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adenine and Retroviridae Infections

adenine has been researched along with Retroviridae Infections in 16 studies

Retroviridae Infections: Virus diseases caused by the RETROVIRIDAE.

Research Excerpts

ExcerptRelevanceReference
" Variables that can be experimentally manipulated to address specific questions relevant to postexposure prophylaxis (PEP) include timing of initiation of treatment, duration of treatment, dosing regimen, virus strain, and virus inoculum."2.40Animal studies of prophylaxis. ( Black, RJ, 1997)
"In summary, the establishment of XMRV infection in patients may be dependent on infection of A3G/A3F-deficient cells, and cells expressing low levels of A3G/A3F, such as prostate cancer cells, may be ideal producers of infectious XMRV."1.36Inhibition of xenotropic murine leukemia virus-related virus by APOBEC3 proteins and antiviral drugs. ( Burdick, R; Chaipan, C; Delviks-Frankenberry, KA; Hu, WS; Paprotka, T; Pathak, VK; Venkatachari, NJ, 2010)
" Pharmacokinetic experiments in mice showed that the oral bioavailabilities of PMEA following oral gavage of Bis-PMEA or PMEA (at a dose equivalent to 28 mg of PMEA/kg) were 50."1.31Pharmacokinetic and antiretroviral activity in mice of oral [P(1),P(2)-bis[2-(adenin-9-yl)ethoxymethyl]phosphonate], a prodrug of 9-(2-phosphonylmethoxyethyl)adenine. ( Cappellacci, L; Casabianca, A; Celeste, AG; Cerasi, A; Chiarantini, L; Dominici, S; Franchetti, P; Grifantini, M; Magnani, M; Rossi, L; Serafini, S, 2002)
" Within < or = 2 weeks of treatment, PMPA in both dosing regimens reduced SIV levels by >99% in the plasma or peripheral blood mononuclear cells; in some macaques SIV levels were reduced to below the lower quantitation limit."1.30Effects of (R)-9-(2-phosphonylmethoxypropyl)adenine monotherapy on chronic SIV infection in macaques. ( Beck, TW; Bischofberger, N; Dailey, PJ; Follis, KE; Sabo, A; Tsai, CC, 1997)
" Pharmacokinetic studies with mice showed that the oral bioavailability of bis(POC)-PMPA (calculated from the curves of the concentration of free PMPA in plasma) was 20%."1.30Antiretroviral efficacy and pharmacokinetics of oral bis(isopropyloxycarbonyloxymethyl)-9-(2-phosphonylmethoxypropyl)adenine in mice. ( Annaert, P; Arimilli, MN; Augustijns, P; Bischofberger, N; De Clercq, E; Kim, CU; Naesens, L; Van den Mooter, G, 1998)
" Pharmacokinetic experiments with mice showed that the oral bioavailabilities of PMEA following oral gavage of bis(POM)-PMEA, diphenyl-PMEA, or PMEA (at a dose equivalent to 50 mg of PMEA per kg) were 53,3, and 16%, respectively."1.29Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine. ( Balzarini, J; Bischofberger, N; De Clercq, E; Naesens, L, 1996)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's9 (56.25)18.2507
2000's5 (31.25)29.6817
2010's2 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Paprotka, T1
Venkatachari, NJ1
Chaipan, C1
Burdick, R1
Delviks-Frankenberry, KA1
Hu, WS1
Pathak, VK1
Greggs, WM1
Clouser, CL1
Patterson, SE1
Mansky, LM1
Rossi, L1
Dominici, S1
Serafini, S1
Casabianca, A1
Cerasi, A1
Chiarantini, L1
Celeste, AG1
Cappellacci, L1
Franchetti, P1
Grifantini, M1
Magnani, M1
De Clercq, E10
Balzarini, J5
Schols, D1
Van Laethem, K1
Hocková, D1
Masojidkova, M1
Holý, A1
Naesens, L3
Bischofberger, N3
Vahlenkamp, T1
Egberink, H2
Hartmann, K1
Witvrouw, M1
Pannecouque, C1
Casara, P1
Navé, JF1
Tsai, CC1
Follis, KE1
Beck, TW1
Sabo, A1
Dailey, PJ1
Augustijns, P1
Annaert, P1
Van den Mooter, G1
Arimilli, MN1
Kim, CU1
Black, RJ1
Hakimelahi, GH1
Ly, TW1
Moosavi-Movahedi, AA1
Jain, ML1
Zakerinia, M1
Davari, H1
Mei, HC1
Sambaiah, T1
Moshfegh, AA1
Hakimelahi, S1
Borst, M1
Niphuis, H1
Neu, H1
Schellekens, H1
Horzinek, M1
Koolen, M1

