adenine has been researched along with Renal Insufficiency, Chronic in 208 studies
Renal Insufficiency, Chronic: Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, the hypothesis that RBM supplementation is able to protect against kidney dysfunction and hypertension was tested by using an adenine-induced CKD model." | 8.31 | Dietary Resveratrol Butyrate Monoester Supplement Improves Hypertension and Kidney Dysfunction in a Young Rat Chronic Kidney Disease Model. ( Chang, CI; Chang-Chien, GP; Hou, CY; Hsu, CN; Lin, S; Tain, YL, 2023) |
| "Colchicine inhibited tubulin polymerization and caspase-1 activation and attenuated kidney inflammation and fibrosis in a mouse model of adenine-induced KI." | 8.31 | Beneficiary Effects of Colchicine on Inflammation and Fibrosis in a Mouse Model of Kidney Injury. ( Arazi, E; Landau, D; Segev, Y; Shukri, N; Tobar, A, 2023) |
| "We investigated antifibrotic effects of capsaicin in two mouse renal fibrosis models as follows: C57BL/6J mice were subjected to unilateral ureteral obstruction (UUO) and fed with an adenine-rich diet." | 8.12 | Capsaicin ameliorates renal fibrosis by inhibiting TGF-β1-Smad2/3 signaling. ( Li, X; Liu, Z; Meng, D; Tang, S; Wang, H; Wang, W; Wu, Y; Xia, W; Zhang, J; Zhou, X, 2022) |
| "Tenofovir alafenamide (TAF) may be preferable to other nucleos(t)ide analogues (NA) regarding outcomes against chronic hepatitis B virus (HBV) infection." | 8.12 | Switching to tenofovir alafenamide for nucleos(t)ide analogue-experienced patients with chronic hepatitis B: week 144 results from a real-world, multi-centre cohort study. ( Amagase, H; Azuma, K; Dohmen, K; Furusyo, N; Hayashi, J; Ichiki, Y; Kajiwara, E; Kato, M; Kawano, A; Koyanagi, T; Kuniyoshi, M; Morita, C; Nakamuta, M; Nomura, H; Ogawa, E; Ooho, A; Satoh, T; Shimoda, S; Sugimoto, R; Takahashi, K; Yamashita, N, 2022) |
| "Although tenofovir alafenamide (TAF) and besifovir dipivoxil maleate (BSV) are potent antiviral agents in the treatment of chronic hepatitis B (CHB) infection, their renal safety profiles have not been previously compared." | 8.12 | Similar risk of kidney function decline between tenofovir alafenamide and besifovir dipivoxil maleate in chronic hepatitis B. ( Ahn, SH; Jung, CY; Kim, BS; Kim, HW; Kim, SU; Lee, HW; Lee, JI, 2022) |
| " The characterizations were analyzed by physicochemical methods, and the renoprotections were processed in adenine-induced chronic kidney diseases (CKD) models of mice." | 8.02 | Renoprotective effects of enzyme-hydrolyzed polysaccharides from Auricularia polytricha on adenine-induced chronic kidney diseases in mice. ( Cui, W; Jia, L; Li, J; Pang, H; Song, X; Zhang, J, 2021) |
| "Renal toxicity of adefovir disoproxil (ADV) and tenofovir disoproxil fumarate (TDF) is a significant concern in chronic hepatitis B (CHB) patients." | 7.91 | In Vitro and In Vivo Renoprotective Effects of Telbivudine in Chronic Hepatitis B Patients Receiving Nucleotide Analogue. ( Chan, TM; Fung, J; Lai, CL; Liu, SH; Mak, LY; Seto, WK; Wong, DK; Yap, DY; Yuen, MF, 2019) |
| "The aim of this study was to evaluate serum kidney injury molecule-1 (KIM-1) as a new diagnostic marker of renal dysfunction in chronic hepatitis B (CHB) patients receiving long-term adefovir dipivoxil (ADV) treatment." | 7.83 | Circulating kidney injury molecule-1 is a novel diagnostic biomarker for renal dysfunction during long-term adefovir therapy in chronic hepatitis B. ( Li, Z; Liu, Z; Shen, C; Wang, W; Wang, Y; Zhao, C; Zhao, Q, 2016) |
| " The aim of the study was to assess the mechanisms involved by determining whether magnesium alone or combined with calcitriol treatments differentially impacts vascular calcification (VC) in male Sprague-Dawley rats with adenine-induced CKD." | 7.81 | Magnesium Modifies the Impact of Calcitriol Treatment on Vascular Calcification in Experimental Chronic Kidney Disease. ( Adams, MA; Barron, H; Holden, RM; Laverty, K; McCabe, KM; Svajger, B; Zelt, JG, 2015) |
| " The negative impact of inflammation in this CKD model was overcome by the marked anti-inflammatory effects of thalidomide, promoting renal protection." | 7.79 | Thalidomide suppresses inflammation in adenine-induced CKD with uraemia in mice. ( Blanco, P; Catanozi, S; de Sá Lima, L; Degaspari, S; Dellê, H; Noronha, IL; Santana, AC; Scavone, C; Silva, C; Solez, K, 2013) |
| " Relationships between tenofovir use and proteinuria and chronic kidney disease (CKD) outcomes were examined using multivariable logistic regression models." | 7.79 | Tenofovir treatment duration predicts proteinuria in a multiethnic United States Cohort of children and adolescents with perinatal HIV-1 infection. ( Chernoff, MC; Hazra, R; Kopp, JB; Mofenson, LM; Patel, K; Purswani, M; Scott, GB; Seage, GR; Siberry, GK; Van Dyke, RB, 2013) |
| "Proteinuria was observed in 27% of 153 patients taking tenofovir for more than 1 year." | 7.79 | Tenofovir-associated proteinuria. ( Bartlett, H; Gibson, A; Kelly, MD; Patten, J; Rowling, D, 2013) |
| "Some studies have suggested that exposure to antiretroviral therapy (ART) with abacavir is associated with an increased risk of acute myocardial infarction (AMI)." | 7.77 | Abacavir use and risk of acute myocardial infarction and cerebrovascular events in the highly active antiretroviral therapy era. ( Bedimo, RJ; Drechsler, H; Tebas, P; Vidiella, G; Westfall, AO, 2011) |
| " Here, CKD was developed by an oral dosage of adenine (AD) in the mice model." | 5.62 | Morin hydrate attenuates adenine-induced renal fibrosis via targeting cathepsin D signaling. ( Kang, SC; Sharma, C; Singh, MP, 2021) |
| "Renal fibrosis is a complication of kidney injury and associated with increased risk of morbidity and mortality." | 5.48 | Ameliorative effect of ursolic acid on renal fibrosis in adenine-induced chronic kidney disease in rats. ( Begum, J; Kumar, D; Kumar, P; Lingaraju, MC; Mathesh, K; Sharma, A; Singh, TU; Thakur, R, 2018) |
| "WT adenine-fed mice were anemic and had low serum iron, elevated Hamp, and elevated IL6 and TNF-α." | 5.43 | Lack of hepcidin ameliorates anemia and improves growth in an adenine-induced mouse model of chronic kidney disease. ( Akchurin, O; Boskey, A; Choi, ME; Cunningham-Rundles, S; Doty, SB; Patino, E; Rivella, S; Sureshbabu, A; Zhu, YS, 2016) |
| "Medial vascular calcification is highly prevalent in chronic kidney disease (CKD), and it is a risk factor for mortality." | 5.39 | Cardiovascular disease in an adenine-induced model of chronic kidney disease: the temporal link between vascular calcification and haemodynamic consequences. ( Adams, MA; Holden, RM; Pang, J; Shobeiri, N, 2013) |
| "The treatment of chronic hepatitis B (CHB) in patients with chronic kidney disease (CKD) is based on nucleoside (lamivudine, telbivudine, entecavir) or nucleotide (adefovir, tenofovir) analogues (NAs), but it may be complex and the information is scarce." | 4.90 | Review article: nucleos(t)ide analogues in patients with chronic hepatitis B virus infection and chronic kidney disease. ( Cholongitas, E; Papatheodoridis, G; Pipili, C, 2014) |
| "Colchicine inhibited tubulin polymerization and caspase-1 activation and attenuated kidney inflammation and fibrosis in a mouse model of adenine-induced KI." | 4.31 | Beneficiary Effects of Colchicine on Inflammation and Fibrosis in a Mouse Model of Kidney Injury. ( Arazi, E; Landau, D; Segev, Y; Shukri, N; Tobar, A, 2023) |
| " In this study, the hypothesis that RBM supplementation is able to protect against kidney dysfunction and hypertension was tested by using an adenine-induced CKD model." | 4.31 | Dietary Resveratrol Butyrate Monoester Supplement Improves Hypertension and Kidney Dysfunction in a Young Rat Chronic Kidney Disease Model. ( Chang, CI; Chang-Chien, GP; Hou, CY; Hsu, CN; Lin, S; Tain, YL, 2023) |
| "Tenofovir alafenamide (TAF) may be preferable to other nucleos(t)ide analogues (NA) regarding outcomes against chronic hepatitis B virus (HBV) infection." | 4.12 | Switching to tenofovir alafenamide for nucleos(t)ide analogue-experienced patients with chronic hepatitis B: week 144 results from a real-world, multi-centre cohort study. ( Amagase, H; Azuma, K; Dohmen, K; Furusyo, N; Hayashi, J; Ichiki, Y; Kajiwara, E; Kato, M; Kawano, A; Koyanagi, T; Kuniyoshi, M; Morita, C; Nakamuta, M; Nomura, H; Ogawa, E; Ooho, A; Satoh, T; Shimoda, S; Sugimoto, R; Takahashi, K; Yamashita, N, 2022) |
| "Although tenofovir alafenamide (TAF) and besifovir dipivoxil maleate (BSV) are potent antiviral agents in the treatment of chronic hepatitis B (CHB) infection, their renal safety profiles have not been previously compared." | 4.12 | Similar risk of kidney function decline between tenofovir alafenamide and besifovir dipivoxil maleate in chronic hepatitis B. ( Ahn, SH; Jung, CY; Kim, BS; Kim, HW; Kim, SU; Lee, HW; Lee, JI, 2022) |
| "SKI protected against adenine-induced kidney injury and fibrosis and exerted anti-inflammatory, and antioxidant effects in CRF rats." | 4.12 | Protective effect and mechanism of Shenkang injection on adenine-induced chronic renal failure in rats. ( Chen, R; Sun, G; Sun, X; Xu, L; Zeng, W; Zhang, X, 2022) |
| " We also investigated its efficacy in unilateral ureteral obstruction (UUO)-treated mice and in adenine-induced CKD rats." | 4.12 | Mucin-fused myeloid-derived growth factor (MYDGF164) exhibits a prolonged serum half-life and alleviates fibrosis in chronic kidney disease. ( Du, P; Wang, H; Wang, T; Yang, M; Yin, H, 2022) |
| "We investigated antifibrotic effects of capsaicin in two mouse renal fibrosis models as follows: C57BL/6J mice were subjected to unilateral ureteral obstruction (UUO) and fed with an adenine-rich diet." | 4.12 | Capsaicin ameliorates renal fibrosis by inhibiting TGF-β1-Smad2/3 signaling. ( Li, X; Liu, Z; Meng, D; Tang, S; Wang, H; Wang, W; Wu, Y; Xia, W; Zhang, J; Zhou, X, 2022) |
| " The efficacy of the CTGF vaccine on renal fibrosis was evaluated in adenine-induced CKD and unilateral ureteral obstruction (UUO) murine models." | 4.12 | Vaccination against connective tissue growth factor attenuates the development of renal fibrosis. ( Azegami, T; Hayashi, K; Hishikawa, A; Itoh, H; Nakamichi, R; Nakayama, T; Sugita, E; Yoshimoto, N, 2022) |
| " The characterizations were analyzed by physicochemical methods, and the renoprotections were processed in adenine-induced chronic kidney diseases (CKD) models of mice." | 4.02 | Renoprotective effects of enzyme-hydrolyzed polysaccharides from Auricularia polytricha on adenine-induced chronic kidney diseases in mice. ( Cui, W; Jia, L; Li, J; Pang, H; Song, X; Zhang, J, 2021) |
| "2% adenine diet for 14 weeks developed CKD with elevated plasma levels of TMAO, provision of a non-lethal inhibitor of gut microbial trimethylamine (TMA) production, iodomethylcholine (IMC), significantly reduced multiple markers of renal injury (plasma creatinine, cystatin C, FGF23, and TMAO), reduced histopathologic evidence of fibrosis, and markedly attenuated development of microalbuminuria." | 4.02 | Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice. ( Charugundla, S; Guo, F; Hazen, SL; Jia, X; Kaczor-Urbanowicz, KE; Lusis, AJ; Magyar, C; Miikeda, A; Nicholas, SB; Pellegrini, M; Shih, DM; Wang, Z; Zhang, W; Zhou, Z; Zuckerman, J, 2021) |
