Page last updated: 2024-08-24

adenosine and Epilepsy

adenosine has been researched along with Epilepsy in 115 studies

Research

Studies (115)

TimeframeStudies, this research(%)All Research%
pre-199012 (10.43)18.7374
1990's24 (20.87)18.2507
2000's33 (28.70)29.6817
2010's30 (26.09)24.3611
2020's16 (13.91)2.80

Authors

AuthorsStudies
Guo, M; Li, T1
Chen, L; Chen, Y; Jiao, K; Law, WJ; McMahon, L; Pati, S; Pizarro, D; Saggu, S; Wang, Q1
Faingold, CL; Feng, HJ1
Bertoncello, KT; Bonan, CD1
Alves, M; Boison, D; Purnell, BS1
Cui, Y; Li, X; Lin, Y; Ma, W; Qiu, W; Wang, Q; Wang, Y; Wei, F; Xiong, H; Xu, R; Zhu, J1
Boison, D; Daniels, SD1
Boison, D; Rho, JM1
Li, T; Wang, X1
Chen, F; Liu, H; Luo, L; Ma, H; Qu, X; Xu, H; Yang, L; Zhang, R; Zhu, H1
Costa Cruz, PH; Kawahara, Y1
Becker, PH; Benoist, JF; Davit-Spraul, A; Demir, Z; Gaignard, P; Gonzales, E; Habes, D; Imbard, A; Jacquemin, E; Mozer Glassberg, Y; Mussini, C; Rozenfeld Bar Lev, M; Sevin, C; Slama, A; Thérond, P1
Okada, S; Sakurai, M; Yang, Y1
Alves, M; Beamer, E; Conte, G; Dale, N; de Diego-Garcia, L; Delanty, N; El-Naggar, H; Engel, T; Henshall, DC; Khalil, M; Lacey, A; Rosenow, F; Tian, F1
Binder, DK; Steinhäuser, C1
Beamer, E; Boison, D; Engel, T; Kuchukulla, M1
Gou, Y; Luo, L; Shan, P; Zhang, J; Zhu, S1
Huang, H; Li, D; Luo, Z; Peng, Y; Qiu, X; Wang, J; Xu, P; Xu, Z; Zhang, J1
da Silva, RS; Machado Torresini, F; Menezes, FP; Nery, LR1
Adamec, J; Grove, R; Madhavan, D; Roundtree, HM; Samson, KK; Simeone, KA; Simeone, TA; Smith, DD; Warren, TJ1
Frenguelli, BG; Hall, J1
Boison, D; Reemmer, J; Weltha, L1
Hendricks, WD; Schnell, E; Westbrook, GL1
Kowalski, A; Kuśmirowska, K; Rebas, E1
Boison, D; Farrell, JM; Kaplan, DL; Lusardi, TA; Lytle, NK; Pritchard, EM; Sandau, US; Williams-Karnesky, RL1
Bae, N; Booher, ME; Cox, T; Gabriel, GJ; He, C; Iacoban, P; Olsen, MJ; Rowles, J; Tribbey, L; Wang, GZ; Zheng, G; Zhou, L1
Kotowski, J; Świąder, MJ; Łuszczki, JJ1
Boison, D10
Faingold, CL; Kommajosyula, SP; Randall, ME1
Boison, D; Faingold, CL; Richerson, GB; Ryvlin, P1
Abunassar, J; Chong, AY; Hibbert, B; Le May, MR; Malhotra, N; Pourdjabbar, A; So, DY; Whitten, TA1
Cieślak, M; Komoszyński, M; Wojtczak, A1
Boison, D; Kaplan, DL; Lan, JQ; Li, T; Pritchard, EM; Wilz, A1
Matar, KM1
Bonan, CD; Morsch, VM; Schetinger, MR; Wyse, AT1
Arcella, A; Cantore, G; Di Gennaro, G; Esposito, V; Eusebi, F; Fredholm, BB; Fucile, S; Limatola, C; Manfredi, M; Martinello, K; Mascia, A; Miledi, R; Piccari, V; Quarato, PP; Roseti, C; Simonato, M1
Alptekin, M; Erkutlu, I; Kurtul, N; Pençe, S; Tan, U1
Boison, D; Kaplan, DL; Li, T; Lusardi, TA; Pritchard, EM; Szybala, C; Wilz, A1
Costentin, J; El Yacoubi, M; Ledent, C; Parmentier, M; Vaugeois, JM1
Boison, D; Li, T; Shen, HY1
Boison, D; Stewart, KA1
McCown, TJ1
Fathollahi, Y; Mirnajafizadeh, J; Salmani, ME; Semnanian, S1
Boison, D; Boon, P; Raedt, R; Theofilas, P; Van Dycke, A; Verstraete, A; Vonck, K; Wadman, W1
Burnstock, G; Fredholm, BB; Verkhratsky, A1
Boon, P; Raedt, R; Van Dycke, A; Vonck, K1
Ankarali, S; Ayyildiz, M; Marangoz, AH; Marangoz, C; Yildirim, M1
Kostopoulos, G; Moschovos, C; Papatheodoropoulos, C1
Olsen, M; Powers, R; Rowles, J; Wong, M1
Li, TF; Luan, GM1
Binder, DK; Fiacco, TA; Hsu, MS; Hubbard, JA1
Aebischer, P; Boison, D; Déglon, N; Huber, A; Möhler, H; Padrun, V1
Almasi, M; Fathollahi, Y; Firoozabadi, P; Mohammad, S; Omrani, A; Semnanian, S1
Amaral, O; Battastini, AM; Bonan, CD; Bruno, AN; Coitinho, A; Oses, JP; Sarkis, JJ1
Bernays, R; Blau, N; Boison, D; Imhof, HG; Rudolph, U; Wieser, HG; Yonekawa, Y1
Namiki, A; Ohmori, H; Sato, Y1
Dobelis, P; Dulla, CG; Frenguelli, BG; Masino, SA; Pearson, T; Staley, KJ1
Boison, D; Fedele, DE; Kaplan, DL; Meinel, L; Merkle, HP; Schumacher, C; Uebersax, L1
Asimakopoulos, B; Efthimiadou, A; Nikolettos, NK; Pagonopoulou, O1
Marangoz, C; Yildirim, M1
Ahmadi, B; Akhondzadeh, S; Motamedi, M; Razeghi, S; Togha, M1
Boison, D; Brüstle, O; Koch, P; Lan, JQ; Li, T; Lusardi, T; Segschneider, M; Simon, RP; Steinbeck, JA; Wilz, A1
Lewin, E1
Porta, R; Schatz, RA; Sellinger, OZ; Wilens, TE1
Foster, AC; Miller, LP; Wiesner, JB1
Beani, L; Bianchi, C; Borea, PA; Muzzolini, A; Simonato, M; Varani, K1
Bingmann, D; Moraidis, I1
Hosseinzadeh, H; Stone, TW1
Hattori, Y; Hayashi, Y; Hori, Y; Islam, N; Moriwaki, A1
Hattori, Y; Hayashi, Y; Hori, Y; Moriwaki, A1
Berman, RF; Janusz, CA1
Fochtmann, L; Francis, A1
Brodie, MJ; Ross, FM; Stone, TW1
Brown, JK; O'Regan, ME1
Bosschaart, AN; Duran, M; Hageman, G; Tien Poll-The, B; van den Bergh, FA1
Chesi, AJ; Stone, TW1
Dale, TJ; Dupere, JR; Starkey, SJ; Xie, X1
Giraldez, L; Girardi, E1
Borowicz, KK; Czuczwar, SJ; Kleinrok, Z1
Stringer, JL; Xiong, ZQ1
Blondeau, N; Heurteaux, C; Lazdunski, M; Plamondon, H; Richelme, C1
Haas, HL; Selbach, O1
Ates, N; Ilbay, G; Karson, A; Sahin, D1
Georgiev, V; Kambourova, T; Tchekalarova, J1
He, RR; Wang, H; Wang, ZA1
Hattori, Y; Hayashi, Y; Hori, Y; Lu, YF; Moriwaki, A1
Birnstiel, S; Gerber, U; Greene, RW1
Schubert, P1
Gale, K; Miller, LP; Murray, TF; Zhong, P1
During, MJ; Spencer, DD1
Greene, RW; Haas, HL1
Dragunow, M2
Czuczwar, SJ; Janusz, W; Kleinrok, Z; Szczepanik, B1
Angelatou, F; Kostopoulos, G; Pagonopoulou, O1
Bartrup, JT; Connick, JH; Stone, TW1
Hattori, Y1
Avoli, M; Drapeau, C; Kostopoulos, G; Olivier, A; Villemeure, JG1
Chin, JH1
Ault, B; Wang, CM1
Caporali, MG; Niglio, T; Popoli, P; Scotti de Carolis, A1
O'Brien, DR1
Benedetti, M; Frank, C; Sagratella, S; Scotti de Carolis, A1
Dóra, E; Kovách, AG1
Chesielski, L; Kempf, E; Lehmann, A; Maitre, M; Mandel, P1
Hankiewicz, J; Lesniak, M1

