adenosine has been researched along with Disease Models, Animal in 850 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (3.53) | 18.7374 |
| 1990's | 102 (12.00) | 18.2507 |
| 2000's | 262 (30.82) | 29.6817 |
| 2010's | 347 (40.82) | 24.3611 |
| 2020's | 109 (12.82) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, WP; Chern, Y; Fang, JM; Huang, NK; Lin, CI; Lin, YL | 1 |
| Braisted, J; Dranchak, P; Earnest, TW; Gu, X; Hoon, MA; Inglese, J; Oliphant, E; Solinski, HJ | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Bhattarai, A; Bhola, R; Carlsson, J; Chia, LY; Christie, MJ; Christopoulos, A; Cowie-Kent, I; Danev, R; Draper-Joyce, CJ; Glukhova, A; Imlach, WL; May, LT; Miao, Y; Nguyen, ATN; O'Sullivan, K; Panel, N; Scammells, P; Sexton, PM; Thal, DM; Valant, C; Venugopal, H; Wang, J; White, PJ; Wootten, D | 1 |
| Cen, S; Che, Y; Li, J; Li, M; Li, Z; Lin, J; Liu, W; Shen, H; Su, Z; Wang, P; Wu, Y; Xie, Z; Ye, F; Ye, G; Yu, W; Zheng, G | 1 |
| Amento, E; Kang, GJ; Kaur, M; Mechanic, J; Ravikumar, P; Welihinda, A; Yadav, S | 1 |
| Cheng, L; Hou, C; Xiao, L; Yan, N; Zhao, L; Zheng, S | 1 |
| He, B; Wang, J | 1 |
| Fan, L; Shen, F; Sun, D; Wang, Z; Yang, H | 1 |
| Chen, X; Dong, J; Gong, W; Guo, B; Jiang, Q; Qin, J; Shao, X; Shen, S; Shi, T; Shi, Y; Zhang, L | 1 |
| Chang, Y; He, Y; Huang, H; Huang, S; Jiao, X; Jin, H; Jin, Z; Li, H; Li, M; Ren, G; Sun, W; Wang, C; Xie, Q; Zhang, N; Zhang, X | 1 |
| Gu, C; Li, X; Liu, Y; Wang, T; Yu, L | 1 |
| Dong, J; Huang, X; Qin, J; Tang, W; Tang, Z; Teng, F; Wang, S; Wei, Y; Wuniqiemu, T; Zhou, Y; Zhu, X | 1 |
| Babusis, D; Barrett, KT; Bilello, JP; Chan, J; Chun, K; Cihlar, T; Cox, RM; DuPont, V; Greninger, AL; Kalla, R; Lieber, CM; Lin, MJ; Lye, D; Mackman, RL; Martinez-Sobrido, L; Plemper, RK; Sourimant, J; Wolf, JD; Ye, C | 1 |
| Jiang, M; Shen, L; Yu, Y; Zhao, J | 1 |
| Biros, E; Dobson, GP; Letson, HL; Morris, JL | 2 |
| Bai, H; Gao, L; Jiao, G; Li, T; Liu, L; Ma, T; Song, X; Wang, X; Zhang, Z | 1 |
| Du, T; Han, R; Li, C; Li, L; Liu, R; Liu, S; Meng, K; Shen, Y; Xiu, J; Xu, L; Xu, Q; Zhu, C; Zhu, W | 1 |
| Bingham, JR; Conner, JR; Eckert, MJ; Franko, JJ; Ieronimakis, N; Lammers, DT; Parsons, ME; Reynolds, GD; Vu, MM | 1 |
| Kosmowska, B; Wardas, J | 1 |
| Babu, YS; Bielefeldt-Ohmann, H; Bowen, R; Demarest, JF; DeSpirito, M; Hartwig, A; Mathis, A; Taylor, R; Walling, DM | 1 |
| Dong, Z; Kwon, SH; Lee, BR; Lee, CM; Lee, HK; Lee, TJ; Li, C; O'Connor, PM | 1 |
| Patel, A; Patel, L; Patel, M; Patel, S; Shah, S; Shah, U; Solanki, N | 1 |
| Chen, CC; Fu, HI; Hsu, JH; Lee, LY; Tung, KC | 1 |
| Fábera, P; Kubová, H; Mareš, P; Tsenov, G; Uttl, L | 1 |
| Acton, G; Ay, F; Brennan, PA; Chou, TF; Chudley, L; Davies, JH; Dicker, M; Dobbs, NA; Eschweiler, S; Essame, L; Friberg, G; Hackshaw, A; Halbert, G; Jeffrey, D; Jones, TM; Kelly, F; King, E; Kronenberg, M; Li, Y; Loadman, PM; Lopez-Guadamillas, E; McCann, K; McCaul, JA; Mondal, M; Okkenhaug, K; Ottensmeier, CH; Paterson, C; Ramírez-Suástegui, C; Sacco, JJ; Schache, AG; Seumois, G; Shaw, R; Simon, H; Singh, RP; Thomas, GJ; Thomas, J; Vanhaesebroeck, B; Vijayanand, P; von Witzleben, A; Wang, A; Wilson, W; Wood, O | 1 |
| Fang, L; Huang, J; Wang, J | 1 |
| Bali, V; Eltzschig, HK; Fried, DE; Grubišić, V; Gulbransen, BD; Mazei-Robison, MS; Robson, SC | 1 |
| Chen, YS; Hsieh, ST; Wang, YC | 1 |
| Chen, K; Dai, X; Xie, Y | 1 |
| Huang, J; Jin, H; Wang, Y | 1 |
| Farinha-Ferreira, M; Rei, N; Ribeiro, JA; Sebastião, AM; Valente, CA; Vaz, SH | 1 |
| Ganama, M; Hua, X; Tilley, S; Varga, SM; Waldstein, KA | 1 |
| Han, YY; Huang, SY; Li, CH; Liu, L; Mai, ZF; Shang, YJ; Su, ZY; Zeng, ZW | 1 |
| Biros, E; Birosova, E; Moran, CS | 1 |
| Illes, P; Li, J; Ren, WJ; Rubini, P; Tang, Y; Yuan, ZQ; Zhao, YF | 1 |
| Iguchi, K; Miyoshi, N; Mochizuki, J; Nagashima, K; Unno, K; Yamamoto, H | 1 |
| Kurata, Y; Mimura, I; Nangaku, M; Tanaka, T; Yamazaki, T | 1 |
| Gong, X; Peng, F; Yi, J; Zhao, J | 1 |
| Belo, RF; Correia-de-Sá, P; Diógenes, MJ; Lopes, AL; Magalhães-Cardoso, T; Miranda-Lourenço, C; Rei, N; Rosa, J; Sebastião, AM; Silva, D; Viais, R; Vieira, C | 1 |
| Arbab, M; Aytan, D; Bezler, AK; Fakhari, M; Junger, WG; Kondo, Y; Ledderose, C; Slubowski, CJ; Sueyoshi, K; Sumi, Y | 1 |
| Agostinho, P; Canas, PM; Cunha, RA; Ferreira, SG; Gonçalves, FQ; Gonçalves, N; Lemos, C; Lopes, JP; Rial, D; Silva, AC; Silva, HB; Tomé, ÂR | 1 |
| Li, SM; Ma, LL; Wang, BH; Xie, W; Xu, YQ | 1 |
| Chao, Y; Ji, W; Jin, H; Lin, S; Min, W; Qi, D; Que, B; Wang, X; Yang, M; Ying, X; Yuan, Z; Zhang, H | 1 |
| Baber, SR; Cornett, EM; Kaye, AD; Kaye, RJ; Sharief, MT | 1 |
| Che, Z; Chu, Y; Liu, F; Liu, J; Ma, Y; McGrath, M; Song, C; Wu, L; Wu, M; Xu, W; Yang, D; Zhang, Q; Zhang, W | 1 |
| Faghfoori, MH; Faghfoori, Z; Gursoy, R; Metz, GAS; Mirghani, SJ; Moghanlou, AE; Seydyousefi, M | 1 |
| Liu, N; Ma, X; Qiu, A; Shi, Y; Tao, M; Wang, Y; Zang, X; Zhuang, S | 1 |
| Hackert, T; Roth, S | 1 |
| Cheng, X; Cui, R; Song, C; Yang, L; Yue, B; Zhang, Z; Zhao, G | 1 |
| Bonsi, P; Goodchild, R; Grundmann-Hauser, K; Imbriani, P; Martella, G; Nguyen, HP; Ott, T; Pisani, A; Ponterio, G; Riess, O; Schulze-Hentrich, JM; Sciamanna, G; Tassone, A; Tomczak, C; Wassouf, Z; Yu-Taeger, L | 1 |
| Chen, L; Chen, Z; Deng, Q; Dinglin, X; Hou, X; Huang, H; Li, D; Ling, Y; Lv, Z; Ma, S; Peng, Y; Wang, H; Wu, Y | 1 |
| Chen, X; He, B; Liu, X; Pan, B; Pan, Y; Sun, H; Sun, L; Wang, S; Xia, X; Xu, M; Xu, X; Zeng, K | 1 |
| Chen, X; Hao, X; Huang, J; Lan, T; Li, H; Li, J; Liao, H; Liao, M; Liu, H; Wu, H; Xie, K; Xu, L; Yan, X; Yuan, K; Zeng, Y; Zhang, D | 1 |
| Chen, Z; Liu, X; Yang, C; Yu, H | 1 |
| Gao, Y; Ge, W; Liu, J; Sun, Q; Xu, X; Yang, X; Yang, Y; Zhang, J; Zhao, Y | 1 |
| Jeong, W; Jun, IG; Kim, K; Park, JY | 1 |
| Casey, M; Gandhi, MK; Nakamura, K; Oey, H; Smyth, MJ; Stagg, J; Vari, F | 1 |
| Dobson, GP; Granfeldt, A; Jensen, TH; Letson, HL; Mattson, TH | 1 |
| Chen, S; Deng, Z; Kong, Y; Liang, X; Lv, N; Peng, Q; Wang, L; Yuan, J | 1 |
| Wang, D; Zheng, X | 1 |
| Chen, K; Huang, J; Ran, H; Wang, J; Yuan, J; Zhou, Z | 1 |
| Calzavara, MB; Camerini, BA; de Mattos Hungria, F; Ramos, AC; Suiama, MA | 1 |
| da Silva, RP; Eudy, BJ; Fernandez, G; Lai, J; Mathews, CE; McDermott, CE | 1 |
| King, MA; Lewis, MH; Maletz, S; Muehlmann, AM | 1 |
| Ardasheva, A; Biancon, G; Dura, B; Fan, R; Flavell, RA; Fu, X; Gao, Y; Gbyli, R; Halene, S; Iwasaki, A; Joshi, P; Kudo, E; Lee, V; Li, HB; Liu, C; Liu, W; Lobben, K; Nelakanti, R; Song, Y; Tebaldi, T; Teng, R; Vasic, R; Viero, G; Wang, X; Xiao, A | 1 |
| Chao, YM; Hsu, WH; Huang, YJ; Lin, YL; Shiao, YJ | 1 |
| Brusini, R; Cailleau, C; Couvreur, P; Dormont, F; Gaudin, F; Gendron, A; Mougin, J; Peramo, A; Reynaud, F; Varna, M | 1 |
| Pan, YM; Rao, ZQ; Wan, SS; Yang, WJ; Yang, YN | 1 |
| Bissonnette, M; He, C; Huang, H; Lu, TX; Sun, HL; Zhang, L; Zheng, Z | 1 |
| Cui, SX; Doviak, H; Epstein, FH; French, BA; Leor, J; Sano, S; Shah, SA; Walsh, K; Wang, Y; Waters, CD | 1 |
| Alnouti, Y; Bronich, TK; Chen, N; Gautam, N; Jia, Z; Kong, D; Kumar, S; O'Dell, JR; Ren, R; Sun, Y; Thiele, GM; Wang, D; Wang, X; Wei, X; Yang, L; Zhang, F; Zhao, G; Zhao, Z | 1 |
| Bai, X; Liu, P; Zhou, L; Zhu, L | 1 |
| Chang, FC; Fang, CY; Jou, SB; Tsai, CJ; Yi, PL | 1 |
| Bhide, PG; Brown, RW; Gill, WD; Peeters, LD | 1 |
| Castro, CM; Corciulo, C; Coughlin, T; Cronstein, BN; Fenyö, D; Jacob, S; Kennedy, OD; Li, Z; Rifkin, DB | 1 |
| Dai, D; Feng, L; Jin, H; Li, J; Li, L; Shi, R; Song, P; Wang, C; Wang, X; Zhou, Q; Zhu, L | 1 |
| Lin, F; Lu, H; Qian, G; Shen, Z; Sun, Y; Wang, J; Yu, W; Zhang, Z; Zheng, S; Zhou, C; Zhou, Y; Zhu, X | 1 |
| Liebisch, M; Wolf, G | 1 |
| Aasen, T; Abdul Moin, NI; Abdul Wafi, S; Aboukameel, A; Abu-Bakar, N; Acharya, A; Ackermans, L; Adaramoye, O; Adarsh, KV; Adeosun, WA; Ahmad, NH; Ahmadi, F; Akanni, O; Akbar, M; Akbulak, RO; Akev, N; Akkaya, Ö; Al-Rashed, S; AlAbbad, S; Alabi, O; Alappat, BJ; Alcalá, S; Alcoutlabi, M; Aleppo, G; Alexander Ross, JB; Alexander, JH; Alexander, R; Alias, A; Alimba, C; Alken, FA; Allan, R; Alpers, M; Alsbou, EM; Amarasiri, SS; An, T; Anastasiadis, F; Anastassiadou, M; Anderson, KC; Andronikos, P; Anheyer, D; Annapurna, K; Anorlu, RI; Anten, MM; Anthopoulos, TD; Araujo-Castillo, RV; Aravamudhan, S; Arawwawala, LDAM; Arulsamy, N; Arunamata, A; Asghar, A; Asiri, AM; Aslanidou, T; Astrakhantseva, IV; Astutik, E; Attanayake, AP; Atwater, BD; Audureau, E; Augusto, S; Bakare, A; Banach, M; Bandelier, P; Banerjee, S; Barral, M; Bascuñán, J; Bates, FS; Bauer, NJC; Bayrak, BB; Beck, RW; Beckervordersantforth, J; Beeri, R; Begum, R; Beldi-Ferchiou, A; Bellingham, G; Ben-Tal, N; Bendib, I; Bergenstal, RM; Berger, MF; Bernasconi, G; Berry, S; Beuvon, F; Bi, WJ; Bi, Z; Bianconi, V; Bibi, I; Blank, BR; Bliemeister, E; Bobkowski, W; Bode, AM; Booth, CM; Bose, U; Boyd, K; Brancato, A; Brenmoehl, J; Brogi, E; Bronzo, P; Brooks, T; Brown, D; Brown, DN; Bruce, D; Buan, MEM; Bueno-Hernández, F; Bugielski, B; Bulavaitė, A; Buscagan, TM; Buxton, R; Caffaro, MM; Cai, Q; Cai, X; Cai, Y; Calhoun, P; Callander, N; Cambier, S; Camparo, P; Canales-Vargas, EJ; Canham, K; Cantu, J; Cao, J; Cao, JW; Cao, P; Cao, T; Cao, X; Caravella, BA; Carcadea, E; Carè, J; Carmichael, P; Carrasco Cabrera, L; Carteaux, G; Carvalho, PDS; Casarez, E; Cazorla, M; Celestrin, CP; Chakraborty, NK; Chan, B; Chandarlapaty, S; Chandgude, AL; Chang, CC; Chang, JH; Chang, X; Chang, Y; Chankhanittha, T; Chantanis, S; Chapovetsky, A; Chavan, S; Chen, B; Chen, D; Chen, F; Chen, G; Chen, H; Chen, J; Chen, K; Chen, KJ; Chen, KP; Chen, L; Chen, MA; Chen, Q; Chen, S; Chen, W; Chen, WF; Chen, X; Chen, Y; Cheng, D; Cheng, J; Cheng, Q; Cheon, GJ; Chiu, SC; Cho, CH; Cho, J; Choi, H; Choi, JS; Choi, YH; Christie, P; Chu, CH; Chu, Y; Chung, DH; Chung, F; Cline, JP; Cohen, A; Cohen, AD; Cohen, NJ; Comen, E; Compter, I; Cong, J; Cong, Z; Cooper, A; Cornud, F; Costa, C; Costa, S; Covey, A; Cowan, AM; Cramer, H; Cruz-Rivera, C; Cui, J; Cui, M; Cui, Y; Cui, YH; Culquichicón, C; Cushman, T; D'Auria, SJ; da Silva, J; Dalgediene, I; Danenberg, HD; Das, S; Dasgupta, K; Daubit, IM; de Oliveira, PD; de Prost, N; De Ruysscher, D; Dearman, K; Decato, D; Delfau-Larue, MH; Deng, L; Dhakate, SR; Dharuman, V; Di Costanzo, N; Dickler, MN; Dinehart, EE; Ding, D; Dinh, TK; Divya, KP; Djifack Tadongfack, T; Do, T; Domínguez-Roldan, R; Domínguez-Zambrano, E; Dömling, A; Donato, MD; Dong, JH; Dong, W; Dong, X; Dong, XR; Dong, Y; Dong, Z; Downs, M; Drutskaya, MS; Du, B; Du, F; Du, H; Du, L; Du, X; Duan, Z; Duangthip, D; Dunstand-Guzmán, E; Duong, F; Eckert, DJ; Edelhäuser, BAH; Eekers, DBP; Efendi, F; Efraimidis, P; Ehrenberg, H; Ehsanbakhsh, Z; Eickholt, C; Eksterowicz, J; El Mobadder, M; El-Araby, IE; El-Magd, MA; El-Tarabany, MS; Elgorban, AM; Engelmann, D; English, KL; Esfandiari, H; Eslami, B; Espinosa-Cuevas, A; Eswara, S; Faber, E; Fan, XH; Fan, Y; Fang, J; Fang, Z; Fantin, VR; Fei, P; Feng, G; Feng, H; Feng, J; Feng, X; Feng, XJ; Fennell, TR; Fernández-Moreira, V; Ferraz, ABF; Ferreras, KN; Flores, K; Flores-Pérez, I; Flox, C; Fluharty, FL; Fokouong Tchoffo, E; Folefack, GO; Foroutan, T; Fort, D; Fourati, S; Fousas, S; Frapard, T; Freguia, S; Friedman, DJ; Friedman, LS; Fu, D; Fu, Q; Fu, Y; Fujinami, S; Furihata, K; Gal, RL; Gan, H; Gao, C; Gao, F; Gao, R; Gao, SS; Gao, W; Gao, XC; Gao, Y; Gao, Z; Garozi, L; Ge, J; Georgiopoulos, A; Gerakiou, K; Ghazimirsaeed, SM; Ghazimirsaeed, ST; Gimeno, MC; Gjestad, R; Glurich, I; Goetchius, E; Goland, S; Goldstein, S; Gonçalves, CM; Gonçalves, H; Gong, Q; Gonzalez, D; Goplen, FK; Gorshkova, EN; Gotsman, I; Govindasamy, V; Granger, CB; Greco, L; Grigoriadou-Skouta, E; Grigoropoulos, P; Grivicich, I; Gromov, NV; Gruber, S; Grytczuk, M; Grzech-Leśniak, K; Gu, L; Gu, S; Gu, Z; Guadagnini, D; Guan, H; Guilliams, M; Guo, J; Guo, L; Gupta, A; Gupta, SK; Gurzu, S; Gutleb, AC; Haban, A; Hablitz, JJ; Hadisuyatmana, S; Hahn, S; Haiges, R; Hallal-Calleros, C; Hamed, M; Hammad, N; Hammer, N; Han, C; Hao, Y; Harnett, J; Has, EMM; Hassanpour, K; Hatzopoulos, D; Hawaldar, R; He, X; He, Y; He, YY; He, Z; Heberman, D; Heckl, D; Hegde, H; Henson, MA; Hernández-Velázquez, VM; Herrera, E; Hijazi, Z; Hirayama, K; Hirth, JM; Hoeben, A; Hohnloser, SH; Hong, M; Hood, K; Hoplock, LB; Hopman, WM; Horlbogen, LM; Hossein Rashidi, B; Hou, G; Hou, H; Hou, J; Hou, Y; Hu, J; Hu, W; Hu, X; Hua, W; Huang, G; Huang, H; Huang, J; Huang, T; Huang, W; Huang, Y; Huang, YD; Huang, Z; Hudis, CA; Hue, S; Huo, J; Hussain, M; Hvas, AM; Ichii, T; Ide Zeuna, J; Ilyas, S; Inoue, T; Iranzo, A; Irfan, M; Iwasa, Y; Iwashita, Y; Izgorodina, EI; J R, A; Jaber, WA; Jaborek, JR; Jacobus, SJ; Jadeja, SD; Jafarabadi, M; Jalan, D; Jamil, MI; Jarrah, S; Jarvis, D; Jayatilaka, KAPW; Jemal-Turki, A; Jeon, YK; Jeong, N; Jeong, SH; Jeong, SY; Jermy, M; Jhaveri, K; Ji, H; Ji, K; Ji, RY; Jiang, F; Jiang, J; Jiang, X; Jiang, Y; Jiao, Q; Jilani, K; Jiménez-Guerrero, P; Jin, L; Jo, YH; Johnson, JG; Johnson, ML; Jones, WS; Jose, S; Jularic, M; Jung, I; Jung, YJ; Jungen, C; Junttila, MR; Kache, S; Kahanovitch, U; Kalantzi, KI; Kallio, T; Kamnoedboon, P; Kang, CH; Kang, H; Kang, J; Kang, KW; Kapoor, P; Karmakar, D; Kartalis, A; Kauranen, P; Kazocina, A; Keikha, F; Keltai, M; Kershaw, SV; Kettani, M; Khalvati, S; Khandhar, S; Khosla, N; Kiely, CJ; Kim, CC; Kim, H; Kim, MJ; Kim, Y; Kim, YH; Kim, YT; Kimoto, E; Kiyu, A; Klatt, N; Kobayashi, M; Koh, J; Köhler, R; Kondadasula, SV; Kong, H; Kong, W; Kong, X; Kotidis, A; Kotwal, A; Kouvari, M; Kozhinov, AN; Kruger, D; Kuang, S; Kuang, Y; Kubota, M; Kuklik, P; Kumar, P; Kumar, SK; Kuo, YF; Kurup, SP; Kusuhara, H; Kuswanto, H; Lacouture, ME; Lambin, P; Lang, CC; Langroudi, FH; Lanman, RB; Larsen, OH; Laskin, J; Le, VH; Leach, M; Lee, BG; Lee, DF; Lee, DS; Lee, HJ; Lee, SB; Lee, YA; Lei, Y; Lekashvili, O; Lelj, F; Lemin, AS; Lemoine, J; Leuschner, R; Li, B; Li, BT; Li, C; Li, D; Li, F; Li, G; Li, H; Li, HW; Li, J; Li, M; Li, P; Li, Q; Li, S; Li, W; Li, X; Li, XY; Li, Y; Li, Z; Lian, Y; Liang, C; Liao, J; Liao, W; Liao, Y; Lin, D; Lin, W; Lin, YL; Lindbäck, J; Lindsay, AP; Ling, J; Linser, PJ; Liu, C; Liu, H; Liu, JJ; Liu, L; Liu, Q; Liu, SF; Liu, X; Liu, Y; Liu, Z; Liu, ZM; Lo Sterzo, C; Lo, ECM; Lobchuk, MM; Lodge, TP; Logotheti, S; Lonial, S; Lopes, G; Lopes, RD; Lopez, J; Lopez, SA; López-Santos, AL; López-Sendón, JL; Loring, Z; Louis, C; Lovita, AND; Lu, DZ; Lu, H; Lu, J; Lu, K; Lu, TT; Lu, Y; Luengo, A; Lum, LG; Luna, JM; Luo, L; Luo, R; Luo, T; Luo, X; Luo, Z; Lv, B; Lymperopoulos, N; Lyras, A; Lyu, Y; M Kannan, A; Ma, H; Ma, M; Ma, Q; Ma, S; Ma, WY; Ma, Y; Maalouf, E; Machado, FA; Maeda, K; Magrans, JO; Maharani, A; Maia, G; Mainwaring, RD; Maji, TK; Majumdar, K; Mannarino, MR; 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| Braun, OÖ; Gustafsson, D; Rahman, M; Thorlacius, H; Wang, Y | 1 |
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| Baloch, E; Bamberg, F; Ebersberger, U; Hetterich, H; Hildebrandt, K; Hinkel, R; Hoffmann, U; Kupatt, C; Marcus, RP; Nikolaou, K; Reiser, MF; Sandner, TA; Schlett, CL; Schwarz, F; Theisen, D | 1 |
| Babu, YS; Bantia, S; Bavari, S; Chen, X; Dong, L; Eaton, BP; Garza, NL; Honnold, S; Kotian, P; Minning, DM; Panchal, RG; Pegoraro, G; Retterer, CJ; Sheridan, WP; Stuthman, KS; Taubenheim, BR; Van Tongeren, SA; Warren, TK; Welch, LS; Wells, J | 1 |
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| Busuttil, RW; Gao, F; He, X; Ji, H; Kuchroo, VK; Kupiec-Weglinski, JW; Li, GA; Liu, Y; Shen, X; Zhang, Y | 1 |
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| Andrews, K; Brown, M; Cardozo, M; Chen, Y; Cushing, TD; Duquette, J; Fisher, B; Gonzalez-Lopez de Turiso, F; Hao, X; He, X; Henne, KR; Hu, YL; Hungate, R; Johnson, MG; Kelly, RC; Lucas, B; McCarter, JD; McGee, LR; Medina, JC; Metz, DP; Mohn, D; Pattaropong, V; Pettus, LH; Reichelt, A; Rzasa, RM; San Miguel, T; Seganish, J; Shin, Y; Tasker, AS; Wahl, RC; Wannberg, S; Whittington, DA; Whoriskey, J; Yu, G; Zalameda, L; Zhang, D | 1 |
| Adam, R; Bejaoui, M; Ben Abdennebi, H; Calvo, M; Folch-Puy, E; Pantazi, E; Pasut, G; Rimola, A; Roselló-Catafau, J; Zaouali, MA | 1 |
| Cheng, X; Gong, X; Kuang, G; Min, S; Wan, J; Wang, B | 1 |
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| Bouchareb, R; Boulanger, MC; Hadji, F; Mahmut, A; Mathieu, P | 1 |
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| French, BA; Linden, J; Marshall, M; Tian, Y; Yang, Z | 1 |
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| Cen, J; Feng, X; He, Y; Qiu, Y; Ren, T; Tian, T; Wang, H; Wu, W; Ye, S; Yu, C; Zeng, J; Zhou, Y | 1 |
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| Castonguay, A; Chen, Z; Cottet, M; De Koninck, Y; Doyle, T; Egan, TM; Ford, A; Jacobson, KA; Little, JW; Salvemini, D; Symons-Liguori, AM; Tosh, DK; Vanderah, TW | 1 |
| Alessandrini, F; Behrendt, H; Ernst, D; Ferreira, F; Frank, U; Gilles, S; Gutermuth, J; Hauser, M; Oeder, S; Ohnmacht, C; Ring, J; Schmidt-Weber, C; Schmitt-Kopplin, P; Traidl-Hoffmann, C; Wimmer, M; Winkler, JB | 1 |
| Cronstein, BN; Desai-Merchant, A; Montesinos, MC | 1 |
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| Alexander, MP; Chabanet, TB; Clancy-Thompson, E; Croteau, W; Huang, YH; Mullins, DW; Perekslis, TJ; Turk, MJ | 1 |
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| Blackburn, MR; Chen, NY; Davies, J; Eltzschig, HK; Karmouty-Quintana, H; Le, NB; Liu, H; Luo, F; Mills, T; Molina, JG; Philip, K; Volcik, KA; Xia, Y | 1 |
| Gong, ZH; Huang, B; Jia, YX; Su, RB; Wang, ML; Wang, ZT; Yi, SP; Yu, G; Zhang, FY | 1 |
| Cobelens, H; Koehn, D; Kooi, ME; Munts, C; Post, MJ; Slenter, J; Strijkers, GJ; van Bilsen, M; van Haare, J; van Teeffelen, JW; Vink, H | 1 |
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| Aktas, O; Bauer, A; Graf, J; Hartung, HP; Hofrichter, M; Ingwersen, J; Lepka, K; Prozorovski, T; Schrader, J; Schröter, F; Wedekind, F; Wingerath, B | 1 |
| Blackburn, MR; Cappuccini, F; Chen, NY; de Leve, S; Eldh, T; Fischer, U; Gau, E; Jendrossek, V; Karmouty-Quintana, H; Kasper, M; Klein, D; Meyer, AV; Ritchey, JW; Stuschke, M; Thompson, LF; Westendorf, AM; Wirsdörfer, F | 1 |
| Kumei, S; Miyagishi, S; Nozu, T; Ohhira, M; Okumura, T; Takakusaki, K | 1 |
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| Chen, H; Duan, RS; Li, H; Li, XL; Wang, CC; Wang, S; Xu, H; Yang, B; Yue, LT; Zhang, M; Zhang, P | 1 |
| Hagisawa, K; Handa, M; Iwaya, K; Kinoshita, M; Miyawaki, H; Miyazaki, H; Nishida, Y; Saitoh, D; Sato, S; Seki, S; Shono, S; Suzuki, H; Takeoka, S | 1 |
| Anyanwu, AC; Burant, CF; Goonewardena, SN; Hyman, MC; Kanthi, Y; Petrovic-Djergovic, D; Pinsky, DJ; Rattan, R; Robichaud, P; Visovatti, SH; Wang, J | 1 |
| Faingold, CL; Kommajosyula, SP; Randall, M | 1 |
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| Bertorelli, R; Bianchi, L; Corsi, C; Melani, A; Monopoli, A; Pantoni, L; Pedata, F; Pepeu, G | 1 |
| Kitamura, Y; Matsuoka, Y; Ohta, S; Okazaki, M; Sekino, Y; Takata, K; Taniguchi, T | 1 |
| Guyton, RA; Nakamura, M; Shearer, S; Vinten-Johansen, J; Wang, NP; Wilcox, JN; Zhao, ZQ | 1 |
| Aebischer, P; Boison, D; Mohler, H; Scheurer, L; Tseng, JL | 1 |
| Lutty, GA; McLeod, DS; Merges, C | 1 |
| Chiba, Y; Ihaya, A; Muraoka, R; Nara, M; Niwa, H; Uesaka, T | 1 |
| Behringer, W; Hans, R; Jackson, EK; Kochanek, P; Prueckner, S; Radovsky, A; Safar, P; Stezoski, SW; Takasu, A; Tisherman, SA; Woods, RJ | 1 |
| Angelatou, F; Ekonomou, A; Kostopoulos, G; Sperk, G | 1 |
| Aldrich, MB; Blackburn, MR; Kellems, RE | 1 |
| Borowicz, KK; Czuczwar, SJ; Kleinrok, Z | 1 |
| Fisher, MJ; Gaughen, JR; Kallmes, DF; Kern, JA; Kron, IL; Parrino, PE; Ross, SD; Shockey, KS; Tribble, CG | 1 |
| Aldrich, M; Blackburn, MR; Chen, W; Datta, SK; Hershfield, MS; Kellems, RE; Kelly, S; Volmer, JB; Zhong, H | 1 |
| Aden, U; Berman, RF; Fredholm, BB; O'Connor, WT | 1 |
| Fozard, JR; Hannon, JP | 1 |
| Camp, DM; Harel, E; Juneau, PL; LeWitt, PA; Loeffler, DA | 1 |
| Hirohashi, K; Inoue, M; Kinoshita, H; Minamiyama, Y; Nakamura, A; Sakata, C; Takemura, S; Tanaka, H | 1 |
| Bartling, C; Hamann, M; Richter, A | 1 |
| Ferré, S; Fuxe, K; Müller, CE; Popoli, P; Strömberg, I | 1 |
| Fukuda, T; Iwata, S; Kaseda, S; Nakagawa, S; Nomoto, M; Shimizu, T | 1 |
| Di Gregorio, V; Levitsky, S; McCully, JD; Parker, RA; Toyoda, Y | 1 |
| Davis, KA; Fabian, TC; Proctor, KG; Ragsdale, DN; Trenthem, LL | 1 |
| Akgür, FM; Brown, MF; Granger, DN; Howell, JG; McDonald, JC; Olinde, JG; Zibari, GB | 1 |
| Proctor, KG; Ragsdale, DN | 1 |
| Kloner, RA; Przyklenk, K | 1 |
| Dubey, R; Gillespie, DG; Jackson, EK; Mi, Z | 1 |
| Hasebe, N; Ido, A; Kikuchi, K; Matsuhashi, H | 1 |
| Chung, ES; Dobson, JG; Fenton, RA; Lorbar, M; Meyer, TE; Norton, GR; Perlini, S; Woodiwiss, AJ | 1 |
| Flores, NA; Kingsbury, MP; Robinson, H; Sheridan, DJ | 1 |
| Al-Awadi, FM; Khan, I | 1 |
| Araki, T; Murata, T; Power, GG; Sawa, R; Suzuki, S; Yoneyama, Y | 1 |
| Bjerner, T; Henze, A; Ronquist, G; Thelin, S; Waldenström, A; Wikström, G; Zemgulis, V | 1 |
| Chen, M; Kabir, K; Luo, X; Rabinovici, R; Su, Y; Yang, JH; Zhang, D | 1 |
| Ates, N; Ilbay, G; Karson, A; Sahin, D | 1 |
| Cassada, DC; Fiser, SM; Kaza, AK; Kern, JA; Kron, IL; Linden, J; Long, SM; Rieger, JM; Tribble, CG | 1 |
| Hamann, M; Richter, A | 1 |
| Cheng, JT; Chi, TC; Liu, IM | 1 |
| Feldbaum, VM; Huang, J; Lucchesi, BR; Werns, SW | 1 |
| Fisher, NG; Kaul, S; Leong-Poi, H; Lindner, JR; Rim, SJ; Wei, K | 1 |
| Minabe, Y; Muneoka, KT; Shirayama, Y; Takigawa, M | 1 |
| Aldrich, MB; Blackburn, MR; Datta, SK; Kellems, RE | 1 |
| Hou, T; Li, M; Li, Z; Wang, Q; Zhang, L; Zhang, Q; Zhao, J | 1 |
| Iwamoto, T; Miki, S; Noguchi, K; Okamoto, K; Sato, S; Senba, E; Yasuda, T; Yoshinaga, N | 1 |
| Canty, JM; Fallavollita, JA | 1 |
| Delabar, U; Kloor, D; Luippold, G; Mühlbauer, B; Osswald, H | 1 |
| Gotoh, L; Hirano, M; Hondo, H; Kanchiku, I; Kawanami, N; Kuroki, T; Motomura, K; Nakahara, T; Ohta, E; Uchimura, H | 1 |
| Alberti, C; Casati, C; Monopoli, A; Morganti, A; Ongini, E; Sala, C; Zanchetti, A | 1 |
| Kay, MA; Lancaster, AM; Lukavsky, PJ; McCaffrey, AP; Meuse, L; Ohashi, K; Sarnow, P; Shen, S | 1 |
| Chaudhary, G; Gupta, YK; Srivastava, AK | 1 |
| Berdeaux, A; Bruneval, P; Ghaleh, B; Giudicelli, JF; Souktani, R; Tissier, R | 1 |
| Baker, RO; Bray, M; Geisbert, T; Raymond, JL | 1 |
| Chan, ES; Cronstein, BN | 1 |
| Buja, LM; Fink, GS; Mukherjee, A; Platt, M; Scales, F; Templeton, GH; Willerson, JT | 1 |
| Bashour, FA; Boutros, IS; Downey, HF; Parker, PE | 1 |
| De Jong, JW; Stam, H | 1 |
| Cohen, MV; Kirk, ES; Sonnenblick, EH | 1 |
| Olsson, RA | 1 |
| Gerlach, E; Haddy, FJ; Schrader, J | 1 |
| Abrams, TA; Gregory, CY; Hall, MO | 1 |
| Franklin, PH; Murray, TF; Tripp, E; Zhang, G | 1 |
| Aaron, AM; Boyers, AS; Burnham, KM; Eisner, RL; Leon, AR; Martin, SE; Oh, DJ; Patterson, RE; Schmarkey, LS | 1 |
| Hori, M; Inoue, M; Iwai, K; Kamada, T; Kitabatake, A; Kitakaze, M; Sato, H; Takashima, S | 1 |
| Baron, C; Hasni, H; Laborit, G; Laborit, H; Pierrefiche, G | 1 |
| Rush, W; Sidi, A | 1 |
| Scheidegger, D; von Planta, I; von Planta, M; Wagner, O | 1 |
| Karasawa, A; Lefer, AM; Rochester, JA | 1 |
| Burnham, WM; Mingo, NS | 1 |
| Eliseev, VV; Katkov, VF; Nagornev, SN; Poltavchenko, GM | 1 |
| Duncker, DJ; Gornick, C; Krams, R; McFalls, EO; Verdouw, PD; Ward, H | 1 |
| Belkina, LM; Evsev'eva, ME; Meerson, FZ; Obol'nikova, EA; Pozdniakov, OM; Samokhvalov, GI; Slobodianik, VV; Vovk, VI | 1 |
| Forman, MB; Jackson, EK; Norton, ED; Virmani, R | 1 |
| Hartman, JC; Kampine, JP; Schmeling, WT; Warltier, DC | 1 |
| Avila, JL; Convit, J; Monzón, H; Rojas, T | 1 |
| Arruzazabala, ML; Garcia, M | 1 |
| Bacher, J; Klein, E; Marangos, PJ; Montgomery, P; Uhde, TW | 1 |
| Paul, SM; Wolkowitz, OM | 1 |
| Cohen, MV | 1 |
| Kulkarni, SK; Mehta, AK | 1 |
| Feit, C; Roche, M | 1 |
| Kranzhöfer, R; Mayer, E; Richardt, G; Schömig, A; Waas, W | 1 |
| Pauwels, RA; Van der Straeten, ME | 1 |
| Kreutzberg, GW; Lee, KS; Tetzlaff, W | 1 |
| Leppo, JA; Okada, RD; Pohost, GM; Strauss, HW | 1 |
| Abboud, FM; Armstrong, ML; Heistad, DD; Marcus, ML | 1 |
| Albini, B; Sundick, RS; Wick, G | 1 |
| Cox, RP; Deutsch, SI; Ghosh, NK; Romano, TJ | 1 |
| Kraupp, O; Raberger, G; Weissel, M | 1 |
| Ljunggren, B; Schutz, H; Siesjö, BK | 1 |
| Ljunggren, B; Ratcheson, RA; Siesjö, BK | 1 |
50 review(s) available for adenosine and Disease Models, Animal
| Article | Year |
|---|---|
The Pathophysiology and Treatment of Essential Tremor: The Role of Adenosine and Dopamine Receptors in Animal Models.
Topics: Adenosine; Animals; Disease Models, Animal; Essential Tremor; Humans; Quality of Life; Receptor, Adenosine A1; Receptors, Dopamine | 2021 |
Mechanistic considerations for adenosine-lidocaine-magnesium (ALM) in controlling coagulopathy.
Topics: Adenosine; Animals; Disease Models, Animal; Humans; Lidocaine; Magnesium; Shock, Hemorrhagic; Swine | 2023 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acrylic Resins; Actinobacillus; Acute Disease; Acute Kidney Injury; Adaptor Proteins, Signal Transducing; Adenosine; Adenosine Triphosphate; Administration, Inhalation; Administration, Oral; Adolescent; Adult; Advance Care Planning; Africa, Northern; Age Factors; Aged; Aged, 80 and over; Air Pollutants; Air Pollution; Air Pollution, Indoor; Albendazole; Aluminum Oxide; Anastomosis, Surgical; Ancylostoma; Ancylostomiasis; Androstadienes; Angiogenesis Inhibitors; Angiotensin II; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antibodies, Bispecific; Antibodies, Viral; Anticoagulants; Antihypertensive Agents; Antinematodal Agents; Antineoplastic Agents; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antiporters; Antiviral Agents; Apoptosis; Aptamers, Nucleotide; Aromatase Inhibitors; Asian People; Astrocytes; Atrial Fibrillation; Auditory Threshold; Aurora Kinase B; Australia; Autophagy; Autophagy-Related Protein 5; Autotrophic Processes; Bacillus cereus; Bacillus thuringiensis; Bacterial Proteins; Beclin-1; Belgium; Benzene; Benzene Derivatives; Benzhydryl Compounds; beta Catenin; beta-Arrestin 2; Biliary Tract Diseases; Biofilms; Biofuels; Biomarkers; Biomarkers, Tumor; Biomass; Biomechanical Phenomena; Bioreactors; Biosensing Techniques; Biosynthetic Pathways; Bismuth; Blood Platelets; Bone and Bones; Bone Regeneration; Bortezomib; Botulinum Toxins, Type A; Brain; Brain Injuries; Brain Ischemia; Brain Neoplasms; Breast Neoplasms; Breath Tests; Bronchodilator Agents; Calcium Phosphates; Cannabis; Carbon Dioxide; Carbon Isotopes; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cardiac Resynchronization Therapy; Cardiac Resynchronization Therapy Devices; Cardiomyopathies; Cardiovascular Diseases; Cariostatic Agents; Case Managers; Case-Control Studies; Catalysis; Cation Transport Proteins; CD8-Positive T-Lymphocytes; Cecropia Plant; Cell Adhesion; Cell Count; Cell Differentiation; Cell Division; Cell Line; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Cell Self Renewal; Cell Survival; Cells, Cultured; Cellular Reprogramming; Cellulose; Charcoal; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemokines; Chemoradiotherapy; Chemoreceptor Cells; Child; Child Abuse; Child, Preschool; China; Chlorogenic Acid; Chloroquine; Chromatography, Gas; Chronic Disease; Clinical Competence; Coated Materials, Biocompatible; Cochlea; Cohort Studies; Color; Comorbidity; Computer Simulation; Computer-Aided Design; Contraception; Contraceptive Agents, Female; Contrast Media; COP-Coated Vesicles; Coronavirus Infections; Cost of Illness; Coturnix; COVID-19; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Culex; Curriculum; Cyclic N-Oxides; Cytokines; Cytoplasm; Cytotoxicity, Immunologic; Cytotoxins; Databases, Factual; Deep Learning; Delivery, Obstetric; Denitrification; Dental Caries; Denture, Complete; Dexamethasone; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dielectric Spectroscopy; Diet, High-Fat; Dietary Fiber; Disease Models, Animal; Disease Progression; DNA; DNA Copy Number Variations; DNA, Mitochondrial; Dog Diseases; Dogs; Dopaminergic Neurons; Double-Blind Method; Down-Regulation; Doxorubicin; Drug Carriers; Drug Design; Drug Interactions; Drug Resistance, Bacterial; Drug Resistance, Neoplasm; Drug-Related Side Effects and Adverse Reactions; Drugs, Chinese Herbal; Dry Powder Inhalers; Dust; E2F1 Transcription Factor; Ecosystem; Education, Nursing; Education, Nursing, Baccalaureate; Electric Impedance; Electricity; Electrocardiography; Electrochemical Techniques; Electrochemistry; Electrodes; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Endothelial Cells; Environmental Monitoring; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Estrogen Receptor Modulators; Europe; Evoked Potentials, Auditory, Brain Stem; Exosomes; Feasibility Studies; Female; Ferricyanides; Ferrocyanides; Fibrinogen; Finite Element Analysis; Fistula; Fluorescent Dyes; Fluorides, Topical; Fluorodeoxyglucose F18; Fluticasone; Follow-Up Studies; Food Contamination; Food Microbiology; Foods, Specialized; Forensic Medicine; Frail Elderly; France; Free Radicals; Fresh Water; Fungi; Fungicides, Industrial; Galactosamine; Gastrointestinal Neoplasms; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Frequency; Genetic Predisposition to Disease; Genotype; Gingival Hemorrhage; Glioblastoma; Glioma; Glomerular Filtration Rate; Glomerulosclerosis, Focal Segmental; Glucose; Glucose Transport Proteins, Facilitative; Glucosides; Glutamine; Glycolysis; Gold; GPI-Linked Proteins; Gram-Negative Bacteria; Gram-Positive Bacteria; Graphite; Haplotypes; HCT116 Cells; Healthy Volunteers; Hearing Loss; Heart Failure; Hedgehog Proteins; HEK293 Cells; HeLa Cells; Hemodynamics; Hemorrhage; Hepatocytes; Hippo Signaling Pathway; Histone Deacetylases; Homeostasis; Hospital Mortality; Hospitalization; Humans; Hydantoins; Hydrazines; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Hydroxylamines; Hypoglycemic Agents; Immunity, Innate; Immunoglobulin G; Immunohistochemistry; Immunologic Factors; Immunomodulation; Immunophenotyping; Immunotherapy; Incidence; Indazoles; Indonesia; Infant; Infant, Newborn; Infarction, Middle Cerebral Artery; Inflammation; Injections, Intramuscular; Insecticides; Insulin-Like Growth Factor I; Insurance, Health; Intention to Treat Analysis; Interleukin-1 Receptor-Associated Kinases; Interleukin-6; Intrauterine Devices; Intrauterine Devices, Copper; Iron; Ischemia; Jordan; Keratinocytes; Kidney; Kidney Diseases; Kir5.1 Channel; Klebsiella Infections; Klebsiella pneumoniae; Lab-On-A-Chip Devices; Laparoscopy; Lasers; Lasers, Semiconductor; Lenalidomide; Leptin; Lethal Dose 50; Levonorgestrel; Limit of Detection; Lipid Metabolism; Lipid Metabolism Disorders; Lipogenesis; Lipopolysaccharides; Liquid Biopsy; Liver; Liver Abscess, Pyogenic; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Longevity; Lung Neoplasms; Luteolin; Lymph Nodes; Lymphocyte Activation; Macaca fascicularis; Macrophages; Mad2 Proteins; Magnetic Resonance Imaging; Male; Mammary Glands, Human; Manganese; Manganese Compounds; MAP Kinase Signaling System; Materials Testing; Maternal Health Services; MCF-7 Cells; Medicaid; Medicine, Chinese Traditional; Melanoma; Membrane Proteins; Mental Health; Mercury; Metal Nanoparticles; Metals, Heavy; Metformin; Methionine Adenosyltransferase; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Mice, Nude; Microalgae; Microbial Sensitivity Tests; Microglia; MicroRNAs; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Middle Aged; Mitochondria; Mitochondrial Proteins; Mitral Valve; Mitral Valve Insufficiency; Models, Anatomic; Molecular Structure; Molybdenum; Monocarboxylic Acid Transporters; Moths; MPTP Poisoning; Multigene Family; Multiparametric Magnetic Resonance Imaging; Multiple Myeloma; Muscle, Skeletal; Mutagens; Mutation; Myeloid Cells; Nanocomposites; Nanofibers; Nanomedicine; Nanoparticles; Nanowires; Neoadjuvant Therapy; Neomycin; Neoplasm Grading; Neoplasm Recurrence, Local; Neoplasms; Neoplastic Stem Cells; Neostriatum; Neovascularization, Pathologic; Netherlands; Neuromuscular Agents; Neurons; NF-E2-Related Factor 2; NF-kappa B; Nickel; Nitrogen Oxides; Non-alcoholic Fatty Liver Disease; Nucleosides; Nucleotidyltransferases; Nutritional Status; Obesity, Morbid; Ofloxacin; Oils, Volatile; Oligopeptides; Oncogene Protein v-akt; Optical Imaging; Organic Cation Transport Proteins; Organophosphonates; Osteoarthritis; Osteoarthritis, Hip; Osteoarthritis, Knee; Osteoblasts; Osteogenesis; Oxidation-Reduction; Oxidative Stress; Oxides; Oxygen Isotopes; Pancreas; Pancreaticoduodenectomy; Pandemics; Particle Size; Particulate Matter; Patient Acceptance of Health Care; Patient Compliance; PC-3 Cells; Peptide Fragments; Peptides; Periodontal Attachment Loss; Periodontal Index; Periodontal Pocket; Periodontitis; Peroxides; Peru; Pest Control, Biological; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Phylogeny; Pilot Projects; Piperidines; Plant Bark; Plant Extracts; Plant Leaves; Plasmids; Platelet Function Tests; Pneumonia, Viral; Podocytes; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Polyethylene Terephthalates; Polymers; Polymorphism, Single Nucleotide; Porosity; Portugal; Positron-Emission Tomography; Postoperative Complications; Postural Balance; Potassium Channels, Inwardly Rectifying; Povidone; Powders; Precancerous Conditions; Precision Medicine; Predictive Value of Tests; Pregnancy; Prenatal Care; Prognosis; Promoter Regions, Genetic; Prospective Studies; Prostatectomy; Prostatic Neoplasms; Proteasome Inhibitors; Protective Agents; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; Psychiatric Nursing; PTEN Phosphohydrolase; Pulmonary Embolism; Pyrimethamine; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reactive Oxygen Species; Receptor, ErbB-2; Receptor, IGF Type 1; Receptors, Estrogen; Receptors, G-Protein-Coupled; Recombinational DNA Repair; Recovery of Function; Regional Blood Flow; Renal Dialysis; Renin; Renin-Angiotensin System; Reperfusion Injury; Reproducibility of Results; Republic of Korea; Respiratory Distress Syndrome; Retrospective Studies; Rhodamines; Risk Assessment; Risk Factors; RNA, Long Noncoding; RNA, Messenger; Running; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salinity; Salmeterol Xinafoate; Sarcoma; Seasons; Shoulder Injuries; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Sirtuins; Skull Fractures; Social Determinants of Health; Sodium; Sodium Fluoride; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Glucose Transporter 2 Inhibitors; Soil; Soil Pollutants; Spain; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Staphylococcal Protein A; Staphylococcus aureus; Stem Cells; Stereoisomerism; Stomach Neoplasms; Streptomyces; Strontium; Structure-Activity Relationship; Students, Nursing; Substance-Related Disorders; Succinic Acid; Sulfur; Surface Properties; Survival Rate; Survivin; Symporters; T-Lymphocytes; Temozolomide; Tensile Strength; Thiazoles; Thiobacillus; Thiohydantoins; Thiourea; Thrombectomy; Time Factors; Titanium; Tobacco Mosaic Virus; Tobacco Use Disorder; Toll-Like Receptor 4; Toluene; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Toxicity Tests, Acute; Toxicity Tests, Subacute; Transcriptional Activation; Treatment Outcome; Troponin I; Tumor Cells, Cultured; Tumor Escape; Tumor Hypoxia; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Tyrosine; Ubiquitin-Protein Ligases; Ubiquitination; Ultrasonic Waves; United Kingdom; United States; United States Department of Veterans Affairs; Up-Regulation; Urea; Uric Acid; Urinary Bladder Neoplasms; Urinary Bladder, Neurogenic; Urine; Urodynamics; User-Computer Interface; Vemurafenib; Verbenaceae; Veterans; Veterans Health; Viral Load; Virtual Reality; Vitiligo; Water Pollutants, Chemical; Wildfires; Wnt Signaling Pathway; Wound Healing; X-Ray Diffraction; Xenograft Model Antitumor Assays; Xylenes; Young Adult; Zinc; Zinc Oxide; Zinc Sulfate; Zoonoses | 2021 |
Surmounting cancer drug resistance: New insights from the perspective of N
Topics: Adenosine; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Disease Models, Animal; DNA Damage; DNA Repair; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Immune Checkpoint Inhibitors; Methylation; Neoplasms; Protein Kinase Inhibitors; RNA Processing, Post-Transcriptional; Treatment Outcome; Tumor Microenvironment | 2020 |
Do caffeine and more selective adenosine A
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Disease Models, Animal; Humans; Neuroprotective Agents; Parkinson Disease; Receptor, Adenosine A2A | 2020 |
Extracellular ATP and Adenosine in Cancer Pathogenesis and Treatment.
