adenine has been researched along with Vascular Calcification in 42 studies
Vascular Calcification: Deposition of calcium into the blood vessel structures. Excessive calcification of the vessels are associated with ATHEROSCLEROTIC PLAQUES formation particularly after MYOCARDIAL INFARCTION (see MONCKEBERG MEDIAL CALCIFIC SCLEROSIS) and chronic kidney diseases which in turn increase VASCULAR STIFFNESS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " As the prevalence of cardiac complications is higher in CKD, we tested the effectiveness of STS in a rat model of adenine-induced vascular calcification and subjected the heart to IR." | 7.88 | Sodium thiosulfate mediated cardioprotection against myocardial ischemia-reperfusion injury is defunct in rat heart with co-morbidity of vascular calcification. ( Kurian, GA; Ramachandran, K; Ravindran, S, 2018) |
| "This study investigated whether quercetin could alleviate vascular calcification in experimental chronic renal failure rats induced by adenine." | 7.85 | Quercetin Attenuates Vascular Calcification through Suppressed Oxidative Stress in Adenine-Induced Chronic Renal Failure Rats. ( Chang, XY; Cui, L; Hao, LR; Wang, XZ; Zhang, L; Zhou, XR; Zhu, D, 2017) |
| " Sodium thiosulfate (STS) due to its multiple properties such as antioxidant and calcium chelation has been reported to prevent vascular calcification in uremic rats, without mentioning its impact on cerebral function." | 7.81 | Sodium thiosulfate protects brain in rat model of adenine induced vascular calcification. ( Kurian, GA; Sriram, R; Subhash, N, 2015) |
| " The aim of the study was to assess the mechanisms involved by determining whether magnesium alone or combined with calcitriol treatments differentially impacts vascular calcification (VC) in male Sprague-Dawley rats with adenine-induced CKD." | 7.81 | Magnesium Modifies the Impact of Calcitriol Treatment on Vascular Calcification in Experimental Chronic Kidney Disease. ( Adams, MA; Barron, H; Holden, RM; Laverty, K; McCabe, KM; Svajger, B; Zelt, JG, 2015) |
| "The present study has shown that transplantation of metanephroi suppresses the progression of vascular calcification via a mechanism that is independent of calcium-phosphorus dynamics." | 7.78 | Metanephros transplantation inhibits the progression of vascular calcification in rats with adenine-induced renal failure. ( Hosoya, T; Kawamura, T; Matsumoto, K; Ohkido, I; Utsunomiya, Y; Yokoo, T; Yokote, S, 2012) |
| "Renal failure was assessed by plasma and urinary markers." | 5.43 | The renal mitochondrial dysfunction in patients with vascular calcification is prevented by sodium thiosulfate. ( Krishnaraj, P; Kurian, GA; Ravindran, S, 2016) |
| "But, treatment with diosgenin at a dose of 10, 20, and 40 mg/kg given via oral gavages causes reversion of all the above events in a dose-dependent manner." | 5.39 | Diosgenin attenuates vascular calcification in chronic renal failure rats. ( Arunagiri, P; Balamurugan, E; Barathkumar, TR; Manivannan, J; Raja, B; Sivasubramanian, J, 2013) |
| "Medial vascular calcification is highly prevalent in chronic kidney disease (CKD), and it is a risk factor for mortality." | 5.39 | Cardiovascular disease in an adenine-induced model of chronic kidney disease: the temporal link between vascular calcification and haemodynamic consequences. ( Adams, MA; Holden, RM; Pang, J; Shobeiri, N, 2013) |