| "Uremia was induced by feeding Wistar rats an adenine-enriched diet (0." | 3.96 | Digital radiography as an alternative method in the evaluation of bone density in uremic rats. ( Carmo, WB; Castro, BBA; Custodio, MR; Jorgetti, V; Oliveira, RSMF; Peters, VM; Sanders-Pinheiro, H, 2020) |
| " Upon folic acid injection, a model of acute kidney injury, XLKO and WT mice exhibited similar degrees of tubulopathy; however, plasma phosphate and FGF23 elevations were modestly blunted in XLKO males, but not in females, compared to WT counterparts." | 3.96 | Extra-Large Gα Protein (XLαs) Deficiency Causes Severe Adenine-Induced Renal Injury with Massive FGF23 Elevation. ( Bastepe, M; Cui, Q; He, Q; Matthias, J; Plagge, A; Shumate, LT, 2020) |
| "Renal toxicity of adefovir disoproxil (ADV) and tenofovir disoproxil fumarate (TDF) is a significant concern in chronic hepatitis B (CHB) patients." | 3.91 | In Vitro and In Vivo Renoprotective Effects of Telbivudine in Chronic Hepatitis B Patients Receiving Nucleotide Analogue. ( Chan, TM; Fung, J; Lai, CL; Liu, SH; Mak, LY; Seto, WK; Wong, DK; Yap, DY; Yuen, MF, 2019) |
| " Here we investigated long-term effects of PHDI treatment in adenine-induced nephropathy as a model for chronic tubulointerstitial nephritis." | 3.91 | Mononuclear phagocytes orchestrate prolyl hydroxylase inhibition-mediated renoprotection in chronic tubulointerstitial nephritis. ( Beneke, A; Burzlaff, N; Daniel, C; Eckardt, KU; Goppelt-Struebe, M; Herrmann, M; Jantsch, J; Kalucka, J; Katschinski, DM; Klanke, B; Mayer, M; Palsson, R; Schatz, V; Schley, G; Thorsteinsdottir, M; Weidemann, A; Willam, C, 2019) |
| "Adenine phosphoribosyltransferase (APRT) deficiency is a hereditary purine metabolism disorder that causes kidney stones and chronic kidney disease (CKD)." | 3.91 | Long-term renal outcomes of APRT deficiency presenting in childhood. ( Agustsdottir, IM; Edvardsson, VO; Indridason, OS; Palsson, R; Runolfsdottir, HL, 2019) |
| "Adenine mice exhibited significantly higher mean serum urea, creatinine, and renal expression of the pro-inflammatory markers Interleukin-6 (IL-6), C-X-C motif chemokine 10 (CXCL10), and Interleukin-1β (IL-1β), in addition to prominent renal fibrosis and reduced renal Klotho gene expression compared to the control." | 3.88 | Fish Oil Supplementation Reduces Inflammation but Does Not Restore Renal Function and Klotho Expression in an Adenine-Induced CKD Model. ( Baia, LC; de Borst, MH; Heilberg, IP; Henao Agudelo, JS; Machado, JR; Navis, GJ; Ormanji, MS; Santos, ARP; Saraiva Câmara, NO, 2018) |
| " Adenine treatment reduced body weight, creatinine renal clearance, and increased water intake and urine output, as well as the plasma concentrations of urea and creatinine, neutrophil gelatinase-associated lipocalin, and N-acetyl-β-D-glucosaminidase activity, and albumin in urine." | 3.88 | The effect of sildenafil on rats with adenine-Induced chronic kidney disease. ( Adham, SA; Al Kalbani, J; Al Suleimani, Y; Al Za'abi, M; Ali, BH; Karaca, T; Manoj, P; Nemmar, A; Yasin, J, 2018) |
| "The aim of this study was to evaluate serum kidney injury molecule-1 (KIM-1) as a new diagnostic marker of renal dysfunction in chronic hepatitis B (CHB) patients receiving long-term adefovir dipivoxil (ADV) treatment." | 3.83 | Circulating kidney injury molecule-1 is a novel diagnostic biomarker for renal dysfunction during long-term adefovir therapy in chronic hepatitis B. ( Li, Z; Liu, Z; Shen, C; Wang, W; Wang, Y; Zhao, C; Zhao, Q, 2016) |
| "To study the therapeutic effect of chrysin, a flavonoid with strong antioxidant and anti-inflammatory activities, on adenine-induced chronic kidney diseases (CKD) in rats." | 3.83 | Therapeutic Effect of Chrysin on Adenine-Induced Chronic Kidney Disease in Rats. ( Adham, SA; Al Za'abi, M; Ali, BH; Nemmar, A; Schupp, N; Yasin, J, 2016) |
| " The aim of the study was to assess the mechanisms involved by determining whether magnesium alone or combined with calcitriol treatments differentially impacts vascular calcification (VC) in male Sprague-Dawley rats with adenine-induced CKD." | 3.81 | Magnesium Modifies the Impact of Calcitriol Treatment on Vascular Calcification in Experimental Chronic Kidney Disease. ( Adams, MA; Barron, H; Holden, RM; Laverty, K; McCabe, KM; Svajger, B; Zelt, JG, 2015) |
| " MR images were acquired on two mouse models of kidney injury: adenine-induced chronic kidney disease (CKD) and rhabdomyolysis-induced acute kidney injury (AKI)." | 3.80 | Assessment with unenhanced MRI techniques of renal morphology and hemodynamic changes during acute kidney injury and chronic kidney disease in mice. ( Abramovitch, R; Axelrod, JH; Heyman, SN; Milman, Z; Nachmansson, N, 2014) |
| " The negative impact of inflammation in this CKD model was overcome by the marked anti-inflammatory effects of thalidomide, promoting renal protection." | 3.79 | Thalidomide suppresses inflammation in adenine-induced CKD with uraemia in mice. ( Blanco, P; Catanozi, S; de Sá Lima, L; Degaspari, S; Dellê, H; Noronha, IL; Santana, AC; Scavone, C; Silva, C; Solez, K, 2013) |
| " Relationships between tenofovir use and proteinuria and chronic kidney disease (CKD) outcomes were examined using multivariable logistic regression models." | 3.79 | Tenofovir treatment duration predicts proteinuria in a multiethnic United States Cohort of children and adolescents with perinatal HIV-1 infection. ( Chernoff, MC; Hazra, R; Kopp, JB; Mofenson, LM; Patel, K; Purswani, M; Scott, GB; Seage, GR; Siberry, GK; Van Dyke, RB, 2013) |
| "Proteinuria was observed in 27% of 153 patients taking tenofovir for more than 1 year." | 3.79 | Tenofovir-associated proteinuria. ( Bartlett, H; Gibson, A; Kelly, MD; Patten, J; Rowling, D, 2013) |
| "Some studies have suggested that exposure to antiretroviral therapy (ART) with abacavir is associated with an increased risk of acute myocardial infarction (AMI)." | 3.77 | Abacavir use and risk of acute myocardial infarction and cerebrovascular events in the highly active antiretroviral therapy era. ( Bedimo, RJ; Drechsler, H; Tebas, P; Vidiella, G; Westfall, AO, 2011) |
| " Although no dosage adjustment is needed for Oral Nirmatrelvir/Ritonavir in patients with mild renal impairment and coronavirus disease 2019, the dosage is reduced to twice daily in those with moderate renal impairment." | 3.01 | Medication safety in chronic kidney disease. ( Singh, S, 2023) |
| "Proteinuria is also now recognized as a common finding in individuals living with HIV." | 2.55 | Renal effects of novel antiretroviral drugs. ( Jones, R; Levy, JB; Milburn, J, 2017) |
| "Icariin at the dosage of 100 mg/kg/d and 200 mg/kg/d markedly ameliorated rat renal function in a dose-dependent manner." | 1.91 | Icariin, the main prenylflavonoid of Epimedii Folium, ameliorated chronic kidney disease by modulating energy metabolism via AMPK activation. ( Lu, J; Lv, C; Yang, W; Zhang, X; Zhao, Y, 2023) |
| " However, considering its rapid uptake into target cells, we suggest only a cautious increase of tenofovir alafenamide dosage intervals to 2 or 3 days only in case of moderate or severe CKD, respectively." | 1.91 | Population pharmacokinetic modelling to characterize the effect of chronic kidney disease on tenofovir exposure after tenofovir alafenamide administration. ( Alves Saldanha, S; Andre, P; Buclin, T; Cavassini, M; Courlet, P; Decosterd, LA; Desfontaine, V; Guidi, M; Kusejko, K; Thoueille, P, 2023) |
| "Adenine was found to elevate the levels of serum creatinine, urea, uric acid, sodium, potassium, chloride, magnesium, and phosphorus and reduce the level of serum calcium." | 1.91 | Roflumilast alleviates adenine-induced chronic kidney disease by regulating inflammatory biomarkers. ( Chudasama, P; Patel, P; Patel, S; Raval, M; Soni, S, 2023) |
| "An adenine diet was administered to male Wistar rats to induce AMC." | 1.91 | Towards a better understanding of arterial calcification disease progression in CKD: investigation of early pathological alterations. ( D'Haese, P; De Meyer, G; Guns, PJ; Neutel, C; Opdebeeck, B; Van den Bergh, G; Verhulst, A, 2023) |
| "Renal fibrosis is the final manifestation of chronic kidney disease (CKD) regardless of etiology." | 1.91 | Effects of long-term tubular HIF-2α overexpression on progressive renal fibrosis in a chronic kidney disease model. ( Kim, DA; Kim, M; Kong, KH; Lee, MR; Oh, HJ, 2023) |
| " The collective results support the utility of AOPPs as a potential target for drug and/or dosage adjustment in CKD patients." | 1.72 | Advanced oxidation protein products upregulate ABCB1 expression and activity via HDAC2-Foxo3α-mediated signaling in vitro and in vivo. ( Chen, Y; Feng, H; Lin, Z; Mo, L; Wang, X; Xun, T; Yang, X; Ye, C; Zhang, M; Zhao, J, 2022) |
| "Vascular calcification is commonly observed in chronic kidney disease (CKD) and is associated with increased morbidity and mortality." | 1.72 | Exogenous BMP7 administration attenuated vascular calcification and improved bone disorders in chronic uremic rats. ( Kuo, WH; Lee, CT; Lee, WC; Tain, YL; Wang, Y, 2022) |
| "Renal fibrosis is an inevitable outcome of various manifestations of progressive chronic kidney diseases (CKD)." | 1.72 | The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice. ( Alolga, RN; Bian, XY; Chen, C; Jiang, H; Li, J; Liu, HL; Liu, SJ; Liu, YF; Shan, JJ; Si, ZL; Tan, NH; Wang, H; Wu, WH; Zhang, ZH; Zhou, W, 2022) |
| "Renal fibrosis is the final stage of chronic kidney injury characterized by glomerulosclerosis and tubulointerstitial fibrosis with parenchymal destruction." | 1.72 | Nanoparticles Formulation Improves the Antifibrogenic Effect of Quercetin on an Adenine-Induced Model of Chronic Kidney Disease. ( Bastidas-Ramírez, BE; Gasca-Lozano, LE; Gurrola-Díaz, CM; Hernández-Ortega, LD; Martínez-Limón, FJ; Mena-Enríquez, M; Salazar-Montes, AM; Sánchez-Jaramillo, EA; Vargas-Guerrero, B; Vera-Cruz, JM, 2022) |
| "Metformin, a first-line drug for type 2 diabetes, exerts beneficial pleiotropic actions beyond its prescribed use and incipient data have revealed protective effects against the development of kidney impairment." | 1.72 | Progression of established non-diabetic chronic kidney disease is halted by metformin treatment in rats. ( Corremans, R; D'Haese, PC; De Broe, ME; Leysen, H; Maudsley, S; Neven, E; Verhulst, A; Vervaet, BA, 2022) |
| "Adenine was used to establish a rat model of CKD, biochemical testing, histopathologic examination, ELISA, immunohistochemical assay, western blot assay, and fecal microbiota 16s rRNA analysis was used to test the effect of PNS on CKD rats." | 1.72 | Panax notoginseng saponins alleviate damage to the intestinal barrier and regulate levels of intestinal microbes in a rat model of chronic kidney disease. ( Fan, J; Ma, X; Mao, N; Ren, S; Xie, J; Zheng, Y, 2022) |
| " Here, CKD was developed by an oral dosage of adenine (AD) in the mice model." | 1.62 | Morin hydrate attenuates adenine-induced renal fibrosis via targeting cathepsin D signaling. ( Kang, SC; Sharma, C; Singh, MP, 2021) |