Topics: Adenosine; Adenosine Triphosphate; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Clinical Trials as Topic; Disease Models, Animal; Drug Resistance, Neoplasm; Humans; Immune Checkpoint Inhibitors; Neoplasms; Progression-Free Survival; Purinergic P1 Receptor Antagonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P1; Receptors, Purinergic P2; Signal Transduction; Xenograft Model Antitumor Assays | 2021 |
Connection between γδ T-cell- and Adenosine- Mediated Immune Regulation in the Pathogenesis of Experimental Autoimmune Uveitis.
Topics: Adenosine; Animals; Autoimmune Diseases; Disease Models, Animal; Humans; Mice; Models, Animal; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocytes, Regulatory; Th1 Cells; Th17 Cells; Uveitis | 2018 |
CD73 (Cluster of Differentiation 73) and the Differences Between Mice and Humans.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Monophosphate; Animals; Clinical Trials as Topic; Disease Models, Animal; GPI-Linked Proteins; Humans; Inflammation; Joint Diseases; Mice, Knockout; Molecular Targeted Therapy; Neoplasms; Phenotype; Species Specificity; Thrombophilia; Tunica Media; Vascular Calcification; Vascular Diseases; Vascular Remodeling | 2019 |
Suitability of the adenosine antagonist istradefylline for the treatment of Parkinson's disease: pharmacokinetic and clinical considerations.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Blood-Brain Barrier; Disease Models, Animal; Dopamine Agonists; Dyskinesias; Half-Life; Humans; Levodopa; Parkinson Disease; Purines; Treatment Outcome | 2013 |
Pathophysiology of coronary collaterals.
Topics: Adenosine; Animals; Collateral Circulation; Coronary Circulation; Coronary Disease; Coronary Vessels; Disease Models, Animal; Exercise; Humans; Myocardial Ischemia; Percutaneous Coronary Intervention; Stress, Physiological; Vascular Resistance; Vasodilator Agents; Vasomotor System; Ventricular Dysfunction, Left | 2014 |
Purinergic receptors in psychiatric disorders.
Topics: Adenosine; Adenosine Triphosphate; Animals; Brain; Depressive Disorder, Major; Disease Models, Animal; Humans; Mental Disorders; Receptors, Purinergic; Schizophrenia; Signal Transduction | 2016 |
Role of T-cells in myocardial infarction.
Topics: Acute Coronary Syndrome; Adaptive Immunity; Adenosine; Animals; Cell Movement; Disease Models, Animal; Humans; Immunity, Innate; Lymphocyte Activation; Mice; Myocardial Infarction; Myocardial Reperfusion Injury; Signal Transduction; T-Lymphocytes | 2016 |
[Adenosine deaminase in experimental trypanosomiasis: future implications].
Topics: Adenosine; Adenosine Deaminase; Animals; Disease Models, Animal; Humans; Inflammation Mediators; Trypanosoma; Trypanosomiasis | 2015 |
Progress in Therapies for Myocardial Ischemia Reperfusion Injury.
Topics: Adenosine; Animals; Atrial Natriuretic Factor; Clinical Trials as Topic; Combined Modality Therapy; Cyclosporine; Disease Models, Animal; Exenatide; Humans; Ischemic Postconditioning; Ischemic Preconditioning; Myocardial Ischemia; Myocardial Reperfusion Injury; Peptides; Venoms | 2017 |
Potential role of adenosine A2A receptors in the treatment of schizophrenia.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Cognition; Disease Models, Animal; Dopamine; Humans; Receptor Cross-Talk; Receptors, Dopamine; Receptors, Glutamate; Schizophrenia | 2008 |
Dopamine/adenosine interactions related to locomotion and tremor in animal models: possible relevance to parkinsonism.
Topics: Adenosine; Animals; Disease Models, Animal; Dopamine; Humans; Locomotion; Parkinson Disease; Tremor | 2008 |
Adenosine signaling and the regulation of chronic lung disease.
Topics: Acute Disease; Adenosine; Adenosine Deaminase; Animals; Chronic Disease; Disease Models, Animal; Humans; Lung Diseases, Interstitial; Lung Diseases, Obstructive; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Signal Transduction | 2009 |
Signaling pathways of cardioprotective ischemic preconditioning.
Topics: Acetylcholine; Adenosine; Angioplasty, Balloon, Coronary; Animals; Bradykinin; Coronary Circulation; Disease Models, Animal; Humans; Ischemic Preconditioning, Myocardial; Myocardial Infarction; Myocardial Reperfusion Injury; Primary Prevention; Prognosis; Prospective Studies; Protein Kinases; Radiography; Reactive Oxygen Species; Risk Assessment; Signal Transduction | 2009 |
The antihypoxia-adenosinergic pathogenesis as a result of collateral damage by overactive immune cells.
Topics: Acute Lung Injury; Adenosine; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Disease Models, Animal; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Mice; Mice, Mutant Strains; Oxygen; Oxygen Consumption; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Respiratory Distress Syndrome; T-Lymphocytes, Regulatory | 2009 |
Biochemical and anatomical substrates of depression and sickness behavior.
Topics: Adenosine; Adrenergic Uptake Inhibitors; Animals; Basal Ganglia; Brain; Depression; Disease Models, Animal; Dopamine; gamma-Aminobutyric Acid; Illness Behavior; Interleukin-1; Lipopolysaccharides; Neurons; Receptor, Adenosine A2A; Receptors, Dopamine D2; Reserpine; Signal Transduction | 2010 |
Adenosine dysfunction in epilepsy.
Topics: Adenosine; Adenosine Kinase; Animals; Disease Models, Animal; Epilepsy; Humans; Metabolic Diseases; Phosphorylation | 2012 |
Endothelium-targeted pharmacotherapeutics for the treatment of stroke.
Topics: Adenosine; Animals; Brain Ischemia; Clinical Trials as Topic; Disease Models, Animal; Endothelium, Vascular; Free Radical Scavengers; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Matrix Metalloproteinase Inhibitors; Serotonin Antagonists; Stroke; Vasodilator Agents | 2002 |
Classical and alternative pathways of mast cell activation.
Topics: Adenosine; Animals; Cell Degranulation; Disease Models, Animal; Endothelin-1; Gene Expression Regulation; Immune System; Immunoglobulin G; Infections; Inflammation; Mast Cells; Neurosecretory Systems; Receptors, IgE | 2002 |
Retinal vascular development and oxygen-induced retinopathy: a role for adenosine.
Topics: Adenosine; Animals; Animals, Newborn; Disease Models, Animal; Dogs; Endothelial Growth Factors; Humans; Infant, Newborn; Intercellular Signaling Peptides and Proteins; Lymphokines; Mice; Oxygen; Receptors, Purinergic P1; Retinal Neovascularization; Retinopathy of Prematurity; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
Adenosine receptors and Huntington's disease: implications for pathogenesis and therapeutics.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Corpus Striatum; Disease Models, Animal; Humans; Huntington Disease; Mitochondrial Diseases; Models, Molecular; Models, Neurological; Mutation; Neural Networks, Computer; Neuroprotective Agents; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptors, Dopamine | 2003 |
Adenosine receptors as targets for drug development.
Topics: Adenosine; Animals; Animals, Genetically Modified; Disease Models, Animal; Drug Design; Drug Evaluation; Humans; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1; Structure-Activity Relationship | 2003 |
Mitochondrial ATP-sensitive potassium channels in surgical cardioprotection.
Topics: Adenosine; Adenosine Triphosphate; Animals; Cardiotonic Agents; Diazoxide; Disease Models, Animal; Heart Arrest, Induced; Humans; Ischemic Preconditioning, Myocardial; Mitochondria, Heart; Myocardial Ischemia; Myocardial Reperfusion Injury; Potassium Channel Blockers; Potassium Channels; Sarcolemma | 2003 |
Role of adenosine in immunomodulation: review of the literature.
Topics: Adenosine; Animals; Critical Care; Critical Illness; Disease Models, Animal; Female; Follow-Up Studies; Humans; Immunity; Male; Multiple Organ Failure; Neutrophil Activation; Randomized Controlled Trials as Topic; Reperfusion Injury; Risk Assessment; Survival Analysis; Treatment Outcome | 2004 |
Emerging concepts in periventricular white matter injury.
Topics: Adenosine; Animals; Biomarkers; Disease Models, Animal; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Infant, Premature; Infant, Very Low Birth Weight; Inflammation; Leukomalacia, Periventricular; Microglia; Neurons; Oligodendroglia; Oxidative Stress; Reactive Nitrogen Species; Reactive Oxygen Species; Risk Factors; Stem Cells | 2004 |
The role of protein kinase C in cerebral ischemic and reperfusion injury.
Topics: Adenosine; Animals; Apoptosis; Brain Ischemia; Disease Models, Animal; Humans; Ischemic Preconditioning; Isoenzymes; Neurons; Protein Kinase C; Reperfusion Injury; Up-Regulation | 2005 |
Adenosine signaling in asthma and chronic obstructive pulmonary disease.
Topics: Adenosine; Animals; Asthma; Bronchoconstriction; Disease Models, Animal; Humans; Lung; Mast Cells; Mice; Pulmonary Disease, Chronic Obstructive; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Receptors, Purinergic P1 | 2006 |
[Postconditioning: a brief review].
Topics: Adenosine; Anesthetics; Animals; Collateral Circulation; Disease Models, Animal; Dogs; Humans; Ischemic Preconditioning, Myocardial; Mice; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Stunning; Myocytes, Cardiac; Rabbits; Rats; Reactive Oxygen Species; Reperfusion Injury; Thoracic Surgery; Time Factors | 2006 |
Cell therapy in models for temporal lobe epilepsy.
Topics: Acetylcholine; Adenosine; Animals; Cell Transplantation; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Fetus; gamma-Aminobutyric Acid; Hippocampus; Humans; Nerve Net; Neurons; Norepinephrine; Pregnancy; Stem Cell Transplantation | 2007 |
Adenosine receptor antagonists for cognitive dysfunction: a review of animal studies.
Topics: Adenosine; Alzheimer Disease; Animals; Attention Deficit Disorder with Hyperactivity; Cognition Disorders; Disease Models, Animal; Humans; Learning; Memory; Parkinson Disease; Purinergic P1 Receptor Antagonists; Rats; Rats, Inbred SHR; Receptors, Purinergic P1 | 2008 |
Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis.
Topics: Adenosine; Animals; Apoptosis; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Proliferation; Clinical Trials as Topic; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Folic Acid; Humans; Immunity, Cellular; Immunosuppression Therapy; Male; Methotrexate; Reactive Oxygen Species; Sensitivity and Specificity; Treatment Outcome | 2008 |
Renal nerves in the pathogenesis of hypertension in experimental animals and humans.
Topics: Adenosine; Afferent Pathways; Animals; Disease Models, Animal; Humans; Hypertension; Hypertension, Renovascular; Kidney; Kidney Tubules; Regional Blood Flow; Renal Circulation; Vascular Resistance | 1983 |
[Animal models of bronchial hyperreactivity].
Topics: Adenosine; Animals; Asthma; Bradykinin; Bronchial Hyperreactivity; Bronchial Provocation Tests; Chronic Disease; Cytokines; Dextrans; Disease Models, Animal; Dogs; Guinea Pigs; Inflammation; Leukotrienes; Lipoxygenase; Mast Cells; Ozone; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Tachykinins | 1994 |
Experience from experimental models in the quest to protect myocardium from ischemic damage: update on preconditioning strategies.
Topics: Adenosine; Animals; Coronary Circulation; Disease Models, Animal; Heart; Humans; Myocardial Ischemia; Myocardium; Potassium Channels; Receptors, Adrenergic, alpha | 1994 |
Cardiac preconditioning. Induction of endogenous tolerance to ischemia-reperfusion injury.
Topics: Adenosine; Animals; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Energy Metabolism; Humans; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardial Stunning; Phenylephrine; Protein Kinase C; Rats; Receptors, Adrenergic, alpha; Receptors, Purinergic P1; Signal Transduction | 1993 |
Adenosine in the heart: its emerging roles.
Topics: Adenosine; Animals; Blood Flow Velocity; Calcium Channels; Clinical Trials as Topic; Coronary Vessels; Diagnosis, Differential; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Exercise Test; Heart Rate; Hemodynamics; Humans; Potassium Channels; Receptors, Purinergic; Signal Transduction; Tachycardia, Paroxysmal; Tachycardia, Supraventricular | 1993 |
Acute renal failure.
Topics: Acute Disease; Acute Kidney Injury; Adenosine; Age Factors; Angiotensin II; Animals; Animals, Newborn; Blood Flow Velocity; Calcium Channels; Disease Models, Animal; Endothelins; Free Radicals; Glomerular Filtration Rate; Humans; Hypoxia; Infant, Newborn; Rabbits; Reactive Oxygen Species; Renal Circulation; Risk Factors | 1993 |
Adenosine attenuates reperfusion injury following regional myocardial ischaemia.
Topics: Adenosine; Animals; Disease Models, Animal; Dogs; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Rabbits; Receptors, Purinergic | 1993 |
Adenosine for pain control.
Topics: Acute Disease; Adenosine; Analgesics; Analgesics, Opioid; Animals; Central Nervous System; Chronic Disease; Disease Models, Animal; Hot Temperature; Humans; Infusions, Intravenous; Injections, Intravenous; Injections, Spinal; Neurons, Afferent; Nociceptors; Pain; Peripheral Nerves; Pressure; Receptors, Cell Surface; Rodentia; Spinal Cord; Touch | 1997 |
The importance of adenosine deaminase for lymphocyte development and function.
Topics: Adenosine; Adenosine Deaminase; Animals; Deoxyadenosines; Disease Models, Animal; Humans; Lymphocytes; Mice; Severe Combined Immunodeficiency | 2000 |
Species differences in adenosine receptor-mediated bronchoconstrictor responses.
Topics: Adenosine; Animals; Asthma; Bronchoconstriction; Disease Models, Animal; Guinea Pigs; Humans; Rabbits; Rats; Receptors, Purinergic P1; Species Specificity | 2000 |
Adenosine deaminase-deficient mice: models for the study of lymphocyte development and adenosine signaling.
Topics: Adenosine; Adenosine Deaminase; Adenosylhomocysteinase; Animals; Deoxyadenosines; Disease Models, Animal; Humans; Hydrolases; Lymphocytes; Mice; Mice, Knockout; Receptor, Adenosine A3; Receptors, Purinergic P1; Severe Combined Immunodeficiency; Signal Transduction | 2000 |
Molecular action of methotrexate in inflammatory diseases.
Topics: Adenosine; Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Methotrexate; Receptors, Purinergic P1 | 2002 |
Neural and molecular mechanisms in anxiety.
Topics: Adenosine; Animals; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Binding, Competitive; Carbolines; Clonidine; Disease Models, Animal; Forecasting; Haplorhini; Humans; Locus Coeruleus; Piperoxan; Rats; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Purinergic; Research Design; Yohimbine | 1985 |
[Action of adenosine on intestinal motility after experimental mesenteric ischemia in dogs].
Topics: Adenosine; Animals; Disease Models, Animal; Dogs; Electromyography; Female; Gastrointestinal Motility; Ischemia; Jejunum; Mesenteric Arteries | 1988 |
A review: The obese strain (OS) of chickens: an animal model with spontaneous autoimmune thyroiditis.
Topics: Adenosine; Animals; Animals, Newborn; Autoantibodies; Autoimmune Diseases; B-Lymphocytes; Basement Membrane; Bursa of Fabricius; Chick Embryo; Chickens; Chromium Radioisotopes; Complement Fixation Tests; Disease Models, Animal; Fluorescent Antibody Technique; Hemagglutination Tests; Hypothyroidism; Immunization, Passive; Immunodiffusion; Iodine Radioisotopes; Obesity; Organ Specificity; Phenotype; Thyroglobulin; Thyroid Function Tests; Thyroid Gland; Thyroiditis; Thyroxine; Tritium | 1974 |
7 trial(s) available for adenosine and Disease Models, Animal
| Article | Year |
|---|---|
Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs.
Topics: Adenosine; Animals; Antineoplastic Agents; Disease Models, Animal; Head and Neck Neoplasms; Humans; Immunotherapy; Mice; Phosphatidylinositol 3-Kinases; Quinolines; T-Lymphocytes, Regulatory | 2022 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acrylic Resins; Actinobacillus; Acute Disease; Acute Kidney Injury; Adaptor Proteins, Signal Transducing; Adenosine; Adenosine Triphosphate; Administration, Inhalation; Administration, Oral; Adolescent; Adult; Advance Care Planning; Africa, Northern; Age Factors; Aged; Aged, 80 and over; Air Pollutants; Air Pollution; Air Pollution, Indoor; Albendazole; Aluminum Oxide; Anastomosis, Surgical; Ancylostoma; Ancylostomiasis; Androstadienes; Angiogenesis Inhibitors; Angiotensin II; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antibodies, Bispecific; Antibodies, Viral; Anticoagulants; Antihypertensive Agents; Antinematodal Agents; Antineoplastic Agents; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antiporters; Antiviral Agents; Apoptosis; Aptamers, Nucleotide; Aromatase Inhibitors; Asian People; Astrocytes; Atrial Fibrillation; Auditory Threshold; Aurora Kinase B; Australia; Autophagy; Autophagy-Related Protein 5; Autotrophic Processes; Bacillus cereus; Bacillus thuringiensis; Bacterial Proteins; Beclin-1; Belgium; Benzene; Benzene Derivatives; Benzhydryl Compounds; beta Catenin; beta-Arrestin 2; Biliary Tract Diseases; Biofilms; Biofuels; Biomarkers; Biomarkers, Tumor; Biomass; Biomechanical Phenomena; Bioreactors; Biosensing Techniques; Biosynthetic Pathways; Bismuth; Blood Platelets; Bone and Bones; Bone Regeneration; Bortezomib; Botulinum Toxins, Type A; Brain; Brain Injuries; Brain Ischemia; Brain Neoplasms; Breast Neoplasms; Breath Tests; Bronchodilator Agents; Calcium Phosphates; Cannabis; Carbon Dioxide; Carbon Isotopes; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cardiac Resynchronization Therapy; Cardiac Resynchronization Therapy Devices; Cardiomyopathies; Cardiovascular Diseases; Cariostatic Agents; Case Managers; Case-Control Studies; Catalysis; Cation Transport Proteins; CD8-Positive T-Lymphocytes; Cecropia Plant; Cell Adhesion; Cell Count; Cell Differentiation; Cell Division; Cell Line; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Cell Self Renewal; Cell Survival; Cells, Cultured; Cellular Reprogramming; Cellulose; Charcoal; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemokines; Chemoradiotherapy; Chemoreceptor Cells; Child; Child Abuse; Child, Preschool; China; Chlorogenic Acid; Chloroquine; Chromatography, Gas; Chronic Disease; Clinical Competence; Coated Materials, Biocompatible; Cochlea; Cohort Studies; Color; Comorbidity; Computer Simulation; Computer-Aided Design; Contraception; Contraceptive Agents, Female; Contrast Media; COP-Coated Vesicles; Coronavirus Infections; Cost of Illness; Coturnix; COVID-19; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Culex; Curriculum; Cyclic N-Oxides; Cytokines; Cytoplasm; Cytotoxicity, Immunologic; Cytotoxins; Databases, Factual; Deep Learning; Delivery, Obstetric; Denitrification; Dental Caries; Denture, Complete; Dexamethasone; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dielectric Spectroscopy; Diet, High-Fat; Dietary Fiber; Disease Models, Animal; Disease Progression; DNA; DNA Copy Number Variations; DNA, Mitochondrial; Dog Diseases; Dogs; Dopaminergic Neurons; Double-Blind Method; Down-Regulation; Doxorubicin; Drug Carriers; Drug Design; Drug Interactions; Drug Resistance, Bacterial; Drug Resistance, Neoplasm; Drug-Related Side Effects and Adverse Reactions; Drugs, Chinese Herbal; Dry Powder Inhalers; Dust; E2F1 Transcription Factor; Ecosystem; Education, Nursing; Education, Nursing, Baccalaureate; Electric Impedance; Electricity; Electrocardiography; Electrochemical Techniques; Electrochemistry; Electrodes; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Endothelial Cells; Environmental Monitoring; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Estrogen Receptor Modulators; Europe; Evoked Potentials, Auditory, Brain Stem; Exosomes; Feasibility Studies; Female; Ferricyanides; Ferrocyanides; Fibrinogen; Finite Element Analysis; Fistula; Fluorescent Dyes; Fluorides, Topical; Fluorodeoxyglucose F18; Fluticasone; Follow-Up Studies; Food Contamination; Food Microbiology; Foods, Specialized; Forensic Medicine; Frail Elderly; France; Free Radicals; Fresh Water; Fungi; Fungicides, Industrial; Galactosamine; Gastrointestinal Neoplasms; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Frequency; Genetic Predisposition to Disease; Genotype; Gingival Hemorrhage; Glioblastoma; Glioma; Glomerular Filtration Rate; Glomerulosclerosis, Focal Segmental; Glucose; Glucose Transport Proteins, Facilitative; Glucosides; Glutamine; Glycolysis; Gold; GPI-Linked Proteins; Gram-Negative Bacteria; Gram-Positive Bacteria; Graphite; Haplotypes; HCT116 Cells; Healthy Volunteers; Hearing Loss; Heart Failure; Hedgehog Proteins; HEK293 Cells; HeLa Cells; Hemodynamics; Hemorrhage; Hepatocytes; Hippo Signaling Pathway; Histone Deacetylases; Homeostasis; Hospital Mortality; Hospitalization; Humans; Hydantoins; Hydrazines; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Hydroxylamines; Hypoglycemic Agents; Immunity, Innate; Immunoglobulin G; Immunohistochemistry; Immunologic Factors; Immunomodulation; Immunophenotyping; Immunotherapy; Incidence; Indazoles; Indonesia; Infant; Infant, Newborn; Infarction, Middle Cerebral Artery; Inflammation; Injections, Intramuscular; Insecticides; Insulin-Like Growth Factor I; Insurance, Health; Intention to Treat Analysis; Interleukin-1 Receptor-Associated Kinases; Interleukin-6; Intrauterine Devices; Intrauterine Devices, Copper; Iron; Ischemia; Jordan; Keratinocytes; Kidney; Kidney Diseases; Kir5.1 Channel; Klebsiella Infections; Klebsiella pneumoniae; Lab-On-A-Chip Devices; Laparoscopy; Lasers; Lasers, Semiconductor; Lenalidomide; Leptin; Lethal Dose 50; Levonorgestrel; Limit of Detection; Lipid Metabolism; Lipid Metabolism Disorders; Lipogenesis; Lipopolysaccharides; Liquid Biopsy; Liver; Liver Abscess, Pyogenic; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Longevity; Lung Neoplasms; Luteolin; Lymph Nodes; Lymphocyte Activation; Macaca fascicularis; Macrophages; Mad2 Proteins; Magnetic Resonance Imaging; Male; Mammary Glands, Human; Manganese; Manganese Compounds; MAP Kinase Signaling System; Materials Testing; Maternal Health Services; MCF-7 Cells; Medicaid; Medicine, Chinese Traditional; Melanoma; Membrane Proteins; Mental Health; Mercury; Metal Nanoparticles; Metals, Heavy; Metformin; Methionine Adenosyltransferase; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Mice, Nude; Microalgae; Microbial Sensitivity Tests; Microglia; MicroRNAs; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Middle Aged; Mitochondria; Mitochondrial Proteins; Mitral Valve; Mitral Valve Insufficiency; Models, Anatomic; Molecular Structure; Molybdenum; Monocarboxylic Acid Transporters; Moths; MPTP Poisoning; Multigene Family; Multiparametric Magnetic Resonance Imaging; Multiple Myeloma; Muscle, Skeletal; Mutagens; Mutation; Myeloid Cells; Nanocomposites; Nanofibers; Nanomedicine; Nanoparticles; Nanowires; Neoadjuvant Therapy; Neomycin; Neoplasm Grading; Neoplasm Recurrence, Local; Neoplasms; Neoplastic Stem Cells; Neostriatum; Neovascularization, Pathologic; Netherlands; Neuromuscular Agents; Neurons; NF-E2-Related Factor 2; NF-kappa B; Nickel; Nitrogen Oxides; Non-alcoholic Fatty Liver Disease; Nucleosides; Nucleotidyltransferases; Nutritional Status; Obesity, Morbid; Ofloxacin; Oils, Volatile; Oligopeptides; Oncogene Protein v-akt; Optical Imaging; Organic Cation Transport Proteins; Organophosphonates; Osteoarthritis; Osteoarthritis, Hip; Osteoarthritis, Knee; Osteoblasts; Osteogenesis; Oxidation-Reduction; Oxidative Stress; Oxides; Oxygen Isotopes; Pancreas; Pancreaticoduodenectomy; Pandemics; Particle Size; Particulate Matter; Patient Acceptance of Health Care; Patient Compliance; PC-3 Cells; Peptide Fragments; Peptides; Periodontal Attachment Loss; Periodontal Index; Periodontal Pocket; Periodontitis; Peroxides; Peru; Pest Control, Biological; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Phylogeny; Pilot Projects; Piperidines; Plant Bark; Plant Extracts; Plant Leaves; Plasmids; Platelet Function Tests; Pneumonia, Viral; Podocytes; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Polyethylene Terephthalates; Polymers; Polymorphism, Single Nucleotide; Porosity; Portugal; Positron-Emission Tomography; Postoperative Complications; Postural Balance; Potassium Channels, Inwardly Rectifying; Povidone; Powders; Precancerous Conditions; Precision Medicine; Predictive Value of Tests; Pregnancy; Prenatal Care; Prognosis; Promoter Regions, Genetic; Prospective Studies; Prostatectomy; Prostatic Neoplasms; Proteasome Inhibitors; Protective Agents; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; Psychiatric Nursing; PTEN Phosphohydrolase; Pulmonary Embolism; Pyrimethamine; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reactive Oxygen Species; Receptor, ErbB-2; Receptor, IGF Type 1; Receptors, Estrogen; Receptors, G-Protein-Coupled; Recombinational DNA Repair; Recovery of Function; Regional Blood Flow; Renal Dialysis; Renin; Renin-Angiotensin System; Reperfusion Injury; Reproducibility of Results; Republic of Korea; Respiratory Distress Syndrome; Retrospective Studies; Rhodamines; Risk Assessment; Risk Factors; RNA, Long Noncoding; RNA, Messenger; Running; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salinity; Salmeterol Xinafoate; Sarcoma; Seasons; Shoulder Injuries; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Sirtuins; Skull Fractures; Social Determinants of Health; Sodium; Sodium Fluoride; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Glucose Transporter 2 Inhibitors; Soil; Soil Pollutants; Spain; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Staphylococcal Protein A; Staphylococcus aureus; Stem Cells; Stereoisomerism; Stomach Neoplasms; Streptomyces; Strontium; Structure-Activity Relationship; Students, Nursing; Substance-Related Disorders; Succinic Acid; Sulfur; Surface Properties; Survival Rate; Survivin; Symporters; T-Lymphocytes; Temozolomide; Tensile Strength; Thiazoles; Thiobacillus; Thiohydantoins; Thiourea; Thrombectomy; Time Factors; Titanium; Tobacco Mosaic Virus; Tobacco Use Disorder; Toll-Like Receptor 4; Toluene; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Toxicity Tests, Acute; Toxicity Tests, Subacute; Transcriptional Activation; Treatment Outcome; Troponin I; Tumor Cells, Cultured; Tumor Escape; Tumor Hypoxia; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Tyrosine; Ubiquitin-Protein Ligases; Ubiquitination; Ultrasonic Waves; United Kingdom; United States; United States Department of Veterans Affairs; Up-Regulation; Urea; Uric Acid; Urinary Bladder Neoplasms; Urinary Bladder, Neurogenic; Urine; Urodynamics; User-Computer Interface; Vemurafenib; Verbenaceae; Veterans; Veterans Health; Viral Load; Virtual Reality; Vitiligo; Water Pollutants, Chemical; Wildfires; Wnt Signaling Pathway; Wound Healing; X-Ray Diffraction; Xenograft Model Antitumor Assays; Xylenes; Young Adult; Zinc; Zinc Oxide; Zinc Sulfate; Zoonoses | 2021 |
Short-Term Hypoxia Dampens Inflammation in vivo via Enhanced Adenosine Release and Adenosine 2B Receptor Stimulation.
Topics: Adenosine; Animals; Disease Models, Animal; Endotoxemia; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Interleukin-10; Mice; Receptors, Purinergic P1; Up-Regulation | 2018 |
Plasma glutamate-modulated interaction of A2AR and mGluR5 on BMDCs aggravates traumatic brain injury-induced acute lung injury.
Topics: Acute Lung Injury; Adenosine; Adenosine A2 Receptor Agonists; Adult; Animals; Bone Marrow Cells; Brain Injuries; Disease Models, Animal; Female; Glutamic Acid; Humans; Male; Mice; Mice, Knockout; Middle Aged; Phenethylamines; Protein Kinase C; Receptor, Adenosine A2A; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Signal Transduction; Triazines; Triazoles; Type C Phospholipases | 2013 |
Impairment of adenosine A3 receptor activity disrupts neutrophil migratory capacity and impacts innate immune function in vivo.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Animals; Chemotaxis; Colitis; Dextran Sulfate; Disease Models, Animal; Humans; Immunity, Innate; Inflammation; Mice; Mice, Knockout; Neutrophils; Quinazolines; Receptor, Adenosine A3; Triazoles; Up-Regulation | 2012 |
Adenosine modulation of neurotransmission in penile erection.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adult; Aged; Alprostadil; Animals; Antihypertensive Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Erectile Dysfunction; Humans; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Norepinephrine; Penile Erection; Penis; Phenethylamines; Phenylisopropyladenosine; Purinergic P1 Receptor Agonists; Rabbits; Synaptic Transmission; Theobromine; Vasodilator Agents | 1994 |
Adenosine during cardiac arrest and cardiopulmonary resuscitation: a placebo-controlled, randomized trial.
Topics: Acid-Base Equilibrium; Adenosine; Animals; Blood Gas Analysis; Cardiopulmonary Resuscitation; Coronary Circulation; Disease Models, Animal; Heart Arrest; Hemodynamics; Infusions, Intravenous; Male; Rats; Rats, Inbred Strains; Survival Rate; Tidal Volume | 1992 |
794 other study(ies) available for adenosine and Disease Models, Animal
| Article | Year |
|---|---|
Neuroprotective principles from Gastrodia elata.
Topics: Adenosine; Animals; Apoptosis; Disease Models, Animal; Drugs, Chinese Herbal; Gastrodia; Molecular Structure; Neuroprotective Agents; PC12 Cells; Plants, Medicinal; Rats; Receptor, Adenosine A2A; Serum; Sulfides | 2007 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Positive allosteric mechanisms of adenosine A
Topics: Adenosine; Allosteric Regulation; Analgesia; Animals; Binding Sites; Disease Models, Animal; Female; GTP-Binding Protein alpha Subunit, Gi2; Hyperalgesia; Lipids; Male; Neuralgia; Protein Stability; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Signal Transduction | 2021 |
TNF-α-mediated m
Topics: Adaptor Proteins, Signal Transducing; Adenosine; Animals; beta-Glucans; Biopsy; Bone Marrow; Case-Control Studies; Cell Differentiation; Cell Movement; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Female; Healthy Volunteers; HEK293 Cells; Humans; Male; Mesenchymal Stem Cells; Mice; Osteogenesis; Primary Cell Culture; Spondylitis, Ankylosing; Tumor Necrosis Factor-alpha; X-Ray Microtomography | 2021 |
Positive Allosteric Modulation of A
Topics: Adenosine; Animals; Cytokines; Dermatitis; Disease Models, Animal; Imiquimod; Immunity; Interleukin-17; Interleukin-23; Mice; Mice, Inbred BALB C; Psoriasis; Skin | 2022 |
DZNep protects against retinal ganglion cell death in an NMDA-induced mouse model of retinal degeneration.
Topics: Adenosine; Animals; Cell Count; Cell Death; Disease Models, Animal; Electroretinography; Intravitreal Injections; Male; Mice; N-Methylaspartate; Retinal Degeneration; Retinal Ganglion Cells | 2021 |
METTL3 regulates hippocampal gene transcription via N6-methyladenosine methylation in sevoflurane-induced postoperative cognitive dysfunction mouse.
Topics: Adenosine; Animals; Disease Models, Animal; DNA Methylation; Female; Hippocampus; MAP Kinase Signaling System; Methyltransferases; Mice; Mice, Inbred C57BL; Postoperative Cognitive Complications; Sevoflurane; Transcription, Genetic | 2021 |
m6A regulator-mediated RNA methylation modification patterns and immune microenvironment infiltration characterization in severe asthma.
Topics: Adenosine; Animals; Asthma; Biomarkers; Cellular Microenvironment; Computational Biology; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Humans; Methylation; Mice; Models, Biological; RNA, Messenger; ROC Curve; Severity of Illness Index; Transcriptome | 2021 |
METTL3-mediated m
Topics: Adenosine; Animals; Autophagy; Autophagy-Related Protein 7; Cartilage, Articular; Cell Line; Cellular Senescence; Chondrocytes; Coculture Techniques; Disease Models, Animal; Disease Progression; Female; GATA4 Transcription Factor; Gene Expression; Humans; Immunoprecipitation; Male; Methylation; Methyltransferases; Mice; Middle Aged; Osteoarthritis; RNA Processing, Post-Transcriptional; RNA-Binding Proteins; RNA, Messenger; RNA, Small Interfering; Synoviocytes; Up-Regulation | 2022 |
Downregulation of microRNA-6125 promotes colorectal cancer growth through YTHDF2-dependent recognition of N6-methyladenosine-modified GSK3β.
Topics: Adenosine; Animals; Colorectal Neoplasms; Disease Models, Animal; Down-Regulation; Glycogen Synthase Kinase 3 beta; Mice; MicroRNAs; RNA-Binding Proteins | 2021 |
Involvement of METTL3/m
Topics: Adenosine; Animals; Biomarkers; Disease Models, Animal; Disease Susceptibility; Extracellular Matrix; Fibroblasts; Gene Expression Regulation; Glaucoma; Humans; Immunohistochemistry; Methyltransferases; Rabbits; Signal Transduction; Smad3 Protein; Tenon Capsule; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2021 |
Topics: Adenosine; Allergens; Animals; Asthma; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Epigenome; Female; Gene Expression Profiling; Humans; Hypersensitivity; Immunity; Lung; Mice; Mice, Inbred BALB C; Ovalbumin; Signal Transduction | 2021 |
Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets.
Topics: Adenosine; Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; COVID-19; COVID-19 Drug Treatment; Cricetinae; Disease Models, Animal; Female; Ferrets; Humans; Prodrugs; SARS-CoV-2 | 2021 |
Alteration of the m
Topics: Adenosine; Animals; Autoimmune Diseases; Bleomycin; Connective Tissue Diseases; Disease Models, Animal; Female; Fibrosis; Gene Expression; Methylation; Mice, Inbred BALB C; RNA, Messenger; Skin | 2021 |
ALM Fluid Therapy Shifts Sympathetic Hyperactivity to Parasympathetic Dominance in the Rat Model of Non-Compressible Hemorrhagic Shock.
Topics: Adenosine; Animals; Disease Models, Animal; Drug Combinations; Fluid Therapy; Lidocaine; Magnesium; Male; Parasympathetic Nervous System; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic; Sympathetic Nervous System | 2022 |
CF101 alleviates OA progression and inhibits the inflammatory process via the AMP/ATP/AMPK/mTOR axis.
Topics: Adenosine; Adenosine Monophosphate; Adenosine Triphosphate; AMP-Activated Protein Kinases; Animals; Cartilage, Articular; Chondrocytes; Collagen Type II; Disease Models, Animal; Inflammation; Osteoarthritis; Rats; TOR Serine-Threonine Kinases | 2022 |
Fat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice.
Topics: Adenosine; Adult; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Case-Control Studies; Depressive Disorder, Major; Disease Models, Animal; Down-Regulation; Female; Gene Knockdown Techniques; Healthy Volunteers; Hippocampus; Humans; Male; Methylation; Mice; Mice, Knockout; Middle Aged; Receptors, Adrenergic, beta-2; Young Adult | 2021 |
Adenosine, lidocaine, and magnesium for attenuating ischemia reperfusion injury from resuscitative endovascular balloon occlusion of the aorta in a porcine model.
Topics: Adenosine; Animals; Aorta; Balloon Occlusion; Disease Models, Animal; Endovascular Procedures; Hemorrhage; Lidocaine; Magnesium; Reperfusion Injury; Shock, Hemorrhagic; Swine | 2022 |
Activity of Galidesivir in a Hamster Model of SARS-CoV-2.
Topics: Adenine; Adenosine; Animals; Antiviral Agents; Cell Line; COVID-19; COVID-19 Drug Treatment; Cricetinae; Disease Models, Animal; Humans; Lung; Mesocricetus; Pyrrolidines; SARS-CoV-2; Viral Load | 2021 |
Differential release of extracellular vesicle tRNA from oxidative stressed renal cells and ischemic kidneys.
Topics: Acute Kidney Injury; Adenosine; Animals; Cell Line; Disease Models, Animal; Extracellular Vesicles; Ischemia; Kidney; Methylation; Mice; Oxidative Stress; Rats, Sprague-Dawley; Repressor Proteins; RNA, Transfer; Transcription, Genetic | 2022 |
Pharmacological Study of A3 Adenosine Receptor agonist (AB Meca) in Xenograft Lung Cancer Model in Mice through In Silico and In Vivo Approach: Targeting TNF-α.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Disease Models, Animal; Doxorubicin; Heterografts; Humans; Lung Neoplasms; Mice; Molecular Docking Simulation; Rats; Tumor Necrosis Factor-alpha | 2022 |
Lowering the Intraocular Pressure in Rats and Rabbits by
Topics: Adenosine; Animals; Apoptosis; Cordyceps; Disease Models, Animal; Glaucoma; Intraocular Pressure; Male; Mycelium; Rabbits; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells | 2022 |
Adenosine Kinase Isoforms in the Developing Rat Hippocampus after LiCl/Pilocarpine Status Epilepticus.
Topics: Adenosine; Adenosine Kinase; Animals; Anticonvulsants; Disease Models, Animal; Hippocampus; Pilocarpine; Protein Isoforms; Rats; Status Epilepticus | 2022 |
Inhibition of TLR4 Suppresses the Inflammatory Response in Inflammatory Bowel Disease (IBD) by Modulating the PDK1-Induced Metabolism Reprogramming via a m6A-Denpendent Manner.
Topics: Adenosine; Animals; Colon; Dextran Sulfate; Disease Models, Animal; Inflammatory Bowel Diseases; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Toll-Like Receptor 4 | 2022 |
Enteric glial adenosine 2B receptor signaling mediates persistent epithelial barrier dysfunction following acute DSS colitis.
Topics: Adenosine; Animals; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Inflammation; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Neuroglia | 2022 |
Neuroprotective Effects of a Cardioplegic Combination (Adenosine, Lidocaine, and Magnesium) in an Ischemic Stroke Model.
Topics: Adenosine; Animals; Cardioplegic Solutions; Cobalt; Disease Models, Animal; Glucose; Humans; Ischemic Stroke; Lidocaine; Magnesium; Neuroblastoma; Neuroprotective Agents; Oxygen; Rats; Stroke | 2022 |
WTAP Mediated the N6-methyladenosine Modification of PDK4 to Regulate the Malignant Behaviors of Colorectal Cancer Cells
Topics: Adenosine; Animals; Binding Sites; Cell Cycle Proteins; Colorectal Neoplasms; Disease Models, Animal; Humans; Mice; RNA Splicing Factors | 2023 |
Reduction of Methyltransferase-like 3-Mediated RNA N6-Methyladenosine Exacerbates the Development of Psoriasis Vulgaris in Imiquimod-Induced Psoriasis-like Mouse Model.
Topics: Adenosine; Animals; Disease Models, Animal; Humans; Imiquimod; Inflammation; Methyltransferases; Mice; Psoriasis; RNA; RNA, Messenger | 2022 |
Changes in adenosine receptors and neurotrophic factors in the SOD1G93A mouse model of amyotrophic lateral sclerosis: Modulation by chronic caffeine.
Topics: Adenosine; Amyotrophic Lateral Sclerosis; Animals; Brain-Derived Neurotrophic Factor; Caffeine; Disease Models, Animal; Mice; Mice, Transgenic; Receptors, Purinergic P1; Spinal Cord; Superoxide Dismutase; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2022 |
Topical Adenosine Inhibits Inflammation and Mucus Production in Viral Acute Rhinosinusitis.
Topics: Adenosine; Animals; Disease Models, Animal; Inflammation; Mice; Mucins; Mucus; Sinusitis | 2023 |
Cordycepin improved the cognitive function through regulating adenosine A
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adenosine; Animals; Cognition; Disease Models, Animal; Mice; Mice, Inbred C57BL; Parkinson Disease | 2023 |
P2X7 receptor-mediated depression-like reactions arising in the mouse medial prefrontal cortex.
Topics: Adenosine; Adenosine Triphosphate; Animals; Depression; Depressive Disorder, Major; Disease Models, Animal; Mice; Prefrontal Cortex; Receptors, Purinergic P2X7 | 2023 |
Enokitake Mushroom and Its Active Component, Adenosine, Which Restores Testosterone Production in Impaired and Fatigued Mouse Models.
Topics: Adenosine; Agaricales; Animals; Disease Models, Animal; Fatigue; Flammulina; Mice; Testosterone; Vegetables | 2023 |
Dznep, a histone modification inhibitor, inhibits HIF1α binding to TIMP2 gene and suppresses TIMP2 expression under hypoxia.
Topics: Acute Kidney Injury; Adenosine; Animals; Disease Models, Animal; Epigenesis, Genetic; Histone Code; Humans; Mice; Tissue Inhibitor of Metalloproteinase-2 | 2023 |
METTL3/IGF2BP2 axis affects the progression of colorectal cancer by regulating m6A modification of STAG3.
Topics: Adenosine; Animals; Cell Cycle Proteins; Colorectal Neoplasms; Disease Models, Animal; Humans; Methyltransferases; Mice; Mice, Nude; RNA-Binding Proteins; RNA, Messenger | 2023 |
Adenosinergic System and BDNF Signaling Changes as a Cross-Sectional Feature of RTT: Characterization of
Topics: Adenosine; Animals; Brain-Derived Neurotrophic Factor; Cross-Sectional Studies; Disease Models, Animal; Female; Humans; Methyl-CpG-Binding Protein 2; Mice; Mice, Knockout; Rett Syndrome | 2023 |
Frontline Science: Escherichia coli use LPS as decoy to impair neutrophil chemotaxis and defeat antimicrobial host defense.
Topics: Adenosine; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Apyrase; Biomarkers; Chemotaxis, Leukocyte; Disease Models, Animal; Escherichia coli; Escherichia coli Infections; Host-Pathogen Interactions; Humans; Intracellular Space; Lipopolysaccharides; Mice; Mitochondria; Neutrophil Activation; Neutrophils; Peritonitis | 2019 |
Synaptic and memory dysfunction in a β-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Triphosphate; Alzheimer Disease; Animals; Disease Models, Animal; Hippocampus; Long-Term Potentiation; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, Adenosine A2A | 2019 |
METTL3 inhibits hepatic insulin sensitivity via N6-methyladenosine modification of Fasn mRNA and promoting fatty acid metabolism.
Topics: Adenosine; Animals; Dependovirus; Diabetes Mellitus, Type 2; Disease Models, Animal; Fatty Acid Synthase, Type I; Fatty Acids; Gene Deletion; Glucose; Hepatocytes; Homeostasis; Humans; Insulin Resistance; Liver; Methylation; Methyltransferases; Mice, Inbred C57BL; Mice, Knockout; Obesity; RNA, Messenger | 2019 |
N
Topics: Adenosine; Adult; Aged; AlkB Homolog 5, RNA Demethylase; Animals; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Integrin alpha6; Male; Methyltransferases; Mice; Middle Aged; Neoplasm Grading; Neoplasm Staging; RNA, Messenger; Urinary Bladder Neoplasms | 2019 |
Vasodepressor Effects of Adenosine in the Cat are Independent of Cyclooxygenase, Potassium Channels, and Nitric Oxide Pathways.
Topics: Adenosine; Animals; Calcium Channels, L-Type; Cats; Disease Models, Animal; Female; Hypertension, Pulmonary; Male; Nitric Oxide; Potassium Channels; Prostaglandin-Endoperoxide Synthases; Receptor, Adenosine A1; Receptors, Adenosine A2; Signal Transduction; Vasodilator Agents | 2019 |
Augmenting the therapeutic efficacy of adenosine against pancreatic cancer by switching the Akt/p21-dependent senescence to apoptosis.
Topics: Adenosine; Animals; Apoptosis; Biomarkers, Tumor; Cell Line, Tumor; Cellular Senescence; Disease Models, Animal; Gene Silencing; Humans; Immunohistochemistry; Mice; Pancreatic Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; ras Proteins; Xenograft Model Antitumor Assays | 2019 |
Exogenous adenosine facilitates neuroprotection and functional recovery following cerebral ischemia in rats.
Topics: Adenosine; Animals; Brain; Brain Ischemia; CA1 Region, Hippocampal; Cell Death; Disease Models, Animal; Hippocampus; Male; Neurons; Neuroprotection; Neuroprotective Agents; Rats; Rats, Wistar; Recovery of Function; Reperfusion Injury | 2019 |
Genetic or pharmacologic blockade of enhancer of zeste homolog 2 inhibits the progression of peritoneal fibrosis.
Topics: Adenosine; Animals; Apoptosis; Cell Movement; Cells, Cultured; Disease Models, Animal; Enhancer of Zeste Homolog 2 Protein; Epithelial-Mesenchymal Transition; Humans; Male; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Pathologic; Peritoneal Fibrosis; Peritoneum; RNA Interference; RNA, Small Interfering; Signal Transduction | 2020 |
Adenosine in pancreatic cancer: Emerging combination therapies.
Topics: Adenosine; Animals; Antineoplastic Combined Chemotherapy Protocols; Disease Models, Animal; Disease Susceptibility; Humans; Mice; Pancreatic Neoplasms; Xenograft Model Antitumor Assays | 2019 |
METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer.
Topics: Adenosine; Animals; Biomarkers, Tumor; Cell Line, Tumor; Disease Models, Animal; ELAV-Like Protein 1; Epithelial-Mesenchymal Transition; Gene Expression Profiling; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Male; Methyltransferases; Mice; Neoplasm Metastasis; Neoplasm Staging; Prognosis; Proportional Hazards Models; Protein Binding; RNA, Messenger; Signal Transduction; Stomach Neoplasms; Transcriptome | 2019 |
Impaired dopamine- and adenosine-mediated signaling and plasticity in a novel rodent model for DYT25 dystonia.
Topics: Adenosine; Animals; Disease Models, Animal; Dopamine; Dystonia; Gene Knockout Techniques; GTP-Binding Protein alpha Subunits; Long-Term Synaptic Depression; Male; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Signal Transduction | 2020 |
N6-methyladenosine induced miR-143-3p promotes the brain metastasis of lung cancer via regulation of VASH1.
Topics: Adenosine; Animals; Blood-Brain Barrier; Brain Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Disease Models, Animal; Disease Progression; Epithelial-Mesenchymal Transition; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mice; MicroRNAs; Models, Biological; Neovascularization, Pathologic; RNA Interference; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2019 |
RETRACTED: METTL14 Suppresses CRC Progression via Regulating N6-Methyladenosine-Dependent Primary miR-375 Processing
Topics: Adenosine; Animals; Cell Line, Tumor; Colorectal Neoplasms; Disease Models, Animal; Disease Progression; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Methyltransferases; Mice; MicroRNAs; RNA Interference; Xenograft Model Antitumor Assays | 2020 |
KIAA1429 contributes to liver cancer progression through N6-methyladenosine-dependent post-transcriptional modification of GATA3.
Topics: Adenosine; Animals; Cell Line, Tumor; Disease Models, Animal; Disease Progression; GATA3 Transcription Factor; Humans; Liver Neoplasms; Methylation; Mice; Models, Biological; Neoplasm Metastasis; Prognosis; RNA Processing, Post-Transcriptional; RNA-Binding Proteins; RNA, Antisense; RNA, Long Noncoding; Xenograft Model Antitumor Assays | 2019 |
Inhibition of Disruptor of Telomeric Silencing 1-Like Alleviated Renal Ischemia and Reperfusion Injury-Induced Fibrosis by Blocking PI3K/AKT-Mediated Oxidative Stress.
Topics: Adenosine; Animals; Cells, Cultured; Disease Models, Animal; Fibrosis; Histone-Lysine N-Methyltransferase; Humans; Male; Oxidative Stress; Phenylurea Compounds; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2019 |
Adenosine accumulation causes metabolic disorders in testes and associates with lower testosterone level in obese mice.
Topics: Adenosine; Adenosine Monophosphate; Animals; Disease Models, Animal; Down-Regulation; Gene Expression; Male; Metabolic Diseases; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Testis; Testosterone; TOR Serine-Threonine Kinases; Up-Regulation | 2020 |
Antiallodynic and anti-inflammatory effects of intrathecal R-PIA in a rat model of vincristine-induced peripheral neuropathy.
Topics: Adenosine; Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Cold Temperature; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spinal; Male; Neuralgia; Neuroprotective Agents; Physical Stimulation; Rats; Rats, Sprague-Dawley; Vincristine | 2020 |
Targeting an adenosine-mediated "don't eat me signal" augments anti-lymphoma immunity by anti-CD20 monoclonal antibody.
Topics: Adenosine; Animals; Antibody-Dependent Cell Cytotoxicity; Antigens, CD20; Antineoplastic Agents, Immunological; Apyrase; Biomarkers; Cell Line, Tumor; Disease Models, Animal; Immunomodulation; Immunophenotyping; Kaplan-Meier Estimate; Killer Cells, Natural; Lymphoma; Macrophages; Mice; Mice, Knockout; Phagocytosis; Prognosis; Rituximab; Signal Transduction | 2020 |
Adenosine, Lidocaine, and Magnesium Support a High Flow, Hypotensive, Vasodilatory State With Improved Oxygen Delivery and Cerebral Protection in a Pig Model of Noncompressible Hemorrhage.
Topics: Adenosine; Animals; Brain; Brain Chemistry; Disease Models, Animal; Drug Administration Schedule; Drug Therapy, Combination; Female; Fluid Therapy; Glycerol; Humans; Hypotension; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia, Brain; Infusions, Intravenous; Injections, Intravenous; Lactic Acid; Lidocaine; Liver; Magnesium; Oxygen; Resuscitation; Shock, Hemorrhagic; Stroke Volume; Sus scrofa; Vascular Resistance; Vasodilation | 2020 |
Paeoniflorin exerts neuroprotective effects in a transgenic mouse model of Alzheimer's disease via activation of adenosine A
Topics: Adenosine; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Glucosides; Memory; Mice, Transgenic; Monoterpenes; Neuroprotective Agents; Receptor, Adenosine A1 | 2020 |
The Adenosine A2A Receptor Agonist Accelerates Bone Healing and Adjusts Treg/Th17 Cell Balance through Interleukin 6.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Disease Models, Animal; Female; Fracture Healing; Interleukin-6; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; T-Lymphocytes, Regulatory; Th17 Cells; Tibial Fractures | 2020 |
Adenosine A
Topics: Adenosine; Animals; Bone Marrow; Bone Marrow Transplantation; Brain Injuries; Cognitive Dysfunction; Disease Models, Animal; Mice, Inbred C57BL; Mice, Knockout; Receptor, Adenosine A2A; White Matter | 2020 |
Potential beneficial effects of caffeine administration in the neonatal period of an animal model of schizophrenia.
Topics: Adenosine; Animals; Animals, Newborn; Caffeine; Disease Models, Animal; Locomotion; Male; Motor Activity; Rats; Rats, Inbred SHR; Rats, Wistar; Schizophrenia | 2020 |
Disruption of hepatic one-carbon metabolism impairs mitochondrial function and enhances macrophage activity in methionine-choline-deficient mice.
Topics: Adenosine; Animals; Carbon; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Flavins; Guanidine; Inflammation; Liver; Macrophages; Male; Methionine; Mice; Mice, Inbred C57BL; Mitochondria; Nucleotides; Purinergic P1 Receptor Antagonists; Thymidine | 2020 |
Pharmacological targeting of striatal indirect pathway neurons improves subthalamic nucleus dysfunction and reduces repetitive behaviors in C58 mice.