| "Combined nutrients supplementation with omega-3 FA and MK-7 may be helpful for aortic VC prevention, reducing osteoclast activation and improving sarcopenia-related molecules in adenine and low-protein diet induced uremic rats." | 4.12 | Omega-3 fatty acid and menaquinone-7 combination are helpful for aortic calcification prevention, reducing osteoclast area of bone and Fox0 expression of muscle in uremic rats. ( An, WS; Jeong, EG; Jeong, YI; Kim, SE; Lee, SM; Rha, SH, 2022) |
| " As the prevalence of cardiac complications is higher in CKD, we tested the effectiveness of STS in a rat model of adenine-induced vascular calcification and subjected the heart to IR." | 3.88 | Sodium thiosulfate mediated cardioprotection against myocardial ischemia-reperfusion injury is defunct in rat heart with co-morbidity of vascular calcification. ( Kurian, GA; Ramachandran, K; Ravindran, S, 2018) |
| "This study investigated whether quercetin could alleviate vascular calcification in experimental chronic renal failure rats induced by adenine." | 3.85 | Quercetin Attenuates Vascular Calcification through Suppressed Oxidative Stress in Adenine-Induced Chronic Renal Failure Rats. ( Chang, XY; Cui, L; Hao, LR; Wang, XZ; Zhang, L; Zhou, XR; Zhu, D, 2017) |
| " Sodium thiosulfate (STS) due to its multiple properties such as antioxidant and calcium chelation has been reported to prevent vascular calcification in uremic rats, without mentioning its impact on cerebral function." | 3.81 | Sodium thiosulfate protects brain in rat model of adenine induced vascular calcification. ( Kurian, GA; Sriram, R; Subhash, N, 2015) |
| " The aim of the study was to assess the mechanisms involved by determining whether magnesium alone or combined with calcitriol treatments differentially impacts vascular calcification (VC) in male Sprague-Dawley rats with adenine-induced CKD." | 3.81 | Magnesium Modifies the Impact of Calcitriol Treatment on Vascular Calcification in Experimental Chronic Kidney Disease. ( Adams, MA; Barron, H; Holden, RM; Laverty, K; McCabe, KM; Svajger, B; Zelt, JG, 2015) |
| "Calcitriol and various analogs are commonly used to suppress secondary hyperparathyroidism in chronic kidney disease but may also exacerbate vascular calcification." | 3.80 | Role of local versus systemic vitamin D receptors in vascular calcification. ( Lomashvili, KA; O'Neill, WC; Wang, X, 2014) |
| "The present study has shown that transplantation of metanephroi suppresses the progression of vascular calcification via a mechanism that is independent of calcium-phosphorus dynamics." | 3.78 | Metanephros transplantation inhibits the progression of vascular calcification in rats with adenine-induced renal failure. ( Hosoya, T; Kawamura, T; Matsumoto, K; Ohkido, I; Utsunomiya, Y; Yokoo, T; Yokote, S, 2012) |
| "We hypothesized that investigation of disease progression at an early stage could provide novel insights in understanding AMC etiology." | 1.91 | Towards a better understanding of arterial calcification disease progression in CKD: investigation of early pathological alterations. ( D'Haese, P; De Meyer, G; Guns, PJ; Neutel, C; Opdebeeck, B; Van den Bergh, G; Verhulst, A, 2023) |
| "Cerebral ischemia reperfusion injury (CIR) is one of the clinical manifestations encountered during the management of stroke." | 1.91 | Evaluation of prophylactic efficacy of sodium thiosulfate in combating I/R injury in rat brain: exploring its efficiency further in vascular calcified brain slice model. ( Baskaran, K; Johnson, JT; Kurian, GA; Prem, PN; Ravindran, S, 2023) |