| "Cardiorenal syndrome is a major cause of mortality in patients with chronic kidney disease (CKD)." | 1.56 | The guanylate cyclase C agonist linaclotide ameliorates the gut-cardio-renal axis in an adenine-induced mouse model of chronic kidney disease. ( Abe, T; Akiyama, Y; Asaji, K; Fukuda, S; Ho, HJ; Ito, S; Iwasaki, T; Kanemitsu, Y; Kikuchi, K; Kure, S; Matsuhashi, T; Mishima, E; Nanto-Hara, F; Oikawa, Y; Owada, Y; Saigusa, D; Soga, T; Suzuki, C; Suzuki, T; Tomioka, Y; Tsukimi, T, 2020) |
| "Renal fibrosis is one of the main causes of chronic kidney disease." | 1.56 | Knockdown of CK2α reduces ( Go, G; Lee, SH; Lim, JH; Yoon, YM; Yun, CW, 2020) |
| "Vascular calcification is a common finding in atherosclerosis and in patients with chronic kidney disease." | 1.51 | AT2 receptor stimulation inhibits phosphate-induced vascular calcification. ( Bai, HY; Higaki, A; Higaki, J; Horiuchi, M; Iwanami, J; Kan-No, H; Kukida, M; Min, LJ; Mogi, M; Okura, T; Shan, BS; Tsukuda, K; Yamauchi, T, 2019) |
| "Kidney fibrosis is one of the main pathological findings of progressive chronic kidney disease (CKD) although the pathogenesis of renal scar formation remains incompletely explained." | 1.51 | Chronic kidney disease induced by an adenine rich diet upregulates integrin linked kinase (ILK) and its depletion prevents the disease progression. ( Calleros, L; de Frutos, S; García-Jérez, A; Griera, M; Hatem-Vaquero, M; Luengo, A; O'Valle, F; Rodríguez-Puyol, D; Rodríguez-Puyol, M, 2019) |
| "Kidney fibrosis was associated with upregulation of 6-keto-PGI2/TXB2 in the rat kidney tissue." | 1.51 | Comparison of the Effects of Indobufen and Warfarin in a Rat Model of Adenine-Induced Chronic Kidney Disease. ( Gong, J; He, Q; Jin, J; Li, Y; Lou, X; Zhao, L, 2019) |
| "Bupropion was used as a probe substrate for hepatic CYP2B function using rat liver microsomes." | 1.51 | The effect of chronic kidney disease on CYP2B expression and activity in male Wistar rats. ( Kucey, AS; RaoPeters, AAE; Tieu, A; Tonial, NC; Urquhart, BL; Velenosi, TJ, 2019) |
| "Renal fibrosis is a complication of kidney injury and associated with increased risk of morbidity and mortality." | 1.48 | Ameliorative effect of ursolic acid on renal fibrosis in adenine-induced chronic kidney disease in rats. ( Begum, J; Kumar, D; Kumar, P; Lingaraju, MC; Mathesh, K; Sharma, A; Singh, TU; Thakur, R, 2018) |
| "Renal fibrosis is a common pathogenic response to injury in chronic kidney disease (CKD)." | 1.48 | RIPK3 promotes kidney fibrosis via AKT-dependent ATP citrate lyase. ( Choi, AM; Choi, ME; Chung, KP; Imamura, M; Moon, JS; Muthukumar, T; Nakahira, K; Ryter, SW; Shingarev, R, 2018) |
| "Curcumin was found to significantly abate adenine-induced toxic effects such as reduced creatinine clearance, elevated neutrophil gelatinase-associated lipocalin levels and raised urinary N-acetyl-β-D-glucosaminidase activities." | 1.48 | Curcumin Ameliorates Kidney Function and Oxidative Stress in Experimental Chronic Kidney Disease. ( Al Abri, N; Al Bahlani, S; Al Dhahli, B; Al Kalbani, J; Al Suleimani, Y; Al Za'abi, M; Al-Salam, S; Ali, BH; Ashique, M; Hartmann, C; Manoj, P; Naser, HT; Nemmar, A; Schupp, N; Yasin, J, 2018) |
| "Quercetin-treated model rats had reduced serum levels of parathyroid hormone (PTH), inorganic phosphate, increased urine protein-to-creatinine ratio, increased urine antioxidants, serum lactate dehydrogenase (LDH), and interleukin (IL)-8 when compared with the untreated model group and the control group." | 1.48 | Quercetin Treatment Improves Renal Function and Protects the Kidney in a Rat Model of Adenine-Induced Chronic Kidney Disease. ( Li, R; Liang, YN; Song, Y; Yang, H, 2018) |
| " To study a possible direct effect of metformin on the development of vascular calcification, independent of its effect on renal function, metformin (200 mg/kg/day) or vehicle was dosed for ten weeks to rats with warfarin-induced vascular calcification." | 1.48 | Metformin prevents the development of severe chronic kidney disease and its associated mineral and bone disorder. ( Brand, K; D'Haese, PC; De Broe, ME; De Maré, A; Gottwald-Hostalek, U; Kamel, S; Lalau, JD; Neven, E; Opdebeeck, B; Verhulst, A; Vervaet, B, 2018) |
| "Rhein is an anthraquinone compound isolated from the medicinal plant rhubarb and mainly used in the clinical treatment of diabetic nephropathy." | 1.46 | Rhein reverses Klotho repression via promoter demethylation and protects against kidney and bone injuries in mice with chronic kidney disease. ( Cao, W; Duan, A; Lin, W; Liu, L; Liu, Z; Yin, S; Zhang, Q, 2017) |
| "WT adenine-fed mice were anemic and had low serum iron, elevated Hamp, and elevated IL6 and TNF-α." | 1.43 | Lack of hepcidin ameliorates anemia and improves growth in an adenine-induced mouse model of chronic kidney disease. ( Akchurin, O; Boskey, A; Choi, ME; Cunningham-Rundles, S; Doty, SB; Patino, E; Rivella, S; Sureshbabu, A; Zhu, YS, 2016) |
| " There were no discontinuations due to adverse events." | 1.43 | Pharmacokinetics and Safety of Tenofovir Alafenamide in HIV-Uninfected Subjects with Severe Renal Impairment. ( Custodio, JM; Fordyce, M; Garner, W; Kearney, BP; Ling, KH; Ramanathan, S; Vimal, M, 2016) |
| "Chrysin did not cause any overt adverse effect on the treated rats." | 1.42 | Ameliorative effect of chrysin on adenine-induced chronic kidney disease in rats. ( Adham, SA; Al Za'abi, M; Ali, BH; Nemmar, A; Schupp, N; Waly, MI; Yasin, J, 2015) |
| "Malnutrition and inflammation are also closely linked to an increased risk of cardiovascular death in CKD." | 1.40 | Phosphate overload directly induces systemic inflammation and malnutrition as well as vascular calcification in uremia. ( Kitazono, T; Masutani, K; Nakano, T; Noguchi, H; Ooboshi, H; Taniguchi, M; Tatsumoto, N; Tokumoto, M; Tsuruya, K; Yamada, S, 2014) |
| "Adenine-treated Sprague-Dawley rats were randomly assigned to receive continuous peritoneal injections of PDF with or without MGO for three weeks or were left untreated for the same duration." | 1.40 | Peritoneal fibrosis induced by intraperitoneal methylglyoxal injection: the role of concurrent renal dysfunction. ( Akimoto, T; Hirahara, I; Inoue, M; Kusano, E; Morishita, Y; Nagata, D; Onishi, A, 2014) |
| "Rosiglitazone (ROG) has been shown to exert beneficial effects on glycemic control and renal protection." | 1.39 | Rosiglitazone alleviates injury in rats with adenine‑induced chronic kidney disease. ( Hu, M; Huang, Y; Lei, Y; Liu, R; Wang, X; Yu, X; Zheng, Z, 2013) |
| "Medial vascular calcification is highly prevalent in chronic kidney disease (CKD), and it is a risk factor for mortality." | 1.39 | Cardiovascular disease in an adenine-induced model of chronic kidney disease: the temporal link between vascular calcification and haemodynamic consequences. ( Adams, MA; Holden, RM; Pang, J; Shobeiri, N, 2013) |
| "Adenine-treated rats developed severe CRI, with markedly elevated serum levels of phosphorus, PTH and FGF23, and reduced levels of serum 1,25(OH)(2)D(3)." | 1.33 | Effect of manipulating serum phosphorus with phosphate binder on circulating PTH and FGF23 in renal failure rats. ( Abe, M; Kobayashi, N; Miyata, S; Nagano, N; Wada, M; Wakita, S; Yamashita, T, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (0.96) | 29.6817 |
| 2010's | 111 (53.37) | 24.3611 |
| 2020's | 95 (45.67) | 2.80 |
| Authors | Studies |
|---|---|
| Melekoglu, E | 1 |
| Cetinkaya, MA | 1 |
| Kepekci-Tekkeli, SE | 1 |
| Kul, O | 1 |
| Samur, G | 1 |
| Yang, Y | 4 |
| Ha, S | 1 |
| Jeong, S | 1 |
| Jang, CW | 1 |
| Kim, J | 1 |
| Im, DS | 1 |
| Chung, HY | 1 |
| Chung, KW | 1 |
| Al Za'abi, M | 16 |
| Ali, H | 4 |
| Ali, BH | 18 |
| Guo, Y | 2 |
| Liu, F | 1 |
| Chen, M | 1 |
| Tian, Q | 1 |
| Tian, X | 1 |
| Xiong, Q | 1 |
| Huang, C | 1 |
| Thome, T | 1 |
| Coleman, MD | 1 |
| Ryan, TE | 2 |
| Gao, M | 2 |
| Zhang, Z | 4 |
| Zhang, Y | 9 |
| Li, M | 1 |
| Che, X | 1 |
| Cui, X | 1 |
| Wang, M | 2 |
| Xiong, Y | 1 |
| Ogawa, E | 2 |
| Nakamuta, M | 2 |
| Koyanagi, T | 2 |
| Ooho, A | 2 |
| Furusyo, N | 2 |
| Kajiwara, E | 2 |
| Dohmen, K | 2 |
| Kawano, A | 2 |
| Satoh, T | 2 |
| Takahashi, K | 2 |
| Azuma, K | 2 |
| Yamashita, N | 4 |
| Sugimoto, R | 2 |
| Amagase, H | 2 |
| Kuniyoshi, M | 2 |
| Ichiki, Y | 2 |
| Morita, C | 2 |
| Kato, M | 2 |
| Shimoda, S | 2 |
| Nomura, H | 2 |
| Hayashi, J | 2 |
| Bhatia, D | 1 |
| Capili, A | 1 |
| Nakahira, K | 2 |
| Muthukumar, T | 2 |
| Torres, LK | 1 |
| Choi, AMK | 1 |
| Choi, ME | 3 |
| Corremans, R | 1 |
| Neven, E | 2 |
| Maudsley, S | 1 |
| Leysen, H | 1 |
| De Broe, ME | 2 |
| D'Haese, PC | 2 |
| Vervaet, BA | 1 |
| Verhulst, A | 4 |
| Zhou, W | 2 |
| Chen, MM | 1 |
| Liu, HL | 2 |
| Si, ZL | 2 |
| Wu, WH | 2 |
| Jiang, H | 3 |
| Wang, LX | 1 |
| Vaziri, ND | 2 |
| An, XF | 1 |
| Su, K | 1 |
| Chen, C | 5 |
| Tan, NH | 2 |
| Zhang, ZH | 5 |
| Liu, Z | 7 |
| Wang, W | 4 |
| Li, X | 5 |
| Tang, S | 1 |
| Meng, D | 1 |
| Xia, W | 1 |
| Wang, H | 6 |
| Wu, Y | 3 |
| Zhou, X | 3 |
| Zhang, J | 6 |
| Samynathan, R | 1 |
| Subramanian, U | 1 |
| Venkidasamy, B | 1 |
| Shariati, MA | 1 |
| Chung, IM | 1 |
| Thiruvengadam, M | 1 |
| Liu, B | 1 |
| Deng, J | 2 |
| Jie, X | 1 |
| Lu, F | 1 |
| Liu, X | 5 |
| Zhang, D | 1 |
| Kudose, S | 1 |
| Lunenfeld, E | 1 |
| Markowitz, GS | 1 |
| Du, P | 1 |
| Wang, T | 3 |
| Yang, M | 3 |
| Yin, H | 2 |
| Ma, Z | 1 |
| Yang, Z | 3 |
| Feng, X | 1 |
| He, C | 3 |
| Li, R | 2 |
| Zhao, Y | 6 |
| Ge, Y | 1 |
| Song, C | 1 |
| Zhong, S | 1 |
| Sánchez-Jaramillo, EA | 1 |
| Gasca-Lozano, LE | 1 |
| Vera-Cruz, JM | 1 |
| Hernández-Ortega, LD | 1 |
| Gurrola-Díaz, CM | 1 |
| Bastidas-Ramírez, BE | 1 |
| Vargas-Guerrero, B | 1 |
| Mena-Enríquez, M | 1 |
| Martínez-Limón, FJ | 1 |
| Salazar-Montes, AM | 1 |
| Mendieta-Condado, E | 1 |
| Villaseñor-Tapia, EC | 1 |
| Gálvez-Gastelum, FJ | 1 |
| Yáñez-Sánchez, I | 1 |
| Pizano-Martínez, O | 1 |
| Canales-Aguirre, A | 1 |
| Márquez-Aguirre, AL | 1 |
| Chen, R | 1 |
| Xu, L | 2 |
| Zhang, X | 9 |
| Sun, G | 1 |
| Zeng, W | 1 |
| Sun, X | 2 |
| Moecke, DMP | 1 |
| Martins, GHC | 1 |
| Garlet, TC | 1 |
| Bonorino, KC | 1 |
| Luciani, MG | 1 |
| Bion, M | 1 |
| Dos Santos, B | 1 |
| da Silva Gevaerd, M | 1 |
| Filho, JA | 1 |
| Dos Santos, ARS | 1 |
| Vieira, DSC | 1 |
| Dafre, AL | 1 |
| de Camargo Hizume Kunzler, D | 1 |
| Xun, T | 1 |
| Lin, Z | 3 |
| Zhang, M | 2 |
| Mo, L | 1 |
| Chen, Y | 2 |
| Wang, X | 6 |
| Zhao, J | 4 |
| Ye, C | 1 |
| Feng, H | 2 |
| Yang, X | 4 |
| Nakayama, T | 1 |
| Azegami, T | 1 |
| Hayashi, K | 1 |
| Hishikawa, A | 1 |
| Yoshimoto, N | 1 |
| Nakamichi, R | 1 |
| Sugita, E | 1 |
| Itoh, H | 1 |
| Lee, CT | 1 |
| Kuo, WH | 1 |
| Tain, YL | 3 |
| Wang, Y | 11 |
| Lee, WC | 1 |
| Hamdy, MM | 1 |
| Abdel-Rahman, MS | 1 |
| Badary, DM | 1 |
| Sabra, MS | 1 |
| Wang, YN | 2 |
| Liu, HJ | 1 |
| Guo, ZY | 1 |
| Zou, L | 1 |
| Zhang, YM | 1 |
| Zhao, YY | 4 |
| Jung, CY | 1 |
| Kim, HW | 1 |
| Lee, JI | 1 |
| Lee, HW | 1 |
| Ahn, SH | 1 |
| Kim, SU | 1 |