Reviews

38 review(s) available for adenosine and Epilepsy

ArticleYear
Adenosine Dysfunction in Epilepsy and Associated Comorbidities.
    Current drug targets, 2022, Volume: 23, Issue:4

    Topics: Adenosine; Adenosine Kinase; Anticonvulsants; Epilepsy; Humans; Seizures

2022
A unified hypothesis of SUDEP: Seizure-induced respiratory depression induced by adenosine may lead to SUDEP but can be prevented by autoresuscitation and other restorative respiratory response mechanisms mediated by the action of serotonin on the periaqu
    Epilepsia, 2023, Volume: 64, Issue:4

    Topics: Adenosine; Animals; Death, Sudden; Epilepsy; Humans; Periaqueductal Gray; Respiratory Insufficiency; Return of Spontaneous Circulation; Seizures; Serotonin; Sudden Unexpected Death in Epilepsy

2023
Astrocyte-neuron circuits in epilepsy.
    Neurobiology of disease, 2023, Volume: 179

    Topics: Adenosine; Astrocytes; Epilepsy; Glutamic Acid; Humans; Neurons

2023
Bipolar mania and epilepsy pathophysiology and treatment may converge in purine metabolism: A new perspective on available evidence.
    Neuropharmacology, 2023, Dec-15, Volume: 241

    Topics: Adenosine; Adenosine Triphosphate; Antimanic Agents; Bipolar Disorder; Epilepsy; Humans; Hydrocortisone; Mania; Purines; Uric Acid; Valproic Acid

2023
Epigenetics and epilepsy prevention: The therapeutic potential of adenosine and metabolic therapies.
    Neuropharmacology, 2020, 05-01, Volume: 167

    Topics: Adenosine; Animals; Anticonvulsants; Diet, Ketogenic; DNA Methylation; Epigenesis, Genetic; Epilepsy; Histones; Humans

2020
Role of Adenosine Kinase Inhibitor in Adenosine Augmentation Therapy for Epilepsy: A Potential Novel Drug for Epilepsy.
    Current drug targets, 2020, Volume: 21, Issue:3

    Topics: Adenosine; Adenosine Kinase; Animals; Anticonvulsants; Brain; Epilepsy; Humans; Mice; Protein Kinase Inhibitors

2020
RNA Editing in Neurological and Neurodegenerative Disorders.
    Methods in molecular biology (Clifton, N.J.), 2021, Volume: 2181

    Topics: Adenosine; Amyotrophic Lateral Sclerosis; Animals; Epilepsy; Humans; Inosine; Nervous System Diseases; Neurodegenerative Diseases; Phenotype; RNA Editing

2021
Adenosine-to-inosine RNA editing in neurological development and disease.
    RNA biology, 2021, Volume: 18, Issue:7

    Topics: Adenosine; Amyotrophic Lateral Sclerosis; Astrocytoma; Bipolar Disorder; Central Nervous System Neoplasms; Epilepsy; Humans; Inosine; Kv1.1 Potassium Channel; MicroRNAs; Receptor, Serotonin, 5-HT2C; Receptors, AMPA; RNA Editing; Schizophrenia; Spasms, Infantile

2021
ATP and adenosine-Two players in the control of seizures and epilepsy development.
    Progress in neurobiology, 2021, Volume: 204

    Topics: Adenosine; Adenosine Triphosphate; Epilepsy; Humans; Purines; Seizures

2021
The role of adenosine in epilepsy.
    Brain research bulletin, 2019, Volume: 151

    Topics: Adenosine; Adenosine Kinase; Animals; Anticonvulsants; Astrocytes; Brain; DNA Methylation; Epigenesis, Genetic; Epilepsy; Humans; Receptor, Adenosine A1; Seizures

2019
[Angiotensins as neuromodulators].
    Postepy biochemii, 2012, Volume: 58, Issue:4

    Topics: Adenosine; Angiotensins; Animals; Brain; Epilepsy; gamma-Aminobutyric Acid; Humans; Neurons; Neurotransmitter Agents; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System

2012
Modulation of adenosinergic system and its application for the treatment of epilepsy.
    Pharmacological reports : PR, 2014, Volume: 66, Issue:3

    Topics: Adenosine; Animals; Anticonvulsants; Epilepsy; Humans; Purinergic P1 Receptor Agonists

2014
Adenosinergic signaling in epilepsy.
    Neuropharmacology, 2016, Volume: 104

    Topics: 5'-Nucleotidase; Adenosine; Adenosine Kinase; Animals; Anticonvulsants; Astrocytes; Epilepsy; Genetic Therapy; Homeostasis; Humans; Nucleoside Transport Proteins; Receptors, Purinergic P1; Signal Transduction

2016
From unwitnessed fatality to witnessed rescue: Pharmacologic intervention in sudden unexpected death in epilepsy.
    Epilepsia, 2016, Volume: 57 Suppl 1

    Topics: Adenosine; Apnea; Brain Stem; Death, Sudden; Epilepsy; Humans; Hypoventilation; Narcotic Antagonists; Purinergic P1 Receptor Antagonists; Selective Serotonin Reuptake Inhibitors; Serotonin

