Page last updated: 2024-10-16

adenine and Nerve Degeneration

adenine has been researched along with Nerve Degeneration in 21 studies

Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.

Research Excerpts

ExcerptRelevanceReference
"During prion disease, an increase in misfolded prion protein (PrP) generated by prion replication leads to sustained overactivation of the branch of the unfolded protein response (UPR) that controls the initiation of protein synthesis."1.39Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice. ( Axten, JM; Barrett, DA; Fischer, PM; Halliday, M; Mallucci, GR; Molloy, C; Moreno, JA; Ortori, CA; Radford, H; Verity, N; Willis, AE, 2013)
"Focal cerebral infarction was induced by distal middle cerebral artery occlusion (MCAO)."1.38Beclin 1 knockdown inhibits autophagic activation and prevents the secondary neurodegenerative damage in the ipsilateral thalamus following focal cerebral infarction. ( Dang, C; Fan, Y; Li, C; Li, J; Li, Y; Pei, Z; Xing, S; Yu, J; Zeng, J; Zhang, J; Zhang, Y, 2012)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.76)18.7374
1990's0 (0.00)18.2507
2000's4 (19.05)29.6817
2010's15 (71.43)24.3611
2020's1 (4.76)2.80

Authors

AuthorsStudies
Guo, Q1
Wang, B1
Wang, X1
Smith, WW1
Zhu, Y1
Liu, Z1
Grande, V1
Ornaghi, F1
Comerio, L1
Restelli, E1
Masone, A1
Corbelli, A1
Tolomeo, D1
Capone, V1
Axten, JM2
Laping, NJ1
Fiordaliso, F1
Sallese, M1
Chiesa, R1
Xia, DY1
Li, W1
Qian, HR1
Yao, S1
Liu, JG1
Qi, XK1
Scheper, W1
Hoozemans, JJ1
Moreno, JA1
Halliday, M1
Molloy, C1
Radford, H1
Verity, N1
Ortori, CA1
Willis, AE1
Fischer, PM1
Barrett, DA1
Mallucci, GR1
Kitaoka, Y1
Munemasa, Y1
Kojima, K1
Hirano, A1
Ueno, S1
Takagi, H1
Jones, B1
Beaulieu-Boire, I1
Fox, SH1
McCarthy, A1
McKinley, J1
Lynch, T1
Li, IH1
Ma, KH1
Kao, TJ1
Lin, YY1
Weng, SJ1
Yen, TY1
Chen, LC1
Huang, YS1
Park, HK1
Chu, K1
Jung, KH1
Lee, ST1
Bahn, JJ1
Kim, M1
Lee, SK1
Roh, JK1
Steiger-Barraissoul, S1
Rami, A1
Pinna, A1
Tronci, E1
Schintu, N2
Simola, N1
Volpini, R1
Pontis, S1
Cristalli, G1
Morelli, M2
Sadasivan, S1
Zhang, Z1
Larner, SF1
Liu, MC1
Zheng, W1
Kobeissy, FH1
Hayes, RL1
Wang, KK1
Koch, JC1
Knöferle, J1
Tönges, L1
Ostendorf, T1
Bähr, M1
Lingor, P1
Frau, L1
Borsini, F1
Wardas, J1
Khairnar, AS1
Xing, S1
Zhang, Y1
Li, J1
Zhang, J1
Li, Y1
Dang, C1
Li, C1
Fan, Y1
Yu, J1
Pei, Z1
Zeng, J1
Graça, CR1
Paschoal, VD1
Cordeiro-Soubhia, RM1
Tonelli-Nardi, SM1
Machado, RL1
Kouyoumdjian, JA1
Baptista Rossit, AR1
Kira, Y1
Nishikawa, M1
Ochi, A1
Sato, E1
Inoue, M1
Yang, Y1
Fukui, K1
Koike, T1
Zheng, X1
Kozik, M1

Other Studies

21 other studies available for adenine and Nerve Degeneration

ArticleYear
Activation of Nrf2 in Astrocytes Suppressed PD-Like Phenotypes via Antioxidant and Autophagy Pathways in Rat and Drosophila Models.
    Cells, 2021, 07-21, Volume: 10, Issue:8

    Topics: Adenine; Animals; Animals, Genetically Modified; Antioxidants; Antiparkinson Agents; Astrocytes; Aut

2021
PERK inhibition delays neurodegeneration and improves motor function in a mouse model of Marinesco-Sjögren syndrome.
    Human molecular genetics, 2018, 07-15, Volume: 27, Issue:14

    Topics: Adenine; Animals; Cerebellum; Disease Models, Animal; eIF-2 Kinase; Endoplasmic Reticulum; Guanine N

2018
Ischemia preconditioning is neuroprotective in a rat cerebral ischemic injury model through autophagy activation and apoptosis inhibition.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2013, Volume: 46, Issue:7

    Topics: Adenine; Animals; Apoptosis; Autophagy; Brain Ischemia; Caspase 3; Cerebrum; Immunosuppressive Agent

2013
A new PERKspective on neurodegeneration.
    Science translational medicine, 2013, Oct-09, Volume: 5, Issue:206

    Topics: Adenine; Alzheimer Disease; Animals; eIF-2 Kinase; Female; Humans; Indoles; Male; Memory Disorders;