Topics: Adenosine; Animals; Autism Spectrum Disorder; Basal Ganglia; Behavior, Animal; Benzamides; Compulsive Behavior; Corpus Striatum; Disease Models, Animal; Indoles; Male; Mice; Mice, Inbred Strains; Neural Pathways; Neurons; Phenethylamines; Piperidines; Pyrazoles; Stereotyped Behavior; Subthalamic Nucleus | 2020 |
m
Topics: Adenosine; Animals; Biomarkers; Bone Marrow Failure Disorders; Cell Differentiation; Disease Models, Animal; Epigenesis, Genetic; Gene Expression; Hematopoiesis; Hematopoietic Stem Cells; Immunity, Innate; Immunophenotyping; Methylation; Methyltransferases; Mice; Mice, Knockout; RNA, Double-Stranded | 2020 |
T1-11, an adenosine derivative, ameliorates aging-related behavioral physiology and senescence markers in aging mice.
Topics: Adenosine; Aging; Animals; Cellular Senescence; Cognitive Dysfunction; Disease Models, Animal; Galactose; Gastrodia; Hippocampus; Humans; Male; Mice; Neurogenesis; Neurons; Oxidative Stress; Reactive Oxygen Species | 2020 |
Squalene-based multidrug nanoparticles for improved mitigation of uncontrolled inflammation in rodents.
Topics: Adenosine; alpha-Tocopherol; Animals; Antioxidants; Betacoronavirus; Coronavirus Infections; COVID-19; Disease Models, Animal; Drug Delivery Systems; Endotoxemia; Female; Immunologic Factors; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nanoparticles; Pandemics; Pneumonia, Viral; SARS-CoV-2; Squalene; Systemic Inflammatory Response Syndrome; Treatment Outcome | 2020 |
Inhibition of EZH2 alleviates angiogenesis in a model of corneal neovascularization by blocking FoxO3a-mediated oxidative stress.
Topics: Adenosine; Animals; Cells, Cultured; Corneal Neovascularization; Disease Models, Animal; Enhancer of Zeste Homolog 2 Protein; Forkhead Box Protein O3; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia; Male; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction; Transcription, Genetic | 2020 |
A New Model of Spontaneous Colitis in Mice Induced by Deletion of an RNA m
Topics: Adenosine; Animals; Colitis; Disease Models, Animal; Gene Deletion; Methyltransferases; Mice; Mice, Knockout; T-Lymphocytes | 2020 |
Nitroxide-enhanced MRI of cardiovascular oxidative stress.
Topics: Adenosine; Angiotensin II; Animals; Cardiovascular System; Cyclic N-Oxides; Diet, High-Fat; Dietary Sucrose; Disease Models, Animal; Magnetic Resonance Imaging; Male; Mice, Inbred C57BL; Myocardial Infarction; Nitrogen Oxides; Obesity; Oxidative Stress; Perfusion; Pyrrolidines | 2020 |
Head-to-head comparative pharmacokinetic and biodistribution (PK/BD) study of two dexamethasone prodrug nanomedicines on lupus-prone NZB/WF1 mice.
Topics: Adenosine; Animals; Dexamethasone; Disease Models, Animal; Humans; Kidney; Lupus Nephritis; Mice; Mice, Inbred NZB; Nanomedicine; Nanoparticles; Polymers; Prodrugs; Spleen; Tissue Distribution | 2020 |
e5NT inhibitor protects acute restraint stress-induced depression by regulating nucleoside release in mice.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Diphosphate; Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Elevated Plus Maze Test; Enzyme Inhibitors; Exploratory Behavior; GPI-Linked Proteins; Hippocampus; Male; Mice; Open Field Test; Restraint, Physical; Stress, Psychological; Uridine | 2020 |
Effects of N
Topics: Adenosine; Animals; Disease Models, Animal; Electroencephalography; Male; Mice; Rats; Rodentia; Sleep Initiation and Maintenance Disorders; Sleep Wake Disorders; Stress, Psychological | 2021 |
The adenosine A(2A) receptor agonist CGS 21680 alleviates auditory sensorimotor gating deficits and increases in accumbal CREB in rats neonatally treated with quinpirole.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Animals, Newborn; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Female; Male; Motor Activity; Nucleus Accumbens; Phenethylamines; Prepulse Inhibition; Quinpirole; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Dopamine D2; Schizophrenia; Sensory Gating | 2020 |
Intraarticular injection of liposomal adenosine reduces cartilage damage in established murine and rat models of osteoarthritis.
Topics: Adenosine; Animals; Cartilage; Cartilage, Articular; Cell Differentiation; Chondrocytes; Disease Models, Animal; Injections, Intra-Articular; Liposomes; Male; Mice; Mice, Inbred C57BL; Osteoarthritis; Phenethylamines; Rats; Rats, Sprague-Dawley; Signal Transduction | 2020 |
β-catenin represses miR455-3p to stimulate m6A modification of HSF1 mRNA and promote its translation in colorectal cancer.
Topics: Adenosine; Animals; Apoptosis; beta Catenin; Cell Line, Tumor; Colorectal Neoplasms; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Heat Shock Transcription Factors; Humans; Methylation; Mice; MicroRNAs; Models, Biological; Protein Biosynthesis; RNA Interference; RNA, Messenger; Xenograft Model Antitumor Assays | 2020 |
N6-Methyladenosine modification of the TRIM7 positively regulates tumorigenesis and chemoresistance in osteosarcoma through ubiquitination of BRMS1.
Topics: Adenosine; Adolescent; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinogenesis; Cell Line, Tumor; Child; Chromatography, Liquid; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Mass Spectrometry; Mice; Neoplasm Staging; Osteosarcoma; Prognosis; Protein Binding; Repressor Proteins; Tripartite Motif Proteins; Ubiquitin-Protein Ligases; Ubiquitination | 2020 |
AGE-Induced Suppression of EZH2 Mediates Injury of Podocytes by Reducing H3K27me3.
Topics: Adenosine; Animals; Cell Line; Diabetic Nephropathies; Disease Models, Animal; DNA Methylation; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Glycation End Products, Advanced; Humans; Intracellular Signaling Peptides and Proteins; Mice; Podocytes; RNA, Small Interfering | 2020 |
Fusarium infection alters the m
Topics: Adenosine; Animals; Cornea; Disease Models, Animal; Eye Infections, Fungal; Fusariosis; Fusarium; Gene Expression Regulation; Keratitis; Male; Mice; Mice, Inbred BALB C; RNA Caps; RNA, Messenger; Up-Regulation | 2020 |
Buprenorphine Analgesia Reduces Survival With ALM Resuscitation in a Rat Model of Uncontrolled Hemorrhage: Concerns for Trauma-Related Research.
Topics: Adenosine; Analgesia; Analgesics, Opioid; Animals; Biomedical Research; Buprenorphine; Disease Models, Animal; Hemorrhage; Lidocaine; Magnesium; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Resuscitation; Survival Rate; Wounds and Injuries | 2021 |
The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N
Topics: Adenosine; Animals; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Glycogen Synthase Kinase 3 beta; Heart Ventricles; Hypertrophy, Left Ventricular; Male; Methylation; Methyltransferases; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac; NFATC Transcription Factors; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins; RNA Stability; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Ventricular Function, Left; Ventricular Remodeling | 2020 |
Adenosine Metabolism in the Cerebral Cortex from Several Mice Models during Aging.
Topics: Adenosine; Aging; Alzheimer Disease; Animals; Cellular Senescence; Cerebral Cortex; Disease Models, Animal; Hippocampus; Humans; Inosine; Mice; Phosphorylation; Xanthine | 2020 |
Inhibition of ecto-5'-nucleotidase and adenosine deaminase is able to reverse long-term behavioural effects of early ethanol exposure in zebrafish (Danio rerio).
Topics: 5'-Nucleotidase; Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Diphosphate; Animals; Antisocial Personality Disorder; Behavior, Animal; Disease Models, Animal; Ethanol; Female; Humans; Pregnancy; Prenatal Exposure Delayed Effects; Social Interaction; Zebrafish | 2020 |
New Chemical Probe Targeting Bacterial NAD Kinase.
Topics: Adenine; Adenosine; Amino Acid Sequence; Animals; Anti-Bacterial Agents; Bacterial Proteins; Disease Models, Animal; Enzyme Inhibitors; Mice; Models, Molecular; NADP; Phosphotransferases (Alcohol Group Acceptor); Protein Conformation; Sepharose; Staphylococcus aureus | 2020 |
Antinociceptive and neurochemical effects of a single dose of IB-MECA in chronic pain rat models.
Topics: Adenosine; Analgesics; Animals; Chronic Pain; Disease Models, Animal; Inflammation; Male; Neuralgia; Rats; Rats, Wistar | 2020 |
CD73
Topics: 5'-Nucleotidase; Adenosine; Adenosine Monophosphate; Animals; Autoimmune Diseases; Cell Communication; Cells, Cultured; Coculture Techniques; Cytokines; Dendritic Cells; Disease Models, Animal; Female; Genes, T-Cell Receptor delta; GPI-Linked Proteins; Lipopolysaccharides; Lymphocyte Activation; Mice, Inbred C57BL; Mice, Knockout; Signal Transduction; Th17 Cells; Uvea; Uveitis | 2020 |
DZNep attenuates allergic airway inflammation in an ovalbumin-induced murine model.
Topics: Adenosine; Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Hypersensitivity; Inflammation; Lung; Mice; Mice, Inbred BALB C; Ovalbumin | 2021 |
Ticagrelor alleviates sepsis-induced myocardial injury via an adenosine-dependent pathway in a mouse sepsis model.
Topics: Adenosine; Animals; Apoptosis; Disease Models, Animal; Mice; Sepsis; Ticagrelor | 2020 |
Histone H3K27 methyltransferase EZH2 and demethylase JMJD3 regulate hepatic stellate cells activation and liver fibrosis.
Topics: Adenosine; Animals; Apoptosis; Benzazepines; Bile Ducts; Carbon Tetrachloride; Cell Cycle; Cell Cycle Proteins; Cell Line; Cell Proliferation; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Hepatic Stellate Cells; Humans; Indoles; Interleukin-10; Jumonji Domain-Containing Histone Demethylases; Ligation; Liver; Liver Cirrhosis; Mice; Pyridones; Pyrimidines; Rats; RNA Interference | 2021 |
N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimer's disease.
Topics: Adenosine; Aging; Alzheimer Disease; Animals; Brain; Disease Models, Animal; Drosophila; Drosophila Proteins; Humans; Methylation; Methyltransferases; Mice; Neurodegenerative Diseases; RNA Stability | 2021 |
A muscle growth-promoting treatment based on the attenuation of activin/myostatin signalling results in long-term testicular abnormalities.
Topics: Activin Receptors, Type II; Adenosine; Animals; Body Weight; Computational Biology; Cytoskeleton; Disease Models, Animal; Gene Expression Profiling; Genome-Wide Association Study; Humans; Inhibin-beta Subunits; Ligands; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Myostatin; Organ Size; Phenotype; Principal Component Analysis; Signal Transduction; Testis; Time Factors | 2021 |
Novel Guidewire Design and Coating for Continuous Delivery of Adenosine During Interventional Procedures.
Topics: Adenosine; Animals; Coated Materials, Biocompatible; Coronary Artery Disease; Coronary Vessels; Disease Models, Animal; Drug Delivery Systems; Equipment Design; Female; Humans; Male; Percutaneous Coronary Intervention; Swine; Vasodilator Agents | 2021 |
Therapeutic cardiac arrest as an adjunct to resuscitative endovascular balloon occlusion of the aorta: Bridging the gap from fatal hemorrhage to definitive surgical control in swine.
Topics: Adenosine; Animals; Aorta; Balloon Occlusion; Cardioplegic Solutions; Cardiovascular Agents; Disease Models, Animal; Endovascular Procedures; Exsanguination; Heart Arrest, Induced; Hemostasis, Surgical; Lidocaine; Magnesium; Pharmaceutical Solutions; Preoperative Care; Resuscitation; Swine | 2021 |
Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models.
Topics: Adenosine; Animals; Antiviral Agents; Cells, Cultured; Chlorocebus aethiops; COVID-19; COVID-19 Drug Treatment; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Male; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship | 2022 |
LINC00460/DHX9/IGF2BP2 complex promotes colorectal cancer proliferation and metastasis by mediating HMGA1 mRNA stability depending on m6A modification.
Topics: Adenosine; Adult; Aged; Animals; Cell Line, Tumor; Cell Movement; Colorectal Neoplasms; DEAD-box RNA Helicases; Disease Models, Animal; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; HMGA1a Protein; Humans; Male; Mice; Middle Aged; Neoplasm Proteins; Neoplasm Staging; Prognosis; Protein Binding; RNA Stability; RNA-Binding Proteins; RNA, Long Noncoding | 2021 |
Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific
Topics: Adenosine; Animals; Celiac Disease; Cell Line; Disease Models, Animal; Epithelial Cells; Exportin 1 Protein; HLA-DQ Antigens; Humans; Intestinal Mucosa; Karyopherins; Methylation; Mice, Knockout; NF-kappa B; Polymorphism, Single Nucleotide; Receptors, Cytoplasmic and Nuclear; RNA | 2022 |
Adenosine A
Topics: Adenosine; Animals; Cognition; Disease Models, Animal; Fragile X Mental Retardation Protein; Fragile X Syndrome; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, Adenosine A2A | 2021 |
Evaluation of adenosine A1 receptor agonists as neuroprotective countermeasures against Soman intoxication in rats.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Anticonvulsants; Behavior, Animal; Brain; Deoxyadenosines; Disease Models, Animal; Male; Neuroprotective Agents; Organophosphate Poisoning; Rats, Sprague-Dawley; Receptor, Adenosine A1; Seizures; Soman | 2021 |
Electrophysiological signatures of acute systemic lipopolysaccharide-induced inflammation: potential implications for delirium science.
Topics: Adenosine; Age Factors; Animals; Caffeine; Cerebral Cortex; Cytokines; Delirium; Disease Models, Animal; Electroencephalography; Electrophysiological Phenomena; Humans; Inflammation; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Piroxicam; Prostaglandins; Wakefulness | 2021 |
Downregulation of lncRNA ZNF582-AS1 due to DNA hypermethylation promotes clear cell renal cell carcinoma growth and metastasis by regulating the N(6)-methyladenosine modification of MT-RNR1.
Topics: Adenosine; Animals; Carcinoma, Renal Cell; Cell Line, Tumor; Disease Models, Animal; DNA Methylation; Down-Regulation; Humans; Kidney Neoplasms; Kruppel-Like Transcription Factors; Mice; Mice, Nude; Middle Aged; Neoplasm Metastasis; RNA, Antisense; RNA, Long Noncoding; RNA, Ribosomal; Transfection | 2021 |
RNA m6A reader IMP2/IGF2BP2 promotes pancreatic β-cell proliferation and insulin secretion by enhancing PDX1 expression.
Topics: Adenosine; Animals; Cell Line; Cell Proliferation; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Gene Knockout Techniques; Homeodomain Proteins; Humans; Insulin Secretion; Insulin-Secreting Cells; Insulin, Regular, Human; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Promoter Regions, Genetic; Rats; RNA-Binding Proteins; RNA, Messenger; Signal Transduction; Trans-Activators; Transfection | 2021 |
Molecular Mechanisms of Adenosine Stress T1 Mapping.
Topics: Adenosine; Animals; Coronary Artery Disease; Coronary Circulation; Coronary Vessels; Disease Models, Animal; Magnetic Resonance Imaging, Cine; Mice; Myocardial Perfusion Imaging; Vasodilator Agents | 2021 |
Impaired airway epithelial barrier integrity was mediated by PI3Kδ in a mouse model of lipopolysaccharide-induced acute lung injury.
Topics: Acute Lung Injury; Adenine; Adenosine; Animals; Bronchoalveolar Lavage Fluid; Cadherins; Class I Phosphatidylinositol 3-Kinases; Claudins; Cytokines; Disease Models, Animal; Lipopolysaccharides; Lung; Male; Mice, Inbred BALB C; Quinazolines; Quinolines | 2021 |
Intramuscularly administered A1 adenosine receptor agonists as delayed treatment for organophosphorus nerve agent-induced Status Epilepticus.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Anticonvulsants; Brain; Deoxyadenosines; Disease Models, Animal; Drug Administration Schedule; Injections, Intramuscular; Male; Neuroprotective Agents; Norbornanes; Rats, Sprague-Dawley; Sarin; Soman; Status Epilepticus; Time Factors | 2021 |
CircPTPRA blocks the recognition of RNA N
Topics: Adenosine; Animals; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Disease Progression; Epigenesis, Genetic; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Heterografts; Humans; Immunohistochemistry; Mice; Models, Biological; Protein Binding; Receptor-Like Protein Tyrosine Phosphatases, Class 4; RNA-Binding Proteins; RNA, Circular; Urinary Bladder Neoplasms | 2021 |
A Hydrogel Strategy to Augment Tissue Adenosine to Improve Hindlimb Perfusion.
Topics: 5'-Nucleotidase; Adenosine; Animals; Cells, Cultured; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Drug Compounding; Female; Hindlimb; Humans; Hydrogels; Ischemia; Male; Maleimides; Mice, Inbred C57BL; Neutrophil Activation; Peripheral Arterial Disease; Polyethylene Glycols; Regional Blood Flow; Up-Regulation | 2021 |
A
Topics: Adenosine; Animals; Autoimmunity; Diabetes Mellitus, Type 1; Disease Models, Animal; Extracellular Traps; Lupus Erythematosus, Systemic; Lymphopenia; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Neutrophil Activation; Neutrophils; Receptor, Adenosine A1; Receptor, Adenosine A2A; RNA, Messenger; Signal Transduction; Streptozocin; Terpenes | 2021 |
METTL3 Regulates Angiogenesis by Modulating let-7e-5p and miRNA-18a-5p Expression in Endothelial Cells.
Topics: Adenosine; Animals; Cells, Cultured; Disease Models, Animal; Female; Gene Expression Regulation; Hindlimb; Human Umbilical Vein Endothelial Cells; Humans; Ischemia; Male; Methyltransferases; Mice, Inbred C57BL; MicroRNAs; Myocardial Infarction; Neovascularization, Physiologic; Signal Transduction; Thrombospondin 1 | 2021 |
METTL3 enhances the stability of MALAT1 with the assistance of HuR via m6A modification and activates NF-κB to promote the malignant progression of IDH-wildtype glioma.
Topics: Adenosine; Animals; Brain Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Disease Progression; ELAV-Like Protein 1; Female; Glioma; Heterografts; Humans; Isocitrate Dehydrogenase; Methyltransferases; Mice; Mice, Inbred BALB C; Mice, Nude; NF-kappa B; RNA, Long Noncoding; Signal Transduction | 2021 |
Postinjury treatments to make early tactical aeromedical evacuation practical for the brain after TBI.
Topics: Adenosine; Air Ambulances; Allopurinol; Amitriptyline; Animals; Brain; Brain Chemistry; Brain Injuries, Traumatic; Cytokines; Disease Models, Animal; Emergency Medical Services; Lidocaine; Magnesium; Male; Mice; Mice, Inbred C57BL; Propranolol; Rotarod Performance Test | 2021 |
CD39-mediated ATP-adenosine signalling promotes hepatic stellate cell activation and alcoholic liver disease.
Topics: 5'-Nucleotidase; Acetaldehyde; Adenosine; Adenosine Triphosphate; Animals; Antigens, CD; Apyrase; Carbon Tetrachloride; Colchicine; Cytokines; Disease Models, Animal; Ethanol; Gene Knockdown Techniques; Hepatic Stellate Cells; Humans; Liver Diseases, Alcoholic; Mice, Inbred C57BL; Primary Cell Culture; Rats; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta; Tungsten Compounds | 2021 |
Parkinsonism-like Disease Induced by Rotenone in Rats: Treatment Role of Curcumin, Dopamine Agonist and Adenosine A
Topics: Adenosine; Aged; Animals; Curcumin; Disease Models, Animal; Dopamine Agonists; Humans; Inflammation Mediators; Mice; Neuroprotective Agents; Parkinson Disease; Parkinsonian Disorders; Rats; Receptor, Adenosine A2A; Rotenone | 2022 |
Optical control of adenosine A
Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Disease Models, Animal; Interleukin-23; Ligands; Photochemotherapy; Psoriasis; Receptor, Adenosine A3; Signal Transduction; Skin | 2021 |
Ketogenic Diet Decreases Alcohol Intake in Adult Male Mice.
Topics: Adenosine; Alcohol Drinking; Alcoholism; Animals; Cannabinoids; Diet, Ketogenic; Disease Models, Animal; Dopamine; Eating; Ethanol; Gene Expression; Male; Mice; Motivation | 2021 |
Adenosine A2a receptors modulate TrkB receptor-dependent respiratory plasticity in neonatal rats.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Animals, Newborn; Brain Stem; Disease Models, Animal; Flavones; Neuronal Plasticity; Phenethylamines; Rats; Receptor, Adenosine A2A; Receptor, trkB; Respiratory Physiological Phenomena; Spinal Cord | 2021 |
Combatting ischemia reperfusion injury from resuscitative endovascular balloon occlusion of the aorta using adenosine, lidocaine and magnesium: A pilot study.
Topics: Adenosine; Animals; Anti-Inflammatory Agents; Aorta; Balloon Occlusion; Disease Models, Animal; Drug Therapy, Combination; Endovascular Procedures; Hydrogen-Ion Concentration; Lactic Acid; Lidocaine; Magnesium; Protective Agents; Reperfusion Injury; Resuscitation; Shock, Hemorrhagic; Swine; Treatment Outcome | 2021 |
Interaction of tau with HNRNPA2B1 and N
Topics: Adenosine; Aged; Aged, 80 and over; Alzheimer Disease; Animals; Case-Control Studies; Cerebral Cortex; Disease Models, Animal; Disease Progression; Female; HEK293 Cells; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Humans; Male; Methylation; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Protein Aggregates; Protein Aggregation, Pathological; RNA; RNA Processing, Post-Transcriptional; Severity of Illness Index; tau Proteins | 2021 |
The adenosine generating enzymes CD39/CD73 control microglial processes ramification in the mouse brain.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Triphosphate; Animals; Animals, Newborn; Antigens, CD; Apyrase; Brain; Brain Injuries; Cell Count; Cells, Cultured; Chemotaxis; Dipyridamole; Disease Models, Animal; Equilibrative Nucleoside Transporter 1; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microglia; Phenotype; Receptors, Purinergic P2Y12 | 2017 |
Adenosine Formed by CD73 on T Cells Inhibits Cardiac Inflammation and Fibrosis and Preserves Contractile Function in Transverse Aortic Constriction-Induced Heart Failure.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Triphosphate; Animals; Aorta; Collagen; Constriction; Disease Models, Animal; Fibrosis; Heart Failure; Inflammation; Interleukin-3; Male; Mice; Mice, Knockout; Signal Transduction; T-Lymphocytes | 2017 |
Nitrobenzylthioinosine mimics adenosine to attenuate the epileptiform discharge of hippocampal neurons from epileptic rats.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Disease Models, Animal; Epilepsy; Gene Expression; Hippocampus; Male; Patch-Clamp Techniques; Protein Transport; Pyramidal Cells; Rats; Receptor, Adenosine A1; Thioinosine | 2017 |
Ischemic preconditioning with a ketogenic diet improves brain ischemic tolerance through increased extracellular adenosine levels and hypoxia-inducible factors.
Topics: Adenosine; Animals; Basic Helix-Loop-Helix Transcription Factors; Brain; Brain Ischemia; Cell Line, Tumor; Cerebrovascular Circulation; Diet, Ketogenic; Disease Models, Animal; Extracellular Space; Hypoxia-Inducible Factor 1, alpha Subunit; Ischemic Preconditioning; Male; MAP Kinase Signaling System; Mice, Inbred BALB C; Neuroprotection; Phosphorylation; Proto-Oncogene Proteins c-akt; Random Allocation; Receptor, Adenosine A1; Vascular Endothelial Growth Factor A | 2017 |
A Multifunctional Biocompatible Drug Candidate is Highly Effective in Delaying Pathological Signs of Alzheimer's Disease in 5XFAD Mice.
Topics: Adenosine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Animals, Newborn; Antipsychotic Agents; Biocompatible Materials; Cells, Cultured; Cerebral Cortex; Copper; Disease Models, Animal; L-Lactate Dehydrogenase; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Phenothiazines; Platelet Aggregation; Presenilin-1; Zinc | 2017 |
Adenosine A
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adult; Aged; Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Disease Models, Animal; Female; Glycogen Synthase Kinase 3 beta; Glycogen Synthase Kinases; Hippocampus; Humans; Indoles; Isoquinolines; Male; Maleimides; Mice; Mice, Knockout; Middle Aged; Neurons; Phenethylamines; Phosphorylation; Protein Kinase Inhibitors; Receptor, Adenosine A2A; Signal Transduction; Sulfonamides; tau Proteins; Triazines; Triazoles | 2017 |
Increased activity of vascular adenosine deaminase in atherosclerosis and therapeutic potential of its inhibition.
Topics: Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Aorta; Apolipoproteins E; Atherosclerosis; Cells, Cultured; Disease Models, Animal; Fluorescent Antibody Technique; Humans; Male; Mice; Mice, Inbred C57BL; Pentostatin; Receptors, LDL | 2016 |
Critical Role of P2Y
Topics: Adenosine; Animals; Autoimmune Diseases; Cell Differentiation; Cells, Cultured; Clopidogrel; Colitis; Diabetes Mellitus, Experimental; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Gene Expression Regulation; Interleukin-17; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Knockout; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Signal Transduction; Th17 Cells; Ticagrelor; Ticlopidine; Trinitrobenzenesulfonic Acid | 2017 |
3% NaCl adenosine, lidocaine, Mg2+ (ALM) bolus and 4 hours "drip" infusion reduces noncompressible hemorrhage by 60% in a rat model.
Topics: Adenosine; Animals; Disease Models, Animal; Drug Therapy, Combination; Echocardiography; Heart; Hemodynamics; Hemorrhage; Infusions, Intravenous; Injections, Intravenous; Liver; Magnesium; Male; Rats; Rats, Sprague-Dawley; Saline Solution, Hypertonic; Shock, Hemorrhagic | 2017 |
Immunotherapy Targeting Adenosine Synthase A Decreases Severity of Staphylococcus aureus Infection in Mouse Model.
Topics: Adenosine; Animals; Anti-Bacterial Agents; Antibodies, Bacterial; Bacterial Proteins; Disease Models, Animal; Female; Immunization, Passive; Immunotherapy; Ligases; Mice; Mice, Inbred BALB C; Rabbits; Staphylococcal Skin Infections; Staphylococcus aureus | 2017 |
Combined BTK and PI3Kδ Inhibition with Acalabrutinib and ACP-319 Improves Survival and Tumor Control in CLL Mouse Model.
Topics: Adenosine; Agammaglobulinaemia Tyrosine Kinase; Animals; Apoptosis; B-Lymphocytes; Benzamides; Cell Line, Tumor; Cell Proliferation; Class Ia Phosphatidylinositol 3-Kinase; Disease Models, Animal; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Mice; Neoplasm Proteins; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrazines; Quinolines; Tumor Microenvironment | 2017 |
Liver graft preservation using perfluorocarbon improves the outcomes of simulated donation after cardiac death liver transplantation in rats.
Topics: Adenosine; Allografts; Allopurinol; Animals; Disease Models, Animal; Fluorocarbons; Glutathione; Graft Survival; Humans; Insulin; Liver; Liver Function Tests; Liver Transplantation; Male; Organ Preservation; Organ Preservation Solutions; Perfusion; Postoperative Period; Raffinose; Rats; Rats, Inbred Lew; Reperfusion Injury; Survival Rate; Time Factors; Treatment Outcome; Warm Ischemia | 2017 |
Immune-inflammatory activation after a single laparotomy in a rat model: effect of adenosine, lidocaine and Mg
Topics: Adenosine; Alkalosis, Respiratory; Animals; Blood Coagulation; Blood Platelets; Complex Mixtures; Disease Models, Animal; Fibrinolysis; Humans; Immunity, Innate; Inflammation; Infusions, Intravenous; Interleukin-10; Interleukin-6; Laparotomy; Lidocaine; Magnesium; Male; Neutrophils; Postoperative Complications; Rats; Rats, Sprague-Dawley | 2017 |
Evaluation of silybum marinaum efficacy on University of Wisconsin and histidine-tryptophan-ketoglutarate solutions latter the damage of the perfused liver.
Topics: Adenosine; Allopurinol; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Glucose; Glutathione; Immunohistochemistry; Insulin; Male; Mannitol; Organ Preservation Solutions; Potassium Chloride; Procaine; Protective Agents; Raffinose; Rats; Rats, Wistar; Silymarin | 2017 |
Expression of CD73 slows down migration of skin dendritic cells, affecting the sensitization phase of contact hypersensitivity reactions in mice.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Triphosphate; Animals; Antigens, Surface; Cell Movement; Cells, Cultured; Dendritic Cells; Dermatitis, Allergic Contact; Disease Models, Animal; GPI-Linked Proteins; Haptens; Interferon-gamma; Lectins, C-Type; Lymph Nodes; Mannose-Binding Lectins; Mice; Mice, Inbred C57BL; Mice, Knockout; Picryl Chloride; Skin; T-Lymphocytes | 2017 |
Ischemic preconditioning vs adenosine vs prostaglandin E1 for protection against liver ischemia/reperfusion injury.
Topics: Adenosine; Alprostadil; Animals; Chinchilla; Disease Models, Animal; Female; Ischemic Preconditioning; Liver; Liver Diseases; Male; Reperfusion Injury | 2017 |
m
Topics: Adenosine; Adoptive Transfer; Animals; Cell Differentiation; Cell Proliferation; Colitis; Disease Models, Animal; DNA-Binding Proteins; Female; Homeostasis; Interleukin-7; Male; Methylation; Methyltransferases; Mice; RNA Stability; RNA, Messenger; Signal Transduction; STAT5 Transcription Factor; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; T-Lymphocytes | 2017 |
The Effects of Adenosinergic Modulation on Cytokine Levels in a Pentylenetetrazole-Induced Generalized Tonic-Clonic Seizure Model.
Topics: Adenosine; Animals; Brain; Caffeine; Central Nervous System Stimulants; Convulsants; Cytokines; Disease Models, Animal; Drug Interactions; Male; Pentylenetetrazole; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Seizures | 2017 |
Role of mast cells in bronchial contraction in nonallergic obstructive lung pathology.
Topics: Adenosine; Animals; Bronchi; Bronchial Hyperreactivity; Bronchoconstriction; Cell Degranulation; Cromolyn Sodium; Disease Models, Animal; Histamine; In Vitro Techniques; Male; Mast Cells; Myocytes, Smooth Muscle; Pulmonary Disease, Chronic Obstructive; Rats, Wistar; Receptors, Purinergic P1 | 2017 |
Attenuation of pentylenetrazole-induced acute status epilepticus in rats by adenosine involves inhibition of the mammalian target of rapamycin pathway.
Topics: Adenosine; Adenylate Kinase; Animals; Anticonvulsants; Blotting, Western; Disease Models, Animal; Enzyme Inhibitors; Hippocampus; Immunohistochemistry; Male; Pentylenetetrazole; Rats, Wistar; Signal Transduction; Status Epilepticus; TOR Serine-Threonine Kinases | 2017 |
Electroacupuncture Attenuates Induction of Inflammatory Pain by Regulating Opioid and Adenosine Pathways in Mice.
Topics: Adenosine; Analgesics, Opioid; Animals; Astrocytes; Cyclooxygenase 2; Disease Models, Animal; Electroacupuncture; Ganglia, Spinal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hyperalgesia; Inflammation; Mice; NF-kappa B; Pain; Pain Management; Protein Kinase C-epsilon; Rats; Receptor for Advanced Glycation End Products; S100 Calcium Binding Protein beta Subunit; Signal Transduction; Spinal Cord Dorsal Horn | 2017 |
The antiviral drug tenofovir, an inhibitor of Pannexin-1-mediated ATP release, prevents liver and skin fibrosis by downregulating adenosine levels in the liver and skin.
Topics: Adenosine; Adenosine Triphosphate; Animals; Antiviral Agents; Connexins; Disease Models, Animal; Dose-Response Relationship, Drug; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Skin; Skin Diseases; Tenofovir | 2017 |
Opposing effects of bronchopulmonary C-fiber subtypes on cough in guinea pigs.
Topics: Action Potentials; Adenosine; Animals; Bradykinin; Citric Acid; Cough; Disease Models, Animal; Guinea Pigs; Histamine; Male; Nerve Fibers, Unmyelinated; Nodose Ganglion; Purinergic P1 Receptor Agonists; Reflex; Respiratory Rate; Serotonin; Serotonin 5-HT3 Receptor Agonists; Trachea | 2018 |
Changes of adenosinergic system in piglets fed a diet co-contaminated by mycotoxin and their effects on the regulation of adenosine.
Topics: Adenosine; Adenosine Deaminase; Aflatoxins; Animal Feed; Animals; Blood Chemical Analysis; Body Weight; Diet; Disease Models, Animal; Food Contamination; Fumonisins; Male; Mycotoxins; Swine; Weaning; Weight Gain; Zinc | 2018 |
Adenosine Production by Biomaterial-Supported Mesenchymal Stromal Cells Reduces the Innate Inflammatory Response in Myocardial Ischemia/Reperfusion Injury.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Animals; Cells, Cultured; Coculture Techniques; Disease Models, Animal; Enzyme Inhibitors; GPI-Linked Proteins; Humans; Hydrogen Peroxide; Immunity, Innate; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Neutrophils; Rats, Sprague-Dawley; Recovery of Function; Stem Cell Niche; Tissue Scaffolds | 2018 |
Vascular endothelial cell changes in postcardiac surgery acute kidney injury.
Topics: Acute Kidney Injury; Adenosine; Animals; Antigens, CD; Cadherins; Capillary Permeability; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Disease Models, Animal; Endothelial Cells; Female; Glomerular Filtration Rate; Glycocalyx; Glycosaminoglycans; Kidney; Microcirculation; Renal Circulation; Sus scrofa; Thrombomodulin | 2018 |
The Optimal PEG for Kidney Preservation: A Preclinical Porcine Study.
Topics: Adenosine; Adenosine Triphosphate; Allopurinol; Animals; Cell Hypoxia; Disease Models, Animal; Endothelial Cells; Glutathione; Insulin; Kidney; Kidney Function Tests; Kidney Transplantation; Male; Molecular Weight; Organ Preservation; Organ Preservation Solutions; Polyethylene Glycols; Primary Cell Culture; Raffinose; Recovery of Function; Reperfusion Injury; Swine; Transplantation, Autologous | 2018 |
The protective effect of pentoxifylline versus silymarin on the pancreas through increasing adenosine by CD39 in a rat model of liver cirrhosis: Pharmacological, biochemical and histological study.
Topics: Adenosine; Amylases; Animals; Antigens, CD; Apyrase; Disease Models, Animal; Insulin-Secreting Cells; Liver; Liver Cirrhosis, Experimental; Liver Function Tests; Male; Pancreas; Pentoxifylline; Protective Agents; Rats; Rats, Wistar; Silymarin; Transforming Growth Factor beta1 | 2018 |
Adenosine has two faces: Regionally dichotomous adenosine tone in a model of epilepsy with comorbid sleep disorders.
Topics: Adenosine; Animals; Comorbidity; Disease Models, Animal; Epilepsy; Excitatory Postsynaptic Potentials; Female; Hippocampus; Male; Mice; Mice, Inbred C3H; Mice, Knockout; Organ Culture Techniques; Sleep Wake Disorders | 2018 |
Impaired cerebral microcirculation induced by ammonium chloride in rats is due to cortical adenosine release.
Topics: Adenosine; Administration, Topical; Ammonium Chloride; Animals; Arterioles; Blood Flow Velocity; Cerebral Cortex; Cerebrovascular Circulation; Disease Models, Animal; Hepatic Encephalopathy; Humans; Hyperammonemia; Liver Failure, Acute; Male; Microcirculation; Rats; Rats, Wistar; Vasodilation | 2018 |
A novel method for studying airway hyperresponsiveness in allergic guinea pigs in vivo using the PreciseInhale system for delivery of dry powder aerosols.
Topics: Adenosine; Adenosine Monophosphate; Aerosols; Animals; Bronchoconstriction; Disease Models, Animal; Guinea Pigs; Lung; Male; Nebulizers and Vaporizers; Particle Size; Powders; Purinergic P1 Receptor Agonists; Respiratory Hypersensitivity | 2018 |
DZNep inhibits H3K27me3 deposition and delays retinal degeneration in the rd1 mice.
Topics: Adenosine; Amino Acid Motifs; Animals; Calpain; Disease Models, Animal; Epigenesis, Genetic; Female; Histones; Humans; Lysine; Male; Methylation; Mice; Mice, Inbred ICR; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Retina; Retinal Degeneration | 2018 |
Purinergic signaling as potential target of thiamethoxam-induced neurotoxicity using silver catfish (Rhamdia quelen) as experimental model.
Topics: Adenosine; Adenosine Triphosphate; Animals; Brain; Catfishes; Disease Models, Animal; Fish Proteins; Neurotoxicity Syndromes; Signal Transduction; Thiamethoxam | 2018 |
Deep Vein Thrombosis Exhibits Characteristic Serum and Vein Wall Metabolic Phenotypes in the Inferior Vena Cava Ligation Mouse Model.
Topics: Acetylcarnitine; Adenosine; Animals; Biomarkers; Chromatography, Liquid; Disease Models, Animal; Energy Metabolism; Magnetic Resonance Spectroscopy; Metabolomics; Mice; Sphingomyelins; Statistics as Topic; Succinic Acid; Vena Cava, Inferior; Venous Thrombosis | 2018 |
Adenosine, lidocaine, and Mg2+ (ALM) resuscitation fluid protects against experimental traumatic brain injury.
Topics: Adenosine; Animals; Brain Injuries, Traumatic; Disease Models, Animal; Disease Progression; Fluid Therapy; Lidocaine; Magnesium; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Resuscitation | 2018 |
T
Topics: Adenosine; Animals; Coronary Vessels; Disease Models, Animal; Female; Fractional Flow Reserve, Myocardial; Male; Myocardial Ischemia; Myocardial Perfusion Imaging; Positron-Emission Tomography; Reproducibility of Results; Sensitivity and Specificity; Swine; Vasodilator Agents | 2018 |
Adenosine Augmentation Evoked by an ENT1 Inhibitor Improves Memory Impairment and Neuronal Plasticity in the APP/PS1 Mouse Model of Alzheimer's Disease.
Topics: Adenosine; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Astrocytes; Cerebral Cortex; Cognitive Dysfunction; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Equilibrative Nucleoside Transporter 1; Glycogen Synthase Kinase 3 beta; Hippocampus; Memory Disorders; Mice, Transgenic; Neuronal Plasticity; Plaque, Amyloid; Presenilin-1; Receptor, Adenosine A2A; Synaptic Transmission | 2018 |
Adenosine and Adenosine 5'-triphosphate Catabolism in Systemic Blood as a Potential Biomarker for Doxorubicin Cardiotoxicity in an Experimental Rat Model in vivo.
Topics: Adenosine; Animals; Biomarkers; Cardiotoxicity; Disease Models, Animal; Doxorubicin; Male; Polyphosphates; Rats; Rats, Sprague-Dawley | 2018 |
Spectrum of activity testing for therapeutics against all four dengue virus serotypes in AG129 mouse models: Proof-of-concept studies with the adenosine nucleoside inhibitor NITD-008.
Topics: Adenosine; Animals; Antiviral Agents; Dengue Virus; Disease Models, Animal; Drug Evaluation, Preclinical; Mice; Nucleic Acid Synthesis Inhibitors; Proof of Concept Study; Serogroup; Severe Dengue | 2018 |
Behavioral changes induced through adenosine A2A receptor ligands in a rat depression model induced by olfactory bulbectomy.
Topics: Adenosine; Anhedonia; Animals; Antidepressive Agents; Behavior, Animal; Depressive Disorder, Major; Disease Models, Animal; Ligands; Male; Olfactory Bulb; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Treatment Outcome | 2018 |
Dynamic Changes of Astrocytes and Adenosine Signaling in Rat Hippocampus in Post-status Epilepticus Model of Epileptogenesis.
Topics: Adenosine; Adenosine Kinase; Animals; Astrocytes; Disease Models, Animal; Glial Fibrillary Acidic Protein; Hippocampus; Male; Rats, Sprague-Dawley; Receptors, Purinergic P1; Signal Transduction; Status Epilepticus | 2018 |
Extracellular Purine Metabolism Is the Switchboard of Immunosuppressive Macrophages and a Novel Target to Treat Diseases With Macrophage Imbalances.
Topics: Adenosine; Animals; Arthritis, Rheumatoid; Cell Differentiation; Cell Proliferation; Disease Models, Animal; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunosuppressive Agents; Inflammation; Macrophage Colony-Stimulating Factor; Macrophages; Male; Methotrexate; Mice; Monocytes; Purines; Synovial Fluid | 2018 |
Role of adenosine signaling in coordinating cardiomyocyte function and coronary vascular growth in chronic fetal anemia.
Topics: 5'-Nucleotidase; Adenosine; Anemia; Animals; Antigens, CD; Apyrase; Calcium Signaling; Chronic Disease; Coronary Vessels; Disease Models, Animal; Equilibrative Nucleoside Transport Proteins; Female; Fetal Diseases; Gene Expression Regulation, Developmental; Myocytes, Cardiac; Neovascularization, Physiologic; Pregnancy; Receptors, Purinergic P1; Sheep, Domestic | 2018 |
Maternal obesity aggravates the abnormality of porcine placenta by increasing N
Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Animals, Newborn; Disease Models, Animal; Female; Fetal Development; Lipid Metabolism; Obesity; Placenta; Pregnancy; Pregnancy Complications; Pregnancy, Animal; Swine; Swine Diseases | 2018 |
A single episode of binge alcohol drinking causes sleep disturbance, disrupts sleep homeostasis, and down-regulates equilibrative nucleoside transporter 1.
Topics: Adenosine; Animals; Binge Drinking; Blood Alcohol Content; Choline O-Acetyltransferase; Disease Models, Animal; Down-Regulation; Electroencephalography; Equilibrative Nucleoside Transporter 1; Ethanol; Homeostasis; Male; Mice; Mice, Inbred C57BL; RNA, Messenger; Sleep Wake Disorders; Spectrum Analysis; Time Factors; Wakefulness | 2018 |
Galidesivir limits Rift Valley fever virus infection and disease in Syrian golden hamsters.
Topics: Adenine; Adenosine; Animals; Antiviral Agents; Disease Models, Animal; Injections, Intramuscular; Injections, Intraperitoneal; Liver; Mesocricetus; Purine Nucleosides; Pyrrolidines; Rift Valley Fever; Rift Valley fever virus; Spleen; Survival Analysis; Treatment Outcome | 2018 |
Adenosine A1 receptor: A neuroprotective target in light induced retinal degeneration.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Blotting, Western; Caspase 3; Disease Models, Animal; Electroretinography; Glial Fibrillary Acidic Protein; Intravitreal Injections; Male; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptor, Adenosine A1; Retina; Retinal Degeneration; Tumor Necrosis Factor-alpha | 2018 |
Atrial natriuretic peptide modified oleate adenosine prodrug lipid nanocarriers for the treatment of myocardial infarction: in vitro and in vivo evaluation.
Topics: Adenosine; Animals; Atrial Natriuretic Factor; Cell Line; Disease Models, Animal; Drug Carriers; Drug Compounding; Drug Liberation; Injections, Intravenous; Myocardial Infarction; Myocardium; Nanomedicine; Nanoparticles; Phosphatidylethanolamines; Polyethylene Glycols; Prodrugs; Rats, Sprague-Dawley; Solubility; Technology, Pharmaceutical; Tissue Distribution | 2018 |
Methotrexate and BAFF interaction prevents immunization against TNF inhibitors.
Topics: 5'-Nucleotidase; Adenosine; Animals; Antibody Formation; Antigens, CD; Apyrase; Autoimmune Diseases; B-Cell Activating Factor; B-Lymphocytes; Disease Models, Animal; Drug Resistance; Humans; Immunization; Macaca; Methotrexate; Mice; Mice, Transgenic; Tumor Necrosis Factor-alpha | 2018 |
FTO-Dependent N
Topics: Adenosine; Adult; Aged; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Calcium Signaling; Case-Control Studies; Cell Line; Cell Proliferation; Demethylation; Disease Models, Animal; Female; Heart Failure; Humans; Male; Mice; Mice, Inbred C57BL; Middle Aged; Myocardial Infarction; Myocytes, Cardiac; Rats, Sprague-Dawley; Regeneration; RNA Processing, Post-Transcriptional; RNA Stability; RNA, Messenger; Sus scrofa; Ventricular Function, Left; Ventricular Remodeling | 2019 |
Left ventricular dysfunction after two hours of polarizing or depolarizing cardioplegic arrest in a porcine model.
Topics: Adenosine; Animals; Cardioplegic Solutions; Cardiopulmonary Bypass; Disease Models, Animal; Heart Arrest, Induced; Magnesium; Potassium; Propanolamines; Swine; Ventricular Dysfunction, Left | 2019 |
Purinergic signalling displays a pro-inflammatory profile in spleen and splenic lymphocytes of Rhamdia quelen fed with a diet contaminated by fungal mycotoxin: Involvement on disease pathogenesis.
Topics: Adenosine; Adenosine Triphosphate; Aflatoxin B1; Animal Feed; Animals; Antigens, CD; Apyrase; Catfishes; Diet; Disease Models, Animal; Fish Diseases; Food Contamination; Fungi; Immunotoxins; Lymphocytes; Nucleotidases; Spleen | 2018 |
Fragile X mental retardation protein modulates the stability of its m6A-marked messenger RNA targets.
Topics: Adenosine; Animals; Cerebral Cortex; Disease Models, Animal; Epigenomics; Fragile X Mental Retardation Protein; Fragile X Syndrome; Gene Expression Regulation; Genome; Humans; Mice; Proteolysis; RNA-Binding Proteins; RNA, Messenger; Transcriptome | 2018 |
An integrated metabolomic strategy for the characterization of the effects of Chinese yam and its three active components on septic cardiomyopathy.
Topics: Adenosine; Allantoin; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arbutin; Biomarkers; Cardiomyopathies; Cardiotonic Agents; China; Dietary Supplements; Dioscorea; Disease Models, Animal; Energy Metabolism; Female; Immunologic Factors; Male; Metabolomics; Plant Extracts; Plant Tubers; Principal Component Analysis; Random Allocation; Rats, Wistar; Sepsis | 2018 |
Cardiotrophin-1 Improves Kidney Preservation, Graft Function, and Survival in Transplanted Rats.
Topics: Adenosine; Allografts; Allopurinol; Animals; Cold Ischemia; Cytokines; Disease Models, Animal; Glutathione; Graft Survival; Humans; Insulin; Kidney; Kidney Function Tests; Kidney Transplantation; Male; Nephrectomy; Organ Preservation; Organ Preservation Solutions; Perfusion; Raffinose; Rats; Rats, Inbred F344; Reperfusion Injury; Tissue and Organ Harvesting | 2018 |
Coordination of ENT2-dependent adenosine transport and signaling dampens mucosal inflammation.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Biopsy; Colitis, Ulcerative; Colon; Crohn Disease; Dextran Sulfate; Disease Models, Animal; Equilibrative Nucleoside Transporter 1; Equilibrative-Nucleoside Transporter 2; Female; Humans; Intestinal Mucosa; Male; Mice; Mice, Knockout; Receptor, Adenosine A2B; Signal Transduction | 2018 |
Targeting enhancer of zeste homolog 2 protects against acute kidney injury.
Topics: Acute Kidney Injury; Adenosine; Adherens Junctions; Animals; Apoptosis; Cadherins; Cells, Cultured; Disease Models, Animal; Enhancer of Zeste Homolog 2 Protein; Epithelial Cells; Folic Acid; Hydrogen Peroxide; Jumonji Domain-Containing Histone Demethylases; Kidney; Kidney Tubules; Lipocalin-2; Male; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Phosphatidylethanolamine Binding Protein; Phosphorylation; Proto-Oncogene Proteins c-raf; Reperfusion Injury; Tissue Inhibitor of Metalloproteinase-2; Tissue Inhibitor of Metalloproteinase-3; Zonula Occludens-1 Protein | 2018 |
Production of Extracellular Adenosine by CD73
Topics: 5'-Nucleotidase; Adenosine; Animals; Cells, Cultured; Dendritic Cells; Dermatitis, Allergic Contact; Disease Models, Animal; Flow Cytometry; GPI-Linked Proteins; Immune Tolerance; Mice; Mice, Knockout; Random Allocation; Real-Time Polymerase Chain Reaction; T-Lymphocytes, Regulatory | 2019 |
Late Phases of Cardioprotection During Remote Ischemic Preconditioning and Adenosine Preconditioning Involve Activation of Neurogenic Pathway.
Topics: Adenosine; Animals; Autonomic Nervous System; Creatine Kinase; Disease Models, Animal; Ganglionic Blockers; Heart; Hexamethonium; Hindlimb; Ischemic Preconditioning; Isolated Heart Preparation; L-Lactate Dehydrogenase; Myocardial Infarction; Myocardial Reperfusion Injury; Rats, Wistar; Regional Blood Flow; Therapeutic Occlusion; Time Factors | 2019 |
Selective targeting of histone modification fails to prevent graft versus host disease after hematopoietic cell transplantation.
Topics: Adenosine; Animals; Benzamides; Biphenyl Compounds; Cells, Cultured; Disease Models, Animal; Enhancer of Zeste Homolog 2 Protein; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Histone Code; Histones; Humans; Indoles; Methylation; Mice; Morpholines; Pyridones; T-Lymphocytes | 2018 |
Adenosine 2a Receptor Signal Blockade of Murine Autoimmune Arthritis via Inhibition of Pathogenic Germinal Center-Follicular Helper T Cells.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adoptive Transfer; Animals; Arthritis, Experimental; Autoantigens; Autoimmune Diseases; CD4-Positive T-Lymphocytes; Cytokines; Disease Models, Animal; Germinal Center; Glucose-6-Phosphate Isomerase; Mice; Mice, Knockout; Mice, Transgenic; Phenethylamines; Receptor, Adenosine A2A; Receptors, Antigen, T-Cell, alpha-beta; Signal Transduction; T-Lymphocytes, Helper-Inducer | 2019 |
m
Topics: Adenosine; Animals; Cell Line, Tumor; Cytomegalovirus; Disease Models, Animal; Female; Fibroblasts; Herpesviridae Infections; Host-Pathogen Interactions; Humans; Immunity, Innate; Influenza A Virus, H1N1 Subtype; Influenza, Human; Interferon Type I; Male; Methylation; Methyltransferases; Mice; Mice, Inbred ICR; Mice, Knockout; Muromegalovirus; RNA-Binding Proteins; RNA, Messenger | 2019 |
The N
Topics: Adenosine; Animals; Cells, Cultured; Disease Models, Animal; Female; Hypertrophy, Left Ventricular; Male; Methyltransferases; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac; Rats; RNA Processing, Post-Transcriptional; RNA, Messenger; Signal Transduction; Ventricular Function, Left; Ventricular Remodeling | 2019 |
Vascular extracellular adenosine metabolism in mice correlates with susceptibility to atherosclerosis.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Deaminase; Analysis of Variance; Animals; Apolipoproteins E; Atherosclerosis; Blood Glucose; Blood Vessels; Disease Models, Animal; Hypercholesterolemia; Lipids; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Nucleotides; Receptors, LDL | 2018 |
Epitranscriptomics: Correlation of N6-methyladenosine RNA methylation and pathway dysregulation in the hippocampus of HIV transgenic rats.
Topics: Adenosine; AIDS Dementia Complex; Animals; Disease Models, Animal; Epigenesis, Genetic; Gene Expression Regulation; Hippocampus; HIV-1; Host-Pathogen Interactions; Humans; Male; Methylation; Rats; Rats, Sprague-Dawley; Rats, Transgenic; RNA Splicing; RNA, Messenger; RNA, Viral; Sequence Analysis, RNA; Transcriptome | 2019 |
CD73-derived adenosine controls inflammation and neurodegeneration by modulating dopamine signalling.