2016
Role of the purinergic signaling in epilepsy.
    Pharmacological reports : PR, 2017, Volume: 69, Issue:1

    Topics: Adenosine; Adenosine Kinase; Animals; Epilepsy; Humans; Purinergic P2X Receptor Antagonists; Receptor, Adenosine A2A; Receptors, Purinergic; Receptors, Purinergic P2X7; Signal Transduction

2017
NTPDase and 5'-nucleotidase activities in physiological and disease conditions: new perspectives for human health.
    BioFactors (Oxford, England), 2007, Volume: 31, Issue:2

    Topics: 5'-Nucleotidase; Adenosine; Adenosine Triphosphate; Animals; Antigens, CD; Apyrase; Atherosclerosis; Blood Coagulation; Blood Platelets; Cell Communication; Demyelinating Diseases; Epilepsy; Humans; Metabolism, Inborn Errors; Myocardial Infarction; Neoplasms; Platelet Activation; Platelet Aggregation; Seizures; Signal Transduction; Tamoxifen; Thrombosis

2007
Engineered adenosine-releasing cells for epilepsy therapy: human mesenchymal stem cells and human embryonic stem cells.
    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2009, Volume: 6, Issue:2

    Topics: Adenosine; Animals; Embryonic Stem Cells; Epilepsy; Genetic Therapy; Humans; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells

2009
Adenosine augmentation therapies (AATs) for epilepsy: prospect of cell and gene therapies.
    Epilepsy research, 2009, Volume: 85, Issue:2-3

    Topics: Adenosine; Animals; Anticonvulsants; Cell- and Tissue-Based Therapy; Drug Delivery Systems; Epilepsy; Genetic Therapy; Humans; Mice; Stem Cell Transplantation

2009
Therapeutic epilepsy research: from pharmacological rationale to focal adenosine augmentation.
    Biochemical pharmacology, 2009, Dec-15, Volume: 78, Issue:12

    Topics: Adenosine; Adenosine Kinase; Animals; Anticonvulsants; Astrocytes; Brain; Drug Delivery Systems; Drug Implants; Epilepsy; Genetic Therapy; Humans; Mice; Neuroglia; Rats; Stem Cells

2009
The future of epilepsy treatment: focus on adeno-associated virus vector gene therapy.
    Drug news & perspectives, 2010, Volume: 23, Issue:5

    Topics: Adenosine; Animals; Dependovirus; Epilepsy; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Humans; Neuropeptides

2010
Inhibitory RNA in epilepsy: research tools and therapeutic perspectives.
    Epilepsia, 2010, Volume: 51, Issue:9

    Topics: Adenosine; Adenosine Kinase; Animals; Anticonvulsants; Brain; Epilepsy; Gene Expression Regulation; Genetic Therapy; Humans; Mice; MicroRNAs; RNA Interference

2010
Adenosine and ATP receptors in the brain.
    Current topics in medicinal chemistry, 2011, Volume: 11, Issue:8

    Topics: Adenosine; Adenosine Triphosphate; Animals; Brain; Dogs; Epilepsy; Female; Gene Expression; Humans; Ischemia; Mice; Neuralgia; Neuroglia; Neurons; Neurotransmitter Agents; Parkinson Disease; Rabbits; Rats; Receptors, Purinergic P1; Receptors, Purinergic P2; Synaptic Transmission

2011
Modulators of nucleoside metabolism in the therapy of brain diseases.
    Current topics in medicinal chemistry, 2011, Volume: 11, Issue:8

    Topics: Adenosine; Adenosine Kinase; Analgesics; Animals; Anticonvulsants; Brain; Brain Diseases; Epilepsy; Gene Expression; Humans; Metabolic Networks and Pathways; Mice; Mice, Knockout; Neuroprotective Agents; Pain; Protein Kinase Inhibitors; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Receptor, Adenosine A1; Receptor, Adenosine A2A; Schizophrenia; Signal Transduction; Sleep Wake Disorders

2011
Local delivery strategies in epilepsy: a focus on adenosine.
    Seizure, 2011, Volume: 20, Issue:5

    Topics: Adenosine; Animals; Blood-Brain Barrier; Brain; Drug Delivery Systems; Epilepsy; Genetic Therapy; Humans

2011
Adenosine dysfunction in epilepsy.
    Glia, 2012, Volume: 60, Issue:8

    Topics: Adenosine; Adenosine Kinase; Animals; Disease Models, Animal; Epilepsy; Humans; Metabolic Diseases; Phosphorylation

2012
[Adenosine and the anti-epileptic actions of ketogenic diets].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2012, Volume: 50, Issue:12

    Topics: Adenosine; Adenosine Kinase; Adenosine Triphosphate; Animals; Brain; Diet, Carbohydrate-Restricted; Diet, Ketogenic; Energy Metabolism; Epilepsy; Humans

2012
Glial cell changes in epilepsy: overview of the clinical problem and therapeutic opportunities.
    Neurochemistry international, 2013, Volume: 63, Issue:7

    Topics: Adenosine; Aquaporins; Calcium; Cell Transplantation; Epilepsy; Glucose; Humans; Neuroglia; Potassium Channels; Receptors, Glutamate

2013
Adenosine and epilepsy: from therapeutic rationale to new therapeutic strategies.
    The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2005, Volume: 11, Issue:1

    Topics: Adenosine; Brain; Cell Transplantation; Epilepsy; Homeostasis; Humans; Membrane Transport Modulators; Membrane Transport Proteins; Models, Neurological; Neural Inhibition; Nucleoside Transport Proteins; Purinergic P1 Receptor Agonists

2005
Modulatory role of adenosine and its receptors in epilepsy: possible therapeutic approaches.
    Neuroscience research, 2006, Volume: 56, Issue:1

    Topics: Adenosine; Animals; Anticonvulsants; Epilepsy; Humans; Protein Isoforms; Receptors, Purinergic P1

2006
Adenosine kinase, epilepsy and stroke: mechanisms and therapies.
    Trends in pharmacological sciences, 2006, Volume: 27, Issue:12

    Topics: Adenosine; Adenosine Kinase; Animals; Brain; Drug Delivery Systems; Enzyme Inhibitors; Epilepsy; Humans; Stroke

2006
Adenosine-based cell therapy approaches for pharmacoresistant epilepsies.
    Neuro-degenerative diseases, 2007, Volume: 4, Issue:1

    Topics: Adenosine; Adenosine Kinase; Animals; Anticonvulsants; Cell- and Tissue-Based Therapy; Drug Tolerance; Epilepsy; Humans

2007
Adenosine as a neuromodulator in neurological diseases.
    Current opinion in pharmacology, 2008, Volume: 8, Issue:1

    Topics: Adenosine; Adenosine Kinase; Alzheimer Disease; Animals; Brain Diseases; Brain Ischemia; Epilepsy; Humans; Huntington Disease; Pain; Parkinson Disease; Schizophrenia; Synaptic Transmission

2008
Adenine derivatives in epilepsy.
    Progress in clinical and biological research, 1980, Volume: 39

    Topics: Adenine Nucleotides; Adenosine; Animals; Anticonvulsants; Cyclic AMP; Epilepsy; Hypoxanthines; Inosine; Mice; Ouabain; Rats; Veratridine

1980
Regulation of endogenous adenosine levels in the CNS: potential for therapy in stroke, epilepsy and pain.
    Advances in experimental medicine and biology, 1994, Volume: 370

