adenine has been researched along with Trypanosomiasis, African in 5 studies
Trypanosomiasis, African: A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces African sleeping sickness. Nagana is a rapidly fatal trypanosomiasis of horses and other animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Novel methods for treatment of African trypanosomiasis, caused by infection with Trypanosoma brucei are needed." | 1.39 | Structure-activity relationships of synthetic cordycepin analogues as experimental therapeutics for African trypanosomiasis. ( de Koning, HP; Eze, AA; Gustavsson, AL; Hammarström, LG; Lundbäck, T; Olivera, GC; Rottenberg, ME; Sjöberg, B; Svensson, R; Vodnala, SK; Yeheskieli, E, 2013) |
| "During the first stage of human African trypanosomiasis (HAT), Trypanosoma brucei gambiense is found mainly in the blood, and pentamidine treatment is used." | 1.35 | Pentamidine movement across the murine blood-brain and blood-cerebrospinal fluid barriers: effect of trypanosome infection, combination therapy, P-glycoprotein, and multidrug resistance-associated protein. ( De Koning, HP; Dogruel, M; Rodgers, J; Sanderson, L; Thomas, SA, 2009) |
| "African sleeping sickness is caused by Trypanosoma brucei." | 1.35 | Adenosine kinase mediates high affinity adenosine salvage in Trypanosoma brucei. ( Fijolek, A; Hofer, A; Mäser, P; Mosimann, M; Rofougaran, R; Vodnala, M, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vodnala, SK | 1 |
| Lundbäck, T | 1 |
| Yeheskieli, E | 1 |
| Sjöberg, B | 1 |
| Gustavsson, AL | 1 |
| Svensson, R | 1 |
| Olivera, GC | 1 |
| Eze, AA | 1 |
| de Koning, HP | 3 |
| Hammarström, LG | 1 |
| Rottenberg, ME | 1 |
| Ranjbarian, F | 1 |
| Vodnala, M | 2 |
| Alzahrani, KJH | 1 |
| Ebiloma, GU | 1 |
| Hofer, A | 2 |
| Sanderson, L | 1 |
| Dogruel, M | 1 |
| Rodgers, J | 1 |
| Thomas, SA | 1 |
| Fijolek, A | 1 |
| Rofougaran, R | 1 |
| Mosimann, M | 1 |
| Mäser, P | 1 |
| Kaminsky, R | 1 |
| Zweygarth, E | 1 |
| De Clercq, E | 1 |
5 other studies available for adenine and Trypanosomiasis, African
| Article | Year |
|---|---|
Structure-activity relationships of synthetic cordycepin analogues as experimental therapeutics for African trypanosomiasis.
Topics: Animals; Cell Survival; Cells, Cultured; Deoxyadenosines; Dose-Response Relationship, Drug; Humans; | 2013 |
9-(2'-Deoxy-2'-Fluoro-β-d-Arabinofuranosyl) Adenine Is a Potent Antitrypanosomal Adenosine Analogue That Circumvents Transport-Related Drug Resistance.
Topics: Adenine; Adenosine Kinase; Animals; Antimetabolites; Drug Resistance; Mice; Purine-Nucleoside Phosph | 2017 |
Pentamidine movement across the murine blood-brain and blood-cerebrospinal fluid barriers: effect of trypanosome infection, combination therapy, P-glycoprotein, and multidrug resistance-associated protein.
Topics: Adenine; Adenosine; Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Bl | 2009 |
Adenosine kinase mediates high affinity adenosine salvage in Trypanosoma brucei.
Topics: Adenine; Adenosine Kinase; Animals; Antimetabolites; Catalysis; Guanosine Triphosphate; Humans; Leis | 2008 |
Antitrypanosomal activity of phosphonylmethoxyalkylpurines.
Topics: Adenine; Animals; Cidofovir; Cytosine; Female; Mice; Mice, Inbred BALB C; Organophosphonates; Organo | 1994 |