Topics: 5'-Nucleotidase; Adenosine; Animals; Disease Models, Animal; Dopamine; Dopaminergic Neurons; GPI-Linked Proteins; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Neurodegenerative Diseases; Parkinson Disease; Receptor, Adenosine A2A; Signal Transduction | 2019 |
Time-Dependent Bidirectional Neuroprotection by Adenosine 2A Receptor in Experimental Traumatic Brain Injury.
Topics: Adenosine; Animals; Brain Injuries; Brain Injuries, Traumatic; Disease Models, Animal; Male; Neuroprotection; Neuroprotective Agents; Phenethylamines; Pyrimidines; Rats, Wistar; Receptors, Purinergic P1; Signal Transduction; Time Factors; Triazoles | 2019 |
Ticagrelor Does Not Protect Isolated Rat Hearts, Thus Clouding Its Proposed Cardioprotective Role Through ENT 1 in Heart Tissue.
Topics: Adenosine; Animals; Disease Models, Animal; Equilibrative Nucleoside Transporter 1; Ischemic Preconditioning, Myocardial; Isolated Heart Preparation; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Purinergic P2Y Receptor Antagonists; Rats, Sprague-Dawley; Ticagrelor | 2019 |
Modulating P1 Adenosine Receptors in Disease Progression of SOD1
Topics: Adenosine; Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Mice, Transgenic; Microglia; Motor Neurons; Phenethylamines; Receptors, Purinergic P1; Spinal Cord; Superoxide Dismutase-1 | 2019 |
Inhibition of S-Adenosylhomocysteine Hydrolase Induces Endothelial Dysfunction via Epigenetic Regulation of p66shc-Mediated Oxidative Stress Pathway.
Topics: Adenosine; Adenosylhomocysteinase; Aged; Animals; Atherosclerosis; Coronary Artery Disease; Disease Models, Animal; DNA Methylation; Endothelium, Vascular; Epigenesis, Genetic; Female; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout, ApoE; Middle Aged; Oxidative Stress; RNA, Small Interfering; S-Adenosylhomocysteine; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1 | 2019 |
Down-Regulation of m6A mRNA Methylation Is Involved in Dopaminergic Neuronal Death.
Topics: Adenosine; Animals; Apoptosis; Brain; Cell Death; Disease Models, Animal; Dopaminergic Neurons; Down-Regulation; Epigenesis, Genetic; Male; Methylation; Oxidopamine; Parkinson Disease; PC12 Cells; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sympatholytics | 2019 |
Antisense oligonucleotide targeting CD39 improves anti-tumor T cell immunity.
Topics: Adenosine; Adenosine Triphosphate; Animals; Antineoplastic Agents, Immunological; Apyrase; Biomarkers, Tumor; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cells, Cultured; Disease Models, Animal; Gene Silencing; Humans; Immunity; Lymphocyte Activation; Mice; Neoplasms; Oligonucleotides, Antisense; T-Lymphocyte Subsets; Xenograft Model Antitumor Assays | 2019 |
Blockade pf CD73/adenosine axis improves the therapeutic efficacy of docetaxel in epithelial ovarian cancer.
Topics: Adenosine; Animals; Antigens, Neoplasm; Antineoplastic Agents; Carcinoma, Ovarian Epithelial; Disease Models, Animal; Docetaxel; Female; Humans; Mice; Tetraspanins | 2019 |
Effects of Oxygen During Long-term Hypothermic Machine Perfusion in a Porcine Model of Kidney Donation After Circulatory Death.
Topics: Adenosine; Allografts; Allopurinol; Animals; Biopsy; Disease Models, Animal; Glutathione; Humans; Hypothermia, Induced; Insulin; Kidney; Organ Preservation; Organ Preservation Solutions; Oxidative Stress; Oxygen; Perfusion; Raffinose; Reperfusion; Reperfusion Injury; Swine; Tissue and Organ Harvesting; Warm Ischemia | 2019 |
COA-Cl prevented TGF-β1-induced CTGF expression by Akt dephosphorylation in normal human dermal fibroblasts, and it attenuated skin fibrosis in mice models of systemic sclerosis.
Topics: Adenosine; Angiotensin II; Animals; Cell Line; Connective Tissue Growth Factor; Disease Models, Animal; Drug Evaluation, Preclinical; Fibroblasts; Fibrosis; Humans; Male; Mice; Phosphorylation; Proto-Oncogene Proteins c-akt; Scleroderma, Systemic; Skin; Transforming Growth Factor beta1 | 2019 |
Heterologous Antibodies Adsorption in Xenotransplantation of a Landrace Piglet Kidney Into a Rhesus Monkey.
Topics: Adenosine; Adsorption; Allopurinol; Animals; Antibodies, Heterophile; Disease Models, Animal; Female; Glutathione; Graft Rejection; Insulin; Kidney; Kidney Transplantation; Macaca mulatta; Organ Preservation Solutions; Raffinose; Swine; Tissue Donors; Transplantation, Heterologous | 2019 |
Prehospital adenosine, lidocaine, and magnesium has inferior survival compared with tactical combat casualty care resuscitation in a porcine model of prolonged hemorrhagic shock.
Topics: Adenosine; Animals; Cardioplegic Solutions; Disease Models, Animal; Emergency Medical Services; Lidocaine; Magnesium; Male; Military Medicine; Resuscitation; Shock, Hemorrhagic; Swine; Wounds and Injuries | 2019 |
Adenosine kinase inhibition protects against cisplatin-induced nephrotoxicity.
Topics: Acute Kidney Injury; Adenosine; Adenosine Kinase; Animals; Apoptosis; Cell Line; Cisplatin; Disease Models, Animal; Humans; Inflammation Mediators; Kidney; Male; Mice, Inbred C57BL; Morpholines; Oxidative Stress; Protein Kinase Inhibitors; Pyrimidines; Reactive Oxygen Species; Receptors, Purinergic P1; Signal Transduction; Up-Regulation | 2019 |
Adenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Cyclic AMP; Dipyridamole; Disease Models, Animal; Extracellular Traps; Fibrinolytic Agents; Gene Expression Regulation; Humans; Immunoglobulin G; Male; Mice; Mice, Inbred C57BL; Neutrophils; Phenethylamines; Receptor, Adenosine A2A; Signal Transduction; Vena Cava, Inferior; Venous Thrombosis | 2019 |
Abrogation of myofibroblast activities in metastasis and fibrosis by methyltransferase inhibition.
Topics: Adenosine; Animals; Breast Neoplasms; Cancer-Associated Fibroblasts; Cell Line, Tumor; Cell Transdifferentiation; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Deletion; Humans; Idiopathic Pulmonary Fibrosis; Lung Neoplasms; Methyltransferases; Mice; Myofibroblasts; Snail Family Transcription Factors; Transforming Growth Factor beta; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2019 |
Adenosine and hyaluronan promote lung fibrosis and pulmonary hypertension in combined pulmonary fibrosis and emphysema.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine Deaminase; Animals; Cell Line; Chronic Disease; Disease Models, Animal; Extracellular Matrix; Humans; Hyaluronan Synthases; Hyaluronic Acid; Idiopathic Pulmonary Fibrosis; Lung Injury; Macrophages; Mice; Pulmonary Emphysema; Receptor, Adenosine A2B | 2019 |
Cardioprotection of PLGA/gelatine cardiac patches functionalised with adenosine in a large animal model of ischaemia and reperfusion injury: A feasibility study.
Topics: Adenosine; Animals; Disease Models, Animal; Drug Implants; Female; Gelatin; Myocardial Reperfusion Injury; Myocardium; Polylactic Acid-Polyglycolic Acid Copolymer; Swine | 2019 |
Assessing the utility of antivirals for preventing maternal-fetal transmission of zika virus in pregnant mice.
Topics: Adenosine; Animals; Antiviral Agents; Disease Models, Animal; Female; Fetus; Humans; Infectious Disease Transmission, Vertical; Mice; Microcephaly; Nervous System Malformations; Pregnancy; Pregnancy Complications, Infectious; Viral Load; Zika Virus; Zika Virus Infection | 2019 |
The A
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Body Weight; Cytokines; Disease Models, Animal; Female; Graft vs Host Disease; Humans; Mice; Phenethylamines; T-Lymphocytes, Regulatory | 2019 |
Early detonation by sprouted mossy fibers enables aberrant dentate network activity.
Topics: Adenosine; Animals; CA3 Region, Hippocampal; Dentate Gyrus; Disease Models, Animal; Epilepsy; Male; Mice; Mice, Transgenic; Mossy Fibers, Hippocampal; Optogenetics; Synapses | 2019 |
Adenosine A2a receptor agonist CGS21680 treatment attenuates cardiopulmonary bypass‑associated inflammatory lung injury in juvenile rats.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Cardiopulmonary Bypass; Disease Models, Animal; Humans; Inflammation; Interleukin-1beta; Lung; Lung Injury; Peroxidase; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Tumor Necrosis Factor-alpha | 2019 |
Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Triphosphate; Animals; Antibodies, Blocking; Antigens, CD; Antineoplastic Agents; Apyrase; Cell Line, Tumor; Disease Models, Animal; Gene Knock-In Techniques; Humans; Leukocytes, Mononuclear; Melanoma; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxaliplatin; Survival Rate; T-Lymphocytes; Tumor Microenvironment | 2019 |
An E460D Substitution in the NS5 Protein of Tick-Borne Encephalitis Virus Confers Resistance to the Inhibitor Galidesivir (BCX4430) and Also Attenuates the Virus for Mice.
Topics: Adenine; Adenosine; Alleles; Amino Acid Substitution; Animals; Antiviral Agents; Cell Line; Disease Models, Animal; Drug Resistance, Microbial; Drug Resistance, Viral; Encephalitis Viruses, Tick-Borne; Encephalitis, Tick-Borne; Genotype; Mice; Mutation; Pyrrolidines; Viral Nonstructural Proteins | 2019 |
Adenosine, lidocaine, and Mg2+ fluid therapy leads to 72-hour survival after hemorrhagic shock: A model for studying differential gene expression and extending biological time.
Topics: Adenosine; Animals; Disease Models, Animal; Fluid Therapy; Gene Expression; Gene Expression Profiling; Lidocaine; Magnesium; Male; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Shock, Hemorrhagic; Time Factors | 2019 |
Lipotoxicity-associated inflammation is prevented by guarana (
Topics: Adenosine; Adenosine Triphosphate; Animals; Anti-Inflammatory Agents; Caffeine; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperlipidemias; Inflammation; Lymphocytes; Male; Rats; Rats, Wistar; Simvastatin; Theobromine; Theophylline | 2021 |
Exercise exerts an anxiolytic effect against repeated restraint stress through 5-HT
Topics: Adenosine; Animals; Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Basolateral Nuclear Complex; Brain; Depression; Depressive Disorder; Disease Models, Animal; Male; Mice; Neurons; Physical Exertion; Receptor, Adenosine A2A; Receptor, Serotonin, 5-HT2A; Restraint, Physical; Serotonin; Stress, Psychological | 2019 |
A novel AMPK activator improves hepatic lipid metabolism and leukocyte trafficking in experimental hepatic steatosis.
Topics: Adenosine; AMP-Activated Protein Kinases; Animals; Cell Adhesion; Cell Movement; Disease Models, Animal; Enzyme Activators; Fatty Liver; Hep G2 Cells; Humans; Inflammation; Leukocytes; Lipid Metabolism; Liver; Male; Mesocricetus | 2019 |
Epitranscriptomic mechanisms of N6-methyladenosine methylation regulating mammalian hypertension development by determined spontaneously hypertensive rats pericytes.
Topics: 3' Untranslated Regions; 5' Untranslated Regions; Adenosine; Animals; Disease Models, Animal; Epigenomics; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; High-Throughput Nucleotide Sequencing; Hypertension; Male; Methylation; Organ Specificity; Pericytes; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2019 |
Adenosine stress CMR perfusion imaging of the temporal evolution of perfusion defects in a porcine model of progressive obstructive coronary artery occlusion.
Topics: Adenosine; Anesthesia; Animals; Coronary Artery Disease; Disease Models, Animal; Hemodynamics; Ischemia; Magnetic Resonance Imaging; Male; Myocardial Infarction; Perfusion; Swine; Swine, Miniature; Time Factors; Ventricular Remodeling | 2019 |
Delayed administration of the nucleic acid analog 2Cl-C.OXT-A attenuates brain damage and enhances functional recovery after ischemic stroke.
Topics: Adenosine; Animals; Blotting, Western; Cerebrovascular Circulation; Disease Models, Animal; Immunohistochemistry; In Situ Nick-End Labeling; Male; MAP Kinase Signaling System; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Recovery of Function; Stroke | 2013 |
The volatile anesthetic isoflurane induces ecto-5'-nucleotidase (CD73) to protect against renal ischemia and reperfusion injury.
Topics: 5'-Nucleotidase; Acute Kidney Injury; Adenosine; Anesthetics, Inhalation; Animals; Antibodies, Neutralizing; Apoptosis; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; GPI-Linked Proteins; Humans; Isoflurane; Kidney Tubules, Proximal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Necrosis; Neutrophil Infiltration; Purinergic P1 Receptor Antagonists; Reperfusion Injury; RNA, Messenger; Time Factors; Transforming Growth Factor beta1; Volatilization | 2013 |
Adenosine A2A receptor: a target for regulating renal interstitial fibrosis in obstructive nephropathy.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Biomarkers; CD4-Positive T-Lymphocytes; Cell Movement; Disease Models, Animal; Epithelial-Mesenchymal Transition; Fibrosis; Gene Expression; Humans; Kidney; Mice; Mice, Knockout; Nephritis; Phenethylamines; Receptor, Adenosine A2A; rho-Associated Kinases; Transforming Growth Factor beta1; Ureteral Obstruction | 2013 |
Protein arginine methyltransferase 1 and 8 interact with FUS to modify its sub-cellular distribution and toxicity in vitro and in vivo.
Topics: Adenosine; Amyotrophic Lateral Sclerosis; Animals; Arginine; Cytosol; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Enzyme Inhibitors; Gene Deletion; Gene Knockdown Techniques; HEK293 Cells; Humans; Inclusion Bodies; Membrane Proteins; Methylation; Methyltransferases; Mutant Proteins; Mutation; Protein Binding; Protein Transport; Protein-Arginine N-Methyltransferases; Repressor Proteins; RNA-Binding Protein FUS; Subcellular Fractions | 2013 |
The interaction of adenosine and morphine on pentylenetetrazole-induced seizure threshold in mice.
Topics: Adenosine; Animals; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Pentylenetetrazole; Seizures; Xanthines | 2013 |
The effects of the adenosine A3 receptor agonist IB-MECA on sodium taurocholate-induced experimental acute pancreatitis.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Edema; Injections, Intraperitoneal; Lipase; Male; Necrosis; Pancreas; Pancreatic alpha-Amylases; Pancreatitis, Acute Necrotizing; Rats; Rats, Wistar; Receptor, Adenosine A3; Taurocholic Acid; Time Factors | 2013 |
The stimulatory adenosine receptor ADORA2B regulates serotonin (5-HT) synthesis and release in oxygen-depleted EC cells in inflammatory bowel disease.
Topics: Adenosine; Adult; Aged; Animals; Cell Hypoxia; Colitis; Disease Models, Animal; Enterochromaffin Cells; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Middle Aged; Oxygen; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2B; Response Elements; RNA, Messenger; Serotonin; Signal Transduction; Trinitrobenzenesulfonic Acid | 2013 |
Preclinical evaluation of transcriptional targeting strategy for human hepatocellular carcinoma in an orthotopic xenograft mouse model.
Topics: Adenosine; Animals; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Line, Tumor; Disease Models, Animal; Female; Gene Expression; Genetic Therapy; Genetic Vectors; Humans; Liver Neoplasms; Mice; Regulatory Sequences, Nucleic Acid; Transcription, Genetic; Transgenes; Xenograft Model Antitumor Assays | 2013 |
Peripheral antinociceptive action of mangiferin in mouse models of experimental pain: role of endogenous opioids, K(ATP)-channels and adenosine.
Topics: Adenosine; Adenosine Triphosphate; Analgesics; Animals; Disease Models, Animal; Mice; Opioid Peptides; Pain; Potassium Channels; Xanthones | 2013 |
Adenosine receptor expression in an experimental animal model of myocardial infarction with preserved left ventricular ejection fraction.
Topics: Adenosine; Animals; Disease Models, Animal; Gene Expression Regulation; Male; Myocardial Infarction; Myocardium; Receptors, Purinergic P1; RNA, Messenger; Stroke Volume; Sus scrofa; Time Factors; Ventricular Function, Left | 2014 |
The effects of adenocaine (adenosine and lidocaine) on early post-resuscitation cardiac and neurological dysfunction in a porcine model of cardiac arrest.
Topics: Adenosine; Animals; Brain Death; Cardiopulmonary Resuscitation; Cardiovascular Agents; Coronary Angiography; Disease Models, Animal; Drug Combinations; Heart Arrest; Hemodynamics; Lidocaine; Oxygen; Random Allocation; Reperfusion Injury; Survival Rate; Swine | 2013 |
Ticagrelor reduces neutrophil recruitment and lung damage in abdominal sepsis.
Topics: Adenosine; Animals; Blood Platelets; Chemokines, CXC; Disease Models, Animal; Lung Injury; Macrophage-1 Antigen; Male; Mice; Neutrophil Infiltration; Neutrophils; Platelet Aggregation; Pulmonary Edema; Purinergic P2Y Receptor Antagonists; Sepsis; Ticagrelor | 2014 |
Adenosine A2A receptor contributes to ischemic brain damage in newborn piglet.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Animals, Newborn; Blood Flow Velocity; Cerebrovascular Circulation; Corpus Striatum; Disease Models, Animal; Hypoxia-Ischemia, Brain; Immunohistochemistry; Laser-Doppler Flowmetry; Male; Neurons; Oxidative Stress; Phenethylamines; Pyrimidines; Receptor, Adenosine A2A; Sus scrofa; Triazoles | 2013 |
Modulation of allogeneic CD8+ T-cell response by DZNep controls GVHD while preserving hematopoietic chimerism.
Topics: Adenosine; Animals; Apoptosis; Cell Proliferation; Disease Models, Animal; Enzyme Inhibitors; Fas Ligand Protein; Female; Graft vs Host Disease; Granzymes; Hematopoietic Stem Cell Transplantation; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Immunosuppressive Agents; Interferon-gamma; Interleukin-2; Lymphocyte Activation; Male; Methylation; Mice; Mice, Inbred C3H; T-Lymphocytes, Cytotoxic; Time Factors; TNF-Related Apoptosis-Inducing Ligand; Transplantation Chimera; Transplantation Tolerance; Transplantation, Homologous; Tumor Necrosis Factor-alpha | 2013 |
Effect of adenosine A1 receptor agonist on the enhanced excitability of spinal dorsal horn neurons after peripheral nerve injury.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Analysis of Variance; Animals; Disease Models, Animal; Gene Expression Regulation; Hyperalgesia; Male; Pain Threshold; Physical Stimulation; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Tibial Neuropathy; Time Factors | 2014 |
Remote cardioprotection by transfer of coronary effluent from ischemic preconditioned rabbit heart preserves mitochondrial integrity and function via adenosine receptor activation.
Topics: Adenosine; Animals; Disease Models, Animal; Ischemic Preconditioning, Myocardial; Male; Mitochondria; Myocardial Infarction; Myocardial Reperfusion Injury; Rabbits; Reactive Oxygen Species; Receptors, Purinergic P1; Theophylline | 2014 |
The role of adenosine in preconditioning by brief pressure overload in rats.
Topics: Adenosine; Animals; Disease Models, Animal; Heart Ventricles; Hemodynamics; Ischemic Preconditioning, Myocardial; Myocardial Infarction; Rats; Rats, Sprague-Dawley | 2015 |
Caspase inhibition via A3 adenosine receptors: a new cardioprotective mechanism against myocardial infarction.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Androstadienes; Animals; Apoptosis; Butadienes; Cardiotonic Agents; Caspase 3; Disease Models, Animal; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Nitriles; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A3; Signal Transduction; Wortmannin | 2014 |
Overexpression of adenosine kinase in cortical astrocytes and focal neocortical epilepsy in mice.
Topics: Adenosine; Adenosine Kinase; Animals; Astrocytes; Cerebrovascular Circulation; Dependovirus; Disease Models, Animal; Electroencephalography; Epilepsies, Partial; Genetic Vectors; Homeostasis; Male; Mice; Mice, Inbred C57BL; Microcirculation; Neocortex | 2014 |
Myocardial CT perfusion imaging in a large animal model: comparison of dynamic versus single-phase acquisitions.
Topics: Adenosine; Animals; Area Under Curve; Contrast Media; Coronary Circulation; Coronary Stenosis; Coronary Vessels; Disease Models, Animal; Female; Iohexol; Male; Myocardial Perfusion Imaging; Predictive Value of Tests; Reproducibility of Results; ROC Curve; Severity of Illness Index; Swine; Time Factors; Tomography, X-Ray Computed; Vasodilator Agents | 2013 |
Autoregulation of retinal blood flow in response to decreased ocular perfusion pressure in cats: comparison of the effects of increased intraocular pressure and systemic hypotension.
Topics: Adenosine; Animals; Cats; Disease Models, Animal; Endothelium-Dependent Relaxing Factors; Excitatory Amino Acid Agonists; Female; Homeostasis; Hypotension; Intraocular Pressure; Intravitreal Injections; Laser-Doppler Flowmetry; Male; N-Methylaspartate; Nitric Oxide; Ocular Hypertension; Regional Blood Flow; Retina; Vasodilator Agents | 2014 |
Protective effects of the novel adenosine derivative WS0701 in a mouse model of posttraumatic stress disorder.
Topics: Adenosine; Animals; Disease Models, Animal; Hippocampus; Male; Mice; Neuroprotective Agents; Stress Disorders, Post-Traumatic | 2014 |
EZH2 down-regulation exacerbates lipid accumulation and inflammation in in vitro and in vivo NAFLD.
Topics: Adenosine; Animals; Disease Models, Animal; Down-Regulation; Enhancer of Zeste Homolog 2 Protein; Fatty Liver; Hep G2 Cells; Histones; Humans; MicroRNAs; Non-alcoholic Fatty Liver Disease; Oleic Acid; Palmitic Acid; Polycomb Repressive Complex 2; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2013 |
Assessment of peripheral skeletal muscle microperfusion in a porcine model of peripheral arterial stenosis by steady-state contrast-enhanced ultrasound and Doppler flow measurement.
Topics: Adenosine; Animals; Arterial Occlusive Diseases; Blood Flow Velocity; Blood Pressure; Contrast Media; Disease Models, Animal; Female; Heart Rate; Iliac Artery; Ischemia; Male; Microcirculation; Muscle, Skeletal; Phospholipids; Sulfur Hexafluoride; Swine; Ultrasonography | 2015 |
Low doses of the selective adenosine A2A receptor agonist CGS21680 are protective in a rat model of transient cerebral ischemia.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Blood Pressure; Body Weight; Brain Ischemia; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Gliosis; Heart Rate; Male; Motor Activity; Neuroprotective Agents; Phenethylamines; Rats; Rats, Wistar; Weight Loss | 2014 |
[Anticonvulsant and neuroprotective effects of cyclopentyladenosine on the model of convulsive status in rats].
Topics: Acrylic Resins; Adenosine; Animals; Anticonvulsants; Disease Models, Animal; Neuroprotective Agents; Rats; Seizures | 2013 |
Small-volume 7.5% NaCl adenosine, lidocaine, and Mg2+ has multiple benefits during hypotensive and blood resuscitation in the pig following severe blood loss: rat to pig translation.
Topics: Adenosine; Animals; Blood Volume; Disease Models, Animal; Drug Therapy, Combination; Female; Fluid Therapy; Hemoglobin A; Hypotension; Infusions, Intravenous; Lidocaine; Magnesium; Oxygen Consumption; Rats; Rehydration Solutions; Shock, Hemorrhagic; Sodium Chloride; Stroke Volume; Sus scrofa; Vasodilator Agents | 2014 |
Feasibility of dynamic CT-based adenosine stress myocardial perfusion imaging to detect and differentiate ischemic and infarcted myocardium in an large experimental porcine animal model.
Topics: Adenosine; Animals; Blood Flow Velocity; Coronary Angiography; Coronary Circulation; Diagnosis, Differential; Disease Models, Animal; Feasibility Studies; Myocardial Infarction; Myocardial Ischemia; Myocardial Perfusion Imaging; Predictive Value of Tests; Regional Blood Flow; Reproducibility of Results; Swine; Time Factors; Tomography, X-Ray Computed | 2014 |
Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430.
Topics: Adenine; Adenosine; Administration, Oral; Animals; Antiviral Agents; Disease Models, Animal; DNA-Directed RNA Polymerases; Ebolavirus; Filoviridae; Filoviridae Infections; Hemorrhagic Fever, Ebola; Humans; Injections, Intramuscular; Macaca fascicularis; Marburg Virus Disease; Marburgvirus; Purine Nucleosides; Pyrrolidines; RNA; Time Factors | 2014 |
Cyclodextrin curcumin formulation improves outcome in a preclinical pig model of marginal kidney transplantation.
Topics: Adenosine; Allopurinol; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Cells, Cultured; Chemistry, Pharmaceutical; Curcumin; Cyclodextrins; Disease Models, Animal; Fibrosis; Flow Cytometry; Glutathione; Graft Rejection; Humans; Inflammation; Insulin; Kidney Transplantation; Kidney Tubules; Male; Organ Preservation Solutions; Oxidative Stress; Prostate; Raffinose; Real-Time Polymerase Chain Reaction; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Swine | 2014 |
A2B adenosine receptor induces protective antihelminth type 2 immune responses.
Topics: Adenosine; Animals; Cytokines; Disease Models, Animal; Eosinophils; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Nematoda; Nematospiroides dubius; Receptor, Adenosine A2B; Strongylida Infections | 2014 |
Small molecule, big advance against Marburg virus.
Topics: Adenine; Adenosine; Animals; Antiviral Agents; Bunyaviridae; Disease Models, Animal; Filoviridae; Guinea Pigs; Humans; Macaca fascicularis; Marburg Virus Disease; Marburgvirus; Mice; Purine Nucleosides; Pyrrolidines | 2014 |
Iron-induced oxidative rat liver injury after non-heart-beating warm ischemia is mediated by tumor necrosis factor α and prevented by deferoxamine.
Topics: Adenosine; Allopurinol; Animals; Aspartate Aminotransferases; Bile; Deferoxamine; Disease Models, Animal; F2-Isoprostanes; Glutathione; Heart Arrest; Insulin; Iron; L-Lactate Dehydrogenase; Liver; Liver Diseases; Male; Malondialdehyde; Organ Preservation Solutions; Oxidative Stress; Perfusion; Raffinose; Rats; Tumor Necrosis Factor-alpha; Warm Ischemia | 2014 |
A pharmacologic activator of endothelial KCa channels enhances coronary flow in the hearts of type 2 diabetic rats.
Topics: Adenosine; Age Factors; Animals; Benzothiazoles; Bradykinin; Coronary Circulation; Coronary Vessels; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Heart; Infusion Pumps; Male; Nitroprusside; Organ Culture Techniques; Potassium Channels, Calcium-Activated; Rats; Rats, Wistar | 2014 |
Inhibitory effect of adenosine on intimal hyperplasia and proliferation of smooth muscle cells in a carotid arterial anastomosis animal model.
Topics: Adenosine; Anastomosis, Surgical; Animals; Carotid Arteries; Cell Proliferation; Disease Models, Animal; Endothelium, Vascular; Hyperplasia; Myocytes, Smooth Muscle; Neointima; Rabbits; Tunica Intima | 2015 |
Rewarming preservation by organ perfusion system for donation after cardiac death liver grafts in pigs.
Topics: Adenosine; Alanine Transaminase; Allopurinol; Animals; Aspartate Aminotransferases; Biomarkers; Cold Ischemia; Disease Models, Animal; Female; Glutathione; Graft Survival; Heart Arrest; Hepatectomy; Insulin; L-Lactate Dehydrogenase; Liver; Liver Transplantation; Necrosis; Organ Preservation; Organ Preservation Solutions; Perfusion; Raffinose; Reperfusion Injury; Rewarming; Sus scrofa; Time Factors; Tissue and Organ Harvesting; Warm Ischemia | 2014 |
Synthesis of a FTO inhibitor with anticonvulsant activity.
Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Anticonvulsants; Blotting, Western; Catalytic Domain; Disease Models, Animal; Epilepsy; HeLa Cells; Humans; Mice; MicroRNAs; Mixed Function Oxygenases; Models, Chemical; Molecular Structure; Oxo-Acid-Lyases; Proteins | 2014 |
Extracellular adenosine regulates colitis through effects on lymphoid and nonlymphoid cells.
Topics: Adenosine; Adoptive Transfer; Animals; Biomarkers; Colitis; Colon; Cytokines; Disease Models, Animal; Female; Helicobacter hepaticus; Homeodomain Proteins; Inflammation Mediators; Leukocyte Common Antigens; Lymph Nodes; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, Adenosine A2A; Severity of Illness Index; T-Lymphocyte Subsets; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Time Factors | 2014 |
Effect of the P2Y12 antagonist ticagrelor on neointimal hyperplasia in a rabbit carotid anastomosis model†.
Topics: Adenosine; Anastomosis, Surgical; Animals; Biopsy; Carotid Arteries; Carotid Stenosis; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperplasia; Immunohistochemistry; Neointima; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Rabbits; Receptors, Purinergic P2Y12; Recurrence; Ticagrelor; Transforming Growth Factor beta | 2014 |
Topical application of the adenosine A2A receptor agonist CGS-21680 prevents phorbol-induced epidermal hyperplasia and inflammation in mice.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Administration, Topical; Animals; Anti-Inflammatory Agents; Cell Proliferation; Collagen; Cytokines; Dexamethasone; Disease Models, Animal; Epidermis; Female; Hyperplasia; Inflammation; Mice; Peroxidase; Phenethylamines; Skin Diseases; Tetradecanoylphorbol Acetate | 2014 |
Role of 20-HETE in the impaired myogenic and TGF responses of the Af-Art of Dahl salt-sensitive rats.
Topics: Adenosine; Afferent Pathways; Animals; Arachidonic Acid; Arterioles; Disease Models, Animal; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Microvessels; Muscle Development; Rats; Rats, Inbred BN; Rats, Inbred Dahl; Rats, Sprague-Dawley; Regional Blood Flow; Transforming Growth Factors; Vasoconstriction | 2014 |
Severe hemorrhage attenuates cardiopulmonary chemoreflex control of regional sympathetic outputs via NTS adenosine receptors.
Topics: Adenosine; Adrenal Glands; Animals; Blood Pressure; Cardiovascular System; Chemoreceptor Cells; Disease Models, Animal; Heart Rate; Hemorrhage; Hypotension; Kidney; Male; Neural Inhibition; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptors, Serotonin, 5-HT3; Reflex; Serotonin 5-HT3 Receptor Agonists; Severity of Illness Index; Solitary Nucleus; Sympathetic Nervous System; Time Factors | 2014 |
Peripheral neurobiologic mechanisms of antiallodynic effect of warm water immersion therapy on persistent inflammatory pain.
Topics: Adenosine; Animals; Benzoxazines; Disease Models, Animal; Edema; Freund's Adjuvant; Hyperalgesia; Immersion; Indoles; Inflammation; Male; Mice; Morpholines; Naloxone; Naphthalenes; Narcotic Antagonists; Neurobiology; Pain Measurement; Receptor, Adenosine A1; Receptor, Cannabinoid, CB2; Receptors, Opioid; Water Purification | 2015 |
BCX4430, a novel nucleoside analog, effectively treats yellow fever in a Hamster model.
Topics: Adenine; Adenosine; Alanine Transaminase; Animals; Antibodies, Neutralizing; Antibodies, Viral; Antiviral Agents; Cells, Cultured; Cricetinae; Disease Models, Animal; Female; Mesocricetus; Purine Nucleosides; Pyrrolidines; Treatment Outcome; Viral Plaque Assay; Viremia; Yellow Fever; Yellow fever virus | 2014 |
Adenosine, lidocaine and Mg2+ (ALM) induces a reversible hypotensive state, reduces lung edema and prevents coagulopathy in the rat model of polymicrobial sepsis.
Topics: Adenosine; Animals; Blood Coagulation Disorders; Disease Models, Animal; Drug Therapy, Combination; Edema; Hypotension; Infusions, Intravenous; Lidocaine; Lung Diseases; Magnesium; Male; Partial Thromboplastin Time; Prothrombin Time; Rats; Rats, Sprague-Dawley; Sepsis | 2014 |
Postnatal development and LPS responsiveness of pulmonary adenosine receptor expression and of adenosine-metabolizing enzymes in mice.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Deaminase; Age Factors; Animals; Animals, Newborn; Disease Models, Animal; Gene Expression Regulation, Enzymologic; GPI-Linked Proteins; Lipopolysaccharides; Lung; Mice, Inbred C57BL; Neutrophil Infiltration; Pneumonia; Receptors, Purinergic P1; Respiratory Distress Syndrome, Newborn; RNA, Messenger | 2014 |
A3 adenosine receptor agonist prevents the development of paclitaxel-induced neuropathic pain by modulating spinal glial-restricted redox-dependent signaling pathways.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Antineoplastic Agents, Phytogenic; Cytokines; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Hyperalgesia; Male; NADP; Neuralgia; Neuroglia; NF-kappa B; Oxidation-Reduction; Paclitaxel; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord; Tumor Necrosis Factor-alpha | 2014 |
Determination of culprit coronary artery branches using hemodynamic indices from angiographic images.
Topics: Adenosine; Animals; Area Under Curve; Coronary Angiography; Coronary Stenosis; Coronary Vessels; Disease Models, Animal; Fractional Flow Reserve, Myocardial; Hemodynamics; Hyperemia; Microcirculation; Models, Cardiovascular; Predictive Value of Tests; Radiographic Image Interpretation, Computer-Assisted; ROC Curve; Severity of Illness Index; Sus scrofa; Vasodilator Agents | 2015 |
Interaction of the adenosine A1 receptor agonist N6-cyclopentyladenosine and κ-opioid receptors in rat spinal cord nociceptive reflexes.
Topics: Adenosine; Animals; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Fentanyl; Inflammation; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reflex; Spinal Cord | 2014 |
Increased plasma S-adenosylhomocysteine-accelerated atherosclerosis is associated with epigenetic regulation of endoplasmic reticulum stress in apoE-/- mice.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Binding Sites; CCAAT-Enhancer-Binding Proteins; Cell Line; Disease Models, Animal; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Regulation, Enzymologic; Heat-Shock Proteins; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Male; Methylation; Mice, Inbred C57BL; Mice, Knockout; Plaque, Atherosclerotic; Promoter Regions, Genetic; RNA Interference; RNA, Small Interfering; S-Adenosylhomocysteine; Time Factors; Up-Regulation | 2015 |
Intestinal immunopathology is associated with decreased CD73-generated adenosine during lethal infection.
Topics: 5'-Nucleotidase; Adenosine; Animals; Antigens, CD; Apyrase; Disease Models, Animal; Gene Expression; Gene Expression Regulation; Intestinal Diseases; Mice; Mice, Knockout; Receptor, Adenosine A2A; Receptor, Adenosine A2B; T-Lymphocyte Subsets; Toxoplasma; Transforming Growth Factor beta; Tretinoin | 2015 |
A novel mechanism of B cell-mediated immune suppression through CD73 expression and adenosine production.
Topics: 5'-Nucleotidase; Adenosine; Animals; Antigens, CD; Apyrase; B-Lymphocyte Subsets; Colitis; Disease Models, Animal; Gene Expression; Immunomodulation; Immunophenotyping; Interleukin-10; Male; Mice; Mice, Knockout; Models, Biological; Peritoneal Cavity; Phenotype | 2014 |
Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states.
Topics: Adenosine; Animals; Disease Models, Animal; Gene Expression Regulation; Hyperalgesia; Male; Medulla Oblongata; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morpholines; Naloxone; Neuralgia; Neurons; Pain Measurement; Pain Threshold; Purinergic P1 Receptor Antagonists; Pyridines; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A3; Spinal Cord; Time Factors | 2015 |
Recipient T cell TIM-3 and hepatocyte galectin-9 signalling protects mouse liver transplants against ischemia-reperfusion injury.
Topics: Adenosine; Allopurinol; Animals; Apoptosis; Cell Differentiation; Disease Models, Animal; Galectins; Glutathione; Hepatitis A Virus Cellular Receptor 2; Hepatocytes; Immunity, Innate; In Vitro Techniques; Insulin; Liver Transplantation; Lymphocyte Activation; Macrophages; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Neutrophils; Organ Preservation; Organ Preservation Solutions; Raffinose; Receptors, Virus; Reperfusion Injury; Signal Transduction; T-Lymphocytes | 2015 |
Inhibition of adenosine kinase attenuates inflammation and neurotoxicity in traumatic optic neuropathy.
Topics: Adenosine; Adenosine Kinase; Animals; Anti-Inflammatory Agents; Calcium-Binding Proteins; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Equilibrative Nucleoside Transporter 1; Imidazoles; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microfilament Proteins; Microglia; Morpholines; Neurotoxicity Syndromes; Nitric Oxide Synthase Type I; Optic Nerve Injuries; Oxidative Stress; Pyridines; Pyrimidines; Retina | 2014 |
Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease.
Topics: Adenosine; Animals; Autoimmune Diseases; Cells, Cultured; Class I Phosphatidylinositol 3-Kinases; Crystallography, X-Ray; Disease Models, Animal; Drug Discovery; Female; Humans; Inflammation; Mice, Inbred BALB C; Mice, Transgenic; Models, Chemical; Models, Molecular; Molecular Structure; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Quinolines; Rats, Inbred Lew; Sf9 Cells; Structure-Activity Relationship | 2015 |
Polyethylene glycol rinse solution: an effective way to prevent ischemia-reperfusion injury.
Topics: Adenosine; Allopurinol; Animals; Autophagy; Biomarkers; Cold Ischemia; Cytoprotection; Cytoskeleton; Disease Models, Animal; Glutathione; Hepatectomy; Insulin; Liver; Liver Function Tests; Male; Mitochondria, Liver; Organ Preservation; Organ Preservation Solutions; Oxidative Stress; Polyethylene Glycols; Raffinose; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Time Factors | 2014 |
Mangiferin attenuates renal ischemia-reperfusion injury by inhibiting inflammation and inducing adenosine production.
Topics: 5'-Nucleotidase; Adenosine; Animals; Apoptosis; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Gene Expression Regulation; Humans; Interleukin-1beta; Kidney; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Peroxidase; Potassium; Reperfusion Injury; Signal Transduction; Tumor Necrosis Factor-alpha | 2015 |
Modulation of adenosine signaling prevents scopolamine-induced cognitive impairment in zebrafish.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Avoidance Learning; Cognition Disorders; Dipyridamole; Disease Models, Animal; Motor Activity; Muscarinic Antagonists; Nucleoside Transport Proteins; Purinergic P1 Receptor Antagonists; Scopolamine; Signal Transduction; Social Behavior; Zebrafish | 2015 |
ENT1 inhibition attenuates epileptic seizure severity via regulation of glutamatergic neurotransmission.
Topics: Action Potentials; Adenosine; Adolescent; Adult; Animals; Anterior Temporal Lobectomy; Anticonvulsants; CA1 Region, Hippocampal; Carrier Proteins; Child, Preschool; Convulsants; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Drug Resistance; Epilepsy, Temporal Lobe; Equilibrative Nucleoside Transporter 1; Glutamates; Humans; Male; Middle Aged; Nerve Tissue Proteins; Phosphorylation; Pilocarpine; Protein Processing, Post-Translational; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Seizures; Thioinosine; Young Adult | 2015 |
Adenosine, lidocaine and Mg2+ improves cardiac and pulmonary function, induces reversible hypotension and exerts anti-inflammatory effects in an endotoxemic porcine model.
Topics: Adenosine; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Drug Therapy, Combination; Endotoxemia; Female; Heart; Hypotension; Inflammation Mediators; Lidocaine; Lung; Magnesium; Random Allocation; Respiratory Function Tests; Swine | 2014 |
Dopamine treatment of brain-dead Fisher rats improves renal histology but not early renal function in Lewis recipients after prolonged static cold storage.
Topics: Adenosine; Allopurinol; Animals; Brain Death; Cardiotonic Agents; Disease Models, Animal; Dopamine; Follow-Up Studies; Glomerular Filtration Rate; Glutathione; Insulin; Kidney; Kidney Transplantation; Male; Organ Preservation Solutions; Raffinose; Rats; Rats, Inbred F344; Rats, Inbred Lew; Tissue Donors; Transplantation, Homologous | 2014 |
Elevated placental adenosine signaling contributes to the pathogenesis of preeclampsia.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Deaminase; Adult; Animals; Autoantibodies; Disease Models, Animal; Female; Fetal Growth Retardation; Gene Deletion; Humans; Mice, Knockout; Placenta; Pre-Eclampsia; Pregnancy; Receptor, Adenosine A2B; Signal Transduction; Up-Regulation; Vascular Endothelial Growth Factor Receptor-1 | 2015 |
Adenosine derived from ecto-nucleotidases in calcific aortic valve disease promotes mineralization through A2a adenosine receptor.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Triphosphatases; Aged; Animals; Aortic Valve; Aortic Valve Stenosis; Bicuspid Aortic Valve Disease; Calcinosis; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Female; Heart Defects, Congenital; Heart Valve Diseases; Humans; Male; Mice; Mice, Knockout; Middle Aged; Phosphoric Diester Hydrolases; Pyrophosphatases; Receptor, Adenosine A2A; Signal Transduction | 2015 |
Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Cell Membrane; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Exploratory Behavior; HEK293 Cells; Hippocampus; Humans; In Vitro Techniques; Light; Memory Disorders; Mice; Mice, Inbred C57BL; Phenethylamines; Phosphorylation; Receptors, Adenosine A2; Signal Transduction; Synaptosomes; Transfection | 2015 |
The infarct-sparing effect of IB-MECA against myocardial ischemia/reperfusion injury in mice is mediated by sequential activation of adenosine A3 and A 2A receptors.
Topics: Adenosine; Animals; Disease Models, Animal; Hemodynamics; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Infarction; Myocardial Reperfusion Injury; Receptor, Adenosine A2A; Receptor, Adenosine A3 | 2015 |
CD39+ regulatory T cells attenuate allergic airway inflammation.
Topics: Adenosine; Animals; Antigens, CD; Apyrase; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Immunophenotyping; Immunosuppressive Agents; Lung; Lymphocyte Count; Mice; Mice, Knockout; Respiratory Hypersensitivity; T-Lymphocyte Subsets; T-Lymphocytes, Regulatory | 2015 |
Age-related decrease of adenosine-mediated relaxation in rat detrusor is a result of A2B receptor downregulation.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine Triphosphate; Age Factors; Aged; Aminopyridines; Animals; Disease Models, Animal; Down-Regulation; Female; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Rats; Receptor, Adenosine A2B; Urinary Bladder, Overactive | 2015 |
Immunological mechanisms of the antitumor effects of supplemental oxygenation.
Topics: Adenosine; Animals; Antineoplastic Agents; Cell Line, Tumor; Disease Models, Animal; Female; Humans; Hyperoxia; Hypoxia; Immunosuppression Therapy; Killer Cells, Natural; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Metastasis; Neoplasms; Oxygen; Remission Induction; Respiration; T-Lymphocytes, Regulatory; Tumor Microenvironment | 2015 |
An adenosine A3 receptor agonist inhibits DSS-induced colitis in mice through modulation of the NF-κB signaling pathway.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Colitis; Cytokines; Disease Models, Animal; Gene Expression; Inflammation Mediators; Intestinal Mucosa; Mice; NF-kappa B; Peroxidase; Receptor, Adenosine A3; Signal Transduction | 2015 |
Suppression of adenosine 2a receptor (A2aR)-mediated adenosine signaling improves disease phenotypes in a mouse model of amyotrophic lateral sclerosis.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Cell Differentiation; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Female; Humans; Male; Mediator Complex; Mice; Mice, Transgenic; Middle Aged; Motor Neurons; Muscle Strength; Purines; Receptor, Adenosine A2A; Signal Transduction; Spinal Cord; Superoxide Dismutase | 2015 |
Correction of acute traumatic coagulopathy with small-volume 7.5% NaCl adenosine, lidocaine, and Mg2+ occurs within 5 minutes: a ROTEM analysis.
Topics: Adenosine; Animals; Blood Coagulation Disorders; Disease Models, Animal; Hemodynamics; Lidocaine; Magnesium; Male; Partial Thromboplastin Time; Prothrombin Time; Random Allocation; Rats; Rats, Sprague-Dawley; Resuscitation; Shock, Hemorrhagic; Sodium Chloride; Thrombelastography; Time Factors | 2015 |
Translating drug-induced hibernation to therapeutic hypothermia.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Body Temperature; CA1 Region, Hippocampal; Cell Death; Disease Models, Animal; Heart Arrest; Heart Rate; Hibernation; Hypothermia, Induced; Male; Neurons; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Temperature; Theophylline | 2015 |
Engagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic pain.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Hyperalgesia; K Cl- Cotransporters; Male; Mice; Pain Threshold; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sciatica; Signal Transduction; Spinal Nerve Roots; Symporters; Thiazoles; Thioglycolates | 2015 |
Pollen-derived adenosine is a necessary cofactor for ragweed allergy.
Topics: Adenosine; Administration, Intranasal; Animals; Antigens, Plant; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Epithelial Cells; Female; Humans; Immunization; Lung; Mice; Mice, Inbred BALB C; Plant Extracts; Random Allocation; Respiratory Hypersensitivity; Risk Assessment; Sensitivity and Specificity; Th2 Cells | 2015 |
Promotion of Wound Healing by an Agonist of Adenosine A2A Receptor Is Dependent on Tissue Plasminogen Activator.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Administration, Cutaneous; Animals; Disease Models, Animal; Endothelial Cells; Histiocytes; Mice, Inbred C57BL; Mice, Knockout; Phenethylamines; Receptor, Adenosine A2A; Skin; Time Factors; Tissue Plasminogen Activator; Urokinase-Type Plasminogen Activator; Wound Healing; Wounds, Penetrating | 2015 |
Ticagrelor protects the heart against reperfusion injury and improves remodeling after myocardial infarction.
Topics: Adenosine; Administration, Oral; Animals; Apoptosis; Cardiotonic Agents; Clopidogrel; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrosis; Injections, Intraperitoneal; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Purinergic P2Y Receptor Antagonists; Rats, Sprague-Dawley; Signal Transduction; Ticagrelor; Ticlopidine; Time Factors; Ventricular Function, Left; Ventricular Remodeling | 2015 |
Melanoma Induces, and Adenosine Suppresses, CXCR3-Cognate Chemokine Production and T-cell Infiltration of Lungs Bearing Metastatic-like Disease.
Topics: Adenosine; Animals; CD8-Positive T-Lymphocytes; Chemokines; Cytokines; Disease Models, Animal; Humans; Ligands; Lung Neoplasms; Lymphocytes, Tumor-Infiltrating; Melanoma; Melanoma, Experimental; Mice, Knockout; Neoplasm Metastasis; Receptors, CXCR3; Signal Transduction; T-Lymphocytes; Tumor Burden | 2015 |
Enhanced efficacy of photodynamic therapy by inhibiting ABCG2 in colon cancers.
Topics: Adenosine; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Line, Tumor; Colonic Neoplasms; Diketopiperazines; Disease Models, Animal; Gene Expression; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Mice; Neoplasm Proteins; Photochemotherapy; RNA, Messenger; Tumor Burden; Xenograft Model Antitumor Assays | 2015 |
Ketogenic diet prevents epileptogenesis and disease progression in adult mice and rats.
Topics: Adenosine; Animals; Anticonvulsants; Diet, Ketogenic; Disease Models, Animal; Disease Progression; DNA Methylation; Hippocampus; Kindling, Neurologic; Male; Mice; Pentylenetetrazole; Pilocarpine; Random Allocation; Rats, Wistar; Seizures; Status Epilepticus; Valproic Acid | 2015 |
Extracellular Adenosine Formation by Ecto-5'-Nucleotidase (CD73) Is No Essential Trigger for Early Phase Ischemic Preconditioning.
Topics: 5'-Nucleotidase; Adenosine; Animals; Disease Models, Animal; Extracellular Space; Female; Inosine; Ischemic Preconditioning, Myocardial; Male; Mice; Mice, Knockout; Myocardial Infarction; Myocardial Ischemia; Sex Factors; Ventricular Function, Left | 2015 |
Adenosine A3 receptor activation is neuroprotective against retinal neurodegeneration.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Animals; Animals, Newborn; Apoptosis; Cell Survival; Disease Models, Animal; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique, Indirect; In Situ Nick-End Labeling; Intravitreal Injections; Male; N-Methylaspartate; Neuroprotection; Optic Nerve Injuries; Organ Culture Techniques; Rats; Rats, Wistar; Receptor, Adenosine A3; Retina; Retinal Degeneration; Retinal Neurons | 2015 |
AMP-activated protein kinase attenuates oxLDL uptake in macrophages through PP2A/NF-κB/LOX-1 pathway.
Topics: Adenosine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Aorta; Apolipoproteins E; Atherosclerosis; Disease Models, Animal; Foam Cells; Lipoproteins, LDL; Macrophages; Mice; Mice, Knockout; NF-kappa B; Okadaic Acid; Protein Phosphatase 2; Ribonucleotides; Scavenger Receptors, Class E | 2016 |
Influence of a modified preservation solution in kidney transplantation: A comparative experimental study in a porcine model.
Topics: Adenosine; Allopurinol; Animals; Biopsy, Needle; Disease Models, Animal; Female; Glucose; Glutathione; Graft Rejection; Graft Survival; Immunohistochemistry; Insulin; Kidney Transplantation; Male; Mannitol; Organ Preservation; Organ Preservation Solutions; Potassium Chloride; Procaine; Raffinose; Random Allocation; Sensitivity and Specificity; Survival Rate; Swine; Treatment Outcome | 2017 |
Progressively heterogeneous mismatch of regional oxygen delivery to consumption during graded coronary stenosis in pig left ventricle.
Topics: Adenosine; Animals; Coronary Circulation; Coronary Stenosis; Disease Models, Animal; Heart Ventricles; Hemodynamics; Magnetic Resonance Spectroscopy; Male; Myocardium; Oxygen; Oxygen Consumption; Severity of Illness Index; Swine; Vasodilator Agents | 2015 |
Fructose 1,6-bisphosphate, a high-energy intermediate of glycolysis, attenuates experimental arthritis by activating anti-inflammatory adenosinergic pathway.
Topics: 5'-Nucleotidase; Adenosine; Adenosine A2 Receptor Antagonists; Animals; Anti-Inflammatory Agents; Antigens, CD; Apyrase; Arthritis, Experimental; Cytokines; Disease Models, Animal; Extracellular Space; Fructosediphosphates; Glycolysis; Male; Metabolic Networks and Pathways; Mice; Receptor, Adenosine A2A; Rheumatic Fever; Signal Transduction | 2015 |
Extracellular adenosine levels are associated with the progression and exacerbation of pulmonary fibrosis.
Topics: Adenosine; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Female; Idiopathic Pulmonary Fibrosis; Interleukin-17; Interleukin-6; Mice; Nucleoside Transport Proteins | 2016 |
Antinociceptive effects of incarvillateine, a monoterpene alkaloid from Incarvillea sinensis, and possible involvement of the adenosine system.
Topics: Adenosine; Alkaloids; Analgesics; Animals; Antineoplastic Agents, Phytogenic; Bignoniaceae; Disease Models, Animal; Edema; Freund's Adjuvant; Hyperalgesia; Interleukin-1beta; Medicine, Chinese Traditional; Mice; Monoterpenes; Motor Activity; Paclitaxel; Pain Measurement; Theobromine; Theophylline; Xanthines | 2015 |
Early impairment of coronary microvascular perfusion capacity in rats on a high fat diet.