| Kim, BS | 1 |
| Khattri, RB | 1 |
| Kim, K | 1 |
| Anderson, EM | 1 |
| Fazzone, B | 1 |
| Harland, KC | 1 |
| Hu, Q | 2 |
| Palzkill, VR | 1 |
| Cort, TA | 1 |
| O'Malley, KA | 1 |
| Berceli, SA | 1 |
| Scali, ST | 1 |
| Kim, H | 2 |
| Nam, BY | 1 |
| Park, J | 1 |
| Song, S | 1 |
| Kim, WK | 1 |
| Lee, K | 1 |
| Nam, TW | 1 |
| Park, JT | 1 |
| Yoo, TH | 1 |
| Kang, SW | 1 |
| Ko, G | 1 |
| Han, SH | 1 |
| Wollenhaupt, J | 1 |
| Frisch, J | 1 |
| Harlacher, E | 1 |
| Wong, DWL | 2 |
| Jin, H | 1 |
| Schulte, C | 1 |
| Vondenhoff, S | 1 |
| Moellmann, J | 2 |
| Klinkhammer, BM | 4 |
| Zhang, L | 4 |
| Baleanu-Curaj, A | 1 |
| Liehn, EA | 1 |
| Speer, T | 1 |
| Kazakov, A | 1 |
| Werner, C | 1 |
| van der Vorst, EPC | 1 |
| Selejan, SR | 1 |
| Hohl, M | 1 |
| Böhm, M | 1 |
| Kramann, R | 2 |
| Biessen, EAL | 1 |
| Lehrke, M | 2 |
| Marx, N | 2 |
| Jankowski, J | 2 |
| Maack, C | 1 |
| Boor, P | 3 |
| Prates Roma, L | 1 |
| Noels, H | 2 |
| Damrath, JG | 1 |
| Metzger, CE | 3 |
| Allen, MR | 4 |
| Wallace, JM | 1 |
| Momb, BA | 1 |
| Patino, E | 2 |
| Akchurin, OM | 1 |
| Miller, MS | 1 |
| Liu, YF | 1 |
| Alolga, RN | 1 |
| Liu, SJ | 1 |
| Bian, XY | 1 |
| Shan, JJ | 1 |
| Li, J | 9 |
| Liu, C | 4 |
| Li, S | 4 |
| Ji, S | 1 |
| Zheng, F | 1 |
| Guan, Y | 1 |
| Yang, G | 3 |
| Chen, L | 3 |
| Abdelrahman, AM | 3 |
| Manoj, P | 10 |
| Al-Suleimani, Y | 1 |
| Van den Bergh, G | 1 |
| Opdebeeck, B | 2 |
| Neutel, C | 2 |
| Guns, PJ | 1 |
| De Meyer, G | 1 |
| D'Haese, P | 2 |
| Awadalla, A | 1 |
| Hamam, ET | 1 |
| El-Senduny, FF | 1 |
| Omar, NM | 1 |
| Mahdi, MR | 1 |
| Barakat, N | 1 |
| Ammar, OA | 1 |
| Hussein, AM | 2 |
| Shokeir, AA | 1 |
| Khirallah, SM | 1 |
| Xie, J | 1 |
| Ma, X | 2 |
| Zheng, Y | 2 |
| Mao, N | 1 |
| Ren, S | 1 |
| Fan, J | 1 |
| Lin, CY | 2 |
| Wang, CC | 1 |
| Loh, JZ | 1 |
| Chiang, TC | 1 |
| Weng, TI | 1 |
| Chan, DC | 1 |
| Hung, KY | 1 |
| Chiang, CK | 1 |
| Liu, SH | 2 |
| Serrano, E | 1 |
| Whitaker-Menezes, D | 1 |
| Roche, M | 1 |
| Martinez Cantarin, MP | 1 |
| Sato, H | 6 |
| Goto, M | 3 |
| Nishimura, G | 3 |
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| Tokushima, H | 3 |
| Horii, Y | 3 |
| Takahashi, N | 7 |
| Kim, DA | 3 |
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| Sun, W | 4 |
| Chang, CI | 1 |
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| Chang-Chien, GP | 2 |
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| Hsu, CN | 2 |
| David, K | 1 |
| Dubois, V | 1 |
| Sommers, V | 1 |
| Schollaert, D | 1 |
| Deboel, L | 1 |
| Moermans, K | 1 |
| Carmeliet, G | 1 |
| Vanderschueren, D | 1 |
| Claessens, F | 1 |
| Evenepoel, P | 1 |
| Decallonne, B | 1 |
| Inatomi, T | 1 |
| Honma, M | 1 |
| Thoueille, P | 1 |
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| Patel, P | 1 |
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| Li, C | 4 |
| Huang, H | 5 |
| Wang, R | 2 |
| Zhang, C | 6 |
| Huang, S | 1 |
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| Mo, P | 1 |
| Yu, H | 3 |
| Chen, J | 3 |
| Yang, W | 1 |
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| Mohamed, FF | 1 |
| Amadeu de Oliveira, F | 1 |
| Kinoshita, Y | 1 |
| Yalamanchili, RR | 1 |
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| Millán, JL | 1 |
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| Lin, Y | 1 |
| Wei, J | 1 |
| Huang, J | 3 |
| Wang, S | 1 |
| Luo, Q | 1 |
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| Landau, D | 2 |
| Shukri, N | 1 |
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| Tobar, A | 1 |
| Segev, Y | 2 |
| Huang, X | 3 |
| Gao, L | 1 |
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| Peng, Y | 1 |
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| Huang, L | 2 |
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| Liu, H | 4 |
| Guo, Z | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot 12 Month, Randomized, Controlled Trial of Curcumin in Kidney Transplant Recipients[NCT03935958] | 20 participants (Anticipated) | Interventional | 2019-11-01 | Recruiting | |||
| The Effect of Telbivudine on Renal Function in Chronic Hepatitis B Patients With Mild to Moderate Renal Impairment[NCT03778567] | Phase 4 | 31 participants (Actual) | Interventional | 2013-08-01 | Completed | ||
| Effect of Spironolactone on the Progression of Coronary Calcification in Peritoneal Dialysis Patients[NCT03314493] | Phase 3 | 33 participants (Actual) | Interventional | 2014-11-07 | Completed | ||
| Adolescent Master Protocol[NCT01418014] | 678 participants (Actual) | Observational | 2007-03-31 | Completed | |||
| Randomized Placebo Controlled Double-blind Trial in CKD Patients Not on Dialysis to Evaluate the Effect of Sevelamer Carbonate in the Control of FGF-23 Serum Levels and Its Consequences in the Evolution of PTH, Calcitriol and Mineral Metabolism Parameters[NCT01220843] | Phase 3 | 98 participants (Actual) | Interventional | 2010-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for adenine and Renal Insufficiency, Chronic
| Article | Year |
|---|---|
Medication safety in chronic kidney disease.
Topics: Adenine; COVID-19; Humans; Kidney; Renal Insufficiency; Renal Insufficiency, Chronic; Tenofovir | 2023 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Adenine-induced chronic kidney disease in rats.
Topics: Adenine; Animals; Bone Diseases; Cardiovascular Diseases; Disease Models, Animal; Disease Progressio | 2018 |
Review article: nucleos(t)ide analogues in patients with chronic hepatitis B virus infection and chronic kidney disease.
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organopho | 2014 |
Chronic Kidney Disease and Antiretroviral Therapy in HIV-Positive Individuals: Recent Developments.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Glomerular Filtration Rate; HIV Inf | 2016 |
Renal effects of novel antiretroviral drugs.
Topics: Adenine; Alanine; Anti-HIV Agents; Atazanavir Sulfate; Cobicistat; Creatinine; Disease Progression; | 2017 |
1 trial available for adenine and Renal Insufficiency, Chronic
202 other studies available for adenine and Renal Insufficiency, Chronic
| Article | Year |
|---|---|
Effects of prebiotic oligofructose-enriched inulin on gut-derived uremic toxins and disease progression in rats with adenine-induced chronic kidney disease.
Topics: Adenine; Animals; Blood Urea Nitrogen; Cresols; Disease Models, Animal; Dysbiosis; Humans; Indican; | 2021 |
Comparison of two different toxin-induced kidney fibrosis models in terms of inflammatory responses.
Topics: Adenine; Animals; Cytokines; Disease Models, Animal; Fibrosis; Folic Acid; Inflammation; Male; Mice; | 2021 |
Effect of flaxseed on systemic inflammation and oxidative stress in diabetic rats with or without chronic kidney disease.
Topics: Adenine; Animals; Anti-Inflammatory Agents; Biological Factors; Diabetes Mellitus, Experimental; Dis | 2021 |
Huangjinsan ameliorates adenine-induced chronic kidney disease by regulating metabolic profiling.
Topics: Adenine; Animals; Chromatography, High Pressure Liquid; Male; Metabolomics; Rats; Rats, Sprague-Dawl | 2021 |
Mitochondrial Bioenergetic and Proteomic Phenotyping Reveals Organ-Specific Consequences of Chronic Kidney Disease in Mice.
Topics: Adenine; Animals; Electron Transport; Energy Metabolism; Feeding Behavior; Hydrogen Peroxide; Kidney | 2021 |
Steamed Panax notoginseng attenuates renal anemia in an adenine-induced mouse model of chronic kidney disease.
Topics: Adenine; Anemia; Animals; Animals, Outbred Strains; Disease Models, Animal; Dose-Response Relationsh | 2022 |
Sequential HBV treatment with tenofovir alafenamide for patients with chronic hepatitis B: week 96 results from a real-world, multicenter cohort study.
Topics: Adenine; Alanine; Antiviral Agents; Cohort Studies; DNA, Viral; Female; Hepatitis B Surface Antigens | 2022 |
Conditional deletion of myeloid-specific mitofusin 2 but not mitofusin 1 promotes kidney fibrosis.
Topics: Adenine; Animals; Female; Fibrosis; GTP Phosphohydrolases; Humans; Kidney; Male; Mice; Mitochondrial | 2022 |
Progression of established non-diabetic chronic kidney disease is halted by metformin treatment in rats.
Topics: Adenine; Animals; Canagliflozin; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; | 2022 |
Dihydroartemisinin suppresses renal fibrosis in mice by inhibiting DNA-methyltransferase 1 and increasing Klotho.
Topics: Adenine; Animals; Artemisinins; Azacitidine; beta Catenin; Biotin; DNA; DNA Modification Methylases; | 2022 |
Capsaicin ameliorates renal fibrosis by inhibiting TGF-β1-Smad2/3 signaling.
Topics: Adenine; Animals; Cadherins; Capsaicin; Disease Models, Animal; Fibrosis; Kidney; Kidney Diseases; M | 2022 |
S-Allylcysteine (SAC) Exerts Renoprotective Effects via Regulation of TGF- β1/Smad3 Pathway Mediated Matrix Remodeling in Chronic Renal Failure.
Topics: Adenine; Aged; Animals; Cysteine; Fibrosis; Humans; Kidney Failure, Chronic; Rats; Rats, Wistar; Ren | 2022 |
Protective effects of the Bupi Yishen formula on renal fibrosis through PI3K/AKT signaling inhibition.
Topics: Adenine; Animals; Drugs, Chinese Herbal; Fibrosis; Humans; Molecular Docking Simulation; Phosphatidy | 2022 |
CKD in a Patient Treated with Adefovir for Chronic Hepatitis B Virus Infection.
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; Humans; Organophosphonates; Renal Insufficiency, Ch | 2021 |
Mucin-fused myeloid-derived growth factor (MYDGF164) exhibits a prolonged serum half-life and alleviates fibrosis in chronic kidney disease.
Topics: Adenine; Animals; Disease Models, Animal; Fibrosis; Half-Life; Humans; Intercellular Signaling Pepti | 2022 |
The Emerging Evidence for a Protective Role of Fucoidan from
Topics: Adenine; Aged; Animals; Cognitive Dysfunction; Female; Humans; Laminaria; Male; Memory Disorders; Mi | 2022 |
Nanoparticles Formulation Improves the Antifibrogenic Effect of Quercetin on an Adenine-Induced Model of Chronic Kidney Disease.
Topics: Adenine; Animals; Antioxidants; Fibrosis; Male; Mice; Mice, Inbred C57BL; Nanoparticles; Quercetin; | 2022 |
Effects of Etanercept on TNF-
Topics: Adenine; Animals; Atrophy; Etanercept; Fibrosis; Rats; Renal Insufficiency, Chronic; Tumor Necrosis | 2022 |
Protective effect and mechanism of Shenkang injection on adenine-induced chronic renal failure in rats.
Topics: Adenine; Animals; Drugs, Chinese Herbal; Fibrosis; Kidney; Kidney Failure, Chronic; Rats; Rats, Spra | 2022 |
Aerobic Exercise Attenuates Kidney Injury, Improves Physical Performance, and Increases Antioxidant Defenses in Lungs of Adenine-Induced Chronic Kidney Disease Mice.
Topics: Adenine; Animals; Antioxidants; Catalase; Creatinine; Glutathione Peroxidase; Kidney; Lung; Mice; Ni | 2022 |
Switching to tenofovir alafenamide for nucleos(t)ide analogue-experienced patients with chronic hepatitis B: week 144 results from a real-world, multi-centre cohort study.
Topics: Adenine; Adult; Alanine; Antiviral Agents; DNA, Viral; Hepatitis B, Chronic; Humans; Renal Insuffici | 2022 |
Advanced oxidation protein products upregulate ABCB1 expression and activity via HDAC2-Foxo3α-mediated signaling in vitro and in vivo.
