adenine has been researched along with Nerve Degeneration in 21 studies
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "During prion disease, an increase in misfolded prion protein (PrP) generated by prion replication leads to sustained overactivation of the branch of the unfolded protein response (UPR) that controls the initiation of protein synthesis." | 1.39 | Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice. ( Axten, JM; Barrett, DA; Fischer, PM; Halliday, M; Mallucci, GR; Molloy, C; Moreno, JA; Ortori, CA; Radford, H; Verity, N; Willis, AE, 2013) |
| "Focal cerebral infarction was induced by distal middle cerebral artery occlusion (MCAO)." | 1.38 | Beclin 1 knockdown inhibits autophagic activation and prevents the secondary neurodegenerative damage in the ipsilateral thalamus following focal cerebral infarction. ( Dang, C; Fan, Y; Li, C; Li, J; Li, Y; Pei, Z; Xing, S; Yu, J; Zeng, J; Zhang, J; Zhang, Y, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.76) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (19.05) | 29.6817 |
| 2010's | 15 (71.43) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Guo, Q | 1 |
| Wang, B | 1 |
| Wang, X | 1 |
| Smith, WW | 1 |
| Zhu, Y | 1 |
| Liu, Z | 1 |
| Grande, V | 1 |
| Ornaghi, F | 1 |
| Comerio, L | 1 |
| Restelli, E | 1 |
| Masone, A | 1 |
| Corbelli, A | 1 |
| Tolomeo, D | 1 |
| Capone, V | 1 |
| Axten, JM | 2 |
| Laping, NJ | 1 |
| Fiordaliso, F | 1 |
| Sallese, M | 1 |
| Chiesa, R | 1 |
| Xia, DY | 1 |
| Li, W | 1 |
| Qian, HR | 1 |
| Yao, S | 1 |
| Liu, JG | 1 |
| Qi, XK | 1 |
| Scheper, W | 1 |
| Hoozemans, JJ | 1 |
| Moreno, JA | 1 |
| Halliday, M | 1 |
| Molloy, C | 1 |
| Radford, H | 1 |
| Verity, N | 1 |
| Ortori, CA | 1 |
| Willis, AE | 1 |
| Fischer, PM | 1 |
| Barrett, DA | 1 |
| Mallucci, GR | 1 |
| Kitaoka, Y | 1 |
| Munemasa, Y | 1 |
| Kojima, K | 1 |
| Hirano, A | 1 |
| Ueno, S | 1 |
| Takagi, H | 1 |
| Jones, B | 1 |
| Beaulieu-Boire, I | 1 |
| Fox, SH | 1 |
| McCarthy, A | 1 |
| McKinley, J | 1 |
| Lynch, T | 1 |
| Li, IH | 1 |
| Ma, KH | 1 |
| Kao, TJ | 1 |
| Lin, YY | 1 |
| Weng, SJ | 1 |
| Yen, TY | 1 |
| Chen, LC | 1 |
| Huang, YS | 1 |
| Park, HK | 1 |
| Chu, K | 1 |
| Jung, KH | 1 |
| Lee, ST | 1 |
| Bahn, JJ | 1 |
| Kim, M | 1 |
| Lee, SK | 1 |
| Roh, JK | 1 |
| Steiger-Barraissoul, S | 1 |
| Rami, A | 1 |
| Pinna, A | 1 |
| Tronci, E | 1 |
| Schintu, N | 2 |
| Simola, N | 1 |
| Volpini, R | 1 |
| Pontis, S | 1 |
| Cristalli, G | 1 |
| Morelli, M | 2 |
| Sadasivan, S | 1 |
| Zhang, Z | 1 |
| Larner, SF | 1 |
| Liu, MC | 1 |
| Zheng, W | 1 |
| Kobeissy, FH | 1 |
| Hayes, RL | 1 |
| Wang, KK | 1 |
| Koch, JC | 1 |
| Knöferle, J | 1 |
| Tönges, L | 1 |
| Ostendorf, T | 1 |
| Bähr, M | 1 |
| Lingor, P | 1 |
| Frau, L | 1 |
| Borsini, F | 1 |
| Wardas, J | 1 |
| Khairnar, AS | 1 |
| Xing, S | 1 |
| Zhang, Y | 1 |
| Li, J | 1 |
| Zhang, J | 1 |
| Li, Y | 1 |
| Dang, C | 1 |
| Li, C | 1 |
| Fan, Y | 1 |
| Yu, J | 1 |
| Pei, Z | 1 |
| Zeng, J | 1 |
| Graça, CR | 1 |
| Paschoal, VD | 1 |
| Cordeiro-Soubhia, RM | 1 |
| Tonelli-Nardi, SM | 1 |
| Machado, RL | 1 |
| Kouyoumdjian, JA | 1 |
| Baptista Rossit, AR | 1 |
| Kira, Y | 1 |
| Nishikawa, M | 1 |
| Ochi, A | 1 |
| Sato, E | 1 |
| Inoue, M | 1 |
| Yang, Y | 1 |
| Fukui, K | 1 |
| Koike, T | 1 |
| Zheng, X | 1 |
| Kozik, M | 1 |
21 other studies available for adenine and Nerve Degeneration
| Article | Year |
|---|---|
Activation of Nrf2 in Astrocytes Suppressed PD-Like Phenotypes via Antioxidant and Autophagy Pathways in Rat and Drosophila Models.