Topics: Adenosine; Animals; Coronary Circulation; Coronary Disease; Coronary Vessels; Diet, High-Fat; Disease Models, Animal; Glycocalyx; Hyperemia; Insulin Resistance; Magnetic Resonance Imaging, Cine; Male; Microcirculation; Microvessels; Muscle, Skeletal; Myocardial Perfusion Imaging; Myocardium; Obesity, Abdominal; Phosphorylation; Prediabetic State; Proto-Oncogene Proteins c-akt; Rats, Wistar; Time Factors; Vasodilator Agents; Ventricular Remodeling | 2015 |
Celsior preserves cardiac mechano-energetics better than University of Wisconsin solution by preventing oxidative stress.
Topics: Adenosine; Allopurinol; Animals; Disaccharides; Disease Models, Animal; Dogs; Electrolytes; Glutamates; Glutathione; Heart; Heart Transplantation; Histidine; Insulin; Mannitol; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Organ Preservation Solutions; Oxidative Stress; Raffinose; Tissue Preservation | 2016 |
Inhibition of adenosine metabolism induces changes in post-ictal depression, respiration, and mortality in genetically epilepsy prone rats.
Topics: Adenine; Adenosine; Animals; Blood Gas Analysis; Brugada Syndrome; Disease Models, Animal; Enzyme Inhibitors; Epilepsy; Female; Genetic Predisposition to Disease; Incidence; Male; Oxygen; Rats; Respiration; Respiration Disorders; Seizures; Sex Characteristics; Tubercidin | 2016 |
[Effect of WS070117M1 on chronic obstructive pulmonary disease in mice and the underling mechanisms of anti-inflammation].
Topics: Adenosine; AMP-Activated Protein Kinases; Animals; Bronchoalveolar Lavage Fluid; Cell Line, Tumor; Disease Models, Animal; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Interleukin-8; Leukocyte Count; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Neutrophils; Nicotiana; Pulmonary Disease, Chronic Obstructive; Smoke; Transforming Growth Factor beta1 | 2015 |
Immucillins ImmA and ImmH Are Effective and Non-toxic in the Treatment of Experimental Visceral Leishmaniasis.
Topics: Adenine; Adenosine; Animals; Antibodies, Protozoan; Antiprotozoal Agents; Blood Chemical Analysis; Disease Models, Animal; Drug-Related Side Effects and Adverse Reactions; Female; Gene Expression; Immunophenotyping; Interferon-gamma; Interleukin-10; Leishmania; Leishmaniasis, Visceral; Leukocytes, Mononuclear; Mesocricetus; Mice, Inbred BALB C; Parasite Load; Purine Nucleosides; Pyrimidinones; Pyrrolidines; Spleen; T-Lymphocyte Subsets; Treatment Outcome; Tumor Necrosis Factor-alpha | 2015 |
Limitation of Infarct Size and No-Reflow by Intracoronary Adenosine Depends Critically on Dose and Duration.
Topics: Adenosine; Animals; Coronary Circulation; Coronary Occlusion; Disease Models, Animal; Drug Administration Schedule; Female; Hemodynamics; Infusions, Parenteral; Male; Myocardial Infarction; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardium; No-Reflow Phenomenon; Swine; Time Factors | 2015 |
Dual roles of the adenosine A2a receptor in autoimmune neuroinflammation.
Topics: Adenosine; Animals; Anti-Inflammatory Agents; CD4-Positive T-Lymphocytes; Cell Movement; Cell Proliferation; Cells, Cultured; Cytokines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Macrophages; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Myelin Proteolipid Protein; Myelin-Oligodendrocyte Glycoprotein; Peptide Fragments; Phagocytosis; Phenethylamines; Receptor, Adenosine A2A; Time Factors; Up-Regulation | 2016 |
Extracellular Adenosine Production by ecto-5'-Nucleotidase (CD73) Enhances Radiation-Induced Lung Fibrosis.
Topics: 5'-Nucleotidase; Adenosine; Animals; Apoptosis; Blotting, Western; Cell Proliferation; Disease Models, Animal; GPI-Linked Proteins; Humans; Immunoenzyme Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; Pulmonary Fibrosis; Radiation, Ionizing; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2016 |
Adenosine A1 receptors mediate the intracisternal injection of orexin-induced antinociceptive action against colonic distension in conscious rats.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Analgesics; Animals; Colon; Consciousness; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Male; Orexins; Physical Stimulation; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Reflex; Visceral Pain; Xanthines | 2016 |
Influence of experimental Anaplasma marginale infection and splenectomy on NTPDase and 5'nucleotidase activities in platelets of cattle.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Triphosphatases; Anaplasma marginale; Anaplasmosis; Animals; Blood Platelets; Cattle; Disease Models, Animal; Immune Evasion; Immune Tolerance; Splenectomy | 2016 |
Swertisin, a C-glucosylflavone, ameliorates scopolamine-induced memory impairment in mice with its adenosine A1 receptor antagonistic property.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Apigenin; Avoidance Learning; CHO Cells; Cholinergic Antagonists; CREB-Binding Protein; Cricetulus; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred ICR; Protein Binding; Purinergic P1 Receptor Agonists; Retention, Psychology; Scopolamine | 2016 |
Activation of the adenosine A2A receptor exacerbates experimental autoimmune neuritis in Lewis rats in association with enhanced humoral immunity.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Cattle; CD4-Positive T-Lymphocytes; Cytokines; Dendritic Cells; Disease Models, Animal; Female; Immunity, Humoral; Immunoglobulin G; Leukocytes, Mononuclear; Lymph Nodes; Lymphocytes; Myelin Sheath; Nervous System Diseases; Neuritis, Autoimmune, Experimental; Phenethylamines; Rats; Rats, Inbred Lew; Receptors, Adenosine A2; Sciatic Nerve | 2016 |
Fibrinogen γ-Chain Peptide-Coated Adenosine 5' Diphosphate-Encapsulated Liposomes Rescue Mice From Lethal Blast Lung Injury via Adenosine Signaling.
Topics: Adenosine; Adenosine Diphosphate; Animals; Blast Injuries; Disease Models, Animal; Fibrinogen; Liposomes; Lung Injury; Male; Mice; Mice, Inbred C57BL; Oligopeptides; Platelet Aggregation Inhibitors; Signal Transduction | 2016 |
Purinergic dysregulation in pulmonary hypertension.
Topics: Adenosine; Adenosine Triphosphate; Animals; Antigens, CD; Antihypertensive Agents; Apyrase; Arterial Pressure; Disease Models, Animal; Genetic Predisposition to Disease; Humans; Hydrolysis; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Lung; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Pulmonary Artery; Purinergic P2X Receptor Antagonists; Receptors, Purinergic P2X1; Severity of Illness Index; Signal Transduction; Suramin; Vascular Remodeling; Ventricular Remodeling | 2016 |
Susceptibility to seizure-induced sudden death in DBA/2 mice is altered by adenosine.
Topics: Adenosine; Animals; Caffeine; Death, Sudden; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Female; Male; Mice, Inbred DBA; Purinergic P1 Receptor Antagonists; Pyrazoles; Pyrimidines; Receptors, Purinergic P1; Respiration; Respiration Disorders; Seizures; Tubercidin; Xanthines | 2016 |
Double inhibition of cAMP and mTOR signalling may potentiate the reduction of cell growth in ADPKD cells.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Cell Line; Cell Proliferation; CREB-Binding Protein; Cyclic AMP; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Extracellular Signal-Regulated MAP Kinases; Genetic Predisposition to Disease; Humans; Kidney; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Phosphorylation; Polycystic Kidney, Autosomal Dominant; Protein Kinase Inhibitors; Signal Transduction; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; TRPP Cation Channels | 2017 |
Effect of Cardiovascular Injury on Catabolism of Adenosine and Adenosine 5-'Triphosphate in Systemic Blood in a Freely Moving Rat Model In Vivo.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Cardiovascular Diseases; Disease Models, Animal; Hypoxanthine; Isoproterenol; Rats; Rats, Sprague-Dawley; Uric Acid | 2016 |
Role of A3 adenosine receptor in diabetic neuropathy.
Topics: Action Potentials; Adenosine; Animals; Blood Glucose; Body Weight; Diabetic Neuropathies; Disease Models, Animal; Eating; Hyperalgesia; Male; Mice; Muscle, Skeletal; Neural Conduction; NF-kappa B; Pain Threshold; Receptor, Adenosine A3; Sciatic Nerve; Spinal Cord; Streptozocin | 2016 |
Sustained Elevated Adenosine via ADORA2B Promotes Chronic Pain through Neuro-immune Interaction.
Topics: Adenosine; Adenosine Deaminase; Anemia, Sickle Cell; Animals; Behavior, Animal; Chronic Pain; Disease Models, Animal; Ganglia, Spinal; Gene Expression Regulation; Inflammation; Interleukin-6; Mice, Knockout; Myeloid Cells; Nervous System; Nociceptors; Receptor, Adenosine A2B; Receptors, Interleukin-6; Reflex; Sensory Receptor Cells; Signal Transduction; Solubility; STAT3 Transcription Factor; TRPV Cation Channels; Up-Regulation | 2016 |
Role of the CD39/CD73 Purinergic Pathway in Modulating Arterial Thrombosis in Mice.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Antigens, CD; Apyrase; Arterial Occlusive Diseases; Blood Coagulation; Bone Marrow Transplantation; Chlorides; Disease Models, Animal; Endothelial Cells; Ferric Compounds; Genetic Predisposition to Disease; HEK293 Cells; Humans; Hydrolysis; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Monocytes; Phenotype; Platelet Activation; Thrombosis; Time Factors; Transfection | 2016 |
Dermatophagoides pteronyssinus group 2 allergen bound to 8-OH modified adenine reduces the Th2-mediated airway inflammation without inducing a Th17 response and autoimmunity.
Topics: Adenosine; Animals; Antigens, Dermatophagoides; Arthropod Proteins; Dermatophagoides pteronyssinus; Desensitization, Immunologic; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Immunoconjugates; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Knockout; Polymerase Chain Reaction; Respiratory Hypersensitivity; Th17 Cells; Th2 Cells | 2016 |
COA-Cl, a Novel Synthesized Nucleoside Analog, Exerts Neuroprotective Effects in the Acute Phase of Intracerebral Hemorrhage.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adenosine; Animals; Antioxidants; Apoptosis; Behavior, Animal; Biomarkers; Body Water; Brain; Brain Edema; Cerebral Hemorrhage; Deoxyguanosine; Disease Models, Animal; Injections, Intraventricular; Male; Motor Activity; Neuroprotective Agents; Oxidative Stress; Rats, Sprague-Dawley; Time Factors | 2016 |
Renoprotective Effects of a Highly Selective A3 Adenosine Receptor Antagonist in a Mouse Model of Adriamycin-induced Nephropathy.
Topics: Actins; Adenosine; Adenosine A3 Receptor Antagonists; Albuminuria; Animals; Body Weight; Creatinine; Dinoprost; Disease Models, Animal; Doxorubicin; Immunohistochemistry; Kidney; Kidney Diseases; Lipid Peroxidation; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; NF-kappa B; Oxidative Stress; Plasminogen Activator Inhibitor 1; Proteinuria; Transforming Growth Factor beta1 | 2016 |
Equilibrative nucleoside transporter ENT1 as a biomarker of Huntington disease.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Biomarkers; Corpus Striatum; Disease Models, Animal; Gene Expression Regulation; Humans; Huntingtin Protein; Huntington Disease; Locomotion; Nucleoside Transport Proteins; Prefrontal Cortex; Psychomotor Disorders; Purines; Rats; Rats, Transgenic; Receptor, Adenosine A2A; Triazines; Triazoles; Trinucleotide Repeat Expansion; Tritium | 2016 |
Small-Volume Adenosine, Lidocaine, and Mg2+ 4-Hour Infusion Leads to 88% Survival after 6 Days of Experimental Sepsis in the Rat without Antibiotics.
Topics: Acidosis; Adenosine; Animals; Anti-Bacterial Agents; C-Reactive Protein; Cytokines; Disease Models, Animal; Drug Therapy, Combination; Edema; Hyperkalemia; Infusions, Intravenous; Interleukin-1beta; Interleukin-6; Lidocaine; Magnesium Sulfate; Male; Rats; Sepsis | 2016 |
Activating mu-opioid receptors in the spinal cord mediates the cardioprotective effect of remote preconditioning of trauma.
Topics: Adenosine; Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Intercellular Adhesion Molecule-1; Ischemic Preconditioning, Myocardial; Male; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Cord; Troponin I | 2017 |
Ticagrelor promotes atherosclerotic plaque stability in a mouse model of advanced atherosclerosis.
Topics: Adenosine; Administration, Oral; Animals; Apolipoproteins E; Apoptosis; Atherosclerosis; Disease Models, Animal; Dose-Response Relationship, Drug; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Plaque, Atherosclerotic; Structure-Activity Relationship; Ticagrelor | 2016 |
Protein phosphatase 2A activation attenuates inflammation in murine models of acute lung injury.
Topics: Acute Lung Injury; Adenosine; Animals; Cell Line; Chemokines; Disease Models, Animal; Endotoxins; Enzyme Activation; Epithelial Cells; Inflammation; JNK Mitogen-Activated Protein Kinases; Macrophages, Alveolar; Mice, Inbred C57BL; Phosphorylation; Protein Phosphatase 2; Pseudomonas aeruginosa; Respiratory Distress Syndrome | 2016 |
Breathing Maneuvers as a Vasoactive Stimulus for Detecting Inducible Myocardial Ischemia - An Experimental Cardiovascular Magnetic Resonance Study.
Topics: Adenosine; Animals; Blood Gas Analysis; Breathing Exercises; Coronary Angiography; Coronary Stenosis; Coronary Vessels; Disease Models, Animal; Fluoroscopy; Hyperventilation; Magnetic Resonance Imaging, Cine; Myocardium; Oxygen; Oxygen Consumption; Swine; Vasodilator Agents | 2016 |
METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N
Topics: Adenosine; Animals; Carcinoma, Hepatocellular; Disease Models, Animal; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Male; Methyltransferases; Mice; Mice, Inbred BALB C; MicroRNAs; Neoplasm Metastasis; RNA Interference; Sensitivity and Specificity; Signal Transduction; Survival Rate; Tumor Cells, Cultured | 2017 |
Efficacy of the broad-spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse model.
Topics: Adenine; Adenosine; Animals; Antiviral Agents; Brain; Cell Line; Disease Models, Animal; Humans; Male; Mice; Purine Nucleosides; Pyrrolidines; RNA, Viral; Testis; Viral Load; Viremia; Virus Replication; Zika Virus; Zika Virus Infection | 2017 |
Changes in cardiac nucleotide metabolism in Huntington's disease.
Topics: Adenosine; Adenosine Deaminase; AMP Deaminase; Animals; Disease Models, Animal; Humans; Huntington Disease; Inosine; Mice; Myocardium; Purine-Nucleoside Phosphorylase; Pyrophosphatases | 2016 |
Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression.
Topics: Adenosine; Animals; Blood Coagulation; Blood Platelets; Carotid Artery Injuries; Cells, Cultured; Clopidogrel; Disease Models, Animal; Down-Regulation; Endothelial Cells; Equilibrative Nucleoside Transporter 1; Fibrinolytic Agents; Humans; Male; Mice, Inbred C57BL; Platelet Aggregation Inhibitors; Proteasome Endopeptidase Complex; Proteolysis; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thromboplastin; Thrombosis; Ticagrelor; Ticlopidine; Time Factors; Tumor Necrosis Factor-alpha | 2017 |
Targeting ENT1 and adenosine tone for the treatment of Huntington's disease.
Topics: Adenine; Adenosine; Animals; Corpus Striatum; Disease Models, Animal; Equilibrative Nucleoside Transporter 1; Equilibrative-Nucleoside Transporter 2; Humans; Huntingtin Protein; Huntington Disease; Indoles; Mice; Mice, Transgenic; Neostriatum; Trinucleotide Repeat Expansion | 2017 |
Regulation of Expression of Hyperalgesic Priming by Estrogen Receptor α in the Rat.
Topics: 5'-Nucleotidase; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine Monophosphate; Animals; Chronic Pain; Dinoprostone; Disease Models, Animal; DNA, Antisense; Estrogen Receptor alpha; Female; Gene Expression Regulation; Hyperalgesia; Male; Pain Threshold; Rats; Rats, Sprague-Dawley; Ryanodine; Sex Factors; Time Factors; Xanthines | 2017 |
A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A.
Topics: Adenosine; Animals; Biomarkers; Carbon Tetrachloride; Collagen Type I; Disease Models, Animal; Disease Progression; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation; Hepatic Stellate Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Liver Cirrhosis; Male; Mice; Myofibroblasts | 2017 |
Purinergic enzymatic activities in lymphocytes and cardiomyocytes of mice acutely infected by Trypanosoma cruzi modulating the inflammatory responses.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Antigens, CD; Apyrase; Chagas Disease; Disease Models, Animal; Female; Heart; Hematologic Tests; Hydrolysis; Lymphocytes; Mice; Myocardium; Myocytes, Cardiac; Parasitemia; Purines; Trypanosoma cruzi | 2017 |
Electroacupuncture Attenuates CFA-induced Inflammatory Pain by suppressing Nav1.8 through S100B, TRPV1, Opioid, and Adenosine Pathways in Mice.
Topics: Acupuncture Analgesia; Adenosine; Analgesics, Opioid; Animals; Behavior, Animal; Biomarkers; Chromones; Disease Models, Animal; Electroacupuncture; Freund's Adjuvant; Gene Deletion; Gene Expression; Gene Knockout Techniques; Glial Fibrillary Acidic Protein; Male; Mice; Morpholines; NAV1.8 Voltage-Gated Sodium Channel; Neurons; Pain; Pain Management; Proto-Oncogene Proteins c-akt; S100 Calcium Binding Protein beta Subunit; Signal Transduction; Spinal Cord Dorsal Horn; TOR Serine-Threonine Kinases; TRPV Cation Channels; Xanthines | 2017 |
Cancer chemoprevention by an adenosine derivative in a model of cirrhosis-hepatocellular carcinoma induced by diethylnitrosamine in rats.
Topics: Adenosine; Animals; Anticarcinogenic Agents; Diethylnitrosamine; Disease Models, Animal; Liver Cirrhosis; Liver Neoplasms, Experimental; Male; Rats; Rats, Wistar | 2017 |
Design, synthesis, and evaluation of fused heterocyclic analogs of SCH 58261 as adenosine A2A receptor antagonists.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Administration, Oral; Animals; Area Under Curve; Chemistry, Pharmaceutical; Disease Models, Animal; Drug Design; Hydrogen-Ion Concentration; Models, Chemical; Parkinson Disease; Pyrimidines; Rats; Solubility; Triazoles; Water | 2008 |
The role of piriform cortex adenosine A1 receptors on hippocampal kindling.
Topics: Adenosine; Analysis of Variance; Animals; Disease Models, Animal; Drug Interactions; Electric Stimulation; Electroencephalography; Entorhinal Cortex; Hippocampus; Kindling, Neurologic; Male; Microinjections; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Seizures; Time Factors; Xanthines | 2008 |
Adenosine A2A receptor antagonism increases nNOS-immunoreactive neurons in the striatum of Huntington transgenic mice.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Corpus Striatum; Cytoprotection; Disease Models, Animal; Enzyme Activation; Huntington Disease; Interneurons; Male; Mice; Mice, Transgenic; Neuroprotective Agents; Nitrergic Neurons; Nitric Oxide; Nitric Oxide Synthase Type I; Pyrimidines; Receptor, Adenosine A2A; Triazoles; Up-Regulation | 2008 |
The A3 adenosine receptor agonist CF502 inhibits the PI3K, PKB/Akt and NF-kappaB signaling pathway in synoviocytes from rheumatoid arthritis patients and in adjuvant-induced arthritis rats.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Arthritis; Arthritis, Rheumatoid; Disease Models, Animal; Humans; Inflammation; NF-kappa B; Phosphatidylinositol 3-Kinases; Protein Kinases; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Synovial Membrane | 2008 |
Allergen-induced airway hyperresponsiveness is absent in ecto-5'-nucleotidase (CD73)-deficient mice.
Topics: 5'-Nucleotidase; Adenine Nucleotides; Adenosine; Allergens; Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Chlorides; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mucociliary Clearance; Ovalbumin; Trachea | 2008 |
Effects of binge alcohol exposure in the second trimester on intracerebral arteriolar function in third trimester fetal sheep.
Topics: Adenosine; Animals; Antihypertensive Agents; Arterioles; Cerebrovascular Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Embryo, Mammalian; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Hypoxia; Phenethylamines; Pregnancy; Prenatal Exposure Delayed Effects; Sheep; Vasodilation | 2008 |
Intravenous adenosine reduces myocardial no-reflow by decreasing endothelin-1 via activation of the ATP-sensitive K+ channel.
Topics: Adenosine; Animals; Coronary Circulation; Disease Models, Animal; Echocardiography; Endothelin-1; Injections, Intravenous; KATP Channels; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Radioimmunoassay; Random Allocation; Swine; Swine, Miniature; Treatment Outcome; Vasodilator Agents | 2008 |
Adenosine A2A receptor activation reduces infarct size in the isolated, perfused mouse heart by inhibiting resident cardiac mast cell degranulation.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Bone Marrow Transplantation; Cardiovascular Agents; Cell Degranulation; Cells, Cultured; Cyclohexanecarboxylic Acids; Disease Models, Animal; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Mutant Strains; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Perfusion; Phenethylamines; Purines; Receptor, Adenosine A2A; Time Factors; Tryptases; Whole-Body Irradiation | 2008 |
Extracellular adenosine production by ecto-5'-nucleotidase protects during murine hepatic ischemic preconditioning.
Topics: 5'-Nucleotidase; Adenosine; Animals; Blotting, Western; Disease Models, Animal; Extracellular Fluid; Ischemic Preconditioning; Liver; Mice; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA; Transcription, Genetic | 2008 |
Ischemia-driven expression of CD73 confers tissue protection during liver ischemia/reperfusion.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Diphosphate; Animals; Disease Models, Animal; Extracellular Fluid; Liver; Mice; Mice, Knockout; Reperfusion Injury | 2008 |
Inhibition of methylation and changes in gene expression in relation to neural tube defects.
Topics: Adenosine; Animals; Chick Embryo; Disease Models, Animal; DNA Methylation; Gene Expression; Neural Tube Defects | 2008 |
Role of NOX2 in the regulation of afferent arteriole responsiveness.
Topics: Acetophenones; Adenosine; Angiotensin II; Animals; Arterioles; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypertension; Infusion Pumps, Implantable; Infusions, Subcutaneous; Kidney Cortex; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidase 2; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Renal Circulation; Superoxides; Vasoconstriction; Vasoconstrictor Agents | 2009 |
Effect of blocking platelet activation with AZD6140 on development of abdominal aortic aneurysm in a rat aneurysmal model.
Topics: Adenosine; Adenosine Diphosphate; Animals; Aorta; Aortic Aneurysm, Abdominal; Blood Platelets; Disease Models, Animal; Disease Progression; Elastic Tissue; Guinea Pigs; Inflammation; Male; Matrix Metalloproteinase 9; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Rats; Rats, Inbred Lew; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thrombosis; Ticagrelor; Time Factors; Transplantation, Heterologous | 2009 |
Involvement of A2A receptors in anxiolytic, locomotor and motivational properties of ethanol in mice.
Topics: Adenosine; Alcohol-Induced Disorders, Nervous System; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Brain; Central Nervous System Depressants; Conditioning, Psychological; Disease Models, Animal; Drug Resistance; Ethanol; Genotype; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motivation; Motor Activity; Receptor, Adenosine A2A; Species Specificity | 2008 |
Hypoxia-inducible factor-dependent repression of equilibrative nucleoside transporter 2 attenuates mucosal inflammation during intestinal hypoxia.
Topics: Adenosine; Animals; Caco-2 Cells; Cell Line, Tumor; Cells, Cultured; Colon; Disease Models, Animal; Equilibrative-Nucleoside Transporter 2; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Intestinal Mucosa; Mice; Mice, Inbred C57BL | 2009 |
Effects of progesterone on total brain tissue adenosine deaminase activity in experimental epilepsy.
Topics: Adenosine; Adenosine Deaminase; Animals; Brain; Convulsants; Disease Models, Animal; Epilepsy; Female; Male; Mice; Pentylenetetrazole; Polyunsaturated Alkamides; Progesterone; Propionates; Receptor, Adenosine A1; Receptors, GABA-A | 2009 |
Adenosine modulates alpha2-adrenergic receptors within specific subnuclei of the nucleus tractus solitarius in normotensive and spontaneously hypertensive rats.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension; Intranuclear Space; Male; Protein Binding; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Adenosine A1; Receptors, Adrenergic, alpha-2; Solitary Nucleus; Xanthines | 2008 |
Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Astrocytes; Brain; Cell Communication; Cognition Disorders; Disease Models, Animal; Electroencephalography; Green Fluorescent Proteins; Homeostasis; Injections, Intraventricular; Mice; Mice, Transgenic; Neurons; Receptor, Adenosine A1; Sleep; Sleep Deprivation; SNARE Proteins; Transgenes | 2009 |
Protein phosphatase 2A contributes to the cardiac dysfunction induced by endotoxemia.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Endotoxemia; Isoquinolines; Lipopolysaccharides; Methylation; Mice; Mice, Inbred C57BL; Myocardial Contraction; Myocytes, Cardiac; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase Inhibitors; Protein Methyltransferases; Protein Phosphatase 2; Protein Phosphatase 2C; Protein Processing, Post-Translational; Receptor, Adenosine A1; Sulfonamides; Time Factors; Troponin I | 2009 |
Human mesenchymal stem cell grafts engineered to release adenosine reduce chronic seizures in a mouse model of CA3-selective epileptogenesis.
Topics: Adenosine; Adenosine Kinase; Analysis of Variance; Animals; Disease Models, Animal; Electroencephalography; Green Fluorescent Proteins; Hippocampus; Humans; Indoles; Kainic Acid; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; MicroRNAs; Seizures; Tissue Engineering; Transfection | 2009 |
Blocking adenosine A2A receptor reduces peritoneal fibrosis in two independent experimental models.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Cells, Cultured; Central Nervous System Stimulants; Chlorhexidine; Collagen; Disease Models, Animal; Fibroblasts; Fibrosis; Mice; Mice, Knockout; Peritoneal Cavity; Phenethylamines; Vasodilator Agents | 2009 |
Adenosine signaling contributes to ethanol-induced fatty liver in mice.
Topics: 5'-Nucleotidase; Adenosine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Disease Models, Animal; Fatty Liver, Alcoholic; Mice; Mice, Inbred Strains; Mice, Knockout; Receptor, Adenosine A1; Receptor, Adenosine A2B; Receptors, Purinergic P1; Signal Transduction; Triglycerides | 2009 |
Nonresolving inflammation in gp91phox-/- mice, a model of human chronic granulomatous disease, has lower adenosine and cyclic adenosine 5'-monophosphate.
Topics: Acute Disease; Adenosine; Animals; Cells, Cultured; Cyclic AMP; Disease Models, Animal; Granulomatous Disease, Chronic; Humans; Inflammation; Inflammation Mediators; Leukopenia; Membrane Glycoproteins; Mice; Mice, Knockout; NADPH Oxidase 2; NADPH Oxidases; Peritonitis | 2009 |
Pentamidine movement across the murine blood-brain and blood-cerebrospinal fluid barriers: effect of trypanosome infection, combination therapy, P-glycoprotein, and multidrug resistance-associated protein.
Topics: Adenine; Adenosine; Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Blood-Brain Barrier; Brain; Cerebrospinal Fluid; Disease Models, Animal; Drug Interactions; Eflornithine; Indomethacin; Male; Melarsoprol; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Mice, Knockout; Multidrug Resistance-Associated Proteins; Nifurtimox; Pentamidine; Perfusion; Suramin; Trypanosoma brucei brucei; Trypanosomiasis, African | 2009 |
Management of erectile function by penile purinergic p2 receptors in the diabetic rat.
Topics: Adenosine; Adenosine Triphosphate; Animals; Diabetes Mellitus; Disease Models, Animal; Immunohistochemistry; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Penile Erection; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; Reference Values; Sensitivity and Specificity; Streptozocin; Thionucleosides; Uridine Triphosphate | 2009 |
Integration of skeletal muscle resistance arteriolar reactivity for perfusion responses in the metabolic syndrome.
Topics: Adenosine; Adrenergic alpha-Antagonists; Adrenergic Fibers; Animals; Antioxidants; Arachidonic Acid; Arterioles; Disease Models, Animal; Endothelium, Vascular; Hindlimb; Hyperemia; Hypoxia; Male; Metabolic Syndrome; Microcirculation; Muscle, Skeletal; Muscle, Smooth, Vascular; Obesity; Oxidative Stress; Rats; Rats, Zucker; Regional Blood Flow; Vascular Resistance; Vasoconstriction; Vasodilation; Vasodilator Agents | 2009 |
A2A adenosine receptor deficiency leads to impaired tracheal relaxation via NADPH oxidase pathway in allergic mice.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Asthma; Disease Models, Animal; Female; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Relaxation; Muscle, Smooth; NADPH Oxidases; Phenethylamines; Reactive Oxygen Species; Receptor, Adenosine A2A; Signal Transduction; Trachea | 2009 |
Spinal NMDA receptor activation is necessary for de novo, but not the maintenance of, A2a receptor-mediated phrenic motor facilitation.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Antihypertensive Agents; Disease Models, Animal; Dizocilpine Maleate; Drug Interactions; Male; Motor Neurons; Neuroprotective Agents; Phenethylamines; Phrenic Nerve; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptor, trkB; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Spinal Cord Injuries | 2009 |
Myocardial microvascular function during acute coronary artery stenosis: effect of hypertension and hypercholesterolaemia.
Topics: Adenosine; Animals; Capillary Permeability; Collateral Circulation; Coronary Angiography; Coronary Circulation; Coronary Stenosis; Coronary Vessels; Disease Models, Animal; Female; Hypercholesterolemia; Hypertension, Renovascular; Infusions, Intravenous; Microcirculation; Neovascularization, Physiologic; Sus scrofa; Tomography, X-Ray Computed; X-Ray Microtomography | 2009 |
The A2A adenosine receptor rescues the urea cycle deficiency of Huntington's disease by enhancing the activity of the ubiquitin-proteasome system.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Cell Line; Disease Models, Animal; Female; Humans; Huntington Disease; Liver; Male; Mice; Phenethylamines; Proteasome Endopeptidase Complex; Receptor, Adenosine A2A; Serotonin Plasma Membrane Transport Proteins; Ubiquitin; Urea | 2009 |
Antiepileptic effects of silk-polymer based adenosine release in kindled rats.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Anticonvulsants; Disease Models, Animal; Drug Delivery Systems; Drug Implants; Electric Stimulation; Epilepsy; Hippocampus; Kindling, Neurologic; Male; Polymers; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Seizures; Silk; Treatment Outcome | 2009 |
Protective effects of adenosine A2A receptor agonist in ventilator-induced lung injury in rats.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Blood Gas Analysis; Blood Pressure; Cytokines; Disease Models, Animal; Male; Phenethylamines; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Respiratory Mechanics; Shock, Hemorrhagic; Ventilator-Induced Lung Injury | 2009 |
Adenosine A2A receptor deficient mice are partially resistant to limbic seizures.
Topics: Adenosine; Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Epilepsy; Male; Mice; Mice, Knockout; Pentylenetetrazole; Pilocarpine; Receptor, Adenosine A2A; Seizures | 2009 |
Vascular stasis, intestinal hemorrhage, and heightened vascular permeability complicate acute portal hypertension in cd39-null mice.
Topics: Acute Disease; Adenosine; Adenosine Triphosphate; Animals; Antigens, CD; Apyrase; Capillary Permeability; Constriction, Pathologic; Disease Models, Animal; Gastrointestinal Hemorrhage; Hypertension, Portal; Ligation; Mice; Mice, Inbred C57BL; Mice, Knockout; Microcirculation; Nitric Oxide; Portal Pressure; Portal Vein; Splanchnic Circulation; Time Factors | 2009 |
Time-course changes in ectonucleotidase activities during experimental autoimmune encephalomyelitis.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Apyrase; Cell Membrane; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Multiple Sclerosis; Rats; Rats, Inbred Strains; Spinal Cord; Time Factors | 2009 |
Adenosine regulation of microtubule dynamics in cardiac hypertrophy.
Topics: 2-Chloroadenosine; 5'-Nucleotidase; Adenosine; Animals; Cardiomegaly; Cells, Cultured; Colchicine; Disease Models, Animal; Mice; Mice, Inbred BALB C; Mice, Knockout; Microtubules; Myocardial Contraction; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Tubulin; Tubulin Modulators | 2009 |
Attenuation of chronic pulmonary inflammation in A2B adenosine receptor knockout mice.
Topics: Adenosine; Allergens; Animals; Bronchi; Bronchoalveolar Lavage Fluid; Chronic Disease; Disease Models, Animal; Eosinophils; Gene Deletion; Gene Expression Regulation; Hypertrophy; Interleukin-4; Metaplasia; Mice; Mice, Inbred C57BL; Mice, Knockout; Mucus; Myocytes, Smooth Muscle; Pneumonia; Receptor, Adenosine A2B; RNA, Messenger; Transforming Growth Factor beta | 2010 |
Theophylline attenuates hippocampal blood flow responses induced by tooth pulp stimulation in rats.
Topics: Adenosine; Afferent Pathways; Animals; Cerebral Arteries; Cerebrovascular Circulation; Dental Pulp Cavity; Disease Models, Animal; Electric Stimulation; Hippocampus; Injections, Intraperitoneal; Laser-Doppler Flowmetry; Male; Nociceptors; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Theophylline; Toothache; Vasodilator Agents | 2009 |
Differential effects of adenosine antagonists in two models of parkinsonian tremor.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Cholinergic Agonists; Disease Models, Animal; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Drug Synergism; Jaw; Male; Parkinsonian Disorders; Pimozide; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Sprague-Dawley; Tacrine; Theophylline; Tremor; Triazoles | 2009 |
Fructose-1,6-bisphosphate reduces inflammatory pain-like behaviour in mice: role of adenosine acting on A1 receptors.
Topics: Adenosine; Analgesics; Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Fructosediphosphates; Hyperalgesia; Inflammation; Male; Mice; Pain Measurement; Receptor, Adenosine A1 | 2009 |
A novel mouse model for sudden unexpected death in epilepsy (SUDEP): role of impaired adenosine clearance.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Caffeine; Cause of Death; Death, Sudden; Disease Models, Animal; Enzyme Inhibitors; Epilepsy; Kainic Acid; Mice; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Risk Factors; Seizures; Survival Analysis; Tubercidin | 2010 |
Comparison of ticagrelor and thienopyridine P2Y(12) binding characteristics and antithrombotic and bleeding effects in rat and dog models of thrombosis/hemostasis.
Topics: Adenosine; Animals; CHO Cells; Clopidogrel; Cricetinae; Cricetulus; Disease Models, Animal; Dogs; Hemostasis; Humans; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Pyridines; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thiophenes; Thrombosis; Ticagrelor; Ticlopidine; Transfection | 2009 |
Adenosine A 2A receptor deficiency reduces striatal glutamate outflow and attenuates brain injury induced by transient focal cerebral ischemia in mice.
Topics: Adenosine; Animals; Brain Chemistry; Brain Infarction; Brain Ischemia; Corpus Striatum; Disease Models, Animal; Down-Regulation; Extracellular Fluid; Gene Expression Regulation; Genetic Predisposition to Disease; Glutamic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Receptor, Adenosine A2A; Up-Regulation | 2009 |
Adenosine and osteopontin contribute to the development of chronic obstructive pulmonary disease.
Topics: Adenosine; Adenosine Deaminase; Animals; Disease Models, Animal; Emphysema; Female; Gene Expression; Humans; In Vitro Techniques; Macrophages, Alveolar; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Osteopontin; Pulmonary Disease, Chronic Obstructive; Pulmonary Fibrosis; Receptor, Adenosine A2B; RNA, Messenger | 2010 |
Altered distribution and function of A2A adenosine receptors in the brain of WAG/Rij rats with genetic absence epilepsy, before and after appearance of the disease.
Topics: Adenosine; Age Factors; Analysis of Variance; Animals; Blotting, Western; Disease Models, Animal; Disease Progression; Electroencephalography; Epilepsy, Absence; Glutamic Acid; Immunohistochemistry; Male; MAP Kinase Signaling System; Microinjections; Phenethylamines; Pyrimidines; Rats; Receptor, Adenosine A2A; Somatosensory Cortex; Thalamus; Triazoles | 2009 |
Accuracy of cardiac magnetic resonance of absolute myocardial blood flow with a high-field system: comparison with conventional field strength.
Topics: Adenosine; Animals; Contrast Media; Coronary Circulation; Disease Models, Animal; Gadolinium DTPA; Hyperemia; Magnetic Resonance Imaging; Microspheres; Myocardial Ischemia; Myocardial Perfusion Imaging; Predictive Value of Tests; Reproducibility of Results; Swine; Time Factors | 2009 |
Unmasking the tonic-aversive state in neuropathic pain.
Topics: Adenosine; Analgesics; Analysis of Variance; Animals; Calcium Channel Blockers; Clonidine; Conditioning, Classical; Conditioning, Psychological; Disease Models, Animal; Drug Administration Schedule; Hyperalgesia; Injections, Spinal; Male; Neuralgia; omega-Conotoxins; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Reaction Time; Reward; Time Factors | 2009 |
Induction of an antiinflammatory effect and prevention of cartilage damage in rat knee osteoarthritis by CF101 treatment.
Topics: Adenosine; Adenosine A3 Receptor Antagonists; Animals; Anti-Inflammatory Agents; Apoptosis; Cartilage, Articular; Disease Models, Animal; Inflammation; Iodoacetates; Male; NF-kappa B; Osteoarthritis; Rats; Rats, Wistar; Signal Transduction | 2009 |
Effects of adenosine and a selective A2A adenosine receptor agonist on hemodynamic and thallium-201 and technetium-99m-sestaMIBI biodistribution and kinetics.
Topics: Acute Disease; Adenosine; Adenosine A2 Receptor Agonists; Animals; Blood Flow Velocity; Chronic Disease; Coronary Circulation; Coronary Stenosis; Disease Models, Animal; Dogs; Hyperemia; Infusions, Intravenous; Injections, Intravenous; Metabolic Clearance Rate; Myocardial Perfusion Imaging; Myocardium; Predictive Value of Tests; Purines; Pyrazoles; Radiopharmaceuticals; Receptor, Adenosine A2A; Technetium Tc 99m Sestamibi; Thallium Radioisotopes; Tissue Distribution; Tomography, Emission-Computed, Single-Photon; Vasodilator Agents | 2009 |
Adenosine A1 receptor blockage mediates theophylline-associated seizures.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine Kinase; Animals; Behavior, Animal; Body Temperature; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Enzyme Inhibitors; Hyperthermia, Induced; Injections, Intraperitoneal; Male; Rats; Rats, Inbred Lew; Seizures; Theophylline; Tubercidin | 2010 |
Regulation of adenosine system at the onset of peritonitis.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Deaminase; Adenosine Kinase; Animals; Antigens, CD; Apyrase; Disease Models, Animal; Escherichia coli; Injections, Intraperitoneal; Interleukin-6; Mice; Mice, Inbred Strains; Peritonitis; Receptors, Interleukin-6; Receptors, Purinergic P1; Tumor Necrosis Factor-alpha | 2010 |
Adenosine restores the hepatic artery buffer response and improves survival in a porcine model of small-for-size syndrome.
Topics: Adenosine; Animals; Blood Pressure; Buffers; Disease Models, Animal; Female; Graft Survival; Hepatic Artery; Ischemia; Kaplan-Meier Estimate; Liver Circulation; Liver Transplantation; Organ Size; Postoperative Complications; Swine; Vasoconstriction | 2009 |
Compensatory upregulation of the adenosine system following phenylephrine-induced hypertrophy in cultured rat ventricular myocytes.
Topics: Adenosine; Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Heart Ventricles; Myocytes, Cardiac; Nucleoside Transport Proteins; Phenylephrine; Prazosin; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; RNA, Messenger; Up-Regulation | 2010 |
Post exposure administration of A(1) adenosine receptor agonists attenuates noise-induced hearing loss.
Topics: Acoustic Stimulation; Adenosine; Adenosine A1 Receptor Agonists; Animals; Auditory Threshold; Cochlea; Cochlear Microphonic Potentials; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Hearing Loss, Noise-Induced; Male; Oxidative Stress; Phenethylamines; Rats; Rats, Wistar; Receptor, Adenosine A1; Time Factors; Tyrosine | 2010 |
Adenosine A1 receptor agonists reduce hyperalgesia after spinal cord injury in rats.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Analgesics; Animals; Disease Models, Animal; Female; Hyperalgesia; Phenethylamines; Rats; Rats, Wistar; Receptor, Adenosine A1; Spinal Cord; Spinal Cord Compression; Treatment Outcome; Xanthines | 2010 |
Decreased purinergic inhibition of synaptic activity in a mouse model of Niemann-Pick disease type C.
Topics: Adenosine; Animals; CA1 Region, Hippocampal; Disease Models, Animal; Electrophysiological Phenomena; Excitatory Postsynaptic Potentials; Hippocampus; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Long-Term Potentiation; Mice; Mice, Inbred BALB C; Mice, Mutant Strains; Mutant Proteins; Niemann-Pick C1 Protein; Niemann-Pick Disease, Type C; Proteins; Receptor, Adenosine A1; Synapses; Synaptic Transmission | 2011 |
A comparison of hypothermic machine perfusion versus static cold storage in an experimental model of renal ischemia reperfusion injury.
Topics: Acid-Base Equilibrium; Adenosine; Allopurinol; Animals; Aspartate Aminotransferases; Biomarkers; Citrates; Cold Ischemia; Creatinine; Disease Models, Animal; Equipment Design; Glucose; Glutathione; Hypothermia, Induced; Insulin; Kidney; Kidney Transplantation; L-Lactate Dehydrogenase; Lipid Peroxidation; Mannitol; Organ Preservation Solutions; Oxidative Stress; Perfusion; Peroxidase; Potassium Chloride; Procaine; Raffinose; Reperfusion Injury; Swine; Time Factors | 2010 |
Adenosine A1 receptor activation as a brake on the microglial response after experimental traumatic brain injury in mice.
Topics: Adenosine; Animals; Brain Injuries; Cell Line, Transformed; Cerebral Cortex; Disease Models, Animal; Female; Gliosis; Growth Inhibitors; Hippocampus; Male; Mice; Mice, Knockout; Microglia; Nerve Degeneration; Receptor, Adenosine A1; Thalamus | 2010 |
Cardioprotection with adenosine-regulating agent, GP531: effects on no-reflow, infarct size, and blood flow following ischemia/ reperfusion in the rabbit.
Topics: Adenosine; Aminoimidazole Carboxamide; Analysis of Variance; Animals; Deoxyribonucleosides; Disease Models, Animal; Hemodynamics; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Rabbits; Random Allocation | 2010 |
Influence of CGS 21680, a selective adenosine A(2A) receptor agonist, on NMDA receptor function and expression in the brain of Huntington's disease mice.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Blotting, Western; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Electrophysiology; Female; Huntington Disease; Male; Mice; Neurons; Phenethylamines; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Statistics, Nonparametric | 2010 |
Changes induced by formalin pain in central alpha1-adrenoceptor density are modulated by adenosine receptor agonists.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Analgesics; Animals; Autoradiography; Central Nervous System; Disease Models, Animal; Inflammation; Male; Mice; Nociceptors; Pain; Pain Measurement; Phenethylamines; Prazosin; Receptor, Adenosine A2A; Receptors, Adrenergic, alpha-1 | 2010 |
Conversion of Th17-type into Th2-type inflammation by acetyl salicylic acid via the adenosine and uric acid pathway in the lung.
Topics: Adenosine; Allergens; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Disease Models, Animal; Humans; Inflammation; Lipopolysaccharides; Lung; Mice; Mice, Inbred C57BL; Th17 Cells; Th2 Cells; Uric Acid | 2010 |
Oxygenation-sensitive CMR for assessing vasodilator-induced changes of myocardial oxygenation.
Topics: Acetylcholine; Adenosine; Animals; Blood Flow Velocity; Contrast Media; Coronary Circulation; Disease Models, Animal; Dogs; Gadolinium DTPA; Hyperemia; Magnetic Resonance Imaging, Cine; Microcirculation; Myocardium; Oxygen; Oxygen Consumption; Time Factors; Vasodilator Agents | 2010 |
Activation of A1, A2A, or A3 adenosine receptors attenuates lung ischemia-reperfusion injury.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Animals; Blood Pressure; Disease Models, Animal; In Vitro Techniques; Lung; Lung Compliance; Lung Diseases; Perfusion; Peroxidase; Piperidines; Protective Agents; Pulmonary Artery; Pulmonary Edema; Rabbits; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Adenosine A3; Reperfusion Injury; Tumor Necrosis Factor-alpha | 2010 |
Involvement of A1 adenosine receptors in altered vascular responses and inflammation in an allergic mouse model of asthma.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Administration, Inhalation; Aerosols; Ambrosia; Animals; Antigens, Plant; Aorta; Asthma; Blotting, Western; Bronchial Hyperreactivity; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationship, Drug; Inflammation; Inflammation Mediators; Intercellular Adhesion Molecule-1; Interleukin-5; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Plethysmography, Whole Body; Polymerase Chain Reaction; Receptor, Adenosine A1; RNA, Messenger; Vasodilation | 2010 |
A distinct nitric oxide and adenosine A1 receptor dependent hepatic artery vasodilatatory response in the CCl-cirrhotic liver.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Blotting, Western; Caffeine; Carbon Tetrachloride; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hepatic Artery; Liver Cirrhosis, Experimental; Male; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Perfusion; Portal Vein; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Theophylline; Vascular Resistance; Vasodilation; Vasodilator Agents | 2010 |
Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture.
Topics: Acupuncture Analgesia; Adenosine; Afferent Pathways; Analysis of Variance; Animals; Disease Models, Animal; Mice; Nucleotidases; Pain; Pain Management; Peripheral Nervous System Diseases; Receptors, Purinergic P1; Sciatica; Statistics, Nonparametric | 2010 |
A new approach to assessing the structural total peripheral resistance amplifier in renal (Page) hypertension in conscious rabbits.
Topics: Acetylcholine; Adenosine; Angiotensin II; Animals; Blood Vessels; Cellophane; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Ganglionic Blockers; Hypertension, Renal; Male; Methoxamine; Rabbits; Vascular Resistance; Vasoconstrictor Agents; Vasodilator Agents | 2010 |
Plasticity of postsynaptic, but not presynaptic, GABAB receptors in SSADH deficient mice.
Topics: Adenosine; Animals; Baclofen; Disease Models, Animal; GABA Antagonists; gamma-Aminobutyric Acid; Mice; Mice, Knockout; Neuronal Plasticity; Organ Culture Techniques; Patch-Clamp Techniques; Presynaptic Terminals; Receptors, GABA-B; Succinate-Semialdehyde Dehydrogenase; Synaptic Transmission | 2010 |
Functional and morphological examinations of P1A1 purinoceptors in the normal and inflamed urinary bladder of the rat.
Topics: Adenosine; Animals; Cystitis; Disease Models, Animal; Drug Resistance; Inflammation Mediators; Male; Muscle Contraction; Muscle, Smooth; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Urinary Bladder | 2011 |
Engineering human mesenchymal stem cells to release adenosine using miRNA technology.
Topics: Adenosine; Adenosine Kinase; Animals; Cell Line; Disease Models, Animal; Genetic Vectors; Humans; Lentivirus; Male; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; MicroRNAs; RNA Interference; Seizures | 2010 |
Adjunctive treatment with ticagrelor, but not clopidogrel, added to tPA enables sustained coronary artery recanalisation with recovery of myocardium perfusion in a canine coronary thrombosis model.
Topics: Adenosine; Animals; Bleeding Time; Blood Coagulation; Clopidogrel; Coronary Circulation; Coronary Thrombosis; Disease Models, Animal; Dogs; Drug Therapy, Combination; Echocardiography; Female; Fibrinolytic Agents; Laser-Doppler Flowmetry; Male; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Recurrence; Thrombolytic Therapy; Ticagrelor; Ticlopidine; Time Factors; Tissue Plasminogen Activator | 2010 |
Continuous local intrahippocampal delivery of adenosine reduces seizure frequency in rats with spontaneous seizures.
Topics: Adenosine; Animals; Anticonvulsants; Catheterization; Disease Models, Animal; Drug Delivery Systems; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal Lobe; Functional Laterality; Hippocampus; Humans; Injections, Intraperitoneal; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Stereotaxic Techniques | 2010 |
Improved rat steatotic and nonsteatotic liver preservation by the addition of epidermal growth factor and insulin-like growth factor-I to University of Wisconsin solution.
Topics: Adenosine; Allopurinol; Animals; Cell Survival; Cold Ischemia; Disease Models, Animal; Epidermal Growth Factor; Fatty Liver; Glutathione; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Insulin; Insulin-Like Growth Factor I; Liver; Liver Transplantation; Organ Preservation; Organ Preservation Solutions; Perfusion; PPAR gamma; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Raffinose; Rats; Rats, Zucker; Recombinant Proteins; Reperfusion Injury; Time Factors | 2010 |
Protective effects of adenosine in rabbit sinoatrial node ischemia-reperfusion model in vivo: control of arrhythmia by hyperpolarization-activated cyclic nucleotide-gated (HCN)4 channels.
Topics: Adenosine; Animals; Arrhythmias, Cardiac; Creatine Kinase; Cyclic Nucleotide-Gated Cation Channels; Disease Models, Animal; Female; Male; Malondialdehyde; Myocardial Reperfusion Injury; Myocardium; Protective Agents; Rabbits; Sinoatrial Node; Superoxide Dismutase; Troponin T; Ultrasonography | 2011 |
Control of enteric neuromuscular functions by purinergic A(3) receptors in normal rat distal colon and experimental bowel inflammation.
Topics: Adenosine; Adenosine Deaminase; Animals; Benzenesulfonates; Carbachol; Colitis; Colon; Disease Models, Animal; Electric Stimulation; Fluorescent Antibody Technique; Male; Myenteric Plexus; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A3; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2010 |
Development of a new tacaribe arenavirus infection model and its use to explore antiviral activity of a novel aristeromycin analog.
Topics: Adenosine; Animals; Antiviral Agents; Arenaviridae Infections; Arenaviruses, New World; Chlorocebus aethiops; Cricetinae; Disease Models, Animal; Female; Humans; Male; Mesocricetus; Mice; Mice, Knockout; Vero Cells; Virus Replication | 2010 |
Manipulation of adenosine kinase affects sleep regulation in mice.
Topics: Adenosine; Adenosine Kinase; Animals; Cytoplasm; Disease Models, Animal; Electroencephalography; Isoenzymes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Neurotransmitter Agents; Signal Transduction; Sleep; Sleep Deprivation | 2010 |
Carotid body function in aged rats: responses to hypoxia, ischemia, dopamine, and adenosine.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Aging; Animals; Carotid Body; Cyclic AMP; Disease Models, Animal; Dopamine; Dopamine Antagonists; Hypoxia; Ischemia; Male; Pulmonary Ventilation; Rats; Rats, Wistar; Receptor, Adenosine A2A | 2011 |
Endogenous adenosine A1 receptor activation underlies the transient post-ischemic rhythmic delta EEG activity.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Delta Rhythm; Disease Models, Animal; Electrocardiography; Electroencephalography; Heart Rate; Ischemic Attack, Transient; Male; Rats; Rats, Wistar; Receptor, Adenosine A1; Statistics, Nonparametric; Theophylline; Xanthines | 2011 |
Differential recruitment of high affinity A1 and A2A adenosine receptors in the control of colonic neuromuscular function in experimental colitis.
Topics: 5'-Nucleotidase; Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Benzenesulfonates; Colitis; Colon; Disease Models, Animal; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptors, Adenosine A2; Xanthines | 2011 |
Contribution of adenosine A(2A) and A(2B) receptors to ischemic coronary dilation: role of K(V) and K(ATP) channels.