Topics: Adenine; Advanced Oxidation Protein Products; Animals; ATP Binding Cassette Transporter, Subfamily B | 2022 |
Vaccination against connective tissue growth factor attenuates the development of renal fibrosis.
Topics: Adenine; Animals; Connective Tissue Growth Factor; Fibrosis; Kidney; Kidney Diseases; Mice; Renal In | 2022 |
Exogenous BMP7 administration attenuated vascular calcification and improved bone disorders in chronic uremic rats.
Topics: Adenine; Animals; Bone Morphogenetic Protein 7; Core Binding Factor Alpha 1 Subunit; Hyperphosphatem | 2022 |
Effects of furosemide and tadalafil in both conventional and nanoforms against adenine-induced chronic renal failure in rats.
Topics: Adenine; Animals; Caspase 3; Furosemide; Humans; Kidney Failure, Chronic; Rats; Renal Insufficiency, | 2022 |
Integrative phosphatidylcholine metabolism through phospholipase A
Topics: Adenine; Animals; Lipid Metabolism; Phosphatidylcholines; Phospholipases; Rats; Renal Insufficiency, | 2023 |
Similar risk of kidney function decline between tenofovir alafenamide and besifovir dipivoxil maleate in chronic hepatitis B.
Topics: Adenine; Alanine; Antiviral Agents; Guanine; Hepatitis B; Hepatitis B, Chronic; Humans; Kidney; Long | 2022 |
Metabolomic profiling reveals muscle metabolic changes following iliac arteriovenous fistula creation in mice.
Topics: Adenine; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Arteriovenous Fistula; Arterioven | 2022 |
Lactobacillus acidophilus KBL409 Reduces Kidney Fibrosis via Immune Modulatory Effects in Mice with Chronic Kidney Disease.
Topics: Adenine; Animals; Disease Models, Animal; Fibrosis; Kidney; Lactobacillus acidophilus; Mice; Mice, I | 2022 |
Pro-oxidative priming but maintained cardiac function in a broad spectrum of murine models of chronic kidney disease.
Topics: Adenine; Animals; Anti-Inflammatory Agents; Apolipoproteins E; Cardiomyopathies; Disease Models, Ani | 2022 |
A novel murine model of combined insulin-dependent diabetes and chronic kidney disease has greater skeletal detriments than either disease individually.
Topics: Adenine; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Disease Models, Animal; Female; Fracture | 2022 |
Iron Supplementation Improves Skeletal Muscle Contractile Properties in Mice with CKD.
Topics: Actins; Adenine; Animals; Dextrans; Dietary Supplements; Iron; Mice; Muscle, Skeletal; Myosin Heavy | 2022 |
The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice.
Topics: Adenine; Animals; Bacteroides fragilis; Biological Products; Disease Models, Animal; Fibrosis; Gastr | 2022 |
Proximal tubular Bmal1 protects against chronic kidney injury and renal fibrosis by maintaining of cellular metabolic homeostasis.
Topics: Adenine; Animals; Fibrosis; Glutathione; Homeostasis; Homocysteine; Kidney; Mice; Renal Insufficienc | 2023 |
The effect of diminazene, an angiotensin-converting enzyme 2 activator, on adenine-induced chronic kidney disease in rats.
Topics: Adenine; Angiotensin-Converting Enzyme 2; Animals; Antioxidants; Creatinine; Diminazene; Kidney; Lis | 2023 |
Towards a better understanding of arterial calcification disease progression in CKD: investigation of early pathological alterations.
Topics: Adenine; Animals; Arteriosclerosis; Calcinosis; Calcium; Disease Progression; Male; Rats; Rats, Wist | 2023 |
Zinc oxide nanoparticles and spironolactone-enhanced Nrf2/HO-1 pathway and inhibited Wnt/β-catenin pathway in adenine-induced nephrotoxicity in rats.
Topics: Adenine; Animals; Anti-Inflammatory Agents; Antioxidants; beta Catenin; Male; Nanoparticles; NF-E2-R | 2022 |
Panax notoginseng saponins alleviate damage to the intestinal barrier and regulate levels of intestinal microbes in a rat model of chronic kidney disease.
Topics: Adenine; Animals; Fibrosis; Intestines; Panax notoginseng; Rats; Renal Insufficiency, Chronic; RNA, | 2022 |
Therapeutic Ultrasound Halts Progression of Chronic Kidney Disease In Vivo via the Regulation of Markers Associated with Renal Epithelial-Mesenchymal Transition and Senescence.
Topics: Adenine; Animals; Biomarkers; Epithelial-Mesenchymal Transition; Fibrosis; Kidney; Mice; Renal Insuf | 2022 |
Uremic Myopathy and Mitochondrial Dysfunction in Kidney Disease.
Topics: Adenine; Animals; Fatty Acids; Glucose; Mice; Mitochondria; Muscle Fibers, Skeletal; Muscle, Skeleta | 2022 |
Upacicalcet, a positive allosteric modulator of the calcium-sensing receptor, prevents vascular calcification and bone disorder in a rat adenine-induced secondary hyperparathyroidism model.
Topics: Adenine; Animals; Bone Diseases; Calcium; Hyperparathyroidism, Secondary; Hyperplasia; Parathyroid H | 2023 |
Upacicalcet, a positive allosteric modulator of the calcium-sensing receptor, prevents vascular calcification and bone disorder in a rat adenine-induced secondary hyperparathyroidism model.
Topics: Adenine; Animals; Bone Diseases; Calcium; Hyperparathyroidism, Secondary; Hyperplasia; Parathyroid H | 2023 |
Upacicalcet, a positive allosteric modulator of the calcium-sensing receptor, prevents vascular calcification and bone disorder in a rat adenine-induced secondary hyperparathyroidism model.
Topics: Adenine; Animals; Bone Diseases; Calcium; Hyperparathyroidism, Secondary; Hyperplasia; Parathyroid H | 2023 |
Upacicalcet, a positive allosteric modulator of the calcium-sensing receptor, prevents vascular calcification and bone disorder in a rat adenine-induced secondary hyperparathyroidism model.
Topics: Adenine; Animals; Bone Diseases; Calcium; Hyperparathyroidism, Secondary; Hyperplasia; Parathyroid H | 2023 |
Upacicalcet, a positive allosteric modulator of the calcium-sensing receptor, prevents vascular calcification and bone disorder in a rat adenine-induced secondary hyperparathyroidism model.
Topics: Adenine; Animals; Bone Diseases; Calcium; Hyperparathyroidism, Secondary; Hyperplasia; Parathyroid H | 2023 |
Upacicalcet, a positive allosteric modulator of the calcium-sensing receptor, prevents vascular calcification and bone disorder in a rat adenine-induced secondary hyperparathyroidism model.
Topics: Adenine; Animals; Bone Diseases; Calcium; Hyperparathyroidism, Secondary; Hyperplasia; Parathyroid H | 2023 |
Upacicalcet, a positive allosteric modulator of the calcium-sensing receptor, prevents vascular calcification and bone disorder in a rat adenine-induced secondary hyperparathyroidism model.
Topics: Adenine; Animals; Bone Diseases; Calcium; Hyperparathyroidism, Secondary; Hyperplasia; Parathyroid H | 2023 |
Upacicalcet, a positive allosteric modulator of the calcium-sensing receptor, prevents vascular calcification and bone disorder in a rat adenine-induced secondary hyperparathyroidism model.
Topics: Adenine; Animals; Bone Diseases; Calcium; Hyperparathyroidism, Secondary; Hyperplasia; Parathyroid H | 2023 |
Upacicalcet, a positive allosteric modulator of the calcium-sensing receptor, prevents vascular calcification and bone disorder in a rat adenine-induced secondary hyperparathyroidism model.
Topics: Adenine; Animals; Bone Diseases; Calcium; Hyperparathyroidism, Secondary; Hyperplasia; Parathyroid H | 2023 |
Effects of long-term tubular HIF-2α overexpression on progressive renal fibrosis in a chronic kidney disease model.
Topics: Adenine; Animals; Basic Helix-Loop-Helix Transcription Factors; Cadherins; Fibronectins; Fibrosis; H | 2023 |
Effects of long-term tubular HIF-2α overexpression on progressive renal fibrosis in a chronic kidney disease model.
Topics: Adenine; Animals; Basic Helix-Loop-Helix Transcription Factors; Cadherins; Fibronectins; Fibrosis; H | 2023 |
Effects of long-term tubular HIF-2α overexpression on progressive renal fibrosis in a chronic kidney disease model.
Topics: Adenine; Animals; Basic Helix-Loop-Helix Transcription Factors; Cadherins; Fibronectins; Fibrosis; H | 2023 |
Effects of long-term tubular HIF-2α overexpression on progressive renal fibrosis in a chronic kidney disease model.
Topics: Adenine; Animals; Basic Helix-Loop-Helix Transcription Factors; Cadherins; Fibronectins; Fibrosis; H | 2023 |
Effects of long-term tubular HIF-2α overexpression on progressive renal fibrosis in a chronic kidney disease model.
Topics: Adenine; Animals; Basic Helix-Loop-Helix Transcription Factors; Cadherins; Fibronectins; Fibrosis; H | 2023 |
Effects of long-term tubular HIF-2α overexpression on progressive renal fibrosis in a chronic kidney disease model.
Topics: Adenine; Animals; Basic Helix-Loop-Helix Transcription Factors; Cadherins; Fibronectins; Fibrosis; H | 2023 |
Effects of long-term tubular HIF-2α overexpression on progressive renal fibrosis in a chronic kidney disease model.
Topics: Adenine; Animals; Basic Helix-Loop-Helix Transcription Factors; Cadherins; Fibronectins; Fibrosis; H | 2023 |
Effects of long-term tubular HIF-2α overexpression on progressive renal fibrosis in a chronic kidney disease model.
Topics: Adenine; Animals; Basic Helix-Loop-Helix Transcription Factors; Cadherins; Fibronectins; Fibrosis; H | 2023 |
Effects of long-term tubular HIF-2α overexpression on progressive renal fibrosis in a chronic kidney disease model.
Topics: Adenine; Animals; Basic Helix-Loop-Helix Transcription Factors; Cadherins; Fibronectins; Fibrosis; H | 2023 |
Yishen-Qingli-Huoxue formula attenuates renal fibrosis by inhibiting indoxyl sulfate via AhR/snai1 signaling.
Topics: Adenine; Animals; Indican; Molecular Docking Simulation; Rats; Renal Insufficiency, Chronic; Tandem | 2023 |
Yishen-Qingli-Huoxue formula attenuates renal fibrosis by inhibiting indoxyl sulfate via AhR/snai1 signaling.
Topics: Adenine; Animals; Indican; Molecular Docking Simulation; Rats; Renal Insufficiency, Chronic; Tandem | 2023 |
Yishen-Qingli-Huoxue formula attenuates renal fibrosis by inhibiting indoxyl sulfate via AhR/snai1 signaling.
Topics: Adenine; Animals; Indican; Molecular Docking Simulation; Rats; Renal Insufficiency, Chronic; Tandem | 2023 |
Yishen-Qingli-Huoxue formula attenuates renal fibrosis by inhibiting indoxyl sulfate via AhR/snai1 signaling.
Topics: Adenine; Animals; Indican; Molecular Docking Simulation; Rats; Renal Insufficiency, Chronic; Tandem | 2023 |
Yishen-Qingli-Huoxue formula attenuates renal fibrosis by inhibiting indoxyl sulfate via AhR/snai1 signaling.
Topics: Adenine; Animals; Indican; Molecular Docking Simulation; Rats; Renal Insufficiency, Chronic; Tandem | 2023 |
Yishen-Qingli-Huoxue formula attenuates renal fibrosis by inhibiting indoxyl sulfate via AhR/snai1 signaling.
Topics: Adenine; Animals; Indican; Molecular Docking Simulation; Rats; Renal Insufficiency, Chronic; Tandem | 2023 |
Yishen-Qingli-Huoxue formula attenuates renal fibrosis by inhibiting indoxyl sulfate via AhR/snai1 signaling.
Topics: Adenine; Animals; Indican; Molecular Docking Simulation; Rats; Renal Insufficiency, Chronic; Tandem | 2023 |
Yishen-Qingli-Huoxue formula attenuates renal fibrosis by inhibiting indoxyl sulfate via AhR/snai1 signaling.
Topics: Adenine; Animals; Indican; Molecular Docking Simulation; Rats; Renal Insufficiency, Chronic; Tandem | 2023 |
Yishen-Qingli-Huoxue formula attenuates renal fibrosis by inhibiting indoxyl sulfate via AhR/snai1 signaling.
Topics: Adenine; Animals; Indican; Molecular Docking Simulation; Rats; Renal Insufficiency, Chronic; Tandem | 2023 |
Dietary Resveratrol Butyrate Monoester Supplement Improves Hypertension and Kidney Dysfunction in a Young Rat Chronic Kidney Disease Model.
Topics: Adenine; Animals; Butyrates; Dietary Supplements; Hypertension; Kidney; Male; Oxidative Stress; Rats | 2023 |
Androgen therapy does not prevent bone loss and arterial calcifications in male rats with chronic kidney disease.
Topics: Adenine; Androgens; Animals; Bone Diseases, Metabolic; Dihydrotestosterone; Hypogonadism; Male; Rats | 2023 |
Ameliorating effect of probiotics in a rat model of chronic kidney disease.
Topics: Adenine; Animals; Fatty Acids, Volatile; Humans; Male; Phosphates; Probiotics; Rats; Renal Insuffici | 2023 |
Population pharmacokinetic modelling to characterize the effect of chronic kidney disease on tenofovir exposure after tenofovir alafenamide administration.