| "Marked vascular calcification was observed in adenine-fed animals, and immunohistochemical analysis showed increased expression of BMP2, RUNX2, vitamin D receptor (VDR), and Pit1 in aortic tissue." | 1.72 | Exogenous BMP7 administration attenuated vascular calcification and improved bone disorders in chronic uremic rats. ( Kuo, WH; Lee, CT; Lee, WC; Tain, YL; Wang, Y, 2022) |
| "Vascular calcification is a common finding in atherosclerosis and in patients with chronic kidney disease." | 1.51 | AT2 receptor stimulation inhibits phosphate-induced vascular calcification. ( Bai, HY; Higaki, A; Higaki, J; Horiuchi, M; Iwanami, J; Kan-No, H; Kukida, M; Min, LJ; Mogi, M; Okura, T; Shan, BS; Tsukuda, K; Yamauchi, T, 2019) |
| "Vascular calcification is highly prevalent in end-stage renal diseases and is predictive of cardiovascular events and mortality." | 1.51 | Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2. ( An, J; Huang, K; Li, Y; Liang, M; Tong, Q; Wang, C; Xu, W; Zhang, F, 2019) |
| "Metformin-treated rats did not develop hyperphosphatemia or hypocalcemia and this prevented the development of vascular calcification and inhibited the progression toward high bone turnover disease." | 1.48 | Metformin prevents the development of severe chronic kidney disease and its associated mineral and bone disorder. ( Brand, K; D'Haese, PC; De Broe, ME; De Maré, A; Gottwald-Hostalek, U; Kamel, S; Lalau, JD; Neven, E; Opdebeeck, B; Verhulst, A; Vervaet, B, 2018) |
| "Renal failure was assessed by plasma and urinary markers." | 1.43 | The renal mitochondrial dysfunction in patients with vascular calcification is prevented by sodium thiosulfate. ( Krishnaraj, P; Kurian, GA; Ravindran, S, 2016) |
| "Medial vascular calcification is a specific complication in chronic kidney disease (CKD) patients although its pathogenesis is poorly understood." | 1.40 | Suppressive effects of iron overloading on vascular calcification in uremic rats. ( Hamada, C; Seto, T; Tomino, Y, 2014) |
| "Adenine-induced chronic renal failure rat model was used to mimic the process of arterial medial calcification." | 1.40 | Overexpression of c1q/tumor necrosis factor-related protein-3 promotes phosphate-induced vascular smooth muscle cell calcification both in vivo and in vitro. ( Feng, H; Lei, H; Li, H; Li, L; Wang, C; Wang, JY; Wu, D; Wu, LL; Zhou, Y, 2014) |
| "Malnutrition and inflammation are also closely linked to an increased risk of cardiovascular death in CKD." | 1.40 | Phosphate overload directly induces systemic inflammation and malnutrition as well as vascular calcification in uremia. ( Kitazono, T; Masutani, K; Nakano, T; Noguchi, H; Ooboshi, H; Taniguchi, M; Tatsumoto, N; Tokumoto, M; Tsuruya, K; Yamada, S, 2014) |
| "But, treatment with diosgenin at a dose of 10, 20, and 40 mg/kg given via oral gavages causes reversion of all the above events in a dose-dependent manner." | 1.39 | Diosgenin attenuates vascular calcification in chronic renal failure rats. ( Arunagiri, P; Balamurugan, E; Barathkumar, TR; Manivannan, J; Raja, B; Sivasubramanian, J, 2013) |