Topics: 4-Aminopyridine; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Coronary Circulation; Disease Models, Animal; Dogs; Flavins; Glyburide; Hyperemia; KATP Channels; Male; Myocardial Ischemia; Phenethylamines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Pyrimidines; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Triazoles; Vasodilation | 2010 |
Ticagrelor effectively and reversibly blocks murine platelet P2Y12-mediated thrombosis and demonstrates a requirement for sustained P2Y12 inhibition to prevent subsequent neointima.
Topics: Adenosine; Animals; Bleeding Time; Blood Coagulation; Blood Platelets; Carotid Artery Injuries; Carotid Artery, Common; Carotid Stenosis; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrinolytic Agents; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thrombosis; Ticagrelor; Tunica Intima | 2010 |
Adenosine 2A receptor is protective against renal injury in MRL/lpr mice.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Blotting, Western; Disease Models, Animal; Disease Progression; Female; Gene Expression; Inflammation; Lupus Erythematosus, Systemic; Lupus Nephritis; Mice; Mice, Inbred MRL lpr; Phenethylamines; Receptor, Adenosine A2A; Reverse Transcriptase Polymerase Chain Reaction; RNA | 2011 |
Two-dimensional strain combined with adenosine stress echocardiography assessment of viable myocardium.
Topics: Adenosine; Analysis of Variance; Animals; Coronary Occlusion; Disease Models, Animal; Dogs; Echocardiography, Doppler, Color; Echocardiography, Stress; Myocardial Contraction; Myocardial Infarction; Myocardium; Predictive Value of Tests; ROC Curve; Tissue Survival; Ventricular Function, Left | 2011 |
Experimental pig model of old myocardial infarction with long survival leading to chronic left ventricular dysfunction and remodeling as evaluated by PET.
Topics: Adenosine; Animals; Chronic Disease; Coronary Vessels; Disease Models, Animal; Male; Myocardial Infarction; Positron-Emission Tomography; Survival Rate; Swine; Ventricular Dysfunction, Left; Ventricular Remodeling | 2011 |
Adenosine A(2A) receptor activation prevents progressive kidney fibrosis in a model of immune-associated chronic inflammation.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Anti-Inflammatory Agents; Autoantibodies; Disease Models, Animal; Extracellular Matrix Proteins; Fibrosis; Glomerulonephritis; Inflammation Mediators; Kidney; Macrophages; Male; Phenethylamines; Rats; Rats, Inbred WKY; Receptor, Adenosine A2A; Severity of Illness Index; Time Factors; Triazines; Triazoles | 2011 |
Suppression of inflammation response by a novel A₃ adenosine receptor agonist thio-Cl-IB-MECA through inhibition of Akt and NF-κB signaling.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; beta Catenin; Cell Line; Disease Models, Animal; Endotoxemia; Humans; Interleukin-1beta; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred ICR; NF-kappa B; Nitric Oxide Synthase Type II; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Receptor, Adenosine A3; Signal Transduction; Tumor Necrosis Factor-alpha | 2011 |
Evaluation of adenosine preconditioning with 99mTc-His10-annexin V in a porcine model of myocardium ischemia and reperfusion injury: preliminary study.
Topics: Adenosine; Animals; Annexin A5; Caspase 3; Cell Death; Disease Models, Animal; Enzyme Activation; Feasibility Studies; Female; Histidine; Humans; Ischemic Preconditioning, Myocardial; Jurkat Cells; Male; Mice; Myocardial Reperfusion Injury; Organotechnetium Compounds; Rabbits; Radiochemistry; Swine; Tomography, Emission-Computed, Single-Photon | 2011 |
Impaired erectile function in CD73-deficient mice with reduced endogenous penile adenosine production.
Topics: 5'-Nucleotidase; Adenosine; Animals; Disease Models, Animal; Erectile Dysfunction; Male; Mice; Mice, Inbred C57BL; Penile Erection; Penis | 2011 |
Assessment of coronary microcirculation in a swine animal model.
Topics: Adenosine; Analysis of Variance; Animals; Aorta; Area Under Curve; Atrial Function, Right; Blood Pressure; Coronary Angiography; Coronary Artery Disease; Coronary Circulation; Disease Models, Animal; Fractional Flow Reserve, Myocardial; Hemodynamics; Hyperemia; Linear Models; Male; Microcirculation; Predictive Value of Tests; Severity of Illness Index; Swine; Time Factors; Vascular Resistance; Vasodilator Agents | 2011 |
Sex differences in the electrophysiological characteristics of pulmonary veins and left atrium and their clinical implication in atrial fibrillation.
Topics: Acetylcholine; Action Potentials; Adenosine; Animals; Atrial Fibrillation; Autonomic Nervous System; Cardiotonic Agents; Disease Models, Animal; Electrophysiologic Techniques, Cardiac; Female; Heart Atria; Isoproterenol; Male; Pulmonary Veins; Rabbits; Sex Characteristics; Vasodilator Agents | 2011 |
Cilostazol protects the heart against ischaemia reperfusion injury in a rabbit model of myocardial infarction: focus on adenosine, nitric oxide and mitochondrial ATP-sensitive potassium channels.
Topics: Adenosine; Animals; Cardiotonic Agents; Cilostazol; Decanoic Acids; Disease Models, Animal; Drug Evaluation, Preclinical; Enzyme Inhibitors; Humans; Hydroxy Acids; Myocardial Infarction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Potassium Channel Blockers; Purinergic P1 Receptor Antagonists; Rabbits; Reperfusion Injury; Superoxides; Tetrazoles; Theophylline | 2011 |
Ticagrelor inhibits adenosine uptake in vitro and enhances adenosine-mediated hyperemia responses in a canine model.
Topics: Acute Coronary Syndrome; Adenosine; Animals; Cell Line; Cell Line, Tumor; Coronary Circulation; Dipyridamole; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Erythrocytes; Female; Humans; Hyperemia; Male; Purinergic P2Y Receptor Antagonists; Rats; Ticagrelor | 2012 |
A new drug design targeting the adenosinergic system for Huntington's disease.
Topics: Adenosine; Animals; Disease Models, Animal; Drug Design; Drugs, Chinese Herbal; Equilibrative Nucleoside Transporter 1; Female; Humans; Huntington Disease; Male; Mice; Mice, Knockout; Models, Molecular; PC12 Cells; Peptides; Plant Extracts; Rats; Receptor, Adenosine A2A; Trinucleotide Repeat Expansion | 2011 |
Complex I syndrome in myocardial stunning and the effect of adenosine.
Topics: Adenosine; Animals; Cell Respiration; Disease Models, Animal; Electron Transport Complex I; Heart Ventricles; Lipid Peroxidation; Mitochondria, Heart; Myocardial Stunning; Nitric Oxide Synthase; Oxygen Consumption; Rabbits; Reperfusion Injury; Superoxide Dismutase | 2011 |
The interactions of nitric oxide and adenosine on penicillin-induced epileptiform activity in rats.
Topics: Action Potentials; Adenosine; Animals; Brain Waves; Disease Models, Animal; Drug Interactions; Electroencephalography; Enzyme Inhibitors; Epilepsy; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Penicillins; Rats; Rats, Wistar; Theophylline | 2011 |
Adenosine A₂A and A₂B receptors are both required for adenosine A₁ receptor-mediated cardioprotection.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Analysis of Variance; Animals; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Perfusion; Receptor Cross-Talk; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Time Factors; Ventricular Function, Left; Ventricular Pressure | 2011 |
Interleukin-6 contributes to inflammation and remodeling in a model of adenosine mediated lung injury.
Topics: Adenosine; Adenosine Deaminase; Animals; Antibodies, Neutralizing; Disease Models, Animal; Epithelial Cells; Female; Gene Knockout Techniques; Interleukin-6; Lung Injury; Male; Mice; Pneumonia; Pulmonary Alveoli; Pulmonary Fibrosis; STAT3 Transcription Factor | 2011 |
Differential neuroprotection by A(1) receptor activation and A(2A) receptor inhibition following pilocarpine-induced status epilepticus.
Topics: Adenosine; Analysis of Variance; Animals; Brain; Cell Count; Disease Models, Animal; Drug Interactions; Fluoresceins; Male; Nerve Degeneration; Neuroprotective Agents; Organic Chemicals; Phenylisopropyladenosine; Pilocarpine; Pyrimidines; Rats; Rats, Wistar; Reaction Time; Receptor, Adenosine A1; Receptor, Adenosine A2A; Status Epilepticus; Triazoles | 2011 |
Ecto-5'-nucleotidase (CD73) decreases mortality and organ injury in sepsis.
Topics: 5'-Nucleotidase; Adenosine; Animals; Blotting, Western; Cell Separation; Chemokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Mice; Mice, Knockout; Sepsis | 2011 |
Rewarding electrical brain stimulation in rats after peripheral nerve injury: decreased facilitation by commonly abused prescription opioids.
Topics: Adenosine; Amines; Analgesics; Analgesics, Opioid; Animals; Brain; Clonidine; Cyclohexanecarboxylic Acids; Disease Models, Animal; Electric Stimulation; Fentanyl; Gabapentin; gamma-Aminobutyric Acid; Hydromorphone; Injections, Spinal; Male; Methadone; Oxycodone; Peripheral Nerve Injuries; Rats; Rats, Inbred F344; Reward | 2011 |
BF061, a novel antiplatelet and antithrombotic agent targeting P2Y₁₂ receptor and phosphodiesterase.
Topics: Adenosine; Adenosine Monophosphate; Animals; Disease Models, Animal; Drug Synergism; Enzyme Inhibitors; Fibrinolytic Agents; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Phosphoric Diester Hydrolases; Platelet Activation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Thrombosis | 2011 |
Inactivation of CD73 promotes atherogenesis in apolipoprotein E-deficient mice.
Topics: 5'-Nucleotidase; Adenosine; Animals; Aorta; Apolipoproteins E; Atherosclerosis; Chemokine CCL2; Cholesterol; Disease Models, Animal; Disease Progression; Fatty Acids, Nonesterified; Gene Expression Profiling; GPI-Linked Proteins; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligonucleotide Array Sequence Analysis; T-Lymphocytes; Time Factors; Triglycerides | 2011 |
Local disruption of glial adenosine homeostasis in mice associates with focal electrographic seizures: a first step in epileptogenesis?
Topics: Adenosine; Adenosine Kinase; Amygdala; Animals; Disease Models, Animal; Electroencephalography; Gene Expression Regulation; Gliosis; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Neuroglia; Seizures; Time Factors | 2012 |
Activation of adenosine A1 receptor attenuates tumor necrosis factor-α induced hypertrophy of cardiomyocytes.
Topics: ADAM Proteins; ADAM17 Protein; Adenosine; Adenosine A1 Receptor Agonists; Animals; Animals, Newborn; Aorta; Aortic Valve Stenosis; Cardiomyopathy, Hypertrophic; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Ligation; Lung; Male; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Organ Size; Rats; Receptor, Adenosine A1; Receptors, Tumor Necrosis Factor, Type I; Signal Transduction; Tumor Necrosis Factor-alpha | 2011 |
Ecto-ATPase inhibition: ATP and adenosine release under physiological and ischemic in vivo conditions in the rat striatum.
Topics: Adenosine; Adenosine Triphosphatases; Adenosine Triphosphate; Analysis of Variance; Animals; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Infarction, Middle Cerebral Artery; Male; Membrane Transport Proteins; Microdialysis; Microscopy, Immunoelectron; Rats; Rats, Wistar; Subcellular Fractions; Synaptophysin; Time Factors | 2012 |
Antilipogenic and anti-inflammatory activities of Codonopsis lanceolata in mice hepatic tissues after chronic ethanol feeding.
Topics: Adenosine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cholesterol; Codonopsis; Disease Models, Animal; Ethanol; Fatty Liver, Alcoholic; Gene Expression Regulation; Lipid Regulating Agents; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Plant Extracts; Receptors, Adiponectin; Signal Transduction; Toll-Like Receptors; Triglycerides | 2012 |
Enhanced actions of adenosine in medial entorhinal cortex layer II stellate neurons in temporal lobe epilepsy are mediated via A(1)-receptor activation.
Topics: Action Potentials; Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Disease Models, Animal; Electric Stimulation; Entorhinal Cortex; Epilepsy, Temporal Lobe; Male; Neurons; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptors, Adenosine A2 | 2012 |
Acute down-regulation of adenosine A(1) receptor activity in status epilepticus.
Topics: Adenosine; Animals; Disease Models, Animal; Down-Regulation; Electric Stimulation; Electroencephalography; Hippocampus; Male; Rats; Rats, Wistar; Receptor, Adenosine A1; Status Epilepticus | 2012 |
[Effect of ischemic postconditioning on oxidative stress and structural tissue changes in intestinal warm ischemic and autotransplantation models].
Topics: Adenosine; Allopurinol; Animals; Antioxidants; Disease Models, Animal; Glutathione; Insulin; Intestines; Ischemia; Ischemic Postconditioning; Laparotomy; Lipid Peroxidation; Malondialdehyde; Organ Preservation Solutions; Oxidative Stress; Raffinose; Reperfusion Injury; Superoxide Dismutase; Sus scrofa; Time Factors; Transplantation, Autologous; Warm Ischemia | 2011 |
Adenosine A2A receptors in the nucleus accumbens bi-directionally alter cocaine seeking in rats.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Analysis of Variance; Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Disease Models, Animal; Dopamine Agonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Extinction, Psychological; Locomotion; Male; Nucleus Accumbens; Phenethylamines; Purinergic P2X Receptor Antagonists; Quinpirole; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Reinforcement, Psychology; Self Administration; Sucrose; Sweetening Agents; Xanthines | 2012 |
Relationship between ischemia/reperfusion injury and the stimulus of fibrogenesis in an experimental model: comparison among different preservation solutions.
Topics: Acetylcysteine; Adenosine; Alanine Transaminase; Allopurinol; Animals; Aspartate Aminotransferases; Biomarkers; Catalase; Disease Models, Animal; Fructosediphosphates; Glutathione; Insulin; L-Lactate Dehydrogenase; Liver; Liver Cirrhosis; Liver Transplantation; Male; Organ Preservation Solutions; Raffinose; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Renin; Reperfusion Injury; Thiobarbituric Acid Reactive Substances; Time Factors; Transforming Growth Factor beta1 | 2011 |
Pinacidil pretreatment improves vascular reactivity after shock through PKCα and PKCε in rats.
Topics: Adenosine; Animals; Calcium; Disease Models, Animal; Female; Fluid Therapy; Male; Mesenteric Artery, Superior; Pinacidil; Protein Kinase C-alpha; Protein Kinase C-epsilon; Protein Transport; Rats; Rats, Wistar; Receptor, Adenosine A1; Resuscitation; Shock, Hemorrhagic; Survival Rate; Vasodilator Agents; Xanthines | 2012 |
Neurabin scaffolding of adenosine receptor and RGS4 regulates anti-seizure effect of endogenous adenosine.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Animals, Newborn; Cell Death; Cells, Cultured; Cricetinae; Cricetulus; Disease Models, Animal; Electroencephalography; Fluoresceins; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microfilament Proteins; Models, Biological; Nerve Tissue Proteins; Organic Chemicals; Phenylisopropyladenosine; Receptor, Adenosine A1; RGS Proteins; Seizures; Signal Transduction; Sulfonamides; Time Factors; Transfection; Xanthines | 2012 |
The brain in vivo expresses the 2',3'-cAMP-adenosine pathway.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Adenine Nucleotides; Adenosine; Adenosine Monophosphate; Adult; Animals; Brain; Brain Injuries; Cyclic AMP; Disease Models, Animal; Extracellular Fluid; Female; Gene Expression Regulation; Glasgow Coma Scale; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Signal Transduction; Young Adult | 2012 |
Severe acute intermittent hypoxia elicits phrenic long-term facilitation by a novel adenosine-dependent mechanism.
Topics: Acute Disease; Adenosine; Adenosine A2 Receptor Antagonists; Animals; Blood Pressure; Carbon Dioxide; Disease Models, Animal; Hypoxia; Injections, Spinal; Lung; Male; Neuronal Plasticity; Oxygen; Phrenic Nerve; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Serotonin, 5-HT2; Respiration; Serotonin; Serotonin 5-HT2 Receptor Antagonists; Severity of Illness Index; Time Factors | 2012 |
Anti-inflammatory effects of purine nucleosides, adenosine and inosine, in a mouse model of pleurisy: evidence for the role of adenosine A2 receptors.
Topics: Adenosine; Animals; Anti-Inflammatory Agents; Carrageenan; Cytokines; Disease Models, Animal; Female; Inosine; Leukocytes; Mice; Pleurisy; Purine Nucleosides; Receptors, Adenosine A2 | 2012 |
Beneficial metabolic effects of 2',3',5'-tri-acetyl-N6- (3-hydroxylaniline) adenosine in the liver and plasma of hyperlipidemic hamsters.
Topics: Adenosine; Animals; Azo Compounds; Biomarkers; Cholesterol, HDL; Cholesterol, LDL; Cricetinae; Disease Models, Animal; Hyperlipidemias; Liver; Metabolomics; Principal Component Analysis; Triglycerides; Ultrasonography | 2012 |
Noninvasive limb remote ischemic preconditioning contributes neuroprotective effects via activation of adenosine A1 receptor and redox status after transient focal cerebral ischemia in rats.
Topics: Adenosine; Analysis of Variance; Animals; Brain Infarction; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; Extremities; Glutathione; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Ischemic Preconditioning; Lipid Peroxidation; Male; Nervous System Diseases; Neuroprotective Agents; Nitrites; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Severity of Illness Index; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Xanthines | 2012 |
Protective role of nitric oxide induced by ischemic preconditioning on cold ischemic-reperfusion injury of rat liver graft.
Topics: Adenosine; Alanine Transaminase; Animals; Anticoagulants; Apoptosis; Bile; Cold Ischemia; Disease Models, Animal; Endothelial Cells; Enzyme Inhibitors; Heparin; Ischemic Preconditioning; Liver; Liver Transplantation; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase; Superoxides; Time Factors; Tumor Necrosis Factor-alpha | 2012 |
Adenosine augmentation ameliorates psychotic and cognitive endophenotypes of schizophrenia.
Topics: Adenosine; Adenosine Kinase; Amphetamines; Animals; Antipsychotic Agents; Basal Ganglia; Cell Transplantation; Cells, Cultured; Cognition Disorders; Cricetinae; Disease Models, Animal; Endophenotypes; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morpholines; Psychotic Disorders; Pyrimidines; Receptor, Adenosine A2A; Schizophrenia; Schizophrenic Psychology | 2012 |
A2A adenosine receptor agonists reduce both high-palatability and low-palatability food intake in female rats.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Appetite Depressants; Appetite Regulation; Behavior, Animal; Binge-Eating Disorder; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Energy Intake; Feeding Behavior; Female; Food Preferences; Nerve Tissue Proteins; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Satiety Response; Thionucleosides | 2012 |
Impact of iterative reconstruction on CNR and SNR in dynamic myocardial perfusion imaging in an animal model.
Topics: Adenosine; Algorithms; Animals; Balloon Occlusion; Cardiac-Gated Imaging Techniques; Contrast Media; Coronary Artery Disease; Disease Models, Animal; Iopamidol; Myocardial Perfusion Imaging; Prospective Studies; Radiation Dosage; Radiographic Image Interpretation, Computer-Assisted; Signal-To-Noise Ratio; Statistics, Nonparametric; Swine; Tomography, X-Ray Computed | 2012 |
Deletion of the BDNF truncated receptor TrkB.T1 delays disease onset in a mouse model of amyotrophic lateral sclerosis.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Amyotrophic Lateral Sclerosis; Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Disease Progression; Mice; Phenethylamines; Receptor, trkB; Superoxide Dismutase | 2012 |
Reversal of acute coagulopathy during hypotensive resuscitation using small-volume 7.5% NaCl adenocaine and Mg2+ in the rat model of severe hemorrhagic shock.
Topics: Adenosine; Animals; Blood Coagulation Disorders; Disease Models, Animal; Drug Combinations; Hemodynamics; Lidocaine; Magnesium; Male; Partial Thromboplastin Time; Prothrombin Time; Rats; Resuscitation; Shock, Hemorrhagic; Sodium Chloride | 2012 |
Increasing the therapeutic index of 5-fluorouracil and 6-thioguanine by targeting loss of MTAP in tumor cells.
Topics: Adenosine; Animals; Cell Line; Cell Line, Tumor; Disease Models, Animal; Fibrosarcoma; Fluorouracil; Humans; Mesothelioma; Mice; Mice, Inbred C57BL; Neoplasms; Purine-Nucleoside Phosphorylase; Thioguanine; Thionucleosides | 2012 |
Quantification of myocardial blood flow by adenosine-stress CT perfusion imaging in pigs during various degrees of stenosis correlates well with coronary artery blood flow and fractional flow reserve.
Topics: Adenosine; Animals; Blood Flow Velocity; Coronary Angiography; Coronary Circulation; Coronary Stenosis; Disease Models, Animal; Exercise Test; Fractional Flow Reserve, Myocardial; Imaging, Three-Dimensional; Myocardial Perfusion Imaging; Random Allocation; Sensitivity and Specificity; Severity of Illness Index; Swine; Tomography, X-Ray Computed | 2013 |
Adenocaine and Mg(2+) reduce fluid requirement to maintain hypotensive resuscitation and improve cardiac and renal function in a porcine model of severe hemorrhagic shock*.
Topics: Adenosine; Animals; Disease Models, Animal; Drug Combinations; Female; Fluid Therapy; Heart; Hypotension; Kidney; Lidocaine; Magnesium; Resuscitation; Severity of Illness Index; Shock, Hemorrhagic; Swine | 2012 |
Lack of ecto-5'-nucleotidase (CD73) promotes arteriogenesis.
Topics: 5'-Nucleotidase; Adenosine; Animals; Arteries; Capillaries; Collateral Circulation; Disease Models, Animal; Energy Metabolism; GPI-Linked Proteins; Hindlimb; Ischemia; Magnetic Resonance Angiography; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; Neovascularization, Physiologic; Recovery of Function; Regional Blood Flow; Time Factors | 2013 |
Neuropathic pain and reactive gliosis are reversed by dialdehydic compound in neuropathic pain rat models.
Topics: Adenosine; Adenosine Triphosphate; Affinity Labels; Aldehydes; Analgesics; Animals; Astrocytes; Chronic Disease; Disease Models, Animal; Drug Discovery; Gliosis; Hyperalgesia; Lumbar Vertebrae; Male; Microglia; Neuralgia; Rats; Rats, Sprague-Dawley; Spinal Cord | 2012 |
Different analgesic effects of adenosine between postoperative and neuropathic pain.
Topics: Adenosine; Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Spinal; Neuralgia; Pain, Postoperative; Rats; Rats, Wistar | 2013 |
Comparison between adenosine and isoflurane for assessing the coronary flow reserve in mouse models of left ventricular pressure and volume overload.
Topics: Adenosine; Animals; Coronary Circulation; Disease Models, Animal; Echocardiography, Doppler; Feasibility Studies; Hyperemia; Isoflurane; Male; Mice; Mice, Inbred C57BL; Myocardial Contraction; Predictive Value of Tests; Reproducibility of Results; Stroke Volume; Vasodilator Agents; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Pressure | 2012 |
Effect of adenosine on injury caused by ischemia and reperfusion in rats: functional and morphologic study.
Topics: Adenosine; Animals; Cytoprotection; Disease Models, Animal; Electric Stimulation; Enteric Nervous System; Gastrointestinal Agents; Gastrointestinal Motility; Jejunum; Potassium Chloride; Rats; Rats, Wistar; Reperfusion Injury | 2012 |
Clinically relevant animal models needed to advance state of the art fluid resuscitation*.
Topics: Adenosine; Animals; Disease Models, Animal; Drug Combinations; Female; Fluid Therapy; Heart; Hypotension; Kidney; Lidocaine; Magnesium; Resuscitation; Shock, Hemorrhagic | 2012 |
Ankle joint mobilization affects postoperative pain through peripheral and central adenosine A1 receptors.
Topics: Adenosine; Analysis of Variance; Animals; Ankle Joint; Caffeine; Clonidine; Disease Models, Animal; Fenclonine; Hyperalgesia; Male; Mice; Morphine; Pain, Postoperative; Receptor, Adenosine A1; Xanthines; Yohimbine | 2013 |
Cordyceps sinensis protects against renal ischemia/reperfusion injury in rats.
Topics: Adenosine; Animals; Cellular Senescence; Chemokine CXCL12; Cordyceps; Creatine; Disease Models, Animal; Drugs, Chinese Herbal; Ki-67 Antigen; Kidney Diseases; Male; Protein Transport; Rats; Receptors, CXCR4; Reperfusion Injury | 2013 |
Interaction of SSR161421, a novel specific adenosine A(3) receptor antagonist with adenosine A(3) receptor agonists both in vitro and in vivo.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Aminoquinolines; Animals; Benzamides; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Disease Models, Animal; Drug Interactions; Edema; Histamine; Humans; Inhibitory Concentration 50; Male; Mice; Plasma; Receptors, Purinergic P1 | 2013 |
Adenosine A1 receptor agonist, N6-cyclohexyladenosine, protects myelin and induces remyelination in an experimental model of rat optic chiasm demyelination; electrophysiological and histopathological studies.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Demyelinating Diseases; Disease Models, Animal; Electrophysiological Phenomena; Male; Myelin Sheath; Nerve Regeneration; Neuroprotective Agents; Optic Chiasm; Rats; Rats, Wistar | 2013 |
5'-Phosphate and 5'-phosphonate ester derivatives of (N)-methanocarba adenosine with in vivo cardioprotective activity.
Topics: Adenosine; Animals; Cardiotonic Agents; Chromatography, High Pressure Liquid; Disease Models, Animal; Esters; Magnetic Resonance Spectroscopy; Mice; Myocardial Ischemia; Organophosphonates; Phosphates; Spectrometry, Mass, Electrospray Ionization | 2013 |
Antiepileptic drugs prevent changes in adenosine deamination during acute seizure episodes in adult zebrafish.
Topics: Adenine Nucleotides; Adenosine; Adenosine Deaminase; Amines; Animals; Anticonvulsants; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Female; Gabapentin; gamma-Aminobutyric Acid; Gene Expression; Male; Pentylenetetrazole; Phenytoin; Seizures; Valproic Acid; Zebrafish | 2013 |
Reduced sleep and low adenosinergic sensitivity in cacna1a R192Q mutant mice.
Topics: Adenosine; Analysis of Variance; Animals; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Disease Models, Animal; Electroencephalography; Electromyography; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1; Sleep Deprivation; Sleep Stages; Sleep, REM; Sodium Chloride | 2013 |
The adenosine A2A receptor agonist CGS 21680 decreases ethanol self-administration in both non-dependent and dependent animals.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Alcoholism; Analysis of Variance; Animals; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Ethanol; Food Preferences; Male; Mice; Mice, Knockout; Motivation; Phenethylamines; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptors, Adenosine A2; Reinforcement Schedule; Reward; Self Administration; Sucrose | 2013 |
[Adenosine receptors agonists mitigated PAH of rats induced by chronic hypoxia through reduction of renin activity/angiotensin II levels and increase of inducible nitric oxide synthase-nitric oxide levels].
Topics: Adenosine; Angiotensin II; Animals; Disease Models, Animal; Endothelin-1; Hypertension, Pulmonary; Hypoxia; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Proliferating Cell Nuclear Antigen; Pulmonary Artery; Purinergic P1 Receptor Agonists; Random Allocation; Rats; Rats, Sprague-Dawley; Renin | 2012 |
A(2A) adenosine receptors are differentially modulated by pharmacological treatments in rheumatoid arthritis patients and their stimulation ameliorates adjuvant-induced arthritis in rats.
Topics: Adenosine; Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Models, Animal; Humans; Inflammation; Longitudinal Studies; Lymphocytes; Male; Methotrexate; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Receptors, Purinergic P1; Rituximab; Tumor Necrosis Factor-alpha; Up-Regulation | 2013 |
Ischemic post-conditioning and vasodilator therapy during standard cardiopulmonary resuscitation to reduce cardiac and brain injury after prolonged untreated ventricular fibrillation.
Topics: Adenosine; Animals; Brain Ischemia; Cardiotonic Agents; Disease Models, Animal; Echocardiography; Epinephrine; Heart Arrest; Ischemic Postconditioning; Models, Cardiovascular; Nitroprusside; Stroke Volume; Swine; Time Factors; Treatment Outcome; Vasoconstrictor Agents; Vasodilator Agents; Ventricular Fibrillation; Ventricular Function, Left | 2013 |
Impaired function of prejunctional adenosine A1 receptors expressed by perivascular sympathetic nerves in DOCA-salt hypertensive rats.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Desoxycorticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Hypertension; Immunohistochemistry; Male; Mesenteric Arteries; Mesenteric Veins; Neuroeffector Junction; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Sympathetic Nervous System; Synaptic Transmission; Vasoconstriction | 2013 |
Adenosine A1 receptor activation attenuates lung ischemia-reperfusion injury.
Topics: Adenosine; Analysis of Variance; Animals; Bronchoalveolar Lavage Fluid; Chemotaxis; Cytokines; Disease Models, Animal; Lung Transplantation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophil Infiltration; Peroxidase; Random Allocation; Receptor, Adenosine A1; Reperfusion Injury; Respiratory Function Tests | 2013 |
[Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage].
Topics: Adenosine; Animals; Concanavalin A; Disease Models, Animal; Hepatitis, Animal; Hepatitis, Autoimmune; Liver; Mice; Phenethylamines; Purinergic P1 Receptor Agonists | 2002 |
Seizure suppression by adenosine A(2A) receptor activation in a rat model of audiogenic brainstem epilepsy.
Topics: Adenosine; Animals; Brain Stem; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Reflex; Purinergic P1 Receptor Agonists; Rats; Rats, Mutant Strains; Receptor, Adenosine A2A | 2002 |
Enhanced release of adenosine in rat hind paw following spinal nerve ligation: involvement of capsaicin-sensitive sensory afferents.
Topics: Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine Kinase; Afferent Pathways; Animals; Capsaicin; Disease Models, Animal; Enzyme Inhibitors; Hyperalgesia; Male; Nerve Crush; Nerve Fibers, Unmyelinated; Neuralgia; Neurons, Afferent; Nociceptors; Oxidopamine; Peripheral Nerve Injuries; Peripheral Nerves; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Skin; Spinal Nerves; Sympathetic Fibers, Postganglionic | 2002 |
Effect of pretreatment with adenosine, diazoxide or ischemic preconditioning on ischemia- reperfusion injury in the limbs of rats.
Topics: Adenosine; Animals; Creatine Kinase; Diazoxide; Disease Models, Animal; Extremities; Ischemic Preconditioning; Male; Protective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2002 |
The adenosine A1 receptor agonist adenosine amine congener exerts a neuroprotective effect against the development of striatal lesions and motor impairments in the 3-nitropropionic acid model of neurotoxicity.
Topics: Adenosine; Animals; Behavior, Animal; Binding, Competitive; Body Weight; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Dystonia; Enkephalins; Hindlimb; Huntington Disease; In Vitro Techniques; Male; Mitochondria; Motor Activity; Neuroprotective Agents; Neurotoxins; Nitro Compounds; Propionates; Purinergic P1 Receptor Agonists; Rats; Rats, Inbred Lew; Reproducibility of Results; RNA, Messenger; Succinate Dehydrogenase; Synaptic Transmission; Treatment Outcome | 2002 |
Antioxidants modulate adenosine metabolism in rat mesangial cells cultured under high glucose conditions.
Topics: Adenosine; Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Captopril; Cell Culture Techniques; Disease Models, Animal; Fibroblasts; Free Radical Scavengers; Glomerular Mesangium; Glutathione; Hyperglycemia; Melatonin; Rats; Rats, Sprague-Dawley; Renal Circulation; Vasodilator Agents | 2002 |
The effect of insulin on expression level of nucleoside transporters in diabetic rats.
Topics: Adenosine; Animals; Diabetes Mellitus; Disease Models, Animal; Gene Expression; Insulin; Male; Nucleoside Transport Proteins; Rats; Rats, Wistar | 2003 |
Further insights into the no-reflow phenomenon after primary angioplasty in acute myocardial infarction: the role of microthromboemboli.
Topics: Adenosine; Angioplasty, Balloon, Coronary; Animals; Autoradiography; Contrast Media; Coronary Angiography; Coronary Thrombosis; Disease Models, Animal; Dogs; Echocardiography, Doppler, Color; Male; Models, Cardiovascular; Myocardial Infarction; Myocardial Reperfusion; Postoperative Complications; Predictive Value of Tests; Radiopharmaceuticals; Severity of Illness Index; Technetium; Treatment Outcome; Vasodilator Agents | 2003 |
Characterization of adenosine receptor(s) involved in adenosine-induced bronchoconstriction in an allergic mouse model.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adrenergic Agonists; Adrenergic Antagonists; Animals; Asthma; Bronchoconstriction; Disease Models, Animal; Hypersensitivity; Lung; Male; Mice; Mice, Inbred BALB C; Phenethylamines; Pyridines; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vasodilator Agents | 2003 |
Role of adenosine in drug-induced catatonia in mice.
Topics: Adenosine; Animals; Antiparkinson Agents; Brain; Carbidopa; Catatonia; Catechol O-Methyltransferase Inhibitors; Catechols; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Injections, Intraperitoneal; Levodopa; Male; Mice; Motor Activity; Perphenazine | 2002 |
Nucleotide-induced restoration of conjunctival chloride and fluid secretion in adenovirus type 5-infected pigmented rabbit eyes.
Topics: Adenosine; Adenoviridae; Adenoviridae Infections; Animals; Body Fluids; Chlorides; Conjunctiva; Disease Models, Animal; Eye Infections; Pigmentation; Purinergic Agonists; Rabbits; Uridine; Uridine Triphosphate | 2003 |
A3 adenosine receptor agonist IB-MECA reduces myocardial ischemia-reperfusion injury in dogs.
Topics: Adenosine; Anesthesia; Animals; Cardiotonic Agents; Coronary Circulation; Disease Models, Animal; Dogs; Iodine Radioisotopes; Myocardial Infarction; Myocardial Reperfusion Injury; Purinergic P1 Receptor Agonists; Radioligand Assay; Receptor, Adenosine A3; Receptors, Purinergic P1 | 2003 |
The adenosine A3 receptor agonist, N6-(3-iodobenzyl)-adenosine-5'-N-methyluronamide, is protective in two murine models of colitis.
Topics: Adenosine; Animals; Chemokine CCL4; Chemokine CXCL2; Chemokines; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Dose-Response Relationship, Drug; Gastrointestinal Hemorrhage; Interleukin-1; Interleukin-12; Interleukin-6; Macrophage Inflammatory Proteins; Male; Malondialdehyde; Mice; Mice, Inbred BALB C; Mice, Knockout; Peroxidase; Purinergic P1 Receptor Agonists; Receptor, Adenosine A3; Rectal Diseases; Weight Loss | 2003 |
Long-lasting anticryptosporidial activity of nitazoxanide in an immunosuppressed rat model.
Topics: Adenosine; Animals; Antiprotozoal Agents; Cryptosporidiosis; Cryptosporidium parvum; Disease Models, Animal; Feces; Immunocompromised Host; Male; Nitro Compounds; Parasite Egg Count; Paromomycin; Rats; Rats, Sprague-Dawley; Thiazoles | 2003 |
Tympanic membrane vessel revisited: a study in an animal model.
Topics: Acute Disease; Adenosine; Animals; Antigens; Coagulants; Disease Models, Animal; Immunohistochemistry; Isoantibodies; Male; Neovascularization, Pathologic; Otitis Media, Suppurative; Rats; Rats, Sprague-Dawley; Streptococcal Infections; Streptococcus pneumoniae; Time Factors; Tympanic Membrane; Vasodilator Agents; von Willebrand Factor | 2003 |
Seizure suppression by adenosine A1 receptor activation in a mouse model of pharmacoresistant epilepsy.
Topics: Adenosine; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Injections; Kainic Acid; Male; Mice; Mice, Inbred Strains; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1; Temporal Lobe | 2003 |
Hyperphosphaturia after kidney transplantation in syngeneic rats: effects on nephrocalcinosis and bone metabolism?
Topics: Adenosine; Allopurinol; Animals; Bone and Bones; Calcinosis; Disease Models, Animal; Glutathione; Insulin; Kidney Diseases; Kidney Transplantation; Male; Nephrectomy; Organ Preservation; Organ Preservation Solutions; Phosphates; Raffinose; Rats; Rats, Inbred Lew; Tissue and Organ Harvesting; Transplantation, Isogeneic; Urinalysis | 2003 |
Changes in nucleotide hydrolysis in rat blood serum induced by pentylenetetrazol-kindling.
Topics: 5'-Nucleotidase; Adenine Nucleotides; Adenosine; Animals; Apyrase; Biomarkers; Brain; Convulsants; Disease Models, Animal; Epilepsy; Female; Hydrolysis; Kindling, Neurologic; Nucleotidases; Pentylenetetrazole; Presynaptic Terminals; Rats; Rats, Wistar; Synaptic Transmission | 2003 |
A dual role of adenosine A2A receptors in 3-nitropropionic acid-induced striatal lesions: implications for the neuroprotective potential of A2A antagonists.
Topics: Adenosine; Animals; Body Weight; Cell Death; Corpus Striatum; Disease Models, Animal; Drug Administration Schedule; Encephalitis; Genetic Predisposition to Disease; Glutamic Acid; Huntington Disease; Male; Mice; Mice, Knockout; Neuroprotective Agents; Nitro Compounds; Phenethylamines; Propionates; Rats; Rats, Inbred Lew; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; RNA, Messenger; Signal Transduction; Survival Rate; Synapses; Xanthines | 2003 |
Integrated pharmacological preconditioning in combination with adenosine, a mitochondrial KATP channel opener and a nitric oxide donor.
Topics: Adenosine; Animals; Combined Modality Therapy; Coronary Circulation; Creatine Kinase; Diazoxide; Disease Models, Animal; Flavoproteins; Heart Rate; Ion Channel Gating; Ischemic Preconditioning; Male; Membrane Proteins; Models, Cardiovascular; Myocardial Contraction; Myocardial Ischemia; Myocytes, Cardiac; Necrosis; Nitric Oxide Donors; Oxidation-Reduction; Potassium Channels; Protein Kinase C; Rats; Rats, Sprague-Dawley; Vasodilator Agents; Ventricular Function, Left; Ventricular Pressure | 2003 |
Direct effects of dobutamine on the coronary microcirculation: comparison with adenosine using myocardial contrast echocardiography.
Topics: Adenosine; Adrenergic beta-Agonists; Animals; Blood Flow Velocity; Blood Pressure; Coronary Circulation; Coronary Stenosis; Disease Models, Animal; Dobutamine; Dogs; Echocardiography; Endocardium; Heart Rate; Models, Cardiovascular; Myocardium; Pericardium; Statistics as Topic; Vascular Resistance; Vasodilator Agents | 2003 |
Novel N6-substituted adenosine 5'-N-methyluronamides with high selectivity for human adenosine A3 receptors reduce ischemic myocardial injury.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; CHO Cells; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Furans; Humans; Iodine Radioisotopes; Isoxazoles; Myocardial Infarction; Myocardial Reperfusion Injury; Purines; Rabbits; Radioligand Assay; Receptor, Adenosine A3; Sertraline; Transfection | 2003 |
Electrophysiologic characterization and postnatal development of ventricular pre-excitation in a mouse model of cardiac hypertrophy and Wolff-Parkinson-White syndrome.
Topics: Adenosine; Age Factors; AMP-Activated Protein Kinases; Animals; Anti-Arrhythmia Agents; Biopsy; Cardiomegaly; Disease Models, Animal; Disease Progression; Electrocardiography; Electrophysiologic Techniques, Cardiac; Electrophysiology; Genotype; Heart Conduction System; Mice; Mice, Transgenic; Multienzyme Complexes; Mutation, Missense; Phenotype; Pre-Excitation Syndromes; Procainamide; Protein Serine-Threonine Kinases; Single-Blind Method; Ventricular Dysfunction; Wolff-Parkinson-White Syndrome | 2003 |
Comparison of adenosine, isoflurane, and desflurane on myocardial tissue oxygen pressure during coronary artery constriction in dogs.
Topics: Adenosine; Animals; Blood Pressure; Carbon Dioxide; Constriction, Pathologic; Coronary Circulation; Coronary Stenosis; Desflurane; Disease Models, Animal; Dogs; Heart Rate; Hypotension; Isoflurane; Male; Models, Cardiovascular; Myocardium; Oxygen; Oxygen Consumption; Prospective Studies; Random Allocation; Vasodilator Agents | 2003 |
PPARgamma activation, by reducing oxidative stress, increases NO bioavailability in coronary arterioles of mice with Type 2 diabetes.
Topics: Acetylcholine; Adenosine; Animals; Arterioles; Biological Availability; Coronary Vessels; Diabetes Mellitus, Type 2; Disease Models, Animal; Hypoglycemic Agents; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Oxidative Stress; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazolidinediones; Transcription Factors; Vasodilation | 2004 |
Inhibition of primary colon carcinoma growth and liver metastasis by the A3 adenosine receptor agonist CF101.
Topics: Adenosine; Administration, Oral; Animals; Biological Availability; Carcinoma; Cell Division; Colonic Neoplasms; Disease Models, Animal; Humans; Liver Neoplasms; Mice; Mice, Inbred BALB C; Purinergic P1 Receptor Agonists; Transplantation, Heterologous; Tumor Cells, Cultured | 2003 |
Coronary flow reserve in the newborn lamb: an intracoronary Doppler guide wire study.
Topics: Acute Disease; Adenosine; Animals; Animals, Newborn; Carbon Dioxide; Coronary Circulation; Disease Models, Animal; Female; Hypoxia; Male; Oxygen; Sheep; Ultrasonography, Doppler; Ultrasonography, Interventional; Vasodilator Agents | 2004 |
Adenosine A2A receptors and depression.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Antidepressive Agents; Behavior, Animal; Caffeine; Depression; Disease Models, Animal; Dopamine Antagonists; Drug Interactions; Haloperidol; Mice; Mice, Knockout; Motor Activity; Neurotransmitter Agents; Parkinsonian Disorders; Purines; Pyrimidines; Receptor, Adenosine A2A; Triazines; Triazoles | 2003 |
Discovery of nonxanthine adenosine A2A receptor antagonists for the treatment of Parkinson's disease.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Humans; Ligands; Mefloquine; Mice; Motor Activity; Neuroprotective Agents; Parkinsonian Disorders; Phenethylamines; Purines; Pyrimidines; Radioligand Assay; Rats; Triazines; Triazoles | 2003 |
Effects of ischemic preconditioning on myocardial protective on cardiac surgery: possibility of ischemic preconditioning and adenosine administration.
Topics: Adenosine; Animals; Biopsy, Needle; Cardiac Surgical Procedures; Combined Modality Therapy; Disease Models, Animal; Female; Heart Arrest, Induced; Immunohistochemistry; Ischemic Preconditioning, Myocardial; Male; Myocardial Contraction; Myocardial Reperfusion Injury; Postoperative Complications; Random Allocation; Reference Values; Risk Assessment; Sensitivity and Specificity; Sus scrofa; Treatment Outcome; Troponin T | 2003 |
Dust mite-induced asthma in cynomolgus monkeys.
Topics: Adenosine; Aerosols; Allergens; Animals; Asthma; Bronchial Provocation Tests; Cytokines; Disease Models, Animal; Dust; Histamine; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Immunization; Immunoglobulin E; Immunoglobulin G; Lung; Macaca fascicularis; Mites; Respiratory Function Tests; Respiratory Hypersensitivity; Respiratory System; Th2 Cells; Time Factors | 2004 |
Airway hyperresponsiveness to bradykinin induced by allergen challenge in actively sensitised Brown Norway rats.
Topics: Adenosine; Adrenergic beta-1 Receptor Agonists; Adrenergic beta-2 Receptor Antagonists; Animals; Arachidonate 5-Lipoxygenase; Bradykinin; Bronchial Hyperreactivity; Bronchoconstriction; Bronchoconstrictor Agents; Disease Models, Animal; Endopeptidases; Lung; Male; Mast Cells; Methacholine Chloride; Ovalbumin; Rats; Rats, Inbred BN; Receptors, Muscarinic; Tachykinins | 2004 |
Pretreatment effect of adenosine on activation of NF-kappaB and level of TNF-alpha during myocardial ischemia and reperfusion in rats.
Topics: Adenosine; Analysis of Variance; Animals; Blotting, Western; Confidence Intervals; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reperfusion Injury; NF-kappa B; Random Allocation; Rats; Rats, Sprague-Dawley; Reference Values; Sensitivity and Specificity; Tumor Necrosis Factor-alpha | 2004 |
Adenosine administration produces an antidepressant-like effect in mice: evidence for the involvement of A1 and A2A receptors.
Topics: Adenosine; Animals; Antidepressive Agents; Caffeine; Depressive Disorder; Disease Models, Animal; Female; Male; Mice; Motor Activity; Receptor, Adenosine A1; Receptor, Adenosine A2A; Stress, Psychological; Triazines; Triazoles; Xanthines | 2004 |
Effect of the K+(ATP) channel opener, KCO912, on baseline and allergen induced airway hyperresponsiveness in allergic rabbits.
Topics: Adenosine; Adenosine Triphosphate; Allergens; Alternaria; Animals; Antigens, Fungal; Benzopyrans; Bronchial Hyperreactivity; Disease Models, Animal; Dose-Response Relationship, Drug; Hypersensitivity; Piperidines; Potassium Channels; Rabbits | 2004 |
Stimulation of adenosine A2A receptors elicits zif/268 and NMDA epsilon2 subunit mRNA expression in cortex and striatum of the "weaver" mutant mouse, a genetic model of nigrostriatal dopamine deficiency.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Autoradiography; Binding Sites; Cell Count; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; DNA-Binding Proteins; Dopamine; Dopamine Agonists; Dopamine Antagonists; Early Growth Response Protein 1; Gene Expression; Immediate-Early Proteins; In Situ Hybridization; Mice; Mice, Neurologic Mutants; Phenethylamines; Protein Subunits; Quinpirole; Raclopride; Receptor, Adenosine A2B; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Staining and Labeling; Transcription Factors | 2004 |
Patent ductus arteriosus remodels cardiac sensory neuronal chemotransduction.
Topics: Action Potentials; Adenosine; Adrenergic beta-Agonists; Aging; Animals; Animals, Newborn; Chemoreceptor Cells; Disease Models, Animal; Ductus Arteriosus, Patent; Female; Heart Ventricles; Male; Mechanoreceptors; Neural Conduction; Nodose Ganglion; Physical Stimulation; Sensory Receptor Cells; Signal Transduction; Sodium Channel Blockers; Sus scrofa; Visceral Afferents | 2004 |
A1 adenosine receptor upregulation and activation attenuates neuroinflammation and demyelination in a model of multiple sclerosis.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Caffeine; Disease Models, Animal; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Inflammation; Inflammation Mediators; Interleukin-1; Macrophages; Matrix Metalloproteinase 12; Metalloendopeptidases; Mice; Mice, Knockout; Microglia; Multiple Sclerosis; Myelin Sheath; Phenotype; Receptor, Adenosine A1; Recurrence; RNA, Messenger; Severity of Illness Index; Spinal Cord; Up-Regulation | 2004 |
Evidence for a mitochondrial impact of trimetazidine during cold ischemia and reperfusion.
Topics: Adenosine; Allopurinol; Animals; Biomarkers; Cryopreservation; Disaccharides; Disease Models, Animal; Drug Evaluation, Preclinical; Electrolytes; Glutamates; Glutathione; Histidine; Insulin; Kidney Function Tests; Kidney Transplantation; Mannitol; Mitochondria; Organ Preservation; Organ Preservation Solutions; Raffinose; Receptors, GABA-A; Reperfusion Injury; Swine; Time Factors; Transplantation, Autologous; Trimetazidine | 2004 |
Protection against cisplatin ototoxicity by adenosine agonists.
Topics: Adenosine; Animals; Antineoplastic Agents; Chinchilla; Cisplatin; Cochlea; Disease Models, Animal; Hearing Disorders; Lipid Peroxidation; Male; Neuroprotective Agents; Phenethylamines; Receptors, Purinergic P1 | 2004 |
Effects of adenosine and verapamil on anatomic no-reflow in a rabbit model of coronary artery occlusion and reperfusion.
Topics: Adenosine; Animals; Blood Pressure; Coronary Disease; Coronary Vasospasm; Disease Models, Animal; Male; Myocardial Reperfusion Injury; Rabbits; Verapamil | 2004 |
A2A adenosine receptor activation improves survival in mouse models of endotoxemia and sepsis.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Endotoxemia; Escherichia coli; Escherichia coli Infections; Female; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Purines; Receptors, Adenosine A2; Sepsis; Survival Analysis | 2004 |
Experimental hypothyroidism modifies specific binding of A1 and A2A analogues to adenosine receptors in the rat kidney.
Topics: Adenosine; Animals; Binding Sites; Disease Models, Animal; Hypothyroidism; Kidney; Male; Protein Binding; Radioligand Assay; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptor, Adenosine A2A | 2004 |
Maintenance of glucose-sensitive insulin secretion of cryopreserved human islets with University of Wisconsin solution and ascorbic acid-2 glucoside.
Topics: Adenosine; Allopurinol; Animals; Ascorbic Acid; Cell Survival; Cell Transplantation; Cells, Cultured; Cryopreservation; Disease Models, Animal; DNA; Gene Transfer Techniques; Glutathione; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Nude; Organ Preservation Solutions; Polymerase Chain Reaction; Raffinose; RNA; Sensitivity and Specificity; Tissue Preservation; Transplantation, Heterologous | 2004 |
[Effect of adenosine on activity of transcription factor NF-kappa B and cytokines in myocardial tissue of experimental rats with pneumonia].
Topics: Adenosine; Animals; Anti-Arrhythmia Agents; Cytokines; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Female; Gene Expression; Interleukin-6; Male; Myocardium; NF-kappa B; Pneumonia, Staphylococcal; Random Allocation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha | 2004 |
Adenosine acting via A1 receptors, controls the transition to status epilepticus-like behaviour in an in vitro model of epilepsy.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine Triphosphate; Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Hippocampus; In Vitro Techniques; Rats; Rats, Wistar; Receptor, Adenosine A1; Status Epilepticus; Xanthines | 2004 |
Neuroprotective effect of L-DOPA co-administered with the adenosine A2A receptor agonist CGS 21680 in an animal model of Parkinson's disease.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Analysis of Variance; Animals; Antiparkinson Agents; Apomorphine; Cell Count; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Drug Therapy, Combination; Dyskinesias; Immunohistochemistry; Levodopa; Male; Oxidopamine; Parkinson Disease; Phenethylamines; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Sympatholytics; Time Factors; Tyrosine 3-Monooxygenase | 2004 |
Prevention of postischemic spinal cord injury by means of regional infusion of adenosine and L-carnitine dissolved in normothermic saline.
Topics: Adenosine; Animals; Axons; Blood Pressure; Carnitine; Disease Models, Animal; Female; Infusions, Intra-Arterial; Male; Models, Cardiovascular; Neuroglia; Neuroprotective Agents; Paraplegia; Rabbits; Reperfusion Injury; Sodium Chloride; Spinal Cord Injuries; Spinal Cord Ischemia; Time Factors; Vasodilator Agents | 2004 |
Attenuation of ischemia-reperfusion injury in a canine model of autologous renal transplantation.
Topics: Acetylcysteine; Adenosine; Allopurinol; Aminoimidazole Carboxamide; Animals; Apoptosis; Creatinine; Disease Models, Animal; Dogs; Glutathione; Graft Survival; Immunohistochemistry; Insulin; Kidney; Kidney Transplantation; Male; Nephrectomy; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Organ Preservation; Organ Preservation Solutions; Raffinose; Reperfusion Injury; Ribonucleotides; Transplantation, Autologous; Tumor Necrosis Factor-alpha | 2004 |
Biochemical brain markers and purinergic parameters in rat CSF after seizure induced by pentylenetetrazol.