    Topics: Adenosine; Animals; Central Nervous System; Central Nervous System Diseases; Cerebrovascular Disorders; Epilepsy; Homeostasis; Humans; Pain; Receptors, Purinergic P1

1994
Functions of neuronal adenosine receptors.
    Naunyn-Schmiedeberg's archives of pharmacology, 2000, Volume: 362, Issue:4-5

    Topics: Adenosine; Animals; Calcium Channels; Epilepsy; Humans; Neurons; Neurotransmitter Agents; Potassium Channels; Receptors, Purinergic P1; Sleep

2000
The electrophysiology of adenosine in the mammalian central nervous system.
    Progress in neurobiology, 1991, Volume: 36, Issue:4

    Topics: Adenosine; Animals; Calcium; Calcium Channels; Central Nervous System; Electrophysiology; Epilepsy; Evoked Potentials; Humans; Hypoxia; Ion Channel Gating; Mammals; Neurotransmitter Agents; Potassium; Potassium Channels; Second Messenger Systems; Synapses

1991
Adenosine receptors in brain: neuromodulation and role in epilepsy.
    Annals of neurology, 1989, Volume: 26, Issue:6

    Topics: Adenosine; Anticonvulsants; Epilepsy; Humans; Receptors, Purinergic

1989
Purinergic mechanisms in epilepsy.
    Progress in neurobiology, 1988, Volume: 31, Issue:2

    Topics: Adenosine; Animals; Epilepsy; Humans

1988

Trials

2 trial(s) available for adenosine and Epilepsy

ArticleYear
Allopurinol as adjunctive therapy in intractable epilepsy: a double-blind and placebo-controlled trial.
    Archives of medical research, 2007, Volume: 38, Issue:3

    Topics: Adenosine; Adolescent; Adult; Allopurinol; Anticonvulsants; Double-Blind Method; Drug Therapy, Combination; Enzyme Inhibitors; Epilepsy; Female; Humans; Male; Middle Aged; Placebos

2007
Is ACTH a key to understanding anticonvulsant action?
    Developmental medicine and child neurology, 1998, Volume: 40, Issue:2

    Topics: Adenosine; Adrenocorticotropic Hormone; Anticonvulsants; Benzodiazepines; Binding Sites; Child; Child, Preschool; Cohort Studies; Diazepam; Electroencephalography; Epilepsy; Female; Follow-Up Studies; gamma-Aminobutyric Acid; Humans; Infant; Male; Receptors, GABA-A; Severity of Illness Index

1998

Other Studies

75 other study(ies) available for adenosine and Epilepsy

ArticleYear
A peptide blocking the ADORA1-neurabin interaction is anticonvulsant and inhibits epilepsy in an Alzheimer's model.
    JCI insight, 2022, 06-08, Volume: 7, Issue:11

    Topics: Adenosine; Alzheimer Disease; Animals; Anticonvulsants; Epilepsy; Humans; Mice; Microfilament Proteins; Nerve Tissue Proteins; Receptor, Adenosine A1; RGS Proteins

2022
The Effect of Adenosine Signaling on Memory Impairment Induced by Pentylenetetrazole in Zebrafish.
    Neurochemical research, 2023, Volume: 48, Issue:6

    Topics: Adenosine; Animals; Dipyridamole; Epilepsy; Pentylenetetrazole; Quality of Life; Seizures; Valproic Acid; Zebrafish

2023
Reactive A1 Astrocyte-Targeted Nucleic Acid Nanoantiepileptic Drug Downregulating Adenosine Kinase to Rescue Endogenous Antiepileptic Pathway.
    ACS applied materials & interfaces, 2023, Jun-28, Volume: 15, Issue:25

    Topics: Adenosine; Adenosine Kinase; Animals; Anticonvulsants; Astrocytes; Epilepsy; Mice; Nucleic Acids

2023
LncRNA CASC2 inhibits astrocytic activation and adenosine metabolism by regulating PTEN in pentylenetetrazol-induced epilepsy model.
    Journal of chemical neuroanatomy, 2020, Volume: 105

    Topics: Adenosine; Animals; Astrocytes; Epilepsy; Hippocampus; Male; Pentylenetetrazole; PTEN Phosphohydrolase; Rats; Rats, Sprague-Dawley; RNA, Long Noncoding

2020
Adenosine kinase deficiency: Three new cases and diagnostic value of hypermethioninemia.
    Molecular genetics and metabolism, 2021, Volume: 132, Issue:1

    Topics: Adenosine; Adenosine Kinase; Amino Acid Metabolism, Inborn Errors; Child; Developmental Disabilities; Epilepsy; Female; Genetic Predisposition to Disease; Glycine N-Methyltransferase; Humans; Infant; Infant, Newborn; Liver Diseases; Male; Retrospective Studies

2021
Elevated blood purine levels as a biomarker of seizures and epilepsy.
    Epilepsia, 2021, Volume: 62, Issue:3

    Topics: Adenosine; Adult; Animals; Biomarkers; Case-Control Studies; Epilepsy; Humans; Hypoxanthine; Inosine; Male; Mice; Mice, Inbred C57BL; Middle Aged; Point-of-Care Testing; Purines; Seizures; Severity of Illness Index; Status Epilepticus; Xanthine; Young Adult

2021
Astrocytes and Epilepsy.
    Neurochemical research, 2021, Volume: 46, Issue:10

    Topics: Adenosine; Amino Acid Transport System X-AG; Animals; Aquaporin 4; Astrocytes; Epilepsy; Gap Junctions; Humans; Potassium Channels, Inwardly Rectifying

2021
[The 2-chloride adenosine alleviates the damage of brain tissues in pentylenetetrazole-kindled epileptic mice by regulating P-glycoprotein expression].
    Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2017, Volume: 33, Issue:4

    Topics: Adenosine; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Epilepsy; Hippocampus; Humans; Male; Mice; Mice, Inbred C57BL; Pentylenetetrazole

2017
Nitrobenzylthioinosine mimics adenosine to attenuate the epileptiform discharge of hippocampal neurons from epileptic rats.
    Oncotarget, 2017, May-30, Volume: 8, Issue:22

    Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Disease Models, Animal; Epilepsy; Gene Expression; Hippocampus; Male; Patch-Clamp Techniques; Protein Transport; Pyramidal Cells; Rats; Receptor, Adenosine A1; Thioinosine

2017
Transient Disruption of Adenosine Signaling During Embryogenesis Triggers a Pro-epileptic Phenotype in Adult Zebrafish.
    Molecular neurobiology, 2018, Volume: 55, Issue:8

    Topics: Adenosine; Animals; Disease Susceptibility; Embryo, Nonmammalian; Embryonic Development; Epilepsy; Female; Fertilization; Larva; Male; Morpholinos; Motor Activity; Phenotype; Signal Transduction; Zebrafish

2018
Adenosine has two faces: Regionally dichotomous adenosine tone in a model of epilepsy with comorbid sleep disorders.
    Neurobiology of disease, 2018, Volume: 114