| "After 1 week, rats with chronic renal failure were treated with vehicle, 375 or 750 mg/kg CaMg, or 750 mg/kg sevelamer by daily gavage for 5 weeks." | 1.39 | Effect of a magnesium-based phosphate binder on medial calcification in a rat model of uremia. ( Behets, GJ; D'Haese, PC; De Schutter, TM; Geryl, H; Gundlach, K; Neven, E; Passlick-Deetjen, J; Peter, ME; Steppan, S, 2013) |
| "Medial vascular calcification is highly prevalent in chronic kidney disease (CKD), and it is a risk factor for mortality." | 1.39 | Cardiovascular disease in an adenine-induced model of chronic kidney disease: the temporal link between vascular calcification and haemodynamic consequences. ( Adams, MA; Holden, RM; Pang, J; Shobeiri, N, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 32 (76.19) | 24.3611 |
| 2020's | 10 (23.81) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, CT | 1 |
| Kuo, WH | 1 |
| Tain, YL | 1 |
| Wang, Y | 1 |
| Lee, WC | 1 |
| Tölle, M | 1 |
| Henkel, C | 1 |
| Herrmann, J | 1 |
| Daniel, C | 1 |
| Babic, M | 1 |
| Xia, M | 1 |
| Schulz, AM | 1 |
| Amann, K | 1 |
| van der Giet, M | 1 |
| Schuchardt, M | 1 |
| Van den Bergh, G | 1 |
| Opdebeeck, B | 2 |
| Neutel, C | 2 |
| Guns, PJ | 1 |
| De Meyer, G | 1 |
| D'Haese, P | 1 |
| Verhulst, A | 3 |
| Sato, H | 3 |
| Goto, M | 3 |
| Nishimura, G | 3 |
| Morimoto, N | 3 |
| Tokushima, H | 3 |
| Horii, Y | 3 |
| Takahashi, N | 3 |
| Lee, SM | 1 |
| Jeong, EG | 1 |
| Jeong, YI | 1 |
| Rha, SH | 1 |
| Kim, SE | 1 |
| An, WS | 1 |
| Baskaran, K | 1 |
| Johnson, JT | 1 |
| Prem, PN | 1 |
| Ravindran, S | 3 |
| Kurian, GA | 4 |
| Yang, X | 1 |
| Liu, Y | 2 |
| Zhu, X | 1 |
| Chen, P | 1 |
| Xie, X | 1 |
| Xu, T | 1 |
| Zhang, X | 2 |
| Zhao, Y | 2 |
| Schantl, AE | 1 |
| Neven, E | 4 |
| Behets, GJ | 3 |
| D'Haese, PC | 4 |
| Maillard, M | 2 |
| Mordasini, D | 2 |
| Phan, O | 2 |
| Burnier, M | 2 |
| Spaggiari, D | 1 |
| Decosterd, LA | 1 |
| MacAskill, MG | 1 |
| Alcaide-Corral, CJ | 1 |
| Tavares, AAS | 1 |
| Newby, DE | 1 |
| Beindl, VC | 1 |
| Maj, R | 1 |
| Labarre, A | 1 |
| Hegde, C | 1 |
| Castagner, B | 1 |
| Ivarsson, ME | 1 |
| Leroux, JC | 1 |
| Lupo, MG | 1 |
| Biancorosso, N | 1 |
| Brilli, E | 1 |
| Tarantino, G | 1 |
| Adorni, MP | 1 |
| Vivian, G | 1 |
| Salvalaio, M | 1 |
| Dall'Acqua, S | 1 |
| Sut, S | 1 |
| Chen, H | 1 |
| Bressan, A | 1 |
| Faggin, E | 1 |
| Rattazzi, M | 1 |
| Ferri, N | 1 |
| Oh, YJ | 1 |
| Kim, H | 1 |
| Kim, AJ | 1 |
| Ro, H | 1 |
| Chang, JH | 1 |
| Lee, HH | 1 |
| Chung, W | 1 |
| Jun, HS | 1 |
| Jung, JY | 1 |
| Choi, SY | 1 |
| Ryu, HM | 1 |
| Oh, EJ | 1 |
| Choi, JY | 1 |
| Cho, JH | 1 |
| Kim, CD | 1 |
| Kim, YL | 1 |
| Park, SH | 1 |
| Chang, XY | 1 |
| Cui, L | 1 |
| Wang, XZ | 1 |
| Zhang, L | 2 |
| Zhu, D | 1 |
| Zhou, XR | 1 |
| Hao, LR | 1 |
| Yokote, S | 2 |
| Katsuoka, Y | 1 |
| Yamada, A | 1 |
| Ohkido, I | 2 |
| Yokoo, T | 2 |
| Ramachandran, K | 1 |
| Liao, L | 1 |
| Zhuang, X | 1 |
| Li, W | 1 |
| Su, Q | 1 |
| Zhao, J | 1 |
| Vervaet, B | 1 |
| Brand, K | 1 |
| Gottwald-Hostalek, U | 1 |
| De Maré, A | 1 |
| Lalau, JD | 1 |
| Kamel, S | 1 |
| De Broe, ME | 1 |
| Yao, Z | 1 |
| Xu, Y | 1 |
| Ma, W | 1 |
| Sun, XY | 1 |
| Jia, S | 1 |
| Zheng, Y | 1 |
| Liu, X | 1 |
| Fan, Y | 1 |
| Wang, C | 3 |
| Kukida, M | 1 |
| Mogi, M | 1 |
| Kan-No, H | 1 |
| Tsukuda, K | 1 |
| Bai, HY | 1 |
| Shan, BS | 1 |
| Yamauchi, T | 1 |
| Higaki, A | 1 |
| Min, LJ | 1 |
| Iwanami, J | 1 |
| Okura, T | 1 |
| Higaki, J | 1 |
| Horiuchi, M | 1 |
| Feng, H | 2 |
| Wang, JY | 2 |
| Yu, B | 1 |
| Cong, X | 1 |
