adenine has been researched along with Precursor Cell Lymphoblastic Leukemia-Lymphoma in 10 studies
Precursor Cell Lymphoblastic Leukemia-Lymphoma: A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
| Excerpt | Relevance | Reference |
|---|---|---|
| "After Phase I studies of benzisoquinolinedione (amonafide) in solid tumors identified myelosuppression as the dose-limiting toxicity, we conducted a Phase I study in patients with relapsed or refractory acute leukemia to define the optimal dose." | 9.07 | Phase I clinical investigation of benzisoquinolinedione (amonafide) in adults with refractory or relapsed acute leukemia. ( Benvenuto, JA; Beran, M; Estey, E; Felder, TB; Keating, M; O'Brien, S, 1991) |
| "After Phase I studies of benzisoquinolinedione (amonafide) in solid tumors identified myelosuppression as the dose-limiting toxicity, we conducted a Phase I study in patients with relapsed or refractory acute leukemia to define the optimal dose." | 5.07 | Phase I clinical investigation of benzisoquinolinedione (amonafide) in adults with refractory or relapsed acute leukemia. ( Benvenuto, JA; Beran, M; Estey, E; Felder, TB; Keating, M; O'Brien, S, 1991) |
| "Acute lymphoblastic leukemia (ALL) typically originates from pre-B cells that critically depend on survival signals emanating from a functional pre-BCR." | 2.52 | Rationale for targeting the pre-B-cell receptor signaling pathway in acute lymphoblastic leukemia. ( Müschen, M, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 3 (30.00) | 2.80 |
| Authors | Studies |
|---|---|
| Godwin, CD | 1 |
| Bates, OM | 1 |
| Garling, EE | 1 |
| Beddoe, ME | 1 |
| Laszlo, GS | 1 |
| Walter, RB | 1 |
| Carlos, JAEG | 1 |
| Lima, K | 1 |
| Costa-Lotufo, LV | 1 |
| Leitão, A | 1 |
| Machado-Neto, JA | 1 |
| Butler, M | 1 |
| van Ingen Schenau, DS | 1 |
| Yu, J | 1 |
| Jenni, S | 1 |
| Dobay, MP | 1 |
| Hagelaar, R | 1 |
| Vervoort, BMT | 1 |
| Tee, TM | 1 |
| Hoff, FW | 1 |
| Meijerink, JP | 1 |
| Kornblau, SM | 1 |
| Bornhauser, B | 1 |
| Bourquin, JP | 1 |
| Kuiper, RP | 1 |
| van der Meer, LT | 1 |
| van Leeuwen, FN | 1 |
| Hu, YY | 1 |
| Tao, SD | 1 |
| Ma, JJ | 1 |
| Zhou, LT | 1 |
| Chen, Y | 1 |
| Yu, L | 1 |
| Li, Z | 1 |
| Wu, J | 1 |
| Sheng, L | 1 |
| Müschen, M | 1 |
| Xia, T | 1 |
| Wang, J | 1 |
| Wang, Y | 2 |
| Cai, J | 1 |
| Wang, M | 1 |
| Chen, Q | 1 |
| Song, J | 1 |
| Yu, Z | 1 |
| Huang, W | 1 |
| Fang, J | 1 |
| Barnes, MJ | 1 |
| Taylor, GA | 1 |
| Newell, DR | 1 |
| Gilbertsen, RB | 1 |
| Dong, MK | 1 |
| Kossarek, LM | 1 |
| Sircar, JC | 1 |
| Kostlan, CR | 1 |
| Conroy, MC | 1 |
| O'Brien, S | 1 |
| Benvenuto, JA | 1 |
| Estey, E | 1 |
| Beran, M | 1 |
| Felder, TB | 1 |
| Keating, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Proof-of-concept Study of Ibrutinib in c-MYC and HER2 Amplified Oesophagogastric Carcinoma[NCT02884453] | Phase 2 | 17 participants (Anticipated) | Interventional | 2016-07-19 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for adenine and Precursor Cell Lymphoblastic Leukemia-Lymphoma
| Article | Year |
|---|---|
Rationale for targeting the pre-B-cell receptor signaling pathway in acute lymphoblastic leukemia.
Topics: Adenine; DNA-Binding Proteins; Humans; Molecular Targeted Therapy; Piperidines; Pre-B Cell Receptors | 2015 |
2 trials available for adenine and Precursor Cell Lymphoblastic Leukemia-Lymphoma
| Article | Year |
|---|---|
BTK inhibition sensitizes acute lymphoblastic leukemia to asparaginase by suppressing the amino acid response pathway.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Amino Acids; Animals; Antineoplastic Agents; Apoptosis | 2021 |
Phase I clinical investigation of benzisoquinolinedione (amonafide) in adults with refractory or relapsed acute leukemia.
Topics: Acute Disease; Adenine; Adult; Aged; Antineoplastic Agents; Drug Administration Schedule; Drug Evalu | 1991 |
7 other studies available for adenine and Precursor Cell Lymphoblastic Leukemia-Lymphoma
| Article | Year |
|---|---|
The Bruton's tyrosine kinase inhibitor ibrutinib abrogates bispecific antibody-mediated T-cell cytotoxicity.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Antibodies, Bispecific; Antineoplastic Agents, Immunol | 2020 |
AD80, a multikinase inhibitor, exhibits antineoplastic effects in acute leukemia cellular models targeting the PI3K/STMN1 axis.
Topics: Adenine; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Cell Proliferation; Cell Su | 2021 |
[SDF-1α/CXCR4 Mediated Drug Resistance Can be Reversed by Ibrutinib in Acute Lymphoblastic Leukemia].
Topics: Adenine; Chemokine CXCL12; Drug Resistance, Neoplasm; Humans; Piperidines; Precursor Cell Lymphoblas | 2017 |
Ibrutinib improves the development of acute lymphoblastic leukemia by activating endoplasmic reticulum stress-induced cell death.
Topics: Activating Transcription Factor 4; Adenine; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Survival; E | 2018 |
Inhibition of autophagy potentiates anticancer property of 20(S)-ginsenoside Rh2 by promoting mitochondria-dependent apoptosis in human acute lymphoblastic leukaemia cells.
Topics: Adenine; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Autophagy-Related Protein 5; Cell | 2016 |
Development of a whole cell assay to measure methotrexate-induced inhibition of thymidylate synthase and de novo purine synthesis in leukaemia cells.
Topics: Adenine; Antimetabolites, Antineoplastic; Child; Guanine; Humans; Inosine; Leukemia; Methotrexate; P | 2000 |
Selective in vitro inhibition of human MOLT-4 T lymphoblasts by the novel purine nucleoside phosphorylase inhibitor, CI-972.
Topics: Adenine; Cell Division; Deoxycytidine; Deoxyguanine Nucleotides; DNA Replication; Guanosine Triphosp | 1991 |