    Topics: Adenosine; Animals; Comorbidity; Disease Models, Animal; Epilepsy; Excitatory Postsynaptic Potentials; Female; Hippocampus; Male; Mice; Mice, Inbred C3H; Mice, Knockout; Organ Culture Techniques; Sleep Wake Disorders

2018
The combination of ribose and adenine promotes adenosine release and attenuates the intensity and frequency of epileptiform activity in hippocampal slices: Evidence for the rapid depletion of cellular ATP during electrographic seizures.
    Journal of neurochemistry, 2018, Volume: 147, Issue:2

    Topics: Adenine; Adenosine; Adenosine Triphosphate; Animals; Creatine; Electrophysiological Phenomena; Epilepsy; Extracellular Space; Hippocampus; In Vitro Techniques; Male; Microelectrodes; Rats; Rats, Sprague-Dawley; Ribose; Seizures; Synaptic Transmission

2018
Early detonation by sprouted mossy fibers enables aberrant dentate network activity.
    Proceedings of the National Academy of Sciences of the United States of America, 2019, 05-28, Volume: 116, Issue:22

    Topics: Adenosine; Animals; CA3 Region, Hippocampal; Dentate Gyrus; Disease Models, Animal; Epilepsy; Male; Mice; Mice, Transgenic; Mossy Fibers, Hippocampal; Optogenetics; Synapses

2019
Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis.
    The Journal of clinical investigation, 2013, Volume: 123, Issue:8

    Topics: Adenosine; Adenosine Kinase; Animals; Anticonvulsants; Azacitidine; Base Sequence; Brain; CpG Islands; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Drug Implants; Epigenesis, Genetic; Epilepsy; Male; Mice; Mossy Fibers, Hippocampal; Rats; Rats, Sprague-Dawley; Sequence Analysis, DNA

2013
Synthesis of a FTO inhibitor with anticonvulsant activity.
    ACS chemical neuroscience, 2014, Aug-20, Volume: 5, Issue:8

    Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Anticonvulsants; Blotting, Western; Catalytic Domain; Disease Models, Animal; Epilepsy; HeLa Cells; Humans; Mice; MicroRNAs; Mixed Function Oxygenases; Models, Chemical; Molecular Structure; Oxo-Acid-Lyases; Proteins

2014
Inhibition of adenosine metabolism induces changes in post-ictal depression, respiration, and mortality in genetically epilepsy prone rats.
    Epilepsy research, 2016, Volume: 119

    Topics: Adenine; Adenosine; Animals; Blood Gas Analysis; Brugada Syndrome; Disease Models, Animal; Enzyme Inhibitors; Epilepsy; Female; Genetic Predisposition to Disease; Incidence; Male; Oxygen; Rats; Respiration; Respiration Disorders; Seizures; Sex Characteristics; Tubercidin

2016
A pharmacodynamic analysis for the co-administration of inducers of CYP3A with ticagrelor: A cautionary tale in managing patients with acute coronary syndromes.
    International journal of cardiology, 2016, Jul-01, Volume: 214

    Topics: Acute Coronary Syndrome; Adenosine; Aged; Aged, 80 and over; Anticonvulsants; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Drug Administration Schedule; Drug Interactions; Epilepsy; Female; Humans; Male; Middle Aged; Registries; Ticagrelor; Treatment Outcome

2016
Silk polymer-based adenosine release: therapeutic potential for epilepsy.
    Biomaterials, 2008, Volume: 29, Issue:26

    Topics: Adenosine; Animals; Biocompatible Materials; Drug Carriers; Drug Delivery Systems; Epilepsy; Fibroins; Hippocampus; Humans; Kindling, Neurologic; Male; Materials Testing; Microspheres; Polymers; Prostheses and Implants; Rats; Rats, Sprague-Dawley; Silk

2008
Quantification of levetiracetam in human plasma by liquid chromatography-tandem mass spectrometry: application to therapeutic drug monitoring.
    Journal of pharmaceutical and biomedical analysis, 2008, Nov-04, Volume: 48, Issue:3

    Topics: Adenosine; Anticonvulsants; Calibration; Chromatography, Liquid; Drug Monitoring; Drug Stability; Drug Storage; Epilepsy; Freezing; Humans; Levetiracetam; Metabolic Clearance Rate; Piracetam; Quality Control; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Tandem Mass Spectrometry; Time Factors

2008
Adenosine receptor antagonists alter the stability of human epileptic GABAA receptors.
    Proceedings of the National Academy of Sciences of the United States of America, 2008, Sep-30, Volume: 105, Issue:39

    Topics: Adenosine; Adenosine Deaminase; Adult; Animals; Anticonvulsants; Cerebral Cortex; Epilepsy; Female; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Male; Neurons; Oocytes; Purinergic P1 Receptor Antagonists; Pyramidal Tracts; Pyrimidines; Quinazolines; Rats; Receptors, GABA-A; Triazoles; Xanthines; Xenopus

2008
Effects of progesterone on total brain tissue adenosine deaminase activity in experimental epilepsy.
    The International journal of neuroscience, 2009, Volume: 119, Issue:2

    Topics: Adenosine; Adenosine Deaminase; Animals; Brain; Convulsants; Disease Models, Animal; Epilepsy; Female; Male; Mice; Pentylenetetrazole; Polyunsaturated Alkamides; Progesterone; Propionates; Receptor, Adenosine A1; Receptors, GABA-A

2009
Antiepileptic effects of silk-polymer based adenosine release in kindled rats.
    Experimental neurology, 2009, Volume: 219, Issue:1

    Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Anticonvulsants; Disease Models, Animal; Drug Delivery Systems; Drug Implants; Electric Stimulation; Epilepsy; Hippocampus; Kindling, Neurologic; Male; Polymers; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Seizures; Silk; Treatment Outcome

2009
Adenosine A2A receptor deficient mice are partially resistant to limbic seizures.
    Naunyn-Schmiedeberg's archives of pharmacology, 2009, Volume: 380, Issue:3

    Topics: Adenosine; Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Epilepsy; Male; Mice; Mice, Knockout; Pentylenetetrazole; Pilocarpine; Receptor, Adenosine A2A; Seizures

2009
A novel mouse model for sudden unexpected death in epilepsy (SUDEP): role of impaired adenosine clearance.
    Epilepsia, 2010, Volume: 51, Issue:3

    Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Caffeine; Cause of Death; Death, Sudden; Disease Models, Animal; Enzyme Inhibitors; Epilepsy; Kainic Acid; Mice; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Risk Factors; Seizures; Survival Analysis; Tubercidin

2010
Epileptogenic insult alters endogenous adenosine control on long-term changes in synaptic strength by theta pattern stimulation in hippocampus area CA1.
    Synapse (New York, N.Y.), 2011, Volume: 65, Issue:3

    Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Convulsants; Epilepsy; Excitatory Postsynaptic Potentials; Hippocampus; Kindling, Neurologic; Male; Neuronal Plasticity; Organ Culture Techniques; Pentylenetetrazole; Rats; Seizures; Theta Rhythm

2011
Astrocytes derived from fetal neural progenitor cells as a novel source for therapeutic adenosine delivery.
    Seizure, 2010, Volume: 19, Issue:7