| Zhang, WG | 1 |
| Li, L | 2 |
| Liu, LM | 1 |
| Zhou, Y | 2 |
| Zhang, CL | 1 |
| Gu, PL | 1 |
| Wu, LL | 2 |
| Clinkenbeard, EL | 1 |
| Noonan, ML | 1 |
| Thomas, JC | 1 |
| Ni, P | 1 |
| Hum, JM | 1 |
| Aref, M | 1 |
| Swallow, EA | 1 |
| Moe, SM | 1 |
| Allen, MR | 1 |
| White, KE | 1 |
| Xu, W | 1 |
| An, J | 1 |
| Liang, M | 1 |
| Li, Y | 2 |
| Zhang, F | 1 |
| Tong, Q | 1 |
| Huang, K | 1 |
| Manivannan, J | 1 |
| Barathkumar, TR | 1 |
| Sivasubramanian, J | 1 |
| Arunagiri, P | 1 |
| Raja, B | 1 |
| Balamurugan, E | 1 |
| De Schutter, TM | 2 |
| Geryl, H | 1 |
| Peter, ME | 1 |
| Steppan, S | 1 |
| Gundlach, K | 1 |
| Passlick-Deetjen, J | 1 |
| Peregaux, C | 1 |
| Stehle, JC | 1 |
| Funk, F | 1 |
| Lomashvili, KA | 1 |
| Wang, X | 3 |
| O'Neill, WC | 1 |
| Seto, T | 1 |
| Hamada, C | 1 |
| Tomino, Y | 1 |
| Wu, D | 1 |
| Lei, H | 1 |
| Li, H | 1 |
| Shimomura, A | 1 |
| Matsui, I | 1 |
| Hamano, T | 1 |
| Ishimoto, T | 1 |
| Katou, Y | 1 |
| Takehana, K | 1 |
| Inoue, K | 1 |
| Kusunoki, Y | 1 |
| Mori, D | 1 |
| Nakano, C | 1 |
| Obi, Y | 1 |
| Fujii, N | 1 |
| Takabatake, Y | 1 |
| Nakano, T | 2 |
| Tsubakihara, Y | 1 |
| Isaka, Y | 1 |
| Rakugi, H | 1 |
| Yamada, S | 3 |
| Tokumoto, M | 3 |
| Tatsumoto, N | 3 |
| Taniguchi, M | 1 |
| Noguchi, H | 3 |
| Masutani, K | 1 |
| Ooboshi, H | 2 |
| Tsuruya, K | 3 |
| Kitazono, T | 3 |
| Maio, MT | 1 |
| McCabe, KM | 3 |
| Pruss, CM | 1 |
| Pang, JJ | 2 |
| Laverty, K | 2 |
| Holden, RM | 4 |
| Adams, MA | 4 |
| Zhang, J | 1 |
| Zheng, B | 1 |
| Zhou, PP | 1 |
| Zhang, RN | 1 |
| He, M | 1 |
| Yang, Z | 1 |
| Wen, JK | 1 |
| Eriguchi, M | 1 |
| Torisu, K | 1 |
| Subhash, N | 1 |
| Sriram, R | 1 |
| Zelt, JG | 1 |
| Svajger, B | 1 |
| Barron, H | 1 |
| Gao, C | 1 |
| Fu, Y | 1 |
| Yu, F | 1 |
| Xu, SS | 1 |
| Xu, Q | 1 |
| Zhu, Y | 1 |
| Guan, Y | 2 |
| Kong, W | 2 |
| Krishnaraj, P | 1 |
| Persy, VP | 1 |
| Postnov, AA | 1 |
| De Clerck, NM | 1 |
| Matsumoto, K | 1 |
| Utsunomiya, Y | 1 |
| Kawamura, T | 1 |
| Hosoya, T | 1 |
| Shobeiri, N | 2 |
| Pang, J | 1 |
| Booth, SL | 1 |
| Fu, X | 1 |
| Dai, XY | 1 |
| Zhao, MM | 1 |
| Cai, Y | 1 |
| Guan, QC | 1 |
| Zhu, WG | 1 |
| Xu, MJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Spironolactone on the Progression of Coronary Calcification in Peritoneal Dialysis Patients[NCT03314493] | Phase 3 | 33 participants (Actual) | Interventional | 2014-11-07 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
42 other studies available for adenine and Vascular Calcification
| Article | Year |
|---|---|
Exogenous BMP7 administration attenuated vascular calcification and improved bone disorders in chronic uremic rats.
Topics: Adenine; Animals; Bone Morphogenetic Protein 7; Core Binding Factor Alpha 1 Subunit; Hyperphosphatem | 2022 |
Uremic mouse model to study vascular calcification and "inflamm-aging".
Topics: Adenine; Aging; Animals; Disease Models, Animal; Inflammation; Kidney Failure, Chronic; Mice; Rats; | 2022 |
Towards a better understanding of arterial calcification disease progression in CKD: investigation of early pathological alterations.
Topics: Adenine; Animals; Arteriosclerosis; Calcinosis; Calcium; Disease Progression; Male; Rats; Rats, Wist | 2023 |
Upacicalcet, a positive allosteric modulator of the calcium-sensing receptor, prevents vascular calcification and bone disorder in a rat adenine-induced secondary hyperparathyroidism model.
