adenine has been researched along with Seizures in 14 studies
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In order to further evaluate the role of adenosine in seizure activity, we monitored adenosine and its major biochemical metabolites inosine, xanthine, and hypoxanthine in the dorsal hippocampus by in vivo microdialysis before and during the induction of generalized seizures." | 7.70 | Evidence for increased dorsal hippocampal adenosine release and metabolism during pharmacologically induced seizures in rats. ( Aden, U; Berman, RF; Fredholm, BB; O'Connor, WT, 2000) |
| "Adenosine is a well-known endogenous modulator of neuronal excitability with anticonvulsant properties." | 5.42 | Role of adenosine signaling on pentylenetetrazole-induced seizures in zebrafish. ( Bogo, MR; Bonan, CD; Capiotti, KM; da Costa Schaefer, I; Da Silva, RS; Frantz, JZ; Kist, LW; Menezes, FP; Siebel, AM, 2015) |
| "The novel putative anticonvulsant drug 1-[2,6-difluorophenyl)-methyl]-1H-1,2,3-triazolo[4,5-c]) pyridine-4-amine monohydrochloride (BW534U87) effectively reduced seizures induced in rodents by threshold maximal and supramaximal electroshock, electrical kindling, pentylenetetrazole (PTZ) infusion and by vestibular stimulation in the genetically seizure-prone epilepsy-like (EL) mouse." | 3.71 | Broad spectrum anticonvulsant activity of BW534U87: possible role of an adenosine-dependent mechanism. ( Brackenborough, KT; Duffy, C; Hagan, RM; Jones, SA; Morgan, PF; Pratt, GD; Sargent, RS; Southam, E; Stratton, SC, 2002) |
| " In order to further evaluate the role of adenosine in seizure activity, we monitored adenosine and its major biochemical metabolites inosine, xanthine, and hypoxanthine in the dorsal hippocampus by in vivo microdialysis before and during the induction of generalized seizures." | 3.70 | Evidence for increased dorsal hippocampal adenosine release and metabolism during pharmacologically induced seizures in rats. ( Aden, U; Berman, RF; Fredholm, BB; O'Connor, WT, 2000) |
| "Epilepsy affects all ages, races, genders, and socioeconomic groups." | 1.56 | PI3K isoform-selective inhibition in neuron-specific PTEN-deficient mice rescues molecular defects and reduces epilepsy-associated phenotypes. ( Danzer, SC; Gross, C; MacLeod, MC; Tiwari, D; White, AR, 2020) |
| "KD alleviated seizure severity, decreased the number of Fluoro-jade B (FJB)-positive cells in the hippocampus of kindled rats." | 1.48 | Ketogenic diet attenuates neuronal injury via autophagy and mitochondrial pathways in pentylenetetrazol-kindled seizures. ( Hou, Q; Jia, MM; Jiang, Y; Lu, YQ; Qiu, T; Wang, BH; Wang, XH; Zhang, ZX, 2018) |
| "Adenosine is a well-known endogenous modulator of neuronal excitability with anticonvulsant properties." | 1.42 | Role of adenosine signaling on pentylenetetrazole-induced seizures in zebrafish. ( Bogo, MR; Bonan, CD; Capiotti, KM; da Costa Schaefer, I; Da Silva, RS; Frantz, JZ; Kist, LW; Menezes, FP; Siebel, AM, 2015) |
| "All patients had convulsions or loss of consciousness resulting from hypoglycemia at less than 1 year of age." | 1.31 | Novel missense mutations in the glutamate dehydrogenase gene in the congenital hyperinsulinism-hyperammonemia syndrome. ( Hayashi, Y; Kato, H; Miki, Y; Ohura, T; Taki, T; Yanagisawa, M, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 5 (35.71) | 29.6817 |
| 2010's | 6 (42.86) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| White, AR | 1 |
| Tiwari, D | 1 |
| MacLeod, MC | 1 |
| Danzer, SC | 1 |
| Gross, C | 1 |
| Wang, BH | 1 |
| Hou, Q | 1 |
| Lu, YQ | 1 |
| Jia, MM | 1 |
| Qiu, T | 1 |
| Wang, XH | 1 |
| Zhang, ZX | 1 |
| Jiang, Y | 1 |
| Hall, J | 1 |
| Frenguelli, BG | 1 |
| Siebel, AM | 1 |
| Menezes, FP | 1 |
| Capiotti, KM | 1 |
| Kist, LW | 1 |
| da Costa Schaefer, I | 1 |
| Frantz, JZ | 1 |
| Bogo, MR | 1 |
| Da Silva, RS | 1 |
| Bonan, CD | 1 |
| Kommajosyula, SP | 1 |
| Randall, ME | 1 |
| Faingold, CL | 1 |
| Shen, HY | 1 |
| Li, T | 1 |
| Boison, D | 1 |
| Ni, H | 1 |
| Feng, X | 1 |
| Gong, Y | 1 |
| Tao, LY | 1 |
| Wu, XR | 1 |