Topics: Adenine; Animals; Animals, Genetically Modified; Antioxidants; Antiparkinson Agents; Astrocytes; Aut | 2021 |
PERK inhibition delays neurodegeneration and improves motor function in a mouse model of Marinesco-Sjögren syndrome.
Topics: Adenine; Animals; Cerebellum; Disease Models, Animal; eIF-2 Kinase; Endoplasmic Reticulum; Guanine N | 2018 |
Ischemia preconditioning is neuroprotective in a rat cerebral ischemic injury model through autophagy activation and apoptosis inhibition.
Topics: Adenine; Animals; Apoptosis; Autophagy; Brain Ischemia; Caspase 3; Cerebrum; Immunosuppressive Agent | 2013 |
A new PERKspective on neurodegeneration.
Topics: Adenine; Alzheimer Disease; Animals; eIF-2 Kinase; Female; Humans; Indoles; Male; Memory Disorders; | 2013 |
Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice.
Topics: Adenine; Administration, Oral; Animals; Blood-Brain Barrier; Brain; eIF-2 Kinase; Eukaryotic Initiat | 2013 |
Axonal protection by Nmnat3 overexpression with involvement of autophagy in optic nerve degeneration.
Topics: Adenine; Animals; Autophagy; Axons; Cell Line; Green Fluorescent Proteins; Heat-Shock Proteins; Intr | 2013 |
Neurodegenerative disease: Neurodegeneration halted with oral therapy in mice.
Topics: Adenine; Animals; Indoles; Nerve Degeneration; Prion Diseases; Unfolded Protein Response | 2013 |
New methods of preventing neurodegeneration? Lessons from prion diseases.
Topics: Adenine; Animals; Indoles; Nerve Degeneration; Prion Diseases; Unfolded Protein Response | 2014 |
Putting the downstream breaks on neurodegeneration?
Topics: Adenine; Animals; Indoles; Nerve Degeneration; Prion Diseases; Unfolded Protein Response | 2014 |
Involvement of autophagy upregulation in 3,4-methylenedioxymethamphetamine ('ecstasy')-induced serotonergic neurotoxicity.
Topics: Adenine; Animals; Autophagy; Benzylamines; Brain Stem; Cells, Cultured; Citalopram; Dose-Response Re | 2016 |
Autophagy is involved in the ischemic preconditioning.
Topics: Adenine; Animals; Autophagy; Cathepsin D; Cell Survival; HSP70 Heat-Shock Proteins; Hypoxia-Ischemia | 2009 |
Serum deprivation induced autophagy and predominantly an AIF-dependent apoptosis in hippocampal HT22 neurons.
Topics: Adenine; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autopha | 2009 |
A new ethyladenine antagonist of adenosine A(2A) receptors: behavioral and biochemical characterization as an antiparkinsonian drug.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adenine; Animals; Antiparkinson Agents; Autoradiograph | 2010 |
Acute NMDA toxicity in cultured rat cerebellar granule neurons is accompanied by autophagy induction and late onset autophagic cell death phenotype.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Caspase 3; Cell Death; Cells, | 2010 |
Acute axonal degeneration in vivo is attenuated by inhibition of autophagy in a calcium-dependent manner.
Topics: Adenine; Animals; Autophagy; Axons; Calcium; Humans; MCF-7 Cells; Nerve Crush; Nerve Degeneration; O | 2010 |
Neuroprotective and anti-inflammatory effects of the adenosine A(2A) receptor antagonist ST1535 in a MPTP mouse model of Parkinson's disease.
Topics: Adenine; Adenosine A2 Receptor Antagonists; Animals; Anti-Inflammatory Agents; Brain; Immunohistoche | 2011 |
Beclin 1 knockdown inhibits autophagic activation and prevents the secondary neurodegenerative damage in the ipsilateral thalamus following focal cerebral infarction.
Topics: Adenine; Amyloid beta-Peptides; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin | 2012 |
NINJURIN1 single nucleotide polymorphism and nerve damage in leprosy.
Topics: Adenine; Adult; Aged; Alanine; Alleles; Asparagine; Case-Control Studies; Cell Adhesion Molecules, N | 2012 |
L-carnitine suppresses the onset of neuromuscular degeneration and increases the life span of mice with familial amyotrophic lateral sclerosis.
Topics: Adenine; Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Carnitine; Disease Progression; Female; | 2006 |
Induction of autophagy in neurite degeneration of mouse superior cervical ganglion neurons.
Topics: Adenine; Amino Acid Chloromethyl Ketones; Animals; Apoptosis Regulatory Proteins; Autophagy; Autopha | 2007 |
Degenerative changes of neurocytes in the light of autoradiographic investigations.
Topics: Adenine; Amino Acids; Animals; Autoradiography; Brain; Carbon Isotopes; Cerebral Cortex; Disease Mod | 1971 |