Topics: Adenine; Animals; Bone Diseases; Calcium; Hyperparathyroidism, Secondary; Hyperplasia; Parathyroid H | 2023 |
Upacicalcet, a positive allosteric modulator of the calcium-sensing receptor, prevents vascular calcification and bone disorder in a rat adenine-induced secondary hyperparathyroidism model.
Topics: Adenine; Animals; Bone Diseases; Calcium; Hyperparathyroidism, Secondary; Hyperplasia; Parathyroid H | 2023 |
Upacicalcet, a positive allosteric modulator of the calcium-sensing receptor, prevents vascular calcification and bone disorder in a rat adenine-induced secondary hyperparathyroidism model.
Topics: Adenine; Animals; Bone Diseases; Calcium; Hyperparathyroidism, Secondary; Hyperplasia; Parathyroid H | 2023 |
Upacicalcet, a positive allosteric modulator of the calcium-sensing receptor, prevents vascular calcification and bone disorder in a rat adenine-induced secondary hyperparathyroidism model.
Topics: Adenine; Animals; Bone Diseases; Calcium; Hyperparathyroidism, Secondary; Hyperplasia; Parathyroid H | 2023 |
Upacicalcet, a positive allosteric modulator of the calcium-sensing receptor, prevents vascular calcification and bone disorder in a rat adenine-induced secondary hyperparathyroidism model.
Topics: Adenine; Animals; Bone Diseases; Calcium; Hyperparathyroidism, Secondary; Hyperplasia; Parathyroid H | 2023 |
Upacicalcet, a positive allosteric modulator of the calcium-sensing receptor, prevents vascular calcification and bone disorder in a rat adenine-induced secondary hyperparathyroidism model.
Topics: Adenine; Animals; Bone Diseases; Calcium; Hyperparathyroidism, Secondary; Hyperplasia; Parathyroid H | 2023 |
Upacicalcet, a positive allosteric modulator of the calcium-sensing receptor, prevents vascular calcification and bone disorder in a rat adenine-induced secondary hyperparathyroidism model.
Topics: Adenine; Animals; Bone Diseases; Calcium; Hyperparathyroidism, Secondary; Hyperplasia; Parathyroid H | 2023 |
Upacicalcet, a positive allosteric modulator of the calcium-sensing receptor, prevents vascular calcification and bone disorder in a rat adenine-induced secondary hyperparathyroidism model.
Topics: Adenine; Animals; Bone Diseases; Calcium; Hyperparathyroidism, Secondary; Hyperplasia; Parathyroid H | 2023 |
Upacicalcet, a positive allosteric modulator of the calcium-sensing receptor, prevents vascular calcification and bone disorder in a rat adenine-induced secondary hyperparathyroidism model.
Topics: Adenine; Animals; Bone Diseases; Calcium; Hyperparathyroidism, Secondary; Hyperplasia; Parathyroid H | 2023 |
Omega-3 fatty acid and menaquinone-7 combination are helpful for aortic calcification prevention, reducing osteoclast area of bone and Fox0 expression of muscle in uremic rats.
Topics: Adenine; Animals; Aortic Diseases; Bone Diseases, Metabolic; Drug Therapy, Combination; Fatty Acids, | 2022 |
Evaluation of prophylactic efficacy of sodium thiosulfate in combating I/R injury in rat brain: exploring its efficiency further in vascular calcified brain slice model.
Topics: Adenine; Animals; Brain; Male; Rats; Rats, Wistar; Reperfusion Injury; Stroke; Vascular Calcificatio | 2023 |
Vascular, valvular and kidney calcification manifested in mouse models of adenine-induced chronic kidney disease.
Topics: Adenine; Animals; Calcinosis; Calcium; Humans; Kidney; Male; Mice; Mice, Inbred C57BL; Minerals; Nep | 2023 |
Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers.
Topics: 6-Phytase; Adenine; Animals; Cells, Cultured; Drug Evaluation, Preclinical; Dynamic Light Scattering | 2020 |
Cholesterol-Lowering Action of a Novel Nutraceutical Combination in Uremic Rats: Insights into the Molecular Mechanism in a Hepatoma Cell Line.
Topics: Acyl Coenzyme A; Adenine; Animals; Anticholesteremic Agents; Cell Line, Tumor; Cholesterol; Cysteine | 2020 |
Reduction of Secreted Frizzled-Related Protein 5 Drives Vascular Calcification through Wnt3a-Mediated Rho/ROCK/JNK Signaling in Chronic Kidney Disease.