Topics: Adenine; Alanine; Anti-HIV Agents; HIV Infections; Humans; Renal Insufficiency, Chronic; Tenofovir | 2023 |
Roflumilast alleviates adenine-induced chronic kidney disease by regulating inflammatory biomarkers.
Topics: Adenine; Animals; Antioxidants; Biomarkers; Calcium; Creatinine; Kidney; Magnesium Chloride; Male; R | 2023 |
Jian-Pi-Yi-Shen formula restores iron metabolism from dysregulation in anemic rats with adenine-induced nephropathy.
Topics: Adenine; Anemia; Animals; Fibrosis; Hepcidins; Iron; Rats; Renal Insufficiency, Chronic | 2023 |
Icariin, the main prenylflavonoid of Epimedii Folium, ameliorated chronic kidney disease by modulating energy metabolism via AMPK activation.
Topics: Adenine; AMP-Activated Protein Kinases; Animals; Energy Metabolism; Fibrosis; Kidney; Male; Rats; Ra | 2023 |
Dentoalveolar Alterations in an Adenine-Induced Chronic Kidney Disease Mouse Model.
Topics: Adenine; Animals; Chronic Kidney Disease-Mineral and Bone Disorder; Hyperphosphatemia; Mice; Mice, I | 2023 |
Shen Qi Wan attenuates renal interstitial fibrosis through upregulating AQP1.
Topics: Adenine; Animals; Aquaporin 1; Cell Line; Drugs, Chinese Herbal; Epithelial-Mesenchymal Transition; | 2023 |
Beneficiary Effects of Colchicine on Inflammation and Fibrosis in a Mouse Model of Kidney Injury.
Topics: Adenine; Animals; Anti-Inflammatory Agents; Caspase 1; Colchicine; Disease Models, Animal; Fibrosis; | 2023 |
Huangqi-Danshen decoction reshapes renal glucose metabolism profiles that delays chronic kidney disease progression.
Topics: Adenine; Animals; Disease Models, Animal; Fibrosis; Glucose; Kidney; Mice; Pentose Phosphate Pathway | 2023 |
Vascular, valvular and kidney calcification manifested in mouse models of adenine-induced chronic kidney disease.
Topics: Adenine; Animals; Calcinosis; Calcium; Humans; Kidney; Male; Mice; Mice, Inbred C57BL; Minerals; Nep | 2023 |
Characterization of renal fibrosis in rats with chronic kidney disease by in vivo tomoelastography.
Topics: Adenine; Animals; Collagen; Elasticity Imaging Techniques; Fibrosis; Kidney; Rats; Renal Insufficien | 2023 |
Endothelial Dysfunction in Superior Mesenteric Arteries Isolated from Adenine-Induced Renal Failure in Model Rats.
Topics: Acetylcholine; Adenine; Animals; Biological Factors; Body Weight; Endothelium, Vascular; Enzyme Inhi | 2023 |
2,8-Dihydroxyadenine-induced nephropathy causes hexosylceramide accumulation with increased mTOR signaling, reduced levels of protective SirT3 expression and impaired renal mitochondrial function.
Topics: Adenine; Animals; Fibrosis; Inflammation; Kidney; Mice; Mice, Inbred C57BL; Mitochondria; Renal Insu | 2024 |
Diacerein mitigates adenine-induced chronic kidney disease in rats: Focus on TLR4/MYD88/TRAF6/NF-κB pathway.
Topics: Adaptor Proteins, Signal Transducing; Adenine; Animals; Anthraquinones; Humans; Male; Myeloid Differ | 2023 |
Obesity causes renal mitochondrial dysfunction and energy imbalance and accelerates chronic kidney disease in mice.
Topics: Adenine; Adenosine Triphosphate; Animals; Energy Metabolism; Kidney; Kidney Function Tests; Kidney T | 2019 |
The guanylate cyclase C agonist linaclotide ameliorates the gut-cardio-renal axis in an adenine-induced mouse model of chronic kidney disease.
Topics: Adenine; Animals; Cardio-Renal Syndrome; Disease Models, Animal; Disease Progression; Fibrosis; Gast | 2020 |
Digital radiography as an alternative method in the evaluation of bone density in uremic rats.
Topics: Adenine; Alkaline Phosphatase; Animals; Biomarkers; Bone Density; Bone Remodeling; Chronic Kidney Di | 2020 |
Renal oxygenation during the early stages of adenine-induced chronic kidney disease.
Topics: Adenine; Animals; Gene Expression Regulation; Hypoxia-Inducible Factor 1; Kidney; Male; Monitoring, | 2019 |
Effects of nicorandil on vascular and renal dysfunctions in adenine-induced nephropathy: Possible underlying mechanisms.
Topics: Adenine; Animals; Kidney; Male; Nicorandil; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic | 2019 |
Promising therapeutic effect of thapsigargin nanoparticles on chronic kidney disease through the activation of Nrf2 and FoxO1.
Topics: Adenine; Animals; Autophagy; Cell Line; Drug Evaluation, Preclinical; Endoplasmic Reticulum Stress; | 2019 |
Chronic treatment of curcumin improves hepatic lipid metabolism and alleviates the renal damage in adenine-induced chronic kidney disease in Sprague-Dawley rats.
Topics: Adenine; Animals; Body Weight; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; C | 2019 |
Extra-Large Gα Protein (XLαs) Deficiency Causes Severe Adenine-Induced Renal Injury with Massive FGF23 Elevation.
Topics: Acute Kidney Injury; Adenine; Animals; Blood Urea Nitrogen; Bone and Bones; Diet; Female; Fibroblast | 2020 |
Atorvastatin Improves Hepatic Lipid Metabolism and Protects Renal Damage in Adenine-Induced Chronic Kidney Disease in Sprague-Dawley Rats.
Topics: Adenine; Animals; Atorvastatin; Kidney; Lipid Metabolism; Liver; Male; Protective Agents; Rats; Rats | 2019 |
Osteocytes' expression of the PTH/PTHrP receptor has differing effects on endocortical and periosteal bone formation during adenine-induced CKD.
Topics: Adenine; Animals; Female; Mice; Osteocytes; Osteogenesis; Parathyroid Hormone; Parathyroid Hormone-R | 2020 |
Unfavorable Reduction in the Ratio of Endothelin B to A Receptors in Experimental 5/6 Nephrectomy and Adenine Models of Chronic Renal Insufficiency.
Topics: Adenine; Animals; Calcium; Disease Models, Animal; Gene Expression Regulation; Kidney Cortex; Male; | 2020 |
Cholesterol-Lowering Action of a Novel Nutraceutical Combination in Uremic Rats: Insights into the Molecular Mechanism in a Hepatoma Cell Line.
Topics: Acyl Coenzyme A; Adenine; Animals; Anticholesteremic Agents; Cell Line, Tumor; Cholesterol; Cysteine | 2020 |
Short-chain fatty acid mitigates adenine-induced chronic kidney disease via FFA2 and FFA3 pathways.
Topics: Adenine; Animals; Cytokines; Disease Models, Animal; Humans; Kidney Tubules, Collecting; Kidney Tubu | 2020 |
Gum arabic reduces inflammation, oxidative, and nitrosative stress in the gastrointestinal tract of mice with chronic kidney disease.
Topics: Adenine; Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Cecum; Disease Models, Animal; | 2020 |
Isolation, structural characterization of polysaccharide from Cephalosporium sinensis mycelia and its anti-nephritic effects in adenine-induced CKD rats.
Topics: Acremonium; Adenine; Animals; Galactose; Glucose; Male; Mannose; Mycelium; Polysaccharides; Rats; Ra | 2020 |
Female AhR Knockout Mice Develop a Minor Renal Insufficiency in an Adenine-Diet Model of Chronic Kidney Disease.
Topics: Adenine; Animals; Basic Helix-Loop-Helix Transcription Factors; Diet; Disease Models, Animal; Female | 2020 |
Reduction of Secreted Frizzled-Related Protein 5 Drives Vascular Calcification through Wnt3a-Mediated Rho/ROCK/JNK Signaling in Chronic Kidney Disease.
Topics: Adaptor Proteins, Signal Transducing; Adenine; Adipokines; Animals; Cells, Cultured; Core Binding Fa | 2020 |
Sodium copper chlorophyllin attenuates adenine-induced chronic kidney disease via suppression of TGF-beta and inflammatory cytokines.
Topics: Adenine; Animals; Antimutagenic Agents; Chlorophyllides; Cytokines; Dose-Response Relationship, Drug | 2020 |
Neointimal hyperplasia in the inferior vena cava of adenine-induced chronic kidney disease rats with aortocaval fistulas.
Topics: Adenine; Animals; Aorta; Arteriovenous Shunt, Surgical; Blood Urea Nitrogen; Constriction, Pathologi | 2020 |
Dietary Fermented Soy Extract and Oligo-Lactic Acid Alleviate Chronic Kidney Disease in Mice via Inhibition of Inflammation and Modulation of Gut Microbiota.
Topics: Adenine; Animals; Biomarkers; Cecum; Clostridium; Cystatin C; Cytokines; Dietary Supplements; Diseas | 2020 |
Effect of Chronic Kidney Disease on Hepatic Clearance of Drugs in Rats.
Topics: Acetaminophen; Adenine; Administration, Intravenous; Animals; Cytochrome P-450 CYP3A; Disease Models | 2020 |
Evidence of an intestinal phosphate transporter alternative to type IIb sodium-dependent phosphate transporter in rats with chronic kidney disease.
Topics: Adenine; Animals; Intestines; Male; Phosphate Transport Proteins; Phosphates; Rats; Rats, Inbred F34 | 2021 |
Maternal Adenine-Induced Chronic Kidney Disease Programs Hypertension in Adult Male Rat Offspring: Implications of Nitric Oxide and Gut Microbiome Derived Metabolites.
Topics: Adenine; Animals; Disease Models, Animal; Dysbiosis; Female; Fetal Development; Gastrointestinal Mic | 2020 |
Lack of Endothelial Nitric Oxide Synthase Accelerates Ectopic Calcification in Uremic Mice Fed an Adenine and High Phosphorus Diet.
Topics: Adenine; Animals; Aorta; Calcinosis; Diet; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Nitric Oxide | 2021 |
Knockdown of CK2α reduces
Topics: Adenine; Animals; Casein Kinase II; Cell Line; Cellular Senescence; Cresols; Disease Models, Animal; | 2020 |
The influence of the prebiotic gum acacia on the intestinal microbiome composition in rats with experimental chronic kidney disease.
Topics: Adenine; Animals; Bacteria; Butyrates; Disease Models, Animal; Dysbiosis; Female; Gastrointestinal M | 2021 |
Contribution of TFEB-mediated autophagy to tubulointerstitial fibrosis in mice with adenine-induced chronic kidney disease.
Topics: Adenine; Animals; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Line; | 2021 |
Morin hydrate attenuates adenine-induced renal fibrosis via targeting cathepsin D signaling.
Topics: Adenine; Animals; Cathepsin D; Collagen; Extracellular Matrix; Fibrosis; Flavonoids; Kidney; Kidney | 2021 |
Lindera aggregata intervents adenine-induced chronic kidney disease by mediating metabolism and TGF-β/Smad signaling pathway.
Topics: Adenine; Animals; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Fibrosis; Humans; Kid | 2021 |
Renoprotective effects of enzyme-hydrolyzed polysaccharides from Auricularia polytricha on adenine-induced chronic kidney diseases in mice.
Topics: Adenine; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; | 2021 |
Synbiotics Alleviate the Gut Indole Load and Dysbiosis in Chronic Kidney Disease.
Topics: Adenine; Aged; Animals; Bacteria; Biodiversity; Body Weight; Diet; Disease Models, Animal; Dysbiosis | 2021 |
Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice.
Topics: Adenine; Albuminuria; Animals; Cardiomegaly; Choline; Disease Models, Animal; Female; Fibroblast Gro | 2021 |
Nicotinamide Attenuates the Progression of Renal Failure in a Mouse Model of Adenine-Induced Chronic Kidney Disease.
Topics: Adenine; Animals; Citric Acid Cycle; Disease Models, Animal; Disease Progression; Energy Metabolism; | 2021 |
Experimental modulation of Interleukin 1 shows its key role in chronic kidney disease progression and anemia.
Topics: Adenine; Anemia; Animals; Antibodies, Monoclonal; Disease Models, Animal; Disease Progression; Immun | 2021 |
Strain-specific alterations in the skeletal response to adenine-induced chronic kidney disease are associated with differences in parathyroid hormone levels.
Topics: Adenine; Animals; Female; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Parathyroid Hormone; Renal Ins | 2021 |
Adenine-induced chronic kidney disease induces a similar skeletal phenotype in male and female C57BL/6 mice with more severe deficits in cortical bone properties of male mice.
Topics: Adenine; Animals; Bone and Bones; Bone Diseases, Metabolic; Cortical Bone; Diet; Disease Models, Ani | 2021 |
The synergic renoprotective effect of Rehmanniae Radix Preparata and Corni Fructus on adenine-induced chronic kidney disease rats based on integrated plasma metabolomics and network pharmacology approach.
Topics: Adenine; Animals; Cornus; Drugs, Chinese Herbal; Male; Medicine, Chinese Traditional; Metabolome; Me | 2021 |
Integrated gut microbiota and fecal metabolomics reveal the renoprotective effect of Rehmanniae Radix Preparata and Corni Fructus on adenine-induced CKD rats.