2013
Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice.
    Science translational medicine, 2013, Oct-09, Volume: 5, Issue:206

    Topics: Adenine; Administration, Oral; Animals; Blood-Brain Barrier; Brain; eIF-2 Kinase; Eukaryotic Initiat

2013
Axonal protection by Nmnat3 overexpression with involvement of autophagy in optic nerve degeneration.
    Cell death & disease, 2013, Oct-17, Volume: 4

    Topics: Adenine; Animals; Autophagy; Axons; Cell Line; Green Fluorescent Proteins; Heat-Shock Proteins; Intr

2013
Neurodegenerative disease: Neurodegeneration halted with oral therapy in mice.
    Nature reviews. Neurology, 2013, Volume: 9, Issue:12

    Topics: Adenine; Animals; Indoles; Nerve Degeneration; Prion Diseases; Unfolded Protein Response

2013
New methods of preventing neurodegeneration? Lessons from prion diseases.
    Movement disorders : official journal of the Movement Disorder Society, 2014, Volume: 29, Issue:1

    Topics: Adenine; Animals; Indoles; Nerve Degeneration; Prion Diseases; Unfolded Protein Response

2014
Putting the downstream breaks on neurodegeneration?
    Movement disorders : official journal of the Movement Disorder Society, 2014, Volume: 29, Issue:2

    Topics: Adenine; Animals; Indoles; Nerve Degeneration; Prion Diseases; Unfolded Protein Response

2014
Involvement of autophagy upregulation in 3,4-methylenedioxymethamphetamine ('ecstasy')-induced serotonergic neurotoxicity.
    Neurotoxicology, 2016, Volume: 52

    Topics: Adenine; Animals; Autophagy; Benzylamines; Brain Stem; Cells, Cultured; Citalopram; Dose-Response Re

2016
Autophagy is involved in the ischemic preconditioning.
    Neuroscience letters, 2009, Feb-13, Volume: 451, Issue:1

    Topics: Adenine; Animals; Autophagy; Cathepsin D; Cell Survival; HSP70 Heat-Shock Proteins; Hypoxia-Ischemia

2009
Serum deprivation induced autophagy and predominantly an AIF-dependent apoptosis in hippocampal HT22 neurons.
    Apoptosis : an international journal on programmed cell death, 2009, Volume: 14, Issue:11

    Topics: Adenine; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autopha

2009
A new ethyladenine antagonist of adenosine A(2A) receptors: behavioral and biochemical characterization as an antiparkinsonian drug.
    Neuropharmacology, 2010, Volume: 58, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adenine; Animals; Antiparkinson Agents; Autoradiograph

2010
Acute NMDA toxicity in cultured rat cerebellar granule neurons is accompanied by autophagy induction and late onset autophagic cell death phenotype.
    BMC neuroscience, 2010, Feb-18, Volume: 11

    Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Caspase 3; Cell Death; Cells,

2010
Acute axonal degeneration in vivo is attenuated by inhibition of autophagy in a calcium-dependent manner.
    Autophagy, 2010, Volume: 6, Issue:5

    Topics: Adenine; Animals; Autophagy; Axons; Calcium; Humans; MCF-7 Cells; Nerve Crush; Nerve Degeneration; O

2010
Neuroprotective and anti-inflammatory effects of the adenosine A(2A) receptor antagonist ST1535 in a MPTP mouse model of Parkinson's disease.
    Synapse (New York, N.Y.), 2011, Volume: 65, Issue:3

    Topics: Adenine; Adenosine A2 Receptor Antagonists; Animals; Anti-Inflammatory Agents; Brain; Immunohistoche

2011
Beclin 1 knockdown inhibits autophagic activation and prevents the secondary neurodegenerative damage in the ipsilateral thalamus following focal cerebral infarction.
    Autophagy, 2012, Volume: 8, Issue:1

    Topics: Adenine; Amyloid beta-Peptides; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin

2012
NINJURIN1 single nucleotide polymorphism and nerve damage in leprosy.
    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2012, Volume: 12, Issue:3

    Topics: Adenine; Adult; Aged; Alanine; Alleles; Asparagine; Case-Control Studies; Cell Adhesion Molecules, N

2012
L-carnitine suppresses the onset of neuromuscular degeneration and increases the life span of mice with familial amyotrophic lateral sclerosis.
    Brain research, 2006, Jan-27, Volume: 1070, Issue:1

    Topics: Adenine; Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Carnitine; Disease Progression; Female;

2006
Induction of autophagy in neurite degeneration of mouse superior cervical ganglion neurons.
    The European journal of neuroscience, 2007, Volume: 26, Issue:10

    Topics: Adenine; Amino Acid Chloromethyl Ketones; Animals; Apoptosis Regulatory Proteins; Autophagy; Autopha

2007
Degenerative changes of neurocytes in the light of autoradiographic investigations.
    Pathologia Europaea, 1971, Volume: 6, Issue:2

    Topics: Adenine; Amino Acids; Animals; Autoradiography; Brain; Carbon Isotopes; Cerebral Cortex; Disease Mod

1971