Topics: Adaptor Proteins, Signal Transducing; Adenine; Adipokines; Animals; Cells, Cultured; Core Binding Fa | 2020 |
Dipeptidyl peptidase-4 inhibitor gemigliptin protects against vascular calcification in an experimental chronic kidney disease and vascular smooth muscle cells.
Topics: Adenine; Animals; Aorta, Abdominal; Calcium; Core Binding Factor Alpha 1 Subunit; Dipeptidyl-Peptida | 2017 |
Quercetin Attenuates Vascular Calcification through Suppressed Oxidative Stress in Adenine-Induced Chronic Renal Failure Rats.
Topics: Adenine; Alkaline Phosphatase; Animals; Aorta; Biomarkers; Calcium; Kidney; Kidney Failure, Chronic; | 2017 |
Effect of adipose-derived mesenchymal stem cell transplantation on vascular calcification in rats with adenine-induced kidney disease.
Topics: Adenine; Adipocytes; Animals; Calcium; Cell- and Tissue-Based Therapy; Kidney; Male; Mesenchymal Ste | 2017 |
Sodium thiosulfate mediated cardioprotection against myocardial ischemia-reperfusion injury is defunct in rat heart with co-morbidity of vascular calcification.
Topics: Adenine; Animals; Cardiotonic Agents; Heart; Male; Mitochondria; Myocardial Reperfusion Injury; Oxid | 2018 |
Polysaccharide from Fuzi protects against Ox‑LDL‑induced calcification of human vascular smooth muscle cells by increasing autophagic activity.
Topics: Adenine; Autophagy; Diterpenes; Drugs, Chinese Herbal; Humans; Lipoproteins, LDL; Muscle, Smooth, Va | 2018 |
Metformin prevents the development of severe chronic kidney disease and its associated mineral and bone disorder.
Topics: Adenine; Animals; Chronic Kidney Disease-Mineral and Bone Disorder; Disease Models, Animal; Humans; | 2018 |
Magnesium Citrate Protects Against Vascular Calcification in an Adenine-induced Chronic Renal Failure Rat Model.
Topics: Actins; Adenine; Alkaline Phosphatase; Animals; Aorta; Aortic Diseases; Calcium; Cardiovascular Agen | 2018 |
AT2 receptor stimulation inhibits phosphate-induced vascular calcification.
Topics: Adenine; Animals; Aorta, Thoracic; Aortic Diseases; Cells, Cultured; Disease Models, Animal; Humans; | 2019 |
Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α Inhibits Vascular Calcification Through Sirtuin 3-Mediated Reduction of Mitochondrial Oxidative Stress.
Topics: Adenine; Aged; Aged, 80 and over; Animals; Aorta, Abdominal; Cells, Cultured; Disease Models, Animal | 2019 |
Increased FGF23 protects against detrimental cardio-renal consequences during elevated blood phosphate in CKD.
Topics: Adenine; Animals; Bone and Bones; Cardio-Renal Syndrome; Disease Models, Animal; Echocardiography; F | 2019 |
Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2.
Topics: Adenine; Animals; Cells, Cultured; Core Binding Factor Alpha 1 Subunit; Disease Models, Animal; Gene | 2019 |
Diosgenin attenuates vascular calcification in chronic renal failure rats.
Topics: Adenine; Alkaline Phosphatase; Animals; Anti-Inflammatory Agents; Aorta; Biomarkers; Calcium; Catala | 2013 |
Effect of a magnesium-based phosphate binder on medial calcification in a rat model of uremia.
Topics: Acetates; Adenine; Animals; Aortic Diseases; Bone Morphogenetic Protein 2; Calcium; Calcium Compound | 2013 |
PA21, a new iron-based noncalcium phosphate binder, prevents vascular calcification in chronic renal failure rats.
Topics: Adenine; Animals; Aorta; Blood Pressure; Calcium; Calcium Carbonate; Ferric Compounds; Fibroblast Gr | 2013 |
Role of local versus systemic vitamin D receptors in vascular calcification.
Topics: Adenine; Animals; Aorta; Calcitriol; Disease Models, Animal; Female; Genetic Markers; Male; Mice; Mi | 2014 |
Suppressive effects of iron overloading on vascular calcification in uremic rats.
Topics: Adenine; Animals; Aorta, Thoracic; Core Binding Factor Alpha 1 Subunit; Creatinine; DNA, Single-Stra | 2014 |
Overexpression of c1q/tumor necrosis factor-related protein-3 promotes phosphate-induced vascular smooth muscle cell calcification both in vivo and in vitro.