    Topics: Adenosine; Adenosine Kinase; Animals; Astrocytes; Blotting, Western; Cell Differentiation; Chromatography, Liquid; Epilepsy; Female; Fetal Stem Cells; Immunohistochemistry; Injections, Intraventricular; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Mice, Knockout; Polymerase Chain Reaction; Stem Cell Transplantation

2010
The interactions of nitric oxide and adenosine on penicillin-induced epileptiform activity in rats.
    Acta neurobiologiae experimentalis, 2011, Volume: 71, Issue:2

    Topics: Action Potentials; Adenosine; Animals; Brain Waves; Disease Models, Animal; Drug Interactions; Electroencephalography; Enzyme Inhibitors; Epilepsy; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Penicillins; Rats; Rats, Wistar; Theophylline

2011
Endogenous adenosine induces NMDA receptor-independent persistent epileptiform discharges in dorsal and ventral hippocampus via activation of A2 receptors.
    Epilepsy research, 2012, Volume: 100, Issue:1-2

    Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Epilepsy; Excitatory Postsynaptic Potentials; Hippocampus; Male; Rats; Rats, Wistar; Receptors, Adenosine A2; Receptors, N-Methyl-D-Aspartate; Synaptic Potentials

2012
FTO, RNA epigenetics and epilepsy.
    Epigenetics, 2012, Volume: 7, Issue:10

    Topics: 3' Untranslated Regions; Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Central Nervous System; Epigenesis, Genetic; Epilepsy; Gene Expression Regulation; Humans; Methylation; MicroRNAs; Proteins; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcriptome

2012
Seizure suppression by adenosine-releasing cells is independent of seizure frequency.
    Epilepsia, 2002, Volume: 43, Issue:8

    Topics: Adenosine; Animals; Capsules; Cell Survival; Cell Transplantation; Cerebral Ventricles; Cricetinae; Electroencephalography; Epilepsy; Kidney; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains

2002
Contribution of ionotropic glutamate receptors and voltage-dependent calcium channels to the potentiation phenomenon induced by transient pentylenetetrazol in the CA1 region of rat hippocampal slices.
    Brain research, 2003, Jan-03, Volume: 959, Issue:1

    Topics: Adenosine; Animals; Calcium Channel Blockers; Calcium Channels; Epilepsy; Evoked Potentials; GABA Antagonists; Hippocampus; Long-Term Potentiation; Male; Neurotransmitter Agents; Organ Culture Techniques; Pentylenetetrazole; Rats; Receptors, AMPA; Receptors, Glutamate

2003
Changes in nucleotide hydrolysis in rat blood serum induced by pentylenetetrazol-kindling.
    Brain research. Molecular brain research, 2003, Jun-10, Volume: 114, Issue:2

    Topics: 5'-Nucleotidase; Adenine Nucleotides; Adenosine; Animals; Apyrase; Biomarkers; Brain; Convulsants; Disease Models, Animal; Epilepsy; Female; Hydrolysis; Kindling, Neurologic; Nucleotidases; Pentylenetetrazole; Presynaptic Terminals; Rats; Rats, Wistar; Synaptic Transmission

2003
Amino acid composition of brain cysts: levels of excitatory amino acids in cyst fluid fail to predict seizures.
    Epilepsy research, 2003, Volume: 55, Issue:3

    Topics: Adenosine; Adolescent; Adult; Anticonvulsants; Aspartic Acid; Brain; Child; Cysts; Electroencephalography; Epilepsy; Excitatory Amino Acids; Female; Glutamic Acid; Humans; Male; Middle Aged; Time Factors

2003
The anticonvulsant action of propofol on epileptiform activity in rat hippocampal slices.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:4

    Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Aminophylline; Anesthetics, Intravenous; Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; Electric Stimulation; Epilepsy; Excitatory Postsynaptic Potentials; Female; GABA Antagonists; Hippocampus; In Vitro Techniques; Male; Phosphodiesterase Inhibitors; Picrotoxin; Propofol; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Theobromine; Xanthines

2004
Adenosine and ATP link PCO2 to cortical excitability via pH.
    Neuron, 2005, Dec-22, Volume: 48, Issue:6

    Topics: Acids; Adenosine; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Carbon Dioxide; Epilepsy; Excitatory Postsynaptic Potentials; Extracellular Fluid; Hippocampus; Hydrogen-Ion Concentration; Hypercapnia; Hypocapnia; Membrane Potentials; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptors, Purinergic P2; Synaptic Transmission; Up-Regulation

2005
The support of adenosine release from adenosine kinase deficient ES cells by silk substrates.
    Biomaterials, 2006, Volume: 27, Issue:26

    Topics: Adenosine; Adenosine Kinase; Animals; Biocompatible Materials; Capsules; Cell Differentiation; Cell Proliferation; Cells, Cultured; Collagen Type I; Delayed-Action Preparations; Embryo, Mammalian; Epilepsy; Fibroins; Glucose; Hydrophobic and Hydrophilic Interactions; Mice; Mutation; Neuroglia; Peptides; Stem Cells

2006
Anticonvulsant effects of focal and intracerebroventricular adenosine on penicillin-induced epileptiform activity in rats.
    Brain research, 2007, Jan-05, Volume: 1127, Issue:1

    Topics: Action Potentials; Adenosine; Animals; Anticonvulsants; Brain; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Electroencephalography; Epilepsy; Female; Injections, Intraventricular; Penicillins; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Theophylline

2007
Suppression of kindling epileptogenesis by adenosine releasing stem cell-derived brain implants.
    Brain : a journal of neurology, 2007, Volume: 130, Issue:Pt 5

    Topics: Adenosine; Adenosine Kinase; Animals; Brain; Cells, Cultured; Embryonic Stem Cells; Epilepsy; Genetic Engineering; Kindling, Neurologic; Male; Models, Animal; Paracrine Communication; Rats; Rats, Sprague-Dawley

2007
Brain methylation and epileptogenesis: the case of methionine sulfoximine.
    Annals of neurology, 1984, Volume: 16 Suppl

    Topics: Adenosine; Animals; Brain; Epilepsy; Histamine; Homocysteine; Methionine; Methionine Sulfoximine; Methylation; Methylhistamines; Mice; Nerve Tissue Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine

1984
Adenosine A1 receptors in the rat brain in the kindling model of epilepsy.
    European journal of pharmacology, 1994, Nov-24, Volume: 265, Issue:3

    Topics: Adenosine; Animals; Aspartic Acid; Brain; Epilepsy; In Vitro Techniques; Kindling, Neurologic; Male; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Synaptosomes

1994
Epileptogenic actions of xanthines in relation to their affinities for adenosine A1 receptors in CA3 neurons of hippocampal slices (guinea pig).
    Brain research, 1994, Mar-21, Volume: 640, Issue:1-2

    Topics: Adenosine; Animals; Caffeine; Calcium; Cyclic AMP; Epilepsy; Guinea Pigs; Hippocampus; In Vitro Techniques; Magnesium; Membrane Potentials; Neurons; Phenylisopropyladenosine; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Xanthines

1994
The effect of calcium removal on the suppression by adenosine of epileptiform activity in the hippocampus: demonstration of desensitization.
    British journal of pharmacology, 1994, Volume: 112, Issue:1

