Luminescent Measurements; Matrix Metalloproteinase 14; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Nitrates; Purines; Receptor, Adenosine A1; Tissue Scaffolds; Tonometry, Ocular; Trabecular Meshwork

2018
Autoregulation of retinal blood flow in response to decreased ocular perfusion pressure in cats: comparison of the effects of increased intraocular pressure and systemic hypotension.
    Investigative ophthalmology & visual science, 2014, Jan-20, Volume: 55, Issue:1

    Topics: Adenosine; Animals; Cats; Disease Models, Animal; Endothelium-Dependent Relaxing Factors; Excitatory Amino Acid Agonists; Female; Homeostasis; Hypotension; Intraocular Pressure; Intravitreal Injections; Laser-Doppler Flowmetry; Male; N-Methylaspartate; Nitric Oxide; Ocular Hypertension; Regional Blood Flow; Retina; Vasodilator Agents

2014
Electron probe X-ray microanalysis of intact pathway for human aqueous humor outflow.
    American journal of physiology. Cell physiology, 2008, Volume: 295, Issue:5

    Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Aqueous Humor; Cell Size; Chlorides; Electron Probe Microanalysis; Enzyme Inhibitors; Feasibility Studies; Humans; Hypotonic Solutions; Intraocular Pressure; Norbornanes; Osmotic Pressure; Ouabain; Phenethylamines; Phosphorus; Potassium; Receptor, Adenosine A1; Receptors, Adenosine A2; Sodium; Sodium-Potassium-Exchanging ATPase; Trabecular Meshwork

2008
Nucleoside-derived antagonists to A3 adenosine receptors lower mouse intraocular pressure and act across species.
    Experimental eye research, 2010, Volume: 90, Issue:1

    Topics: Adenosine; Adenosine A3 Receptor Antagonists; Animals; Antihypertensive Agents; Cattle; Cell Size; Ciliary Body; Female; Intraocular Pressure; Male; Mice; Ocular Hypertension; Pigment Epithelium of Eye; Tonometry, Ocular

2010
Mechanisms of ATP release by human trabecular meshwork cells, the enabling step in purinergic regulation of aqueous humor outflow.
    Journal of cellular physiology, 2012, Volume: 227, Issue:1

    Topics: Adenosine; Adenosine Triphosphate; Aqueous Humor; Blotting, Western; Connexins; Glaucoma; HEK293 Cells; Humans; Intraocular Pressure; Luminescent Measurements; Microscopy, Confocal; Nerve Tissue Proteins; Real-Time Polymerase Chain Reaction; Receptors, Purinergic P2X7; Reverse Transcriptase Polymerase Chain Reaction; Trabecular Meshwork

2012
Endogenous production of extracellular adenosine by trabecular meshwork cells: potential role in outflow regulation.
    Investigative ophthalmology & visual science, 2012, Oct-01, Volume: 53, Issue:11

    Topics: 5'-Nucleotidase; Adenosine; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Antigens, CD; Apyrase; Aqueous Humor; Cells, Cultured; Cyclic AMP; Extracellular Space; Gene Expression Regulation, Enzymologic; Glaucoma; Intraocular Pressure; Membrane Microdomains; Mice; Mice, Inbred Strains; Stress, Mechanical; Swine; Trabecular Meshwork

2012
Knockout of A3 adenosine receptors reduces mouse intraocular pressure.
    Investigative ophthalmology & visual science, 2002, Volume: 43, Issue:9

    Topics: Adenosine; Administration, Topical; Animals; Dihydropyridines; Intraocular Pressure; Mice; Mice, Inbred C57BL; Mice, Knockout; Ophthalmic Solutions; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A3; Receptors, Purinergic P1

2002
Intraocular adenosine levels in normal and ocular-hypertensive patients.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2003, Volume: 19, Issue:2

    Topics: Adenosine; Aqueous Humor; Case-Control Studies; Chromatography, High Pressure Liquid; Humans; Inosine; Intraocular Pressure; Ocular Hypertension; Osmolar Concentration

2003
Effects of 2-alkynyladenosine derivatives on intraocular pressure in rabbits.
    European journal of pharmacology, 2004, Feb-23, Volume: 486, Issue:3

    Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Administration, Topical; Alkynes; Animals; Antihypertensive Agents; Chymotrypsin; Intraocular Pressure; Male; Ocular Hypertension; Rabbits; Time Factors