Topics: Adenine; Animals; Chromatography, High Pressure Liquid; Cornus; Drugs, Chinese Herbal; Feces; Gastro | 2021 |
The Effect of Metformin in Diabetic and Non-Diabetic Rats with Experimentally-Induced Chronic Kidney Disease.
Topics: Adenine; Animals; Diabetes Mellitus, Experimental; Kidney; MAP Kinase Signaling System; Metformin; R | 2021 |
Myeloid cell-derived coagulation tissue factor is associated with renal tubular damage in mice fed an adenine diet.
Topics: Adenine; Animals; Fibrin Fibrinogen Degradation Products; Glomerular Filtration Rate; Humans; Kidney | 2021 |
Tissue-specific expression of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2, in mouse models of chronic kidney disease.
Topics: Adenine; Angiotensin-Converting Enzyme 2; Animals; Aristolochic Acids; COVID-19; Disease Models, Ani | 2021 |
Evaluation of the impact of gut microbiota on uremic solute accumulation by a CE-TOFMS-based metabolomics approach.
Topics: Acute Kidney Injury; Adenine; Animals; Disease Models, Animal; Disease Progression; Electrophoresis, | 2017 |
Klotho restoration via acetylation of Peroxisome Proliferation-Activated Receptor γ reduces the progression of chronic kidney disease.
Topics: Acetylation; Adenine; Animals; Cell Proliferation; Disease Models, Animal; Disease Progression; Down | 2017 |
The effect of swimming exercise on adenine-induced kidney disease in rats, and the influence of curcumin or lisinopril thereon.
Topics: Adenine; Animals; Antioxidants; Blood Pressure; Creatinine; Curcumin; Disease Models, Animal; Female | 2017 |
Subclinical chronic kidney disease modifies the diagnosis of experimental acute kidney injury.
Topics: Acute Kidney Injury; Adenine; Animals; Aristolochic Acids; Biomarkers; Cell Adhesion Molecules; Chem | 2017 |
Effect of aqueous extract and anthocyanins of calyces of Hibiscus sabdariffa (Malvaceae) in rats with adenine-induced chronic kidney disease.
Topics: Adenine; Administration, Oral; Animals; Anthocyanins; Disease Models, Animal; Dose-Response Relation | 2017 |
Curcumin Ameliorates Kidney Function and Oxidative Stress in Experimental Chronic Kidney Disease.
Topics: Acute-Phase Proteins; Adenine; Animals; Antioxidants; Biomarkers; Creatinine; Curcumin; Cytokines; D | 2018 |
Targeting Oxygen-Sensing Prolyl Hydroxylase for Metformin-Associated Lactic Acidosis Treatment.
Topics: Acidosis, Lactic; Adenine; Animals; Disease Models, Animal; Enzyme Inhibitors; Gluconeogenesis; Kidn | 2017 |
Dipeptidyl peptidase-4 inhibitor gemigliptin protects against vascular calcification in an experimental chronic kidney disease and vascular smooth muscle cells.
Topics: Adenine; Animals; Aorta, Abdominal; Calcium; Core Binding Factor Alpha 1 Subunit; Dipeptidyl-Peptida | 2017 |
Chitosan-Fe (III) Complex as a Phosphate Chelator in Uraemic Rats: A Novel Treatment Option.
Topics: Adenine; Animals; Chelating Agents; Chitosan; Creatinine; Disease Models, Animal; Ferric Compounds; | 2018 |
The uremic toxin indoxyl sulfate interferes with iron metabolism by regulating hepcidin in chronic kidney disease.
Topics: Adenine; Animals; Disease Models, Animal; Gene Expression Regulation; Hep G2 Cells; Hepcidins; Human | 2018 |
Effect of adipose-derived mesenchymal stem cell transplantation on vascular calcification in rats with adenine-induced kidney disease.
Topics: Adenine; Adipocytes; Animals; Calcium; Cell- and Tissue-Based Therapy; Kidney; Male; Mesenchymal Ste | 2017 |
Endothelin A receptor blocker and calcimimetic in the adenine rat model of chronic renal insufficiency.
Topics: Adenine; Animals; Calcimimetic Agents; Cinacalcet; Disease Models, Animal; Endothelin A Receptor Ant | 2017 |
p-Cresyl sulfate decreases peripheral B cells in mice with adenine-induced renal dysfunction.
Topics: Adenine; Animals; B-Lymphocytes; Bone Marrow Cells; Cell Proliferation; Cresols; Dose-Response Relat | 2018 |
RIPK3 promotes kidney fibrosis via AKT-dependent ATP citrate lyase.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Animals; ATP Citrate (pro-S)-Lyase; Cell Differentiation; D | 2018 |
Gum Acacia Improves Renal Function and Ameliorates Systemic Inflammation, Oxidative and Nitrosative Stress in Streptozotocin-Induced Diabetes in Rats with Adenine-Induced Chronic Kidney Disease.
Topics: Acacia; Adenine; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Gum Arabic; Infla | 2018 |
The Case | Shining a light on an unusual case of chronic kidney disease.
Topics: Adenine; Adenine Phosphoribosyltransferase; Aged; Biopsy; Crystallization; Humans; Kidney; Male; Met | 2018 |
Ameliorative effect of ursolic acid on renal fibrosis in adenine-induced chronic kidney disease in rats.
Topics: Adenine; Animals; Blood Urea Nitrogen; Collagen Type I; Connective Tissue Growth Factor; Creatinine; | 2018 |
Dietary Fermentable Fibers Attenuate Chronic Kidney Disease in Mice by Protecting the Intestinal Barrier.
Topics: Adenine; Animals; Cecum; Colon; Diet; Dietary Fiber; Dysbiosis; Fatty Acids, Volatile; Fermentation; | 2018 |
Metformin prevents the development of severe chronic kidney disease and its associated mineral and bone disorder.
Topics: Adenine; Animals; Chronic Kidney Disease-Mineral and Bone Disorder; Disease Models, Animal; Humans; | 2018 |
Cellular Origin and Functional Relevance of Collagen I Production in the Kidney.
Topics: Acute Kidney Injury; Adenine; Animals; Bone Marrow Cells; Cell Lineage; Collagen Type I; Epithelial | 2018 |
Interleukin-6 contributes to the increase in fibroblast growth factor 23 expression in acute and chronic kidney disease.
Topics: Acute Kidney Injury; Adenine; Animals; Bone and Bones; Dexamethasone; Disease Models, Animal; Fibrob | 2018 |
Quercetin Treatment Improves Renal Function and Protects the Kidney in a Rat Model of Adenine-Induced Chronic Kidney Disease.
Topics: Adenine; Animals; Antioxidants; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Fibroblast | 2018 |
Identification of ABCG2 as an Exporter of Uremic Toxin Indoxyl Sulfate in Mice and as a Crucial Factor Influencing CKD Progression.
Topics: Adenine; Adenosine Triphosphate; Analysis of Variance; Animals; ATP Binding Cassette Transporter, Su | 2018 |
Characterization of the Activity and Distribution of a 2'-O-Methoxyethyl-Modified Antisense Oligonucleotide in Models of Acute and Chronic Kidney Disease.
Topics: Acute Kidney Injury; Adenine; Animals; Cell Line; Humans; Liver; Mice; Oligonucleotides, Antisense; | 2018 |
Fish Oil Supplementation Reduces Inflammation but Does Not Restore Renal Function and Klotho Expression in an Adenine-Induced CKD Model.
Topics: Adenine; Animal Feed; Animals; Biomarkers; Dietary Supplements; Disease Models, Animal; Down-Regulat | 2018 |
Deregulated iron metabolism in bone marrow from adenine-induced mouse model of chronic kidney disease.
Topics: Adenine; Animals; Bone Marrow; Cytokines; Erythropoiesis; Erythropoietin; Hepcidins; Iron; Kidney; M | 2019 |
The effect of sildenafil on rats with adenine-Induced chronic kidney disease.
Topics: Adenine; Animals; Biomarkers; Blood Pressure; Body Weight; Creatinine; Cytokines; Fibrosis; Inflamma | 2018 |
Effect of Sevelamer on Serum Levels of Klotho and Soluble Tumor Necrosis Factor-like Weak Inducer of Apoptosis in Rats With Adenine-induced Chronic Kidney Disease.
Topics: Adenine; Animals; Apoptosis; Cytokine TWEAK; Glucuronidase; Klotho Proteins; Male; Phosphates; Rats; | 2018 |
AT2 receptor stimulation inhibits phosphate-induced vascular calcification.
Topics: Adenine; Animals; Aorta, Thoracic; Aortic Diseases; Cells, Cultured; Disease Models, Animal; Humans; | 2019 |
Long-term renal outcomes of APRT deficiency presenting in childhood.
Topics: Acute Kidney Injury; Adenine; Adenine Phosphoribosyltransferase; Adolescent; Adult; Allopurinol; Chi | 2019 |
The renoprotective effect of the dipeptidyl peptidase-4 inhibitor sitagliptin on adenine-induced kidney disease in rats.
Topics: Adenine; Animals; Dipeptidyl-Peptidase IV Inhibitors; Dose-Response Relationship, Drug; Protective A | 2019 |
Removal of a gadolinium based contrast agent by a novel sorbent hemoperfusion in a chronic kidney disease (CKD) rodent model.
Topics: Adenine; Animals; Contrast Media; Disease Models, Animal; Drug Hypersensitivity; Gadolinium DTPA; He | 2019 |
TUDCA-Treated Mesenchymal Stem Cells Protect against ER Stress in the Hippocampus of a Murine Chronic Kidney Disease Model.
Topics: Adenine; Animals; Cell Line; Cell Survival; Coculture Techniques; Cresols; Disease Models, Animal; E | 2019 |
Chronic kidney disease induced by an adenine rich diet upregulates integrin linked kinase (ILK) and its depletion prevents the disease progression.
Topics: Actins; Adenine; Animals; Cadherins; Creatinine; Diet; Disease Models, Animal; Extracellular Matrix; | 2019 |
Effects of the SGLT-2 Inhibitor Canagliflozin on Adenine-Induced Chronic Kidney Disease in Rats.
Topics: Adenine; Animals; Biomarkers; Canagliflozin; Rats; Rats, Wistar; Renal Insufficiency, Chronic; Sodiu | 2019 |
Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α Inhibits Vascular Calcification Through Sirtuin 3-Mediated Reduction of Mitochondrial Oxidative Stress.
Topics: Adenine; Aged; Aged, 80 and over; Animals; Aorta, Abdominal; Cells, Cultured; Disease Models, Animal | 2019 |
Increased FGF23 protects against detrimental cardio-renal consequences during elevated blood phosphate in CKD.
Topics: Adenine; Animals; Bone and Bones; Cardio-Renal Syndrome; Disease Models, Animal; Echocardiography; F | 2019 |
Effects of lactulose on renal function and gut microbiota in adenine-induced chronic kidney disease rats.
Topics: Adenine; Animals; Bacteria; Biomarkers; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Dis | 2019 |
The effect of chronic kidney disease on CYP2B expression and activity in male Wistar rats.
Topics: Adenine; Animals; Aryl Hydrocarbon Hydroxylases; Bupropion; Cytochrome P-450 CYP2B1; Disease Models, | 2019 |
Towards minimally-invasive, quantitative assessment of chronic kidney disease using optical spectroscopy.
Topics: Adenine; Animals; Atrophy; Blood Urea Nitrogen; Diet; Disease Models, Animal; Female; Fibrosis; Kidn | 2019 |
Comparison of the Effects of Indobufen and Warfarin in a Rat Model of Adenine-Induced Chronic Kidney Disease.
Topics: Adenine; Animals; Anticoagulants; China; Disease Models, Animal; Fibrosis; Isoindoles; Kidney; Kidne | 2019 |
Mononuclear phagocytes orchestrate prolyl hydroxylase inhibition-mediated renoprotection in chronic tubulointerstitial nephritis.
Topics: Adenine; Animals; Anti-Inflammatory Agents; Basic Helix-Loop-Helix Transcription Factors; Clodronic | 2019 |
The RAGE/STAT5/autophagy axis regulates senescence in mesangial cells.
Topics: Adenine; Aging; Animals; Antigens, Neoplasm; Autophagy; Cellular Senescence; Gene Expression Regulat | 2019 |
The Kidney Clock Contributes to Timekeeping by the Master Circadian Clock.
Topics: Adenine; Animals; Circadian Clocks; Disease Models, Animal; Kidney; Male; Mice, Inbred C57BL; Period | 2019 |
In Vitro and In Vivo Renoprotective Effects of Telbivudine in Chronic Hepatitis B Patients Receiving Nucleotide Analogue.
Topics: Activating Transcription Factor 4; Adenine; Antiviral Agents; Apoptosis; Caspase 12; Cell Line; Cell | 2019 |
Vitamin D-regulated osteocytic sclerostin and BMP2 modulate uremic extraskeletal calcification.
Topics: 25-Hydroxyvitamin D3 1-alpha-Hydroxylase; Adaptor Proteins, Signal Transducing; Adenine; Animals; Bl | 2019 |
Ultra performance liquid chromatography-based metabonomic study of therapeutic effect of the surface layer of Poria cocos on adenine-induced chronic kidney disease provides new insight into anti-fibrosis mechanism.
Topics: Adenine; Animals; Biomarkers; Chromatography, High Pressure Liquid; Fibrosis; Male; Mass Spectrometr | 2013 |
Osteogenesis of heterotopically transplanted mesenchymal stromal cells in rat models of chronic kidney disease.