Topics: Adenosine; Adenosine Diphosphate; Animals; Antigens, CD; Apyrase; Biomarkers; Brain; Convulsants; Disease Models, Animal; Female; Guanosine; Guanosine Diphosphate; Hydrolysis; Inosine; Nerve Degeneration; Nerve Growth Factors; Nerve Tissue Proteins; Pentylenetetrazole; Phosphopyruvate Hydratase; Purines; Rats; Rats, Wistar; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Seizures; Time Factors; Up-Regulation | 2004 |
Intraperitoneal administration of adenosine inhibits formation of abdominal adhesions.
Topics: Adenosine; Animals; Disease Models, Animal; Injections, Intraperitoneal; Intestinal Diseases; Intestinal Obstruction; Male; Postoperative Complications; Rats; Rats, Sprague-Dawley; Tissue Adhesions | 2004 |
Myocardium tolerant to an adenosine-dependent ischemic preconditioning stimulus can still be protected by stimuli that employ alternative signaling pathways.
Topics: Adaptation, Physiological; Adenosine; Animals; Blood Pressure; Disease Models, Animal; Heart Rate; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardium; Rats; Rats, Wistar; Signal Transduction; Vasodilator Agents | 2005 |
Changes in the steady-state potential in rats with focal cerebral ischemia receiving cyclopentyladenosine.
Topics: Action Potentials; Adenosine; Animals; Brain Ischemia; Disease Models, Animal; Female; Infarction, Middle Cerebral Artery; Male; Microelectrodes; Neuroprotective Agents; Parietal Lobe; Rats; Time Factors | 2003 |
Activation of A3 adenosine receptor provides lung protection against ischemia-reperfusion injury associated with reduction in apoptosis.
Topics: Adenosine; Animals; Apoptosis; Cats; Disease Models, Animal; In Situ Nick-End Labeling; Lung; Lung Injury; Receptor, Adenosine A3; Reperfusion Injury | 2004 |
A mouse model of cerebral oligemia: relation to brain histopathology, cerebral blood flow, and energy state.
Topics: Adenosine; Adenosine Triphosphate; Animals; Biomarkers; Brain Ischemia; Carotid Stenosis; Cerebral Cortex; Cerebrovascular Circulation; Disease Models, Animal; Down-Regulation; Energy Metabolism; Female; Mice; Mice, Inbred DBA; Nerve Degeneration; Neurons; Oxidative Phosphorylation; Phosphocreatine; Up-Regulation | 2005 |
Synergistic value of fibrinolysis and hypothermic aerobic preservation with oxygen in the protection of livers from non-heart-beating donors: an experimental model.
Topics: Adenosine; Aerobiosis; Allopurinol; Animals; Bile; Cell Death; Disease Models, Animal; Fibrinolysis; Glutathione; Heart Arrest; Hypothermia; Insulin; Liver; Male; Organ Preservation; Organ Preservation Solutions; Raffinose; Rats; Rats, Wistar; Vascular Resistance | 2004 |
CF101, an agonist to the A3 adenosine receptor, enhances the chemotherapeutic effect of 5-fluorouracil in a colon carcinoma murine model.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Antimetabolites, Antineoplastic; Cell Proliferation; Colonic Neoplasms; Colony-Forming Units Assay; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Humans; Mice; Mice, Inbred BALB C; Transplantation, Heterologous; Tumor Cells, Cultured | 2005 |
[Inoculation of bacille calmette guerin combined with intraperitoneal adenosine injection enhances antibacterial effect of macrophage against Mycobacterium tuberculosis in mice].
Topics: Adenosine; Animals; BCG Vaccine; Disease Models, Animal; Drug Therapy, Combination; Injections, Intradermal; Injections, Intraperitoneal; Macrophages; Mice; Mice, Inbred BALB C; Mycobacterium tuberculosis; Neutrophil Infiltration; Phagocytosis; Tuberculosis, Pulmonary | 2004 |
[Early and late effects of adenosine in experimental ventricular tachycardia].
Topics: Adenosine; Animals; Anti-Arrhythmia Agents; Case-Control Studies; Disease Models, Animal; Dogs; Electrocardiography; Models, Theoretical; Tachycardia, Ventricular; Time Factors; Treatment Outcome | 2005 |
Effect of subchronic caffeine treatment on MK-801-induced changes in locomotion, cognition and ataxia in mice.
Topics: Adenosine; Amphetamine; Animals; Ataxia; Caffeine; Central Nervous System Stimulants; Cognition; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Humans; Locomotion; Male; Mice; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2005 |
Potentiation of neutrophil cyclooxygenase-2 by adenosine: an early anti-inflammatory signal.
Topics: Adenosine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Humans; Inflammation; Injections, Subcutaneous; Leukocytes; Lipopolysaccharides; Membrane Proteins; Mice; Mice, Knockout; Mice, Transgenic; Neutrophils; Prostaglandin-Endoperoxide Synthases; Receptor, Adenosine A2A; Signal Transduction; Time Factors | 2005 |
CGS21680 attenuates symptoms of Huntington's disease in a transgenic mouse model.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Brain; Disease Models, Animal; Huntington Disease; Male; Mice; Mice, Transgenic; Motor Activity; Phenethylamines | 2005 |
Apoptosis inhibition during preservation by fructose-1,6-diphosphate and theophylline in rat intestinal transplantation.
Topics: Adenosine; Adenosine Triphosphate; Animals; Apoptosis; Bacterial Translocation; Disease Models, Animal; Fructosediphosphates; Ischemia; Jejunum; Male; Neutrophil Infiltration; Organ Preservation Solutions; Prospective Studies; Rats; Rats, Wistar; Reference Values; Theophylline | 2005 |
Astrocytes and neurons: different roles in regulating adenosine levels.
Topics: Adenosine; Affinity Labels; Animals; Astrocytes; Brain Ischemia; Cells, Cultured; Deoxyglucose; Dipyridamole; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Glucose; Hypoxia; Inosine; Models, Biological; Neurons; Oligomycins; Phosphodiesterase Inhibitors; Prosencephalon; Purines; Rats; Thioinosine; Tritium | 2005 |
Nitrogen oxide blockade does not aggravate the endothelin-1-induced myocardial ischemia and release of purine metabolites from the dog heart.
Topics: Adaptation, Physiological; Adenosine; Animals; Disease Models, Animal; Dogs; Endothelin-1; Enzyme Inhibitors; Hemodynamics; Hypoxanthine; Inosine; Myocardial Ischemia; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pericardium; Purines | 2004 |
New adenosine A2A receptor antagonists: actions on Parkinson's disease models.
Topics: Adenine; Adenosine; Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Behavior, Animal; Binding, Competitive; Catalepsy; CHO Cells; Cricetinae; Cricetulus; Disease Models, Animal; Drug Synergism; Levodopa; Male; Molecular Structure; Parkinson Disease; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Tritium | 2005 |
[Beneficial effects of adenosine on myocardial no-reflow in a mini-swine model of acute myocardial infarction and reperfusion].
Topics: Adenosine; Animals; Cardiac Output; Coronary Circulation; Disease Models, Animal; Female; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Pulmonary Wedge Pressure; Swine; Swine, Miniature | 2005 |
Effects of adenosine and defibrotide adjunct to a standard crystalloid cardioplegic solution.
Topics: Adenosine; Animals; Cardioplegic Solutions; Coronary Circulation; Disease Models, Animal; Drug Combinations; Fibrinolytic Agents; Heart Arrest, Induced; Heart Rate; In Vitro Techniques; Male; Myocardial Ischemia; Polydeoxyribonucleotides; Rats; Rats, Wistar; Recovery of Function; Vasodilator Agents | 2005 |
Modulation of seizures and synaptic plasticity by adenosinergic receptors in an experimental model of temporal lobe epilepsy induced by pilocarpine in rats.
Topics: 5'-Nucleotidase; Adenosine; Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; In Situ Nick-End Labeling; Male; Neuronal Plasticity; Neuroprotective Agents; Pilocarpine; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Rats, Wistar; Receptors, Purinergic P1; Status Epilepticus; Synapses; Triazoles; Xanthines | 2005 |
The role of adenosine A(1) receptors in the interaction between amygdala and entorhinal cortex of kindled rats.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Amygdala; Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Entorhinal Cortex; Kindling, Neurologic; Male; Microinjections; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Adenosine A1; Seizures; Time Factors; Xanthines | 2005 |
A novel A1 adenosine receptor antagonist, L-97-1 [3-[2-(4-aminophenyl)-ethyl]-8-benzyl-7-{2-ethyl-(2-hydroxy-ethyl)-amino]-ethyl}-1-propyl-3,7-dihydro-purine-2,6-dione], reduces allergic responses to house dust mite in an allergic rabbit model of asthma.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Disease Models, Animal; Dose-Response Relationship, Drug; Dust; Histamine; Mites; Phosphodiesterase Inhibitors; Purines; Rabbits; Radioligand Assay; Receptor, Adenosine A1 | 2005 |
ATP extracellular concentrations are increased in the rat striatum during in vivo ischemia.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Triphosphate; Animals; Brain Infarction; Brain Ischemia; Corpus Striatum; Disease Models, Animal; Enzyme Inhibitors; Extracellular Fluid; Infarction, Middle Cerebral Artery; Male; Microdialysis; Movement Disorders; Rats; Rats, Wistar; Receptors, Purinergic P2; Up-Regulation | 2005 |
Adenosine-dependent pulmonary fibrosis in adenosine deaminase-deficient mice.
Topics: Adenosine; Adenosine Deaminase; Animals; Chronic Disease; Collagen; Disease Models, Animal; Dose-Response Relationship, Immunologic; Drug Administration Schedule; Inflammation Mediators; Lung; Macrophages, Alveolar; Mice; Mice, Inbred C57BL; Mice, Knockout; Pulmonary Fibrosis; Receptors, Purinergic P1 | 2005 |
Increase of adenosine A1 receptor gene expression in cerebral ischemia of Wistar rats.
Topics: Adenosine; Animals; Brain Ischemia; Cerebral Cortex; Cerebral Infarction; Cerebrovascular Circulation; Cytoprotection; Disease Models, Animal; Gene Expression Regulation; Male; Nerve Degeneration; Rats; Rats, Wistar; Receptor, Adenosine A1; Reperfusion Injury; RNA, Messenger; Up-Regulation | 2005 |
Genetically based resistance to the antiinflammatory effects of methotrexate in the air-pouch model of acute inflammation.
Topics: Acute Disease; Adenosine; Air; Animals; Anti-Inflammatory Agents; Carrageenan; Chromosome Mapping; Disease Models, Animal; Drug Resistance; Exudates and Transudates; Inbreeding; Inflammation; Injections, Subcutaneous; Methotrexate; Mice; Mice, Inbred Strains; Osmolar Concentration; Phenotype; Quantitative Trait Loci | 2005 |
The lack of A2A adenosine receptors diminishes the reinforcing efficacy of cocaine.
Topics: Adenosine; Animals; Brain; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Disease Models, Animal; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Female; Infusions, Intravenous; Male; Mice; Mice, Knockout; Motor Activity; Receptor, Adenosine A2A; Reinforcement, Psychology; Reward; Self Administration | 2006 |
Involvement of 5-HT1A receptors in the antidepressant-like effect of adenosine in the mouse forced swimming test.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Antidepressive Agents; Brain; Depressive Disorder; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Female; Male; Mice; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Serotonin, 5-HT1A; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Stress, Psychological; Swimming; Synaptic Transmission | 2005 |
Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats.
Topics: Adenosine; Animals; Caffeine; Coffea; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking Behavior; Epilepsy, Temporal Lobe; Kainic Acid; Male; Pilocarpine; Rats; Rats, Wistar; Seizures; Status Epilepticus; Substance Withdrawal Syndrome | 2005 |
Use and limitations of magnetic resonance phase-contrast assessment of coronary flow reserve in a model of collateral dependence.
Topics: Adenosine; Animals; Blood Flow Velocity; Caseins; Collateral Circulation; Constriction, Pathologic; Coronary Circulation; Coronary Stenosis; Coronary Vessels; Disease Models, Animal; Hydrogels; Hyperemia; Magnetic Resonance Angiography; Myocardium; Regional Blood Flow; Sus scrofa | 2005 |
Evaluation of interaction between intrathecal adenosine and MK801 or NBQX in a rat formalin pain model.
Topics: Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Disease Models, Animal; Dizocilpine Maleate; Drug Synergism; Excitatory Amino Acid Antagonists; Formaldehyde; Injections, Spinal; Male; N-Methylaspartate; Pain; Quinoxalines; Rats; Rats, Sprague-Dawley | 2005 |
Inflammatory responses in a new mouse model of prolonged hepatic cold ischemia followed by arterialized orthotopic liver transplantation.
Topics: Adenosine; Allopurinol; Animals; Apoptosis; CD4 Lymphocyte Count; Disease Models, Animal; Glutathione; Immunohistochemistry; Inflammation; Insulin; Ischemia; Liver; Liver Transplantation; Male; Mice; Mice, Inbred BALB C; Organ Preservation Solutions; Postoperative Complications; Raffinose; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes; Treatment Outcome | 2005 |
Complement activation-related cardiac anaphylaxis in pigs: role of C5a anaphylatoxin and adenosine in liposome-induced abnormalities in ECG and heart function.
Topics: Adenosine; Anaphylaxis; Animals; Arrhythmias, Cardiac; Complement Activation; Disease Models, Animal; Electrocardiography; Liposomes; Receptor, Anaphylatoxin C5a; Receptors, Purinergic P1; Swine; Ventricular Dysfunction, Left | 2006 |
Role of adenosine in airway inflammation in an allergic mouse model of asthma.
Topics: Adenosine; Animals; Asthma; beta-N-Acetylhexosaminidases; Bronchoalveolar Lavage Fluid; Chemokine CCL11; Chemokines, CC; Disease Models, Animal; Eosinophil Peroxidase; Immunization; Inflammation; Inflammation Mediators; Male; Mast Cells; Mice; Mice, Inbred BALB C; Neutrophils; Peroxidase; Pollen; Respiratory System | 2006 |
mRNA expression in mouse hypothalamus and basal forebrain during influenza infection: a novel model for sleep regulation.
Topics: Acute-Phase Proteins; Adenosine; Animals; Disease Models, Animal; Hypothalamus; Intramolecular Oxidoreductases; Lipocalin-2; Lipocalins; Male; Methyltransferases; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Models, Biological; Oncogene Proteins; Orthomyxoviridae Infections; Prosencephalon; Receptors, Corticotropin-Releasing Hormone; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sleep | 2006 |
Activation of adenosine A1 receptors reduces anxiety-like behavior during acute ethanol withdrawal (hangover) in mice.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Alcoholic Intoxication; Analysis of Variance; Animals; Anxiety; Central Nervous System Depressants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Exploratory Behavior; Male; Maze Learning; Mice; Receptor, Adenosine A1; Time Factors | 2006 |
Adenosine treatment delays postischemic hippocampal CA1 loss after cardiac arrest and resuscitation in rats.
Topics: Adenosine; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Body Temperature; Brain Edema; Brain Ischemia; Cell Count; Cell Death; Disease Models, Animal; Heart Arrest; Hippocampus; Male; Neurons; Physical Examination; Rats; Rats, Wistar; Recovery of Function; Regional Blood Flow; Reperfusion; Resuscitation; Time Factors; Water | 2006 |
A2a receptors mediate inhibitory effects of adenosine on colonic motility in the presence of experimental colitis.
Topics: Adenosine; Animals; Colitis; Disease Models, Animal; Gastrointestinal Motility; Intestinal Mucosa; Male; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Reverse Transcriptase Polymerase Chain Reaction; Sensitivity and Specificity; Tissue Culture Techniques; Triazines; Triazoles | 2006 |
Hypoxia-induced desensitization and internalization of adenosine A1 receptors in the rat hippocampus.
Topics: 2-Chloroadenosine; Adenosine; Adenosine A1 Receptor Antagonists; Animals; Disease Models, Animal; Endocytosis; Excitatory Postsynaptic Potentials; Hippocampus; Hypoxia-Ischemia, Brain; Male; Neural Inhibition; Presynaptic Terminals; Rats; Rats, Wistar; Receptor, Adenosine A1; Synaptic Transmission; Theophylline; Xanthines | 2006 |
Effects of perfusion solutions on kidney ischemia-reperfusion injury in pigs.
Topics: Adenosine; Allopurinol; Animals; Disease Models, Animal; Glutathione; Glutathione Peroxidase; Insulin; Isotonic Solutions; Kidney Transplantation; Male; Malondialdehyde; Organ Preservation Solutions; Perfusion; Raffinose; Renal Circulation; Reperfusion Injury; Ringer's Lactate; Solutions; Swine; Thiobarbituric Acid Reactive Substances | 2006 |
[Effect of adenosine on endothelin-1 in the infarcted reflow and no-reflow myocardium of mini-swine].
Topics: Adenosine; Animals; Disease Models, Animal; Endothelin-1; Female; Male; Myocardial Infarction; Myocardial Reperfusion; Swine; Swine, Miniature | 2006 |
Experimental studies and theoretical aspects on A2A/D2 receptor interactions in a model of Parkinson's disease. Relevance for L-dopa induced dyskinesias.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Adrenergic Agents; Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Interactions; Electrochemistry; gamma-Aminobutyric Acid; Globus Pallidus; Male; Microdialysis; Models, Biological; Oxidopamine; Parkinson Disease; Phenethylamines; Quinpirole; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Dopamine D2 | 2006 |
Adenosine is upregulated during peritonitis and is involved in downregulation of inflammation.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Antihypertensive Agents; Cells, Cultured; Disease Models, Animal; Down-Regulation; Epithelium; Escherichia coli; Female; Humans; Inflammation; Interleukin-6; Leukocytes; Mice; Mice, Inbred Strains; Peritonitis; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptors, Purinergic P1; RNA, Messenger; Theobromine; Tumor Necrosis Factor-alpha; Up-Regulation; Xanthines | 2006 |
The effect of an adenosine A1 receptor agonist in the treatment of experimental subarachnoid hemorrhage-induced cerebrovasospasm.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Cerebral Arteries; Disease Models, Animal; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Subarachnoid Hemorrhage; Treatment Outcome; Vasodilation; Vasodilator Agents; Vasospasm, Intracranial | 2006 |
Study of the adenosinergic system in the brain of HPRT knockout mouse (Lesch-Nyhan disease).
Topics: Adenosine; Animals; Brain; Disease Models, Animal; Gene Expression Profiling; Hypoxanthine Phosphoribosyltransferase; Lesch-Nyhan Syndrome; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, Adenosine A1; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2006 |
Calcitonin gene-related peptide and substance P regulate the intestinal radiation response.
Topics: Adenosine; Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Disease Models, Animal; Gene Expression Profiling; Intestines; Male; Multivariate Analysis; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Radiation Injuries, Experimental; Rats; Rats, Sprague-Dawley; Receptors, Calcitonin Gene-Related Peptide; Receptors, Neurokinin-1; Reverse Transcriptase Polymerase Chain Reaction; Substance P; X-Rays | 2006 |
Ex vivo application of carbon monoxide in University of Wisconsin solution to prevent intestinal cold ischemia/reperfusion injury.
Topics: Adenosine; Allopurinol; Animals; Antimetabolites; Carbon Monoxide; Disease Models, Animal; Glutathione; Graft Survival; Insulin; Intestinal Mucosa; Intestine, Small; Male; Microscopy, Electron, Transmission; Organ Preservation; Organ Preservation Solutions; Organ Transplantation; Raffinose; Rats; Rats, Inbred Lew; Reperfusion Injury; Treatment Outcome | 2006 |
Lack of flow-mediated dilation and enhanced angiotensin II-induced constriction in skeletal muscle arterioles of lupus-prone autoimmune mice.
Topics: Acetylcholine; Adenosine; Angiotensin II; Animals; Antibodies, Antinuclear; Arterioles; Blood Pressure; Bradykinin; Disease Models, Animal; Endothelium, Vascular; Female; Hemorheology; Lupus Erythematosus, Systemic; Mice; Mice, Inbred MRL lpr; Muscle, Skeletal; Nitroprusside; Serotonin; Vasoconstriction; Vasodilation; Vasodilator Agents | 2006 |
Beta-amyloid treatment sensitizes mice to amphetamine-induced locomotion but reduces response to caffeine.
Topics: Adenosine; Adrenergic Agents; Alzheimer Disease; Amphetamine; Amyloid beta-Peptides; Animals; Avoidance Learning; Brain; Caffeine; Central Nervous System Stimulants; Disease Models, Animal; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Antagonists; Glutamine; Injections, Intraventricular; Male; Mice; Motor Activity; Psychotic Disorders | 2004 |
ADOA3R as a therapeutic target in experimental colitis: proof by validated high-density oligonucleotide microarray analysis.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Colitis; Disease Models, Animal; Free Radicals; Gene Expression Regulation; Glutathione Peroxidase; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Trinitrobenzenesulfonic Acid | 2006 |
Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain beta-amyloid production.
Topics: Adenosine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Brain; Caffeine; Cell Line, Tumor; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Memory Disorders; Memory, Short-Term; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroprotective Agents; Neuropsychological Tests; Peptide Fragments; Presenilin-1; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Treatment Outcome | 2006 |
The characteristics of intravenous adenosine-induced antinociception in a rabbit model of acute nociceptive pain: a comparative study with remifentanil.
Topics: Adenosine; Analgesics; Analgesics, Opioid; Anesthetics, Inhalation; Animals; Blood Pressure; Carbon Dioxide; Disease Models, Animal; Heart Rate; Infusions, Intravenous; Isoflurane; Male; Nociceptors; Pain; Pain Measurement; Piperidines; Rabbits; Remifentanil; Respiration | 2006 |
Evidence for adenosine- and serotonin-mediated antihyperalgesic effects of cizolirtine in rats suffering from diabetic neuropathy.
Topics: Adenosine; Analgesics; Animals; Area Under Curve; Caffeine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Hyperalgesia; Male; Oxadiazoles; Pain Measurement; Pain Threshold; Piperazines; Psychomotor Performance; Pyrazoles; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Vocalization, Animal | 2007 |
Protective effects of caffeine on chronic hypoxia-induced perinatal white matter injury.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Animals, Newborn; Asphyxia Neonatorum; Brain; Caffeine; Cell Differentiation; Cell Lineage; Chronic Disease; Disease Models, Animal; Female; Humans; Hypoxia, Brain; Infant, Newborn; Leukomalacia, Periventricular; Mice; Mice, Inbred C57BL; Nerve Fibers, Myelinated; Neuroprotective Agents; Oligodendroglia; Pregnancy; Receptor, Adenosine A1; Stem Cells | 2006 |
Involvement of adenosinergic receptor system in an animal model of tardive dyskinesia and associated behavioural, biochemical and neurochemical changes.
Topics: Adenosine; Akathisia, Drug-Induced; Animals; Antioxidants; Behavior, Animal; Brain; Caffeine; Catalase; Central Nervous System Stimulants; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; Haloperidol; Lipid Peroxidation; Male; Mastication; Maze Learning; Motor Activity; Neurotransmitter Agents; Rats; Rats, Wistar; Receptors, Purinergic P1; Stereotyped Behavior; Superoxide Dismutase; Vasodilator Agents | 2006 |
Adenosine A1 and A2 receptor agonists reduce endotoxin-induced cellular energy depletion and oedema formation in the lung.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Adenosine Diphosphate; Adenosine Triphosphate; Analysis of Variance; Animals; Blood Pressure; Chromatography, High Pressure Liquid; Disease Models, Animal; Endotoxemia; Endotoxins; Energy Metabolism; Female; Lipopolysaccharides; Lung; Pulmonary Artery; Pulmonary Edema; Rabbits; Receptors, Purinergic P1; Respiratory Distress Syndrome; Time Factors; Uric Acid; Vasoconstriction | 2007 |
Anticonvulsant effects of focal and intracerebroventricular adenosine on penicillin-induced epileptiform activity in rats.
Topics: Action Potentials; Adenosine; Animals; Anticonvulsants; Brain; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Electroencephalography; Epilepsy; Female; Injections, Intraventricular; Penicillins; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Theophylline | 2007 |
Co-modulation of acute ethanol-induced motor impairment by mouse cerebellar adenosinergic A1 and GABA(A) receptor systems.
Topics: Acute Disease; Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Alcohol-Induced Disorders, Nervous System; Animals; Central Nervous System Depressants; Cerebellar Ataxia; Cerebellum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred ICR; Presynaptic Terminals; Receptor, Adenosine A1; Receptors, GABA-A; Synaptic Transmission; Xanthines | 2006 |
Postischemic augmentation of conducted dilation in cerebral arterioles.
Topics: Adenosine; Adenosine Triphosphate; Animals; Arterioles; Brain Ischemia; Cerebral Arteries; Cerebrovascular Circulation; Disease Models, Animal; Infarction, Middle Cerebral Artery; Male; Microcirculation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Tetrazolium Salts; Vasoconstriction; Vasodilation; Vasomotor System | 2007 |
Anticonvulsant effects of N6-cyclohexyladenosine microinjected into the CA1 region of the hippocampus on entorhinal cortex-kindled seizures in rats.
Topics: Adenosine; Animals; Anticonvulsants; Disease Models, Animal; Hippocampus; Kindling, Neurologic; Male; Microinjections; Pyramidal Cells; Rats; Rats, Sprague-Dawley | 2006 |
Effect of a specific and selective A(2B) adenosine receptor antagonist on adenosine agonist AMP and allergen-induced airway responsiveness and cellular influx in a mouse model of asthma.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Adenosine Monophosphate; Adenosine-5'-(N-ethylcarboxamide); Administration, Inhalation; Aerosols; Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchodilator Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Mice; Mice, Inbred Strains; Plethysmography; Purines; Pyrazoles | 2007 |
Organ biodistribution and myocardial uptake, washout, and redistribution kinetics of Tc-99m N-DBODC5 when injected during vasodilator stress in canine models of coronary stenoses.
Topics: Adenosine; Animals; Coronary Stenosis; Disease Models, Animal; Dogs; Injections; Injections, Intra-Arterial; Metabolic Clearance Rate; Myocardium; Organ Specificity; Organophosphorus Compounds; Organotechnetium Compounds; Radionuclide Imaging; Radiopharmaceuticals; Tissue Distribution; Vasodilator Agents; Ventricular Dysfunction, Left | 2006 |
Usage of the T1 effect of an iron oxide contrast agent in an animal model to quantify myocardial blood flow by MRI.
Topics: Adenosine; Analysis of Variance; Animals; Balloon Occlusion; Blood Flow Velocity; Contrast Media; Coronary Circulation; Coronary Stenosis; Disease Models, Animal; Ferric Compounds; Heart Ventricles; Image Enhancement; Linear Models; Magnetic Resonance Imaging; Microspheres; Myocardium; Research Design; Swine; Time Factors; Vasodilation; Vasodilator Agents | 2007 |
The novel adenosine A2a antagonist ST1535 potentiates the effects of a threshold dose of l-dopa in unilaterally 6-OHDA-lesioned rats.
Topics: Adenine; Adenosine; Adenosine A2 Receptor Antagonists; Animals; Brain; Disease Models, Animal; Dopamine Agents; Dose-Response Relationship, Drug; Drug Synergism; Exploratory Behavior; Levodopa; Male; Movement; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Receptor, Adenosine A2A; Sympatholytics; Triazoles | 2007 |
Protective role of ecto-5'-nucleotidase (CD73) in renal ischemia.
Topics: 5'-Nucleotidase; Acute Kidney Injury; Adenosine; Animals; Disease Models, Animal; Ischemia; Ischemic Preconditioning; Kidney; Mice; Mice, Inbred C57BL; Mice, Knockout | 2007 |
The impact of adenosine and A(2B) receptors on glucose homoeostasis.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Analysis of Variance; Animals; Antineoplastic Agents; Blood Glucose; Cell Line, Tumor; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Homeostasis; Insulin; Male; Phenethylamines; Radioimmunoassay; Rats; Rats, Wistar; Receptor, Adenosine A2B; Sulfonic Acids; Xanthines | 2006 |
Opposite effects of the A2A receptor agonist CGS21680 in the striatum of Huntington's disease versus wild-type mice.
Topics: Action Potentials; Adenosine; Adenosine A2 Receptor Agonists; Animals; Antihypertensive Agents; Corpus Striatum; Disease Models, Animal; Huntington Disease; Mice; Mice, Transgenic; Neuroprotective Agents; Neurotoxins; Organ Culture Techniques; Phenethylamines; Receptor, Adenosine A2A; Receptors, N-Methyl-D-Aspartate; Recovery of Function; Species Specificity; Synaptic Transmission | 2007 |
The role of adenosine A2a receptors in experimental acute pancreatitis.
Topics: Acute Disease; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Amylases; Animals; Disease Models, Animal; Immunohistochemistry; Lipase; Male; Pancreas; Pancreatitis; Phenethylamines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Taurocholic Acid; Triazines; Triazoles | 2006 |
Attenuation of experimental subarachnoid hemorrhage--induced cerebral vasospasm by the adenosine A2A receptor agonist CGS 21680.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Antihypertensive Agents; Disease Models, Animal; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Phenethylamines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Subarachnoid Hemorrhage; Vasospasm, Intracranial | 2007 |
A1 adenosine receptor upregulation accompanies decreasing myocardial adenosine levels in mice with left ventricular dysfunction.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Disease Models, Animal; Female; Heart Failure; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Myocardium; Receptor, Adenosine A1; Receptor, Adenosine A2A; Signal Transduction; Tumor Necrosis Factor-alpha; Up-Regulation; Ventricular Dysfunction, Left | 2007 |
Sleep fragmentation elevates behavioral, electrographic and neurochemical measures of sleepiness.
Topics: Adenosine; Analysis of Variance; Animals; Behavior, Animal; Brain Chemistry; Circadian Rhythm; Disease Models, Animal; Electroencephalography; Exercise Test; Male; Microdialysis; Motor Activity; Polysomnography; Prosencephalon; Rats; Rats, Sprague-Dawley; Sleep Deprivation; Sleep Stages; Time Factors; Wakefulness | 2007 |
Antinociceptive interactions of triple and quadruple combinations of endogenous ligands at the spinal level.
Topics: Adenosine; Agmatine; Analgesics; Animals; Area Under Curve; Disease Models, Animal; Drug Combinations; Injections, Spinal; Kynurenic Acid; Ligands; Male; Motor Activity; Oligopeptides; Pain; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Opioid, mu; Spinal Cord | 2007 |
Inhibition of p38 MAPK and AMPK restores adenosine-induced cardioprotection in hearts stressed by antecedent ischemia by altering glucose utilization.
Topics: Adenosine; AMP-Activated Protein Kinases; Animals; Cardiotonic Agents; Disease Models, Animal; Glucose; Glycogen; Glycolysis; Hydrogen-Ion Concentration; Imidazoles; In Vitro Techniques; Male; Multienzyme Complexes; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Ventricular Function, Left | 2007 |
Delayed 24 hours Nomega-nitro-L-arginine methyl ester injection induces pharmacological cardioprotection against reperfusion injury.
Topics: Adenosine; Animals; Arginine; Blood Pressure; Cardiotonic Agents; Disease Models, Animal; Enzyme Inhibitors; Myocardial Ischemia; Myocardial Reperfusion Injury; Nitrates; Nitric Oxide Synthase; Nitrites; Perfusion; Rats; Regional Blood Flow; Theophylline; Time Factors; Troponin I; Ventricular Function, Left | 2007 |
The role of adenosine A1 and A2A receptors of entorhinal cortex on piriform cortex kindled seizures in rats.
Topics: Adenosine; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Entorhinal Cortex; Kindling, Neurologic; Male; Microinjections; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Seizures; Triazines; Triazoles; Xanthines | 2007 |
Adenosine deaminase inhibition enhances the inotropic response mediated by A1 adenosine receptor in hyperthyroid guinea pig atrium.
Topics: Adenine; Adenosine; Adenosine A1 Receptor Agonists; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Benzyl Compounds; Cyclic Nucleotide Phosphodiesterases, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Heart Atria; Hyperthyroidism; Inosine; Male; Myocardial Contraction; Pentostatin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Receptor, Adenosine A1; Signal Transduction; Thyroxine | 2007 |
Fetal alcohol exposure alters cerebrovascular reactivity to vasoactive intestinal peptide in adult sheep.
Topics: Adenosine; Animals; Animals, Newborn; Arterioles; Brain; Cerebrovascular Circulation; Disease Models, Animal; Ethanol; Female; Fetal Alcohol Spectrum Disorders; In Vitro Techniques; Male; Phenethylamines; Pregnancy; Prenatal Exposure Delayed Effects; Purinergic P1 Receptor Agonists; Sheep; Vasoactive Intestinal Peptide; Vasodilation; Vasodilator Agents | 2008 |
Activation of central adenosine A(2A) receptors enhances superior laryngeal nerve stimulation-induced apnea in piglets via a GABAergic pathway.
Topics: Adenosine; Animals; Animals, Newborn; Apnea; Bicuculline; Blood Pressure; Cisterna Magna; Disease Models, Animal; Drug Antagonism; Electric Stimulation; GABA Antagonists; gamma-Aminobutyric Acid; Heart Rate; Injections, Intraventricular; Laryngeal Nerves; Phenethylamines; Phrenic Nerve; Receptor, Adenosine A2A; Swine | 2007 |
Targeted deletion of A2A adenosine receptors attenuates the protective effects of myocardial postconditioning.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Disease Models, Animal; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardial Reperfusion Injury; Myocardium; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptor, Adenosine A2A; Research Design; Signal Transduction; Time Factors; Triazines; Triazoles; Troponin I; Ventricular Function, Left; Ventricular Pressure | 2007 |
Long-term administration of 3-deazaadenosine does not alter progression of advanced atherosclerotic lesions in apolipoprotein E-deficient mice.
Topics: Actins; Adenosine; Animals; Aorta, Thoracic; Apolipoproteins E; Atherosclerosis; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Female; Homocysteine; Intercellular Adhesion Molecule-1; Interleukin-10; Interleukin-1beta; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Transcription Factor AP-1; Tubercidin; Vascular Cell Adhesion Molecule-1 | 2007 |
Effect of systemic administration of adenosine on brain adenosine levels in pentylenetetrazol-induced seizure threshold in mice.
Topics: Adenosine; Analysis of Variance; Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Male; Mice; Pentylenetetrazole; Seizures; Time Factors; Vasodilator Agents | 2007 |
CD39/ectonucleoside triphosphate diphosphohydrolase 1 provides myocardial protection during cardiac ischemia/reperfusion injury.
Topics: Adenosine; Adenosine Monophosphate; Animals; Antigens, CD; Apyrase; Disease Models, Animal; Enzyme Induction; Ischemic Preconditioning, Myocardial; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium | 2007 |
Protective roles of adenosine A1, A2A, and A3 receptors in skeletal muscle ischemia and reperfusion injury.
Topics: Adenosine; Animals; Dihydropyridines; Disease Models, Animal; Hindlimb; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; Phenethylamines; Phospholipase C beta; Pyrazoles; Pyrimidines; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Adenosine A3; Reperfusion Injury; Signal Transduction; Xanthines | 2007 |
Ozone oxidative preconditioning is mediated by A1 adenosine receptors in a rat model of liver ischemia/ reperfusion.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Biomarkers; Disease Models, Animal; HSP72 Heat-Shock Proteins; Immunohistochemistry; Ischemic Preconditioning; Liver; Liver Transplantation; Male; NF-kappa B; Nitric Oxide; Oxidants, Photochemical; Oxidative Stress; Ozone; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A1; Reperfusion Injury; Treatment Outcome; Tumor Necrosis Factor-alpha; Xanthines | 2008 |
Effects of ischemic preconditioning and adenosine pretreatment on myocardial function and energetics in a clinically relevant model.
Topics: Adenosine; Animals; Disease Models, Animal; Dogs; Infusions, Intra-Arterial; Ischemic Preconditioning, Myocardial; Myocardial Stunning; Myocardium; Oxygen Consumption; Vasodilator Agents; Ventricular Function, Left | 2007 |
Renal interstitial adenosine is increased in angiotensin II-induced hypertensive rats.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Deaminase; Angiotensin II; Animals; Blood Pressure; Disease Models, Animal; Hypertension; Kidney Cortex; Male; Proteinuria; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; RNA, Messenger; Vasoconstrictor Agents | 2008 |
Regulation of A(2A) adenosine receptor expression and functioning following permanent focal ischemia in rat brain.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Astrocytes; Behavior, Animal; Brain; Brain Ischemia; Disease Models, Animal; Gene Expression Regulation; Guanosine 5'-O-(3-Thiotriphosphate); Male; Motor Activity; Neurologic Examination; Phenethylamines; Rats; Rats, Wistar; Receptors, Adenosine A2 | 2008 |
The neurovascular dysfunction induced by angiotensin II in the mouse neocortex is sexually dimorphic.
Topics: Acetylcholine; Adenosine; Angiotensin II; Animals; Blood Flow Velocity; Blood Pressure; Cerebrovascular Circulation; Disease Models, Animal; Disease Susceptibility; Estradiol; Estrogen Replacement Therapy; Female; Hypertension; Infusion Pumps, Implantable; Laser-Doppler Flowmetry; Male; Mice; Mice, Inbred C57BL; Neocortex; Ovariectomy; Reflex; Sex Factors; Stroke; Time Factors; Vasodilator Agents; Vibrissae | 2008 |
Rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor increases pentylenetetrazol seizure threshold in mice: possible involvement of adenosinergic mechanism.
Topics: Adenine; Adenosine; Analysis of Variance; Animals; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Lactones; Male; Mice; Pentylenetetrazole; Seizures; Sulfones | 2008 |
Synergistic myoprotection of L-arginine and adenosine in a canine model of global myocardial ischaemic reperfusion injury.
Topics: Adenosine; Adenosine Triphosphate; Animals; Arginine; Cardiotonic Agents; Disease Models, Animal; Dogs; Drug Synergism; Energy Metabolism; Female; Heart Arrest, Induced; Male; Myocardial Reperfusion Injury; Myocardium; Peroxidase | 2007 |
Adenosine A1 but not A2a receptor agonist reduces hyperalgesia caused by a surgical incision in rats: a pertussis toxin-sensitive G protein-dependent process.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Disease Models, Animal; Dose-Response Relationship, Drug; GTP-Binding Proteins; Hyperalgesia; Male; Pain, Postoperative; Pertussis Toxin; Phenylisopropyladenosine; Physical Stimulation; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Surgical Procedures, Operative; Vasodilator Agents | 2007 |
Inhibition of protein kinase C alpha improves myocardial beta-adrenergic receptor signaling and ventricular function in a model of myocardial preservation.
Topics: Adenosine; Allopurinol; Animals; Cardioplegic Solutions; Cardiotonic Agents; Disease Models, Animal; Glutathione; Heart Arrest, Induced; Heart Ventricles; In Vitro Techniques; Insulin; Male; Mice; Mice, Transgenic; Myocardial Reperfusion Injury; Myocardium; Organ Preservation; Organ Preservation Solutions; Perfusion; Protein Kinase C-alpha; Raffinose; Receptors, Adrenergic, beta; Recovery of Function; Signal Transduction | 2008 |
Adenosine actions are preserved in corpus cavernosum from obese and type II diabetic db/db mouse.
Topics: Acetylcholine; Adenosine; Adenosine Kinase; Animals; Diabetes Mellitus, Type 2; Dipyridamole; Disease Models, Animal; Electric Stimulation; Enzyme Inhibitors; Male; Mice; Mice, Mutant Strains; Mice, Obese; Muscle Contraction; Muscle, Smooth; Nitroprusside; Penis; Phenylephrine; Phosphodiesterase Inhibitors; Tubercidin; Vasoconstrictor Agents; Vasodilator Agents | 2008 |
Ecto-5'-nucleotidase (CD73) -mediated extracellular adenosine production plays a critical role in hepatic fibrosis.
Topics: 5'-Nucleotidase; Adenosine; Animals; Carbon Tetrachloride; Disease Models, Animal; Extracellular Space; Liver Cirrhosis; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Purinergic P1; Reference Values | 2008 |
HIF-1-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak.
Topics: Adenosine; Adenosine Kinase; Animals; Caco-2 Cells; Capillary Permeability; Colon; Disease Models, Animal; Endothelial Cells; Extravascular Lung Water; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney; Lung; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; RNA, Small Interfering; Signal Transduction; Umbilical Veins | 2008 |
Adenosine-mediated alteration of vascular reactivity and inflammation in a murine model of asthma.
Topics: Acetylcholine; Adenosine; Administration, Inhalation; Allergens; Ambrosia; Animals; Aorta; Asthma; Disease Models, Animal; Dose-Response Relationship, Drug; Flavins; Inflammation; Inflammation Mediators; Lung; Male; Mice; Mice, Inbred BALB C; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Plant Proteins; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Vasodilation; Vasodilator Agents; Xanthines | 2008 |
Effect of hypothyroidism on the purinergic responses of corpus cavernosal smooth muscle in rabbits.
Topics: Adenosine; Adenosine Triphosphate; Analysis of Variance; Animals; Cyclic GMP; Disease Models, Animal; Electric Stimulation; Female; Hypothyroidism; Impotence, Vasculogenic; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Penis; Receptors, Purinergic; Testosterone; Thyroid Hormones; Thyroidectomy | 2008 |
Nitric oxide deficiency and increased adenosine response of afferent arterioles in hydronephrotic mice with hypertension.
Topics: Adenosine; Angiotensin II; Animals; Arterioles; Disease Models, Animal; Enzyme Inhibitors; Hydronephrosis; Hypertension; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Superoxide Dismutase; Superoxide Dismutase-1; Transforming Growth Factors; Vasoconstriction; Vasoconstrictor Agents | 2008 |
Ultrasonic microbubble destruction stimulates therapeutic arteriogenesis via the CD18-dependent recruitment of bone marrow-derived cells.
Topics: Adenosine; Animals; Arterial Occlusive Diseases; Arteries; Bone Marrow Cells; CD18 Antigens; Chimera; Disease Models, Animal; Hindlimb; Hyperemia; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microbubbles; Muscle, Skeletal; Neovascularization, Physiologic; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Ultrasonics | 2008 |
[Different effects of adenosine A2A receptors in the models of traumatic brain injury and peripheral tissue injury].
Topics: Adenosine; Animals; Brain; Brain Injuries; Disease Models, Animal; Glutamic Acid; Mice; Mice, Knockout; Phenethylamines; Receptor, Adenosine A2A; Wound Healing | 2008 |
Pancreatic islet isolation variables in non-human primates (rhesus macaques).
Topics: Adenosine; Allopurinol; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Glutathione; Insulin; Islets of Langerhans; Islets of Langerhans Transplantation; Macaca mulatta; Male; Organ Culture Techniques; Organ Preservation; Organ Preservation Solutions; Raffinose | 2008 |
Reduction of postischemic myocardial dysfunction by substrate repletion during reperfusion.
Topics: Adenosine; Adenosine Triphosphate; Animals; Coronary Disease; Disease Models, Animal; Dogs; Female; Glutamates; Heart; Heart Arrest, Induced; Heart Ventricles; Male; Myocardium; Perfusion; Ribose; Time Factors | 1984 |
Estimation of instantaneous blood flow through a rigid, coronary artery stenosis in anaesthetised domestic swine.
Topics: Adenosine; Animals; Blood Pressure; Coronary Circulation; Coronary Disease; Disease Models, Animal; Models, Cardiovascular; Swine | 1983 |
[The system of active transport of organic acids in the proximal tubules of rats with hereditary retinal degeneration (Campbell strain)].
Topics: Adenosine; Adenosine Monophosphate; Animals; Bile Acids and Salts; Biological Transport, Active; Disease Models, Animal; Fluoresceins; Hippurates; Kidney Tubules, Proximal; Male; Nephrectomy; Rats; Rats, Inbred Strains; Rats, Mutant Strains; Retinitis Pigmentosa; Uric Acid | 1983 |
Animal model for immune dysfunction associated with adenosine deaminase deficiency.
Topics: Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Antibody Formation; B-Lymphocytes; Coformycin; Disease Models, Animal; Immunity, Cellular; Immunologic Deficiency Syndromes; Mice; Nucleoside Deaminases; Pentostatin; Ribonucleosides; T-Lymphocytes | 1980 |
Cold blood-diltiazem cardioplegia.
Topics: Adenosine; Animals; Benzazepines; Biopsy; Blood Transfusion; Diltiazem; Disease Models, Animal; Dogs; Heart Arrest, Induced; Hemodynamics; Myocardium; Phosphates; Phosphocreatine | 1982 |
Electroshock seizures in mice: effect on brain adenosine and its metabolites.
Topics: Adenosine; Animals; Brain; Disease Models, Animal; Electric Stimulation; Hypoxanthines; Inosine; Mice; Seizures | 1981 |
Evaluation of drug effects in a new experimental model of angina pectoris in the intact anesthetized rat.
Topics: Acetylcholine; Adenosine; Anesthesia; Angina Pectoris; Animals; Coronary Vessels; Diltiazem; Dipyridamole; Disease Models, Animal; Electrocardiography; In Vitro Techniques; Male; Methacholine Compounds; Rats; Rats, Inbred Strains; Serotonin | 1981 |
Reduction in cerebral ischemic injury in the newborn rat by potentiation of endogenous adenosine.
Topics: Adenosine; Animals; Animals, Newborn; Body Temperature; Brain; Brain Ischemia; Disease Models, Animal; Dizocilpine Maleate; Enzyme Inhibitors; Neuroprotective Agents; Organ Size; Pentostatin; Rats; Rats, Sprague-Dawley; Xanthines | 1995 |
Changes in sympathetic neurotransmission and adrenergic control of cardiac contractility during 1,3-dipropyl-8-sulfophenylxanthine-induced hypertension.
Topics: Adenosine; Adrenergic beta-Agonists; Animals; Calcium; Cardiotonic Agents; Depression, Chemical; Disease Models, Animal; Heart; Hypertension; In Vitro Techniques; Isoproterenol; Myocardial Contraction; Norepinephrine; Phenylephrine; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Sympathetic Nervous System; Synaptic Transmission; Xanthines | 1995 |
Hyperthyroidism increases adenosine transport and metabolism in the rat heart.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Kinase; Adenosylhomocysteinase; AMP Deaminase; Animals; Biological Transport; Body Weight; Disease Models, Animal; Heart; Hydrolases; Hyperthyroidism; Male; Myocardium; Nucleotidases; Organ Size; Phosphorylation; Purine-Nucleoside Phosphorylase; Rats; Thyroxine; Time Factors; Xanthine Oxidase | 1995 |
Acadesine extends the window of protection afforded by ischaemic preconditioning in conscious rabbits.
Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Disease Models, Animal; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Rabbits; Ribonucleosides; Time Factors; Ventricular Fibrillation | 1995 |
The hypotensive effect of an oral adenosine analog with selectivity for the A2 receptor in the spontaneously hypertensive rat.
Topics: Adenosine; Administration, Oral; Animals; Blood Pressure; Disease Models, Animal; Heart Rate; Hypertension; Kidney; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptors, Purinergic P1 | 1995 |
Digoxin-induced ventricular arrhythmias in the guinea pig heart in vivo: evidence for a role of endogenous catecholamines in the genesis of delayed afterdepolarizations and triggered activity.
Topics: Adenosine; Analysis of Variance; Animals; Arrhythmias, Cardiac; Catecholamines; Digoxin; Disease Models, Animal; Electrocardiography; Female; Guinea Pigs; Male; Propranolol; Random Allocation; Reserpine; Ventricular Dysfunction; Verapamil | 1995 |
Adenosine infusion: a rational approach towards induced hypotension.
Topics: Adenosine; Anesthesia, Inhalation; Animals; Blood Pressure; Cardiac Catheterization; Catheters, Indwelling; Disease Models, Animal; Dose-Response Relationship, Drug; Heart Rate; Hypotension, Controlled; Preanesthetic Medication; Swine; Wakefulness | 1995 |
Adenosine, added to St Thomas' Hospital cardioplegic solution, improves functional recovery and reduces irreversible myocardial damage.
Topics: Adenine Nucleotides; Adenosine; Animals; Cardiac Output; Cardioplegic Solutions; Creatine Kinase; Disease Models, Animal; Electrocardiography; Heart Rate; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Oxygen Consumption; Rats; Rats, Wistar | 1994 |
Experimental supplemental vein grafting and hypoperfusion syndrome.
Topics: Adenosine; Animals; Blood Flow Velocity; Coronary Angiography; Coronary Artery Bypass; Coronary Circulation; Disease Models, Animal; Dogs; Myocardial Ischemia; Phenylephrine; Saphenous Vein; Syndrome; Thoracic Arteries; Vascular Patency | 1995 |
Antihypertensive effects of 2-octynyladenosine (YT-146), a selective adenosine A2 receptor agonist, in Dahl salt-sensitive rats.
Topics: Adenosine; Administration, Oral; Alkynes; Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Hypertension; Male; Pulse; Purinergic P1 Receptor Agonists; Rats; Rats, Inbred Strains | 1994 |
The ATP-dependent potassium channel: an endogenous cardioprotective mechanism.
Topics: Acetylcholine; Adenosine; Animals; Anti-Arrhythmia Agents; Coronary Disease; Decanoic Acids; Disease Models, Animal; Dogs; Female; Glyburide; Hydroxy Acids; Infusions, Intravenous; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Potassium Channel Blockers; Potassium Channels | 1994 |
Transient adenosine infusion before ischemia and reperfusion protects against metabolic damage in pig hearts.
Topics: Adenosine; Adenosine Triphosphate; Animals; Coronary Circulation; Disease Models, Animal; Energy Metabolism; Heart Atria; Hydrogen-Ion Concentration; Infusions, Parenteral; Intracellular Fluid; Magnetic Resonance Imaging; Myocardial Reperfusion Injury; Myocardium; Phosphocreatine; Swine | 1995 |
Adenosine-mediated inhibition of platelet aggregation by acadesine. A novel antithrombotic mechanism in vitro and in vivo.
Topics: Adenosine; Adenosine Deaminase; Adenosine Kinase; Aminoimidazole Carboxamide; Animals; Aspirin; Blood Physiological Phenomena; Coronary Thrombosis; Coronary Vessels; Dipyridamole; Disease Models, Animal; Dogs; Erythrocytes; Humans; Male; Plasma; Platelet Aggregation; Purinergic P1 Receptor Antagonists; Regional Blood Flow; Ribonucleosides; Theophylline; Tubercidin | 1994 |
Systemic and myocardial effects of ATP and adenosine during hypoxic pulmonary hypertension in lambs.
Topics: Adenosine; Adenosine Triphosphate; Animals; Animals, Newborn; Disease Models, Animal; Heart; Humans; Infant, Newborn; Oxygen; Oxygen Consumption; Persistent Fetal Circulation Syndrome; Sheep | 1994 |
An immunosuppressed rat model for evaluation of anti-Cryptosporidium activity of sinefungin.
Topics: Adenosine; Animals; Coccidiostats; Cryptosporidiosis; Cryptosporidium parvum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Feces; Immunocompromised Host; Lasalocid; Male; Rats; Rats, Sprague-Dawley | 1994 |
CGS 21680 antagonizes motor hyperactivity in a rat model of Huntington's disease.
Topics: Adenosine; Amphetamine; Animals; Disease Models, Animal; Huntington Disease; Male; Motor Activity; Phenethylamines; Quinolinic Acid; Rats; Rats, Wistar | 1994 |
Protection of the right ventricular myocardium during acute right heart failure from pulmonary hypertension.
Topics: Acute Disease; Adenosine; Allopurinol; Animals; Cardioplegic Solutions; Disease Models, Animal; Embolectomy; Evaluation Studies as Topic; Extracorporeal Circulation; Glucose; Glutathione; Heart Arrest, Induced; Heart Failure; Hypertension, Pulmonary; Insulin; Male; Myocardial Reperfusion Injury; Organ Preservation Solutions; Pulmonary Embolism; Raffinose; Rats; Rats, Inbred Lew; Tromethamine; Ventricular Function, Right | 1994 |
Adenosine-induced bronchoconstriction and contraction of airway smooth muscle from allergic rabbits with late-phase airway obstruction: evidence for an inducible adenosine A1 receptor.