Topics: Actins; Adenine; Alkaline Phosphatase; Animals; Aorta, Abdominal; Aortic Diseases; Bone Morphogeneti | 2014 |
Dietary L-lysine prevents arterial calcification in adenine-induced uremic rats.
Topics: Adenine; Alanine; Animals; Apoptosis; Arginine; Calcium; Calcium Phosphates; Cells, Cultured; Chemic | 2014 |
Phosphate overload directly induces systemic inflammation and malnutrition as well as vascular calcification in uremia.
Topics: Acute-Phase Proteins; Adenine; Animals; Blood Pressure; Cells, Cultured; Disease Models, Animal; Dos | 2014 |
Calcification of the internal pudendal artery and development of erectile dysfunction in adenine-induced chronic kidney disease: a sentinel of systemic vascular changes.
Topics: Adenine; Animals; Arteries; Calcium; Erectile Dysfunction; Male; Pelvis; Penile Erection; Penis; Pho | 2014 |
Vascular calcification is coupled with phenotypic conversion of vascular smooth muscle cells through Klf5-mediated transactivation of the Runx2 promoter.
Topics: Adenine; Animals; Blotting, Western; Calcinosis; Cells, Cultured; Core Binding Factor Alpha 1 Subuni | 2014 |
Phosphate binders prevent phosphate-induced cellular senescence of vascular smooth muscle cells and vascular calcification in a modified, adenine-based uremic rat model.
Topics: Adenine; Animal Feed; Animals; Calcinosis; Calcium Carbonate; Cellular Senescence; Disease Models, A | 2015 |
Spironolactone ameliorates arterial medial calcification in uremic rats: the role of mineralocorticoid receptor signaling in vascular calcification.
Topics: Adenine; Animals; Aorta, Abdominal; Aortic Diseases; Apoptosis; Biomarkers; Disease Models, Animal; | 2015 |
Sodium thiosulfate protects brain in rat model of adenine induced vascular calcification.
Topics: Adenine; Animals; Antioxidants; Brain; Catalase; Disease Models, Animal; Glutathione Peroxidase; Kid | 2015 |
Magnesium Modifies the Impact of Calcitriol Treatment on Vascular Calcification in Experimental Chronic Kidney Disease.
Topics: Adenine; Animals; Aorta, Abdominal; Calcitriol; Calcium; Calcium Channel Agonists; Carotid Arteries; | 2015 |
Microsomal Prostaglandin E Synthase-1-Derived PGE2 Inhibits Vascular Smooth Muscle Cell Calcification.
Topics: Adenine; Animals; Aorta, Abdominal; Aorta, Thoracic; Aortic Diseases; Calcitriol; Cells, Cultured; C | 2016 |
The renal mitochondrial dysfunction in patients with vascular calcification is prevented by sodium thiosulfate.
Topics: Adenine; Animals; Antioxidants; Aorta; Apoptosis; Catalase; DNA Fragmentation; Glutathione; Glutathi | 2016 |
Vascular calcification is associated with cortical bone loss in chronic renal failure rats with and without ovariectomy: the calcification paradox.
Topics: Adenine; Animals; Aorta; Body Weight; Bone and Bones; Calcinosis; Disease Progression; Female; Kidne | 2011 |
Metanephros transplantation inhibits the progression of vascular calcification in rats with adenine-induced renal failure.
Topics: 25-Hydroxyvitamin D3 1-alpha-Hydroxylase; Adenine; Animals; Aorta, Thoracic; Calcitriol; Calcium; Cr | 2012 |
Cardiovascular disease in an adenine-induced model of chronic kidney disease: the temporal link between vascular calcification and haemodynamic consequences.
Topics: Adenine; Animals; Blood Pressure; Cardiovascular Diseases; Disease Models, Animal; Hemodynamics; Mal | 2013 |
Dietary vitamin K and therapeutic warfarin alter the susceptibility to vascular calcification in experimental chronic kidney disease.
Topics: Adenine; Animals; Anticoagulants; Arteries; Biomarkers; Blood Pressure; Dietary Supplements; Disease | 2013 |
Phosphate-induced autophagy counteracts vascular calcification by reducing matrix vesicle release.
Topics: Adenine; Alkaline Phosphatase; Amino Acid Chloromethyl Ketones; Animals; Antioxidants; Autophagy; Au | 2013 |