| Southam, E | 1 |
| Stratton, SC | 1 |
| Sargent, RS | 1 |
| Brackenborough, KT | 1 |
| Duffy, C | 1 |
| Hagan, RM | 1 |
| Pratt, GD | 1 |
| Jones, SA | 1 |
| Morgan, PF | 1 |
| Akula, KK | 1 |
| Dhir, A | 1 |
| Kulkarni, SK | 1 |
| Mehling, M | 1 |
| Drechsler, H | 1 |
| Kuhle, J | 1 |
| Hardmeier, M | 1 |
| Doerries, R | 1 |
| Ruegg, S | 1 |
| Gass, A | 1 |
| Schmidt, H | 1 |
| Siems, WG | 1 |
| Grune, T | 1 |
| Grauel, EL | 1 |
| Miki, Y | 1 |
| Taki, T | 1 |
| Ohura, T | 1 |
| Kato, H | 1 |
| Yanagisawa, M | 1 |
| Hayashi, Y | 1 |
| Berman, RF | 1 |
| Fredholm, BB | 1 |
| Aden, U | 1 |
| O'Connor, WT | 1 |
| Lewin, E | 1 |
14 other studies available for adenine and Seizures
| Article | Year |
|---|---|
PI3K isoform-selective inhibition in neuron-specific PTEN-deficient mice rescues molecular defects and reduces epilepsy-associated phenotypes.
Topics: Adenine; Animals; Cerebral Cortex; Class I Phosphatidylinositol 3-Kinases; Epilepsy; Female; Hippoca | 2020 |
Ketogenic diet attenuates neuronal injury via autophagy and mitochondrial pathways in pentylenetetrazol-kindled seizures.
Topics: Adenine; Animals; Apoptosis; Autophagy; Caspase 3; Cytochromes c; Diet, Ketogenic; Epilepsy; Hippoca | 2018 |
The combination of ribose and adenine promotes adenosine release and attenuates the intensity and frequency of epileptiform activity in hippocampal slices: Evidence for the rapid depletion of cellular ATP during electrographic seizures.
Topics: Adenine; Adenosine; Adenosine Triphosphate; Animals; Creatine; Electrophysiological Phenomena; Epile | 2018 |
Role of adenosine signaling on pentylenetetrazole-induced seizures in zebrafish.
Topics: Adenine; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine Diphosphate; Animals; Benzyl Compou | 2015 |
Inhibition of adenosine metabolism induces changes in post-ictal depression, respiration, and mortality in genetically epilepsy prone rats.
Topics: Adenine; Adenosine; Animals; Blood Gas Analysis; Brugada Syndrome; Disease Models, Animal; Enzyme In | 2016 |
A novel mouse model for sudden unexpected death in epilepsy (SUDEP): role of impaired adenosine clearance.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Caffeine; Cause of De | 2010 |
Acute phase expression pattern of ZnTs, LC3, and beclin-1 in rat Hippocampus and its regulation by 3-methyladenine following recurrent neonatal seizures.
Topics: Adenine; Animals; Blotting, Western; Cation Transport Proteins; Hippocampus; Microtubule-Associated | 2011 |
Broad spectrum anticonvulsant activity of BW534U87: possible role of an adenosine-dependent mechanism.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Amygdala; Animals; Anticonv | 2002 |
Rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor increases pentylenetetrazol seizure threshold in mice: possible involvement of adenosinergic mechanism.
Topics: Adenine; Adenosine; Analysis of Variance; Animals; Cyclooxygenase 2 Inhibitors; Disease Models, Anim | 2008 |
Adaptation of antiretroviral therapy in human immunodeficiency virus infection with central nervous system involvement.
Topics: Adenine; Adult; AIDS Dementia Complex; Alkynes; Anti-HIV Agents; Anticonvulsants; Antiretroviral The | 2008 |
Concentration of purine compounds in the cerebrospinal fluid of infants suffering from sepsis, convulsions and hydrocephalus.
Topics: Adenine; Bacterial Infections; Chromatography, High Pressure Liquid; Humans; Hydrocephalus; Hypoxant | 1995 |
Novel missense mutations in the glutamate dehydrogenase gene in the congenital hyperinsulinism-hyperammonemia syndrome.
Topics: Adenine; Ammonia; Codon; Cytosine; Female; Glutamate Dehydrogenase; Guanine; Heterozygote; Humans; H | 2000 |
Evidence for increased dorsal hippocampal adenosine release and metabolism during pharmacologically induced seizures in rats.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Bicuculline; Convulsants; Disease Model | 2000 |
Endogenously released adenine derivatives: a possible role in epileptogenesis.
Topics: Adenine; Adenosine; Animals; Hypoxanthines; Inosine; Rats; Seizures | 1976 |