Topics: Adenosine; Animals; Asthma; Binding, Competitive; Bronchoconstriction; Disease Models, Animal; In Vitro Techniques; Lung; Muscle Contraction; Muscle, Smooth; Rabbits; Receptors, Purinergic P1; Trachea; Vaccination; Xanthines | 1994 |
Adenosine protects ultrastructure of isolated rat lungs against fat emulsion injury.
Topics: Adenosine; Animals; Disease Models, Animal; In Vitro Techniques; Lung; Male; Rats; Rats, Wistar; Respiratory Distress Syndrome | 1994 |
Intraosseous adenosine. As effective as peripheral or central venous administration?
Topics: Adenosine; Adolescent; Animals; Atrioventricular Node; Cardiac Pacing, Artificial; Catheterization, Central Venous; Child; Disease Models, Animal; Dose-Response Relationship, Drug; Electrocardiography; Heart Block; Heart Rate; Humans; Infusions, Intraosseous; Infusions, Intravenous; Random Allocation; Swine; Tachycardia, Supraventricular | 1994 |
Protective effect of an adenosine kinase inhibitor in septic shock.
Topics: Adenosine; Adenosine Kinase; Animals; Bacterial Infections; Base Sequence; Disease Models, Animal; DNA, Complementary; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Neutrophils; Peritonitis; Rats; Ribonucleosides; Shock, Septic; Tumor Necrosis Factor-alpha | 1994 |
Effects of adenosine on rate-dependent atrioventricular nodal function. Potential roles in tachycardia termination and physiological regulation.
Topics: Adenosine; Animals; Atrioventricular Node; Cardiac Pacing, Artificial; Disease Models, Animal; Electric Stimulation; Guinea Pigs; Heart Rate; In Vitro Techniques; Models, Cardiovascular; Perfusion; Rabbits; Tachycardia, Atrioventricular Nodal Reentry; Theophylline | 1993 |
The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.
Topics: Adenosine; Adenosine Deaminase; Aminoimidazole Carboxamide; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; Female; Inflammation; Kinetics; Leukocytes; Methotrexate; Mice; Mice, Inbred BALB C; Purinergic P1 Receptor Antagonists; Ribonucleotides; Spleen; Theobromine; Time Factors | 1993 |
Treatment of experimental acute corneal inflammation with inhibitors of the oxidative metabolism.
Topics: 6-Aminonicotinamide; Adenosine; Administration, Topical; Animals; Corneal Ulcer; Disease Models, Animal; Free Radicals; Keratitis; Luminescent Measurements; Ophthalmic Solutions; Oxidation-Reduction; Rabbits; Sodium Hydroxide | 1993 |
Adenosine contributes to neutrophil-mediated loss of myocardial function in post-ischemic guinea-pig hearts.
Topics: Adenosine; Adenosine Deaminase; Animals; Blood Flow Velocity; Cardiac Output; Coronary Circulation; Disease Models, Animal; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Lactates; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reperfusion Injury; Neutrophils; Receptors, Purinergic P1; Theophylline; Xanthines | 1993 |
An adenosine A1 receptor agonist, R(-)-N-(2-phenylisopropyl)-adenosine (PIA), but not adenosine itself, acts as a therapeutic preconditioning-mimetic agent in rabbits.
Topics: Adenosine; Animals; Blood Pressure; Coronary Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Heart Rate; Male; Myocardial Infarction; Myocardial Ischemia; Myocardium; Phenylisopropyladenosine; Rabbits; Receptors, Purinergic P1 | 1993 |
Protection from ischaemic-reperfusion injury with adenosine pretreatment is reversed by inhibition of ATP sensitive potassium channels.
Topics: Adenosine; Adenosine Triphosphate; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Glyburide; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Potassium Channels; Rabbits | 1993 |
Pretreatment with the adenosine A1 selective agonist, 2-chloro-N6-cyclopentyladenosine (CCPA), causes a sustained limitation of infarct size in rabbits.
Topics: Adenosine; Animals; Disease Models, Animal; Female; Male; Myocardial Infarction; Myocardial Ischemia; Myocardium; Rabbits; Receptors, Purinergic | 1993 |
Improved functional recovery by ischaemic preconditioning is not mediated by adenosine in the globally ischaemic isolated rat heart.
Topics: Adenosine; Animals; Coronary Circulation; Disease Models, Animal; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reperfusion Injury; Rats; Rats, Wistar; Regional Blood Flow; Theophylline | 1993 |
Immunomodulation by an inhibitor of S-adenosyl-L-homocysteine hydrolase: inhibition of in vitro and in vivo allogeneic responses.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Cyclosporine; Disease Models, Animal; Drug Evaluation, Preclinical; Graft Rejection; Graft Survival; Hydrolases; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Skin Transplantation; T-Lymphocytes | 1993 |
Effect of standard-dose versus high-dose epinephrine on myocardial high-energy phosphates during ventricular fibrillation and closed-chest CPR.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Biopsy; Blood Gas Analysis; Cardiopulmonary Resuscitation; Chromatography, High Pressure Liquid; Clinical Protocols; Disease Models, Animal; Drug Evaluation, Preclinical; Epinephrine; Guanosine Triphosphate; Heart Arrest; Hemodynamics; Injections, Intravenous; Inosine; Inosine Monophosphate; Myocardium; Phosphocreatine; Swine; Ventricular Fibrillation | 1993 |
Hypoxia enhances isoproterenol-induced increase in heart interstitial adenosine, depressing beta-adrenergic contractile responses.
Topics: Adenosine; Animals; Cell Hypoxia; Disease Models, Animal; Heart; Isoproterenol; Male; Myocardial Contraction; Myocardial Ischemia; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta | 1993 |
Characterization of the anticonvulsant properties of F-721.
Topics: Adenosine; Animals; Anticonvulsants; Cells, Cultured; Disease Models, Animal; Electric Stimulation; Furans; Kindling, Neurologic; Male; Membrane Potentials; Mice; Neurons; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Seizures | 1993 |
Diminished hyperaemic response of the hepatic artery to portal venous occlusion (the buffer response) in Asian hybrid minipigs: a comparison of the response to that observed in dogs.
Topics: Adenosine; Animals; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Feasibility Studies; Female; Hepatic Artery; Hepatic Veno-Occlusive Disease; Male; Regional Blood Flow; Swine; Swine, Miniature | 1993 |
Renal haemodynamic responses to adenosine in acute renal failure.
Topics: Acute Kidney Injury; Adenosine; Animals; Disease Models, Animal; Glycerol; Hemodynamics; Male; Mercuric Chloride; Rats; Rats, Wistar; Renal Circulation; Vasoconstriction; Xanthines | 1995 |
The anti-inflammatory mechanism of sulfasalazine is related to adenosine release at inflamed sites.
Topics: Acyltransferases; Adenosine; Aminoimidazole Carboxamide; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; Endothelium, Vascular; Female; Humans; Hydroxymethyl and Formyl Transferases; Mice; Mice, Inbred BALB C; Neutrophil Activation; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Ribonucleotides; Sulfasalazine | 1996 |
Pharmacology of the spinal adenosine receptor which mediates the antiallodynic action of intrathecal adenosine agonists.
Topics: Adenosine; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Spinal; Male; Pain; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Spinal Cord | 1996 |
Simultaneous measurement of cyclopentyladenosine-induced contraction and intracellular calcium in bronchial rings from allergic rabbits and it's antagonism.
Topics: Adenosine; Animals; Bronchi; Calcium; Disease Models, Animal; Dose-Response Relationship, Drug; Muscle Contraction; Muscle, Smooth; Rabbits; Theophylline | 1996 |
Intrathecal and systemic R-phenylisopropyl-adenosine reduces scratching behaviour in a rat mononeuropathy model.
Topics: Adenosine; Animals; Behavior, Animal; Disease Models, Animal; Injections, Spinal; Male; Motor Neuron Disease; Rats; Rats, Sprague-Dawley | 1996 |
Role of adenosine and nitric oxide in the hyperemic response to superficial and deep gastric mucosal injury and H+ back-diffusion in cats.
Topics: Adenosine; Animals; Cats; Diffusion; Disease Models, Animal; Gastric Acidity Determination; Gastric Mucosa; Hydrogen-Ion Concentration; Hyperemia; Indomethacin; Male; Nitric Oxide; Vasodilator Agents | 1996 |
Cerebral ischemia in gerbils: effects of acute and chronic treatment with adenosine A2A receptor agonist and antagonist.
Topics: Adenosine; Animals; Brain Ischemia; Caffeine; Cell Survival; Cerebrovascular Circulation; Cerebrovascular Disorders; Disease Models, Animal; Female; Gerbillinae; Hippocampus; Laser-Doppler Flowmetry; Neurons; Phenethylamines; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Treatment Outcome | 1995 |
DNA antisense therapy for asthma in an animal model.
Topics: Adenosine; Administration, Inhalation; Animals; Antigens, Dermatophagoides; Asthma; Bronchial Hyperreactivity; Cross-Over Studies; Disease Models, Animal; DNA, Antisense; Glycoproteins; Humans; Lung; Purinergic P1 Receptor Antagonists; Rabbits; Receptors, Purinergic P1; Respiratory Function Tests | 1997 |
Sodium-dependent adenosine transport is diminished in brush border membrane vesicles from hypothyroid rat kidney.
Topics: Adenosine; Animals; Biological Transport; Disease Models, Animal; Dose-Response Relationship, Drug; Hypothyroidism; Kidney; Microvilli; Rats; Sodium | 1997 |
Volatile anesthetics protect the ischemic rabbit myocardium from infarction.
Topics: Adenosine; Alkaloids; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Benzophenanthridines; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Female; Heart; Hemodynamics; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Phenanthridines; Protein Kinase C; Purinergic P1 Receptor Antagonists; Rabbits; Risk Factors | 1997 |
Selective adenosine A3 receptor stimulation reduces ischemic myocardial injury in the rabbit heart.
Topics: Adenosine; Animals; Disease Models, Animal; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Phenylisopropyladenosine; Rabbits; Receptors, Purinergic; Stimulation, Chemical | 1997 |
Effects of adenosine on pressure-flow relationships in an in vitro model of compartment syndrome.
Topics: Adenosine; Animals; Compartment Syndromes; Disease Models, Animal; Dogs; In Vitro Techniques; Vascular Resistance | 1997 |
Prevention of radiocontrast-induced nephropathy by adenosine antagonists in rats with chronic nitric oxide deficiency.
Topics: Acute Kidney Injury; Adenosine; Animals; Blood Pressure; Contrast Media; Disease Models, Animal; Enzyme Inhibitors; Glomerular Filtration Rate; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Renal Circulation; Theophylline; Vasoconstriction; Xanthines | 1997 |
Hypothermic ischaemia of the liver: a re-perfusion phenomenon.
Topics: Adenosine; Allopurinol; Animals; Biopsy; Cryopreservation; Disease Models, Animal; Glutathione; Insulin; Isotonic Solutions; Liver; Liver Function Tests; Organ Preservation; Organ Preservation Solutions; Platelet Count; Raffinose; Reperfusion Injury; Ringer's Lactate; Swine | 1997 |
Adenosine A2A agonists: a potential new type of atypical antipsychotic.
Topics: Adenosine; Animals; Antihypertensive Agents; Antipsychotic Agents; Catalepsy; Disease Models, Animal; Dose-Response Relationship, Drug; Locomotion; Male; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1 | 1997 |
Effect of adenosine and histamine receptor stimulation on canine histamine release to pentagastrin.
Topics: Adenosine; Animals; Dimaprit; Disease Models, Animal; Dogs; Female; Gas Chromatography-Mass Spectrometry; Gastric Mucosa; Histamine Agonists; Histamine Antagonists; Histamine Release; Male; Methylhistamines; Multivariate Analysis; Pentagastrin; Piperidines; Receptors, Histamine; Reference Values; Regional Blood Flow; Statistics, Nonparametric; Theophylline | 1997 |
Effects of ischemia, preconditioning, and adenosine deaminase inhibition on interstitial adenosine levels and infarct size.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Animals; Blood Flow Velocity; Disease Models, Animal; Enzyme Inhibitors; Extracellular Space; Female; Ischemic Preconditioning, Myocardial; Male; Microdialysis; Myocardial Infarction; Myocardial Ischemia; Pentostatin; Swine; Swine, Miniature | 1997 |
Energy status in anoxic rat hepatocytes: effects of isoflurane, solution composition, and hypothermia.
Topics: Adenine Nucleotides; Adenosine; Allopurinol; Anesthetics, Inhalation; Animals; Cell Hypoxia; Chromatography, High Pressure Liquid; Disease Models, Animal; Energy Metabolism; Glutathione; Hypothermia, Induced; Hypoxia; Insulin; Isoflurane; Isotonic Solutions; Liver; Male; Organ Preservation Solutions; Raffinose; Rats; Rats, Sprague-Dawley | 1995 |
Modulation of lithium-pilocarpine-induced status epilepticus by adenosinergic agents.
Topics: 2-Chloroadenosine; Adenosine; Animals; Anticonvulsants; Carbamazepine; Dipyridamole; Disease Models, Animal; Dose-Response Relationship, Drug; Lithium; Male; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus; Theophylline; Vasodilator Agents | 1997 |
Effects of adenosine on cardiopulmonary functions and oxygen-derived variables during endotoxemia.
Topics: Adenosine; Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Endotoxemia; Female; Heart; Hemodynamics; Infusions, Intravenous; Lung; Oxygen; Prospective Studies; Random Allocation; Salmonella Infections, Animal; Swine; Time Factors; Vasodilator Agents | 1998 |
Antinociception by adenosine analogs and inhibitors of adenosine metabolism in an inflammatory thermal hyperalgesia model in the rat.
Topics: Adenosine; Adenosine Deaminase; Animals; Antihypertensive Agents; Carrageenan; Deoxyadenosines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Edema; Enzyme Inhibitors; Excipients; Hot Temperature; Hyperalgesia; Male; Neuritis; Neurons; Nociceptors; Pentostatin; Phenethylamines; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Tubercidin | 1998 |
Chemiluminescence-based RNase protection assays for simultaneous quantification of procollagen mRNAs containing AU-rich regions.
Topics: Adenosine; Animals; Base Sequence; Chickens; Dinucleotide Repeats; Disease Models, Animal; Humans; Procollagen; Ribonucleases; RNA, Messenger; Scleroderma, Systemic; Uridine | 1998 |
Intrathecal administration of the adenosine A1 receptor agonist R-phenylisopropyl adenosine reduces presumed pain behaviour in a rat model of central pain.
Topics: Adenosine; Animals; Behavior, Animal; Cold Temperature; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Injections, Spinal; Nociceptors; Pain; Physical Stimulation; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Vasodilator Agents | 1998 |
Myocardial blood flow in awake dogs with chronic tricuspid regurgitation.
Topics: Adenosine; Animals; Cardiac Catheterization; Cardiomegaly; Chronic Disease; Coronary Circulation; Coronary Vessels; Disease Models, Animal; Dogs; Heart Atria; Heart Ventricles; Organ Size; Physical Exertion; Regional Blood Flow; Rest; Tricuspid Valve Insufficiency; Vascular Resistance; Vasodilator Agents | 1998 |
[Effect of A1 adenosine receptor blockade on postischemic damage to the coronary microcirculation].
Topics: Adenosine; Animals; Coronary Circulation; Disease Models, Animal; Microcirculation; Myocardial Ischemia; Myocardial Reperfusion; Rats; Rats, Wistar; Receptors, Purinergic P1 | 1998 |
Adenosine-enhanced ischemic preconditioning provides enhanced postischemic recovery and limitation of infarct size in the rabbit heart.
Topics: Adenosine; Animals; Cardioplegic Solutions; Coronary Circulation; Coronary Vessels; Disease Models, Animal; Heart Arrest, Induced; Infusions, Intra-Arterial; Ischemic Preconditioning, Myocardial; Myocardial Infarction; Myocardial Ischemia; Organ Size; Rabbits; Vasodilator Agents; Ventricular Function, Left | 1998 |
Intraspinal injection of adenosine agonists protect against L-NAME induced neuronal loss in the rat.
Topics: Adenosine; Animals; Disease Models, Animal; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Injections, Spinal; Male; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Purinergic P1 Receptor Agonists; Purinergic P2 Receptor Agonists; Rats; Rats, Long-Evans; Spinal Cord | 1998 |
Modulation of spinal pain mechanisms by spinal cord stimulation and the potential role of adjuvant pharmacotherapy.
Topics: Adenosine; Animals; Baclofen; Behavior, Animal; Chemotherapy, Adjuvant; Combined Modality Therapy; Disease Models, Animal; Electric Stimulation Therapy; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Injections, Spinal; Male; Pain; Pain Management; Pain Threshold; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, Purinergic P1; Spinal Cord; Touch; Treatment Outcome | 1997 |
Suppression of macrophage inflammatory protein (MIP)-1alpha production and collagen-induced arthritis by adenosine receptor agonists.
Topics: Adenosine; Animals; Arthritis; Cells, Cultured; Chemokine CCL3; Chemokine CCL4; Collagen; Cytokines; Disease Models, Animal; Gene Expression; Macrophage Activation; Macrophage Inflammatory Proteins; Macrophages; Mice; Mice, Inbred DBA; Purinergic P1 Receptor Agonists; RNA, Messenger | 1998 |
Adenosine receptor antagonism affects regional resting vascular resistance during rat peritoneal sepsis.
Topics: Adenosine; Animals; Cardiac Output; Disease Models, Animal; Hemodynamics; Male; Organ Specificity; Peritonitis; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Sepsis; Theophylline; Vascular Resistance | 1998 |
A study of adenosine treatment in experimental acute spinal cord injury. Effect on arachidonic acid metabolites.
Topics: Acute Disease; Adenosine; Animals; Arachidonic Acid; Dinoprostone; Disease Models, Animal; Laminectomy; Leukotriene C4; Lipid Peroxidation; Male; Myelin Sheath; Nerve Compression Syndromes; Random Allocation; Rats; Rats, Wistar; Spinal Cord; Spinal Cord Injuries; Vasodilator Agents | 1999 |
[The central mechanisms regulating the blood circulation in hyperuricemia].
Topics: Adenosine; Animals; Blood Circulation; Brain; Brain Chemistry; Cyclic AMP; Cyclic GMP; Disease Models, Animal; Electrophysiology; Gout; Heart; Male; Rats; Time Factors; Uric Acid | 1999 |
Effects of dexamethasone on airway hyper-responsiveness to the adenosine A1 receptor agonist cyclo-pentyl adenosine in an allergic rabbit model.
Topics: Adenosine; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Count; Cell Division; Dexamethasone; Disease Models, Animal; Female; Glucocorticoids; Hypersensitivity; Leukocytes, Mononuclear; Male; Phytohemagglutinins; Purinergic P1 Receptor Agonists; Rabbits | 1999 |
Intrathecal adenosine: interactions with spinal clonidine and neostigmine in rat models of acute nociception and postoperative hypersensitivity.
Topics: Adenosine; Analgesics, Non-Narcotic; Animals; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Male; Neostigmine; Pain, Postoperative; Rats; Rats, Sprague-Dawley | 1999 |
Validation of minimally invasive measurement of myocardial perfusion using electron beam computed tomography and application in human volunteers.
Topics: Adenosine; Adolescent; Adult; Animals; Contrast Media; Coronary Angiography; Coronary Circulation; Disease Models, Animal; Dogs; Feasibility Studies; Humans; Iohexol; Male; Microspheres; Reproducibility of Results; Tomography, X-Ray Computed; Vasodilator Agents | 1999 |
Superior protection in orthotopic rat lung transplantation with cyclic adenosine monophosphate and nitroglycerin-containing preservation solution.
Topics: Adenosine; Allopurinol; Animals; Capillary Permeability; Cyclic AMP; Dextrans; Disease Models, Animal; Drug Evaluation, Preclinical; Glucose; Glutathione; Graft Survival; Hypertonic Solutions; Insulin; Lung Transplantation; Male; Nitroglycerin; Organ Preservation Solutions; Pulmonary Circulation; Raffinose; Rats; Rats, Inbred Lew; Survival Analysis; Vasodilator Agents | 1999 |
Neutrophil A2A adenosine receptor inhibits inflammation in a rat model of meningitis: synergy with the type IV phosphodiesterase inhibitor, rolipram.
Topics: Adenosine; Animals; Blood-Brain Barrier; Cell Adhesion; Cyclic AMP; Disease Models, Animal; Drug Synergism; Humans; Leukocytosis; Meningitis, Bacterial; Neutrophil Activation; Neutrophils; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; Respiratory Burst; Rolipram; Superoxides; Triazines; Triazoles; Tumor Necrosis Factor-alpha | 1999 |
Myocardial uptake of (99m)Tc-N-NOET and (201)Tl during dobutamine infusion. Comparison with adenosine stress.
Topics: Adenosine; Animals; Coronary Circulation; Coronary Disease; Coronary Vessels; Disease Models, Animal; Dobutamine; Dogs; Drug Interactions; Heart; Myocardium; Organotechnetium Compounds; Radionuclide Imaging; Stress, Physiological; Technetium Tc 99m Sestamibi; Thallium Radioisotopes; Thiocarbamates | 1999 |
Intrathecal adenosine interacts with a spinal noradrenergic system to produce antinociception in nerve-injured rats.
Topics: Adenosine; Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Spinal; Ligation; Male; Nociceptors; Norepinephrine; Pain; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Spinal Cord; Spinal Nerve Roots | 1999 |
Striatal outflow of adenosine, excitatory amino acids, gamma-aminobutyric acid, and taurine in awake freely moving rats after middle cerebral artery occlusion: correlations with neurological deficit and histopathological damage.
Topics: Adenosine; Animals; Arterial Occlusive Diseases; Brain Ischemia; Cerebral Cortex; Chromatography, High Pressure Liquid; Corpus Striatum; Disease Models, Animal; Excitatory Amino Acids; gamma-Aminobutyric Acid; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Male; Microdialysis; Middle Cerebral Artery; Neurologic Examination; Neurotransmitter Agents; Psychomotor Performance; Rats; Rats, Wistar; Suture Techniques; Taurine | 1999 |
Endogenous adenosine protects CA1 neurons from kainic acid-induced neuronal cell loss in the rat hippocampus.
Topics: Adenosine; Animals; Apoptosis; Disease Models, Animal; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Hippocampus; Histocompatibility Antigens Class II; Injections, Intraventricular; Kainic Acid; Macrophage-1 Antigen; Male; Microtubule-Associated Proteins; Nerve Degeneration; Neuroglia; Neurons; Phosphorylation; Proto-Oncogene Proteins c-jun; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Theophylline | 1999 |
Administration of adenosine during reperfusion reduces injury of vascular endothelium and death of myocytes.
Topics: Adenosine; Animals; Apoptosis; CD18 Antigens; Creatine Kinase; Disease Models, Animal; Dogs; Endothelium, Vascular; Female; In Situ Nick-End Labeling; Infusions, Intra-Arterial; Intercellular Adhesion Molecule-1; Male; Myocardial Reperfusion Injury; Myocardium; Neutrophil Activation; Neutrophils; Peroxidase; Vasodilator Agents | 1999 |
Seizure suppression in kindled rats by intraventricular grafting of an adenosine releasing synthetic polymer.
Topics: Adenosine; Animals; Anticonvulsants; Biocompatible Materials; Cattle; Cerebral Ventricles; Delayed-Action Preparations; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Implants; Electroencephalography; Epilepsy, Temporal Lobe; Feasibility Studies; Kindling, Neurologic; Male; Neuroprotective Agents; Polyvinyls; Rats; Rats, Sprague-Dawley; Seizures; Serum Albumin, Bovine | 1999 |
5' nucleotidase and adenosine during retinal vasculogenesis and oxygen-induced retinopathy.
Topics: 5'-Nucleotidase; Adenosine; Animals; Animals, Newborn; Densitometry; Disease Models, Animal; Dogs; Histocytochemistry; Humans; Hyperoxia; Immunoenzyme Techniques; Infant, Newborn; Oxygen; Retina; Retinal Neovascularization; Retinal Vessels; Retinopathy of Prematurity; von Willebrand Factor | 2000 |
Low-potassium University of Wisconsin solution for cardioplegia: improved protection of the isolated ischemic neonatal rabbit heart.
Topics: Adenosine; Adenosine Triphosphate; Allopurinol; Animals; Animals, Newborn; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; Heart; Heart Arrest; Heart Arrest, Induced; Hemodynamics; Hypothermia, Induced; In Vitro Techniques; Insulin; Magnesium; Organ Preservation Solutions; Phosphocreatine; Potassium; Potassium Chloride; Rabbits; Raffinose; Sodium Chloride | 1999 |
Adenosine by aortic flush fails to augment the brain preservation effect of mild hypothermia during exsanguination cardiac arrest in dogs - an exploratory study.
Topics: Adenosine; Animals; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; Dogs; Heart Arrest; Hemodynamics; Hypothermia, Induced; Infusions, Intra-Arterial; Male; Reference Values; Shock, Hemorrhagic; Survival Rate; Vasodilator Agents | 2000 |
Reduction of A1 adenosine receptors in rat hippocampus after kainic acid-induced limbic seizures.
Topics: Adenosine; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Neurons; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Seizures; Somatosensory Cortex | 2000 |
N(6)-2-(4-aminophenyl)ethyl-adenosine enhances the anticonvulsive action of conventional antiepileptic drugs in the kindling model of epilepsy in rats.
Topics: Adenosine; Amygdala; Animals; Anticonvulsants; Avoidance Learning; Carbamazepine; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Epilepsy; Kindling, Neurologic; Male; Rats; Rats, Wistar; Theophylline; Valproic Acid | 2000 |
Retrograde venous perfusion with hypothermic saline and adenosine for protection of the ischemic spinal cord.
Topics: Adenosine; Animals; Aorta; Constriction; Disease Models, Animal; Female; Hypothermia, Induced; Intraoperative Complications; Ischemia; Male; Perfusion; Sodium Chloride; Spinal Cord; Swine; Vasodilator Agents | 2000 |
The use of enzyme therapy to regulate the metabolic and phenotypic consequences of adenosine deaminase deficiency in mice. Differential impact on pulmonary and immunologic abnormalities.
Topics: Adenosine; Adenosine Deaminase; Adenosylhomocysteinase; Animals; Deoxyadenine Nucleotides; Deoxyadenosines; Disease Models, Animal; Genotype; Histocytochemistry; Hydrolases; Killer Cells, Natural; Lung; Lymphocyte Count; Lymphocytes; Lymphopenia; Mice; Mice, Transgenic; Phenotype; S-Adenosylhomocysteine; Severe Combined Immunodeficiency; Spleen; Thymus Gland | 2000 |
Evidence for increased dorsal hippocampal adenosine release and metabolism during pharmacologically induced seizures in rats.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Bicuculline; Convulsants; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Excitatory Amino Acid Agonists; GABA Antagonists; Guanosine; Hippocampus; Hypoxanthine; Inosine; Kainic Acid; Male; Microdialysis; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Xanthine | 2000 |
Purine-induced alterations of dopamine metabolism in rat pheochromocytoma PC12 cells.
Topics: Adenine; Adenosine; Animals; Disease Models, Animal; Dopamine; Guanine; Guanosine; Hypoxanthine; Neostriatum; Neural Pathways; Neurons; Parkinson Disease; PC12 Cells; Purines; Rats; Substantia Nigra; Uric Acid; Xanthine | 2000 |
Post-ischemic intraportal adenosine administration protects against reperfusion injury of canine liver.
Topics: Adenosine; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Disease Models, Animal; Dogs; Female; Free Radicals; Hepatic Veins; Infusions, Intravenous; Liver; Probability; Reference Values; Reperfusion Injury; Survival Rate; Vasodilator Agents | 2000 |
CGS 21680 exerts marked antidystonic effects in a genetic model of paroxysmal dyskinesia.
Topics: Adenosine; Animals; Chorea; Cricetinae; Disease Models, Animal; Drug Evaluation, Preclinical; Dystonia; Models, Genetic; Phenethylamines; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1; Stress, Psychological | 2000 |
Electrophysiological and behavioural evidence for an antagonistic modulatory role of adenosine A2A receptors in dopamine D2 receptor regulation in the rat dopamine-denervated striatum.
Topics: Adenosine; Animals; Corpus Striatum; Denervation; Disease Models, Animal; Dopamine; Functional Laterality; Humans; Male; Oxidopamine; Parkinson Disease; Phenethylamines; Purinergic P1 Receptor Antagonists; Quinpirole; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Dopamine D2; Receptors, Purinergic P1; Reference Values | 2000 |
The metabolic rate and vulnerability of dopaminergic neurons, and adenosine dynamics in the cerebral cortex, nucleus accumbens, caudate nucleus, and putamen of the common marmoset.
Topics: Adenosine; Animals; Callithrix; Caudate Nucleus; Cerebral Cortex; Disease Models, Animal; Dopamine; Microdialysis; Neural Conduction; Nucleus Accumbens; Parkinsonian Disorders; Putamen | 2000 |
Anti-stunning and anti-infarct effects of adenosine-enhanced ischemic preconditioning.
Topics: Adenosine; Animals; Disease Models, Animal; Female; Heart Function Tests; Hemodynamics; Ischemic Preconditioning, Myocardial; Linear Models; Male; Myocardial Infarction; Myocardial Stunning; Organ Size; Recovery of Function; Sheep; Time Factors | 2000 |
Endogenous adenosine and secondary injury after chest trauma.
Topics: Acidosis; Adenosine; Aminoimidazole Carboxamide; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Drug Evaluation, Preclinical; Hemodynamics; Hypercapnia; Inflammation; Leukocyte Count; Peroxidase; Ribonucleosides; Survival Analysis; Swine; Thoracic Injuries; Wounds, Nonpenetrating | 2000 |
Persantine attenuates hemorrhagic shock-induced P-selectin expression.
Topics: Adenosine; Animals; Colon; Dipyridamole; Disease Models, Animal; Drug Evaluation, Preclinical; Intestine, Small; Kidney; Liver; Lung; Mice; Mice, Inbred C57BL; Myocardium; P-Selectin; Phosphodiesterase Inhibitors; Reperfusion Injury; Resuscitation; Shock, Hemorrhagic; Stomach; Up-Regulation | 2000 |
Acadesine and intestinal barrier function after hemorrhagic shock and resuscitation.
Topics: Adenosine; Adenosine Kinase; Aminoimidazole Carboxamide; Animals; Blood Flow Velocity; Capillary Permeability; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Fluid Therapy; Formycins; Ileum; Intestinal Mucosa; Ischemia; Laser-Doppler Flowmetry; Male; Resuscitation; Ribonucleosides; Shock, Hemorrhagic; Swine | 2000 |
Sildenafil citrate (Viagra) does not exacerbate myocardial ischemia in canine models of coronary artery stenosis.
Topics: Adenosine; Animals; Blood Flow Velocity; Coronary Circulation; Coronary Disease; Disease Models, Animal; Dogs; Piperazines; Platelet Aggregation; Purines; Sildenafil Citrate; Sulfones | 2001 |
Dysregulation of extracellular adenosine levels by vascular smooth muscle cells from spontaneously hypertensive rats.
Topics: Adenosine; Animals; Disease Models, Animal; Hypertension; Muscle, Smooth, Vascular; Rats; Rats, Inbred SHR; Umbilical Veins | 2001 |
Coronary sinus occlusion enhances coronary collateral flow and reduces subendocardial ischemia.
Topics: Adenosine; Anesthesia; Animals; Blood Pressure; Collateral Circulation; Coronary Circulation; Coronary Disease; Disease Models, Animal; Dogs; Endocardium; Heart Rate; Hyperemia; Myocardial Ischemia; Vasodilation; Vasodilator Agents; Ventricular Pressure | 2001 |
Antiadrenergic effects of adenosine in pressure overload hypertrophy.
Topics: Adenosine; Adrenergic Antagonists; Adrenergic beta-Agonists; Animals; Blood Pressure; Body Weight; Caffeine; Calcium; Cardiomegaly; Cells, Cultured; Coronary Circulation; Disease Models, Animal; Echocardiography; In Vitro Techniques; Inosine; Isoproterenol; Male; Myocardial Contraction; Myocardium; Organ Size; Perfusion; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley | 2001 |
Investigation of mechanisms that mediate reactive hyperaemia in guinea-pig hearts: role of K(ATP) channels, adenosine, nitric oxide and prostaglandins.
Topics: Adenosine; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Heart Diseases; Hyperemia; Male; Membrane Proteins; Nitric Oxide; Potassium Channels; Prostaglandins | 2001 |
Blood purine and energy status in rats with colitis.
Topics: Acetic Acid; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Biomarkers; Chromatography, High Pressure Liquid; Colitis; Disease Models, Animal; Energy Metabolism; Hemoglobins; Inosine; Male; Peroxidase; Purines; Rats; Rats, Wistar; Time Factors; Uric Acid | 2001 |
Changes in fetal plasma adenosine and xanthine concentrations during fetal asphyxia with maternal oxygen administration in ewes.
Topics: Adenosine; Animals; Asphyxia; Blood Gas Analysis; Blood Pressure; Disease Models, Animal; Female; Fetal Hypoxia; Heart Rate; Hypoxanthine; Oxygen; Sheep; Xanthine | 2000 |
Energy-related metabolites during and after induced myocardial infarction with special emphasis on the reperfusion injury after extracorporeal circulation.
Topics: Adenosine; Animals; Chromatography, High Pressure Liquid; Dialysis Solutions; Disease Models, Animal; Energy Metabolism; Extracorporeal Circulation; Guanine; Heart Arrest, Induced; Hypoxanthine; Inosine; Lactic Acid; Microdialysis; Myocardial Infarction; Myocardium; Pyruvic Acid; Reperfusion Injury; Swine; Taurine | 2001 |
ADAR1 is involved in the development of microvascular lung injury.
Topics: Adenosine; Adenosine Deaminase; Animals; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Endotoxins; Escherichia coli; In Situ Hybridization; Inosine; Interferon-gamma; Leukocytes; Lung; Macrophages, Alveolar; Mice; Mice, Inbred C57BL; Microcirculation; Pulmonary Circulation; Pulmonary Edema; Respiratory Distress Syndrome; RNA Editing; RNA-Binding Proteins; RNA, Messenger; Up-Regulation | 2001 |
Effects of adenosine administration on spike-wave discharge frequency in genetically epileptic rats.
Topics: Adenosine; Animals; Disease Models, Animal; Electroencephalography; Epilepsy; Male; Rats | 2001 |
Adenosine analogue reduces spinal cord reperfusion injury in a time-dependent fashion.
Topics: Adenosine; Animals; Aorta, Thoracic; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug Administration Schedule; Neurologic Examination; Purinergic P1 Receptor Agonists; Purines; Rabbits; Receptor, Adenosine A2A; Recovery of Function; Reperfusion Injury; Spinal Cord; Surgical Instruments | 2001 |
Effects of adenosine receptor agonists and antagonists in a genetic animal model of primary paroxysmal dystonia.
Topics: Adenosine; Animals; Caffeine; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Dystonia; Female; Male; Mesocricetus; Muscle Contraction; Mutation; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Theobromine; Theophylline; Triazines; Triazoles; Xanthines | 2001 |
Activation of adenosine A1 receptors by drugs to lower plasma glucose in streptozotocin-induced diabetic rats.
Topics: Adenosine; Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Dipyridamole; Disease Models, Animal; Dose-Response Relationship, Drug; Glucose; Glycogen; Hypoglycemic Agents; Insulin; Male; Muscle, Skeletal; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Streptozocin; Theophylline; Triglycerides; Xanthines | 2000 |
Effects of adenosine on thrombosis and thrombolysis in a canine experimental preparation.
Topics: Adenosine; Adenosine Diphosphate; Animals; Arachidonic Acid; Blood Flow Velocity; Carotid Arteries; Carotid Artery Thrombosis; Coronary Circulation; Coronary Thrombosis; Disease Models, Animal; Dogs; Electric Injuries; Female; Fibrinolytic Agents; Male; Platelet Aggregation; Thrombolytic Therapy; Time Factors; Tissue Plasminogen Activator | 2001 |
Decrease in coronary blood flow reserve during hyperlipidemia is secondary to an increase in blood viscosity.
Topics: Adenosine; Animals; Arterioles; Blood Flow Velocity; Blood Pressure; Blood Viscosity; Blood Volume; Calcium Chloride; Capillary Resistance; Coronary Circulation; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Echocardiography; Fat Emulsions, Intravenous; Hyperemia; Hyperlipidemias; Mice; Mice, Inbred C57BL; Microspheres; Muscle, Skeletal; Triglycerides; Venules | 2001 |
Adenosine A2A, 5-HT1A and 5-HT7 receptor in neonatally pregnenolone-treated rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenosine; Aging; Animals; Animals, Newborn; Antihypertensive Agents; Binding, Competitive; Cerebral Cortex; Disease Models, Animal; Dopamine; Female; Male; Mental Disorders; Phenethylamines; Pregnancy; Pregnenolone; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Receptor Agonists; Sex Characteristics; Synaptic Transmission | 2001 |
[Adenosine in treatment of rats with spinal cord injury].
Topics: 2-Chloroadenosine; Adenosine; Animals; Calcium; Disease Models, Animal; Extracellular Space; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries | 2000 |
A novel analgesic compound OT-7100 attenuates nociceptive responses in animal models of inflammatory and neuropathic hyperalgesia: a possible involvement of adenosinergic anti-nociception.
Topics: Adenosine; Analgesics, Non-Narcotic; Animals; Disease Models, Animal; Guinea Pigs; Hyperalgesia; Immunohistochemistry; In Vitro Techniques; Male; Proto-Oncogene Proteins c-fos; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Theobromine; Xanthines | 2001 |
Ischemic cardiomyopathy in pigs with two-vessel occlusion and viable, chronically dysfunctional myocardium.
Topics: Adenosine; Animals; Coronary Circulation; Coronary Stenosis; Coronary Vessels; Disease Models, Animal; Heart; Heart Failure; Hemodynamics; Myocardial Ischemia; Perfusion; Reference Values; Swine; Systole; Time Factors; Vasoconstriction; Ventricular Dysfunction, Left; Ventricular Function, Left | 2002 |
Tissue levels of S-adenosylhomocysteine in the rat kidney: effects of ischemia and homocysteine.
Topics: Adenosine; Animals; Disease Models, Animal; Homocysteine; Hyperhomocysteinemia; Ischemia; Kidney Diseases; Male; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine | 2002 |
Effects of the adenosine A(1) receptor agonist N(6)-cyclopentyladenosine on phencyclidine-induced behavior and expression of the immediate-early genes in the discrete brain regions of rats.
Topics: Adenosine; Animals; Antipsychotic Agents; Brain; Cytoskeletal Proteins; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Gene Expression; Genes, Immediate-Early; Gyrus Cinguli; Hallucinogens; Head Movements; Male; Motor Activity; Nerve Tissue Proteins; Nucleus Accumbens; Phencyclidine; Prefrontal Cortex; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Psychotic Disorders; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P1; RNA, Messenger | 2002 |
Humoral effects of selective adenosine agonists in spontaneously hypertensive rats.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Antihypertensive Agents; Atrial Natriuretic Factor; Blood Pressure; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin-1; Heart Rate; Male; Models, Cardiovascular; Purinergic P1 Receptor Agonists; Rats; Rats, Inbred SHR; Renin | 1996 |
Determinants of hepatitis C translational initiation in vitro, in cultured cells and mice.
Topics: 3' Untranslated Regions; Adenosine; Animals; Disease Models, Animal; HeLa Cells; Hepacivirus; Hepatitis C; Humans; In Vitro Techniques; Liver; Luciferases; Mice; Placental Hormones; Polymers; Protein Biosynthesis; RNA, Messenger; RNA, Viral | 2002 |
Protective effect of resveratrol against pentylenetetrazole-induced seizures and its modulation by an adenosinergic system.
Topics: Adenosine; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Injections, Intraperitoneal; Male; Pentylenetetrazole; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Resveratrol; Seizures; Stilbenes; Theophylline | 2002 |
Adenosine A(1)-receptor induced late preconditioning and myocardial infarction: reperfusion duration is critical.
Topics: Adenosine; Animals; Cardiac Catheterization; Coronary Vessels; Disease Models, Animal; Disease Progression; Heart Ventricles; Hemodynamics; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Purinergic P1 Receptor Agonists; Rabbits; Receptors, Purinergic P1; Time Factors; Treatment Outcome; Wakefulness | 2002 |
3-deazaneplanocin A induces massively increased interferon-alpha production in Ebola virus-infected mice.
Topics: Adenosine; Animals; Disease Models, Animal; Ebolavirus; Female; Hemorrhagic Fever, Ebola; Immunohistochemistry; Interferon-alpha; Liver; Mice; Mice, Inbred BALB C; Viremia | 2002 |
Abnormal myocardial fluid retention as an early manifestation of ischemic injury.
Topics: Adenosine; Adenosine Triphosphatases; Animals; Cell Membrane; Coronary Circulation; Coronary Disease; Disease Models, Animal; Dogs; Edema; Heart Rate; Ligation; Myocardium; Nitroglycerin; Organ Size | 1977 |
Coronary reperfusion: effects of vasodilators (papaverine and adenosine).
Topics: Adenosine; Animals; Coronary Circulation; Coronary Vessels; Disease Models, Animal; Dogs; Injections, Intravenous; Ischemia; Papaverine; Perfusion; Vascular Resistance | 1977 |
Sephadex-induced reduction of coronary flow in the isolated rat heart: a model for ischemic heart disease.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Blood Pressure; Coronary Disease; Disease Models, Animal; Hypoxanthines; Hypoxia; In Vitro Techniques; Inosine; Male; Microspheres; Myocardial Contraction; Myocardium; Perfusion; Phosphocreatine; Polysaccharides; Rats; Sepharose | 1977 |
Coronary steal: its role in detrimental effect of isoproterenol after acute coronary occlusion in dogs.
Topics: Adenosine; Animals; Blood Pressure; Collateral Circulation; Coronary Circulation; Disease Models, Animal; Dogs; Isoproterenol; Myocardial Infarction | 1976 |
Myocardial reactive hyperemia.
Topics: Adenosine; Animals; Coronary Circulation; Coronary Disease; Coronary Vessels; Disease Models, Animal; Dogs; Hyperemia; Muscle, Smooth; Myocardium; Oxygen Consumption; Prostaglandins; Vascular Resistance | 1975 |
Release of (14C) adenosine from the guinea pig heart during autoregulation.
Topics: Adenosine; Animals; Coronary Circulation; Coronary Disease; Disease Models, Animal; Guinea Pigs; Hypoxia; Myocardium; Oxygen; Perfusion | 1975 |
cAMP production via the adenylyl cyclase pathway is reduced in RCS rat RPE.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Disease Models, Animal; Pigment Epithelium of Eye; Prostaglandins E; Rats; Rats, Mutant Strains; Receptors, Prostaglandin; Receptors, Purinergic; Retinal Degeneration; Signal Transduction; Vasodilator Agents | 1992 |
A1 adenosine receptors express seizure-suppressant activity in the rat prepiriform cortex.
Topics: Adenosine; Amygdala; Animals; Brain Mapping; Culture Techniques; Disease Models, Animal; Limbic System; Neural Inhibition; Neural Pathways; Rats; Receptors, Purinergic; Seizures; Synaptic Transmission | 1992 |
Comparison of single-photon emission computed tomographic (SPECT) myocardial perfusion imaging with thallium-201 and technetium-99m sestamibi in dogs.
Topics: Adenosine; Animals; Blood Flow Velocity; Blood Pressure; Coronary Disease; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Electrocardiography; Hemodynamics; Sensitivity and Specificity; Severity of Illness Index; Technetium Tc 99m Sestamibi; Thallium Radioisotopes; Tomography, Emission-Computed, Single-Photon; Vascular Patency | 1992 |
Superoxide dismutase enhances ischemia-induced reactive hyperemic flow and adenosine release in dogs. A role of 5'-nucleotidase activity.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Triphosphate; Animals; Coronary Disease; Disease Models, Animal; Dogs; Free Radicals; Hyperemia; Myocardium; Superoxide Dismutase | 1992 |
Variations of lipid profile in animals caused by adenosine analogs: N6 (amido-3-propyl) adenosine hydrochloride and (carboxamido-3-propylamino)-6-(triproprionyl) 2',3',5'beta (D-ribosyl)-9-purine.
Topics: Adenosine; Animals; Cholesterol; Disease Models, Animal; Fatty Acids; Hypertriglyceridemia; Lipids; Lipoproteins, HDL; Lipoproteins, VLDL; Male; Phospholipids; Prodrugs; Purine Nucleosides; Rabbits; Rats; Rats, Inbred Strains; Triglycerides | 1992 |
Adenosine for controlled hypotension: systemic compared with intracoronary infusion in dogs.
Topics: Adenosine; Animals; Coronary Disease; Coronary Vessels; Disease Models, Animal; Dogs; Female; Hemodynamics; Hyperemia; Hypotension; Hypotension, Controlled; Infusions, Intra-Arterial; Infusions, Intravenous; Male | 1992 |
Effects of adenosine, an adenosine-A1 antagonist, and their combination in splanchnic occlusion shock in rats.
Topics: Adenosine; Animals; Cathepsin D; Disease Models, Animal; Drug Interactions; Hemodynamics; Ischemia; Male; Myocardial Depressant Factor; Purinergic Antagonists; Rats; Rats, Inbred Strains; Reperfusion; Splanchnic Circulation; Xanthines | 1992 |
Secondary generalization in non-kindled rats following acute administration of GABA-complex and adenosine antagonists.
Topics: Adenosine; Aminophylline; Amygdala; Animals; Bicuculline; Carbolines; Cerebral Cortex; Disease Models, Animal; Electrodes, Implanted; Epilepsies, Partial; GABA Antagonists; Harmine; Kindling, Neurologic; Male; Picrotoxin; Rats | 1990 |
[New adenosine derivatives as agents to prevent postischemic disorders].
Topics: Acute Disease; Adenosine; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Hypoxia; Ischemia; Liver; Male; Rats | 1991 |
Endothelium dependent vasodilatation following brief ischaemia and reperfusion in anaesthetised swine.
Topics: Adenosine; Adenosine Triphosphate; Animals; Coronary Disease; Coronary Vessels; Disease Models, Animal; Endothelium, Vascular; Female; Male; Myocardial Reperfusion; Pacemaker, Artificial; Regional Blood Flow; Swine; Vascular Resistance; Vasodilation | 1991 |
[Cardioprotective effect of combined use of coenzyme Q9 and cyclohexyladenosine in ischemia, reperfusion and acute myocardial infarction].
Topics: Adenosine; Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Heart Arrest, Induced; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Rats; Rats, Inbred Strains; Ubiquinone | 1991 |
Effect of intravenous adenosine on myocardial reperfusion injury in a model with low myocardial collateral blood flow.
Topics: Adenosine; Animals; Collateral Circulation; Coronary Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Infusions, Intravenous; Male; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardium; Rabbits; Time Factors | 1991 |
Alterations in collateral blood flow produced by isoflurane in a chronically instrumented canine model of multivessel coronary artery disease.
Topics: Adenosine; Animals; Collateral Circulation; Coronary Circulation; Coronary Disease; Disease Models, Animal; Dogs; Female; Hemodynamics; Isoflurane; Male | 1991 |
Sinefungin as treatment for American Leishmania in sensitive BALB/c and resistant C57BL/6 mice.
Topics: Adenosine; Animals; Antiprotozoal Agents; Cells, Cultured; Disease Models, Animal; Immunity, Innate; Leishmania; Leishmaniasis; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Molecular Structure | 1990 |
Effect of adenosine in some models of inflammation and anaphylaxis in experimental animals.
Topics: Adenosine; Anaphylaxis; Animals; Disease Models, Animal; Female; Guinea Pigs; Inflammation; Male; Mice; Mice, Inbred C57BL; Ozone; Pulmonary Edema; Rats; Rats, Inbred Strains | 1989 |
Adenosine receptor alterations in nervous pointer dogs: a preliminary report.
Topics: Adenosine; Animals; Anxiety Disorders; Brain; Cerebellum; Disease Models, Animal; Dog Diseases; Dogs; Receptors, GABA-A; Receptors, Purinergic; Tritium | 1987 |
Coronary vascular reserve in the greyhound with left ventricular hypertrophy.
Topics: Adenosine; Animals; Blood Pressure; Cardiac Pacing, Artificial; Cardiomegaly; Coronary Vessels; Disease Models, Animal; Dogs; Heart Rate; Physical Exertion | 1986 |
Purine nucleoside--mediated immobility in mice: reversal by antidepressants.
Topics: 2-Chloroadenosine; Adenosine; Adrenergic Fibers; Animals; Antidepressive Agents; Depressive Disorder; Disease Models, Animal; Female; Humans; Male; Mice; Receptors, Neurotransmitter; Receptors, Purinergic | 1985 |
Adenosine inhibits exocytotic release of endogenous noradrenaline in rat heart: a protective mechanism in early myocardial ischemia.
Topics: Adenosine; Animals; Chromatography, High Pressure Liquid; Coronary Circulation; Coronary Disease; Disease Models, Animal; Electric Stimulation; Exocytosis; Heart; Male; Myocardium; Norepinephrine; Phenylisopropyladenosine; Rats; Theophylline | 1987 |
An animal model for adenosine-induced bronchoconstriction.
Topics: Adenosine; Airway Resistance; Animals; Biomechanical Phenomena; Bronchi; Bronchial Spasm; Disease Models, Animal; Lung Compliance; Rats; Receptors, Purinergic; Xanthines | 1987 |
Rapid down regulation of hippocampal adenosine receptors following brief anoxia.
Topics: Adenosine; Animals; Autoradiography; Brain; Disease Models, Animal; Gerbillinae; Hippocampus; Male; Receptors, Purinergic | 1986 |
Effect of hyperaemia on thallium-201 redistribution in normal canine myocardium.
Topics: Adenosine; Animals; Disease Models, Animal; Dogs; Hyperemia; Kinetics; Male; Myocardium; Radioisotopes; Regional Blood Flow; Thallium | 1985 |
Effects of chronic hypertension on vasa vasorum in the thoracic aorta.
Topics: Adenosine; Animals; Aorta, Thoracic; Chronic Disease; Disease Models, Animal; Dogs; Hypertension; Regional Blood Flow; Vasa Vasorum; Vasodilation | 1985 |
Adenosine deaminase activity in livers of congenitally athymic nude mice.
Topics: Adenosine; Aminohydrolases; Animals; Disease Models, Animal; Female; Genes, Recessive; Immunologic Deficiency Syndromes; Liver; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mutation; Thymus Gland | 1974 |
[Effect of hexobendine on the coronary efficacy of generalized hypoxia as well as of i.cor. and i.v. single injections of adenosine in dogs].
Topics: Adenosine; Animals; Benzoates; Blood Pressure; Coronary Circulation; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Ethylenediamines; Female; Heart; Heart Rate; Hypoxia; Injections, Intravenous; Male; Vasodilator Agents | 1973 |
Changes in energy state and acid-base parameters of the rat brain during complete compression ischemia.
Topics: Acid-Base Equilibrium; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Amino Acids; Ammonia; Animals; Aspartic Acid; Brain; Carbohydrate Metabolism; Carbon Dioxide; Citrates; Disease Models, Animal; Glucose; Glutamates; Glutamine; Hydrogen-Ion Concentration; Intracranial Pressure; Ischemic Attack, Transient; Ketoglutaric Acids; Lactates; Malates; Nucleotidases; Oxidation-Reduction; Partial Pressure; Phosphocreatine; Pyruvates; Rats | 1974 |
Cerebral metabolic state following complete compression ischemia.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Amino Acids; Ammonia; Animals; Aspartic Acid; Blood Pressure; Carbohydrate Metabolism; Carbon Dioxide; Cerebral Cortex; Citric Acid Cycle; Disease Models, Animal; Electroencephalography; Glucose; Glutamine; Hydrogen-Ion Concentration; Intracranial Pressure; Ischemic Attack, Transient; Ketoglutaric Acids; Lactates; Malates; Mitochondria; Nucleotidases; Oxygen; Partial Pressure; Phosphocreatine; Pyruvates; Rats; Time Factors | 1974 |