2004
Involvement of adenosine A2a receptor in intraocular pressure decrease induced by 2-(1-octyn-1-yl)adenosine or 2-(6-cyano-1-hexyn-1-yl)adenosine.
    Journal of pharmacological sciences, 2005, Volume: 97, Issue:4

    Topics: Adenosine; Alkynes; Animals; Aqueous Humor; Cyclic AMP; Glaucoma; Humans; Intraocular Pressure; Kinetics; Male; Rabbits; Receptor, Adenosine A2A

2005
2-(1-Hexyn-1-yl)adenosine-induced intraocular hypertension is mediated via K+ channel opening through adenosine A2A receptor in rabbits.
    European journal of pharmacology, 2005, Aug-22, Volume: 518, Issue:2-3

    Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Alkynes; Animals; Antihypertensive Agents; Caffeine; Decanoic Acids; Glyburide; Hydroxy Acids; Hypotonic Solutions; Intraocular Pressure; Male; Ocular Hypertension; Phenethylamines; Pinacidil; Potassium Channel Blockers; Potassium Channels; Rabbits; Receptor, Adenosine A2A; Sodium Chloride; Time Factors; Xanthines

2005
The cross-species A3 adenosine-receptor antagonist MRS 1292 inhibits adenosine-triggered human nonpigmented ciliary epithelial cell fluid release and reduces mouse intraocular pressure.
    Current eye research, 2005, Volume: 30, Issue:9

    Topics: Adenosine; Adenosine A3 Receptor Antagonists; Administration, Topical; Animals; Aqueous Humor; Cell Size; Cells, Cultured; Ciliary Body; Dihydropyridines; Epithelial Cells; Female; Humans; Intraocular Pressure; Male; Mice; Receptor, Adenosine A3

2005
Adenosine A2A receptor mediated protective effect of 2-(6-cyano-1-hexyn-1-yl)adenosine on retinal ischaemia/reperfusion damage in rats.
    The British journal of ophthalmology, 2006, Volume: 90, Issue:7

    Topics: Adenosine; Adenosine A2 Receptor Agonists; Administration, Topical; Animals; Antihypertensive Agents; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Intraocular Pressure; Ischemic Preconditioning; Male; Phenethylamines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Retinal Vessels

2006
Effect of 2-(6-cyano-1-hexyn-1-yl)adenosine on ocular blood flow in rabbits.
    Life sciences, 2007, Feb-27, Volume: 80, Issue:12

    Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Eye; Flavins; Intraocular Pressure; Male; Rabbits; Regional Blood Flow; Retinal Vessels; Vasodilator Agents; Xanthines

2007
Barrier qualities of the mouse eye to topically applied drugs.
    Experimental eye research, 2007, Volume: 85, Issue:1

    Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Administration, Topical; Animals; Carbachol; Cornea; Dihydropyridines; Eye; Female; Intraocular Pressure; Male; Mice; Miotics; Pupil; Sclera; Tonometry, Ocular; Vasodilator Agents

2007
Adenosine receptor activation modulates intraocular pressure in rabbits.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 273, Issue:1

    Topics: Adenosine; Animals; Cyclic AMP; Intraocular Pressure; Norepinephrine; Phenylisopropyladenosine; Purinergic P1 Receptor Agonists; Rabbits; Receptors, Purinergic P1

1995
Modulation of intraocular pressure by adenosine agonists.
    Journal of ocular pharmacology, 1994,Spring, Volume: 10, Issue:1

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cyclic AMP; Dose-Response Relationship, Drug; Intraocular Pressure; Ocular Hypotension; Ophthalmic Solutions; Rabbits; Receptors, Purinergic P1; Vasodilator Agents

1994
Characterization of ocular hypertension induced by adenosine agonists.
    Investigative ophthalmology & visual science, 1996, Volume: 37, Issue:9

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Administration, Topical; Animals; Aqueous Humor; Cats; Cornea; Eye Proteins; Intraocular Pressure; Ocular Hypertension; Phenethylamines; Phenylisopropyladenosine; Purinergic P1 Receptor Antagonists; Rabbits; Tonometry, Ocular; Vasodilator Agents

1996
Effects of adenosine agonists on intraocular pressure and aqueous humor dynamics in cynomolgus monkeys.
    Experimental eye research, 1997, Volume: 64, Issue:6

    Topics: Adenosine; Administration, Topical; Animals; Aqueous Humor; Drug Administration Schedule; Intraocular Pressure; Macaca fascicularis; Phenylisopropyladenosine; Theobromine