    Topics: Adenosine; Animals; Baclofen; Calcium; Calcium-Transporting ATPases; Electric Stimulation; Epilepsy; Evoked Potentials; Hippocampus; Male; Purines; Pyramidal Cells; Rats; Rats, Wistar; Synapses; Terpenes; Thapsigargin

1994
Characterization of adenosine receptor-mediated generation of cyclic AMP in slices of rat cerebral cortex with chronic epileptic activity.
    Neurochemical research, 1993, Volume: 18, Issue:9

    Topics: 2-Chloroadenosine; Adenosine; Animals; Cerebral Cortex; Chronic Disease; Cyclic AMP; Electroencephalography; Epilepsy; Ferrous Compounds; In Vitro Techniques; Male; Phenylisopropyladenosine; Rats; Rats, Wistar; Receptors, Purinergic P1

1993
Involvement of adenosine-sensitive cyclic AMP-generating systems in cobalt-induced epileptic activity in the rat.
    Journal of neurochemistry, 1993, Volume: 61, Issue:6

    Topics: 2-Chloroadenosine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Animals; Cerebral Cortex; Cobalt; Cyclic AMP; Electroencephalography; Epilepsy; In Vitro Techniques; Male; Microinjections; Motor Activity; Rats; Rats, Wistar; Theophylline

1993
The adenosine binding enhancer, PD 81,723, inhibits epileptiform bursting in the hippocampal brain slice.
    Brain research, 1993, Aug-13, Volume: 619, Issue:1-2

    Topics: Adenosine; Animals; Axons; Electric Stimulation; Epilepsy; Hippocampus; In Vitro Techniques; Magnesium; Male; Neurons; Pyramidal Tracts; Rats; Thiophenes

1993
Genetic variation in immediate and delayed postictal refractory period in rats.
    Brain research, 1996, May-20, Volume: 721, Issue:1-2

    Topics: Adenosine; Animals; Caffeine; Central Nervous System Stimulants; Epilepsy; Genetic Variation; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Refractory Period, Electrophysiological; Species Specificity

1996
Modulation by adenine nucleotides of epileptiform activity in the CA3 region of rat hippocampal slices.
    British journal of pharmacology, 1998, Volume: 123, Issue:1

    Topics: Adenine Nucleotides; Adenosine; Adenosine Deaminase; Adenosine Triphosphate; Animals; Electric Stimulation; Epilepsy; Hippocampus; In Vitro Techniques; Male; Neurons; Platelet Aggregation Inhibitors; Pyridoxal Phosphate; Rats; Rats, Wistar; Suramin; Theophylline

1998
Adenylosuccinase deficiency with neonatal onset severe epileptic seizures and sudden death.
    Neuropediatrics, 1998, Volume: 29, Issue:1

    Topics: Adenosine; Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Anticonvulsants; Death, Sudden; Epilepsy; Humans; Infant, Newborn; Male; Purine-Pyrimidine Metabolism, Inborn Errors; Ribonucleotides

1998
Epileptiform activity in supragranular and infragranular blocks of mouse neocortex.
    Epilepsy research, 1998, Volume: 31, Issue:1

    Topics: Adenosine; Animals; Culture Techniques; Diffusion Chambers, Culture; Dose-Response Relationship, Drug; Epilepsy; Evoked Potentials; Female; Magnesium Deficiency; Male; Mice; Mice, Inbred BALB C; Models, Biological; Neocortex; Osmolar Concentration; Perfusion; Somatosensory Cortex

1998
The anticonvulsant BW534U87 depresses epileptiform activity in rat hippocampal slices by an adenosine-dependent mechanism and through inhibition of voltage-gated Na+ channels.
    British journal of pharmacology, 1999, Volume: 128, Issue:5

    Topics: Action Potentials; Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Anticonvulsants; Brain Chemistry; CHO Cells; Cricetinae; Electrophysiology; Enzyme Inhibitors; Epilepsy; Female; Hippocampus; In Vitro Techniques; Ion Channel Gating; Magnesium; Male; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sodium Channels; Triazoles

1999
Effects of an adenosine analogue administration on the striatal NMDA receptors in an experimental model of epilepsy.
    Neurochemistry international, 2000, Volume: 36, Issue:3

    Topics: 3-Mercaptopropionic Acid; Adenosine; Animals; Cell Membrane; Convulsants; Corpus Striatum; Dizocilpine Maleate; Epilepsy; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tritium; Up-Regulation

2000
N(6)-2-(4-aminophenyl)ethyl-adenosine enhances the anticonvulsive action of conventional antiepileptic drugs in the kindling model of epilepsy in rats.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2000, Volume: 10, Issue:4

    Topics: Adenosine; Amygdala; Animals; Anticonvulsants; Avoidance Learning; Carbamazepine; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Epilepsy; Kindling, Neurologic; Male; Rats; Rats, Wistar; Theophylline; Valproic Acid

2000
Effects of postsynaptic GABA(B) receptor activation on epileptiform activity in hippocampal slices.
    Neuropharmacology, 2001, Volume: 40, Issue:1

    Topics: Adenosine; Animals; Baclofen; Dentate Gyrus; Electrodes, Implanted; Epilepsy; Excitatory Postsynaptic Potentials; Female; GABA Agonists; GABA-B Receptor Agonists; GTP-Binding Proteins; Hippocampus; In Vitro Techniques; Male; Potassium; Rats; Rats, Sprague-Dawley; Synapses

2001
K(ATP) channel openers, adenosine agonists and epileptic preconditioning are stress signals inducing hippocampal neuroprotection.
    Neuroscience, 2000, Volume: 100, Issue:3

    Topics: Adenosine; Adenosine Triphosphate; Animals; Apoptosis; Cromakalim; Epilepsy; Hippocampus; HSP70 Heat-Shock Proteins; Male; Necrosis; Neuroprotective Agents; Phenylisopropyladenosine; Potassium Channels; Rats; Rats, Wistar; Signal Transduction; Stress, Physiological

2000
Effects of adenosine administration on spike-wave discharge frequency in genetically epileptic rats.
    Clinical and experimental pharmacology & physiology, 2001, Volume: 28, Issue:8

    Topics: Adenosine; Animals; Disease Models, Animal; Electroencephalography; Epilepsy; Male; Rats

2001
Effects of angiotensin III and angiotensin IV on pentylenetetrazol seizure susceptibility (threshold and kindling): interaction with adenosine A(1) receptors.
    Brain research bulletin, 2001, Sep-15, Volume: 56, Issue:2

    Topics: Adenosine; Angiotensin II; Angiotensin III; Angiotensins; Animals; Brain; Convulsants; Disease Susceptibility; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Kindling, Neurologic; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Seizures; Xanthines

2001
[Adenosine inhibits spontaneous and glutamate induced discharges of hippocampal CA1 neurons].
    Sheng li xue bao : [Acta physiologica Sinica], 2000, Volume: 52, Issue:4

    Topics: Adenosine; Animals; Electrophysiology; Epilepsy; Female; Glutamic Acid; Glyburide; Hippocampus; In Vitro Techniques; Male; Microelectrodes; Neurons; Rats; Rats, Sprague-Dawley

2000
Increased responses to adenosine and 2-chloroadenosine of cyclic AMP-generating systems in the primary cortical region of cobalt-induced epilepsy in the rat.
    The Japanese journal of physiology, 1992, Volume: 42, Issue:1