Reviews

6 reviews available for adenine and Retroviridae Infections

ArticleYear
Clinical potential of the acyclic nucleoside phosphonates cidofovir, adefovir, and tenofovir in treatment of DNA virus and retrovirus infections.
    Clinical microbiology reviews, 2003, Volume: 16, Issue:4

    Topics: Adenine; Animals; Cidofovir; Cytosine; DNA Virus Infections; DNA Viruses; Humans; Organophosphonates

2003
Potential of acyclic nucleoside phosphonates in the treatment of DNA virus and retrovirus infections.
    Expert review of anti-infective therapy, 2003, Volume: 1, Issue:1

    Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; Disease Models, Animal; DNA Virus Infection

2003
The potential of acyclic nucleoside phosphonates as broad-spectrum antiviral agents.
    Postepy biochemii, 1995, Volume: 41, Issue:5 Suppl

    Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; Herpesviridae Infections; Humans; Organopho

1995
Acyclic nucleoside phosphonates in the chemotherapy of DNA virus and retrovirus infections.
    Intervirology, 1997, Volume: 40, Issue:5-6

    Topics: Adenine; Animals; Anti-HIV Agents; Antiviral Agents; Cidofovir; Cytosine; DNA Virus Infections; Huma

1997
Animal studies of prophylaxis.
    The American journal of medicine, 1997, May-19, Volume: 102, Issue:5B

    Topics: Adenine; Animals; Anti-HIV Agents; Disease Models, Animal; Drug Administration Schedule; Interferon-

1997
Therapeutic potential of phosphonylmethoxyalkylpurines and -pyrimidines as antiviral agents.
    Drugs under experimental and clinical research, 1990, Volume: 16, Issue:7

    Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; HIV Infections; Humans; Organophosphonates;

1990

Other Studies

10 other studies available for adenine and Retroviridae Infections

ArticleYear
Inhibition of xenotropic murine leukemia virus-related virus by APOBEC3 proteins and antiviral drugs.
    Journal of virology, 2010, Volume: 84, Issue:11

    Topics: Adenine; Animals; Antiviral Agents; Cell Line, Tumor; Cytidine Deaminase; Gammaretrovirus; Humans; L

2010
Discovery of drugs that possess activity against feline leukemia virus.
    The Journal of general virology, 2012, Volume: 93, Issue:Pt 4

    Topics: Adenine; Animals; Antiviral Agents; Azacitidine; Cat Diseases; Cats; Decitabine; Deoxycytidine; Dose

2012
Pharmacokinetic and antiretroviral activity in mice of oral [P(1),P(2)-bis[2-(adenin-9-yl)ethoxymethyl]phosphonate], a prodrug of 9-(2-phosphonylmethoxyethyl)adenine.
    The Journal of antimicrobial chemotherapy, 2002, Volume: 50, Issue:3

    Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Biological Availability; Blood Cell Count;

2002
Pronounced in vitro and in vivo antiretroviral activity of 5-substituted 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy] pyrimidines.
    The Journal of antimicrobial chemotherapy, 2007, Volume: 59, Issue:1

    Topics: Adenine; Animals; Anti-HIV Agents; Cell Line; Drug Resistance, Viral; HIV-1; HIV-2; Humans; Mice; Mo

2007
Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine.
    Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:1

    Topics: Adenine; Animals; Anti-HIV Agents; Antiviral Agents; Female; Friend murine leukemia virus; Humans; I

1996
Antiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected newborn NM
    Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:3

    Topics: Adenine; Animals; Animals, Newborn; Antiviral Agents; Cell Line; Fibroblasts; Guanine; Humans; Mice;

1997
Effects of (R)-9-(2-phosphonylmethoxypropyl)adenine monotherapy on chronic SIV infection in macaques.
    AIDS research and human retroviruses, 1997, May-20, Volume: 13, Issue:8

    Topics: Adenine; Animals; Antiviral Agents; CD4-Positive T-Lymphocytes; Drug Evaluation; Lymphocyte Count; L

1997
Antiretroviral efficacy and pharmacokinetics of oral bis(isopropyloxycarbonyloxymethyl)-9-(2-phosphonylmethoxypropyl)adenine in mice.
    Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:7

    Topics: Adenine; Administration, Oral; Animals; Anti-HIV Agents; Biological Transport; Caco-2 Cells; Female;

1998
Design, synthesis, and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses.
    Journal of medicinal chemistry, 2001, Oct-25, Volume: 44, Issue:22

    Topics: Adenine; Adenine Nucleotides; Adenosine Deaminase Inhibitors; Animals; Antineoplastic Agents; Antivi

2001
Suppression of feline immunodeficiency virus infection in vivo by 9-(2-phosphonomethoxyethyl)adenine.
    Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:8

    Topics: Adenine; Animals; Antiviral Agents; Cats; Cell Line; HIV; Immunologic Deficiency Syndromes; Opportun

1990