1997
Effects of drugs acting on adrenergic and adenosine receptors on the intraocular pressure and the activity of adenylyl cyclase in ciliary processes and their sensitivity to pertussis toxin.
    Physiological research, 1997, Volume: 46, Issue:3

    Topics: Adenosine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenergic Agonists; Adrenergic alpha-Antagonists; Animals; Ciliary Body; Clonidine; Epinephrine; Fenoterol; Intraocular Pressure; Pertussis Toxin; Purinergic P1 Receptor Agonists; Rabbits; Receptors, Adrenergic; Receptors, Purinergic P1; Virulence Factors, Bordetella; Yohimbine

1997
Contributions of adenosine receptor activation to the ocular actions of epinephrine.
    Investigative ophthalmology & visual science, 1999, Volume: 40, Issue:9

    Topics: Adenosine; Adrenergic Agonists; Animals; Aqueous Humor; Epinephrine; Inosine; Intraocular Pressure; Ophthalmic Solutions; Pupil; Purinergic P1 Receptor Antagonists; Rabbits; Receptors, Purinergic P1; Theobromine; Theophylline

1999
Ocular effects associated with the chronic administration of the adenosine A(1) agonist cyclohexyladenosine.
    Current eye research, 2000, Volume: 21, Issue:4

    Topics: Adenosine; Animals; Aqueous Humor; Drug Tolerance; Intraocular Pressure; Pupil; Purinergic P1 Receptor Agonists; Rabbits; Regression Analysis

2000
Intraocular pressure responses to the adenosine agonist cyclohexyladenosine: evidence for a dual mechanism of action.
    Investigative ophthalmology & visual science, 2001, Volume: 42, Issue:8

    Topics: Adenosine; Administration, Topical; Animals; Anterior Chamber; Aqueous Humor; Dose-Response Relationship, Drug; Fluorophotometry; Intraocular Pressure; Ocular Hypotension; Purinergic P1 Receptor Agonists; Rabbits

2001
A(1)-, A(2A)- and A(3)-subtype adenosine receptors modulate intraocular pressure in the mouse.
    British journal of pharmacology, 2001, Volume: 134, Issue:2

    Topics: Adenosine; Animals; Dihydropyridines; Dose-Response Relationship, Drug; Female; Intraocular Pressure; Male; Mice; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A2A; Receptor, Adenosine A3; Receptors, Purinergic P1; Time Factors

2001
Deliberate arterial hypotension does not reduce intraocular pressure in pigs.
    Anesthesiology, 1992, Volume: 77, Issue:3

    Topics: Adenosine; Animals; Hemodynamics; Hypotension, Controlled; Intracranial Pressure; Intraocular Pressure; Isoflurane; Nitroprusside; Pulmonary Gas Exchange; Swine

1992
Effects of a cyclic AMP phosphodiesterase inhibitor, 8'-pivaloyloxymethyl ester of griseolic acid, on aqueous humor dynamics in rabbits.
    Japanese journal of ophthalmology, 1991, Volume: 35, Issue:1

    Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Adenosine; Administration, Topical; Animals; Aqueous Humor; Biological Transport, Active; Blood; Eye Proteins; Fluorophotometry; Intraocular Pressure; Male; Rabbits; Tonometry, Ocular

1991
A cyclic AMP phosphodiesterase inhibitor, 8'-pivaloyloxymethyl ester (POM-ester) of griseolic acid, lowers rabbit intraocular pressure.
    Current eye research, 1991, Volume: 10, Issue:9

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Animals; Ciliary Body; Cornea; Cyclic GMP; Intraocular Pressure; Iris; Male; Permeability; Rabbits; Vitreous Body

1991
Griseolic acid, a cAMP phosphodiesterase inhibitor, and its ester: increase in cellular cAMP levels and reduction of intraocular pressure.
    Advances in second messenger and phosphoprotein research, 1990, Volume: 24

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Animals; Cattle; Cell Line; Cyclic AMP; Esters; Fibroblasts; Intraocular Pressure; Mice; Molecular Structure; Rabbits; Structure-Activity Relationship

1990
[Changes in ocular hypotensive effect of griseolic acid with isoproterenol, timolol and melanin].
    Nippon Ganka Gakkai zasshi, 1990, Volume: 94, Issue:7

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Animals; Depression, Chemical; Drug Synergism; Female; Intraocular Pressure; Isoproterenol; Male; Melanins; Rabbits; Timolol

1990