Topics: Adenine; Animals; Aorta; Biomarkers; Bone Morphogenetic Proteins; Calcification, Physiologic; Cell D | 2013 |
Role of traditional risk factors and antiretroviral drugs in the incidence of chronic kidney disease, ANRS CO3 Aquitaine cohort, France, 2004-2012.
Topics: Adenine; Age Factors; Anti-Retroviral Agents; Cohort Studies; Contraindications; Female; France; Glo | 2013 |
Tubular and glomerular proteinuria in HIV-infected adults with estimated glomerular filtration rate ≥ 60 ml/min per 1.73 m2.
Topics: Adenine; Adult; Aged; Anti-HIV Agents; Cross-Sectional Studies; Female; Glomerular Filtration Rate; | 2013 |
Transforming growth factor-β1-mediated renal fibrosis is dependent on the regulation of transforming growth factor receptor 1 expression by let-7b.
Topics: 3' Untranslated Regions; Adenine; Animals; Apolipoproteins E; Binding Sites; Cell Line; Diabetic Nep | 2014 |
Rosiglitazone alleviates injury in rats with adenine‑induced chronic kidney disease.
Topics: Adenine; Animals; Creatinine; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Kidney Functio | 2013 |
WHO antiretroviral therapy guidelines 2010 and impact of tenofovir on chronic kidney disease in Vietnamese HIV-infected patients.
Topics: Adenine; Adult; Anti-HIV Agents; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Organop | 2013 |
Glibenclamide improves kidney and heart structure and function in the adenine-diet model of chronic kidney disease.
Topics: Adenine; Animals; Aorta, Thoracic; Blood Pressure; Carrier Proteins; Diet; Glyburide; Heart; Heme Ox | 2014 |
Assessment with unenhanced MRI techniques of renal morphology and hemodynamic changes during acute kidney injury and chronic kidney disease in mice.
Topics: Acute Kidney Injury; Adenine; Animals; Contrast Media; Hemodynamics; Kidney; Kidney Diseases; Magnet | 2014 |
Hyperphosphatemia induces protective autophagy in endothelial cells through the inhibition of Akt/mTOR signaling.
Topics: Adenine; Animals; Autophagy; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; En | 2015 |
Phosphate overload directly induces systemic inflammation and malnutrition as well as vascular calcification in uremia.
Topics: Acute-Phase Proteins; Adenine; Animals; Blood Pressure; Cells, Cultured; Disease Models, Animal; Dos | 2014 |
Mineral bone disorder in chronic kidney disease: head-to-head comparison of the 5/6 nephrectomy and adenine models.
Topics: Adenine; Animals; Bone Diseases, Metabolic; Calcification, Physiologic; Calcium; Disease Models, Ani | 2014 |
A chronic kidney disease risk score to determine tenofovir safety in a prospective cohort of HIV-positive male veterans.
Topics: Adenine; Adult; Anti-HIV Agents; Cohort Studies; HIV Infections; Humans; Male; Middle Aged; Organoph | 2014 |
Does swimming exercise affect experimental chronic kidney disease in rats treated with gum acacia?
Topics: Adenine; Animals; Dietary Supplements; Exercise Therapy; Gum Arabic; Kidney; Male; Rats; Rats, Wista | 2014 |
Calcification of the internal pudendal artery and development of erectile dysfunction in adenine-induced chronic kidney disease: a sentinel of systemic vascular changes.
Topics: Adenine; Animals; Arteries; Calcium; Erectile Dysfunction; Male; Pelvis; Penile Erection; Penis; Pho | 2014 |
Gender differences in adenine-induced chronic kidney disease and cardiovascular complications in rats.
Topics: Adenine; Animals; Blood Pressure; Cardiovascular Diseases; Estrogens; Female; In Vitro Techniques; K | 2014 |
Effect of erythropoietin on hepatic cytochrome P450 expression and function in an adenine-fed rat model of chronic kidney disease.
Topics: Adenine; Animals; Constitutive Androstane Receptor; Cytochrome P-450 Enzyme System; Diet; Disease Mo | 2015 |
The slowing down of renal deterioration but acceleration of cardiac hypertrophy: is the estrogen receptor-α a hero or villain?
Topics: Adenine; Animals; Cardiovascular Diseases; Female; Male; Renal Insufficiency, Chronic | 2014 |
Peritoneal fibrosis induced by intraperitoneal methylglyoxal injection: the role of concurrent renal dysfunction.
Topics: Adenine; Animals; Body Weight; Kidney Function Tests; Matrix Metalloproteinase 2; Peritoneal Fibrosi | 2014 |
Phosphate binders prevent phosphate-induced cellular senescence of vascular smooth muscle cells and vascular calcification in a modified, adenine-based uremic rat model.
Topics: Adenine; Animal Feed; Animals; Calcinosis; Calcium Carbonate; Cellular Senescence; Disease Models, A | 2015 |
Diminished impact of ethnicity as a risk factor for chronic kidney disease in the current HIV treatment era.
Topics: Adenine; Adult; Africa South of the Sahara; Anti-HIV Agents; Cross-Sectional Studies; Female; HIV In | 2015 |
Influence of treatment with gum acacia on renal vascular responses in a rat model of chronic kidney disease.
Topics: Adenine; Animals; Creatinine; Disease Models, Animal; Gum Arabic; Kidney; Kidney Function Tests; Mal | 2015 |
Reduction of NO-mediated Relaxing Effects in the Thoracic Aorta in an Experimental Chronic Kidney Disease Mouse Model.
Topics: Acetylcholine; Adenine; Animals; Aorta, Thoracic; Disease Models, Animal; Male; Mice; Mice, Inbred C | 2015 |
Ameliorative effect of chrysin on adenine-induced chronic kidney disease in rats.
Topics: Acetylglucosaminidase; Adenine; Animals; Antioxidants; Creatinine; Disease Models, Animal; Fibrosis; | 2015 |
Spironolactone ameliorates arterial medial calcification in uremic rats: the role of mineralocorticoid receptor signaling in vascular calcification.
Topics: Adenine; Animals; Aorta, Abdominal; Aortic Diseases; Apoptosis; Biomarkers; Disease Models, Animal; | 2015 |
Magnesium Modifies the Impact of Calcitriol Treatment on Vascular Calcification in Experimental Chronic Kidney Disease.
Topics: Adenine; Animals; Aorta, Abdominal; Calcitriol; Calcium; Calcium Channel Agonists; Carotid Arteries; | 2015 |
Therapeutic Effect of Chrysin on Adenine-Induced Chronic Kidney Disease in Rats.
Topics: Acute-Phase Proteins; Adenine; Administration, Oral; Animals; Antioxidants; Biomarkers; Catalase; Cr | 2016 |
Effect of diesel exhaust particles on renal vascular responses in rats with chronic kidney disease.
Topics: Adenine; Animals; Blood Pressure; Immunohistochemistry; Kidney; Lung; Male; Particulate Matter; Phen | 2017 |
Pharmacokinetics and Safety of Tenofovir Alafenamide in HIV-Uninfected Subjects with Severe Renal Impairment.
Topics: Adenine; Aged; Alanine; Anti-HIV Agents; Area Under Curve; Case-Control Studies; Female; Glomerular | 2016 |
Renal cellular hypoxia in adenine-induced chronic kidney disease.
Topics: Adenine; Animals; Cell Hypoxia; Kidney; Male; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chron | 2016 |
Lack of hepcidin ameliorates anemia and improves growth in an adenine-induced mouse model of chronic kidney disease.
Topics: Adenine; Anemia; Animals; Disease Models, Animal; Femur; Fibroblast Growth Factor-23; Growth Disorde | 2016 |
Rhein reverses Klotho repression via promoter demethylation and protects against kidney and bone injuries in mice with chronic kidney disease.
Topics: Adenine; Animals; Anthraquinones; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA | 2017 |
Effects of dietary iron intake and chronic kidney disease on fibroblast growth factor 23 metabolism in wild-type and hepcidin knockout mice.
Topics: Adenine; Animals; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Hepcidins; Iron, Dietary; | 2016 |
Metabolomics insights into activated redox signaling and lipid metabolism dysfunction in chronic kidney disease progression.
Topics: Adenine; Animals; Aristolochic Acids; Biomarkers; Disease Models, Animal; Disease Progression; Early | 2016 |
Inhibition of GSK-3β increases trabecular bone volume but not cortical bone volume in adenine-induced uremic mice with severe hyperparathyroidism.
Topics: Adenine; Animals; Cancellous Bone; Cortical Bone; Fractures, Bone; Glycogen Synthase Kinase 3; Glyco | 2016 |
Vitamin K Metabolism in a Rat Model of Chronic Kidney Disease.
Topics: Adenine; Animals; Aorta, Thoracic; Carbon-Carbon Ligases; Dimethylallyltranstransferase; Disease Mod | 2017 |
Circulating kidney injury molecule-1 is a novel diagnostic biomarker for renal dysfunction during long-term adefovir therapy in chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Biomarkers; Cohort Studies; Female; Hepatitis A Virus Cellular Rec | 2016 |
Increased serum hepcidin contributes to the anemia of chronic kidney disease in a murine model.
Topics: Adenine; Anemia; Animals; Blood Urea Nitrogen; Diet; Disease Models, Animal; Erythropoietin; Gene Ex | 2017 |
Carbamylated Low-Density Lipoprotein (cLDL)-Mediated Induction of Autophagy and Its Role in Endothelial Cell Injury.
Topics: Adenine; Atherosclerosis; Autophagosomes; Autophagy; Autophagy-Related Protein 5; Beclin-1; Cell Dea | 2016 |
The in vivo effects of adenine-induced chronic kidney disease on some renal and hepatic function and CYP450 metabolizing enzymes.
Topics: Adenine; Animals; Cytochrome P-450 Enzyme System; Disease Models, Animal; Kidney; Liver; Male; Pharm | 2017 |
Protease-activated receptor 2 exacerbates adenine-induced renal tubulointerstitial injury in mice.
Topics: Adenine; Animals; Enzyme-Linked Immunosorbent Assay; Factor V; Factor Xa; Fibrin; Fibrosis; Gene Exp | 2017 |
Adenine Rich Diet Is Not a Surrogate of 5/6 Nephrectomy in Rabbits.
Topics: Adenine; Animals; Creatinine; Diet; Disease Models, Animal; Glomerular Filtration Rate; Kidney; Male | 2017 |
[Marine collagen peptide slow down the progression of chronic renal function impairment induced by adenine in rats].
Topics: Adenine; Animals; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Marine B | 2008 |
Abacavir use and risk of acute myocardial infarction and cerebrovascular events in the highly active antiretroviral therapy era.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Dideoxynucleosides; Female; HIV Inf | 2011 |
Chronic exposure to environmental contaminant nonylphenol exacerbates adenine-induced chronic renal insufficiency: role of signaling pathways and therapeutic impact of rosuvastatin.
Topics: Adenine; Animals; Biomarkers; Blood Urea Nitrogen; Body Weight; Creatinine; Cytoprotection; Disease | 2012 |
Renal toxicity of long-term therapy with tenofovir in HIV-infected patients.
Topics: Adenine; Adult; Anti-HIV Agents; Dideoxynucleosides; Disease Progression; Female; Follow-Up Studies; | 2012 |
Renal function and incidence of chronic kidney disease in HIV patients: a Danish cohort study.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Cohort S | 2012 |
Continuing exposure to low-dose nonylphenol aggravates adenine-induced chronic renal dysfunction and role of rosuvastatin therapy.
Topics: Adenine; Animals; Apoptosis; Biomarkers; Blood Urea Nitrogen; Creatinine; Environmental Exposure; Fl | 2012 |
Risk factors for chronic kidney disease in a large cohort of HIV-1 infected individuals initiating antiretroviral therapy in routine care.
Topics: Adenine; Adult; AIDS-Associated Nephropathy; Anti-HIV Agents; CD4 Lymphocyte Count; Cohort Studies; | 2012 |
Tenofovir-associated proteinuria.
Topics: Adenine; Anti-HIV Agents; Creatine; Female; HIV Infections; Humans; Male; Middle Aged; Organophospho | 2013 |
Cardiovascular disease in an adenine-induced model of chronic kidney disease: the temporal link between vascular calcification and haemodynamic consequences.
Topics: Adenine; Animals; Blood Pressure; Cardiovascular Diseases; Disease Models, Animal; Hemodynamics; Mal | 2013 |
Intrarenal metabolomic investigation of chronic kidney disease and its TGF-β1 mechanism in induced-adenine rats using UPLC Q-TOF/HSMS/MS(E).
Topics: Adenine; Animals; Chromatography, High Pressure Liquid; Cresols; Fatty Acids, Unsaturated; Fibrosis; | 2013 |
Tenofovir treatment duration predicts proteinuria in a multiethnic United States Cohort of children and adolescents with perinatal HIV-1 infection.
Topics: Adenine; Adolescent; Anti-HIV Agents; Black or African American; Child; Cohort Studies; Female; Hisp | 2013 |
Dietary vitamin K and therapeutic warfarin alter the susceptibility to vascular calcification in experimental chronic kidney disease.
Topics: Adenine; Animals; Anticoagulants; Arteries; Biomarkers; Blood Pressure; Dietary Supplements; Disease | 2013 |
Thalidomide suppresses inflammation in adenine-induced CKD with uraemia in mice.
Topics: Adenine; Animals; Blotting, Western; Cytokines; Disease Models, Animal; Electrophoretic Mobility Shi | 2013 |
Effect of manipulating serum phosphorus with phosphate binder on circulating PTH and FGF23 in renal failure rats.
Topics: Adenine; Animals; Blood Urea Nitrogen; Body Weight; Calcitriol; Calcium; Creatinine; Diet; Eating; F | 2006 |