    Topics: 2-Chloroadenosine; Action Potentials; Adenosine; Animals; Cerebral Cortex; Cobalt; Cyclic AMP; Epilepsy; Male; Rats; Rats, Inbred Strains

1992
Adenosine-mediated synaptic inhibition: partial blockade by barium does not prevent anti-epileptiform activity.
    Synapse (New York, N.Y.), 1992, Volume: 11, Issue:3

    Topics: Action Potentials; Adenosine; Animals; Barium; Electrodes; Epilepsy; Evoked Potentials; Female; In Vitro Techniques; Male; Neurons; Potassium Channels; Rats; Synapses; Synaptic Transmission

1992
Depression of burst discharges and of neuronal calcium influx by adenosine.
    Epilepsy research. Supplement, 1992, Volume: 8

    Topics: Adenosine; Animals; Calcium; Calcium Channels; Culture Techniques; Dendrites; Epilepsy; Hippocampus; Neural Inhibition; Neurons; Potassium; Potassium Channels; Protein Kinase C; Rats; Receptors, Purinergic; Synapses; Synaptic Membranes; Synaptic Transmission

1992
Amino acid neurotransmitter interactions in 'area tempestas': an epileptogenic trigger zone in the deep prepiriform cortex.
    Epilepsy research. Supplement, 1992, Volume: 8

    Topics: 2-Amino-5-phosphonovalerate; Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Amygdala; Animals; Bicuculline; Brain Mapping; Carbachol; Dominance, Cerebral; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Ibotenic Acid; Kainic Acid; Limbic System; Muscimol; Quisqualic Acid; Rats; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate

1992
Adenosine: a potential mediator of seizure arrest and postictal refractoriness.
    Annals of neurology, 1992, Volume: 32, Issue:5

    Topics: Adenosine; Adult; Brain Chemistry; Dialysis; Electroencephalography; Epilepsy; Female; Hippocampus; Humans; Male; Potassium

1992
Adenosine and seizure termination.
    Annals of neurology, 1991, Volume: 29, Issue:5

    Topics: Adenosine; Epilepsy; Humans

1991
Influence of CGS 15943 A (a nonxanthine adenosine antagonist) on the protection offered by a variety of antiepileptic drugs against maximal electroshock-induced seizures in mice.
    Journal of neural transmission. General section, 1991, Volume: 86, Issue:2

    Topics: Adenosine; Animals; Anticonvulsants; Disease Susceptibility; Drug Interactions; Electroshock; Epilepsy; Male; Mice; Motor Activity; Quinazolines; Triazoles

1991
Alterations of A1 adenosine receptors in different mouse brain areas after pentylentetrazol-induced seizures, but not in the epileptic mutant mouse 'tottering'.
    Brain research, 1990, Nov-26, Volume: 534, Issue:1-2

    Topics: Adenosine; Animals; Brain; Epilepsy; Kinetics; Mice; Mice, Inbred BALB C; Mice, Neurologic Mutants; Organ Specificity; Pentylenetetrazole; Receptors, Purinergic; Seizures; Species Specificity

1990
NMDA-receptor-independent effects of low magnesium: involvement of adenosine.
    Brain research, 1990, Feb-05, Volume: 508, Issue:2

    Topics: Action Potentials; Adenosine; Animals; Epilepsy; Hippocampus; In Vitro Techniques; Magnesium; Male; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Theophylline

1990
Regional difference in responsiveness of adenosine-sensitive cyclic AMP-generating systems in chronic epileptic cerebral cortex of the rat.
    Journal of neurochemistry, 1990, Volume: 55, Issue:4

    Topics: 2-Chloroadenosine; Adenosine; Adenosine Deaminase; Animals; Cerebral Cortex; Cyclic AMP; Epilepsy; In Vitro Techniques; Male; Organ Specificity; Rats; Rats, Inbred Strains; Receptors, Purinergic; Theophylline

1990
Endogenous adenosine can reduce epileptiform activity in the human epileptogenic cortex maintained in vitro.
    Neuroscience letters, 1989, Nov-20, Volume: 106, Issue:1-2

    Topics: Adenosine; Cerebral Cortex; Epilepsy; Humans; In Vitro Techniques; Thioinosine

1989
Adenosine inhibits epileptiform activity arising in hippocampal area CA3.
    British journal of pharmacology, 1986, Volume: 87, Issue:4

    Topics: Adenosine; Adenosine Deaminase; Animals; Dipyridamole; Enzyme Induction; Epilepsy; Evoked Potentials; Female; Hippocampus; In Vitro Techniques; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Purinergic; Synaptosomes; Theophylline

1986
Antiepileptic effects of N6-L-phenylisopropyladenosine (L-PIA) on penicillin-induced epileptogenic focus in rabbits.
    Pharmacological research communications, 1988, Volume: 20, Issue:7

    Topics: Adenosine; Animals; Anticonvulsants; Electrodes, Implanted; Electroencephalography; Epilepsy; Male; Penicillins; Phenylisopropyladenosine; Rabbits

1988
The adenosine hypothesis of epilepsy.
    Medical hypotheses, 1988, Volume: 27, Issue:4

    Topics: Adenosine; Animals; Anticonvulsants; Central Nervous System; Epilepsy; Humans; Models, Biological; Receptors, Purinergic

1988
Comparative influence of calcium blocker and purinergic drugs on epileptiform bursting in rat hippocampal slices.
    Brain research, 1988, Feb-16, Volume: 441, Issue:1-2

    Topics: Adenosine; Animals; Caffeine; Calcium; Epilepsy; Hippocampus; In Vitro Techniques; Magnesium; Male; Neurons; Nifedipine; Phenylisopropyladenosine; Pyramidal Tracts; Rats; Rats, Inbred Strains; Verapamil

1988
Regulation of cerebral blood flow (CBF) during hypoxia and epileptic seizures.
    Advances in experimental medicine and biology, 1985, Volume: 191

    Topics: 2-Chloroadenosine; Adenosine; Amobarbital; Animals; Cats; Cerebrovascular Circulation; Cyanides; Epilepsy; Hypoxia; Theophylline

1985
Protective effect of adenosine and nicotinamide against audiogenic seizure.
    Biochemical pharmacology, 1974, Oct-15, Volume: 23, Issue:20

    Topics: Acoustic Stimulation; Adenosine; Adenosine Triphosphate; Animals; Blood Pressure; Brain Chemistry; Caffeine; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Male; Mice; Mice, Inbred Strains; NAD; Niacinamide; Norepinephrine; Phosphocreatine; Phosphorus Radioisotopes; Time Factors

1974
Adenosine deaminase in cerebrospinal fluid.
    Enzymologia, 1972, Dec-31, Volume: 43, Issue:6

    Topics: Adenosine; Adolescent; Adult; Aged; Aminohydrolases; Brain; Brain Neoplasms; Central Nervous System Diseases; Cerebellum; Cerebrospinal Fluid Proteins; Cerebrovascular Disorders; Child; Chlorides; Epilepsy; Female; Glioma; Glucose; Humans; Male; Meningioma; Meningitis; Middle Aged

1972